Pediatric Investigation最新文献

{"title":"Instruction for Authors.","authors":"","doi":"10.1002/ped4.12371","DOIUrl":"https://doi.org/10.1002/ped4.12371","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/8a/PED4-7-63.PMC10030699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9174888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.","authors":"Qiaoyu Shi,&nbsp;Kemin Qi","doi":"10.1002/ped4.12367","DOIUrl":"10.1002/ped4.12367","url":null,"abstract":"<p><p>Most epidemiological and experimental studies have focused on maternal influences on offspring's health. The impact of maternal undernutrition, overnutrition, hypoxia, and stress is linked to adverse offspring outcomes across a range of systems including cardiometabolic, respiratory, endocrine, and reproduction among others. During the past decade, it has become evident that paternal environmental factors are also linked to the development of diseases in offspring. In this article, we aim to outline the current understanding of the impact of male health and environmental exposure on offspring development, health, and disease and explore the mechanisms underlying the paternal programming of offspring health. The available evidence suggests that poor paternal pre-conceptional nutrition and lifestyle, and advanced age can increase the risk of negative outcomes in offspring, via both direct (genetic/epigenetic) and indirect (maternal uterine environment) effects. Beginning at preconception, and during utero and the early life after birth, cells acquire an epigenetic memory of the early exposure which can be influential across the entire lifespan and program a child's health. Potentially not only mothers but also fathers should be advised that maintaining a healthy diet and lifestyle is important to improve offspring health as well as the parental health status. However, the evidence is mostly based on animal studies, and well-designed human studies are urgently needed to verify findings from animal data.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/11/PED4-7-111.PMC10262906.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel <i>SLC30A2</i> mutations in the pathogenesis of transient neonatal zinc deficiency.","authors":"Taichiro Muto, Yuriko Kawase, Kaori Aiba, Miyuki Okuma, Naoya Itsumura, Shuangyu Luo, Namino Ogawa, Tokuji Tsuji, Taiho Kambe","doi":"10.1002/ped4.12366","DOIUrl":"10.1002/ped4.12366","url":null,"abstract":"<p><strong>Importance: </strong>Transient neonatal zinc deficiency (TNZD) occurs in breastfed infants due to abnormally low breast milk zinc levels. Mutations in the solute carrier family 30 member 2 (<i>SLC30A2</i>) gene, which encodes the zinc transporter ZNT2, cause low zinc concentration in breast milk.</p><p><strong>Objective: </strong>This study aimed to provide further insights into TNZD pathophysiology.</p><p><strong>Methods: </strong><i>SLC30A2</i> sequencing was performed in three unrelated Japanese mothers, whose infants developed TNZD due to low-zinc milk consumption. The effects of the identified mutations were examined using cell-based assays and luciferase reporter analysis.</p><p><strong>Results: </strong>Novel <i>SLC30A2</i> mutations were identified in each mother. One harbored a heterozygous missense mutation in the ZNT2 zinc-binding site, which resulted in defective zinc transport. The other two mothers exhibited multiple heterozygous mutations in the <i>SLC30A2</i> promoter, the first mutations in the <i>SLC30A2</i> regulatory region reported to date.</p><p><strong>Interpretation: </strong>This report provides new genetic insights into TNZD pathogenesis in breastfed infants.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/ca/PED4-7-6.PMC10030689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdisciplinary feeding clinic during the coronavirus disease 2019 pandemic: Implementing telehealth and social determinants of health screening.","authors":"Stephanie Harshman, Desiree Sierra-Velez, Kelly Daigle, Cheryl Hersh, Kristen Risley, Alexy D Arauz Boudreau, Sarah Matathia, Lauren Fiechtner, Meg Simione","doi":"10.1002/ped4.12365","DOIUrl":"10.1002/ped4.12365","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/b5/PED4-7-43.PMC10030687.