Pain management最新文献

{"title":"STIMFIX™ anchoring in percutaneous spinal cord stimulation trials: interim analysis of a multicenter study.","authors":"Maja Green, Lakshmi Narra, Saurabh Dang, Jack Diep, Dipan Patel, Philip Lim, Joseph Atallah, Krishnan Chakravarthy","doi":"10.1080/17581869.2025.2527576","DOIUrl":"https://doi.org/10.1080/17581869.2025.2527576","url":null,"abstract":"<p><strong>Aims: </strong>Lead migration during percutaneous spinal cord stimulation (SCS) trials can undermine therapeutic efficacy. This study evaluates the effectiveness of the novel, noninvasive STIMFIX anchoring system in reducing lead migration compared to conventional anchoring techniques.</p><p><strong>Patients & methods: </strong>This interim analysis included two prospectively collected cohorts. Group 1 (<i>n</i> = 28) was a randomized, single-center trial comparing three anchoring methods: sutures (<i>n</i> = 9), adhesive tape (<i>n</i> = 10), and manufacturer-provided anchors (<i>n</i> = 9). Group 2 (<i>n</i> = 20) was a multicenter, open-label, non-randomized study using STIMFIX anchors. Lead migration was measured via standardized fluoroscopic imaging on Days 1 and 7.</p><p><strong>Results: </strong>Mean lead migration in Group 1 was 33.5 mm (manufacturer anchor), 29.4 mm (tape), and 21.1 mm (sutures), with no significant differences between groups (<i>p</i> = 0.404). Group 2 demonstrated an average lead migration of 19.5 mm with STIMFIX. No major adverse events were reported; one case of minor skin irritation resolved without intervention.</p><p><strong>Conclusions: </strong>STIMFIX demonstrated reduced lead migration compared to conventional methods, with favorable safety and ease of application. These findings support its use as a promising advancement in SCS trial anchoring.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT05651646.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-13"},"PeriodicalIF":1.4,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating patient satisfaction and perceived accuracy in questionnaires completed before vs. during a pain clinic visit.","authors":"Guy Feigin, Elad Dana, Victoria Bains, Anuj Bhatia","doi":"10.1080/17581869.2025.2529773","DOIUrl":"https://doi.org/10.1080/17581869.2025.2529773","url":null,"abstract":"<p><strong>Introduction: </strong>Effective assessment is essential for planning treatment in chronic pain management. This study compared patient satisfaction and perceived data accuracy between completing pre-assessment questionnaires at home versus in the clinic prior to a neuromodulation consultation.</p><p><strong>Methods: </strong>In this prospective, single-center study, adult patients referred for neuromodulation assessment were randomized to complete intake questionnaires either at home (\"Home\" group) or upon arrival at the clinic (\"Clinic\" group). Prior the appointment, all participants completed a satisfaction survey assessing perceived accuracy, time efficiency, and preference.</p><p><strong>Results: </strong>Forty-two patients participated (Home: 17; Clinic: 25). Overall satisfaction was not significantly different between groups (88.2% vs. 64%, <i>p</i> = 0.202). However, perceived response accuracy (88.2% vs. 36%, <i>p</i> < 0.001) and time efficiency (82.4% vs. 28%, <i>p</i> = 0.002) were significantly higher in the Home group. More than half of Clinic group participants stated they would have preferred to complete the questionnaires at home (52% vs. 5.9%, <i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>Completing pre-assessment questionnaires at home resulted in higher perceived accuracy and time efficiency without compromising satisfaction. These findings support incorporating remote pre-visit assessments into chronic pain clinic workflows to optimize patient experience.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT03852381.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided neuromodulation for neuropathic pain after radial forearm flap reconstruction: a case report.","authors":"Tomás Caroço, Bruno Paiva, Jorge Ribeiro, Daniela Teixeira, Ivone Rodrigues, Gisela Henriques Leandro","doi":"10.1080/17581869.2025.2530379","DOIUrl":"https://doi.org/10.1080/17581869.2025.2530379","url":null,"abstract":"<p><p>Neuropathic pain is a common complication following radial forearm free flap (RFFF) reconstruction, often associated with damage to the superficial branch of the radial nerve (SBRN) and lateral antebrachial cutaneous nerve (LACN). Traditional treatment approaches, including pharmacologic and non-pharmacologic interventions, frequently provide incomplete pain relief. This case report describes the innovative use of ultrasound-guided musculocutaneous and SBRN blocks combined with pulsed radiofrequency (PRF) neuromodulation in a 70-year-old male with severe