Pediatric Investigation最新文献

{"title":"Nirsevimab brings breakthrough in the prevention of respiratory syncytial virus infection in infants - Importance of design.","authors":"Getu Zhaori","doi":"10.1002/ped4.12377","DOIUrl":"10.1002/ped4.12377","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/14/PED4-7-144.PMC10262870.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new column in this journal - Forum on Clinical Investigation.","authors":"Getu Zhaori","doi":"10.1002/ped4.12378","DOIUrl":"10.1002/ped4.12378","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/58/PED4-7-147.PMC10262868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of activity and face masks on exhaled particles in children.","authors":"Peter P Moschovis, Jesiel Lombay, Jennifer Rooney, Sara R Schenkel, Dilpreet Singh, Shawheen J Rezaei, Nora Salo, Amanda Gong, Lael M Yonker, Jhill Shah, Douglas Hayden, Patricia L Hibberd, Philip Demokritou, T Bernard Kinane","doi":"10.1002/ped4.12376","DOIUrl":"10.1002/ped4.12376","url":null,"abstract":"<p><strong>Importance: </strong>Despite the high burden of respiratory infections among children, the production of exhaled particles during common activities and the efficacy of face masks in children have not been sufficiently studied.</p><p><strong>Objective: </strong>To determine the effect of type of activity and mask usage on exhaled particle production in children.</p><p><strong>Methods: </strong>Healthy children were asked to perform activities that ranged in intensity (breathing quietly, speaking, singing, coughing, and sneezing) while wearing no mask, a cloth mask, or a surgical mask. The concentration and size of exhaled particles were assessed during each activity.</p><p><strong>Results: </strong>Twenty-three children were enrolled in the study. Average exhaled particle concentration increased by intensity of activity, with the lowest particle concentration during tidal breathing (1.285 particles/cm³ [95% CI 0.943, 1.627]) and highest particle concentration during sneezing (5.183 particles/cm³ [95% CI 1.911, 8.455]). High-intensity activities were associated with an increase primarily in the respirable size (≤ 5 µm) particle fraction. Surgical and cloth masks were associated with lower average particle concentration compared to no mask (<i>P</i> = 0.026 for sneezing). Surgical masks outperformed cloth masks across all activities, especially within the respirable size fraction. In a multivariable linear regression model, we observed significant effect modification of activity by age and by mask type.</p><p><strong>Interpretation: </strong>Similar to adults, children produce exhaled particles that vary in size and concentration across a range of activities. Production of respirable size fraction particles (≤ 5 µm), the dominant mode of transmission of many respiratory viruses, increases significantly with coughing and sneezing and is most effectively reduced by wearing surgical face masks.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/26/5e/PED4-7-75.PMC10262878.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A great pediatrician and scholar devoting his whole life to pediatric infectious and digestive diseases—In memoriam of Professor Yongsui Dong","authors":"Xinglou Liu, S. Shu, S. Gong, Xiaoping Luo, F. Fang","doi":"10.1002/ped4.12373","DOIUrl":"https://doi.org/10.1002/ped4.12373","url":null,"abstract":"Professor Dong graduated from the Medical College of Fudan University (formerly Shanghai First Medical College) with excellent grades in 1956. Then he worked at Zhongnan Tongji Medical College (now Tongji Medical College of Huazhong University of Science and Technology) and its affiliated Wuhan Tongji Hospital. He soon became the backbone of the college and was responsible for establishing the Department of Pediatrics. With the aspiration of being “a good physician, a good teacher, and a good scholar”, Professor Dong strived to be progressive and comprehensive in clinical practice, teaching, and scientific research. He had devoted his whole life to safeguarding children’s health, developing pediatrics, and cultivating excellent pediatricians in China.","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78987688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective antimicrobial therapies of urinary tract infections among children in low- and middle-income countries: A systematic review.","authors":"Rifat Ara, Sarker Mohammad Nasrullah, Zarrin Tasnim, Sadia Afrin, Mohammad Delwer Hossain Hawlader, K M Saif-Ur-Rahman","doi":"10.1002/ped4.12375","DOIUrl":"10.1002/ped4.12375","url":null,"abstract":"<p><strong>Importance: </strong>Urinary tract infection (UTI) is one of the most common infections encountered in infancy and childhood. Despite the emerging problem of antibiotic resistance in recent years, the use of antibiotics for better management of UTIs is inevitable.</p><p><strong>Objective: </strong>This study aims to explore the efficacy and adverse effects of the available antimicrobial agents that are used in pediatric UTIs in low- and middle-income countries (LMICs).</p><p><strong>Methods: </strong>Five electronic databases were searched to identify relevant articles. Two reviewers independently performed screening, data extraction, and quality assessment of the available literature. Randomized controlled trials providing antimicrobial interventions in both male and female participants within the age range of 3 months to 17 years in LMICs were included.</p><p><strong>Results: </strong>Six randomized controlled trials from 13 LMICs were included in this review (four trials explored the efficacy). Due to high heterogeneity across the studies, a meta-analysis was not performed. Other than attrition and reporting bias, the risk of bias was moderate to high due to poor study designs. The differences in the efficacy and adverse events of different antimicrobials were not found to be statistically significant.