Pain management最新文献

{"title":"Mapping evidence on psychosocial factors in patients with shoulder pain: a scoping review.","authors":"Lucas Araujo Almeida, Dalton Whitman, Germanna Medeiros Barbosa, Jane Morgan-Daniel, Bruno Mazuquin, Jason Beneciuk, Federico Pozzi","doi":"10.1080/17581869.2026.2736032","DOIUrl":"https://doi.org/10.1080/17581869.2026.2736032","url":null,"abstract":"<p><strong>Purpose: </strong>To map psychosocial factors investigated in adults with shoulder pain across community, primary, secondary, and tertiary care settings and summarize methodological quality.</p><p><strong>Materials and methods: </strong>This scoping review followed PRISMA-ScR guidance and was registered on the Open Science Framework. Ten databases and gray literature were searched through 10 March 2026. Observational studies and clinical trials assessing psychosocial factors in adults with shoulder pain were included. Two reviewers independently screened studies, extracted data, and evaluated risk of bias using the Newcastle-Ottawa Scale, AXIS, NIH tools, and RoB 2.0.</p><p><strong>Results: </strong>We included 345 studies, 310 identified through the primary search and an additional 35 identified through a secondary search targeting frozen shoulder (<i>n</i> = 1,909,198; 46% women, 51.9 ± 6.58 years old), mostly from high-income countries. Depression, anxiety, catastrophizing, and general mental health were most frequently assessed. Across recruitment sources, 18.5% of the studies were community-based, 12% were in primary care, 32.2% in secondary care, and 46.6% in tertiary care. Depression, catastrophizing, anxiety, and fear-avoidance predominated in community, primary, and secondary care, whereas tertiary care more often examined depression, anxiety, general mental health, and satisfaction. Positive factors were rarely measured.</p><p><strong>Conclusion: </strong>Community and early care settings primarily assessed psychological distress and pain-related beliefs, whereas tertiary care emphasized distress and cognitive factors. Positive psychosocial factors remain underrepresented, highlighting opportunities for a more comprehensive biopsychosocial characterization of shoulder pain. Twenty-two potentially eligible full-text articles could not be retrieved despite repeated attempts to contact the authors, which should be considered when interpreting the comprehensiveness of the evidence map.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare providers' perceptions and prescribing behaviors of short-term prevention treatment of migraine in the United States.","authors":"Teshamae S Monteith, Nemin Chen, Jessica Cirillo, Lucy Abraham, Aaron Jenkins, Phillip Saccone, Chelsea Leroue, Feng Dai, Karina Nakajima, Elizabeth McCaig, Jessica Ailani","doi":"10.1080/17581869.2026.2734046","DOIUrl":"https://doi.org/10.1080/17581869.2026.2734046","url":null,"abstract":"<p><strong>Aims: </strong>Short-term prevention (STP) therapies are used to prevent migraine during anticipated exposure to known triggers. However, little is known about healthcare providers' (HCPs) attitudes and prescribing practices regarding STP. This study aimed to characterize real-world STP treatment perceptions and prescribing behaviors among US HCPs.</p><p><strong>Materials and methods: </strong>US HCPs aware of STP treatment completed a cross-sectional survey (August-September 2024) assessing demographic and practice characteristics, STP perceptions, and patient factors considered when prescribing STP.</p><p><strong>Results: </strong>Over 90% of HCPs agreed that migraine treatment should provide patients with flexibility to control their attacks. Gepants were the most frequently prescribed STP treatment (71.9%), with rimegepant being the most prescribed gepant for STP (84.1%). Menstrual migraine (83.3%) and the ability to predict triggers (78.2%) were the most frequently considered patient characteristics. Primary care providers and nurse practitioners/physician assistants considered a wider array of patient factors than headache specialists and other neurologists.</p><p><strong>Conclusions: </strong>HCPs aware of STP believe patients with migraine, especially those with perimenstrual attacks, may benefit from STP treatment. Gepants were the most prescribed STP migraine treatment.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications of ReActiv8 for chronic low back pain: an analysis of the FDA MAUDE database.","authors":"Rosalynn R Z Conic, Tugba Kivanc, Azadeh Fischer, Sai K Pasya, Sharima Kanahan Osman, Daniel Wang, Scott Palmer, Eva Kubrova, Jason S Eldrige, Mark Friedrich Hurdle, Christine L Hunt, Sahil Gupta","doi":"10.1080/17581869.2026.2736037","DOIUrl":"https://doi.org/10.1080/17581869.2026.2736037","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic low back pain (CLBP) is a common multifactorial condition associated with- lumbar multifidus dysfunction and impaired neuromuscular control, which ReActiv8 addresses. As its use increases, real-world post-market adverse event data are needed.