neuropathic pain following RFFF for tongue carcinoma reconstruction. The intervention provided immediate and complete pain relief, maintained for three days post-procedure. Partial symptom improvement persisted beyond the initial phase. Although complete pain relief was not sustained over the longer term, the significant initial response confirmed the targeted nerves as viable candidates for neuromodulation. This confirmation opens potential pathways for exploring longer-lasting neuromodulation techniques, such as cryoneurolysis or peripheral nerve stimulation, to achieve sustained pain relief. Further research into these modalities is recommended to optimize long-term outcomes for patients experiencing neuropathic pain post-RFFF reconstruction.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Citrus Aurantium L. on pain and blood pressure in patients undergoing hand reconstructive surgery.","authors":"Farideh Askari, Farzaneh Ghaffari, Nasrin Alaee, Mohsen Naseri, Akram Tayanloo-Beik","doi":"10.1080/17581869.2025.2515814","DOIUrl":"https://doi.org/10.1080/17581869.2025.2515814","url":null,"abstract":"<p><strong>Background and purpose: </strong>Postoperative pain and blood pressure are common patient complaints. This study examined the effects of Citrus Aurantium (CA) on pain and blood pressure in patients undergoing hand reconstructive surgery.</p><p><strong>Methods: </strong>A double-blind, randomized clinical trial was conducted with 76 patients. The control group received a placebo, while the intervention group received CA essential oil. Blood pressure and pain levels were recorded before the intervention, and at 30 minutes and one-hour post-surgery. Data collection used blood pressure sheets, numerical visual pain scales, and demographic questionnaires.</p><p><strong>Result: </strong>The intervention group showed significantly greater pain reduction than the control group (<i>p</i> = 0.001), with CA increasing the likelihood of pain reduction by 1.73 times (Exp(B) = 1.73). Systolic and diastolic blood pressure significantly decreased post-intervention (<i>p</i> = 0.001, <i>p</i> = 0.005), but differences were not significant after 30 minutes and one hour after (<i>p</i> > 0.05). CA increased the likelihood of systolic blood pressure reduction by 16.87 times (Exp(B) = 16.78), with no effect on diastolic pressure.</p><p><strong>Conclusion: </strong>CA facilitates pain and blood pressure reduction in aromatherapy, suggesting its use as a simple, inexpensive, and noninvasive method for postoperative pain management.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of epidural rescue in combined spinal-epidural anesthesia for cesarean delivery.","authors":"Kaissar Sassi, Juliette Linval, Etienne Bechet, Nancy El Achkar, Elsa Tardif, Vincent Minville","doi":"10.1080/17581869.2025.2526318","DOIUrl":"https://doi.org/10.1080/17581869.2025.2526318","url":null,"abstract":"<p><strong>Background: </strong>Combined spinal-epidural (CSE) is often recommended for cesarean deliveries expected to have prolonged duration. This study aimed to identify factors associated with the need for epidural rescue anesthesia during CSE for cesarean section, to better refine clinical indications for this technique.</p><p><strong>Methodology: </strong>This retrospective cohort study was conducted from 2020 to 2022 at the maternity of Toulouse University Hospital, France. Data were collected from 230 patients who underwent CSE for cesarean delivery. The mean age was 34.3 ± 5.6 years, 69.1% had previous cesarean sections, and 70% had a BMI > 24.9. Univariate analysis identified potential predictors, which were then included in multivariate logistic regression to determine independent factors associated with epidural rescue.</p><p><strong>Results: </strong>The overall rate of rescue epidural anesthesia was 16.5% (38/230). Multivariate analysis identified three independent predictors: gestational diabetes (adjusted odds ratio [aOR] 2.39, 95% CI: 1.07-5.29, <i>p</i> = 0.032), postpartum hemorrhage ≥ 500 mL (aOR 2.29, 95% CI: 1.35-3.90, <i>p</i> = 0.002), and surgical duration ≥ 62 minutes (aOR 4.36, 95% CI: 1.99-9.58, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Gestational diabetes, postpartum hemorrhage, and surgical duration exceeding 62 minutes significantly increase the likelihood of epidural rescue during CSE for cesarean delivery. These findings could guide more selective CSE use, potentially avoiding unnecessary epidural catheter placement in low-risk situations.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial.","authors":"Zahra Nejati, Babak Ghadirzadeh, Hady Mohammadi, Maryam Afraie, Yousef Moradi","doi":"10.1080/17581869.2025.2528590","DOIUrl":"https://doi.org/10.1080/17581869.2025.2528590","url":null,"abstract":"<p><strong>Aim: </strong>This study primarily aimed to evaluate the efficacy of Coenzyme Q10 supplementation in improving post-extraction tissue healing and, secondarily, its effects on reducing temporomandibular disorders (TMD), dry socket and enhancing quality of life following wisdom tooth extraction.