Pain managementPub Date : 2025-06-01Epub Date: 2025-05-16DOI: 10.1080/17581869.2025.2487406
Robert Croop, Peter J Goadsby, David A Stock, Charles M Conway, Micaela Forshaw, Elyse G Stock, Richard B Lipton
{"title":"Rimegepant orally disintegrating tablet for acute treatment of migraine: a plain language summary of a clinical study.","authors":"Robert Croop, Peter J Goadsby, David A Stock, Charles M Conway, Micaela Forshaw, Elyse G Stock, Richard B Lipton","doi":"10.1080/17581869.2025.2487406","DOIUrl":"10.1080/17581869.2025.2487406","url":null,"abstract":"","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"301-309"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case series of CT-fusion and real-time US-guidance in percutaneous RF thermocoagulation for trigeminal rhizotomy.","authors":"Chia-Hong Guo, Yung-Chi Hsu, Wei-Chen Liao, Hao-Lun Kao, Wei-Chou Chang, Yi-Chih Hsu","doi":"10.1080/17581869.2025.2508683","DOIUrl":"10.1080/17581869.2025.2508683","url":null,"abstract":"<p><p>This case series evaluates the feasibility, safety, and efficacy of real-time computed tomography fusion with ultrasound guidance (CTF-USG) in percutaneous radiofrequency thermocoagulation (RFT) for trigeminal rhizotomy. Traditional imaging modalities such as CT and fluoroscopy lack real-time visualization, increasing the risk of vascular injury and reducing procedural precision. The CTF-USG technique integrates CT imaging with real-time ultrasound via electromagnetic tracking, enabling accurate needle navigation and anatomical confirmation. Six patients with refractory trigeminal neuralgia affecting the V2 or V3 divisions underwent RFT guided by CTF-USG. All procedures achieved first-attempt needle placement success with no immediate complications. Postoperative assessments demonstrated significant reductions in pain scores at one and three months. The real-time imaging capability facilitated avoidance of critical structures, enhanced procedural safety. In conclusion, CTF-USG offers real-time imaging superior to C-arm fluoroscopy or standard CT, reducing complications and improving procedural accuracy. Primary technique efficacy was 100%. These advantages support its adoption in treating refractory trigeminal neuralgia.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"317-323"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-06-01Epub Date: 2025-05-14DOI: 10.1080/17581869.2025.2501521
Peter D Vu, Salahadin Abdi
{"title":"Post-acute sequelae SARS-CoV-2 infection and neuropathic pain: a narrative review of the literature and future directions.","authors":"Peter D Vu, Salahadin Abdi","doi":"10.1080/17581869.2025.2501521","DOIUrl":"10.1080/17581869.2025.2501521","url":null,"abstract":"<p><strong>Purpose of review: </strong>Neuropathic pain is a recognized and debilitating symptom of SARS-CoV-2 infection across acute, post-acute, and long-COVID phases. Initially emerging as acute or subacute symptoms, these neuropathic manifestations can evolve into chronic conditions, with approximately 10% of all SARS-CoV-2 cases (estimated 65 million individuals globally) developing post-acute SARS-CoV-2 (PASC) neuropathic sequalae. Given the limited literature specifically addressing neuropathic pain related to PASC, a deeper understanding is needed to improve management and reduce patient burden.</p><p><strong>Recent findings: </strong>PASC symptoms are associated with disease severity, elevated body mass indexes, preexisting psychological conditions, and addiction history. Sex differences appear to influence prevalence, and the multisystem nature of PASC complicates symptom presentation, with mood disorders, fatigue, and cognitive dysfunction contributing to altered pain perception. Proposed mechanisms include immune dysregulation, persistent viral protein effects, and neuroanatomical changes. Management typically involves a multimodal approach.</p><p><strong>Summary: </strong>This review examines SARS-CoV-2 neuropathic pain across the illness trajectory, examining its pathophysiology, prevalence, and treatment. It highlights the potential for subacute neuropathic symptoms to become chronic and calls for future research to refine long-term management strategies and assess broader healthcare implications.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"333-343"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-06-01Epub Date: 2025-05-23DOI: 10.1080/17581869.2025.2507559
Komal Luthra, Melissa Schwartz, Darsha Krishnamurthi, Pranamya Suri, Scott Benkovic, Akhil Chhatre
{"title":"Baastrup's disease in a patient with multifactorial back pain: a case report.","authors":"Komal Luthra, Melissa Schwartz, Darsha Krishnamurthi, Pranamya Suri, Scott Benkovic, Akhil Chhatre","doi":"10.1080/17581869.2025.2507559","DOIUrl":"10.1080/17581869.2025.2507559","url":null,"abstract":"<p><p>Lower back pain is a common yet often misdiagnosed condition due to its multifactorial nature and presence of other underlying pathologies. Baastrup's disease is an underdiagnosed cause of lower back pain. We present a case of a 67-year-old female who initially presented with lower back pain and associated radiation to bilateral lower extremities. The patient's imaging revealed moderate spinal canal stenosis at L4-L5 due to grade 1 anterolisthesis, severe right L5-S1 neural foraminal stenosis, and a dorsal epidural cyst with interspinous bursitis possibly related to Baastrup's disease. The patient underwent L4-L5 interlaminar epidural steroid injection with cyst aspiration under fluoroscopic guidance and had temporary relief. Given the multifactorial nature of her pain, she subsequently underwent greater trochanter bursa steroid injections and bilateral L3-L5 medial branch blocks, resulting in significant pain relief. Our case demonstrates the multifactorial nature of lower back pain, where treatment of each underlying aspect, including identification of Baastrup's Disease with associated epidural cyst, resulted in pain relief. It also underscored the importance of considering the patient's history when using steroid injections in interventional procedures and determining when a patient is more appropriate for surgery.