Pain management最新文献_第6页

Efficacy and safety of mAbs anti-CGRP/CGRP R (eptinezumab and erenumab) or atogepant in combination with onabotulinumtoxinA in refractory chronic migraine: a clinical trial protocol. 单克隆抗体抗CGRP/CGRP R （eptinezumab和erenumab）或联合onabotulintoxina治疗难治性慢性偏头痛的疗效和安全性：一项临床试验方案

IF 1.4

Pain management Pub Date : 2025-04-01 DOI: 10.1080/17581869.2025.2487413

Damiana Scuteri, Gary W Lawrence, Rosario Iannacchero, Michele Trimboli, Pierluigi Nicotera, Maria T Corasaniti, Giacinto Bagetta

{"title":"Efficacy and safety of mAbs anti-CGRP/CGRP R (eptinezumab and erenumab) or atogepant in combination with onabotulinumtoxinA in refractory chronic migraine: a clinical trial protocol.","authors":"Damiana Scuteri, Gary W Lawrence, Rosario Iannacchero, Michele Trimboli, Pierluigi Nicotera, Maria T Corasaniti, Giacinto Bagetta","doi":"10.1080/17581869.2025.2487413","DOIUrl":"10.1080/17581869.2025.2487413","url":null,"abstract":"Chronic migraine is a disabling neurovascular disorder that represents the leading cause of years lived with disability in people under 50 with a remarkable social burden due to widespread resistance to the front-line treatments used routinely in current clinical practice. The present study investigates the efficacy and safety of combination therapy using eptinezumab and erenumab, recently approved monoclonal antibodies (mAbs) directed against calcitonin gene-related peptide or its receptor, respectively, or the receptor competitive antagonist atogepant together with botulinum toxin type A in chronic migraine that has proven resistant to front-line treatments for at least 6 weeks. To this aim a retrospective and a prospective phase are designed. Furthermore, a feasible salivary biomarker of migraine is under investigation in the prospective stage of the study. Based on recent expert opinions supporting the switch to easy-to-use small molecule calcitonin gene-related peptide (CGRP)-targeting, i.e. rimegepant or atogepant in unresponsive patients, the present study may offer to clinicians a novel treatment to enhance the therapeutic preventive machinery in chronic migraine.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"177-181"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Methadone in the madness: a case series and review of methadone management in hospital settings. 美沙酮在疯狂：一个案例系列和回顾美沙酮管理在医院设置。

IF 1.4

Pain management Pub Date : 2025-04-01 Epub Date: 2025-03-31 DOI: 10.1080/17581869.2025.2479411

Cormac F Mullins, Sarah Walsh, Joseph Fitzgerald

引用次数: 0

Altius electrical nerve stimulation for post-amputation pain treatment: a comprehensive review. 高肌电刺激治疗截肢后疼痛的综述。

IF 1.4

Pain management Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1080/17581869.2025.2473873

Syed I Khalid, Nikhil Veludandi, Chibueze Agwu, Konstantin V Slavin

{"title":"Altius electrical nerve stimulation for post-amputation pain treatment: a comprehensive review.","authors":"Syed I Khalid, Nikhil Veludandi, Chibueze Agwu, Konstantin V Slavin","doi":"10.1080/17581869.2025.2473873","DOIUrl":"10.1080/17581869.2025.2473873","url":null,"abstract":"Post-amputation pain (PAP), which includes both residual limb and phantom limb pain, affects up to 85% of amputees and severely impairs quality of life, mobility, and psychological well-being while incurring substantial healthcare costs. Conventional treatments - pharmacotherapy and neuromodulation techniques such as spinal cord stimulation and peripheral nerve stimulation - often provide inadequate relief and are associated with adverse effects like opioid dependence and systemic toxicity. The Altius High-Frequency Nerve Block System is an innovative therapeutic approach that delivers high-frequency alternating current (HFAC) directly to peripheral nerves, inducing a reversible conduction block without paresthesia. Clinical validation through the pivotal QUEST study - a multicenter, double-blind, randomized, active-sham controlled trial - has shown significant reductions in pain intensity and decreased reliance on pain medications in patients with chronic PAP. This review examines the physiological mechanisms of HFAC nerve block, outlines the development and clinical application of the Altius system, and evaluates its safety profile and broader implications for pain management. The findings suggest that the Altius system addresses a critical gap in PAP treatment, offering sustained pain relief, reduced opioid dependency, and improved quality of life for amputees.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"183-189"},"PeriodicalIF":1.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 1.4

