Pain management最新文献_第5页

Correction. 修正。

IF 1.7

Pain management Pub Date : 2026-09-04 DOI: 10.1080/17581869.2026.2728794

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Protocol for a prospective single-arm feasibility study of suzetrigine for postoperative pain management in outpatient facial plastic surgery. 一项前瞻性单臂可行性研究方案：舒三嗪用于门诊面部整形手术术后疼痛管理。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-05-19 DOI: 10.1080/17581869.2026.2676101

Bastien A Valencia-Sanchez, Matthew M Colontonio, Deanna C Menapace

{"title":"Protocol for a prospective single-arm feasibility study of suzetrigine for postoperative pain management in outpatient facial plastic surgery.","authors":"Bastien A Valencia-Sanchez, Matthew M Colontonio, Deanna C Menapace","doi":"10.1080/17581869.2026.2676101","DOIUrl":"10.1080/17581869.2026.2676101","url":null,"abstract":"Despite relatively brief postoperative pain courses and well-established risks of adverse effects and dependency, opioid analgesics remain routinely prescribed following outpatient facial plastic surgery. Suzetrigine (Journavx) is a first-in-class, oral, non-opioid analgesic that selectively inhibits the voltage-gated sodium channel 1.8 (NaV1.8), a peripheral nociceptive pathway target that may avoid central nervous system adverse effects associated with opioids. While suzetrigine has demonstrated efficacy in phase III trials of acute postoperative pain, its use in facial plastic surgery has not been studied. This prospective, single-arm feasibility study will evaluate the practicality of incorporating suzetrigine into multimodal postoperative analgesia regimens of adults undergoing outpatient facial plastic surgery. Primary feasibility outcomes include recruitment rate, treatment adherence, and compliance with postoperative pain reporting. Prespecified feasibility benchmarks include recruitment of at least 60% of eligible patients approached for participation, treatment adherence in at least 80% of enrolled participants, and postoperative pain questionnaire completion in at least 70% of participants. Exploratory clinical outcomes include opioid utilization during the first postoperative week, postoperative pain intensity, functional recovery, patient satisfaction, and incidence of adverse events. Findings from this study will provide preliminary data to inform the design of future prospective trials evaluating opioid-sparing analgesic strategies in facial plastic surgery.Clinical Trial Registration: The www.clinicaltrials.gov identifier is NCT07257133.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"957-962"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Response to comment on "Nutrition care in pain rehabilitation-success and lessons from practice". 对“疼痛康复中的营养护理——成功与实践教训”评论的回应。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-04-20 DOI: 10.1080/17581869.2026.2661842

Huan-Ji Dong, Anna Wahl, Maria Henström Engblom, Marie Löf, Lucy Kocanda, Katherine Brain, Bijar Ghafouri

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Comment on "Nutrition care in pain rehabilitation-success and lessons from practice". 评《疼痛康复中的营养护理——成功与实践教训》

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-04-20 DOI: 10.1080/17581869.2026.2661843

Meer M Abdulkarim, Sherzad W Mahmood, Fahmi H Kakamad

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Ultrasound guided bilateral superficial cervical plexus block versus intravenous ketamine and dexmedetomidine infusion as opioid sparing analgesia for upper tracheal resection and reconstruction surgeries: a randomized comparative study. 超声引导双侧颈浅丛阻滞与静脉注射氯胺酮和右美托咪定作为阿片类药物保留镇痛用于上气管切除和重建手术的随机比较研究。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-06-09 DOI: 10.1080/17581869.2026.2685605