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"311-315"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-06-01Epub Date: 2025-05-26DOI: 10.1080/17581869.2025.2511464
Tianhong Cai, Rong Zhang, Kai Chen, Ting Deng, Tenghui Zhan
{"title":"Safety and efficacy of intra-arterial lidocaine administration for pain control in uterine artery embolization for cesarean scar pregnancy.","authors":"Tianhong Cai, Rong Zhang, Kai Chen, Ting Deng, Tenghui Zhan","doi":"10.1080/17581869.2025.2511464","DOIUrl":"10.1080/17581869.2025.2511464","url":null,"abstract":"<p><strong>Background: </strong>Uterine artery embolization (UAE) for cesarean scar pregnancy (CSP) can cause significant pain.</p><p><strong>Objectives: </strong>To evaluate safety and efficacy of intra-arterial lidocaine during UAE for CSP.</p><p><strong>Methods: </strong>Retrospective study of 255 CSP patients: Control Group (184) without lidocaine; Study Group I (39) with unilateral lidocaine; Study Group II (32) with bilateral lidocaine. Outcomes included VAS pain scores and morphine usage.</p><p><strong>Results: </strong>Early postoperative VAS scores (0-2 hours) were significantly lower in study groups (<i>p</i> < 0.001). No differences in later VAS scores (4-24 hours), maximal VAS scores, morphine dosage, or safety indicators.</p><p><strong>Conclusion: </strong>Intra-arterial lidocaine during UAE for CSP provides effective analgesia immediately post-procedure but only for the first 2-4 hours, without reducing overall opioid requirements.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"325-332"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-06-01Epub Date: 2025-05-22DOI: 10.1080/17581869.2025.2510191
Zhengqin Shi, Hong Sun, Junlei Wu, Yude Jin, Sujie Cao, Jianli Cai
{"title":"Chinese acupoint therapies in cancer pain management: research advances and future perspectives.","authors":"Zhengqin Shi, Hong Sun, Junlei Wu, Yude Jin, Sujie Cao, Jianli Cai","doi":"10.1080/17581869.2025.2510191","DOIUrl":"10.1080/17581869.2025.2510191","url":null,"abstract":"<p><p>Cancer pain management (CPM) is crucial in oncology care, with current approaches including pharmacotherapy, radiotherapy, chemotherapy, nerve blocks, and psychological support. However, long-term drug use risks adverse effects and addiction, while physiotherapies often lack sustained efficacy. Therefore, identifying safer adjuvant analgesic therapies has become an urgent issue. Traditional Chinese Medicine (TCM) acupoint therapies (acupuncture, moxibustion, and acupoint injection) offer safer adjuvant analgesia with growing clinical validation. This narrative review aims to introduce the research progress of acupoint therapy in alleviating cancer pain and the role of emerging technologies in advancing acupoint therapy. All literature selections were sourced exclusively from PubMed and CNKI databases. First, we briefly introduce the mechanisms of cancer pain, outline relevant evaluation methods, and summarize the limitations of existing CPM strategies. Additionally, we discuss the therapeutic effects, underlying mechanisms, and potential improvements of acupoint therapies in CPM. Notably, recent advancements in information technology, artificial intelligence, and materials science, along with the development of noninvasive stimulation methods and innovative devices, have significantly advanced the understanding of acupoint treatment mechanisms and expanded their clinical applications. Finally, we highlight the challenges and future directions for TCM acupoint therapies. This study provides clinical insights and recommendations for CPM.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"345-358"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-05-01Epub Date: 2025-05-08DOI: 10.1080/17581869.2025.2502311
Fanny Jogna, Adriana Graenicher A, Quentin Rey-Millet, Alexandra Groz, Jehanne De Grasset, Fabiola Stollar, Matteo Coen, Anna Faivre
