{"title":"鼻高流量治疗持续时间对极早产儿呼吸结局的影响：倾向评分分析。","authors":"Emanuela Zannin, Camilla Rigotti, Giulia Dognini, Danila Azzolina, Maria Luisa Ventura","doi":"10.1002/ppul.71313","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Nasal high flow therapy (nHFT) is being used earlier and for longer than in the past as an alternative to nasal Continuous Positive Airway Pressure (nCPAP) for preterm neonates. The aim of the present study was to evaluate the effect of the proportion of nHFT on respiratory outcomes.</p><p><strong>Methods: </strong>This was a single-centre retrospective study of preterm infants born <32 weeks' gestational age from 2016 to 2025. Propensity score weighting analysis was used to explore the effect of the duration of nHFT expressed as a percentage of the total duration of nHFT or nCPAP (nHFT%). The primary outcome was the total duration of respiratory support; secondary outcomes were the development of bronchopulmonary dysplasia (BPD) and the length of hospitalisation.</p><p><strong>Results: </strong>Three hundred and forty two infants were included. Infants received nHFT for a median (Q1, Q3) of 70 (46, 85) % of the duration of nHFT or nCPAP (nHFT%). After adjusting for residual confounders, the weighted nHFT% presented a significant positive association with the total duration of respiratory support (β = 0.007, p < 0.001), oxygen requirement (β = 0.006, p = 0.027), and the length of hospitalisation (β = 0.002, p = 0.007). The risk for BPD tended to increase with increasing nHFT% (OR = 1.01, p = 0.287).</p><p><strong>Conclusion: </strong>The prolonged use of nHFT as an alternative to nCPAP was associated with a longer duration of respiratory support and hospitalisation, but not with a higher risk for BPD.</p>","PeriodicalId":19932,"journal":{"name":"Pediatric Pulmonology","volume":"60 9","pages":"e71313"},"PeriodicalIF":2.3000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Duration of Nasal High Flow Therapy on Respiratory Outcomes in Very Preterm Infants: A Propensity Score Analysis.\",\"authors\":\"Emanuela Zannin, Camilla Rigotti, Giulia Dognini, Danila Azzolina, Maria Luisa Ventura\",\"doi\":\"10.1002/ppul.71313\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Nasal high flow therapy (nHFT) is being used earlier and for longer than in the past as an alternative to nasal Continuous Positive Airway Pressure (nCPAP) for preterm neonates. The aim of the present study was to evaluate the effect of the proportion of nHFT on respiratory outcomes.</p><p><strong>Methods: </strong>This was a single-centre retrospective study of preterm infants born <32 weeks' gestational age from 2016 to 2025. Propensity score weighting analysis was used to explore the effect of the duration of nHFT expressed as a percentage of the total duration of nHFT or nCPAP (nHFT%). The primary outcome was the total duration of respiratory support; secondary outcomes were the development of bronchopulmonary dysplasia (BPD) and the length of hospitalisation.</p><p><strong>Results: </strong>Three hundred and forty two infants were included. Infants received nHFT for a median (Q1, Q3) of 70 (46, 85) % of the duration of nHFT or nCPAP (nHFT%). After adjusting for residual confounders, the weighted nHFT% presented a significant positive association with the total duration of respiratory support (β = 0.007, p < 0.001), oxygen requirement (β = 0.006, p = 0.027), and the length of hospitalisation (β = 0.002, p = 0.007). The risk for BPD tended to increase with increasing nHFT% (OR = 1.01, p = 0.287).</p><p><strong>Conclusion: </strong>The prolonged use of nHFT as an alternative to nCPAP was associated with a longer duration of respiratory support and hospitalisation, but not with a higher risk for BPD.</p>\",\"PeriodicalId\":19932,\"journal\":{\"name\":\"Pediatric Pulmonology\",\"volume\":\"60 9\",\"pages\":\"e71313\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Pulmonology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/ppul.71313\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Pulmonology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ppul.71313","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Impact of Duration of Nasal High Flow Therapy on Respiratory Outcomes in Very Preterm Infants: A Propensity Score Analysis.
Background: Nasal high flow therapy (nHFT) is being used earlier and for longer than in the past as an alternative to nasal Continuous Positive Airway Pressure (nCPAP) for preterm neonates. The aim of the present study was to evaluate the effect of the proportion of nHFT on respiratory outcomes.
Methods: This was a single-centre retrospective study of preterm infants born <32 weeks' gestational age from 2016 to 2025. Propensity score weighting analysis was used to explore the effect of the duration of nHFT expressed as a percentage of the total duration of nHFT or nCPAP (nHFT%). The primary outcome was the total duration of respiratory support; secondary outcomes were the development of bronchopulmonary dysplasia (BPD) and the length of hospitalisation.
Results: Three hundred and forty two infants were included. Infants received nHFT for a median (Q1, Q3) of 70 (46, 85) % of the duration of nHFT or nCPAP (nHFT%). After adjusting for residual confounders, the weighted nHFT% presented a significant positive association with the total duration of respiratory support (β = 0.007, p < 0.001), oxygen requirement (β = 0.006, p = 0.027), and the length of hospitalisation (β = 0.002, p = 0.007). The risk for BPD tended to increase with increasing nHFT% (OR = 1.01, p = 0.287).
Conclusion: The prolonged use of nHFT as an alternative to nCPAP was associated with a longer duration of respiratory support and hospitalisation, but not with a higher risk for BPD.
期刊介绍：
Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases.
PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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