</p><p><strong>Patients and methods: </strong>In this retrospective observational analysis, medical device reports (MDRs) related to ReActiv8 were extracted from the FDA Manufacturer and User Facility Device Experience (MAUDE) database 6/17/2021-12/31/2025 (<i>n</i> = 341). Narrative reports were categorized into procedure-related (e.g. infection, hematoma/seroma, etc.), device-related (e.g. migration, lead damage, hardware malfunction, etc.), or patient-related (e.g. pocket pain, unwanted stimulation) complications after exclusion of duplicate or miscoded events.</p><p><strong>Results: </strong>There were 331 unique MDRs describing 344 reported events. Device-related events represented the largest proportion (<i>n</i> = 174, 50.6%), followed by patient-related (<i>n</i> = 109, 31.7%) and procedure-related events (<i>n</i> = 61, 17.7%). Surgical technique-related factors were reported as a possible contributing factor in 12.69% (<i>n</i> = 42) MDRs. Reported management included revision in 195 (58.91%) and explantation in 129 (38.97%).</p><p><strong>Conclusions: </strong>This characterization of ReActiv8-associated adverse events may help identify areas relevant to patient counseling, surgical technique, and future device optimization; however, these data cannot be used to estimate complication incidence or overall device safety.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibromyalgia beyond pain: a multisystemic dysregulation framework.","authors":"Mayte Serrat, Sergi Estanyol, David Cifre, Andrea Lizama-Lefno, Felipe Araya-Quintanilla, Ruben Nieto, Carlos Suso-Ribera, Miriam Almirall","doi":"10.1080/17581869.2026.2734039","DOIUrl":"https://doi.org/10.1080/17581869.2026.2734039","url":null,"abstract":"<p><p>Fibromyalgia (FM) is a prevalent and highly complex disease associated with a substantial reduction in quality of life and functional capacity, as well as significant use of healthcare resources. It is characterized by widespread pain, fatigue, sleep disturbances, and cognitive symptoms, among other manifestations. The heterogeneity of this symptomatology challenges traditional linear clinical models focused on the identification of overt structural damage. Based on a critical review of the contemporary literature, we argue that FM may represent the clinical expression of chronic dysregulation across multiple interacting physiological systems. Within this perspective, the peripheral nervous, central nervous, endocrine, and immune systems may influence central processes involved in nociceptive amplification, potentially contributing to the persistence of nociplastic pain states and the emergence of nonpain symptoms such as fatigue and cognitive dysfunction. Rather than replacing existing models, this perspective aims to expand them into a broader, nonreductionist framework that emphasizes systemic interactions and the loss of adaptive physiological coordination. Evidence was identified through PubMed/MEDLINE, Scopus, and Web of Science (2000-2026).</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromuscular electrical stimulation for pre- and post-knee replacement surgery: a qualitative study.","authors":"Nazmul Hussain, Dinesh Samuel, Gillian Lake-Thompson, Kai Yang","doi":"10.1080/17581869.2026.2734043","DOIUrl":"https://doi.org/10.1080/17581869.2026.2734043","url":null,"abstract":"<p><p>Total knee replacement effectively relieves pain and restores function in end-stage osteoarthritis, but rehabilitation is essential to optimize outcomes. Postoperative pain, quadriceps weakness, and limited mobility can restrict participation in conventional exercises. Neuromuscular electrical stimulation (NMES) may support muscle activation when voluntary exercise is difficult, yet its use in practice remains limited. This qualitative study explored perspectives of patients and healthcare professionals on NMES use in pre- and postoperative knee rehabilitation. Twelve participants, including seven patients with knee osteoarthritis and five clinicians, were interviewed using semi-structured interviews. Data were analyzed using reflexive thematic analysis. Participants reported benefits, including improved pain management and enhanced muscle activation, particularly when exercise was not feasible. Barriers included limited familiarity, device complexity and usability, cost, availability, and integration challenges within routine care. Our findings highlight the need for improved device design, better clinical training, and greater awareness. User-informed development may improve alignment with clinical needs and patient preferences in knee rehabilitation. These insights suggest that addressing educational gaps and simplifying device interfaces could enhance clinician confidence and patient engagement. Wider implementation may improve recovery experiences and functional outcomes following knee replacement surgery while supporting more equitable and efficient healthcare by enabling home-based rehabilitation.