Pathology, research and practice最新文献_第4页

Renal expression and clinical significance of Bach1-related oxidative stress indicators in patients with chronic glomerulonephritis

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155935

Hui Zhang , Xiao-lin Li , Jing-yao Lu , Qi Ke , Jun Li , Yuan Du , Ya-fen Yu

{"title":"Renal expression and clinical significance of Bach1-related oxidative stress indicators in patients with chronic glomerulonephritis","authors":"Hui Zhang , Xiao-lin Li , Jing-yao Lu , Qi Ke , Jun Li , Yuan Du , Ya-fen Yu","doi":"10.1016/j.prp.2025.155935","DOIUrl":"10.1016/j.prp.2025.155935","url":null,"abstract":"<div><div>Chronic glomerulonephritis (CGN) and diabetic kidney disease are the primary causes of chronic kidney disease in China. Oxidative stress participates in both the glomerular damage and tubular injury of glomerular diseases. In this study, we evaluated the renal expression and clinical significance of Bach1-associated oxidative stress markers in IgA nephropathy (IgAN), membranous nephropathy (MN) and diabetic nephropathy (DN) using immunohistochemical staining. Our study demonstrated that there was significantly increased expression of Bach1 in the renal tubular injury of all the patients with chronic glomerulonephritis yet with faint expression in glomerular endothelial cells. However, the expression levels of SLC25A39 and Grx2 were significantly decreased in the renal tubular lesions. The renal expression levels of 4-HNE were significantly elevated in the renal tubular injury of all the patients. While the expression levels of MDA were significantly higher in the renal lesions of patients with IgAN and DN compared to the patients with MN. The semi-quantitative scores of renal Bach1 and 4-HNE expression were positively correlated with the renal injury indicators. Whereas the semi-quantitative scores of renal SLC25A39 and Grx2 expression demonstrated a negative correlation with the renal injury indicators. Bach1-associated oxidative stress indicators may be the promising pathologic biomarkers of oxidative stress injury in the tubular injury of patients with chronic glomerulonephritis, which proposed potential therapeutic target.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155935"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fucoxanthin alleviates secondary brain injury in mice following intracerebral hemorrhage via PI3K-mediated inhibition of NF-κB signaling pathway

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155933

WeiBing Liu, WenHua Xu

{"title":"Fucoxanthin alleviates secondary brain injury in mice following intracerebral hemorrhage via PI3K-mediated inhibition of NF-κB signaling pathway","authors":"WeiBing Liu, WenHua Xu","doi":"10.1016/j.prp.2025.155933","DOIUrl":"10.1016/j.prp.2025.155933","url":null,"abstract":"<div><h3>Background</h3><div>ICH is an acute clinical cerebrovascular disease without effective treatments. This study was designed to investigate the therapeutic value of fucoxanthin in ICH treatment.</div></div><div><h3>Methods</h3><div>Animal ICH models were established by collagenase IV injection. ICH mice were given intraperitoneal injection of fucoxanthin (100mg/kg). Neurological deficits, brain edema, blood-brain barrier (BBB) integrity, and histological impairment were assessed. Nissl staining and TUNEL staining were performed to detect neuronal cell loss and apoptosis. The levels of tight junction proteins, apoptosis-related proteins, Iba-1, and pathway-related proteins were measured by immunofluorescence staining, western blotting, and ELISA.</div></div><div><h3>Results</h3><div>Fucoxanthin administration attenuated neurological deficits and brain injuries following ICH. Additionally, fucoxanthin alleviated neuronal apoptosis caused by ICH. Moreover, fucoxanthin inhibited microglia-mediated inflammation and M1 polarization in ICH models. Mechanistically, fucoxanthin inactivated the NF-κB pathway and triggered the activation of PI3K/Akt signaling after ICH, and LY294002 (a PI3K inhibitor) compromised the protective effect of fucoxanthin.</div></div><div><h3>Conclusion</h3><div>Fucoxanthin alleviates ICH-induced neurological deficits and brain injuries by suppressing the PI3K/Akt-mediated NF-κB pathway to inhibit M1 polarization and attenuate neuroinflammation, neuronal apoptosis, BBB dysfunction, and brain edema.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"270 ","pages":"Article 155933"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes in melanoma: Future potential for clinical theranostics