</p><p><strong>Patients and methods: </strong>This parallel randomized, double-blind, placebo-controlled trial included 70 participants, randomly assigned to receive either CoQ10 or placebo. The primary outcome was tissue healing, measured by clinical assessments on days 7, 14 and 30 post-surgeries; alongside secondary outcomes including the occurrence of TMD and dry socket occurrence. Additional secondary outcomes included physical and psychological recovery, assessed using the 36-item short form survey (SF36) and the 12-item general health questionnaire (GHQ12), which measure psychological distress and health-related quality of life.</p><p><strong>Results: </strong>On day 7, the CoQ10 group showed a significant 45% improvement in tissue healing, compared to its counterpart and by day 14, showed a 55% improvement. TMD occurred in 12% of the CoQ10 group vs. 30% in the placebo group; and dry socket was 6% in the CoQ10 group vs. 18% in the placebo group.</p><p><strong>Conclusion: </strong>Coenzyme Q10 supplementation significantly accelerates tissue healing, reduces TMD and dry socket incidence and improves physical and mental health outcomes following wisdom tooth extraction.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov [registration number NCT06452134].</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative cryoneurolysis for peri- and postoperative pain in total knee arthroplasty: a systematic review and pooled analysis.","authors":"Brandon Goodwin, Hanna Brancaccio, Mitchell Kaplan, Valerie Rome, Sameer Shah, Sweta Mukhopadhyay, Seungkyu Park, Gilbert Siu","doi":"10.1080/17581869.2025.2522063","DOIUrl":"https://doi.org/10.1080/17581869.2025.2522063","url":null,"abstract":"<p><strong>Background: </strong>Cryoneurolysis is seeing increased implementation in total knee arthroplasty (TKA), providing postoperative analgesia through preoperative cryoneurolysis of peripheral nerves. Thus, we are conducting this systematic review and meta-analysis to determine cryoneurolysis' efficacy in providing analgesia and improvements in recovery times for patients undergoing TKA.</p><p><strong>Methods: </strong>We conducted a comprehensive search using five databases including PubMed, Cochrane Library, Web of Science, Embase, and Scopus. The screened articles were assessed for inclusion of primary outcomes: pain scores before nerve cryoablation, peri- and post-operative pain scores in TKA, length of pain relief, patient demographics, and type of pain score employed. The Higgins I² test served to discern the degree of heterogeneity between included studies. Cohen's d was utilized to interpret the pooled effect size of the studies.</p><p><strong>Results: </strong>Our search yielded six articles that met our inclusion criteria. The overall effect size illustrated a d = 1.468 (95% CI: 1.084-1.851; <i>p</i> < 0.001) for the Visual Analog Score (VAS), Numerical Rating Score (NRS), and Patient-Reported Outcomes Measurement Information System (PROMIS) pain subscore. Each individual study possessed a large effect size.</p><p><strong>Conclusion: </strong>Our comprehensive review and meta-analysis indicated that cryoneurolysis provides effective pain management, providing TKA patients with significant pain reduction for 6-12 weeks post-surgery. Furthermore, improvements were observed in patient-centered outcomes: mobility, return to routine activities, and overall satisfaction. Future studies should be conducted to determine the long-term efficacy of cryoneurolysis and the appropriate timing and duration of cryoneurolysis to maximize its analgesic abilities.</p><p><strong>Protocolregistration: </strong>www.crd.york.ac.uk/prospero identifier is CRD42024542005.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-enhanced pain management: the NXTSTIM EcoAI platform.","authors":"Maja Green, Krishnan Chakravarthy","doi":"10.1080/17581869.2025.2527575","DOIUrl":"https://doi.org/10.1080/17581869.2025.2527575","url":null,"abstract":"<p><p>Chronic pain affects approximately 20% of the global population, leading to significant disability and economic burden. Traditional management strategies, including pharmacologic interventions and physical therapies, often provide limited relief and are associated with adverse effects. Non-invasive neuromodulation techniques, such as transcutaneous electrical nerve stimulation (TENS) and electrical muscle stimulation (EMS), have shown promise but are hindered by issues like inconsistent dosing and poor adherence. The integration of artificial