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of candidate predictors for chiropractic treatment outcome of spinal pain using a machine learning framework for small datasets.","authors":"Michael L Meier, Brigitte Wirth, Martina Wehrli, Valentin Hollenstein, Torsten Bergander, Petra Schweinhardt","doi":"10.1080/17581869.2026.2718881","DOIUrl":"https://doi.org/10.1080/17581869.2026.2718881","url":null,"abstract":"<p><strong>Objectives: </strong>To develop a machine learning (ML) approach to explore self-reported factors predictive for recovery in a small set of spinal pain patients.</p><p><strong>Methods: </strong>In this prospective cohort study, patients (<i>N</i> = 96; mean age = 44.5 ± 16.5 years; 53 female) completed an extensive questionnaire at baseline and after 1 and 3 months. Prediction targets were defined as binary outcomes (recovery/non-recovery) based on improvement at 3 months for pain intensity, disability, quality of life, and Patient Global Impression of Change. The ML-approach included three steps: selection of candidate baseline features (SHapley Additive exPlanations, SHAP); predictor validation (Leave-One-Out Cross-Validation, LOOCV) and permutation testing; testing for the ability to generalize.</p><p><strong>Results: </strong>Area under the curve (AUC) values were 0.93-0.99 in LOOCV and 0.62-0.90 in ensemble cross-validation (CV). SHAP analyses revealed higher recovery odds with positive treatment expectations and higher self-efficacy, younger age, lower body mass index, and fewer comorbidities. Psychological dysfunction generally hindered recovery.</p><p><strong>Conclusions: </strong>This explorative study suggests that the current ML framework may identify candidate predictors of chiropractic treatment outcome in spinal pain from a small but phenotypically rich dataset. Given the performance drop between LOOCV and ensemble CV, current findings are hypothesis-generating. Prospective replication in adequately powered cohorts is necessary.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of positive and negative peer modelling versus neutral social interaction before spinal manipulative therapy in adults with chronic non-specific low back pain: protocol for a three-arm randomized controlled trial.","authors":"Kamil Zaworski, Joanna Baj-Korpak, Anna Kręgiel-Rosiak, Andżelika Nazarewicz, Ewa Plażuk, Luana Colloca, Dave Newell, Chad Cook, Giacomo Rossettini","doi":"10.1080/17581869.2026.2731962","DOIUrl":"10.1080/17581869.2026.2731962","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic nonspecific low back pain (CNSLBP) is a leading cause of disability worldwide. Responses to spinal manipulative therapy (SMT) may be influenced by treatment expectations, which can be shaped through observational learning.</p><p><strong>Objectives: </strong>To compare current pain intensity 60 min after lumbar SMT among positive peer-modeling, neutral social-interaction, and negative peer-modeling conditions in individuals with CNSLBP.</p><p><strong>Methods/design: </strong>This single-center, three-arm randomized controlled trial will allocate participants in a 1:1:1 ratio to positive peer modeling, neutral social interaction, or negative peer modeling before receiving the standardized lumbar high-velocity low-amplitude SMT. Assessments will occur at baseline (T0a), immediately after the simulated-patient interaction and before SMT (T0b), 60 min after SMT (T1), and 24 h after SMT (T2). The primary outcome and time point will be current pain intensity measured with the 11-point Numerical Pain Rating Scale (NPRS-11) at T1. Secondary outcomes will include pain at T2, stress, kinesiophobia, disability, pressure pain threshold, tissue temperature, lumbar range of motion, expectation fulfillment, and treatment satisfaction. Empathy and inflammatory biomarkers will be evaluated as exploratory outcomes.</p><p><strong>Discussion: </strong>The trial will analyze whether the three simulated-patient conditions produce different short-term responses to identical SMT, without determining the effect of simulated-patient exposure compared with no exposure.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT07507604.