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155950

Asmit Das , Swarup Sonar , Rajib Dhar , Vetriselvan Subramaniyan

{"title":"Exosomes in melanoma: Future potential for clinical theranostics","authors":"Asmit Das , Swarup Sonar , Rajib Dhar , Vetriselvan Subramaniyan","doi":"10.1016/j.prp.2025.155950","DOIUrl":"10.1016/j.prp.2025.155950","url":null,"abstract":"<div><div>Melanoma, an aggressive form of skin cancer, presents significant therapeutic challenges due to its resistance to conventional treatments and propensity for metastasis. Exosomes, nanoscale vesicles secreted by a wide variety of cells, have emerged as promising tools for developing novel melanoma therapies. Exosome-based therapeutic approaches offer several advantages, including inherent biocompatibility, low immunogenicity, and the ability to cross biological barriers. This review explores the therapeutic potential of exosomes in melanoma treatment, focusing on their multifaceted roles in modulating tumor cell behavior, enhancing anti-tumor immune responses, and serving as targeted drug delivery vehicles. We discuss various strategies employed to engineer exosomes for enhanced therapeutic efficacy, including loading them with chemotherapeutic agents, small interfering RNAs (siRNAs), microRNAs (miRNAs), and immunomodulatory molecules. Additionally, we highlight the potential of exosomes derived from diverse sources to enhance anti-cancer effects. Furthermore, we address the challenges and future directions in translating exosome-based therapies from bench to bedside, emphasizing the need for standardized isolation and manufacturing protocols, as well as rigorous preclinical and clinical evaluations to unlock the full therapeutic potential of exosomes in the fight against melanoma.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155950"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomics evaluation and machine learning optimize molecular classification, prediction of prognosis and immunotherapy response for ovarian cancer

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155925

Fang Ren , Xiaoao Pang , Ning Liu, Liancheng Zhu

{"title":"Multiomics evaluation and machine learning optimize molecular classification, prediction of prognosis and immunotherapy response for ovarian cancer","authors":"Fang Ren , Xiaoao Pang , Ning Liu, Liancheng Zhu","doi":"10.1016/j.prp.2025.155925","DOIUrl":"10.1016/j.prp.2025.155925","url":null,"abstract":"<div><h3>Background</h3><div>Ovarian cancer (OC), owing to its substantial heterogeneity and high invasiveness, has historically been devoid of precise, individualized treatment options. This study aimed to establish integrated consensus subtypes of OC using different multiomics integration methodologies.</div></div><div><h3>Methods</h3><div>We integrated five distinct multiomics datasets from multicentric cohorts to identify high-resolution molecular subgroups using a combination of 10 and 101 clustering and machine learning algorithms, respectively, to develop a robust consensus multiomics-related machine learning signature (CMMS).</div></div><div><h3>Results</h3><div>Two cancer subtypes with prognostic significance were identified using multiomics clustering analysis. 10 essential genes were identified in the CMMS. Patients in the high CMMS group exhibited a poorer prognosis, with a “cold tumor” phenotype and an immunosuppressive state with reduced immune cell infiltration. In contrast, patients in the low CMMS group exhibited a more favorable prognosis, with immune activation and a “hot tumor\" phenotype characterized by increased tumor mutation burden, tumor neoantigen burden, PD-L1 expression, and enriched M1 macrophages. Eight independent immunotherapy datasets were validated to further corroborate our findings regarding patients in the low CMMS group who responded better to immunotherapy.</div></div><div><h3>Conclusions</h3><div>CMMS detection has significant utility in the prognosis of patients at an early stage and identification of potential candidates for immunotherapy.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155925"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel variation in the LMX1B gene with nail-patella syndrome

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155936

Lu Zhang , Jilong Xiong , Hiu-Ming Li , Xia Li , Xuewen Yu , Yingying Liang , Huili Sun , ShuDong Yang , Mumin Shao