intelligence (AI) into pain management offers a novel approach to personalize and optimize therapy. The NXTSTIM EcoAI platform exemplifies this innovation by combining TENS and EMS with machine learning (ML) algorithms, cloud-based analytics, and remote patient monitoring (RPM). This closed-loop system dynamically adjusts stimulation parameters based on real-time patient data, enhancing efficacy and user engagement. By continuously learning from individual responses and aggregated trends, EcoAI aims to provide tailored pain relief while addressing the limitations of conventional neuromodulation devices. This review explores the current landscape of pain management, the mechanisms of electrostimulation analgesia, and the potential of AI-driven digital therapeutics like EcoAI to revolutionize chronic pain treatment.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repurposed versus disease-specific medicinals for the prophylaxis of migraine: an updated systematic review.","authors":"Savvas-Ilias Christofilos, Theodoros Mavridis, Viktor Gkotzamanis, Sofia Vasilopoulou, Christina I Deligianni, Mitsikostas Dimos-Dimitrios","doi":"10.1080/17581869.2025.2509474","DOIUrl":"10.1080/17581869.2025.2509474","url":null,"abstract":"<p><strong>Background: </strong>Gepants, selective antagonists of the calcitonin gene-related peptide (CGRP) receptor, and monoclonal antibodies targeting CGRP or its receptor (anti-CGRP mAbs) are promising migraine treatments, demonstrating superior tolerability than traditional preventives. While their efficacy over placebo is established, their comparative benefit-risk profiles remain to be fully elucidated.</p><p><strong>Objective: </strong>To indirectly compare the benefit-risk ratios of gepants with anti-CGRP mAbs and repurposed preventives.</p><p><strong>Methods: </strong>A comprehensive search of PubMed/MEDLINE and ClinicalTrials.gov was conducted to identify phase-3, placebo-controlled trials of gepants (atogepant, rimegepant), anti-CGRP mAbs (eptinezumab, erenumab, fremanezumab, galcanezumab), and traditional treatments (propranolol, topiramate, onabotulinumtoxinA). The number needed to treat (NNT) for achieving ≥50% reduction in migraine days and the number needed to harm (NNH) for adverse effects were calculated to determine the likelihood to help versus harm (LHH) values.</p><p><strong>Results: </strong>Twenty-seven studies were included: 15 of mAbs, 4 of gepants, 2 of onabotulinumtoxin A, and 6 of standard treatments. Atogepant and fremanezumab exhibited the highest LHH in episodic migraine, and galcanezumab and eptinezumab performed favorably in chronic migraine concerning treatment discontinuation and treatment-related adverse effects.</p><p><strong>Conclusions: </strong>Anti-CGRP/R medications present a more favorable benefit/risk ratio than traditional treatments. These findings, combined with individual patient histories and preferences, can inform clinical decision-making.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"425-439"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of diamagnetic therapy to manage a patient with degenerative cervical myelopathy and drug's intolerance.","authors":"Vincenzo Rania, Gianmarco Marcianò, Cristina Vocca, Caterina Palleria, Lucia Muraca, Pietro Romeo, Felipe Torres, Luca Gallelli","doi":"10.1080/17581869.2025.2523729","DOIUrl":"10.1080/17581869.2025.2523729","url":null,"abstract":"<p><p>Degenerative cervical myelopathy (DCM) is a common condition with a prevalence of 24.2% in the healthy population, and 35.3% in patients older than 60 years. The management of this clinical condition is difficult and implies chronic management of patients. The risk of drug abuse is very high and may lead to important long-term consequences. Finding a therapeutic option capable to reduce the number of prescribed drugs and with few side effects is very important in DCM. We report a 44-year-old Caucasian woman who was diagnosed with DCM. Her medical history revealed that despite using multiple medications, she did not show any signs of improvement. She declined the surgical treatment as well. Following clinical assessment, a diamagnetic pump treatment with pulsed electromagnetic fields for 3 months (once-twice weekly for 30 min, magnetic flux density 86 mt at the site of treatment) resulted in a clinical improvement. The benefits of diamagnetic therapy were three-faced including pain improvement, functional status, and imaging (magnetic resonance imaging (MRI) showing bone marrow edema reduction and myelopathy improvement). This is the first case report in our knowledge to prove the effectiveness of diamagnetic therapy in DCM, alongside imaging and functional improvement.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"373-378"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}