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PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy. 普瑞巴林和度洛西汀联合治疗糖尿病疼痛性多发性神经病变后的 PPARγ 和 AKt 基因调节作用
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-12 DOI: 10.1080/17581869.2024.2370758
Ashok K Saxena, Nimisha Thanikkal, Geetanjali T Chilkoti, Prakash G Gondode, Tusha Sharma, Basu D Banerjee
{"title":"<i>PPARγ</i> and <i>AKt</i> gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy.","authors":"Ashok K Saxena, Nimisha Thanikkal, Geetanjali T Chilkoti, Prakash G Gondode, Tusha Sharma, Basu D Banerjee","doi":"10.1080/17581869.2024.2370758","DOIUrl":"10.1080/17581869.2024.2370758","url":null,"abstract":"<p><p><b>Aim:</b> Diabetic peripheral neuropathy (DPN) induces chronic neuropathic pain in diabetic patients. Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine versus pregabalin alone for DPN pain relief, and explores gene modulation (<i>PPARγ</i> and <i>Akt</i>) to understand neuropathic pain's molecular basis.<b>Materials & methods:</b> Diabetic patients with DPN were randomized into groups receiving combination therapy or pregabalin alone for 4 weeks. Pain intensity, gene expression and quality of life were assessed.<b>Results:</b> Combination therapy significantly reduced pain, improved quality of life and upregulated <i>PPARγ</i> and <i>Akt</i> genes compared with monotherapy.<b>Conclusion:</b> Pregabalin and duloxetine combination therapy in DPN led to <i>PPARγ</i> mRNA upregulation and negative correlation of <i>Akt</i> gene expression with pain scores. This combination therapy effectively reduced pain and improved quality of life.<b>Clinical Trial Registration:</b> CTRI/2021/02/031068.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical refractory occipital neuralgia treated with a unilateral dual-lead occipital nerve stimulator: a case report. 用单侧双导联枕神经刺激器治疗非典型难治性枕神经痛：病例报告。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-29 DOI: 10.1080/17581869.2024.2376515
Daniel Wang, Crystal Li, Ali Turabi
{"title":"Atypical refractory occipital neuralgia treated with a unilateral dual-lead occipital nerve stimulator: a case report.","authors":"Daniel Wang, Crystal Li, Ali Turabi","doi":"10.1080/17581869.2024.2376515","DOIUrl":"10.1080/17581869.2024.2376515","url":null,"abstract":"<p><p><b>Aim:</b> To describe the successful treatment of atypical occipital neuralgia (ON) using a unilateral dual-lead occipital nerve stimulator.<b>Setting:</b> Outpatient clinic/operating room.<b>Patient:</b> A 53-year-old male with atypical ON.<b>Case description:</b> Patient was previously diagnosed with treatment-refractory left-sided trigeminal neuralgia with atypical occipital distribution. On presentation, his symptoms were consistent with ON with distribution to the left fronto-orbital area. He received a left-sided nerve stimulator implant targeting both the greater and lesser occipital nerves.<b>Results:</b> Patient reported pain relief from a numerical rating scale 10/10 to 3-4/10.<b>Conclusion:</b> ON with referred ipsilateral trigeminal distribution should be considered when patients present with simultaneous facial and occipital pain. Further, a dual-lead unilateral stimulator approach may be a viable treatment.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging innovation in pain medicines. 止痛药物的新兴创新。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-09 DOI: 10.1080/17581869.2024.2385285
Anita Gupta, Gerard Limerick, Jamie Hsu, Jennifer Javaheri, Artin Allahverdian, Paul J Christo