Mohammed N Mohammed, Ahmed M Mohasseb, Reem A Elsharkawy, Aly E Rashad

{"title":"Ultrasound guided bilateral superficial cervical plexus block versus intravenous ketamine and dexmedetomidine infusion as opioid sparing analgesia for upper tracheal resection and reconstruction surgeries: a randomized comparative study.","authors":"Mohammed N Mohammed, Ahmed M Mohasseb, Reem A Elsharkawy, Aly E Rashad","doi":"10.1080/17581869.2026.2685605","DOIUrl":"10.1080/17581869.2026.2685605","url":null,"abstract":"Introduction: A common indication for tracheal resection and reconstruction (TRR) is tracheal stenosis secondary to prolonged intubation. The objective of this trial is to evaluate the efficacy of bilateral superficial cervical plexus block (BSCPB) compared with IV infusion of ketamine and dexmedetomidine as opioid-sparing analgesic approaches for TRR.Materials and methods: 66 patients scheduled for TRR were randomized to receive either BSCPB (BSCP group) or an IV infusion of ketamine and dexmedetomidine (KD group). The primary outcome was the duration of analgesia. Secondary outcomes were 24-hour postoperative fentanyl consumption, VAS scores at 2, 4, 6, 12, and 24 hours postoperatively, postoperative agitation score, and complications.Results: The BSCP group had a mean analgesic duration of 10.39 ± 2.50 hours, whereas the KD group had a mean of 6.02 ± 1.89 hours. The VAS score was significantly lower in the BSCP group than in the KD group at 4, 6, 8, and 12 hours post-operatively. The KD group received a larger Fentanyl dose than the BSCP group.Conclusion: Ultrasound-guided BSCPB demonstrated a superior analgesic profile with less opioid consumption, with no differences in reported complications.Clinical trial registration: The pactr.samrc.ac.za identifier is PACTR202408626945341.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"995-1001"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148212099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging adverse event signals of new analgesic suzetrigine: a disproportionality analysis of the FAERS database. 新型镇痛药苏三嗪的新出现的不良事件信号：FAERS数据库的歧化分析。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-05-17 DOI: 10.1080/17581869.2026.2675485

Slobodan M Janković, Snežana V Janković

{"title":"Emerging adverse event signals of new analgesic suzetrigine: a disproportionality analysis of the FAERS database.","authors":"Slobodan M Janković, Snežana V Janković","doi":"10.1080/17581869.2026.2675485","DOIUrl":"10.1080/17581869.2026.2675485","url":null,"abstract":"Background: Suzetrigine, new non-opioid analgesic, does not cause respiratory depression and dependence, the main limiting factors for the use of opioids; however, its complete safety profile is not yet established.Objective: The aim of this study is first to review the adverse effects of suzetrigine published so far, and then to analyze the spontaneous reports of adverse events for suzetrigine in the FAERS database to identify possible signals of hitherto unknown adverse effects.Methods: The study's outcomes were the four standard disproportionality indices calculated for each adverse event reported: Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Yule's Q, and Information Component (IC).Results: There are four signals of possible adverse effects of suzetrigine: paresthesia (ROR 19.62 ± 5.69, PRR 1.38 ± 0.36, IC 4.18 ± 0.41, Yules Q 0.90 ± 0.03), burning sensations (ROR 15.75 ± 7.26, PRR 2.43 ± 1.08, IC 3.93 ± 0.64, Yules Q 0.88 ± 0.05), a swollen tongue (ROR 13.04 ± 10.66, PRR 4.95 ± 4.00, IC 3.68 ± 1.08, Yules Q 0.86 ± 0.10), and abnormal dreams (ROR 23.49 ± 17.81, PRR 13.97 ± 10.44, IC 4.53 ± 1.01, Yules Q0.92 ± 0.06).Conclusions: After the first year of widespread use of suzetrigine, there are only a few signals of possible side effects that were not observed in clinical studies, of which paresthesias have the highest probability of being a real side effect.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1003-1007"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplifying the effects of comprehensive exercise through pre-exercise expectation framing in patients with knee osteoarthritis: study protocol for an assessor-blinded randomized controlled trial. 通过运动前预期框架放大膝骨关节炎患者综合运动的效果：评估盲随机对照试验的研究方案

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-05-26 DOI: 10.1080/17581869.2026.2676725

Maryam Bagheri Mahmoudi, Amir Letafatkar, Malihe Hadadnezhad, Seyed Sadredin Shojaedin, Giacomo Rossettini

