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VX-548 in the treatment of acute pain. VX-548 用于治疗急性疼痛。
IF 1.4
Pain management Pub Date : 2024-09-01 Epub Date: 2024-11-18 DOI: 10.1080/17581869.2024.2421749
Aaron Yik Hang Kong, Hon Sen Tan, Ashraf S Habib
{"title":"VX-548 in the treatment of acute pain.","authors":"Aaron Yik Hang Kong, Hon Sen Tan, Ashraf S Habib","doi":"10.1080/17581869.2024.2421749","DOIUrl":"10.1080/17581869.2024.2421749","url":null,"abstract":"<p><p>Acute pain management requires balancing analgesia with adverse effects risk. The voltage-gated sodium channel NaV1.8 plays an important role in pain physiology, and its inhibition was shown to have analgesic effects. VX-548 is a new oral NaV1.8-specific inhibitor that received United States Food and Drug Administration Fast Track and Breakthrough Therapy designations. Its efficacy was demonstrated in two Phase II trials of patients who underwent abdominoplasty and bunionectomy. These showed that VX-548, when given as an oral loading dose of 100 mg followed by 50 mg 12-hly, significantly decreased pain scores compared with placebo. Similarly, two Phase III trials of patients who underwent abdominoplasty and bunionectomy comparing VX-548 with hydrocodone bitartrate-acetaminophen and placebo reported significantly reduced pain scores compared with placebo, but no improvement compared with hydrocodone bitartrate-acetaminophen. Evidence from Phase II and III trials suggest that VX-548 is well-tolerated, with headache, nausea, constipation and dizziness being the most common adverse effects. However, the safety of prolonged VX-548 administration is uncertain; a Phase II trial of patients with diabetic neuropathy who received high-dose VX-548 over 12 weeks reported decreased creatinine clearance. Data pertaining to VX-548 safety and efficacy within the context of multimodal analgesia and pregnancy are also needed.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"477-486"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Trying to explain the unexplainable": why research on contextual factors in musculoskeletal pain is needed. "试图解释无法解释的问题"：为什么需要对肌肉骨骼疼痛的环境因素进行研究？
IF 1.4
Pain management Pub Date : 2024-09-01 Epub Date: 2024-09-27 DOI: 10.1080/17581869.2024.2406224
Giacomo Rossettini, Alvisa Palese, Chad Cook
{"title":"\"Trying to explain the unexplainable\": why research on contextual factors in musculoskeletal pain is needed.","authors":"Giacomo Rossettini, Alvisa Palese, Chad Cook","doi":"10.1080/17581869.2024.2406224","DOIUrl":"10.1080/17581869.2024.2406224","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"465-468"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polmacoxib 2mg in patients with mild to moderate idiopathic osteoarthritis of hip/knee-a randomized, double-anonymous study. 针对轻度至中度特发性髋关节/膝关节骨关节炎患者的 2 毫克波马昔布--一项随机、双匿名研究。
IF 1.4
Pain management Pub Date : 2024-09-01 Epub Date: 2024-11-15 DOI: 10.1080/17581869.2024.2427944
Shubhadeep D Sinha, Tadikonda Bhavani Prasad, Bhaskar Konatham, Sreenivasa Chary Sriramadasu, Arnab Karmakar, Arun Kumar Sharma, Rakesh Verma, Srinivas Reddy Devireddy, Mohan Reddy Bandi, Muralidhar Panapakam
{"title":"Polmacoxib 2mg in patients with mild to moderate idiopathic osteoarthritis of hip/knee-a randomized, double-anonymous study.","authors":"Shubhadeep D Sinha, Tadikonda Bhavani Prasad, Bhaskar Konatham, Sreenivasa Chary Sriramadasu, Arnab Karmakar, Arun Kumar Sharma, Rakesh Verma, Srinivas Reddy Devireddy, Mohan Reddy Bandi, Muralidhar Panapakam","doi":"10.1080/17581869.2024.2427944","DOIUrl":"10.1080/17581869.2024.2427944","url":null,"abstract":"<p><strong>Aim: </strong>Polmacoxib, a new COX-2 inhibitor with carbonic anhydrase (CA) inhibitory action, is expected to help minimize the adverse effects associated with other NSAIDs, like GI (gastrointestinal) and CV (cardiovascular) system- related issues. The comparative efficacy and safety of polmacoxib 2 mg (manufactured by Hetero Labs Limited) versus celecoxib 200 mg (manufactured by Hetero Labs Limited) were assessed in this randomized, double-anonymous, clinical study in Indian adult patients diagnosed with idiopathic osteoarthritis (OA) of the.