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Pediatric Pulmonology最新文献

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The bidirectional interplay of obstructive sleep apnea and viral respiratory infections in children: A novel opportunity for primary prevention. 儿童阻塞性睡眠呼吸暂停与病毒性呼吸道感染的双向相互作用：初级预防的新机遇。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-04 DOI: 10.1002/ppul.27314
Gustavo Nino, Elizabeth Chorvinsky, Surajit Bhattacharya, Maria J Gutierrez
{"title":"The bidirectional interplay of obstructive sleep apnea and viral respiratory infections in children: A novel opportunity for primary prevention.","authors":"Gustavo Nino, Elizabeth Chorvinsky, Surajit Bhattacharya, Maria J Gutierrez","doi":"10.1002/ppul.27314","DOIUrl":"https://doi.org/10.1002/ppul.27314","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) and viral respiratory infections are highly prevalent conditions in children and a major cause of respiratory morbidity in this age group. Severe viral respiratory infections are a known risk factor for pediatric OSA, which is primarily caused by hypertrophy of upper airway lymphoid tissues (adenoids and tonsils). This review examines recent progress in understanding early-life development of lymphoid tissues in the human upper airway, with a particular focus on how respiratory viruses may influence this process and contribute to OSA pathogenesis. It also explores the bidirectional relationship between OSA and severe viral infections, highlighting the need for ongoing monitoring and novel primary prevention strategies to address these interconnected conditions.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges in the care of cystic fibrosis in low-to-middle income countries. 中低收入国家在治疗囊性纤维化方面面临的挑战。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27294
Sushil Kr Kabra
{"title":"Challenges in the care of cystic fibrosis in low-to-middle income countries.","authors":"Sushil Kr Kabra","doi":"10.1002/ppul.27294","DOIUrl":"https://doi.org/10.1002/ppul.27294","url":null,"abstract":"<p><p>Till few years ago cystic fibrosis (CF) was considered to be exclusively disease affecting Caucasian population. More recently CF has been reported from all over the world from different ethnic background. CF is an emerging illness in other parts of world (India with 1:2200 to 1:40,000 live birth). In low- and middle-income countries (LMICs) diagnosis of CF is missed due to ignorance and nonavailability of diagnostic tests. Diagnosis can be made using clinical features and basic lab tests. As of now there is no cure, but supportive care improved survival. However, medicines used in higher income countries are very expensive and not accessible to children with CF in LMICs. Cystic fibrosis transmembrane regulators modulators have emerged as significant advances in management. These are very expensive and beyond the reach of patients in LMICs. CF Fraternity in developed countries should work towards training of personnel and possibly making medications available in LMICs.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age. 综合肺功能分析确定了一岁左右前早产儿的主要阻塞表型。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27287
Elkie S Stein, Avigdor Hevroni, Mor Zarfati, Ira Erlichman, Laurice Boursheh, Alex Gileles-Hillel
{"title":"Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age.","authors":"Elkie S Stein, Avigdor Hevroni, Mor Zarfati, Ira Erlichman, Laurice Boursheh, Alex Gileles-Hillel","doi":"10.1002/ppul.27287","DOIUrl":"https://doi.org/10.1002/ppul.27287","url":null,"abstract":"<p><strong>Background: </strong>Preterm infants suffer from significant respiratory morbidity during the first years of life, but the underlying lung pathophysiology is not fully understood. This study aimed to comprehensively characterize the pulmonary functions of preterm infants using full infant pulmonary function testing (iPFT).</p><p><strong>Methods: </strong>Between 2008 and 2019, we recruited 150 infants (M<sub>age</sub> 10.5 ± 6 months) of them 104 preterm infants (median gestational age [GA] = 34 weeks (28-36), n = 23 with bronchopulmonary disease [BPD]) and 46 controls born at term. We compared full iPFT parameters of preterm infants to a control group of term infants. Subanalysis included a comparison of preterm infants by BPD status and GA.</p><p><strong>Results: </strong>Preterm infants had impaired flow parameters, reduced compliance, and air trapping, compared to term infants. Only 15% (n = 14) of the preterm group had normal iPFT, compared to 69% (n = 31) of the term group. The majority of the impaired iPFT in preterm infants were obstructive and 72% (n = 69) had no response to bronchodilators. Reduced maximal flow at the functional residual capacity point (V'<sub>max</sub>FRC) was associated with low birth weight and GA. There were no major differences between preterm infants with or without BPD.