Fernando D Bustos-Gajardo, Rodrigo Adasme Jeria, Thomas Piraino, Pablo Cruces, L Felipe Damiani
{"title":"Clinical Outcomes of Children Meeting the At-Risk for PARDS Criteria Before PICU Admission: A Single-Center Study.","authors":"Fernando D Bustos-Gajardo, Rodrigo Adasme Jeria, Thomas Piraino, Pablo Cruces, L Felipe Damiani","doi":"10.1002/ppul.71146","DOIUrl":"10.1002/ppul.71146","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the ability of the criteria \"At-risk for PARDS\" to identify patients with acute respiratory infection hospitalized outside the pediatric intensive care unit (PICU) who are at high risk of developing pediatric acute respiratory distress syndrome (PARDS) and describe the timing for the identification. The secondary aim was to explore clinical outcome differences between patients with and without risk for PARDS.</p><p><strong>Methods: </strong>We conducted an observational prospective cohort study from June to August 2019. Children under 15 years old hospitalized in a pediatric ward due to an acute respiratory tract infection were included.</p><p><strong>Main results: </strong>A total of 177 patients with a median age of 12 (IQR 5; 25) months were included. Registered data included demographics, respiratory support, at-risk for PARDS and PARDS diagnosis according to PALICC consensus. PICU admission, hospital length of stay (LOS) and intrahospital mortality were the outcomes compared between children with and without risk for PARDS. The at-risk criteria, within 48 h of admission, showed an overall accuracy, sensitivity, and specificity of 82.5%, 100%, and 81.9% respectively, to detect patients that progress to PARDS. The at-risk for PARDS criteria was met in 37 cases (20.9%), which also were more likely to developed PARDS (6/37 [16.2%] vs. 0/140 [0%]; p < 0.001), had higher admission to PICU (16/37 [43.2%] vs. 0 [0%]; p < 0.001) and hospital LOS (7 [6; 12] days vs. 5 [3-6] days; p < 0.001), compared with the group without at-risk for PARDS.</p><p><strong>Conclusions: </strong>The at-risk for PARDS criteria within 48 h of admission demonstrated an adequate ability to identify patients with a respiratory infection at increased risk of developing PARDS. Patients who met the at-risk for PARDS criteria before PICU admission presented with unfavorable clinical outcomes compared with those without risk.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71146"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabrizio Racca, Jonathan D Finder, Eugenio Mercuri, Andrea Vianello, Michelle Chatwin, Alessandro Amaddeo, Grazia Crescimanno, Federica Trucco, Daniel W Sheehan, Luigi Barberis, Filippo Buccella, Jodi Wolff, Sherri L Katz, David J Birnkrant
{"title":"Current Standards and Future Directions of Duchenne Muscular Dystrophy Respiratory Care: The PPMD Italy Meeting Report.","authors":"Fabrizio Racca, Jonathan D Finder, Eugenio Mercuri, Andrea Vianello, Michelle Chatwin, Alessandro Amaddeo, Grazia Crescimanno, Federica Trucco, Daniel W Sheehan, Luigi Barberis, Filippo Buccella, Jodi Wolff, Sherri L Katz, David J Birnkrant","doi":"10.1002/ppul.71113","DOIUrl":"10.1002/ppul.71113","url":null,"abstract":"<p><strong>Objective: </strong>This report summarizes key discussions from the meeting \"Current Standards and Future Directions of Respiratory Assessment and Management of Duchenne Muscular Dystrophy (DMD),\" organized by Parent Project Muscular Dystrophy (PPMD) Italy and the United States to address current challenges and opportunities in DMD respiratory care.</p><p><strong>Methods: </strong>The meeting brought together researchers, clinicians, and patient advocates who shared experiences, discussed advancements in DMD respiratory management, and identified areas of debate that require further research.</p><p><strong>Results: </strong>The speakers emphasized routine assessment of pulmonary function and of breathing during sleep to achieve timely diagnosis of respiratory complications. Therapeutic discussions focused on airway clearance and assisted ventilation, highlighting noninvasive ventilation (NIV) as the preferred modality, even for advanced respiratory failure. The respiratory implications of new pharmacological therapies were discussed. The speakers endorsed the importance of cardiorespiratory outcomes in assessments of drug efficacy. To assess a drug's clinical impact and to define current respiratory phenotypes, the trajectory of the absolute value of forced vital capacity (FVC) was proposed as a potentially better parameter than FVC percent predicted, which is favored in current drug studies. In regard to management of acute respiratory failure and perioperative situations, standards of care and areas needing future research were identified.