Pediatric Pulmonology最新文献

{"title":"Pulmonary Embolization in Pediatric Patients: Single-Center Experience.","authors":"Nilgun Kula, Tugba Sismanlar Eyuboglu, Mehmet Koray Akkan, Oznur Leman Boyunaga, Ahmet Baran Onal, Ayse Tana Aslan","doi":"10.1002/ppul.71131","DOIUrl":"https://doi.org/10.1002/ppul.71131","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71131"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Gua Sha Therapy Combined With Acupoint Application on Chronic Cough in Pediatrics.","authors":"Danxia Ni, Liyun Zhong, Xinping Liu, Wenjing Lai, Jingyi Mai, Weiyi Dai, Meifeng Xie, Lifang Lei","doi":"10.1002/ppul.71065","DOIUrl":"https://doi.org/10.1002/ppul.71065","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of gua sha therapy combined with acupoint application on pediatric chronic cough.</p><p><strong>Methods: </strong>The convenience sampling method was used to enroll 200 children with chronic cough from a hospital in Guangzhou between April 2023 and October 2024 in this study. These children were divided into a conventional control group, an acupoint patch group, a gua sha group, and a gua sha therapy combined with an acupoint patch treatment group (combined group). The intervention measures included conventional medication treatment, gua sha, and acupoint application. There were 50 patients in each group, and cough symptom scores, life quality questionnaire (Leicester Cough Questionnaire), and simulated visual pain scores (visual analog scale [VAS]) were collected for comparison.</p><p><strong>Results: </strong>Compared with the pretreatment period, daytime and nighttime scores in all four groups were reduced (p < 0.05). After treatment, the pairwise comparisons showed the following descending order: control group > acupoint application group = gua sha group > combined group (p < 0.05). Quality of life scores increased, whereas VAS scores decreased in all four groups compared with pretreatment (p < 0.05). After treatment, the pairwise comparisons revealed that the quality of life scores, in descending order, were as follows: combined group > acupoint application group = gua sha group > control group (p < 0.05), and the VAS scores, in descending order, were as follows: control group > acupoint application group = gua sha group > combined group (p < 0.05). No significant adverse reactions occurred during the treatment period in all four groups.</p><p><strong>Conclusion: </strong>Gua sha therapy and acupoint application have good clinical efficacy on pediatric chronic cough, and the combination of the two can further improve the efficacy.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71065"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding the Need: A Study on Food Security Among People With Cystic Fibrosis in Turkey.","authors":"Damla Kocaman, Ceren Ayça Yıldız, Neval Metin Çakar, Burcu Uzunoğlu, Gamze Taştan, Mine Yüksel Kalyoncu, Merve Selçuk Balcı, Şeyda Karabulut, Pınar Ergenekon, Yasemin Gökdemir, Ela Erdem Eralp, Fazilet Karakoç, Bülent Karadağ","doi":"10.1002/ppul.71101","DOIUrl":"https://doi.org/10.1002/ppul.71101","url":null,"abstract":"<p><strong>Background: </strong>Cystic fibrosis (CF) is a genetic disorder that necessitates high-calorie, protein-rich diets, leading to nutritional deficiencies. Food insecurity (FI) poses a significant challenge for people with CF (pwCF), impacting their ability to maintain the necessary dietary intake. This study aims to explore FI and dietary patterns among pwCF in Turkey.</p><p><strong>Methods: </strong>A cross-sectional study involving 290 pwCF from the Marmara University Selim Çöremen Cystic Fibrosis Center was conducted between April 2023 and February 2024. The \"US Household Food Security Survey Module\" and the \"Your Current Life Situation\" survey were used to assess FI and socioeconomic status among the participants. Nutritional data, including BMI, FEV1 values, and dietary intake, were recorded.</p><p><strong>Results: </strong>Among the participants, 52.7% were female, with a mean age of 13.3 ± 8.1 years. FI was detected in 46.8% of pwCF, with 18% facing very low food security. Higher income levels were associated with better food security (p = 0.008). Nutritional inadequacies were observed even among food-secure individuals, particularly in the consumption of legumes, nuts, and fish. BMI and BMI percentile values were significantly lower in the very low FS group compared to the high FS group (p = 0.03 and p = 0.02, respectively).</p><p><strong>Conclusion: </strong>Ensuring adequate nutrition and calorie intake is crucial for pwCF. Our study highlights significant FI among pwCF in Turkey, with income levels influencing food security status. Nutritional inadequacies persist even among those classified as food secure. Based on these findings, targeted nutritional support will be provided to those in need to improve overall health and well-being.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71101"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm Function in Very Preterm Infants at 36 Weeks' Postmenstrual Age.","authors":"Benjamin Stoecklin, Zeena Al-Obaidi, Jenny Svedenkrans, Raffaele Dellacà, J Jane Pillow","doi":"10.1002/ppul.71121","DOIUrl":"10.1002/ppul.71121","url":null,"abstract":"<p><strong>Objectives: </strong>Understand how bronchopulmonary dysplasia (BPD) and antenatal and postnatal factors influence diaphragmatic functional effectiveness in very preterm infants.