Pathology, research and practice最新文献_第4页

Nanozymes: A novel approach to upgrade atherosclerosis treatment

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-09 DOI: 10.1016/j.prp.2025.156005

Maryam Mahjoubin-Tehran , Prashant Kesharwani , Wael Alamahmeed , Sercan Karav , Amirhossein Sahebkar

{"title":"Nanozymes: A novel approach to upgrade atherosclerosis treatment","authors":"Maryam Mahjoubin-Tehran , Prashant Kesharwani , Wael Alamahmeed , Sercan Karav , Amirhossein Sahebkar","doi":"10.1016/j.prp.2025.156005","DOIUrl":"10.1016/j.prp.2025.156005","url":null,"abstract":"<div><div>Atherosclerosis has become a global health concern, contributing to the rise in cardiovascular diseases and causing significant morbidity and disability. The development of atherosclerosis begins with the accumulation of low-density lipoprotein (LDL) in the subendothelial space. As LDL becomes trapped in the arterial walls, reactive oxygen species (ROS) are generated, resulting in oxidative stress, impaired endothelial function, and oxidative modification of the retained LDL, forming oxidized LDL (ox-LDL). The oxidation of LDL to form ox-LDL is considered one of the most important factors in the development of atherosclerosis. Recently, there has been a growing interest in nanomaterials with enzyme-like characteristics called nanozymes in the field of biomedicine. The use of nanozymes has become increasingly popular because they offer solutions to the limitations associated with natural enzymes, including high costs, low stability, and challenging storage requirements. Nanozymes with anti-oxidative activities, such as catalase-, SOD-, and GPx-like nanozymes, have been extensively studied for various disease therapies, including atherosclerosis. Furthermore, nanozymes can be designed to have multiple enzyme-like activities. In this review, we aim to summarize studies that have used nanozymes as a therapeutic approach for the treatment of atherosclerosis. The results of this study have shown that nanozymes have a significant impact in reducing atherosclerotic plaques in <em>ApoE</em><sup><em>−/−</em></sup> mice. This effect is mainly achieved through ROS scavenging, which leads to the suppression of foam cell formation and inflammation.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"271 ","pages":"Article 156005"},"PeriodicalIF":2.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic re-classification of combined hepatocellular-cholangiocarcinoma and small duct type intrahepatic cholangiocarcinoma 肝细胞胆管合并癌和小管型肝内胆管癌的基因再分类

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-08 DOI: 10.1016/j.prp.2025.155999

Motoko Sasaki , Yasunori Sato , Yasuni Nakanuma

{"title":"Genetic re-classification of combined hepatocellular-cholangiocarcinoma and small duct type intrahepatic cholangiocarcinoma","authors":"Motoko Sasaki , Yasunori Sato , Yasuni Nakanuma","doi":"10.1016/j.prp.2025.155999","DOIUrl":"10.1016/j.prp.2025.155999","url":null,"abstract":"<div><h3>Background</h3><div>Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) shares various features with small duct type intrahepatic cholangiocarcinoma (SmD-iCCA) and sometimes histological diagnosis may be difficult.</div></div><div><h3>Methods</h3><div>We examined genetic alterations such as hTERT promoter (hTERT), p53, and fibroblast growth factor receptor 2 (FGFR2) in 103 PLCs diagnosed as cHCC-CCA or SmD-iCCA. A cluster analysis was performed on the R software for re-classification of PLCs including cHCC-CCA and SmD-iCCA.</div></div><div><h3>Results</h3><div>The primary liver carcinomas (PLCs) were divided into 5 clusters; 19 tumors (18 %) in Cluster-1 (with alterations in hTERT and/or p53), 24 (23 %) in Cluster-2 (FGFR2 and/or p53), 13 (13 %) in Cluster-3 (IDH2 or null), 19 (18 %) in Cluster-4 (MTAP and/or FGFR2), 28 (27 %) in Cluster-5 (ARID1A and/or PBRM1), being based on genetic alterations. Cluster-1 and Clusters-2 to- 5 formed distinct 2 groups. Cluster-1 was characterized by significantly bigger size, rich and higher histological grade of HCC component, significantly less cholangiolocellular carcinoma (CLC)-component, ductal plate malformation pattern and bile duct adenoma in the background livers. No SmD-iCCA was included in Cluster-1, whereas SmD-iCCA distributed evenly in Clusters 2–5. Cluster-4 was characterized by higher prevalence of hepatitis B and higher histological diversity scores.</div></div><div><h3>Conclusion</h3><div>PLCs diagnosed as cHCC-CCA or SmD-iCCAs could be divided into 5 clusters based on genetic alterations. Cluster-1 was HCC-like cluster characterized by hTERT alteration, rich and higher grade of HCC and bigger size. Clusters-2–5 may be iCCA-like clusters characterized by different genetic alterations. cHCC-CCA in Cluster-1 and Clusters-2–5 may be handled separately for further analysis and treatment.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155999"},"PeriodicalIF":2.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation 水飞蓟素/水飞蓟宾素对电离辐射的辐射防护和辐射敏化特性