</p><p><strong>Conclusion: </strong>In this meeting, many points of consensus emerged, as well as areas requiring further research. The necessity to involve patients and their families in all aspects of respiratory care was emphasized, as well as the need for patient centered outcomes in medical decision making and research.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71113"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ross J Langley, Holly Hamilton, Steve Turner, Elizabeth Watt, Frankie Posner, Kenneth A Macleod
{"title":"E-Cigarette Education and Training in Medical Schools: A National Survey.","authors":"Ross J Langley, Holly Hamilton, Steve Turner, Elizabeth Watt, Frankie Posner, Kenneth A Macleod","doi":"10.1002/ppul.71125","DOIUrl":"https://doi.org/10.1002/ppul.71125","url":null,"abstract":"<p><strong>Introduction: </strong>E-cigarette use is increasing amongst current smokers, nonsmoking adults and young people. Doctors are in a unique position to encourage patients to quit and help achieve their goal of nicotine abstinence. Teaching on tobacco-related disease is well established and a \"smoking history\" is a routine part of undergraduate medical curricula. Despite education about smoking, little is known about what students are taught about E-cigarettes.</p><p><strong>Methods: </strong>Scottish medical students were invited to participate in an online survey to assess their own attitudes, the curricular coverage of smoking, E-cigarettes, and cessation programmes.</p><p><strong>Results: </strong>Approximately 5000 students were invited; a total of 606 responses were received (12%). 8.4% currently vape (3% are current smokers). The majority (95%) reported that E-cigarette use was not covered well within their curriculum (61% stated it had not been mentioned). Despite this, 72% were aware of some health risks associated with E-cigarettes but only 6% reported they would feel confident explaining this to patients. 98% were unaware of any available cessation services.</p><p><strong>Conclusions: </strong>Practical advice and training regarding E-cigarette use and cessation is lacking across Scottish medical school curricula. Medical students lack the knowledge and confidence to explain the health consequences to patients. To enable future medical staff to deal with the rise in nicotine addiction, it is essential that medical schools improve access to information on acute and chronic health effects and cessation support. Evidence-based education and cessation programmes should be developed to ensure students feel confident in supporting future patients in attempting to quit nicotine addiction.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71125"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria F Unigarro-Martinez, Alejandra Munevar-Velandia, Ricardo Aristizabal-Duque, Carlos E Rodriguez-Martinez
{"title":"The Applicability of Existing Reference Equations for the 6-Minute Walk Test in Healthy Children and Adolescents Living in a City at a High Altitude.","authors":"Maria F Unigarro-Martinez, Alejandra Munevar-Velandia, Ricardo Aristizabal-Duque, Carlos E Rodriguez-Martinez","doi":"10.1002/ppul.71145","DOIUrl":"https://doi.org/10.1002/ppul.71145","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the applicability of existing 6MWT reference equations to healthy children and adolescents living in a high-altitude city.</p><p><strong>Methods: </strong>Healthy children aged 5 to 15 years attending two non-randomly selected schools in Bogotá were invited to participate in the study. All participants performed the 6MWT according to the European Respiratory Society/American Thoracic Society technical standards. To identify the model or set of 6MWT equations that best predicted individually measured 6MWT values in our population, we identified the narrowest limits of agreement (LOA) (mean difference between measured and predicted values ± 1.96 SD) after constructing Bland-Altman plots. We performed separate analyzes based on sex and onset of puberty, which was assumed to occur at 12 years of age for girls and 13 years of age for boys.