</p><p><strong>Interpretation: </strong>This review indicates the necessity for additional clinical trials on children from LMICs with more significant sample numbers, adequate intervention periods, and study design.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/84/PED4-7-102.PMC10262900.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of the atopic dermatitis and infant skincare knowledge, attitude, and practice (ADISKAP 1.0) scale.","authors":"Xiaoyan Sun, Mutong Zhao, Qiong Wu, Jing Tian, Chunping Shen, Yuan Liang, Shan Wang, Lei Jiao, Yang Wang, Mingyi Liu, Lin Ma, Xiuhua Ma","doi":"10.1002/ped4.12374","DOIUrl":"10.1002/ped4.12374","url":null,"abstract":"<p><strong>Importance: </strong>Preserving skin health is crucial for atopic dermatitis control as well as for the thriving of children. However, a well-developed and validated tool that measures the knowledge, attitude, and practice of skin care is lacking.</p><p><strong>Objective: </strong>To develop and validate the atopic dermatitis and infant skincare knowledge, attitude, and practice (ADISKAP 1.0) scale that measures parental health literacy on atopic dermatitis and skin care.</p><p><strong>Methods: </strong>We conducted a review of the literature, a focus group (two dermatologists and 12 parents), and a panel discussion in order to generate the ADISKAP prototype. Two samples of parents with knowingly superior (dermatologists, <i>n</i> = 59) and inferior (general population, <i>n</i> = 395) knowledge traits participated in the validation of ADISKAP. Cronbach's alpha was reported as a measure of internal consistency, and the intraclass correlation coefficient (ICC) was calculated to assess the test-retest validity. The known-groups technique was used to evaluate construct validity.</p><p><strong>Results: </strong>The ADISKAP scale contained 17 items after content and face validity validation. After removing items that displayed poor test-retest reliability (<i>n</i> = 4) and construct validity (<i>n</i> = 3), 12 items were retained in the ADISKAP 1.0.</p><p><strong>Interpretation: </strong>ADISKAP 1.0 is a reliable and valid tool for assessing parental knowledge, attitude, and practice on infantile atopic dermatitis and skin care.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/76/PED4-7-153.PMC10509389.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the surgical stress in open and laparoscopic treatment of inguinal hernia in children.","authors":"Charikleia D Demiri, Christos Kaselas, Stavros Iliadis, Maria Tsopozidi, Ioannis Spyridakis","doi":"10.1002/ped4.12372","DOIUrl":"10.1002/ped4.12372","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/13/PED4-7-71.PMC10262887.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of <i>Haemophilus Influenzae</i> serotype a intracranial infections in older children.","authors":"Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza","doi":"10.1002/ped4.12369","DOIUrl":"10.1002/ped4.12369","url":null,"abstract":"<p><strong>Introduction: </strong><i>Haemophilus influenzae</i> (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.</p><p><strong>Case presentation: </strong>We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.</p><p><strong>Conclusion: </strong>Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/ef/PED4-7-132.PMC10262899.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital cutaneous mastocytosis mistaken for non-accidental injury.","authors":"Emma Porter, Cynthia Heffron, Lesley Ann Murphy, Cathal O'Connor","doi":"10.1002/ped4.12370","DOIUrl":"10.1002/ped4.12370","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/24/PED4-7-218.PMC10509383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to magnesium sulfate and adrenocorticotropic hormone combination therapy for infantile spasms with failed first-line treatments.","authors":"Qiuhong Wang, Wen He, Yangyang Wang, Liying Liu, Mengna Zhang, Xiaoyan Yang, Liping Zou","doi":"10.1002/ped4.12368","DOIUrl":"10.1002/ped4.12368","url":null,"abstract":"<p><strong>Importance: </strong>Infantile spasm (IS) is a kind of refractory epilepsy. The first-line treatments for IS are adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.</p><p><strong>Objective: </strong>This study aimed to evaluate the efficacy of magnesium sulfate and ACTH (MgSO₄+ACTH) combination therapy in patients with IS who failed first-line treatments.</p><p><strong>Methods: </strong>In this retrospective study, the clinical data of patients with IS who failed first-line treatments were collected in the Chinese PLA General Hospital. Patients received MgSO₄+ACTH combination therapy after first-line treatments failed. The course of treatments was 2 weeks. The therapeutic dose of ACTH and MgSO₄ was 2.5 U·kg^-1·d^-1 and 0.25 g·kg^-1·d^-1, respectively.</p><p><strong>Results: </strong>A total of 229 patients with IS who failed the first-line treatments were collected. At the end of the MgSO₄+ACTH combination treatment, the seizure-free rate was 48.5% (111/229), and the resolution of hypsarrhythmia on electroencephalogram (EEG) was 72.1% (165/229). About 21.4% (49/229) of patients showed side effects, including infectious diseases, hypokalemia, and diarrhea.</p><p><strong>Interpretation: </strong>For patients with IS who failed first-line treatments, in terms of the seizure-free rate and resolution of hypsarrhythmia on EEG, MgSO₄+ACTH combination therapy can be considered.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/81/PED4-7-29.PMC10030695.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}