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-07 DOI: 10.1016/j.prp.2025.156002

Faezeh Arghidash , Fatemeh Gheybi , Hamid Gholamhosseinian , Prashant Kesharwani , Amirhossein Sahebkar

引用次数: 0

Melatonin ameliorates RF-EMR-induced reproductive damage by inhibiting ferroptosis through Nrf2 pathway activation 褪黑素通过Nrf2通路激活抑制铁下垂，改善rf - emr诱导的生殖损伤

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-07 DOI: 10.1016/j.prp.2025.156003

Jingjing Wang , Jie Dong , Qian Xu , Song Yan , Haihui Wang , Hui Lei , Xuhui Ma , Tao Yang , Ke Wang , Zhen Li , Xiaohong Wang

{"title":"Melatonin ameliorates RF-EMR-induced reproductive damage by inhibiting ferroptosis through Nrf2 pathway activation","authors":"Jingjing Wang , Jie Dong , Qian Xu , Song Yan , Haihui Wang , Hui Lei , Xuhui Ma , Tao Yang , Ke Wang , Zhen Li , Xiaohong Wang","doi":"10.1016/j.prp.2025.156003","DOIUrl":"10.1016/j.prp.2025.156003","url":null,"abstract":"<div><div>In recent years, there has been increased attention to the deleterious impacts of radiofrequency electromagnetic radiation (RF-EMR) on male reproductive ability, necessitating the exploration of effective protective measures. Melatonin has antioxidant and anti-apoptotic effects, and there is growing evidence of its benefit to the reproductive process. However, the biochemical mechanisms by which melatonin protects against reproductive damage from RF-EMR exposure are unknown. Here, we found that prolonged (8 weeks) exposure to RF-EMR [2.45 GHz; power density, 2.5 W/m<sup>2</sup>; whole-body specific absorption rate (SAR), 0.125–0.5 W/kg] induced ferroptosis and oxidative stress in testicular tissue, leading to a decrease of sperm quality in male mice. Notably, the administration of melatonin mitigated the oxidative harm to the testicles and ferroptosis caused by RF-EMR in mice. Mechanistically, melatonin could inhibit ROS production and ferroptosis by stimulating the nuclear factor-erythroid 2-related factor 2 (Nrf2) signaling pathway through its receptors (MT1/MT2). Taken together, these results indicate that melatonin could potentially improve RF-EMR-induced reproductive damage in male mice by blocking ferroptosis through activation of the Nrf2 pathway.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 156003"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of uterine NK cells in pregnancy complication 子宫NK细胞在妊娠并发症中的作用

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-07 DOI: 10.1016/j.prp.2025.155998

Shahnaz Sabetkam , Ali Rafat , Zeinab Mazloumi , Hossein Kalarestaghi , Mohammadmahdi Bahramloo , Elahe Naderali , Khadijeh Dizaji Asl