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-17"},"PeriodicalIF":1.7,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically guided relaxation techniques in children undergoing medical procedures: a literature review.","authors":"Brinna Desai, Nita Kohli","doi":"10.1080/17581869.2026.2727568","DOIUrl":"https://doi.org/10.1080/17581869.2026.2727568","url":null,"abstract":"<p><p>Medical procedures can often be a source of distress and pain for children, which have been linked with worse clinical outcomes and additional concerns regarding treatment. Guided relaxation techniques have been shown to decrease feelings of anxiety surrounding medical procedures and improve health outcomes. The purpose of this review is to analyze studies involving the potential therapeutic effects of guided relaxation techniques, including guided imagery, clinical hypnosis, progressive muscle relaxation, and deep breathing techniques on children undergoing various procedures, including venipunctures, immunizations, and surgeries. The goal of this manuscript is to review current research and determine the need for future studies on the use of guided relaxation techniques as a standard of care in improving perioperative pain management in children.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fear of death increases nocebo-prone behavior in people with headaches during covid-19. A longitudinal observational survey.","authors":"Christina Deligianni, Eustathia Mitropoulou, Elina Kasioti, Savvas Christofilos, Georgios Karagiorgis, Charalambos Papageorgiou, Sofia Vassilopoulou, Petros P Sfikakis, Dimos-Dimitrios Mitsikostas","doi":"10.1080/17581869.2026.2726330","DOIUrl":"https://doi.org/10.1080/17581869.2026.2726330","url":null,"abstract":"<p><strong>Background: </strong>The nocebo effect greatly affects pain management. We investigated the nocebo-prone behavior in people with headaches during and after the COVID-19 pandemic, for which there is clear evidence that the nocebo effect increased.</p><p><strong>Methods: </strong>Individuals with headaches completed a series of questionnaires, including the Q-No, MIDAS, HIT-6, fear of death because of COVID-19 (a questionnaire including levels from 0 = no fear, to 3 = intense fear of death), and Hamilton Anxiety and Depression Rating Scale, over three consecutive periods. Period A was characterized by prolonged lockdowns, period B by strict pandemic regulations, and period C by the lifting of containment measures.</p><p><strong>Results: </strong>212 participants, 151 (71.2%) completed assessments across all three periods and were included. Nocebo-prone behavior (Q-No score ≥ 15) was detected in 16.6%, 14% and 9% of 151 participants in Period A, B and C, respectively (<i>p</i> < 0.05). Fear of death due to COVID-19 was recorded by 27.8%, 23.2% and 15.2%. Nocebo-prone behavior was independently associated with fear of death, anxiety symptoms, monthly headache days and HIT-6 score. .</p><p><strong>Conclusion: </strong>Nocebo-prone behavior in individuals with headache appears to be dynamic and associated with psychological and clinical burden. Targeted, personalized interventions addressing fear, anxiety, and headache burden may mitigate nocebo effects and optimize headache management.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided dextrose prolotherapy on regeneration of knee structures, pain, and function of a patient with patellofemoral pain syndrome - a case report.","authors":"Khristian Ralpheo A Furigay, Rochelle Angelica A Saratan, Melecio M Pena","doi":"10.1080/17581869.2026.2723916","DOIUrl":"https://doi.org/10.1080/17581869.2026.2723916","url":null,"abstract":"<p><p>Patellofemoral pain syndrome is one of the primary causes of anterior knee pain in young, physically active individuals. It usually presents with generalized anterior knee pain which is aggravated by weight-bearing activities. This is primarily managed conservatively through anti-inflammatory medications and physical therapy exercises. We discuss a case of a twenty-seven-year-old male presenting with right anterior knee pain. Assessment of knee structures, pain, and function were performed using the following research instruments, namely, musculoskeletal ultrasound, anterior knee pain scale (AKPS), and star excursion balance test (SEBT), respectively. 1 mL of 25% dextrose prolotherapy was introduced to the medial patellofemoral ligament, proximal patellar tendon, medial collateral ligament, anterior and posterior of the medial meniscus while 10 mL of 25% dextrose prolotherapy was introduced to the suprapatellar recess of the right knee for a total of 6 sessions. He was given an exercise program to allow for eventual return to sport. After which, improvement was noted in the different knee structures, most significantly on the lateral patellar tendon displacement, medial meniscus, and medial collateral ligament, AKPS scores and SEBT scores.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}