Pain managementPub Date : 2025-10-01Epub Date: 2025-07-18DOI: 10.1080/17581869.2025.2535270
Özge Özpolat Bulut, Mevlüt Özmen, Faisal Al Ali, Ismael Shaukat, Fatih Bağcıer
{"title":"Academic and societal impact of cancer pain research: a bibliometric and Altmetric Analysis.","authors":"Özge Özpolat Bulut, Mevlüt Özmen, Faisal Al Ali, Ismael Shaukat, Fatih Bağcıer","doi":"10.1080/17581869.2025.2535270","DOIUrl":"10.1080/17581869.2025.2535270","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related pain affects quality of life despite advancements in management. Bibliometric and altmetric analyses provide insights into the academic and societal impact of research.</p><p><strong>Objective: </strong>This study analyzed the top 100 most-cited articles on cancer-related pain using bibliometric and altmetric indicators, exploring correlations between altmetric scores, citations per year, and total citations.</p><p><strong>Methods: </strong>A search of the Web of Science Core Collection database was conducted on 2 November 2024, to identify articles related to cancer pain published between 1975 and 2024. The top 100 most-cited articles were selected based on total citation counts. Only English-language articles with full-text access were included. Bibliometric data were collected. Altmetric scores were retrieved using the Altmetric Explorer platform, and correlations were assessed using Spearman's test.</p><p><strong>Results: </strong>The 100 most-cited articles appeared in 35 journals, with PAIN contributing the most (<i>n</i> = 19). Total citations and citations per year showed a strong correlation (<i>r</i> = 0.64), but the correlation between altmetric scores and total citations was weak (<i>r</i> = 0.18).</p><p><strong>Conclusion: </strong>This study highlights the academic and societal impact of cancer pain research. The weak correlation between citations and altmetric scores suggests a need for better dissemination strategies to enhance public engagement.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"693-702"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-10-01Epub Date: 2025-08-21DOI: 10.1080/17581869.2025.2550931
Oreste Marsico, Marta Lioi, Michele Trimboli
{"title":"Late response to anti-CGRP therapy for migraine.","authors":"Oreste Marsico, Marta Lioi, Michele Trimboli","doi":"10.1080/17581869.2025.2550931","DOIUrl":"10.1080/17581869.2025.2550931","url":null,"abstract":"<p><p>Migraine is a debilitating neurological disorder affecting 1 billion people worldwide. Traditional preventive drugs showed low efficacy and poor tolerability. Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptors offer a new efficacious and safe therapeutic option for migraine patients. According to randomized controlled trials, these disease-specific drugs reduce migraine frequency by ≥ 50% within 3 months. However, real-world studies show that some patients require a longer treatment duration (6 or 12 months). This narrative review aimed to investigate the occurrence of late and ultra-late responses to anti-CGRP therapy, exploring their potential mechanisms and clinical significance. A literature search was performed [PubMed, Web of Science and Google Scholar; publications up to July 2025] to identify relevant studies for this narrative review. Across 10 real-world studies, a proportion of patients who did not respond at 3 months achieved a meaningful clinical response at later time points: some between 3 and 6 months (\"late responders\") and others between 6 and 12 months (\"ultra-late responders\"). Around one-third of initial non-responders improved by 6 months, and among those who remained non-responsive at that point, a further proportion benefited by 12 months. The pathophysiological mechanism behind late response is a field of investigation, and the interaction of anti-CGRPs on the process of central desensitization seems to be crucial. Our review underscores the need to extend treatment beyond the typical 3-month period to attain meaningful benefits from anti-CGRP therapies.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"745-751"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-10-01Epub Date: 2025-09-03DOI: 10.1080/17581869.2025.2549238
Mark I Johnson