</p><p><strong>Working hypothesis: </strong>Diaphragmatic functional effectiveness during spontaneous breathing is impaired in infants with BPD. Moreover, diaphragmatic functional effectiveness is influenced by adverse antenatal and postnatal factors.</p><p><strong>Methodology: </strong>Diaphragmatic functional effectiveness was assessed in a single-centre, prospective observational study in preterm infants. Transdiaphragmatic pressure (Pdi) and respiratory flow were measured during quiet sleep at 36 weeks' postmenstrual age (PMA). Pdi was normalized to tidal volume (Pdi/V_T). Diaphragmatic work of breathing per minute was calculated from the inspiratory pressure time integral (PTIdi) and respiratory rate. Factors predictive for each outcome were identified from multivariable linear regression.</p><p><strong>Results: </strong>Very preterm infants (n = 182) were measured at a median (IQR) 35.6 (1.3) weeks' PMA. Infants with BPD had a lower Pdi/V_T (p = 0.007) and lower PTIdi·min^-1 (p = 0.022) but higher minute ventilation (p = 0.032) and similar respiratory rates (p = 0.419) compared to infants without BPD. Birthweight Z score (R² = 0.08, p < 0.001) and BPD (R² = 0.04, p = 0.022) were independent negative predictors for Pdi/V_T while gestational age (R² = 0.04, p = 0.01) and average early postnatal energy intake (R² = 0.03, p = 0.026) were independent positive predictors for PTIdi·min^-1 on multivariable analysis. Chorioamnionitis and duration of mechanical ventilation did not contribute to the final model.</p><p><strong>Conclusions: </strong>Contrary to our hypothesis, diaphragm functional effectiveness appears improved in infants with BPD. We speculate this finding may reflect an adaptive process, or alternatively indicate an increased recruitment of accessory muscles to achieve required ventilation in BPD infants. Adverse antenatal and postnatal factors only explain a small proportion of variance in diaphragm effectiveness.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71121"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upcoming events of interest.","authors":"","doi":"10.1002/ppul.71119","DOIUrl":"https://doi.org/10.1002/ppul.71119","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71119"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cause of Interstitial Lung Disease in Infancy: CCR2 Gene.","authors":"Meltem Kürtül Çakar, Salih Uytun, Murat Yasin Gençoğlu, Şule Selin Akyan Soydaş, Satı Özkan Tabakçı, Işıl Bilgiç, Gamze Akça Dinç, Ayyüce Ünlü, Hande Yetişgin, Çelebi Yıldırım, Gökçen Dilşa Tuğcu, Dilber Ademhan Tural, Sanem Eryılmaz Polat, Güzin Cinel","doi":"10.1002/ppul.71116","DOIUrl":"https://doi.org/10.1002/ppul.71116","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71116"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible Bronchoscopy in Neonates With Congenital Diaphragmatic Hernia.","authors":"Judith Leyens, Lukas Schroeder, Carmen Salatsch, Joachim Schmitt, Hemmen Sabir, Andreas Mueller, Florian Kipfmueller, Till Dresbach","doi":"10.1002/ppul.71128","DOIUrl":"10.1002/ppul.71128","url":null,"abstract":"<p><strong>Background: </strong>Flexible bronchoscopy (FB) may facilitate ECMO and ventilator weaning through diagnosing airway anomalies and removal of mucous plugs in the critically-ill pediatric population. Only few studies on FB in critically-ill neonates exist, and even fewer focus on neonates with congenital diaphragmatic hernia (CDH) requiring extracorporal membrane oxygenation (ECMO). This study aims to evaluate the risk and benefit of FB in infants with CDH.</p><p><strong>Methods: </strong>A retrospective review of CDH infants treated at a specialized single center between October 2019 and August 2024 was conducted. Baseline characteristics were compared between patients with and without FB. Procedural indications, findings and complications were analyzed.</p><p><strong>Results: </strong>A total of 142 newborns were analyzed. Infants requiring FB (n = 29, 20.4%) exhibited an overall higher disease burden (lower observed-to-expected lung-to-head ratio [p < 0.001), liver herniation (p = 0.002), ECMO (p < 0.001), defect size (p = 0.042), congenital anomalies (p = 0.019), heart defects (p = 0.010)]. The primary indications for the total 56 FBs were prolonged weaning and pulmonary hemorrhage. The most common complication was self-resolved hypoxemia (16.1%). Bronchial casts were found in 31.6%. Tracheo-/bronchomalacia was diagnosed in 16 infants (55.2%). Postprocedural chest Xrays were mostly unchanged (61.9%). A trend to achieve higher tidal volumes post-FB (p = 0.090) with similar peak inspiratory pressures (p = 0.917) was noted.</p><p><strong>Conclusions: </strong>In critically-ill neonates with CDH, FB was safe, with a high diagnostic and potential therapeutic yield. The necessity for FB may be an additional indicator of CDH disease severity. Further research is needed to establish uniform assessment metrics and explore other modalities such as electrical impedance tomography or lung ultrasound in the context of FB.