{"title":"Role of uterine NK cells in pregnancy complication","authors":"Shahnaz Sabetkam , Ali Rafat , Zeinab Mazloumi , Hossein Kalarestaghi , Mohammadmahdi Bahramloo , Elahe Naderali , Khadijeh Dizaji Asl","doi":"10.1016/j.prp.2025.155998","DOIUrl":"10.1016/j.prp.2025.155998","url":null,"abstract":"<div><div>Remodeling of blood vessels and angiogenesis play a critical role in the pregnancy process, particularly at the implantation site. Both the innate and adaptive immune systems, especially uterine natural killer (uNK) cells, are involved in this process. During the first trimester, uNK cells constitute approximately 70 % of decidual leukocytes and are differentiated from CD34<sup>+</sup> progenitor cells. In comparison to peripheral blood NK cells, uNK cells secrete specific cytokines that promote tissue remodeling while exhibiting lower cytotoxic activity. Any disturbance in the function of uNK cells or dysregulation of their receptors can lead to reproductive failures. This review focuses on the role of uNK cells in pregnancy disorders such as preeclampsia, recurrent pregnancy loss, and endometriosis. The findings of this research will assist researchers in targeting specific checkpoints to address pregnancy disorders in clinical settings.</div></div><div><h3>Significance statement</h3><div>In this study, we highlight the evidence that NK cells play a pivotal role in pregnancy disorders and appropriate phenotype and normal expression of receptors on uNK cells affected pregnancy outcomes. In summary, arterial remodeling and correct implantation are related to the presence of various cytokines and factors in the uterine microenvironment. Collectively, it seems that the result of this study can be helpful in clinic. In the other word, specialist can use appropriate drugs in infertility.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155998"},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asiaticoside enhances the anti-tumor effect of anti-PDL1 by regulating T cell activity through increasing LCK activity 积雪草苷通过提高LCK活性来调节T细胞活性，从而增强抗pdl1的抗肿瘤作用

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-06 DOI: 10.1016/j.prp.2025.155995

Qingyi Ren , Fang Wang , Fei Du , Chenxi He , Xiaodong Wang , Jun Wang , Zhuo Zhang , Yuhong Sun

{"title":"Asiaticoside enhances the anti-tumor effect of anti-PDL1 by regulating T cell activity through increasing LCK activity","authors":"Qingyi Ren , Fang Wang , Fei Du , Chenxi He , Xiaodong Wang , Jun Wang , Zhuo Zhang , Yuhong Sun","doi":"10.1016/j.prp.2025.155995","DOIUrl":"10.1016/j.prp.2025.155995","url":null,"abstract":"<div><div>Anti-PD-L1 antibody confers anti-tumor effects, but its long-term use can provoke resistance and adverse effects. Asiaticoside, a bioactive triterpene glycoside from <em>Centella asiatica</em> L., regulates immune function and induces apoptosis of hepatocellular carcinoma (HCC) cells. T cells play a vital role in killing tumor cells and require lymphocyte-specific protein tyrosine kinase (LCK) for activation. Here, we examined whether a combined asiaticoside and anti-PD-L1 treatment regulates T cells via LCK activation to enhance the anti-tumor effect in vivo. We established a subcutaneous mouse HCC model using Hepa1–6 cells and measured spleen and tumor weight. Morphological changes of tumor tissues were assessed by hematoxylin-eosin staining. Tumor cell apoptosis and proliferation were determined by TUNEL staining and KI67 immunohistochemistry. The proportion of activated T cells in the spleen was detected by flow cytometry, and the levels of phosphorylated p-LCK and p-AKT in the spleen were determined by Western blotting. Changes in the levels of serum inflammatory factors were detected with ELISA. Our results revealed that the combined asiaticoside and anti-PD-L1 treatment inhibited tumor growth by enhancing apoptosis and reducing tumor cell proliferation. The treatment activated T cells to increase the proportion of effector T cells in the spleen, evidenced by upregulated p-LCK and p-AKT levels. It also increased the level of TNF-α in the serum and decreased IL-6, implying an enhanced immune response. In conclusion, the combined asiaticoside and anti-PD-L1 treatment enhances the anti-HCC effect in vivo by promoting LCK activation to regulate T cells.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"271 ","pages":"Article 155995"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of NCOA4-mediated ferritinophagy in the ferroptosis of hepatocytes: A mechanistic viewpoint ncoa4介导的铁蛋白自噬在肝细胞铁凋亡中的作用：一个机制观点

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-06 DOI: 10.1016/j.prp.2025.155996