</p><p><strong>Patients & methodology: </strong>18 years and older patients of either sex, clinically and radiographically diagnosed idiopathic knee or hip OA were randomized to receive either polmacoxib or celecoxib in a 1:1 ratio. All patients were assessed with various pain measuring scales and recorded the scores at the end of weeks 3 and 6.</p><p><strong>Conclusion: </strong>The data for all the pain assessment scores were analyzed, and polmacoxib was found to be a non-inferior therapeutic agent compared to celecoxib in terms of safety and efficacy.(https://ctri.nic.in/CTRI/2022/05/042923).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"497-506"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation. 经颅直流电刺激后膝关节骨关节炎有反应者与无反应者的比较。
IF 1.4
Pain management Pub Date : 2024-09-01 Epub Date: 2024-11-16 DOI: 10.1080/17581869.2024.2429943
Juyoung Park, Heling Tong, Yixin Kang, Hongyu Miao, Lifeng Lin, Rina S Fox, Ilknur Telkes, Geraldine Martorella, Hyochol Ahn
{"title":"Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation.","authors":"Juyoung Park, Heling Tong, Yixin Kang, Hongyu Miao, Lifeng Lin, Rina S Fox, Ilknur Telkes, Geraldine Martorella, Hyochol Ahn","doi":"10.1080/17581869.2024.2429943","DOIUrl":"10.1080/17581869.2024.2429943","url":null,"abstract":"<p><strong>Aim: </strong>The study compared responders and nonresponders to transcranial direct current stimulation (tDCS) regarding clinical pain outcomes in knee osteoarthritis (OA) patients.</p><p><strong>Patients and methods/materials: </strong>Sixty participants received home-based active tDCS, and clinical pain outcomes were compared between responders and nonresponders.</p><p><strong>Results: </strong>Latent class growth analyses classified 41 participants as responders and 19 as nonresponders. Responders showed significantly greater decreases in pain intensity from baseline to post intervention than nonresponders (<i>p</i> < .001). Participants with higher BMI (<i>p</i> = .02) and weight (<i>p</i> = .005) were more likely to respond, while no significant sociodemographic differences were found.</p><p><strong>Conclusions: </strong>Identifying characteristics of nonresponsive tDCS subgroups can tailor treatments for each group.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT04016272.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"507-518"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review. 尼泊尔重度烧伤女患者的烧伤疼痛管理：病例研究与综述。
IF 16.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-05 DOI: 10.1080/17581869.2024.2382072
Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc
{"title":"Burn pain management in a female patient with severe burn injuries in Nepal: a case study and review.","authors":"Sundar Adhikari, Roshani Gurung, Suresh Bastakoti, Alian A Alrasheedy, Bhuvan Kc","doi":"10.1080/17581869.2024.2382072","DOIUrl":"10.1080/17581869.2024.2382072","url":null,"abstract":"<p><p>Burn injuries in low-resource settings like Nepal present significant public health challenges, leading to substantial morbidity, mortality and severe pain. This paper assesses burn pain management in Nepal, emphasizing the need for enhanced strategies. A case study of a female patient with severe burn injuries from a rural village in Western Nepal illustrates current challenges. Reviewing studies on burn pain management in Nepal shows limited access to specialized facilities, inadequate palliative care, medication shortages and insufficient healthcare professionals. Pharmacological interventions are impacted by financial constraints and a lack of protocols, while nonpharmacological approaches have not been explored and contextualized for the Nepalese context due to similar financial issues. Comprehensive burn pain management requires addressing resource constraints through collaborative health-aid partnerships.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"323-329"},"PeriodicalIF":16.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidural spread of surgical site infection from spinal cord stimulation trial. 脊髓刺激试验引起的手术部位感染的硬膜外扩散。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-08 DOI: 10.1080/17581869.2024.2373044