{"title":"A novel variation in the LMX1B gene with nail-patella syndrome","authors":"Lu Zhang , Jilong Xiong , Hiu-Ming Li , Xia Li , Xuewen Yu , Yingying Liang , Huili Sun , ShuDong Yang , Mumin Shao","doi":"10.1016/j.prp.2025.155936","DOIUrl":"10.1016/j.prp.2025.155936","url":null,"abstract":"<div><div>Nail-patella syndrome (NPS; OMIM #161200) is an autosomal dominant disorder characterized by developmental defects in dorsal limb structures, kidneys, and eyes. The incidence of NPS is attributed to variations in the <em>LMX1B</em> gene. In this report, we present a novel <em>LMX1B</em> variation identified in a Chinese family affected by NPS. The proband, a 15-year-old male, exhibited a history of proteinuria and microscopic hematuria accompanied by renal dysfunction, nail dysplasia, bilateral patellar dysplasia, bilateral shoulder and elbow joint dysplasia and iliac horns. Histological examination revealed mild glomerular lesions. Under electron microscopy, irregular thickening of the glomerular basement membrane was observed, characterized by an appearance resembling occasional electron lucent areas (\"moth-eaten\" appearance) and the presence of disorganized collagen fiber bundles. Pathological findings were consistent with NPS. Genetic analysis identified a novel heterozygous variant, c.791 A>C, p.(Gln264Pro), in the patient, his father and younger brother. This new variant has been annotated as potentially pathogenic according to the recommendation of the American Society for Medical Genetics and Genomics. This represents the first report of a novel variation in the <em>LMX1B</em> gene. These findings expand the spectrum of variations associated with <em>LMX1B</em> in NPS.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155936"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GATA1 insufficiencies in dysmegakaryopoiesis of myelodysplastic syndromes/neoplasms

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-29 DOI: 10.1016/j.prp.2025.155930

Fuhui Li , Yudi Zhang , Chengwen Li , Qi Sun , Jinqin Liu , Tiejun Qin , Zefeng Xu , Bing Li , Shiqiang Qu , Lijuan Pan , Qingyan Gao , Meng Jiao , Zhijian Xiao

{"title":"GATA1 insufficiencies in dysmegakaryopoiesis of myelodysplastic syndromes/neoplasms","authors":"Fuhui Li , Yudi Zhang , Chengwen Li , Qi Sun , Jinqin Liu , Tiejun Qin , Zefeng Xu , Bing Li , Shiqiang Qu , Lijuan Pan , Qingyan Gao , Meng Jiao , Zhijian Xiao","doi":"10.1016/j.prp.2025.155930","DOIUrl":"10.1016/j.prp.2025.155930","url":null,"abstract":"<div><div>GATA1 is one of critical transcription factors for megakaryopoiesis and platelet production. Our study aimed to explore the correlations between GATA1 expression and dysmegakaryopoiesis in myelodysplastic syndromes/neoplasm (MDS). We assessed GATA1 expression level of megakaryocytes by performing immunohistochemical staining on bone marrow biopsy sections from MDS patients. According to GATA1 expression level of megakaryocytes and positive megakaryocyte percentage, we assigned each patient a GATA1 score. Compared with <em>TP53</em>-wildtype patients, GATA1 scores significantly decreased in <em>TP53-</em>mutated patients (<em>P</em> < 0.001). Patients with abnormal karyotypes showed decreased GATA1 scores than those with normal karyotypes (<em>P</em> = 0.024). GATA1 expression levels were significantly downregulated in dysplastic megakaryocytes, especially micromegakaryocytes (<em>P</em> < 0.001). Furthermore, we explored the correlation between GATA1 expression levels and cytogenetic abnormalities of the same megakaryocyte using the morphology antibody chromosome (MAC) technique on fresh bone marrow smears. We found that GATA1-negative megakaryocytes had higher frequencies of cytogenetic abnormalities. Our results indicated that decreased GATA1 expression level of megakaryocytes was significantly associated with <em>TP53</em> mutations, abnormal karyotypes and dysmegakaryopoiesis in MDS, suggesting that downregulation of GATA1 expression levels of megakaryocytes plays a critical role in the pathogenesis of MDS.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155930"},"PeriodicalIF":2.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of genetic factors in imatinib resistance of chronic myeloid leukemia: P53, RB1, ASS1 gene deletions, and chromosome 8 hyperdiploidy