{"title":"Pharmacological and non-pharmacological approaches to temporomandibular disorder chronic pain: a narrative review.","authors":"Fanny Jogna, Adriana Graenicher A, Quentin Rey-Millet, Alexandra Groz, Jehanne De Grasset, Fabiola Stollar, Matteo Coen, Anna Faivre","doi":"10.1080/17581869.2025.2502311","DOIUrl":"10.1080/17581869.2025.2502311","url":null,"abstract":"<p><p>Temporomandibular disorders (TMD) involve the temporomandibular joint and related structures, causing chronic pain, impaired jaw function, and reduced quality of life. TMD has multifactorial origins, including mechanical, neuromuscular, and inflammatory factors. Chronic TMD pain is difficult to manage due to its complex pathophysiology and the limited long-term effectiveness of existing treatments. A combination of pharmacological and non-pharmacological strategies is essential for optimal pain management. This narrative review provides an integrative overview of current treatments for TMD-associated chronic pain. Pharmacological options discussed include analgesics, muscle relaxants, antidepressants, anticonvulsants, and botulinum toxin injections. Non-pharmacological strategies include physical therapy, cognitive-behavioral therapy, acupuncture, and lifestyle modifications. A comprehensive literature search was conducted using PubMed, Embase.com, Cochrane, and Evidence Alerts databases through October 2024. We focused on original research articles, randomized controlled trials, narrative and systematic reviews, and meta-analyses. Effective management of chronic TMD pain requires a multidisciplinary approach tailored to individual needs. Evidence supports the integration of physical and psychological therapies into treatment plans. Future research should aim to develop targeted interventions that address underlying mechanisms of TMD pain and evaluate the long-term outcomes of noninvasive therapies.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"285-296"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-05-01Epub Date: 2025-04-28DOI: 10.1080/17581869.2025.2494495
Mathieos Belayneh, Samar Hejazi, Bruno Gagnon, Philippa Hawley
{"title":"Methadone to treat chemotherapy-induced peripheral neuropathy (METACIN): study protocol.","authors":"Mathieos Belayneh, Samar Hejazi, Bruno Gagnon, Philippa Hawley","doi":"10.1080/17581869.2025.2494495","DOIUrl":"10.1080/17581869.2025.2494495","url":null,"abstract":"<p><strong>Rationale: </strong>Chronic chemotherapy-induced peripheral neuropathy (CIPN) affects 70% of cancer patients, causing neuropathic pain. Duloxetine is the most recommended treatment for CIPN per most guidelines. However, Methadone, an alternative and effective treatment for refractory neuropathic cancer pain has been under-recognized and under-studied in patients with CIPN.</p><p><strong>Participants: </strong>Adult patients with cancer and life expectancy greater than 12 weeks who have >grade 1 CIPN based on National Cancer Institute Common Toxicity Criteria for Adverse Events version 5.0 grading scale lasting ≥3 months beyond chemotherapy completion.</p><p><strong>Intervention: </strong>A triple-blind, double-dummy randomized controlled trial, participants randomized to either methadone or duloxetine, followed weekly over 5 weeks with dose titration.</p><p><strong>Outcomes: </strong>Primary outcome is the efficacy of methadone versus duloxetine in reducing average pain intensity from baseline to study end. Secondary outcomes include improvements in functional and quality-of-life interference. Exploratory outcomes include proportion of participants achieving ≥30% or ≥50% pain reduction, patient-reported global impression of change, incidence of adverse events, and methadone dose escalation over a 24-week follow up period.</p><p><strong>Anticipated impact: </strong>This study will determine if methadone is a viable treatment for CIPN; a very common, distressing, and debilitating condition that otherwise has limited treatment options.</p><p><strong>Clinical trial registration: </strong>www.clinicaltrials.gov identifier is NCT05786599.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"235-243"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain managementPub Date : 2025-05-01Epub Date: 2025-05-20DOI: 10.1080/17581869.2025.2508680
Masataka Umeda, Youngdeok Kim
{"title":"The role of anxiety in the association between physical pain and social pain sensitivity in young adults.","authors":"Masataka Umeda, Youngdeok Kim","doi":"10.1080/17581869.2025.2508680","DOIUrl":"10.1080/17581869.2025.2508680","url":null,"abstract":"<p><strong>Background: </strong>We experience physical pain and social pain. While rejection sensitivity measures, such as Brief Fear of Negative Evaluation Scale (BFNES), were previously used to evaluate social pain sensitivity, Social Pain Questionnaire (SPQ) has been developed to specifically evaluate social pain sensitivity. Although physical pain and social pain seem quite distinct from each other, research shows a close link between them. However, the association between physical pain sensitivity and SPQ remains unclear. This study examined the association of SPQ with BFNES and Pain Sensitivity Questionnaire (PSQ), an instrument to evaluate physical pain sensitivity, and involvement of anxiety in the association between physical pain and social pain sensitivity.</p><p><strong>Methods: </strong>One-hundred forty young adults participated in this cross-sectional survey study and completed the general information questionnaire, PSQ, BFNES, SPQ, and Trait Anxiety Inventory (TAI). Data were analyzed using correlation and partial correlation analyses.</p><p><strong>Results: </strong>SPQ was associated with both PSQ and BFNES, while TAI was associated with PSQ, BFNES, and SPQ. The association between PSQ and BFNES remained significant after controlling TAI, but the association between PSQ and SPQ disappeared.</p><p><strong>Conclusion: </strong>The results demonstrate convergent validity of SPQ in pain. Anxiety may explain the association between physical pain and social pain sensitivity.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"259-264"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}