</p><p><strong>Results: </strong>105 children and adolescents (61 girls, 58.1%) with a mean age of 10.04 years (±2.21), ranging from 6 to 15 years, were evaluated. We determined that equations derived from two different studies conducted in Brazil, de Assis, and Oliveira 6MWT equations provided the narrowest LOA in the Bland-Altman plots for the individually-measured 6MWT values for all study participants, except for the older female participants who obtained narrower LOA with the Ulrich equations.</p><p><strong>Conclusion: </strong>For the mean walked distance of the 6MWT, we have provided information on the 6MWT predictive equations that may be most appropriate for use in healthy children living in Bogota, Colombia, a city at 2640 m altitude.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71145"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Sedation on Ventilator-Induced Diaphragmatic Dysfunction in Extremely Preterm Infants.","authors":"Yusuke Hoshino, Junichi Arai, Koji Hirono, Kazushi Maruo, Rena Miura-Fuchino, Yoshiya Yukitake, Daigo Kajikawa, Tae Kamakura, Ayako Hinata, Yuki Okada, Yoshihiro Sato","doi":"10.1002/ppul.71126","DOIUrl":"10.1002/ppul.71126","url":null,"abstract":"<p><strong>Background: </strong>Ventilator-induced diaphragmatic dysfunction is associated with poor patient outcomes. However, the detailed pathophysiology and risk factors underlying the exacerbation of diaphragmatic dysfunction remain unclear. We aimed to evaluate the effect of sedation on diaphragmatic function in extremely preterm infants (EPIs) using ultrasound.</p><p><strong>Methods: </strong>A prospective observational study was conducted on 30 EPIs requiring mechanical ventilation within 6 h of birth between July 2020 and September 2023. Diaphragm ultrasound was performed to measure the end-expiratory and end-inspiratory thicknesses of the diaphragm (Tde and Tdi, respectively) and to calculate diaphragm thickening fraction (DTF) after birth and on day 1 of life. Patients receiving continuous fentanyl administration on day 1 were categorized into the sedated group, whereas those not receiving were categorized into the non-sedated group. Changes in Tde, Tdi, and DTF from day 0 to day 1 were compared between groups.</p><p><strong>Results: </strong>Baseline Tde, Tdi, and DTF did not differ between groups, and both groups showed significant reductions in Tde, Tdi, and DTF from day 0 to day 1. Analysis of covariance after controlling for gestational age and birth weight revealed that sedation significantly affected the change ratios (Tde, -0.343 vs. -0.157, p = 0.038; Tdi, -0.4 vs. -0.169, p = 0.008; DTF, -0.385 vs. -0.194, p = 0.038).</p><p><strong>Conclusion: </strong>In this pilot study, we found that sedation may affect Tde, Tdi, and DTF in ventilated EPIs, and that larger, adequately powered studies are required to validate these preliminary findings.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71126"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roxana Aznaran-Torres, Jose Nombera-Lossio, Miriam Arredondo-Nontol, Jenny Libeth Jurado-Hernández, Iván Francisco Álvarez-Orozco, Esmeralda M Rojas, Alvaro Taype-Rondan, Daniel Fernandez-Guzman
{"title":"Effects of Dupilumab in Children and Adolescents With Moderate-Severe Asthma: A Systematic Review of Clinical Trials.","authors":"Roxana Aznaran-Torres, Jose Nombera-Lossio, Miriam Arredondo-Nontol, Jenny Libeth Jurado-Hernández, Iván Francisco Álvarez-Orozco, Esmeralda M Rojas, Alvaro Taype-Rondan, Daniel Fernandez-Guzman","doi":"10.1002/ppul.71138","DOIUrl":"10.1002/ppul.71138","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the benefits and harms of Dupilumab in children and adolescents with moderate to severe asthma.</p><p><strong>Methods: </strong>We conducted a systematic search in Medline, Embase, Cochrane Controlled Register of Trials, and Clinical Trials Registries up to August 18, 2024. Whenever possible, we performed meta-analyses of the studies. The certainty of the evidence for each outcome was assessed using the GRADE methodology.