{"title":"Emerging innovation in pain medicines.","authors":"Anita Gupta, Gerard Limerick, Jamie Hsu, Jennifer Javaheri, Artin Allahverdian, Paul J Christo","doi":"10.1080/17581869.2024.2385285","DOIUrl":"10.1080/17581869.2024.2385285","url":null,"abstract":"<p><p>The treatment of pain remains a critical, unmet public health challenge. According to the CDC, in 2021, an estimated 20.9% of US adults (51.6 million people) endured chronic pain, and 6.9% (17.1 million people) endured high-impact chronic pain. Additionally, the impact of the social determinants of health on pain treatment are beginning to emerge. Treating pain addresses its control and relief, enhancing patient outcomes and quality of life. However, current treatment options have limitations, creating a significant need for innovative solutions. This raises the role of innovation in identifying new pain medicines. Thus, the clinical development of novel pain medicines is an unmet need to address public health worldwide.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of social determinants of health on chronic opioid therapy for chronic non-cancer pain. 健康的社会决定因素对慢性非癌性疼痛阿片类药物长期治疗的影响。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-06-21 DOI: 10.1080/17581869.2024.2366145
Minghui Chen, Tao Li
{"title":"Impacts of social determinants of health on chronic opioid therapy for chronic non-cancer pain.","authors":"Minghui Chen, Tao Li","doi":"10.1080/17581869.2024.2366145","DOIUrl":"10.1080/17581869.2024.2366145","url":null,"abstract":"<p><p><b>Aim:</b> We aimed to investigate the association between social determinants of health and chronic opioid therapy.<b>Materials & methods:</b> We conducted a retrospective analysis of electronic health records from five family medicine and internal medicine clinics in Oregon in 2020 and 2021. Our outcome variable was whether a patient was receiving chronic opioid therapy for chronic non-cancer pain. Our variables of interest included financial difficulty, insurance types, transportation barriers, currently married or living with a partner and organizations participation.<b>Results:</b> Our results showed that patients with financial difficulty were more likely to have chronic opioid therapy (OR: 2.69; 95% CI: 1.14, 6.33).<b>Conclusion:</b> Addressing patients' social determinants of health disadvantages is important for optimizing pain management.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suprascapular nerve peripheral nerve stimulation for pediatric cancer pain: a case series. 肩胛上神经周围神经刺激治疗小儿癌痛：病例系列。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-26 DOI: 10.1080/17581869.2024.2376523
Soun Sheen, Imad Riazuddin, Saba Javed
{"title":"Suprascapular nerve peripheral nerve stimulation for pediatric cancer pain: a case series.","authors":"Soun Sheen, Imad Riazuddin, Saba Javed","doi":"10.1080/17581869.2024.2376523","DOIUrl":"10.1080/17581869.2024.2376523","url":null,"abstract":"<p><p><b>Aim:</b> Despite the growing evidence supporting the use of peripheral nerve stimulation (PNS) for cancer pain in adults, it is underutilized in the pediatric oncology population.<b>Method:</b> We describe the use of temporary, percutaneous PNS for pain management in pediatric patients suffering from cancer related pain.<b>Results:</b> Two adolescent patients underwent an ultrasound-guided suprascapular nerve PNS placement utilizing the percutaneous 60-day therapy system. Both patients reported approximately 60% pain relief during the therapy, as well as up to 90 days post lead removal.<b>Conclusion:</b> PNS may play a crucial role in the pediatric oncology population. Further studies are warranted to investigate the efficacy and safety of PNS for various cancer-related pain conditions in pediatric populations.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional versus cooled-radiofrequency neurotomy for the treatment of chronic lumbar facet (zygapophyseal) joint pain. 治疗慢性腰椎面（颧骨）关节疼痛的传统方法与冷却射频神经切断术的比较。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-30 DOI: 10.1080/17581869.2024.2377061
Burcu Candan, Semih Gungor
