Opioid-free anaesthesia as a valuable alternative to opioid-based practices: evidence and future challenges.

IF 1.5 Q4 CLINICAL NEUROLOGY
Pain management Pub Date : 2025-10-01 Epub Date: 2025-08-06 DOI:10.1080/17581869.2025.2542719
Yann Gricourt, Philippe Cuvillon, Patrice Forget
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引用次数: 0

Abstract

Opioid-Free-Anesthesia (OFA) offers a valuable alternative model that challenges traditional opioid-based anesthesia practices. Recent studies have tempered expectations regarding the capacity of OFA techniques to improve quality of postoperative pain management and early recovery, in contrast with the clearly decreased risk of postoperative nausea and vomiting. Essentially based on regional anesthesia, non-opioid adjuvants and multimodal analgesia, OFA should be better viewed as a menu rather than a recipe, guided by surgical invasiveness, patient background, expected postoperative pain, and the practitioner's expertise. Potential concerns of OFA, including bradycardia and hypotension, are manageable with proper training and adapted dosing. Further multicentre trials and non-inferiority studies are needed to better define OFA's impact on patient-reported outcome and experiences measures in perioperative care.

无阿片类麻醉作为阿片类药物实践的宝贵替代方案:证据和未来挑战。
无阿片类药物麻醉(OFA)提供了一个有价值的替代模式,挑战传统的阿片类药物麻醉实践。最近的研究对OFA技术提高术后疼痛管理和早期恢复质量的能力的期望有所降低,相比之下,术后恶心和呕吐的风险明显降低。OFA主要基于区域麻醉、非阿片类辅助药物和多模式镇痛,应更好地将其视为一份菜单,而不是处方,由手术侵入性、患者背景、预期的术后疼痛和医生的专业知识指导。OFA的潜在问题,包括心动过缓和低血压,通过适当的训练和适当的剂量是可以控制的。需要进一步的多中心试验和非劣效性研究来更好地确定OFA对围手术期护理中患者报告的结果和经历测量的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pain management
Pain management CLINICAL NEUROLOGY-
CiteScore
2.90
自引率
5.90%
发文量
62
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