Pediatric Pulmonology最新文献

{"title":"'The Effect of Iron Deficiency Anemia on Emergency Department Admission in Asthmatic Children'.","authors":"Ahmet Selmanoglu, Şule Büyük Yaytokgil, Ayça Koca Yozgat, Müge Toyran, Emine Dibek Mısırlıoglu, Namık Yaşar Özbek, Ersoy Civelek","doi":"10.1002/ppul.71163","DOIUrl":"https://doi.org/10.1002/ppul.71163","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71163"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innominate Artery Compression Syndrome in an Infant With Acyanotic Congenital Heart Disease.","authors":"Resham Singh, Vineeta Ojha, Nabeel Valappil Faisal, Sanjeev Kumar","doi":"10.1002/ppul.71141","DOIUrl":"https://doi.org/10.1002/ppul.71141","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71141"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HHHFNC Versus NIPPV Delivered by Long Narrow Cannula in Preterm Infants: Randomized Noninferiority Trial.","authors":"Ayala Gover, Tatiana Smolkin, Michal Molad, Karen Lavie-Nevo, Adir Iofe, Rasha Zoabi-Safadi, Arina Toropine, Rawnak Nazem Saab, Dan Waisman, Avi Rotschild, Amir Kugelman, Arieh Riskin","doi":"10.1002/ppul.71167","DOIUrl":"10.1002/ppul.71167","url":null,"abstract":"<p><strong>Background: </strong>Heated humidified high flow (HHHFNC) and nasal intermittent positive pressure ventilation (NIPPV) delivered by cannula with long and narrow tubing (CLNT) are increasingly used in preterm infants for providing noninvasive respiratory support, due to their high comfort level and minimal nasal trauma. Despite their widespread use, no randomized controlled trial has been conducted so far.</p><p><strong>Objective: </strong>Determine whether HHHFNC is non-inferior to CLNT-NIPPV in providing respiratory support for preterm infants.</p><p><strong>Study design: </strong>An unblinded, randomized controlled, non-inferiority multicenter trial.</p><p><strong>Methodology: </strong>Preterm infants randomized to either HHHFNC or CLNT-NIPPV. Infants born > 28 weeks of gestation were eligible to enter the study either as primary treatment after birth or post-extubation. Infants born ≤ 28 weeks of gestation were only eligible post-extubation. The primary outcome was treatment failure within 7 days.</p><p><strong>Results: </strong>One hundred and thirty infants were enrolled in the study; 65 in each group. Most (82%) were > 28 weeks, and primary treatment (73%). HHHFNC was non-inferior to CLNT-NIPPV in the primary outcome which occurred in 12.3% compared to 23.0% of the infants, respectively (risk difference (RD) -10.77%, 95% CI of RD -23.7 to 2.22 [within the non-inferiority margin], χ²p = 0.168). HHHFNC was associated with significantly less nasal trauma compared to CLNT-NIPPV but with longer time on the allocated respiratory support. No significant differences were found between the groups in secondary respiratory and neonatal outcomes.</p><p><strong>Conclusions: </strong>In this study of preterm infants mostly > 28 weeks of gestation, HHHFNC was non-inferior to CLNT-NIPPV in providing respiratory support, and caused less nasal trauma.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71167"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the COVID-19 Pandemic on Healthcare Utilization Rates and Obesity in Urban Minority Children With High Asthma Disease Burden: A Retrospective Cohort Study.","authors":"Ye Sun, Zoya Treyster, Deepa Rastogi, Laura A Conrad","doi":"10.1002/ppul.71175","DOIUrl":"10.1002/ppul.71175","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic caused dramatic changes in daily routines, healthcare access, and utilization in children with asthma, particularly urban minority children with poorly controlled asthma.</p><p><strong>Objectives: </strong>In this study, we aimed to elucidate changes in healthcare utilization, lung function, and weight as a result of the COVID-19 \"shutdown\" in patients followed at the Pediatric Asthma Center at the Children's Hospital at Montefiore.</p><p><strong>Study design: </strong>We conducted a retrospective cohort study including children aged 2-21 with physician-diagnosed persistent asthma. We compared healthcare utilization, lung function, asthma control, and weight changes before and after the COVID-19 lockdown (March 16, 2020 to June 1, 2020).</p><p><strong>Results: </strong>This study included 101 children (61% Hispanic, 28% Black) with an average age of 9.2 (±4.7) years. There was a statistically significant decrease in hospitalization rates, emergency department visits, oral steroid use, urgent care visits and office visits pre- and post-COVID-19 shutdown, which was associated with improvement in asthma control (p < 0.001) but there was no significant improvement in lung function. Obesity rates increased overall from 29.7% to 43.9%, but weight gain did not differ based on asthma severity. Weight gain was disproportionally higher in a small sub-population of patients who needed step-up therapy.