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-28 DOI: 10.1016/j.prp.2025.155943

Aypara Hasanova , Chingiz Asadov , Aytan Shirinova , Gunay Aliyeva , Zohra Alimirzoyeva

{"title":"Role of genetic factors in imatinib resistance of chronic myeloid leukemia: P53, RB1, ASS1 gene deletions, and chromosome 8 hyperdiploidy","authors":"Aypara Hasanova , Chingiz Asadov , Aytan Shirinova , Gunay Aliyeva , Zohra Alimirzoyeva","doi":"10.1016/j.prp.2025.155943","DOIUrl":"10.1016/j.prp.2025.155943","url":null,"abstract":"<div><div>Additional genetic mutations alongside the BCR/ABL1 fusion gene in chronic myeloid leukemia (CML) patients suggest clonal evolution associated with disease progression. This study investigates the molecular determinants of imatinib resistance and disease progression in CML patients. Upon analyzing 141 study subjects undergoing imatinib therapy, encompassing both resistant cases and those showing favorable responses, a notable association emerged between certain genetic markers—such as P53 deletion and hyperdiploidy of chromosome 8—and resistance to imatinib therapy. Notably, patients with these genetic abnormalities experienced poor outcomes, particularly during blast crises. Conversely, RB1 gene mutations were absent in all cases and no direct association between ASS1 gene deletion and imatinib treatment resistance was observed. These findings emphasize the clinical relevance of identifying additional abnormalities alongside BCR/ABL1 translocation for predicting disease progression and guiding treatment strategies in CML.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155943"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides in breast cancer therapy: From mechanisms to emerging drug delivery and immunotherapy strategies

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-28 DOI: 10.1016/j.prp.2025.155946

Elmira Alaei , Farid Hashemi , Najma Farahani , Safa Tahmasebi , Noushin Nabavi , Salman Daneshi , Behnaz Mahmoodieh , Payman Rahimzadeh , Afshin Taheriazam , Mehrdad Hashemi

{"title":"Peptides in breast cancer therapy: From mechanisms to emerging drug delivery and immunotherapy strategies","authors":"Elmira Alaei , Farid Hashemi , Najma Farahani , Safa Tahmasebi , Noushin Nabavi , Salman Daneshi , Behnaz Mahmoodieh , Payman Rahimzadeh , Afshin Taheriazam , Mehrdad Hashemi","doi":"10.1016/j.prp.2025.155946","DOIUrl":"10.1016/j.prp.2025.155946","url":null,"abstract":"<div><div>Breast cancer therapy can be improved by the application of multifunctional peptides and they have unique features, such as high specificity, minimized toxicity, and the capability to influence diverse processes. The role of peptides in breas cancer therapy is highlighted in the present review, examining their functions as therapeutic agents, diagnostic tools, and drug delivery application. Therapeutic peptides have displayed the ability to regulate key pathways in breast tumor, including HER2, VEGF, and EGFR, providing ideal alternatives to the conventional chemotherapy with reduced adverse effects. Additionally, peptide-based vaccines and immune-modulating peptides have demonstrated the capacity in enhancing anti-cancer immunity. The incorporation of peptides into nanoparticles has improved the delivery of drugs and genes, enhanced anti-cancer efficacy while minimizing side impacts. The progresses in the peptide engineering, including stapled peptides, peptide-drug conjugates, and cell-penetrating peptides, have remarkably increased their therapeutic efficacy and stability, elevating their applications in breast cancer therapy. Peptides can be developed using bioinformatics and high-throughput screening technologies to optimize pharmacokinetics and bioavailability. Despite their promise, peptides demonstrate challenges such as enzymatic degradation, limited stability, and high production costs. These obstacles can be addressed through strategies such as peptide cyclization, the employement of non-natural amino acids, and nanoparticle encapsulation. This review explores these recent advancements and strategies, providing ideal insights into the clinical potential of peptides in breast tumor therapy.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155946"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric and graphical analysis of ferroptosis and aging research: Trends, gaps, and future directions

