Patient preference and adherence最新文献

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Perspectives on Treatment Decisions, Preferences, and Adherence and Long-Term Management in Asthma and COPD: A Qualitative Analysis of Patient, Caregiver, and Healthcare Provider Insights. 关于哮喘和慢性阻塞性肺病的治疗决定、偏好、依从性和长期管理的观点:对患者、护理者和医疗保健提供者见解的定性分析。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S467870
Miguel Román-Rodríguez, Ilona McMullan, Michelle Warner, Christopher H Compton, Ruth Tal-Singer, Jean M Orlow, MeiLan K Han
{"title":"Perspectives on Treatment Decisions, Preferences, and Adherence and Long-Term Management in Asthma and COPD: A Qualitative Analysis of Patient, Caregiver, and Healthcare Provider Insights.","authors":"Miguel Román-Rodríguez, Ilona McMullan, Michelle Warner, Christopher H Compton, Ruth Tal-Singer, Jean M Orlow, MeiLan K Han","doi":"10.2147/PPA.S467870","DOIUrl":"10.2147/PPA.S467870","url":null,"abstract":"<p><strong>Purpose: </strong>Asthma and chronic obstructive pulmonary disease (COPD) are associated with substantial morbidity and mortality. This analysis assessed patient, caregiver, and healthcare provider (HCP) opinions regarding asthma and COPD diagnosis and treatment, including inhaler device preferences.</p><p><strong>Patients and methods: </strong>Insights were from: (1) face-to-face/telephone patient/HCP communications with GSK Global Medical Teams; (2) social media listening; (3) a self-completed online patient/caregiver survey. Data were anonymized and informed consent was provided. Qualitative outputs were extracted, analyzed inductively, and coded per key themes, such as treatment preferences (including perceptions of single inhaler triple therapy [SITT] versus multiple inhaler triple therapy [MITT]) and long-term treatment goals. Data could be assigned to ≥1 theme.</p><p><strong>Results: </strong>Overall, 2966 patient and HCP insights (patients, 1150; HCPs, 1816), 988 social media posts, and 44 survey responses (patients, 33; caregivers, 11) were included. Within this analysis, some patients delayed seeking medical advice due to lack of disease understanding and used alternative information sources to better understand treatment options (eg, social media). Patients preferred SITT over MITT in terms of convenience, ease of use, and perceived efficacy; some believed that MITT provided greater coverage due to frequent dosing. HCPs recognized the tendency of patient preferences to drive treatment decisions, and highlighted a reluctance to change therapy among some patients, particularly those well controlled in current therapy. Patients preferred therapies with a shorter onset of action. Patients tended to measure treatment success by symptom improvement and quality of life, whereas HCPs measured treatment success through clinical tests. HCPs reported a lack of patient awareness of the mortality risk associated with COPD.</p><p><strong>Conclusion: </strong>There is discordance between patient and HCP perceptions of treatment success and goals in asthma and COPD. Improved patient education and HCP-patient communication are needed to facilitate meaningful shared decision-making, optimize care plans, and provide early treatment options.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2295-2306"},"PeriodicalIF":2.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-Sectional Study Identifying Medication Adherence Technologies (MATech) in Sweden Using Behavior Change Techniques. 利用行为改变技术识别瑞典坚持用药技术 (MATech) 的横断面研究。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S481152
Marie Ekenberg, Fanny Landin, Björn Wettermark
{"title":"A Cross-Sectional Study Identifying Medication Adherence Technologies (MATech) in Sweden Using Behavior Change Techniques.","authors":"Marie Ekenberg, Fanny Landin, Björn Wettermark","doi":"10.2147/PPA.S481152","DOIUrl":"10.2147/PPA.S481152","url":null,"abstract":"<p><strong>Background: </strong>Poor medication adherence is a well-recognized problem, and behavior change techniques (BCTs) have shown promise in improving patient adherence to prescribed drug treatment. Through the utilization of medication adherence technologies (MATech), these BCT interventions could be delivered effectively in a person-centered way. MATech can be defined as systems, services or physical devices (hardware), with a digital component, used to support patients in their drug utilization. However, there is a lack of knowledge regarding their availability and to what extent they apply evidence-based BCTs.</p><p><strong>Purpose: </strong>This study aimed to identify and describe MATech with BCT interventions available in the Swedish language.</p><p><strong>Methods: </strong>A cross-sectional survey study was conducted in 2023. After identifying potential MATech developers by contacting umbrella organizations in the private sector, public agencies and regions, and conducting an app search, a survey was distributed to 381 potential MATech developers. Included MATech were in Swedish, used by patients, incorporated a BCT intervention, and had survey response from the developer. The survey was based on the BCT taxonomy and the framework of attributes from the COST ENABLE project, and included questions regarding BCT features. Following correspondence with 189 potential developers, 32 with products of interest responded to the survey, and 21 MATech were identified (12 standalone software and nine hardware solutions).