</p><p><strong>Results: </strong>Seven publications from two multicenter RCTs were included. These studies included 408 children (6-11 years old) and 134 adolescents (12-17 years old). Both studies were funded by the pharmaceutical company that manufactures Dupilumab. The evidence suggests that Dupilumab probably leads to a substantial reduction in the annual rate of severe exacerbations (incidence rate ratio [IRR]: 0.46, 95% CI: 0.31-0.67; moderate certainty), particularly in children with a Th2 phenotype. Dupilumab probably improves quality of life to a clinically meaningful extent (RR: 1.18, 95% CI: 1.01-1.29; moderate certainty). However, it probably does not lead to a substantial improvement in asthma control (mean difference: -0.43, 95% CI: -0.56 to -0.30; two studies; moderate certainty; minimal-important-difference: 0.5). The frequency of serious adverse events may be similar between Dupilumab and placebo (4.8% vs. 4.5%; RR: 1.05, 95% CI: 0.41-2.68; low certainty). Finally, at 52 weeks, Dupilumab lead to an important increase in the Z-score pre-BD FEV1/FVC (RR: 1.45, 95% CI: 1.22-1.63; high certainty).</p><p><strong>Conclusion: </strong>In children and adolescents with uncontrolled moderate to severe asthma, particularly those with a Th2 inflammatory phenotype, the use of Dupilumab probably reduced the annual rate of severe exacerbations, increases both the percentage of children with good quality of life and pulmonary function parameters, with probably minimal serious adverse events.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71138"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily D Johnson, Renee D Boss, Woo Yeon Park, Khyzer B Aziz
{"title":"Time Toxicity: Quantifying Healthcare Utilization Attributable to Pediatric Home Ventilation.","authors":"Emily D Johnson, Renee D Boss, Woo Yeon Park, Khyzer B Aziz","doi":"10.1002/ppul.71081","DOIUrl":"10.1002/ppul.71081","url":null,"abstract":"<p><strong>Objective: </strong>Determine the \"time toxicity,\" or time burden patients experience when pursuing health-related interventions, of pediatric invasive home ventilation.</p><p><strong>Study design: </strong>Retrospective chart review.</p><p><strong>Methods: </strong>We identified all patients from a single neonatal intensive care unit who received a tracheostomy with/without home ventilation (T + /-HV) from 2016 to 2024. After matching the gestational week distribution of this cohort, five controls were randomly selected for each T + /-HV patient. Healthcare encounters in the electronic medical record were compared for the cohort versus controls. All encounters on a single calendar day were counted as 1 day of healthcare utilization.</p><p><strong>Results: </strong>We identified 62 patients with T + /-HV and 310 controls. Mortality was 35.5% among the T + /-HV cohort and 9% among controls. Median inpatient hospitalizations (7.0 vs. 2.0), total healthcare encounters (64.0 vs. 15.5), days of healthcare utilization (296 vs. 46), and healthcare utilization ratio (0.4 vs. 0.1) were all significantly higher for the T + /-HV cohort compared with controls. Differences were greatest in the first year of life. Among survivors in the T + /-HV cohort, decannulated patients had significantly greater healthcare utilization than those not decannulated.</p><p><strong>Conclusions: </strong>This proof-of-concept analysis quantified \"time toxicity\" for pediatric invasive home ventilation and demonstrated that neonates who receive a tracheostomy during their initial admission spent over half of all days in their first 2 years of life interacting with the healthcare system. \"Time toxicity\" could add objective information to better prepare families for what life looks like with a child using a ventilator at home.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 4","pages":"e71081"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George Shallufi, Yael Seider, Merav Zucker-Toledano, Kamal Masarweh, Michal Gur, Lea Bentur, Ronen Bar-Yoseph