</p><p><strong>Conclusion: </strong>Inner-city children with high asthma morbidity saw a significant reduction in healthcare utilization during the COVID-19 pandemic, with improved asthma control but no change in spirometry results. Despite an increase in obesity rates overall, weight changes did not differ across asthma severities, suggesting increase in obesity was not mediated by asthma severity.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71175"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upcoming events of interest.","authors":"","doi":"10.1002/ppul.71158","DOIUrl":"https://doi.org/10.1002/ppul.71158","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71158"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Treatment of Cicatricial Airway Stenosis via Flexible Bronchoscopic Intervention.","authors":"Hujun Wu, Xiaofen Tao, Fang Jin, Yanfen Lin, Langfang Tang, Lei Wu, Xiling Wu","doi":"10.1002/ppul.71169","DOIUrl":"10.1002/ppul.71169","url":null,"abstract":"","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71169"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Elexacaftor/Tezacaftor/Ivacaftor on Fecal Elastase-1 in Children With Cystic Fibrosis.","authors":"Senthilkumar Sankararaman, Leesa Prunty, Catherine Pamer, Aravind Thavamani, Erica Roesch, Teresa Schindler","doi":"10.1002/ppul.71156","DOIUrl":"10.1002/ppul.71156","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have documented improvement in pancreatic status after ivacaftor and lumacaftor/ivacaftor in a small number of patients with cystic fibrosis (CF). There is paucity of data with similar improvement after initiation of elexacaftor/tezacaftor/ivacaftor (ETI).</p><p><strong>Methods: </strong>In this cross-sectional study, we retrospectively reviewed the change in fecal elastase-1 (FE-1) at least 6 months after initiation of ETI in children less than 12 years of age. Children who demonstrated a change in FE-1 of ≥ 100 µg/g from the baseline after ETI therapy (post-ETI FE-1 minus pre-ETI FE-1) were termed as responders and those with a change in FE-1 < 100 µg/g post-ETI (or no change in FE-1) were termed as nonresponders.</p><p><strong>Results: </strong>Thirty-five children had post-ETI FE-1 value at least 6 months after its initiation and were included for final review. The mean change (±SD) in FE-1 post-ETI from the baseline in the entire cohort was 47.2 ± 89.5. Seven children had a change in FE-1 of ≥ 100 µg/g or more post-ETI (responders). Two of these seven patients had a change in FE-1 of ≥ 200 µg/g post-ETI. Twenty-three had no change or change < 100 µg/g post-ETI (nonresponders). Another five children who did not have a baseline FE-1 and had post-ETI FE-1 < 10 µg/g were also added to the nonresponders cohort increasing the total number to 28. The pre- and post-ETI body mass index was significantly higher in the responder group compared to the nonresponders.</p><p><strong>Conclusion: </strong>In our cohort of 35 children, 7 (20%) were noted to have a positive change in FE-1 from the baseline value of ≥ 100 µg/g post-ETI. Further prospective multicenter studies will help identify predictive factors associated with improvement in FE-1 after initiation of CFTR-directed modulator therapies.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71156"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Inhaled Tobramycin for Pseudomonas Eradication in People With Cystic Fibrosis Less Than 1 Year of Age.","authors":"Daniel Riggsbee, Rebecca S Pettit","doi":"10.1002/ppul.71162","DOIUrl":"https://doi.org/10.1002/ppul.71162","url":null,"abstract":"<p><strong>Background: </strong>Inhaled tobramycin solution is recommended for eradication treatment of Pseudomonas aeruginosa (PA) infections in people with cystic fibrosis (PwCF). However, there is limited information on the safety of inhaled tobramycin in PwCF less than 1 year old and no studies primarily analyzing the safety of the 300 mg inhaled solution. The objective of this study was to compare the incidence of adverse drug events (ADE) of inhaled tobramycin in PwCF less than 1 year old to PwCF ages 1 year to 18 years old.</p><p><strong>Methods: </strong>This retrospective analysis evaluated the incidence of inhaled tobramycin ADEs in PwCF ages 14 days to 18 years with CF between January 01, 2008 to January 01, 2022. PwCF less than 1 year of age (infant group) were matched based on genotype in a 1:3 ratio with a PwCF at least a year old to 18 year-old (children group).