Pain management Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.1080/17581869.2025.2477908

引用次数: 0

Peripheral nerve stimulation: recent advances and future directions. 外周神经刺激：最新进展及未来方向。

IF 1.4

Pain management Pub Date : 2025-04-01 Epub Date: 2025-04-09 DOI: 10.1080/17581869.2025.2488244

Suma Ganji-Angirekula, Saba Javed

引用次数: 0

Informal caregivers' burden and chronic pain in older adults: a dyadic study unveiling the correlation and its impact. 非正式照顾者的负担和老年人慢性疼痛：揭示相关性及其影响的二元研究。

IF 1.4

Pain management Pub Date : 2025-03-01 Epub Date: 2025-02-19 DOI: 10.1080/17581869.2025.2467614

Mimi Mun Yee Tse, Shamay Sheung Mei Ng, Vivian Lou, Raymond S K Lo, Daphne Sze Ki Cheung, Paul H Lee, Angel Shuk Kwan Tang, Kin Pong To, Percy Poo-See Tse

{"title":"Informal caregivers' burden and chronic pain in older adults: a dyadic study unveiling the correlation and its impact.","authors":"Mimi Mun Yee Tse, Shamay Sheung Mei Ng, Vivian Lou, Raymond S K Lo, Daphne Sze Ki Cheung, Paul H Lee, Angel Shuk Kwan Tang, Kin Pong To, Percy Poo-See Tse","doi":"10.1080/17581869.2025.2467614","DOIUrl":"10.1080/17581869.2025.2467614","url":null,"abstract":"Background and aims: Older adults' chronic pain care includes assisting with daily activities and exercise. But the informal caregivers have stated different challenges in the caring process. This study aims to explore the chronic pain situations of older adults, the burden of their informal caregivers, and the correlation between the severity of chronic pain in older adults and the level of burden experienced by their caregivers.Methods: A total of 150 older adults (mean age: 65.44) with chronic pain and 150 informal caregivers (mean age: 41.06) were recruited for this study. Older adults completed the brief pain inventory and pain self-efficacy questionnaire. Depression, anxiety, stress, and activities of daily living were assessed. Informal caregivers also completed the caregiver burden inventory.Results: 150 informal caregivers completed the questionnaire. The mean caregiver burden score was 3.73, positively associated with pain conditions and emotional tolls in older adults.Conclusion: The findings highlight the need for healthcare professionals to address the physical and emotional burdens experienced by informal caregivers. Healthcare professionals should investigate the caregiver burden. Comprehensive support strategies should be developed to enhance the well-being of both older adults and their caregivers, ultimately improving pain management and quality of life.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"123-130"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overlooked cause of upper extremity pain: myofascial trigger points of the triceps muscle and dry needling protocol. 上肢疼痛的一个被忽视的原因：肌筋膜触发点的三头肌和干针刺方案。

IF 1.4

Pain management Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1080/17581869.2025.2464526

Aylin Ayyıldız, Burak Tayyip Dede, Mustafa Hüseyin Temel, Bülent Alyanak, Mustafa Turgut Yıldızgören, Fatih Bağcıer

引用次数: 0

A unique utilization of scrambler therapy for bilateral neuropathic corneal pain: a case report. 扰频器治疗双侧神经性角膜疼痛的独特应用：一例报告。

IF 1.4

Pain management Pub Date : 2025-03-01 Epub Date: 2025-02-23 DOI: 10.1080/17581869.2025.2470612

Peter D Vu, Salahadin Abdi

引用次数: 0

Effectiveness and safety of anti-CGRP monoclonal antibodies for migraine in patients over 65 years: a systematic review. 抗cgrp单克隆抗体治疗65岁以上偏头痛患者的有效性和安全性：一项系统综述