{"title":"Amplifying the effects of comprehensive exercise through pre-exercise expectation framing in patients with knee osteoarthritis: study protocol for an assessor-blinded randomized controlled trial.","authors":"Maryam Bagheri Mahmoudi, Amir Letafatkar, Malihe Hadadnezhad, Seyed Sadredin Shojaedin, Giacomo Rossettini","doi":"10.1080/17581869.2026.2676725","DOIUrl":"10.1080/17581869.2026.2676725","url":null,"abstract":"Introduction: Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide. Although exercise therapy is recommended as first-line treatment, outcomes vary considerably. Treatment expectations may influence rehabilitation response. This randomized controlled trial (RCT) protocol investigates whether brief pre-exercise expectation framing affects pain and functional outcomes in individuals with KOA undergoing structured rehabilitation.Methods: This assessor-blinded, three-arm superiority RCT will recruit 90 participants with symptomatic, radiographically confirmed KOA from the outpatient physiotherapy department of Kharazmi University, Tehran, Iran. Participants will be randomized (1:1:1) to receive comprehensive knee exercises combined with positive, negative, or neutral expectation framing. All groups will complete an 18-session supervised exercise program over six weeks. Expectation framing will be delivered once before the first session. Primary outcomes are pain intensity and disability. Secondary outcomes include knee kinematics, muscle activity, pain catastrophizing, self-efficacy, kinesiophobia, and treatment expectations. Assessments will be conducted at baseline, post-intervention, and three-month follow-up; expectation ratings will also be collected immediately after framing to verify the manipulation.Discussion: This trial will evaluate whether pre-exercise expectation framing influences rehabilitation outcomes in KOA and clarify the role of treatment expectations in clinical practice.Clinical trial registration: The http://www.irct.ir identifier is IRCT20250811066819N1.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"971-983"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific and shared mechanisms associated with treatment for chronic neck pain: the SS-MECH mechanistic clinical trial. 与慢性颈部疼痛治疗相关的特定和共享机制：SS-MECH机制临床试验

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-06-08 DOI: 10.1080/17581869.2026.2685609

Chad E Cook, Bryan O'Halloran, Derek Clewley, Frances Keefe, Amy McDevitt

{"title":"Specific and shared mechanisms associated with treatment for chronic neck pain: the SS-MECH mechanistic clinical trial.","authors":"Chad E Cook, Bryan O'Halloran, Derek Clewley, Frances Keefe, Amy McDevitt","doi":"10.1080/17581869.2026.2685609","DOIUrl":"10.1080/17581869.2026.2685609","url":null,"abstract":"Introduction: The effects of interventions such as manual therapy (MT) and exercise on chronic neck pain (CNP) are thought to work through different specific mechanisms. However, randomized clinical trials comparing MT and exercise frequently demonstrate similar outcomes, suggesting the possibility of shared mechanisms. Objectives: To compare specific and shared mechanisms (primary) and clinical outcomes (secondary) across patients randomized to an MT or an exercise treatment group for CNP.Methods: A mechanistic clinical trial consented and randomized 124 participants with CNP. Mechanistic measures assessing mobility, pain modulation, endurance, self-efficacy, therapeutic alliance, clinical engagement, fear, and positive coping were captured at baseline, at 2-weeks and at 3-weeks. Clinical outcomes for pain interference, intensity and physical function were gathered at baseline, 4-weeks, and 6-months. Differences between treatment groups were analyzed using repeated-measures, linear mixed effects models.Results: There were no significant differences between groups in any of the mechanistic measures, although significant changes occurred over time. Between-group differences were observed favoring MT at 4 weeks for physical function.Discussion/conclusion: MT and exercise produced comparable effects on both specific and shared mechanisms, as well as a majority of clinical outcomes. Collectively, the results support the notion that MT and exercise are influenced by common mechanisms.Clinical trial registration: The www.clinicaltrials.gov identifier is NCT05940012.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1009-1017"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and implementation of multidisciplinary care model to address the intersection of pain and opioid use disorder among patients on long term opioid treatment. 多学科护理模式的发展和实施，以解决长期阿片类药物治疗患者疼痛和阿片类药物使用障碍的交叉问题。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-06-16 DOI: 10.1080/17581869.2026.2686786