Taif Mukhdomi, Bennett Andrassy, Semih Gungor
{"title":"Epidural spread of surgical site infection from spinal cord stimulation trial.","authors":"Taif Mukhdomi, Bennett Andrassy, Semih Gungor","doi":"10.1080/17581869.2024.2373044","DOIUrl":"10.1080/17581869.2024.2373044","url":null,"abstract":"<p><p>We present a case of deep surgical site infection (SSI) at a spinal cord stimulator (SCS) trial implantation site, resulting from an allergic reaction to an unknown agent. A 38-year-old female with complex regional pain syndrome began an SCS trial, noting 100% pain relief for 5 days. Fluid drainage from the surgical site was reported on POD6 and trial leads were removed the following day. The patient was hospitalized with sepsis. Blood cultures revealed <i>Staphylococcus aureus</i>. MRIs showed skin breakdown and cellulitis of the paraspinal musculature extending into the epidural space. The patient was maintained with antibiotics and rigorous wound care for 9 days and the surgical site infection resolved. The patient proceeded to SCS implantation, and reported good pain relief with the implanted device.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"235-240"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions. 原发性痛经相关疼痛的自我管理：非药物干预横断面研究。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-23 DOI: 10.1080/17581869.2024.2376519
Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso
{"title":"Self-management of primary dysmenorrhea-related pain: cross-sectional study on non-pharmacological interventions.","authors":"Jéssica Cordeiro Rodrigues, Guilherme Tavares de Arruda, Pâmela Calixto de Moraes, Caren Beatriz Firão, Mariana Arias Avila, Patricia Driusso","doi":"10.1080/17581869.2024.2376519","DOIUrl":"10.1080/17581869.2024.2376519","url":null,"abstract":"<p><p><b>Aim:</b> Different nonpharmacological strategies are adopted to decrease primary dysmenorrhea (PD)-related pain. The present study aimed to verify women's use of nonpharmacological methods for pain and compare them with evidence from the literature.<b>Materials & methods:</b> A two-step study was conducted, comprising an online survey with 9144 women to assess nonpharmacological strategies for relieving PD-related pain, and a literature review on PubMed of verify the evidence of nonpharmacological methods.<b>Results:</b> Many women reported using heat therapy (61.5%), tea (42.4%) and massage (30.9%) to alleviate menstrual pain. However, the literature on these methods is limited.<b>Conclusion:</b> Several nonpharmacological methods are used by women to relieve PD-related pain and studies with low bias risk are needed to prove their effectiveness.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"265-272"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature difference between the affected and unaffected limbs in complex regional pain syndrome. 复杂性区域疼痛综合征患肢与非患肢之间的温差。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-08-08 DOI: 10.1080/17581869.2024.2377950
Burcu Candan, Semih Gungor
{"title":"Temperature difference between the affected and unaffected limbs in complex regional pain syndrome.","authors":"Burcu Candan, Semih Gungor","doi":"10.1080/17581869.2024.2377950","DOIUrl":"10.1080/17581869.2024.2377950","url":null,"abstract":"<p><p><b>Background:</b> Complex regional pain syndrome (CRPS) is classified into two subtypes based on clinical presentation: warm or cold.<b>Methods:</b> We examined the distribution of warm and cold subtypes in CRPS patients before they received lumbar sympathetic block. We retrospectively analyzed 81 prelumbar sympathetic block Forward Looking InfraRed images obtained from 30 patients to study temperature asymmetry between affected and unaffected limbs.