</p><p><strong>Results: </strong>Among the 21 MATech identified, nine were hardware and ten were specifically designed for a particular disease or medication. The majority of technologies incorporated BCTs of reminding the patient to take the medication (81%), information about the treatment (71%) and providing feedback on the monitoring of medication adherence or clinical outcomes (76%).</p><p><strong>Conclusion: </strong>Swedish-language MATech employing BCTs are available, encompassing both hardware and software solutions. There is a need to enhance the visibility of these technologies, enabling patients to discover and utilize the support they provide.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2281-2293"},"PeriodicalIF":2.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacovigilance in Action: Utilizing VigiBase Data to Improve Clozapine Safety. 药物警戒在行动:利用 VigiBase 数据提高氯氮平的安全性。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-12 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S495254
Carlos De Las Cuevas, Emilio J Sanz, Jose de Leon
{"title":"Pharmacovigilance in Action: Utilizing VigiBase Data to Improve Clozapine Safety.","authors":"Carlos De Las Cuevas, Emilio J Sanz, Jose de Leon","doi":"10.2147/PPA.S495254","DOIUrl":"10.2147/PPA.S495254","url":null,"abstract":"<p><strong>Purpose: </strong>Clozapine is an antipsychotic which was approved in 1989 for treatment-resistant schizophrenia in the United States (US). There were few randomized trials before its approval and potentially lethal clozapine adverse drug reactions (ADRs), such as agranulocytosis and myocarditis were identified by pharmacovigilance. VigiBase, the WHO global database, is a cornerstone of international pharmacovigilance efforts for ADR identification during post-marketing surveillance. This systematic review of the literature explores additional contributions to the knowledge of clozapine ADRs from recent VigiBase studies.</p><p><strong>Methods: </strong>Using the terms \"clozapine AND VigiBase\" we conducted an article search in PubMed on September 5, 2024. Of the 29 articles, 11 were excluded and 18 described in the Results section.</p><p><strong>Results: </strong>All clozapine ADRs were described in two VigiBase studies. One on pregnancy indicated no increased risk with clozapine compared with other antipsychotics; the other reported 191,557 clozapine ADRs, including 22,956 fatal outcomes through January 15, 2023, and paid attention to the reporting style of the top 4 reporting countries (the US, the United Kingdom, Canada and Australia). Infections were described in three VigiBase studies where clozapine treatment was associated with infections, respiratory aspiration, and pneumonia. Rapid titration can lead to localized clozapine-induced inflammations including myocarditis, pericarditis or pancreatitis, or generalized inflammations such as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. Clozapine-induced inflammation was described in four VigiBase studies, two focused on all ages (myocarditis and DRESS) and two on youth (myocarditis and another on pericarditis and pancreatitis). Other specific ADRs were described in nine VigiBase studies (hematological malignancies, rhabdomyolysis, sialorrhea, seizures, diabetes mellitus, drug-induced parkinsonism, withdrawal symptoms, and suicidal behaviors).</p><p><strong>Conclusion: </strong>The spectrum of respiratory aspiration - aspiration pneumonia - pneumonia and other infections are significant causes of fatal outcomes in clozapine-treated patients. Clozapine had anti-suicidal effects versus other antipsychotics across all VigiBase labels of suicidal behavior.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2261-2280"},"PeriodicalIF":2.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Investigation into the Determinants of Unfulfilled Needs in Caregivers of Patients with Phenylketonuria. 苯丙酮尿症患者护理者未满足需求的决定因素定性调查。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-08 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S481857
Yu-Juan Zheng, Yong-Chao Hou, Hua Zhao, Xiao-Yun Wang, Yu-Dan Liu, Li Li, Liang Yu, Ming-Mei Guo