</p><p><strong>Conclusions: </strong>Preterm infants in the first year of life, demonstrated a high prevalence of obstructive iPFT unresponsive to bronchodilators. BPD status did not add to the degree of pulmonary impairment. These data reveal an airway-predominant pathology of the modern-era prematurity-associated lung disease. Pulmonary function screening tests at an early age may be of value in determining the presence and severity of lung disease in the preterm population. V'<sub>max</sub>FRC may provide a good assessment of pulmonary impairment in preterm infants.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating genomics as clinical biomarkers in pediatric pulmonology. 整合基因组学作为儿科肺病学的临床生物标记物。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27308
Erick Forno
{"title":"Integrating genomics as clinical biomarkers in pediatric pulmonology.","authors":"Erick Forno","doi":"10.1002/ppul.27308","DOIUrl":"https://doi.org/10.1002/ppul.27308","url":null,"abstract":"<p><p>Respiratory diseases often result from complex interactions between an individual's genetic predisposition and their exposure to various environmental and other risk factors. Here we will briefly review how various types of \"omics\", particularly epigenomics and transcriptomics, hold promise for translation into clinical biomarkers in pediatric pulmonary medicine, using asthma and cystic fibrosis as examples.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term respiratory consequences of prematurity. 早产儿呼吸系统的长期后果。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27304
Mariëlle W Pijnenburg
{"title":"Long-term respiratory consequences of prematurity.","authors":"Mariëlle W Pijnenburg","doi":"10.1002/ppul.27304","DOIUrl":"https://doi.org/10.1002/ppul.27304","url":null,"abstract":"<p><p>Approximately 10% of all children worldwide are born preterm and respiratory consequences are amongst the most common sequelae of preterm birth. Except for a higher prevalence of respiratory symptoms and hospital admissions, preterm birth is associated with lower lung function that may track into adulthood. Lung function impairment is not restricted to extreme or very preterm-born subjects as also children born moderate-late preterm have lower Z-scores for lung function. Given the heterogeneity of prematurity-associated lung disease, phenotype-based, multidisciplinary management is needed to improve respiratory health in preterm-born subjects.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostaglandin E1 in neonatal pulmonary hypertension: Need for randomized trials based on physiology-Response. 前列腺素 E1 在新生儿肺动脉高压中的应用：需要基于生理学的随机试验--回应。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27312
Stephanie M Tsoi, Roberta L Keller
{"title":"Prostaglandin E1 in neonatal pulmonary hypertension: Need for randomized trials based on physiology-Response.","authors":"Stephanie M Tsoi, Roberta L Keller","doi":"10.1002/ppul.27312","DOIUrl":"https://doi.org/10.1002/ppul.27312","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tracing the path from preschool wheezing to asthma. 追溯从学龄前喘息到哮喘的过程
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27305
Ellen Kong, Darije Custovic, Adnan Custovic
{"title":"Tracing the path from preschool wheezing to asthma.","authors":"Ellen Kong, Darije Custovic, Adnan Custovic","doi":"10.1002/ppul.27305","DOIUrl":"https://doi.org/10.1002/ppul.27305","url":null,"abstract":"<p><p>This short review illustrates, using two recent studies, the potential and challenges of using machine learning methods to identify phenotypes of wheezing and asthma from childhood onwards.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep-disordered breathing-year in review 2024. 睡眠呼吸障碍 2024 年回顾。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27303
Jean-Paul Praud
{"title":"Sleep-disordered breathing-year in review 2024.","authors":"Jean-Paul Praud","doi":"10.1002/ppul.27303","DOIUrl":"https://doi.org/10.1002/ppul.27303","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indoor air pollution and its impact on the lungs. 室内空气污染及其对肺部的影响。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27281
Peter D Sly
{"title":"Indoor air pollution and its impact on the lungs.","authors":"Peter D Sly","doi":"10.1002/ppul.27281","DOIUrl":"https://doi.org/10.1002/ppul.27281","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childhood CBD exposure and lung function: Concerns and future directions. 儿童接触 CBD 与肺功能：关注问题和未来方向。
IF 2.7 3区 医学
Pediatric Pulmonology Pub Date : 2024-10-03 DOI: 10.1002/ppul.27271
Lien-Chung Wei, Kuen-Hong Wu
{"title":"Childhood CBD exposure and lung function: Concerns and future directions.","authors":"Lien-Chung Wei, Kuen-Hong Wu","doi":"10.1002/ppul.27271","DOIUrl":"https://doi.org/10.1002/ppul.27271","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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