Pathology, research and practice最新文献

{"title":"The plica syndrome in the knee – A histopathological pilot study","authors":"David Grevenstein ,&nbsp;Andreas Mamilos ,&nbsp;Volker H. Schmitt ,&nbsp;Maximilian Babel ,&nbsp;Markus Rupp ,&nbsp;Lina Winter ,&nbsp;Christoph Brochhausen","doi":"10.1016/j.prp.2025.156152","DOIUrl":"10.1016/j.prp.2025.156152","url":null,"abstract":"<div><div>The plica syndrome, a condition caused by hypertrophy of the medial plica in the knee, is clinically characterized by antero-medial knee pain, especially in sport activities involving repetitive joint extension and flexion. Despite its high prevalence in young individuals, it is often overlooked, and there is a lack of systematic examination regarding characteristic histopathological changes associated with this syndrome. We performed a retrospective histological evaluation using haematoxylin-eosin, Elastica van Gieson and Berlin-blue staining and correlated clinical data of 45 plicae obtained from patients diagnosed with symptomatic plica syndrome. Our analysis focused on identifying characteristic pathological changes, especially acute and chronic inflammatory signs. The majority of examined plicae showed signs of fibrosis. Chronic inflammatory reactions dominated over acute inflammatory reactions. Additionally, hypertrophy of the synovial covering cells was observed. Lymphocyte aggregation occurred, while bleeding and fatty tissue reorganisation were rare. Our findings suggest that inflammation plays an active role in the development and maintenance of the plica syndrome. Future studies should prioritize the development of a histopathological scoring system for plica syndrome and the question whether the plica syndrome represents a risk factor for osteoarthritis.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156152"},"PeriodicalIF":3.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma: Clinical significance, prognostic impact, and correlation with microvessel density","authors":"Cong Xu ,&nbsp;Fanglong Li ,&nbsp;Zhen Li ,&nbsp;Conghui He ,&nbsp;Yanrong Feng ,&nbsp;Lanzhen Cui ,&nbsp;Lijun Zhang ,&nbsp;Xiaoming Li","doi":"10.1016/j.prp.2025.156147","DOIUrl":"10.1016/j.prp.2025.156147","url":null,"abstract":"<div><div>Cancer-associated fibroblasts (CAFs) play pivotal roles in facilitating tumor growth, recurrence, and metastasis. Nevertheless, studies examining the clinicopathological significance of CAFs and microvessel density (MVD) in hypopharyngeal squamous cell carcinoma (HPSCC), as well as their implications for prognosis, are scarce. Tissue samples from 96 HPSCC patients were subjected to immunohistochemistry (IHC) for CAF markers (including FAP and α-SMA) and MVD (characterized by the CD31 marker). Bioinformatics analysis was conducted to elucidate the potential mechanisms through which CAFs exert their functions. Compared with normal hypopharyngeal tissues, HPSCC tissues exhibited a greater number of CAFs and greater MVD. The high-MVD group demonstrated increased levels of FAP and α-SMA expression, increased CAF density, and an elevated rate of lymph node metastasis. Both CAF enrichment and high MVD were significantly associated with adverse clinicopathological features in patients, thereby leading to reduced overall survival. Additionally, both MVD and lymph node metastasis were identified as being independent prognostic factors that markedly increase patient mortality risk. Bioinformatics analyses revealed that CAFs may affect tumor progression, angiogenesis, and metastasis by the PI3K-Akt, KRAS, and Hedgehog signaling pathways, as well as through mechanisms such as epithelial-mesenchymal transition and ECM remodeling. CD19 may act as a potential marker for how CAFs affect the prognosis of head and neck squamous cell carcinomas. In summary, our findings indicate that CAFs and the MVD may significantly influence the prognosis of HPSCC patients. Angiogenesis and immunosuppression may represent the central mechanism through which CAFs affect prognosis, as CAFs facilitate angiogenesis and immunosuppression, thereby driving tumor progression and metastasis.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156147"},"PeriodicalIF":3.2,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell densities, HLA status, and PD-L1 expression in stage I neuroendocrine neoplasm of the uterine cervix","authors":"Rin Yamada ,&nbsp;Fumi Kawakami ,&nbsp;Naoko Maeda ,&nbsp;Shoji Nagao ,&nbsp;Mayuko Yamamoto ,&nbsp;Takeshi Motohara ,&nbsp;Eiji Kondoh ,&nbsp;Yoshiki Mikami ,&nbsp;Yoshihiro Komohara","doi":"10.1016/j.prp.2025.156146","DOIUrl":"10.1016/j.prp.2025.156146","url":null,"abstract":"<div><div>Neuroendocrine neoplasms (NENs) of the uterine cervix are highly malignant tumors associated with a poor prognosis. Human papillomavirus test-based uterine cervical cancer screening methods can detect early-stage uterine cervical NENs, so therapeutic strategies for the earliest stages are urgently needed. This study aimed to investigate and evaluate the prognostic significance of