{"title":"Cardiac Echocardiography Findings in Previously Healthy Hospitalized Children With Bronchiolitis - a Retrospective Study.","authors":"George Shallufi, Yael Seider, Merav Zucker-Toledano, Kamal Masarweh, Michal Gur, Lea Bentur, Ronen Bar-Yoseph","doi":"10.1002/ppul.71079","DOIUrl":"10.1002/ppul.71079","url":null,"abstract":"<p><strong>Objective: </strong>Children less than two years of age with a prolonged or severe course of bronchiolitis are usually referred for Echocardiographic evaluation during hospitalization. Our aim was to assess the yield of Echocardiography (Echo) in these children and to assess possible characteristics predicting positive Echo findings.</p><p><strong>Study design: </strong>This retrospective study over 10 years included all children under two years of age admitted with acute bronchiolitis. Data was collected using the MDClone query tool. Children with abnormal Echo findings (positive Echo) were compared to a control group (comprised of all other admitted patients with bronchiolitis, and to bronchiolitis patients referred for cardiologic evaluation and found to have normal Echo).</p><p><strong>Results: </strong>Echocardiography was performed in 251/2137 eligible patients with a clinical diagnosis of bronchiolitis. Twenty-six of 251 had abnormal findings, 20 of mild and six of moderate to severe clinical significance. Younger age at diagnosis, Arab ethnicity, higher respiratory rate, lower pH, higher pCO<sub>2</sub>, longer hospital length of stay, PICU admission and mechanical ventilation were more likely to be associated with positive Echo findings.</p><p><strong>Conclusion: </strong>Although Echocardiographic assessment of healthy infants during bronchiolitis is normal in the vast majority of children, the noninvasive, non-irradiating nature of the assessment, combined with the possible detrimental repercussions of a missed congenital cardiac anomaly, suggests performing Echocardiography during an atypical or severe course of bronchiolitis. However, larger studies are required to assess the yield of Echocardiography in bronchiolitis.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 4","pages":"e71079"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konstantina Barka, Eleni Papachatzi, Sotirios Fouzas, Gabriel Dimitriou, Theodore Dassios
{"title":"Respiratory Function in Ventilated Newborn Infants Nursed Prone and Supine.","authors":"Konstantina Barka, Eleni Papachatzi, Sotirios Fouzas, Gabriel Dimitriou, Theodore Dassios","doi":"10.1002/ppul.71075","DOIUrl":"10.1002/ppul.71075","url":null,"abstract":"<p><strong>Objectives: </strong>Prone positioning has been associated with improved oxygenation in ventilated newborn infants but the physiological basis of this improvement has not been previously studied. We aimed to test the hypothesis that respiratory function measured by composite physiological indices would be improved in the prone compared to the supine position.</p><p><strong>Study design: </strong>Prospective observational study of ventilated newborns in a tertiary neonatal unit studied prone and supine at random order.</p><p><strong>Methodology: </strong>The ventilation to perfusion ratio (V<sub>A</sub>/Q) and right to left shunt were non-invasively calculated using the oxyhemoglobin dissociation curve method. The gradient of the arterial to end tidal carbon dioxide (PaCO<sub>2</sub> - EtCO<sub>2</sub> gradient) was calculated to describe changes in the alveolar dead space.</p><p><strong>Results: </strong>Forty-six (26 male) infants with a median (IQR) gestational age of 34.8 (33.1-36.3) weeks and birth weight of 2.34 (1.77-2.87) kg were studied after 5 (2-10) hours of invasive ventilation. The V<sub>A</sub>/Q was significantly higher in the prone position [0.57 (0.52-0.63)] compared to supine [0.53 (0.46-0.62), p = 0.001]. Right to left shunt was significantly lower in prone [7 (0-12) %] compared to supine [9 (1-16) %, p = 0.003]. The PaCO<sub>2</sub> - EtCO<sub>2</sub> gradient was significantly lower in prone [6.3 (3.8-8.4) mmHg] compared to supine [12.1 (7.1-16.0) mmHg].</p><p><strong>Conclusions: </strong>The prone position in ventilated neonates was associated with improved ventilation to perfusion matching and lower intrapulmonary shunting and alveolar dead space compared to supine.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 4","pages":"e71075"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}