</p><p><strong>Results: </strong>Forty-eight patients were included (infant group: 12, children group: 36). Median (IQR) age was 0.48 years (0.2-0.7) and 4.7 years (2.3-10) in infant group and children group respectively (p < 0.05). There were 5 (41.7%) ADE in the infant group and 3 (8.3%) in the children group (p = 0.016). When cough was removed there was no significant difference between the two groups [2 (16.7%) vs. 1 (2.7%), p = 0.15]. There was no difference in treatment failure [3 (25%) vs. 7 (19.4%), p = 0.68].</p><p><strong>Conclusions: </strong>This study found a higher incidence of inhaled tobramycin ADE in infants compared to children. These results show a low risk of ADE outside of cough, indicating that inhaled tobramycin may be safely used in this age group.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71162"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life After Pediatric Lung Transplantation.","authors":"Nicole Martin, Edith Nachbaur, Zsolt Szépfalusi, Dóra Krikovsky, Lajos Kovács, Clemens Aigner, Konrad Hoetzenecker, Alberto Benazzo, Peter Jaksch, Alexandra Graf, Saskia Gruber","doi":"10.1002/ppul.71157","DOIUrl":"10.1002/ppul.71157","url":null,"abstract":"<p><strong>Background: </strong>Pediatric lung transplantation is a therapeutic option for children and adolescents with end-stage lung disease. While it offers a chance to extend survival and improve physical health, the impact on health-related quality of life (HRQOL) remains understudied.</p><p><strong>Methods: </strong>This observational study aimed to assess HRQOL in pediatric lung transplant recipients using the EuroQol questionnaire and additional self-designed questions about school, employment, and housing situations. We compared the results to those in children and adolescents with end-stage lung disease and investigated possible influencing determinants. Patients were included during routine clinical visits, starting at least 2 months post-transplant. Data collection was from November 2016 to January 2023.</p><p><strong>Results: </strong>The study included 29 pediatric lung transplant recipients aged between 4 and 17 years at the time of first transplantation. Our findings show a good HRQOL after pediatric lung transplantation with a median EuroQol-Score of 1.0, representing the best possible EuroQol-Score, and a median visual analog scale (VAS) score of 93 out of 100. Most patients were engaged in employment or education, and they typically lived with their parents. HRQOL was superior to that of pre-transplant patients with end-stage lung disease, suggesting a quality of life improvement by lung transplantation. The presence of chronic lung allograft dysfunction (CLAD), a lower age at transplantation, and a longer time since transplantation were associated with lower HRQOL scores.</p><p><strong>Conclusion: </strong>This study underscores the generally favorable HRQOL experienced by pediatric lung transplant recipients.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71157"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fueling Health: Overcoming Food Barriers in Cystic Fibrosis Care.","authors":"Brittany A Wright, Kayla C Godfrey, Erica E Gryp, Nichole M Harklau, Leah B Colsch","doi":"10.1002/ppul.71177","DOIUrl":"10.1002/ppul.71177","url":null,"abstract":"<p><strong>Background: </strong>Food insecurity is increasing in prevalence throughout the general population and has been noted to substantially exist within the cystic fibrosis (CF) community as well. Nutritional grant programs are in place to provide additional support to people with cystic fibrosis (PwCF). This study was designed to determine the current usage rate of nutritional grant funding as well as clinical outcomes such as body mass index (BMI). We aim to describe our CF center's enrollment and usage of privately funded nutritional grants and explore potential correlations to nutrition clinical outcomes.</p><p><strong>Methods: </strong>A single center retrospective chart review of the electronic health records (EHR) to collect requested data points was completed for all PwCF seen at that center between the dates of March 1, 2017 and February 29, 2024.</p><p><strong>Results: </strong>Two hundred and nineteen individuals met inclusion criteria. Over the course of the study period, the total number of PwCF enrolled in supplemental nutritional grant program(s) and amount of grant utilization increased steadily from 9% enrolled with 17% utilization in 2017 to 27% enrolled with 44% utilization in 2022, respectively. The percentage of PwCF with a BMI below Cystic Fibrosis Foundation (CFF) recommended goals also decreased over the course of the study period from 39% in 2017 to 31% in 2022.</p><p><strong>Conclusions: </strong>We conclude that the results of our study support continued efforts to identify and remediate the presence of food insecurity within the CF community.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 6","pages":"e71177"},"PeriodicalIF":2.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}