Huixian Zhao , Zhixin Wang , Haijiu Wang

{"title":"The role of NCOA4-mediated ferritinophagy in the ferroptosis of hepatocytes: A mechanistic viewpoint","authors":"Huixian Zhao , Zhixin Wang , Haijiu Wang","doi":"10.1016/j.prp.2025.155996","DOIUrl":"10.1016/j.prp.2025.155996","url":null,"abstract":"<div><div>This paper focuses on the mechanism underlying nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy and subsequent hepatocyte ferroptosis. Iron is a pivotal trace element, but excessive iron deposition can lead to liver injury. Ferroptosis is a recognized, iron-dependent mode of programmed cell death that plays an important role in various liver diseases. NCOA4 is a key molecule mediating the selective autophagic degradation of ferritin. It affects ferroptosis by regulating intracellular free iron levels. NCOA4 expression is regulated by various factors, including cellular iron levels and oxidative stress. It was demonstrated that inhibition of NCOA4 can reduce iron-mediated cell death and mitigate liver damage, suggesting that NCOA4 may be a potential target for the prevention and treatment of liver diseases. Further in-depth studies of the molecular mechanism of NCOA4-mediated ferritinophagy and its relationship with iron-induced cell death can provide novel ideas for the diagnosis and treatment of liver diseases. The deficiency or abnormal expression of NCOA4 is closely associated with ferroptosis in a variety of liver diseases, including non-alcoholic fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver fibrosis. Future studies should focus on elucidating the dynamic changes in the NCOA4 regulatory network during specific pathological processes. This strategy can lay the foundation for drug development.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155996"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infiltrating Natural Killer cells influence the efficacy of BCG immunotherapy in non-muscle-invasive bladder cancer 浸润性自然杀伤细胞影响卡介苗免疫治疗非肌浸润性膀胱癌的疗效

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-05-06 DOI: 10.1016/j.prp.2025.155997

Mariana Z.T. Lima , Diogo A. Bastos , Romulo L. Mattedi , Carlos Dzik , Denis L.F. Jardim , Rafael Coelho , Leopoldo A. Ribeiro-Filho , Maurício D. Cordeiro , William C. Nahas , Evandro S. Mello , Mariane T. Amano , Lilian T. Inoue , Anamaria A. Camargo

{"title":"Infiltrating Natural Killer cells influence the efficacy of BCG immunotherapy in non-muscle-invasive bladder cancer","authors":"Mariana Z.T. Lima , Diogo A. Bastos , Romulo L. Mattedi , Carlos Dzik , Denis L.F. Jardim , Rafael Coelho , Leopoldo A. Ribeiro-Filho , Maurício D. Cordeiro , William C. Nahas , Evandro S. Mello , Mariane T. Amano , Lilian T. Inoue , Anamaria A. Camargo","doi":"10.1016/j.prp.2025.155997","DOIUrl":"10.1016/j.prp.2025.155997","url":null,"abstract":"<div><div>Non-muscle-invasive bladder cancer (NMIBC) consists of tumors restricted to the bladder urothelium or lamina propria, without invasion of the muscular layer. Intravesical BCG (Bacillus Calmette-Guérin) is widely used as an adjuvant therapy for patients with intermediate or high-risk NMIBC. However, a significant proportion of these patients fail to respond to BCG or recur after treatment. Moreover, despite decades of BCG usage, there are still no clinically validated biomarkers capable of predicting which patients will benefit from this treatment. Emerging evidence suggests that the tumor immune microenvironment influences the efficacy of BCG immunotherapy. In this context, our study aimed to assess, by immunohistochemistry, whether the abundance of immune cell subpopulations – Natural Killer (NK) cells, tumor-associated macrophages (TAMs), CD4 + T, CD8 + T, and FOXP3 + regulatory T (Treg) cells, or T cell ratios (CD4 +/CD8 + and FOXP3 +/CD8 +) – in NMIBC urothelium, prior to BCG, were associated with BCG response rate (RR) and recurrence-free survival (RFS) after treatment. We demonstrated that higher pretreatment NK cell count in the NMIBC urothelium is significantly associated with improved BCG RR and prolonged RFS after BCG immunotherapy. We hypothesize these results are associated with BCG-induced trained immunity, which has been proposed to be essential for the efficacy of BCG immunotherapy in bladder cancer. Once validated and further investigated by future studies, our findings may help to improve the stratification and treatment of patients with NMIBC.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155997"},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP46 regulates glycolysis in the process of cardiac hypertrophy through the HIF-1α pathway USP46通过HIF-1α途径调控心肌肥厚过程中的糖酵解