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-28 DOI: 10.1016/j.prp.2025.155949

Siyang Cao , Yingchen Pang , Yihao Wei , Deli Wang , Ao Xiong , Jun Yan , Hui Zeng

{"title":"Bibliometric and graphical analysis of ferroptosis and aging research: Trends, gaps, and future directions","authors":"Siyang Cao , Yingchen Pang , Yihao Wei , Deli Wang , Ao Xiong , Jun Yan , Hui Zeng","doi":"10.1016/j.prp.2025.155949","DOIUrl":"10.1016/j.prp.2025.155949","url":null,"abstract":"<div><div>Over the past 12 years, a significant body of evidence derived from extensive research has underscored the pivotal involvement of ferroptosis in the mechanisms underlying aging. Despite the growing body of literature on this topic, there remains a paucity of analytical and descriptive studies that explore its trajectory, key research directions, current trends, primary focal points, and future outlooks. This research endeavors to provide an exhaustive overview of the advancements in understanding the relationship between ferroptosis and aging over the past 12 years. The dataset utilized in this study was extracted from the Web of Science, encompassing records from January 1, 2012, through June 19, 2024. We conducted comprehensive bibliometric and visual analyses using advanced analytical tools. The results highlight China's dominant contribution, which accounts for 48.52 % of total publications, positioning it as a key player in this research area. Leading institutions, including Columbia University, Southern Medical University, and the Salk Institute for Biological Studies, demonstrate high research productivity. Pamela Maher and Gu Wei are identified as the most prolific researchers in this field. <em>Free Radical Biology and Medicine</em> is the leading journal, publishing the most articles in this field. This study identifies mitochondrial diseases, arrhythmias, Parkinson's disease, hepatocellular carcinoma, and iron-refractory iron deficiency anemia as the key diseases investigated in this field. This bibliometric evaluation offers critical perspectives for both experienced scholars and early-career researchers, enabling the identification of novel ideas and advancements within this domain.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155949"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing immunotherapy for hepatocellular carcinoma: Principles and emerging promises

IF 2.9 4区医学

Pathology, research and practice Pub Date : 2025-03-28 DOI: 10.1016/j.prp.2025.155928

Hossein Miri , Payman Rahimzadeh , Mehrdad Hashemi , Noushin Nabavi , Amir Reza Aref , Salman Daneshi , Alireza Razzaghi , Maryam Abedi , Safa Tahmasebi , Najma Farahani , Afshin Taheriazam

{"title":"Harnessing immunotherapy for hepatocellular carcinoma: Principles and emerging promises","authors":"Hossein Miri , Payman Rahimzadeh , Mehrdad Hashemi , Noushin Nabavi , Amir Reza Aref , Salman Daneshi , Alireza Razzaghi , Maryam Abedi , Safa Tahmasebi , Najma Farahani , Afshin Taheriazam","doi":"10.1016/j.prp.2025.155928","DOIUrl":"10.1016/j.prp.2025.155928","url":null,"abstract":"<div><div>HCC is considered as one of the leadin causes of death worldwide, with the ability of resistance towards therapeutics. Immunotherapy, particularly ICIs, have provided siginficant insights towards harnessing the immune system. The present review introduces the concepts and possibilities of immunotherapy for HCC treatment, emphasizing its underlying mechanisms and capacity to enhance patient results, focusing on both pre-clinical and clinical insights. The functions of TME and immune evasion mechanisms typical of HCC would be evaluated along with how contemporary immunotherapeutic approaches are designed to address these challenges. Furthermore, the clinical application of immunotherapy in HCC is discussed, emphasizing recent trial findings demonstrating the effectiveness and safety of drugs. In addition, the problems caused by immune evasion and resistance would be discussed to increase potential of immunotherapy along with combination therapy.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"269 ","pages":"Article 155928"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0