Sarah Humphreys, Vani George, Tessa Gomez, Sanjana Koshy, Jessica Robinson-Papp, Ashly E Jordan, David C Perlman

{"title":"Development and implementation of multidisciplinary care model to address the intersection of pain and opioid use disorder among patients on long term opioid treatment.","authors":"Sarah Humphreys, Vani George, Tessa Gomez, Sanjana Koshy, Jessica Robinson-Papp, Ashly E Jordan, David C Perlman","doi":"10.1080/17581869.2026.2686786","DOIUrl":"10.1080/17581869.2026.2686786","url":null,"abstract":"Background: Chronic non-cancer pain and opioid use disorder (OUD) are common co-morbidities. Clinical guidelines and regulatory changes have created challenges for providers and programs in which chronic pain and OUD treatment may be sub-optimally integrated for patients receiving long-term opioid therapy (LTOT).Methods: We identified a cohort of 61 patients in HIV primary care who met criteria for LTOT (i.e. prescribed opioids for chronic non-cancer pain >90 days) and who experienced disruptions in pain management and present an analytic case study. A multidisciplinary team developed a two-step intervention to mitigate withdrawal and overdose risk and to facilitate ongoing safe, effective pain management.Results: Among 61 patients, 29.5% were receiving methadone for pain and 9.8% were receiving LTOT for pain while enrolled in methadone OUD treatment programs. All 61 LTOT patients were referred for pain management reassessment. The following assessments were made: 24.6% had chronic pain without OUD; 9.8% had OUD and transitioned to OUD treatment; 3.3% self-elected to stop opioids; 29.5% were consensually initiated on a slow consensual opioid tapering schedule.Conclusions: A multidisciplinary intervention can provide overdose risk mitigation, facilitate pain and OUD re-assessments and can guide ongoing management of cohorts of patients previously maintained on LTOT for chronic non-cancer pain.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"985-993"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148259223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Painless palsy" revisited: a systematic review of pain in hereditary neuropathy with liability to pressure palsies. “无痛性麻痹”重访：遗传性神经病变伴压迫性麻痹疼痛的系统回顾。

IF 1.7

Pain management Pub Date : 2026-09-01 Epub Date: 2026-05-21 DOI: 10.1080/17581869.2026.2676099

Floris V Raasveld, Fernando J Pacheco, Arya S Rao, Eva Godina, David Hao, Ian L Valerio, Benjamin R Johnston, Kyle R Eberlin

{"title":"\"Painless palsy\" revisited: a systematic review of pain in hereditary neuropathy with liability to pressure palsies.","authors":"Floris V Raasveld, Fernando J Pacheco, Arya S Rao, Eva Godina, David Hao, Ian L Valerio, Benjamin R Johnston, Kyle R Eberlin","doi":"10.1080/17581869.2026.2676099","DOIUrl":"10.1080/17581869.2026.2676099","url":null,"abstract":"Objectives: Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) has long been described as a disorder of \"painless palsies,\" shaping diagnostic and therapeutic paradigms. Increasing evidence suggests this characterization underestimates the true burden of pain in HNPP.Methods: We systematically reviewed literature to examine how pain recognition and characterization in HNPP have evolved. MEDLINE, Embase, Web of Science, and CENTRAL were searched from database inception through August 2025 for studies explicitly reporting pain status. Data on pain prevalence, assessment methods, temporal trends, and associated clinical features were extracted. Studies were grouped into three eras reflecting diagnostic advances: early (≤1990; clinical diagnosis only), modern (1990-2015; introduction of genetic testing), and recent (≥2015; widespread use of genetic panels).Results: Fifty-three studies comprising 655 patients met inclusion criteria. Reported pain prevalence increased over time, from reinforcing a \"painless\" paradigm in early studies to 34% in modern studies and 56% in recent studies. Recent studies more frequently identified complex neuropathic pain phenotypes. Only four studies (7.5%) used validated pain assessment tools, yet consistently reported higher prevalence and greater symptom complexity.Conclusion: HNPP is not uniformly painless. Pain is common, clinically relevant, and multifactorial, highlighting the need for standardized pain assessment to guide management.","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1037-1055"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0