{"title":"A Qualitative Investigation into the Determinants of Unfulfilled Needs in Caregivers of Patients with Phenylketonuria.","authors":"Yu-Juan Zheng, Yong-Chao Hou, Hua Zhao, Xiao-Yun Wang, Yu-Dan Liu, Li Li, Liang Yu, Ming-Mei Guo","doi":"10.2147/PPA.S481857","DOIUrl":"https://doi.org/10.2147/PPA.S481857","url":null,"abstract":"<p><strong>Objective: </strong>To conduct an in-depth exploration of the factors influencing unfulfilled needs in caregivers of patients with phenylketonuria.</p><p><strong>Methods: </strong>A rapid qualitative analysis approach was used to conduct semi-structured interviews with 16 caregivers of patients with phenylketonuria undergoing specialized dietary interventions, along with 5 medical professionals, within a designated phenylketonuria diagnosis and treatment center in Shanxi Province. Interview data were systematically organized, analyzed, and thematically extracted.</p><p><strong>Results: </strong>Four primary themes were extracted: self-imposed constraints (including insufficient caregiver engagement, economic limitations, and stigma); interpersonal constraints (encompassing social isolation, inadequate social support networks, and lack of doctor-patient interactions); structural limitation factors (inadequate provision of specialized professional support systems, lack of medical dietary supplements, and deficiencies in national policies); and experiential limitation factors (encompassing sensory perceptions of medical dietary supplements and insufficient continuity in psycho-emotional care).</p><p><strong>Conclusion: </strong>The unfulfilled needs of caregivers of patients with phenylketonuria primarily manifest across four dimensions. Greater emphasis on addressing these needs is warranted, necessitating increased attention to patients with phenylketonuria and their caregivers. Specifically, the focus should be directed toward addressing their emotional requirements, along with proactive development of the medical service infrastructure. Such measures are imperative for reducing unfulfilled needs among caregivers of patients and enhancing their prognosis.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2249-2259"},"PeriodicalIF":2.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing and Validating an Epilepsy Awareness and Education Program: Bridging Gaps in Knowledge and Support for People Living with Epilepsy and Their Families. 开发并验证癫痫认知和教育计划:缩小癫痫患者及其家人在知识和支持方面的差距。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S463151
Ofhani Prudance Musekwa, Lufuno Makhado, Angelina Maphula
{"title":"Developing and Validating an Epilepsy Awareness and Education Program: Bridging Gaps in Knowledge and Support for People Living with Epilepsy and Their Families.","authors":"Ofhani Prudance Musekwa, Lufuno Makhado, Angelina Maphula","doi":"10.2147/PPA.S463151","DOIUrl":"https://doi.org/10.2147/PPA.S463151","url":null,"abstract":"<p><p>Various epilepsy studies on epilepsy awareness and knowledge highlight underlying myths, misconceptions, stigma, and discrimination associated with epilepsy, People Living with Epilepsy (PLWE), and their families. This study aimed to develop an epilepsy awareness and education programme to enhance epilepsy awareness and support among individuals living with epilepsy and their families. Participatory Action Research (PAR) laid the ground for the programme's investigation, development, and implementation. The study stakeholders (co-researchers) included PLWE, family members and caregivers (FMCs), community members, and health care providers (HCPs) who participated in the inception of the study, data collection, programme development, and validation. The study included four phases: phase one was a systematic review, phase two was an empirical phase that included an explanatory sequential mixed method, phase three was meta-inferences and conceptualization, and the last phase was the development and validation of the programme. All phases of the study informed the development of the programme (using a step-step guide to programme development). From these, the gaps and potential education needs were identified. Gaps such as insufficient knowledge about epilepsy in rural communities, negative attitudes and satisfactory awareness, and a need for support and care for PLWE and FMCs. Implementation of this programme will improve epilepsy knowledge, care, and support in marginalised communities, establishing a more conducive environment and ultimately improving the quality of life for patients and their families.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2235-2248"},"PeriodicalIF":2.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intake Patterns and Experiences of Patients Using Direct Oral Anticoagulants Measured by Electronic Monitoring in Community Pharmacies. 通过社区药房电子监控系统测量直接口服抗凝剂患者的摄入模式和经历。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S469910
Sara Desmaele, Andreas Capiau, Maxim Grymonprez, Antoine Pironet, Stephane Steurbaut, Silas Rydant
{"title":"Intake Patterns and Experiences of Patients Using Direct Oral Anticoagulants Measured by Electronic Monitoring in Community Pharmacies.","authors":"Sara Desmaele, Andreas Capiau, Maxim Grymonprez, Antoine Pironet, Stephane Steurbaut, Silas Rydant","doi":"10.2147/PPA.S469910","DOIUrl":"https://doi.org/10.2147/PPA.S469910","url":null,"abstract":"<p><strong>Purpose: </strong>Several international organizations advocate for monitoring of adherence to direct oral anticoagulants (DOACs), given the prevalent issue of suboptimal adherence to DOACs. The aim was to investigate intake patterns in patients on DOAC therapy by electronic monitoring of medication adherence in community pharmacies (using a Medication Event Monitoring System<sup>®</sup> (MEMS<sup>®</sup>)-device), and to assess patients' experiences with this device.