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71128"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Findings in Children With Colchicine-Resistant Familial Mediterranean Fever.","authors":"Evrim Hepkaya, Nebahat Zeynep Özaslan, Törehan Özer, Betül Öksel, Yonca Anık, Nihal Şahin, Hafize Emine Sönmez","doi":"10.1002/ppul.71136","DOIUrl":"10.1002/ppul.71136","url":null,"abstract":"<p><strong>Background: </strong>Approximately 5%-10% of Familial Mediterranean Fever (FMF) patients fail to achieve full disease control despite adequate colchicine therapy and these patients may be vulnerable for lung involvement.</p><p><strong>Objectives: </strong>This study aimed to examine pulmonary findings on thoracic computerized tomography (CT) in children with colchicine-resistant FMF (crFMF), and their correlation with clinical characteristics regarding pulmonary involvement in childhood FMF is not well understood, and there is a lack of research specifically evaluating crFMF cases.</p><p><strong>Methods: </strong>This cross-sectional study investigated pulmonary findings in 31 patients diagnosed with crFMF, focusing on thoracic CT scan findings and respiratory symptoms such as dry cough, shortness of breath, and exercise intolerance. The study further incorporated spirometry evaluations to assess pulmonary functions.</p><p><strong>Results: </strong>Of the patients, 29.1% had normal thoracic CT scans, whereas 70.9% showed abnormalities, with nodules being the most common finding (61.2%). One patient demonstrated subpleural honeycombing and bilateral ground-glass opacities, indicating FMF-related interstitial lung disease (ILD). Chest pain was the predominant symptom during the attacks (70.9%), while shortness of breath persisted most frequently. While 32% of the patients had abnormal values of spirometry at postattack period, the rate was 14.2% when they were clinically stable. There was an increase at mean forced expiratory flow at 25%-75% of FVC (FEF25-75) at the stable phase. (83.1 ± 19.2 vs. 92.2 ± 21.6, p = 0.05). No significant differences in CT findings were noted between genotypes and ISSF scores.</p><p><strong>Conclusions: </strong>The study highlights a high prevalence of radiological findings in patients with crFMF; notably, a case with findings suggestive of FMF-related interstitial lung involvement was defined. Respiratory symptoms and abnormal values at spirometry were frequently accompanied by FMF attacks. These findings underscore the need for respiratory evaluation thoroughly in patients with crFMF to detect subclinical or overt pulmonary involvement and to guide appropriate management strategies.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71136"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crushing Elexacaftor/Tezacaftor/Ivacaftor Oral Granules for Gastrostomy Tube Administration.","authors":"Alexander S Kim, Elizabeth Autry","doi":"10.1002/ppul.71124","DOIUrl":"https://doi.org/10.1002/ppul.71124","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71124"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Interstitial Lung Diseases: Lessons Learned From 15-Year Observation at a Polish Referral Center.","authors":"Honorata Marczak, Katarzyna Krenke, Katarzyna Solarska-Rydz, Joanna Lange, Teresa Bielecka, Marek Kulus","doi":"10.1002/ppul.71112","DOIUrl":"https://doi.org/10.1002/ppul.71112","url":null,"abstract":"<p><strong>Background: </strong>Childhood interstitial lung diseases (chILD) are rare, chronic lung diseases characterized by symptoms such as tachypnea, dyspnea, hypoxemia, crackles, and diffuse parenchymal abnormalities on chest imaging.</p><p><strong>Objective: </strong>To evaluate the etiologic spectrum, clinical presentation, management, and outcomes of chILD at a Polish referral center.</p><p><strong>Methods: </strong>We retrospectively reviewed data from patients (0-18 years) diagnosed with chILD, admitted to the Department of Pediatric Pulmonology and Allergy, Medical University of Warsaw, from June 2009 to February 2024, classified according to the chILD-EU categorization system.</p><p><strong>Results: </strong>A total of 275 patients (65.5% male) were included, with a median age at diagnosis of 13 months (range: 1-221). Persistent tachypnea of infancy (PTI)/neuroendocrine cell hyperplasia of infancy (NEHI) was the most common diagnosis (52.4%), followed by disorders related to systemic diseases (11.3%) and related to exposures (10.2%). 13.8% of diseases remained undefined. The predominant symptoms included crackles (81.5%), dyspnea (72.7%) and tachypnea (68.3%). All children underwent chest computed tomography. Bronchoscopy, genetic testing, and lung biopsy were performed in 46.2%, 34.9%, and 21.4% of cases, respectively. Most children (92.7%) received some form of treatment, including inhaled bronchodilators/steroids (68.8%), systemic steroids (26.5%), long-term macrolides (16.3%), and immunosuppressants (11.6%). Oxygen supplementation and nutritional support were required in 50.5% and 29.8% of patients, respectively. At a median follow-up of 31.5 months, 92.9% of patients achieved clinical improvement or stabilization, and 6.2% deteriorated, including seven deaths. The 5-year survival rate was 95.66%.</p><p><strong>Conclusion: </strong>This study highlights the significant diversity within chILD, with PTI/NEHI being the most common condition.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 5","pages":"e71112"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}