Pediatric Investigation最新文献

{"title":"Development and validation of the atopic dermatitis and infant skincare knowledge, attitude, and practice (ADISKAP 1.0) scale.","authors":"Xiaoyan Sun, Mutong Zhao, Qiong Wu, Jing Tian, Chunping Shen, Yuan Liang, Shan Wang, Lei Jiao, Yang Wang, Mingyi Liu, Lin Ma, Xiuhua Ma","doi":"10.1002/ped4.12374","DOIUrl":"10.1002/ped4.12374","url":null,"abstract":"<p><strong>Importance: </strong>Preserving skin health is crucial for atopic dermatitis control as well as for the thriving of children. However, a well-developed and validated tool that measures the knowledge, attitude, and practice of skin care is lacking.</p><p><strong>Objective: </strong>To develop and validate the atopic dermatitis and infant skincare knowledge, attitude, and practice (ADISKAP 1.0) scale that measures parental health literacy on atopic dermatitis and skin care.</p><p><strong>Methods: </strong>We conducted a review of the literature, a focus group (two dermatologists and 12 parents), and a panel discussion in order to generate the ADISKAP prototype. Two samples of parents with knowingly superior (dermatologists, <i>n</i> = 59) and inferior (general population, <i>n</i> = 395) knowledge traits participated in the validation of ADISKAP. Cronbach's alpha was reported as a measure of internal consistency, and the intraclass correlation coefficient (ICC) was calculated to assess the test-retest validity. The known-groups technique was used to evaluate construct validity.</p><p><strong>Results: </strong>The ADISKAP scale contained 17 items after content and face validity validation. After removing items that displayed poor test-retest reliability (<i>n</i> = 4) and construct validity (<i>n</i> = 3), 12 items were retained in the ADISKAP 1.0.</p><p><strong>Interpretation: </strong>ADISKAP 1.0 is a reliable and valid tool for assessing parental knowledge, attitude, and practice on infantile atopic dermatitis and skin care.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 3","pages":"153-162"},"PeriodicalIF":1.9,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/76/PED4-7-153.PMC10509389.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41148402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the surgical stress in open and laparoscopic treatment of inguinal hernia in children.","authors":"Charikleia D Demiri, Christos Kaselas, Stavros Iliadis, Maria Tsopozidi, Ioannis Spyridakis","doi":"10.1002/ped4.12372","DOIUrl":"10.1002/ped4.12372","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 2","pages":"71-74"},"PeriodicalIF":1.9,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fe/13/PED4-7-71.PMC10262887.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of <i>Haemophilus Influenzae</i> serotype a intracranial infections in older children.","authors":"Varvara Probst, Fadi Shahoud, Aaron Fletcher Osborne, Ana Alvarez, Nizar Maraqa, Ayesha Mirza","doi":"10.1002/ped4.12369","DOIUrl":"10.1002/ped4.12369","url":null,"abstract":"<p><strong>Introduction: </strong><i>Haemophilus influenzae</i> (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.</p><p><strong>Case presentation: </strong>We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.</p><p><strong>Conclusion: </strong>Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 2","pages":"132-136"},"PeriodicalIF":1.9,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/ef/PED4-7-132.PMC10262899.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital cutaneous mastocytosis mistaken for non-accidental injury.","authors":"Emma Porter, Cynthia Heffron, Lesley Ann Murphy, Cathal O'Connor","doi":"10.1002/ped4.12370","DOIUrl":"10.1002/ped4.12370","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 3","pages":"218-219"},"PeriodicalIF":1.9,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/24/PED4-7-218.PMC10509383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to magnesium sulfate and adrenocorticotropic hormone combination therapy for infantile spasms with failed first-line treatments.","authors":"Qiuhong Wang, Wen He, Yangyang Wang, Liying Liu, Mengna Zhang, Xiaoyan Yang, Liping Zou","doi":"10.1002/ped4.12368","DOIUrl":"10.1002/ped4.12368","url":null,"abstract":"<p><strong>Importance: </strong>Infantile spasm (IS) is a kind of refractory epilepsy. The first-line treatments for IS are adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.