{"title":"Delayed adverse skin reaction to transcutaneous electrical nerve stimulation (TENS) electrodes.","authors":"Mark I Johnson","doi":"10.1080/17581869.2025.2549238","DOIUrl":"10.1080/17581869.2025.2549238","url":null,"abstract":"<p><p>A 76-year-old woman developed a delayed allergic reaction to adhesive pads following home use of transcutaneous electrical nerve stimulation (TENS) for pain management after a complex elbow dislocation. This case highlights the potential for delayed hypersensitivity reactions to TENS electrode pads. Although formal allergology testing was not performed, the woman's self-directed observations offered valuable insight. The clinical presentation and timing of symptom onset were more consistent with allergic rather than irritant contact dermatitis. Allergic contact dermatitis from TENS pads is often linked to specific allergens in the adhesive materials. Hypoallergenic alternatives aim to reduce this risk by eliminating or substituting known sensitizers. Interestingly, the reaction on the painful arm - where titanium plates had been surgically implanted - extended beyond the electrode placement, whereas on the unaffected, pain-free leg, it remained localized. This suggests that local tissue conditions may modulate the immune response. This case demonstrates the importance of clinician awareness regarding potential dermatological adverse events associated with TENS therapy and emphasizes the need for patient education, particularly when TENS is administered independently. Further investigation into the interaction between local inflammatory states and immune reactivity may inform safer electrode design and guide clinical recommendations for safe TENS use.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"671-676"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-10-01Epub Date: 2025-07-22DOI: 10.1080/17581869.2025.2535272
Cristiano Carvalho, Patricia Gabrielli Vassão, Thatiane Izabele Ribeiro Santos, Alice Torres Pontes, Julia Ghraziely Justino de Oliveira, Catharina Marabiza Pinheiro, Maria Eduarda de Sousa Kawabe, Bruna Genari Sena, Carlos Eduardo Pinfildi, Victor Zuniga Dourado, Ricardo Luís Fernandes Guerra, Mariana Arias Avila Vera, Ana Claudia Muniz Renno
{"title":"Combined aerobic exercise and photobiomodulation for pain and other symptoms in fibromyalgia: study protocol.","authors":"Cristiano Carvalho, Patricia Gabrielli Vassão, Thatiane Izabele Ribeiro Santos, Alice Torres Pontes, Julia Ghraziely Justino de Oliveira, Catharina Marabiza Pinheiro, Maria Eduarda de Sousa Kawabe, Bruna Genari Sena, Carlos Eduardo Pinfildi, Victor Zuniga Dourado, Ricardo Luís Fernandes Guerra, Mariana Arias Avila Vera, Ana Claudia Muniz Renno","doi":"10.1080/17581869.2025.2535272","DOIUrl":"10.1080/17581869.2025.2535272","url":null,"abstract":"<p><strong>Trial registration: </strong>RBR-3pxmycv. This study protocol was registered in ensaiosclinicos.gov.br (Brazilian Registry of Clinical Trials), published on 19 December 2023, https://ensaiosclinicos.gov.br/rg/RBR-3pxmycv.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"637-649"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-10-01Epub Date: 2025-08-06DOI: 10.1080/17581869.2025.2542719
Yann Gricourt, Philippe Cuvillon, Patrice Forget
{"title":"Opioid-free anaesthesia as a valuable alternative to opioid-based practices: evidence and future challenges.","authors":"Yann Gricourt, Philippe Cuvillon, Patrice Forget","doi":"10.1080/17581869.2025.2542719","DOIUrl":"10.1080/17581869.2025.2542719","url":null,"abstract":"<p><p>Opioid-Free-Anesthesia (OFA) offers a valuable alternative model that challenges traditional opioid-based anesthesia practices. Recent studies have tempered expectations regarding the capacity of OFA techniques to improve quality of postoperative pain management and early recovery, in contrast with the clearly decreased risk of postoperative nausea and vomiting. Essentially based on regional anesthesia, non-opioid adjuvants and multimodal analgesia, OFA should be better viewed as a menu rather than a recipe, guided by surgical invasiveness, patient background, expected postoperative pain, and the practitioner's expertise. Potential concerns of OFA, including bradycardia and hypotension, are manageable with proper training and adapted dosing. Further multicentre trials and non-inferiority studies are needed to better define OFA's impact on patient-reported outcome and experiences measures in perioperative care.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"721-731"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-09-30DOI: 10.1080/17581869.2025.2567832
Jie Liu, Li Li, Lan Luo, Na Wu, Fang Xu, Chengkun Tao, Jie Chen, He Huang, Guangyou Duan