{"title":"Traditional versus cooled-radiofrequency neurotomy for the treatment of chronic lumbar facet (zygapophyseal) joint pain.","authors":"Burcu Candan, Semih Gungor","doi":"10.1080/17581869.2024.2377061","DOIUrl":"10.1080/17581869.2024.2377061","url":null,"abstract":"<p><p><b>Aim:</b> Traditional radiofrequency ablation (TRFA) effectively treats facet joint-related pain, while water-cooled radiofrequency ablation (CRFA) may offer benefits like larger lesions and easier nerve access. Our goal is to assess the effectiveness of TRFA and CRFA for facet joint-related pain.<b>Materials & methods:</b> This retrospective study included an evaluation of 346 RFA interventions performed on 190 patients suffering from long-term low-back pain. The primary outcome was defined as a decrease of ≥50% of the mean numeric rating scale.<b>Results:</b> The primary outcome was achieved at the first follow-up (FU) for both TRFA and CRFA, with pain relief of 55.2 and 60.5%, respectively. At the second FU, the primary outcome was achieved only in the CRFA group (54.1%), although the TRFA group also showed a good improvement (48.6%). In both groups, pain relief was under 50% during the third FU.<b>Conclusion:</b> Our study indicates that both CRFA and TRFA modalities are effective and safe treatments.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141793048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical neurolysis for the conservative treatment of hip fractures. 化学神经溶解术用于髋部骨折的保守治疗。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-06-28 DOI: 10.1080/17581869.2024.2368453
Catarina C Duarte, João Galacho, Alexandra Resende, André Spranger, Mariano Veiga
{"title":"Chemical neurolysis for the conservative treatment of hip fractures.","authors":"Catarina C Duarte, João Galacho, Alexandra Resende, André Spranger, Mariano Veiga","doi":"10.1080/17581869.2024.2368453","DOIUrl":"10.1080/17581869.2024.2368453","url":null,"abstract":"<p><p><b>Aim:</b> Hip fracture management is challenging when surgical risks outweigh benefits. Inadequate analgesia from conservative treatments prompted new procedures targeting hip capsule denervation. This study evaluates the efficacy and safety of single injection chemical hip neurolysis in the pericapsular nerve group plane.<b>Materials & methods:</b> In eligible patients, an ultrasound-guided diagnostic block was performed using 5 ml of 2% lidocaine in the pericapsular nerve group plane. If positive, 6 ml of 99.9% alcohol was administered.<b>Results:</b> From May 2022 to May 2023, five patients underwent hip neurolysis. None reported pain at day 5 or during follow-up. There were no adverse effects.<b>Conclusion:</b> Chemical neurolysis seems to provide effective and safe conservative treatment for hip fractures, offering reliable analgesia for nonsurgical candidates.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding providers' perspectives using patient-reported outcomes in a pain management setting: a pilot study. 利用疼痛管理环境中的患者报告结果了解服务提供者的观点：一项试点研究。
IF 1.7
Pain management Pub Date : 2024-04-04 DOI: 10.2217/pmt-2023-0084
Lisa R. Witkin, Abha Kasubhai, Silis Y Jiang, Ruth Gotian
{"title":"Understanding providers' perspectives using patient-reported outcomes in a pain management setting: a pilot study.","authors":"Lisa R. Witkin, Abha Kasubhai, Silis Y Jiang, Ruth Gotian","doi":"10.2217/pmt-2023-0084","DOIUrl":"https://doi.org/10.2217/pmt-2023-0084","url":null,"abstract":"Aim: This pilot study evaluated an electronic patient-reported outcomes collection system in pain management to understand providers' experiences using the data, and how it affects their patient interaction and guides their clinical decision-making. Materials & methods: Using stratified convenience sampling, nine semi-structured interviews were conducted with consented pain physicians. The transcribed, de-identified interviews were coded and analyzed. Results: Although most physicians utilized patient reported outcomes (PROs), one-third reported no significant change in their practice since implementation and 56% stated it does not influence their treatment recommendations. Conclusion: Despite the importance of measuring the impact of chronic pain on quality of life, there are significant limitations to the real-world use of PRO that may limit the patient's assessment and care.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Techniques in medicine: ipsilateral transforaminal epidural steroid injection in Bertolotti's syndrome. 医学技术：同侧经穿孔硬膜外注射类固醇治疗贝尔托洛蒂综合征。