<b>Results:</b> In 23 of the 30 patients (77%), the temperature difference between the affected and affected limbs was within the normal range (<0.6°C difference). Of the remaining seven cases, six (20%) were diagnosed with cold-CRPS and one (3%) with warm-CRPS. During subsequent interventions, 74% of the patients maintained a temperature difference within the normal range (<0.6°C difference).<b>Conclusion:</b> Retrospective analysis of Forward Looking InfraRed thermal camera images in CRPS patients showed that 77% of patients did not exhibit significant temperature asymmetry (<0.6°C difference) between affected and unaffected limbs.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"293-303"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics and predictors of pain among women who underwent cesarean section in Fiji. 斐济剖腹产妇女疼痛的特征和预测因素。
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-09 DOI: 10.1080/17581869.2024.2370757
Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan
{"title":"Characteristics and predictors of pain among women who underwent cesarean section in Fiji.","authors":"Ravneel Narayan, Masoud Mohammadnezhad, Nikansha Kumar, Sabiha Khan","doi":"10.1080/17581869.2024.2370757","DOIUrl":"10.1080/17581869.2024.2370757","url":null,"abstract":"<p><p><b>Aim:</b> To identify the characteristics and predictors of post cesarean section (CS) pain among women.<b>Materials & methods:</b> This quantitative study was conducted at Labasa hospital in Fiji over a 6-month period. A total of 312 mothers who received spinal, epidural and general anesthesia were included. Their pain score was assessed using the visual analogue scale 24 h postoperatively.<b>Results:</b> 70.8% women had either moderate or severe pain on the visual analogue scale. About 41.3% women expressed dissatisfaction with their pain management and 70.5% women had difficulties in performing activities due to pain. Lower parity was noted to be a positive predictor of pain among women undergoing CS.<b>Conclusion:</b> Adequate pain management for post-CS patient at Labasa hospital is lacking.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"283-291"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PPARγ and AKt gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy. 普瑞巴林和度洛西汀联合治疗糖尿病疼痛性多发性神经病变后的 PPARγ 和 AKt 基因调节作用
IF 1.4
Pain management Pub Date : 2024-06-02 Epub Date: 2024-07-12 DOI: 10.1080/17581869.2024.2370758
Ashok K Saxena, Nimisha Thanikkal, Geetanjali T Chilkoti, Prakash G Gondode, Tusha Sharma, Basu D Banerjee
{"title":"<i>PPARγ</i> and <i>AKt</i> gene modulation following pregabalin and duloxetine combination for painful diabetic polyneuropathy.","authors":"Ashok K Saxena, Nimisha Thanikkal, Geetanjali T Chilkoti, Prakash G Gondode, Tusha Sharma, Basu D Banerjee","doi":"10.1080/17581869.2024.2370758","DOIUrl":"10.1080/17581869.2024.2370758","url":null,"abstract":"<p><p><b>Aim:</b> Diabetic peripheral neuropathy (DPN) induces chronic neuropathic pain in diabetic patients. Current treatments like pregabalin and duloxetine offer limited efficacy. This study evaluates combining pregabalin and duloxetine versus pregabalin alone for DPN pain relief, and explores gene modulation (<i>PPARγ</i> and <i>Akt</i>) to understand neuropathic pain's molecular basis.<b>Materials & methods:</b> Diabetic patients with DPN were randomized into groups receiving combination therapy or pregabalin alone for 4 weeks. Pain intensity, gene expression and quality of life were assessed.<b>Results:</b> Combination therapy significantly reduced pain, improved quality of life and upregulated <i>PPARγ</i> and <i>Akt</i> genes compared with monotherapy.<b>Conclusion:</b> Pregabalin and duloxetine combination therapy in DPN led to <i>PPARγ</i> mRNA upregulation and negative correlation of <i>Akt</i> gene expression with pain scores. This combination therapy effectively reduced pain and improved quality of life.<b>Clinical Trial Registration:</b> CTRI/2021/02/031068.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"273-281"},"PeriodicalIF":1.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141591014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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