{"title":"Effect of coenzyme Q10 on pain prevention after thoracoscopic surgery: study protocol.","authors":"Jie Liu, Li Li, Lan Luo, Na Wu, Fang Xu, Chengkun Tao, Jie Chen, He Huang, Guangyou Duan","doi":"10.1080/17581869.2025.2567832","DOIUrl":"https://doi.org/10.1080/17581869.2025.2567832","url":null,"abstract":"<p><strong>Clinicaltrial registration: </strong>www.clinicaltrials.gov identifier is NCT06743802.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145192288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-09-20DOI: 10.1080/17581869.2025.2561399
Adam Ricker, Nicole Farley, Jesse J McClure, Lisa Goudman, Deepak Berwal, Olga Khazen, Ilknur Telkes, Umm E Hani Abdullah, Candy Wilson, Julie G Pilitsis
{"title":"Chronic pain prevalence and severity in females before & after menopause versus males in a large multi-center database.","authors":"Adam Ricker, Nicole Farley, Jesse J McClure, Lisa Goudman, Deepak Berwal, Olga Khazen, Ilknur Telkes, Umm E Hani Abdullah, Candy Wilson, Julie G Pilitsis","doi":"10.1080/17581869.2025.2561399","DOIUrl":"https://doi.org/10.1080/17581869.2025.2561399","url":null,"abstract":"<p><strong>Aims: </strong>This observational study aimed to explore the prevalence and severity of chronic pain in menopausal-aged females.</p><p><strong>Materials & methods: </strong>We identified participants in the NIH-sponsored All of Us database with a diagnosis of chronic pain. We examined the severity of pain based on numeric rating scale score (NRS). Among those with chronic pain, we generated four sub-cohorts: females ≥ 51 years old who were menopausal, females 18-50 years who were considered pre-menopausal, and age matched male cohorts.</p><p><strong>Results: </strong>The 53,289 participants were separated into four cohorts by age and sex: females 18-50 (10,269), females ≥ 51 (20,182), males 18-50 (4,989), and males ≥ 51 (17,849). Both older females and older males had lower pain levels than the sex-matched 18-50 group (<i>p</i> < 0.001). Findings were consistent in White, Black, and non-Hispanic cohorts. When comparing older adults, females ≥ 51 had higher pain levels than males ≥ 51 (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>We found that independent of sex, NRS scores were lower in older adults compared to younger cohorts. Older women however had more pain than their male counterparts. These findings have implications for the design of patient-tailored therapeutic treatments and warrant further exploration of physiological and psychosocial causes.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-6"},"PeriodicalIF":1.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of analgesia in cardiac surgery.","authors":"Alessandro Strumia, Mario Lusini, Fabio Costa, Elisabetta Stefani, Elena Cipollone, Livio Cusimano, Francesca Libri, Massimiliano Ricci, Alessandro Ruggiero, Domenico Sarubbi, Alessia Mattei, Lorenzo Schiavoni, Raffaele Barbato, Ciro Mastroianni, Mohamad Jawabra, Felice Eugenio Agrò, Massimo Chello, Rita Cataldo, Massimiliano Carassiti, Giuseppe Pascarella","doi":"10.1080/17581869.2025.2532359","DOIUrl":"10.1080/17581869.2025.2532359","url":null,"abstract":"<p><strong>Background: </strong>Pain management in cardiac surgery remains a critical component of perioperative care, influencing recovery, patient satisfaction, and outcomes. Traditional opioid-based analgesia is associated with significant adverse effects, prompting the exploration of multimodal strategies, including regional anesthesia (RA), non-opioid analgesics, and enhanced recovery after surgery (ERAS) protocols.This review evaluates the evolution of cardiac surgery pain management, from conventional opioid-based regimens to multimodal approaches with regional anesthesia.</p><p><strong>Methods: </strong>A comprehensive analysis of existing literature was conducted, assessing the efficacy, safety, and integration of different pain management strategies in cardiac surgery on PubMed, Google Scholar, MEDLINE, UpToDate, Embase and Web of Science until 1 November 2024. Studies on opioids, adjunct analgesics (e.g. NSAIDs, acetaminophen, ketamine, dexmedetomidine), RA techniques, and ERAS frameworks were reviewed to provide a comparative perspective.</p><p><strong>Results: </strong>Multimodal analgesia significantly reduces opioid consumption, enhances pain control, and minimizes complications such as respiratory depression and postoperative nausea. RA techniques, including fascial plane blocks, offer promising opioid-sparing benefits. ERAS protocols further optimize recovery, yet challenges remain in standardizing approaches across institutions.</p><p><strong>Conclusions: </strong>The future of cardiac surgery pain management lies in individualized, multimodal strategies following ERAS principles. Standardized guidelines and further research are needed to refine these protocols for widespread adoption.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"595-609"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-09-01Epub Date: 2025-07-07DOI: 10.1080/17581869.2025.2529773