IF 1.7
Pain management Pub Date : 2024-03-01 Epub Date: 2024-02-22 DOI: 10.2217/pmt-2023-0105
Peter D Vu, Christopher L Robinson, Omar Viswanath, Ivan Urits, Jamal Hasoon
{"title":"Techniques in medicine: ipsilateral transforaminal epidural steroid injection in Bertolotti's syndrome.","authors":"Peter D Vu, Christopher L Robinson, Omar Viswanath, Ivan Urits, Jamal Hasoon","doi":"10.2217/pmt-2023-0105","DOIUrl":"10.2217/pmt-2023-0105","url":null,"abstract":"<p><p>Bertolotti's syndrome, also known as lumbosacral transitional vertebrae, is a relatively rare spinal condition characterized by an anatomical variation in the lower spine. Conservative approaches such as physical therapy, anti-inflammatory medications and lifestyle modifications may be recommended for mild cases. In more severe cases or when conservative measures fail to provide relief, injections such as may be considered to alleviate pain. This case is unique in that we document a challenging technique of ipsilateral transforaminal epidural steroid injection in a patient with Bertolotti's syndrome.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pain as a disease in the new International Classification of Diseases (ICD-11): Latin American expert consensus. 在新的《国际疾病分类》（ICD-11）中，疼痛是一种疾病：拉丁美洲专家共识。
IF 1.7
Pain management Pub Date : 2024-03-01 Epub Date: 2024-02-21 DOI: 10.2217/pmt-2023-0096
Marco A Narvaez Tamayo, Carlos Aguayo, Elias Atencio, Joao Batista Garcia, Carmen Cabrera, Celina Castañeda, Pablo Castroman, Graciela Elizeche, Patricia Gomez, Santiago Guaycochea, Marixa Guerrero, Rocio Guillen, Carla Leal Pereira, Guillermo López, Jacqueline Macias, Bethania Martinez, Felipe Mejia, Enrique Orrillo, José O Oliveira, Fabian Piedimonte, Francisco Samayoa, Martin Toro
{"title":"Pain as a disease in the new International Classification of Diseases (ICD-11): Latin American expert consensus.","authors":"Marco A Narvaez Tamayo, Carlos Aguayo, Elias Atencio, Joao Batista Garcia, Carmen Cabrera, Celina Castañeda, Pablo Castroman, Graciela Elizeche, Patricia Gomez, Santiago Guaycochea, Marixa Guerrero, Rocio Guillen, Carla Leal Pereira, Guillermo López, Jacqueline Macias, Bethania Martinez, Felipe Mejia, Enrique Orrillo, José O Oliveira, Fabian Piedimonte, Francisco Samayoa, Martin Toro","doi":"10.2217/pmt-2023-0096","DOIUrl":"10.2217/pmt-2023-0096","url":null,"abstract":"<p><p><b>Aims:</b> Pain diagnoses in the 10th version of the International Classification of Diseases (ICD-10) did not adequately support the current management of pain. Therefore, we aimed to review the new 11th revision (ICD-11) in order to analyze its usefulness for the management, coding, research and education of chronic pain from a Latin American perspective. <b>Methods:</b> The Latin American Federation of Associations for the Study of Pain convened a meeting of pain experts in Lima, Peru. Pain specialists from 14 Latin American countries attended the consensus meeting. <b>Results:</b> In ICD-11, chronic pain is defined as pain that persists or recurs longer than 3 months and is subdivided into seven categories: chronic primary pain and six types of chronic secondary pain. Chronic primary pain is now considered a disease in itself, and not a mere symptom of an underlying disease. <b>Conclusion:</b> The novel definition and classification of chronic pain in ICD-11 is helpful for better medical care, research and health statistics. ICD-11 will improve chronic pain management in Latin American countries, for both the pain specialist and the primary care physician.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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