</p><p><strong>Patients and methods: </strong>Patients using apixaban, rivaroxaban or edoxaban and visiting a community pharmacy, were included. Adherence was electronically monitored over a twelve-week period. Pharmacists conducted data readings from the electronic device at six and twelve weeks, and discussed these data with the patients. At the beginning and end of the study, patients completed a questionnaire about their expectations and experiences respectively.</p><p><strong>Results: </strong>Eighty-nine patients were included and high taking adherence rates were observed (median adherence of 100% for once-daily dosed patients and 96.7% for twice-daily dosed patients), but more than half of the patients took at least one dose too late or skipped at least one dose, possibly resulting in temporarily reduced protection against thromboembolic events. Most patients who felt that their adherence had improved, believed this was due to the combination of the electronic device and the personal follow-up by the pharmacist. Although most patients stated that medication adherence is their own responsibility, they were grateful for the support they received from their community pharmacist.</p><p><strong>Conclusion: </strong>High adherence rates were observed, but there was still room for improvement regarding intake moments. Positive experiences with an electronic device for medication adherence monitoring were reported.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2225-2234"},"PeriodicalIF":2.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11550688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mediating Effect of Perceived Health Competence on the Association Between Mindfulness and Adherence to Health Behaviors in Patients with Acute Coronary Syndrome: A Cross-Sectional Study. 认知健康能力对急性冠状动脉综合征患者正念与坚持健康行为之间关系的中介效应:一项横断面研究
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S487100
Anan Li, Yangfan Nie, Meixuan Chi, Naijuan Wang, Siying Ji, Zhaoying Zhu, Shan Li, Yunying Hou
{"title":"Mediating Effect of Perceived Health Competence on the Association Between Mindfulness and Adherence to Health Behaviors in Patients with Acute Coronary Syndrome: A Cross-Sectional Study.","authors":"Anan Li, Yangfan Nie, Meixuan Chi, Naijuan Wang, Siying Ji, Zhaoying Zhu, Shan Li, Yunying Hou","doi":"10.2147/PPA.S487100","DOIUrl":"https://doi.org/10.2147/PPA.S487100","url":null,"abstract":"<p><strong>Purpose: </strong>Given the importance of adherence to health behaviors in patients with acute coronary syndrome (ACS) and the potential influence of mindfulness, it is important to determine the association between mindfulness and adherence to health behaviors and its potential mechanisms in this population. Perceived health competence is a person's confidence in his/her ability to achieve health goals successfully and may explain how mindfulness influences adherence to health behaviors. This study aimed to examine the association between mindfulness and adherence to health behaviors and whether this association was mediated by perceived health competence.</p><p><strong>Methods: </strong>A cross-sectional study (N = 555) was conducted at the First Affiliated Hospital of Soochow University from September 2022 to January 2024. Patients' sociodemographic and clinical data, mindfulness (Mindful Attention Awareness Scale [MAAS]), and perceived health competence (Perceived Health Competence Scale [PHCS]) were assessed one-two days before discharge, and adherence to health behaviors (Medical Outcomes Study Specific Adherence Scale [MOSSAS]) was assessed one month after discharge. Good adherence to health behaviors was defined as achieving a cumulative score of ≥ 80%. A mediating effect model was used to analyze data.</p><p><strong>Results: </strong>The mean score of adherence to health behaviors was 42.58 ± 7.13 and only 27.39% (152/555) of the patients had good adherence. Mindfulness positively predicted adherence to health behaviors (β = 0.13, <i>P</i> < 0.01). Perceived health competence partially mediated the association between mindfulness and adherence to health behaviors, with the mediating effect accounting for 7.00% of the total effect (<i>P</i> = 0.03).</p><p><strong>Conclusion: </strong>The adherence to health behaviors in patients with ACS was very low. Mindfulness positively predicted adherence to health behaviors, and perceived health competence partially mediated the association between mindfulness and adherence to health behaviors. Healthcare providers could intervene patients' mindfulness or perceived health competence to improve adherence to health behaviors.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2203-2215"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Omidubicel for Hematopoietic Cell Transplants: Considerations for Patients and Treatment Outcomes. 用于造血细胞移植的 Omidubicel:患者的注意事项和治疗结果。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S419253
Allison L Morse, Hana Kurz, Donald C Moore