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-04-29 DOI: 10.1016/j.prp.2025.155980

Chunling Mu , Dahai Yu , Aixin Li , Yang Yu , Zhaoguang Liang

{"title":"USP46 regulates glycolysis in the process of cardiac hypertrophy through the HIF-1α pathway","authors":"Chunling Mu , Dahai Yu , Aixin Li , Yang Yu , Zhaoguang Liang","doi":"10.1016/j.prp.2025.155980","DOIUrl":"10.1016/j.prp.2025.155980","url":null,"abstract":"<div><div>Cardiac hypertrophy, a hallmark of various cardiovascular diseases, is characterized by metabolic reprogramming that leads to enhanced glycolytic activity. In the present study, we aimed to investigate the role of ubiquitin-specific protease46 (USP46) in regulating glycolysis of cardiac hypertrophy through the HIF-1α pathway. We provided evidence that USP46 was significantly elevated in hypertrophied mouse heart and in cell hypertrophy model, correlating with increased HIF-1α stability and activation of downstream glycolytic enzymes. We observed that knockdown of USP46 led to decreased HIF-1α levels and reduction in glycolysis rate, thereby attenuating myocardial hypertrophy in mice model of cardiac hypertrophy. Conversely, overexpression of USP46 enhanced the expression of HIF-1α, leading to increased glycolytic activity and exacerbation of cardiac hypertrophy. In vitro studies further demonstrated that USP46 enhances the stability of HIF-1α by binding to HIF-1α and reducing the ubiquitination of HIF-1α, thus promotes the transcriptional activity of HIF-1α, eventually facilitating the expression of metabolic genes associated with glycolysis. Metabolic profiling also confirmed that USP46/HIF-1α intervention significantly influenced lactate, pyruvate and ATP production in cardiac myocytes. Collectively, our findings suggest that USP46 plays a pivotal role in cardiac hypertrophy by modulating HIF-1α-dependent glycolytic processes. This study positions USP46 as a promising therapeutic target for the management of cardiac hypertrophy and related cardiovascular diseases, offering insights into the intricate interplay between deubiquitination, glycolysis, and cardiac remodeling.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155980"},"PeriodicalIF":2.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From blockage to biology: Unveiling the role of extracellular matrix dynamics in obstructive colorectal cancer pathogenesis 从阻塞到生物学：揭示细胞外基质动力学在梗阻性结直肠癌发病机制中的作用

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-04-28 DOI: 10.1016/j.prp.2025.155994

Jun Wang , Mian Chen , Guanxin Wei , Falong Zou , Junnan Gu , Yinghao Cao , Shenghe Deng , Kailin Cai

{"title":"From blockage to biology: Unveiling the role of extracellular matrix dynamics in obstructive colorectal cancer pathogenesis","authors":"Jun Wang , Mian Chen , Guanxin Wei , Falong Zou , Junnan Gu , Yinghao Cao , Shenghe Deng , Kailin Cai","doi":"10.1016/j.prp.2025.155994","DOIUrl":"10.1016/j.prp.2025.155994","url":null,"abstract":"<div><div>Colorectal cancer obstruction is a common problem with distinct symptomatic clues on CT/MR images even under incomplete conditions. The choice of management in the emergency setting has a significant effect on the prognosis of obstructive and nonobstructive colorectal cancer patients. Previous studies have demonstrated that obstruction in colorectal cancer is associated with significantly poorer outcomes, alongside distinct alterations in the composition of the extracellular matrix. Based on accumulating evidence, it is hypothesized that ECM remodeling plays a pivotal role in the development of colorectal cancer obstruction. This review explores the pathological features of obstructive colorectal cancer, emphasizing extracellular matrix remodeling as a central process. Key mechanisms include tumor-stromal cell interactions, tumor cell aggregation and migration mediated by the peripheral nervous system, vascular and lymphatic remodeling within the tumor microenvironment, and microbiota-mediated regulation of cancer progression. These findings demonstrate that further remodeling of the extracellular matrix may be a molecular biological feature of obstructive colorectal cancer with poor prognosis.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155994"},"PeriodicalIF":2.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0