</p><p><strong>Objective: </strong>This study aimed to evaluate the efficacy of magnesium sulfate and ACTH (MgSO₄+ACTH) combination therapy in patients with IS who failed first-line treatments.</p><p><strong>Methods: </strong>In this retrospective study, the clinical data of patients with IS who failed first-line treatments were collected in the Chinese PLA General Hospital. Patients received MgSO₄+ACTH combination therapy after first-line treatments failed. The course of treatments was 2 weeks. The therapeutic dose of ACTH and MgSO₄ was 2.5 U·kg^-1·d^-1 and 0.25 g·kg^-1·d^-1, respectively.</p><p><strong>Results: </strong>A total of 229 patients with IS who failed the first-line treatments were collected. At the end of the MgSO₄+ACTH combination treatment, the seizure-free rate was 48.5% (111/229), and the resolution of hypsarrhythmia on electroencephalogram (EEG) was 72.1% (165/229). About 21.4% (49/229) of patients showed side effects, including infectious diseases, hypokalemia, and diarrhea.</p><p><strong>Interpretation: </strong>For patients with IS who failed first-line treatments, in terms of the seizure-free rate and resolution of hypsarrhythmia on EEG, MgSO₄+ACTH combination therapy can be considered.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"29-35"},"PeriodicalIF":1.9,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/81/PED4-7-29.PMC10030695.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instruction for Authors.","authors":"","doi":"10.1002/ped4.12371","DOIUrl":"https://doi.org/10.1002/ped4.12371","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"63-70"},"PeriodicalIF":2.2,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/8a/PED4-7-63.PMC10030699.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9174888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.","authors":"Qiaoyu Shi,&nbsp;Kemin Qi","doi":"10.1002/ped4.12367","DOIUrl":"10.1002/ped4.12367","url":null,"abstract":"<p><p>Most epidemiological and experimental studies have focused on maternal influences on offspring's health. The impact of maternal undernutrition, overnutrition, hypoxia, and stress is linked to adverse offspring outcomes across a range of systems including cardiometabolic, respiratory, endocrine, and reproduction among others. During the past decade, it has become evident that paternal environmental factors are also linked to the development of diseases in offspring. In this article, we aim to outline the current understanding of the impact of male health and environmental exposure on offspring development, health, and disease and explore the mechanisms underlying the paternal programming of offspring health. The available evidence suggests that poor paternal pre-conceptional nutrition and lifestyle, and advanced age can increase the risk of negative outcomes in offspring, via both direct (genetic/epigenetic) and indirect (maternal uterine environment) effects. Beginning at preconception, and during utero and the early life after birth, cells acquire an epigenetic memory of the early exposure which can be influential across the entire lifespan and program a child's health. Potentially not only mothers but also fathers should be advised that maintaining a healthy diet and lifestyle is important to improve offspring health as well as the parental health status. However, the evidence is mostly based on animal studies, and well-designed human studies are urgently needed to verify findings from animal data.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 2","pages":"111-131"},"PeriodicalIF":2.2,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/11/PED4-7-111.PMC10262906.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10298023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel <i>SLC30A2</i> mutations in the pathogenesis of transient neonatal zinc deficiency.","authors":"Taichiro Muto, Yuriko Kawase, Kaori Aiba, Miyuki Okuma, Naoya Itsumura, Shuangyu Luo, Namino Ogawa, Tokuji Tsuji, Taiho Kambe","doi":"10.1002/ped4.12366","DOIUrl":"10.1002/ped4.12366","url":null,"abstract":"<p><strong>Importance: </strong>Transient neonatal zinc deficiency (TNZD) occurs in breastfed infants due to abnormally low breast milk zinc levels. Mutations in the solute carrier family 30 member 2 (<i>SLC30A2</i>) gene, which encodes the zinc transporter ZNT2, cause low zinc concentration in breast milk.