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9202818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can non-typeable <i>Haemophilus influenzae</i> carriage surveillance data infer antimicrobial resistance associated with otitis media?","authors":"Sophia Bowman-Derrick, Tegan M Harris, Jemima Beissbarth, Mariana Kleinecke, Katrina Lawrence, Teresa M Wozniak, Amy Bleakley, Angela Rumaseb, Michael J Binks, Robyn L Marsh, Peter S Morris, Amanda J Leach, Heidi Smith-Vaughan","doi":"10.1002/ped4.12364","DOIUrl":"10.1002/ped4.12364","url":null,"abstract":"<p><strong>Importance: </strong>In remote communities of the Northern Territory, Australia, children experience high rates of otitis media (OM), commonly caused by non-typeable <i>Haemophilus influenzae</i> (NTHi). Few data exist on antibiotic susceptibility of NTHi from OM.</p><p><strong>Objective: </strong>To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for OM.</p><p><strong>Methods: </strong>NTHi isolates (<i>n</i> = 92) collected from ear discharge between 2003 and 2013 were selected to time- and age-match NTHi isolates from the nasopharyngeal carriage (<i>n</i> = 95). Antimicrobial susceptibility were tested. Phylogenomic trees and a genome-wide association study (GWAS) were performed to determine the similarity of nasopharyngeal and ear isolates at a population level.</p><p><strong>Results: </strong>Among 174 NTHi isolates available for antimicrobial susceptibility testing, 10.3% (18/174) were resistant to ampicillin and 9.2% (16/174) were resistant to trimethoprim-sulfamethoxazole. Small numbers of isolates (≤3) were resistant to tetracycline, chloramphenicol, or amoxicillin-clavulanic acid. There was no statistical difference in the proportion of ampicillin-resistant (<i>P</i> = 0.11) or trimethoprim-sulfamethoxazole-resistant isolates (<i>P</i> = 0.70) between ear discharge and nasopharynx-derived NTHi isolates. Three multi-drug resistant NTHi isolates were identified. Phylogenomic trees showed no clustering of 187 <i>Haemophilus influenzae</i> isolates based on anatomical niche (nasopharynx or ear discharge), and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the GWAS.</p><p><strong>Interpretation: </strong>In this population-level study, nasopharyngeal and ear discharge isolates did not represent distinct microbial populations. These results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of OM in this population.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/ec/PED4-7-13.PMC10030701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubulointerstitial nephritis and uveitis syndrome post-COVID-19.","authors":"Maria Cristina Maggio, Filippo Collura, Maria Michela D'Alessandro, Barbara Gramaglia, Giovanni Corsello","doi":"10.1002/ped4.12362","DOIUrl":"10.1002/ped4.12362","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/cf/PED4-7-57.PMC10030691.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better design leads to better results - Importance of virological outcome design in clinical trials for antiviral treatment of coronavirus disease 2019.","authors":"Getu Zhaori, Lu Lu, Chunyan Liu, Shujing Han, Yongli Guo","doi":"10.1002/ped4.12363","DOIUrl":"10.1002/ped4.12363","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/61/PED4-7-1.PMC10030700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sifrim-Hitz-Weiss/CHD4-related syndrome: A new case report.","authors":"Beibei Zhang, Ming Cheng, Lijun Fan, Chunxiu Gong","doi":"10.1002/ped4.12357","DOIUrl":"10.1002/ped4.12357","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/35/PED4-7-137.PMC10262901.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous regression of tumor in a girl with optic pathway glioma with diencephalic syndrome.","authors":"Rutao Luo, Tianlei Zhang, Wei Yang, Yuanqi Ji, Hailang Sun, Dapeng Li, Ming Ge","doi":"10.1002/ped4.12356","DOIUrl":"10.1002/ped4.12356","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/1c/PED4-7-60.PMC10030698.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9188402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in utilization of online pediatric educational resources during the coronavirus disease 2019 pandemic.","authors":"Dennis Daniel, Anna Krotinger, Traci Wolbrink","doi":"10.1002/ped4.12360","DOIUrl":"10.1002/ped4.12360","url":null,"abstract":"<p><p>The COVID-19 global pandemic disrupted healthcare, society, and medical education. Use of online video educational content increased at the onset of the COVID-19 pandemic, across two platforms. This demonstrates the potential of online videos to provide timely information in a scalable fashion, quickly meeting clinical information needs.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/0a/PED4-7-49.PMC10030686.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}