{"title":"Omidubicel for Hematopoietic Cell Transplants: Considerations for Patients and Treatment Outcomes.","authors":"Allison L Morse, Hana Kurz, Donald C Moore","doi":"10.2147/PPA.S419253","DOIUrl":"https://doi.org/10.2147/PPA.S419253","url":null,"abstract":"<p><p>For patients with hematologic malignancies requiring allogeneic stem cell transplantation, alternative donor sources are needed when lacking access to a matched related or unrelated donor. Umbilical cord blood (UCB) has been an important alternative allograft donor source for these patients; however, several limitations exist. Omidubicel is a nicotinamide modified allogeneic hematopoietic progenitor cell therapy derived from UCB. Omidubicel was approved in May 2023 by the United States Food and Drug Administration based on the results of a Phase III trial comparing it to UCB transplantation in patients with high-risk hematologic malignancies. Median time to neutrophil engraftment was faster with omidubicel compared to UCB transplantation (12 days vs 22 days; p<0.001). There was also a lower incidence of grade 2/3 bacterial or invasive fungal infections with omidubicel compared to UCB transplantation (37% vs 57%; p=0.027). From a safety perspective, omidubicel has a boxed warning due to the risk of life-threatening infusion reactions, graft-versus-host disease, graft failure, and engraftment syndrome. Omidubicel represents an important advancement in developing novel alternative allograft donor sources. This also has important implications in ensuring access to alternative donor sources for ethnic and minority populations.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2217-2223"},"PeriodicalIF":2.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Perspectives on and Preferences for an Enhanced Neonatal Jaundice Education Program: An Evaluation Using the Consolidated Framework for Implementation Research. 产妇对新生儿黄疸强化教育计划的看法和偏好:使用实施研究综合框架进行评估。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S486921
Businge Alinaitwe, Faith Sharon Kisakye, Charles Kato, Francis Nkunzimaana, Elizabeth Ayebare, Jameel J Winter, Tom Denis Ngabirano
{"title":"Maternal Perspectives on and Preferences for an Enhanced Neonatal Jaundice Education Program: An Evaluation Using the Consolidated Framework for Implementation Research.","authors":"Businge Alinaitwe, Faith Sharon Kisakye, Charles Kato, Francis Nkunzimaana, Elizabeth Ayebare, Jameel J Winter, Tom Denis Ngabirano","doi":"10.2147/PPA.S486921","DOIUrl":"10.2147/PPA.S486921","url":null,"abstract":"<p><strong>Introduction: </strong>Neonatal mortality is a major contributor to under-five deaths yet the main causes of these deaths are preventable. Postnatal health education programs can improve timely detection and care seeking for newborn morbidities such as neonatal jaundice (NNJ). Being a common occurrence in low-income countries, it is surprising that women do not have sufficient knowledge about NNJ. Although the knowledge can be improved through routine education programs, healthcare providers rarely engage women in evaluating such programs, which limits their uptake and sustainability.</p><p><strong>Methods: </strong>This was a qualitative study evaluating a postnatal neonatal jaundice health education program conducted at Jinja Regional Referral Hospital (JRRH). Narrative data on the structure, design, and delivery of the program was recorded from 12 postnatal women through unstructured interviews. The participants were those who had taken part in an enhanced NNJ education program. Qualitative content analysis, guided by the Consolidated Framework for Implementation Research (CFIR) was performed.</p><p><strong>Results: </strong>Using the CFIR, two themes were identified; the intervention characteristics domain and the individual domains. The constructs under these domains were intervention design quality and packaging, relative advantage, and maternal knowledge needs. The augmented nature of the intervention, sorting individual needs, ability to promote continuity of care, and care-seeking were identified as key facilitators. Lack of group interaction was identified by some women as a possible barrier.</p><p><strong>Conclusion: </strong>Overall, the education program was positively perceived by women and preferred compared to the conventional method of health education. In low-resource settings where maternal health education can contribute to a reduction in newborn mortality, the design, implementation, and evaluation of maternal education programs should be informed by women's preferences. Healthcare providers should utilize multiple sources of information and routinely practice patient-centered evaluation to meet the changing knowledge demands of postnatal women.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"18 ","pages":"2187-2202"},"PeriodicalIF":2.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inpatient Satisfaction on Non-Pharmacological Interventions for Acute Settings: A Systematic Review. 住院病人对急诊非药物干预措施的满意度:系统回顾。
IF 2 3区 医学
Patient preference and adherence Pub Date : 2024-10-27 eCollection Date: 2024-01-01 DOI: 10.2147/PPA.S485369
Shaherah Yousef Andargeery, Abdullah Ahmed Almalki, Nada Aljohani, Hanan Alyami, Abdulrhman Alhagbani
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