IF 1.4

Pain management Pub Date : 2025-03-01 Epub Date: 2025-03-03 DOI: 10.1080/17581869.2025.2470615

Albert Muñoz-Vendrell, Alba López-Bravo, Almudena Layos-Romero, Francisco J Alberola-Amores, María Obdulia Lozano Caballero, Antonio Sánchez-Soblechero, Cristian Morales-Hernández, María Victoria Castro-Sánchez, María Pilar Navarro-López, María Rocío Córdova-Infantes, Edoardo Caronna, Pablo Irimia, Alicia Gonzalez-Martinez

{"title":"Effectiveness and safety of anti-CGRP monoclonal antibodies for migraine in patients over 65 years: a systematic review.","authors":"Albert Muñoz-Vendrell, Alba López-Bravo, Almudena Layos-Romero, Francisco J Alberola-Amores, María Obdulia Lozano Caballero, Antonio Sánchez-Soblechero, Cristian Morales-Hernández, María Victoria Castro-Sánchez, María Pilar Navarro-López, María Rocío Córdova-Infantes, Edoardo Caronna, Pablo Irimia, Alicia Gonzalez-Martinez","doi":"10.1080/17581869.2025.2470615","DOIUrl":"10.1080/17581869.2025.2470615","url":null,"abstract":"Background: Migraine patients over 65 years have been excluded from pivotal anti-CGRP monoclonal antibody trials leaving limited real-life data on effectiveness and safety in this population. This review aims to summarize available evidence on treatment response and safety for older patients.Methods: A PubMed and Cochrane Controlled Register of Trials (CENTRAL) search identified studies on anti-CGRP monoclonal antibodies in patients with migraine over 65 up to October 2024. The review focuses on headache outcomes like reduction in monthly migraine days or monthly headache days, response rates (30%, 50%, 75%) and adverse effects of this specific population and/or against placebo, standard care, or younger patients. The quality of evidence was assessed using the GRADE tool.Results: All eligible studies were included, along with additional articles presented narratively. Data from clinical trials and post-hoc analyses show comparable efficacy and safety between older and younger patients. Similarly, early real-life studies support the use of anti-CGRP monoclonal antibodies in patients over 65 years, showing similar response rates, reductions in monthly migraine days and adverse effects.Discussion: Anti-CGRP monoclonal antibodies should likely be offered to patients over 65 although available evidence remains limited. Further studies analyzing specific data from this subgroup are necessary.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":"15 3","pages":"161-171"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11916378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low health literacy impact on headache diagnosis. 低健康素养对头痛诊断的影响。

IF 1.4

Pain management Pub Date : 2025-03-01 Epub Date: 2025-02-22 DOI: 10.1080/17581869.2025.2463874

Joseph V Pergolizzi, Jo Ann LeQuang

{"title":"Low health literacy impact on headache diagnosis.","authors":"Joseph V Pergolizzi, Jo Ann LeQuang","doi":"10.1080/17581869.2025.2463874","DOIUrl":"10.1080/17581869.2025.2463874","url":null,"abstract":"Health literacy has a broad range of impacts, including whether and where a person seeks treatment and how well that patient interprets and applies clinical recommendations. Patients with headache may not seek treatment, may fail to disclose even severe pain to their physician, and may not understand or adhere to treatment. Universal precautions can be a helpful initial approach, and information styles can be modified as needed over time. Patients should be asked about headache and explanations about headache causes and treatment should be given in everyday language. The teach-back method can confirm if patients understand instructions. Health literacy can impact how patients perceive their headaches and how well they adhere to treatments. Health literacy is a two-way street; it depends on the patient's ability to understand and act on clinical information and the clinician's ability to give clear information. Language and cultural barriers can adversely impact health literacy, even in patients who otherwise have good understanding of medical advice. While health literacy can impact outcomes, those with low or very high health literacy are most likely to be non-adherent, albeit for different reasons. Clinical action plans can be valuable for those with severe headache.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"141-147"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0