</p><p><strong>Objective: </strong>This study aimed to provide further insights into TNZD pathophysiology.</p><p><strong>Methods: </strong><i>SLC30A2</i> sequencing was performed in three unrelated Japanese mothers, whose infants developed TNZD due to low-zinc milk consumption. The effects of the identified mutations were examined using cell-based assays and luciferase reporter analysis.</p><p><strong>Results: </strong>Novel <i>SLC30A2</i> mutations were identified in each mother. One harbored a heterozygous missense mutation in the ZNT2 zinc-binding site, which resulted in defective zinc transport. The other two mothers exhibited multiple heterozygous mutations in the <i>SLC30A2</i> promoter, the first mutations in the <i>SLC30A2</i> regulatory region reported to date.</p><p><strong>Interpretation: </strong>This report provides new genetic insights into TNZD pathogenesis in breastfed infants.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"6-12"},"PeriodicalIF":1.9,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/ca/PED4-7-6.PMC10030689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdisciplinary feeding clinic during the coronavirus disease 2019 pandemic: Implementing telehealth and social determinants of health screening.","authors":"Stephanie Harshman, Desiree Sierra-Velez, Kelly Daigle, Cheryl Hersh, Kristen Risley, Alexy D Arauz Boudreau, Sarah Matathia, Lauren Fiechtner, Meg Simione","doi":"10.1002/ped4.12365","DOIUrl":"10.1002/ped4.12365","url":null,"abstract":"","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"43-48"},"PeriodicalIF":1.9,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/b5/PED4-7-43.PMC10030687.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9202818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can non-typeable <i>Haemophilus influenzae</i> carriage surveillance data infer antimicrobial resistance associated with otitis media?","authors":"Sophia Bowman-Derrick, Tegan M Harris, Jemima Beissbarth, Mariana Kleinecke, Katrina Lawrence, Teresa M Wozniak, Amy Bleakley, Angela Rumaseb, Michael J Binks, Robyn L Marsh, Peter S Morris, Amanda J Leach, Heidi Smith-Vaughan","doi":"10.1002/ped4.12364","DOIUrl":"10.1002/ped4.12364","url":null,"abstract":"<p><strong>Importance: </strong>In remote communities of the Northern Territory, Australia, children experience high rates of otitis media (OM), commonly caused by non-typeable <i>Haemophilus influenzae</i> (NTHi). Few data exist on antibiotic susceptibility of NTHi from OM.</p><p><strong>Objective: </strong>To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for OM.</p><p><strong>Methods: </strong>NTHi isolates (<i>n</i> = 92) collected from ear discharge between 2003 and 2013 were selected to time- and age-match NTHi isolates from the nasopharyngeal carriage (<i>n</i> = 95). Antimicrobial susceptibility were tested. Phylogenomic trees and a genome-wide association study (GWAS) were performed to determine the similarity of nasopharyngeal and ear isolates at a population level.</p><p><strong>Results: </strong>Among 174 NTHi isolates available for antimicrobial susceptibility testing, 10.3% (18/174) were resistant to ampicillin and 9.2% (16/174) were resistant to trimethoprim-sulfamethoxazole. Small numbers of isolates (≤3) were resistant to tetracycline, chloramphenicol, or amoxicillin-clavulanic acid. There was no statistical difference in the proportion of ampicillin-resistant (<i>P</i> = 0.11) or trimethoprim-sulfamethoxazole-resistant isolates (<i>P</i> = 0.70) between ear discharge and nasopharynx-derived NTHi isolates. Three multi-drug resistant NTHi isolates were identified. Phylogenomic trees showed no clustering of 187 <i>Haemophilus influenzae</i> isolates based on anatomical niche (nasopharynx or ear discharge), and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the GWAS.</p><p><strong>Interpretation: </strong>In this population-level study, nasopharyngeal and ear discharge isolates did not represent distinct microbial populations. These results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of OM in this population.</p>","PeriodicalId":19992,"journal":{"name":"Pediatric Investigation","volume":"7 1","pages":"13-22"},"PeriodicalIF":1.9,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/ec/PED4-7-13.PMC10030701.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}