Pediatric Investigation最新文献_第7页

Tubulointerstitial nephritis and uveitis syndrome post-COVID-19. COVID-19后的肾小管间质性肾炎和葡萄膜炎综合征。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-02-01 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12362

Maria Cristina Maggio, Filippo Collura, Maria Michela D'Alessandro, Barbara Gramaglia, Giovanni Corsello

引用次数: 0

Better design leads to better results - Importance of virological outcome design in clinical trials for antiviral treatment of coronavirus disease 2019. 更好的设计带来更好的结果 - 冠状病毒疾病抗病毒治疗临床试验中病毒学结果设计的重要性 2019.

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-01-09 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12363

Getu Zhaori, Lu Lu, Chunyan Liu, Shujing Han, Yongli Guo

引用次数: 0

Sifrim-Hitz-Weiss/CHD4-related syndrome: A new case report. 西福林-Hitz-魏斯/CHD4相关综合征：新病例报告

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-01-04 eCollection Date: 2023-06-01 DOI: 10.1002/ped4.12357

Beibei Zhang, Ming Cheng, Lijun Fan, Chunxiu Gong

引用次数: 0

Spontaneous regression of tumor in a girl with optic pathway glioma with diencephalic syndrome. 一名患有视通路胶质瘤并伴有间脑综合征的女孩肿瘤自发消退。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-01-03 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12356

Rutao Luo, Tianlei Zhang, Wei Yang, Yuanqi Ji, Hailang Sun, Dapeng Li, Ming Ge

引用次数: 0

Changes in utilization of online pediatric educational resources during the coronavirus disease 2019 pandemic. 2019 年冠状病毒疾病大流行期间在线儿科教育资源利用率的变化。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2023-01-03 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12360

Dennis Daniel, Anna Krotinger, Traci Wolbrink

引用次数: 0

Long-acting growth hormone in 2022. 2022年长效生长激素。

IF 2.2 4区医学

Pediatric Investigation Pub Date : 2023-01-03 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12358

Margaret Steiner, Jacklyn Frank, Paul Saenger

引用次数: 3

Phenomapping approach to interpreting coronary dimensions in febrile children. 解释发热儿童冠状动脉尺寸的表象图法。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-12-15 eCollection Date: 2022-12-01 DOI: 10.1002/ped4.12361

Haoxun Tang, Xin Guo, Xiaolu Nie, Lin Zheng, Gang Liu, Wilfred Hing-Sang Wong, Yiu-Fai Cheung

{"title":"Phenomapping approach to interpreting coronary dimensions in febrile children.","authors":"Haoxun Tang, Xin Guo, Xiaolu Nie, Lin Zheng, Gang Liu, Wilfred Hing-Sang Wong, Yiu-Fai Cheung","doi":"10.1002/ped4.12361","DOIUrl":"10.1002/ped4.12361","url":null,"abstract":"Importance: Coronary artery dilation may occur in febrile children with and without Kawasaki disease (KD).Objective: We explored the application of unsupervised learning algorithms in the detection of novel patterns of coronary artery phenotypes in febrile children with and without KD.Methods: A total of 239 febrile children (59 non-KD and 180 KD patients), were recruited. Unsupervised hierarchical clustering analysis of phenotypic data including age, hemoglobin, white cell count, platelet count, C-reactive protein, erythrocyte sedimentation rate, albumin, alanine aminotransferase, aspartate aminotransferase, and coronary artery z scores were performed.Results: Using a cutoff z score of 2.5, the specificity was 98.3% and the sensitivity was 22.1% for differentiating non-KD from KD patients. Clustering analysis identified three phenogroups that differed in a clinical, laboratory, and echocardiographic parameters. Compared with phenogroup I, phenogroup III had the highest prevalence of KD (91%), worse inflammatory markers, more deranged liver function, higher coronary artery z scores, and lower hematocrit and albumin levels. Abnormal blood parameters in febrile children with z scores of coronary artery segments <0.5 and 0.5-1.5 was associated with increased risks of having KD to 8.7 (P = 0.003) and 4.4 (P = 0.002), respectively.Interpretation: Phenomapping of febrile children with and without KD identified useful laboratory parameters that aid the diagnosis of KD in febrile children with relatively normal-sized coronary arteries.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"6 4","pages":"233-240"},"PeriodicalIF":1.9,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/51/3b/PED4-6-233.PMC9789931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcatheter pulmonary valve replacement in congenital heart diseases. 先天性心脏病经导管肺动脉瓣置换术。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-12-05 eCollection Date: 2022-12-01 DOI: 10.1002/ped4.12359