Guy Feigin, Elad Dana, Victoria Bains, Anuj Bhatia
{"title":"Evaluating patient satisfaction and perceived accuracy in questionnaires completed before vs. during a pain clinic visit.","authors":"Guy Feigin, Elad Dana, Victoria Bains, Anuj Bhatia","doi":"10.1080/17581869.2025.2529773","DOIUrl":"10.1080/17581869.2025.2529773","url":null,"abstract":"<p><strong>Introduction: </strong>Effective assessment is essential for planning treatment in chronic pain management. This study compared patient satisfaction and perceived data accuracy between completing pre-assessment questionnaires at home versus in the clinic prior to a neuromodulation consultation.</p><p><strong>Methods: </strong>In this prospective, single-center study, adult patients referred for neuromodulation assessment were randomized to complete intake questionnaires either at home (\"Home\" group) or upon arrival at the clinic (\"Clinic\" group). Prior the appointment, all participants completed a satisfaction survey assessing perceived accuracy, time efficiency, and preference.</p><p><strong>Results: </strong>Forty-two patients participated (Home: 17; Clinic: 25). Overall satisfaction was not significantly different between groups (88.2% vs. 64%, <i>p</i> = 0.202). However, perceived response accuracy (88.2% vs. 36%, <i>p</i> < 0.001) and time efficiency (82.4% vs. 28%, <i>p</i> = 0.002) were significantly higher in the Home group. More than half of Clinic group participants stated they would have preferred to complete the questionnaires at home (52% vs. 5.9%, <i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>Completing pre-assessment questionnaires at home resulted in higher perceived accuracy and time efficiency without compromising satisfaction. These findings support incorporating remote pre-visit assessments into chronic pain clinic workflows to optimize patient experience.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT03852381.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"571-576"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial.","authors":"Zahra Nejati, Babak Ghadirzadeh, Hady Mohammadi, Maryam Afraie, Yousef Moradi","doi":"10.1080/17581869.2025.2528590","DOIUrl":"10.1080/17581869.2025.2528590","url":null,"abstract":"<p><strong>Aim: </strong>This study primarily aimed to evaluate the efficacy of Coenzyme Q10 supplementation in improving post-extraction tissue healing and, secondarily, its effects on reducing temporomandibular disorders (TMD), dry socket and enhancing quality of life following wisdom tooth extraction.</p><p><strong>Patients and methods: </strong>This parallel randomized, double-blind, placebo-controlled trial included 70 participants, randomly assigned to receive either CoQ10 or placebo. The primary outcome was tissue healing, measured by clinical assessments on days 7, 14 and 30 post-surgeries; alongside secondary outcomes including the occurrence of TMD and dry socket occurrence. Additional secondary outcomes included physical and psychological recovery, assessed using the 36-item short form survey (SF36) and the 12-item general health questionnaire (GHQ12), which measure psychological distress and health-related quality of life.</p><p><strong>Results: </strong>On day 7, the CoQ10 group showed a significant 45% improvement in tissue healing, compared to its counterpart and by day 14, showed a 55% improvement. TMD occurred in 12% of the CoQ10 group vs. 30% in the placebo group; and dry socket was 6% in the CoQ10 group vs. 18% in the placebo group.</p><p><strong>Conclusion: </strong>Coenzyme Q10 supplementation significantly accelerates tissue healing, reduces TMD and dry socket incidence and improves physical and mental health outcomes following wisdom tooth extraction.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov [registration number NCT06452134].</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"555-569"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}