Adolphus Kai-Tung Chau

{"title":"Transcatheter pulmonary valve replacement in congenital heart diseases.","authors":"Adolphus Kai-Tung Chau","doi":"10.1002/ped4.12359","DOIUrl":"10.1002/ped4.12359","url":null,"abstract":"Surgical repair of a variety of congenital heart diseases involves repair of the right ventricular outflow tract (RVOT) with valved or non-valved conduit to connect the right ventricle (RV) to the pulmonary artery (PA) or just patch enlargement of the native RVOT. With time, this RV-PA conduit will degenerate with deterioration of function, either causing pulmonary stenosis or pulmonary regurgitation. This RVOT dysfunction may result in RV dilation, RV dysfunction, and eventual RV failure and arrhythmias. Multiple surgical pulmonary valve replacement (PVR) is often required throughout the patient's lifetime. Patients are subjected to increased risks with each additional cardiac operation. Transcatheter PVR (TPVR) has been developed over the past two decades as a valuable non-surgical alternative to restore the RVOT and RV function, and hence reduce patients' lifetime risks related to surgery. This article will discuss the long-term results of TPVR which are demonstrated to be comparable to surgical results and the latest development of large pulmonary valves which will allow TPVR to be performed on native or larger RVOT.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"6 4","pages":"280-290"},"PeriodicalIF":1.9,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/10/PED4-6-280.PMC9789934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10821627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography of the pulmonary arteries in children with congenital heart diseases: A systematic review. 先天性心脏病患儿肺动脉的光学相干断层扫描：系统综述。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-11-30 eCollection Date: 2022-12-01 DOI: 10.1002/ped4.12353

Ling Sun, Qiuping Jiang, Yumei Xie, Shushui Wang, Zhiwei Zhang

{"title":"Optical coherence tomography of the pulmonary arteries in children with congenital heart diseases: A systematic review.","authors":"Ling Sun, Qiuping Jiang, Yumei Xie, Shushui Wang, Zhiwei Zhang","doi":"10.1002/ped4.12353","DOIUrl":"10.1002/ped4.12353","url":null,"abstract":"Importance: Optical coherence tomography (OCT) is a high-resolution intravascular imaging tool and has shown promise for providing real-time quantitative and qualitative descriptions of pulmonary vascular structures in vivo in adult pulmonary hypertension (PH), while not popular in pediatric patients with congenital heart diseases (CHD).Objective: The aim of this review is to summarize all the available evidence on the use of OCT for imaging pulmonary vascular remodeling in pediatric patients.Methods: We conducted the systematic literature resources (Cochran Library database, Medline via PubMed, EMBASE, and Web of Knowledge) from January 2010 to December 2021 and the search terms were \"PH\", \"child\", \"children\", \"pediatric\", \"OCT\", \"CHD\", \"pulmonary vessels\", \"pulmonary artery wall\". Studies in which OCT was used to image the pulmonary vessels in pediatric patients with CHD were considered for inclusion.Results: Five studies met the inclusion criteria. These five papers discussed the study of OCT in the pulmonary vasculature of different types of CHD, including common simple CHD, complex cyanotic CHD, and Williams-Beuren syndrome. In biventricular anatomy, pulmonary vascular remodeling was primarily reflected by pulmonary intima thickening from two-dimensional OCT. In single-ventricle anatomy, due to the state of hypoxia, the morphology of pulmonary vessels was indirectly reflected by the number and shape of nourishing vessels from three-dimensional OCT.Interpretation: OCT may be an adequate imaging procedure for the demonstration of pulmonary vascular structures and provide additional information in pediatric patients.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"6 4","pages":"264-270"},"PeriodicalIF":1.9,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/4a/PED4-6-264.PMC9789933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bath-plug technique for the endoscopic management of cerebrospinal fluid leaks in children. 用于内窥镜治疗儿童脑脊液漏的浴塞技术。

IF 1.9 4区医学

Pediatric Investigation Pub Date : 2022-11-22 eCollection Date: 2023-03-01 DOI: 10.1002/ped4.12354

Xiaojian Yang, Lixing Tang, Pengpeng Wang, Ming Ge, Wei Zhang, Xiao Xiao, Yang Han, Wentong Ge

{"title":"Bath-plug technique for the endoscopic management of cerebrospinal fluid leaks in children.","authors":"Xiaojian Yang, Lixing Tang, Pengpeng Wang, Ming Ge, Wei Zhang, Xiao Xiao, Yang Han, Wentong Ge","doi":"10.1002/ped4.12354","DOIUrl":"10.1002/ped4.12354","url":null,"abstract":"Importance: The safety and efficacy of the bath-plug technique for the closure of cerebrospinal fluid (CSF) leaks in children remain unknown.Objective: We undertook this study to ascertain whether the bath-plug technique was safe and effective for the repair of CSF leaks.Methods: We retrospectively reviewed patients who underwent endoscopic repair of CSF leaks with the fat graft as a plug-in at Beijing Children's Hospital from March 2016 to May 2020. Demographic data, medical history, defect sites and sizes, interventions, and clinical outcomes were analyzed. One representative clinical case was additionally selected to highlight the procedure and the healing process.Results: A total of 18 pediatric patients were included in this study. The group was composed of 11 boys and seven girls, aged from 5 to 123 months. The etiologies included congenital CSF leaks (n = 9) and head trauma (n = 9). Among all patients, 12 fistulas (66.7%) were located at the cribriform plate area, two (11.1%) at the roof of the ethmoid sinuses, two (11.1%) in the sphenoid sinus, and two (11.1%) at the frontal sinus. The maximum diameters of fistulas ranged from 5 to 20 mm, with a median value of 8 mm. Encephaloceles were identified in 14 (77.8%) patients. No hydrocephalus was recognized. All CSF leaks were successfully repaired with a bath-plug technique. Follow-up ranged from 50 to 70 months. No surgical complications were encountered in any patient.Interpretation: Bath-plug technique is safe and reliable for the endoscopic management of CSF leaks in children. Meticulous peri-operative preparations are important for pediatric patients.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"23-28"},"PeriodicalIF":1.9,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/df/PED4-7-23.PMC10030683.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0