intratumoral and stromal immune cell densities, as well as human leukocyte antigen (HLA) and programmed cell death ligand 1 (PD-L1) expression in stage I uterine cervical NENs. Sixteen NENs were identified, including 8 large cell neuroendocrine carcinomas (LCNECs), 4 small cell neuroendocrine carcinomas (SCNECs), 3 neuroendocrine tumors (NETs), and 1 LCNEC with an SCNEC component. Only 3 cases were pure NENs, while 13 cases included a component of adenocarcinoma or squamous cell carcinoma. Eight of the 16 patients experienced postoperative recurrence. The recurrence-free group exhibited significantly higher densities of intratumoral CD3- and CD8-positive cells compared to the recurrence group (median densities: 136 vs. 48 cells/mm², <em>P</em> = 0.0281 and 91 vs. 27 cells/mm², <em>P</em> = 0.0359, respectively). No significant differences in clinicopathological characteristics, other immune cell densities, or expression of HLA class I, HLA-DR, or PD-L1 were observed between groups. HLA-DR expression was nearly absent in uterine cervical NENs, whereas adjacent non-NEN components displayed varying degrees of HLA-DR expression. PD-L1 expression was observed in 25 % of cases, with CD3- and CD8-positive T-cell-rich stroma. The observed modifications to tumor microenvironments could offer clues to future treatments for uterine cervical NEN. (240/250 words)</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156146"},"PeriodicalIF":3.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular carcinogenesis in Hodgkin lymphoma: Interplay between B lymphocyte mutations and NF-κB pathway dysregulation","authors":"Mohammed H. Abu-Alghayth","doi":"10.1016/j.prp.2025.156145","DOIUrl":"10.1016/j.prp.2025.156145","url":null,"abstract":"<div><div>Hodgkin lymphoma (HL) arises from aberrant B lymphocytes due to genetic mutations, epigenetic alterations, and persistent inflammation, leading to chronic hyperactivation of the NF-κB signaling cascade, which drives cell survival and immune evasion. The pathway regulates cell survival and immune response and is abnormally activated through an interplay between genetic mutations, epigenetic changes, and persistent inflammation. This review examines the relationship between B cell mutations and NF-κB signaling in the progression of HL. Particular focus is drawn to genetic mutations concerning Epstein-Barr virus (EBV)-related proteins, such as BCL6 and CREBBP, which are reported to cause disruptions in normal B cell formation and support aberrant cell growth. These observations suggest that genetic and epigenetic alterations protect cancer cells from apoptosis while sustaining inflammation and promoting tumor development. By integrating existing studies, this review aims to identify potential molecular targets of HL development and propose new therapeutic approaches. By better elucidating these pathways, future therapies can be designed to interfere with the mechanisms of disease advancement, holding promise for better patient care.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156145"},"PeriodicalIF":3.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydatin alleviates oxidative stress and pro-inflammatory activation of alveolar macrophages in chronic cough by reducing PTGS2 levels","authors":"Yan Zhao ,&nbsp;Naizhu Wang","doi":"10.1016/j.prp.2025.156143","DOIUrl":"10.1016/j.prp.2025.156143","url":null,"abstract":"<div><h3>Background</h3><div>Polydatin (PD) is a resveratrol derivative primarily isolated from <em>Polygonum cuspidatum</em> Sieb. et Zucc. with multiple pharmacological effects. This research investigates the treatment effect of polydatin (PD) on chronic cough and delves into its functional mechanism.</div></div><div><h3>Methods</h3><div>Mice with chronic cough were generated through ammonia and capsaicin exposure, followed by PD treatment. Pathological alterations in the mouse lung tissues were determined using histological staining. Inflammation and oxidative stress markers were detected in the mouse serum or lung tissue samples. Mouse alveolar macrophages, MH-S, were exposed to lipopolysaccharide (LPS) to generate inflammatory cell models. The treatment effect of PD on inflammatory cytokine production and oxidative stress in cells was analyzed. Downstream targets of PD were predicted using bioinformatics tools. Prostaglandin-endoperoxide synthase 2 (PTGS2) overexpression was induced in animal and cell models to analyze its involvement in PD's effects.</div></div><div><h3>Results</h3><div>PD treatment increased latency to cough and reduced cough frequencies of modeled mice, and it ameliorated inflammatory cell infiltration, collagen deposition, and mucus production in mouse lung tissues. Additionally, PD treatment reduced inflammatory cytokine production and oxidative stress markers both in mice and in LPS-challenged MH-S cells. PD reduced PTGS2 protein levels in mouse lung tissues and MH-S cells. Overexpression of PTGS2, introduced via lentiviral vectors, significantly counteracted the treatment effects of PD both <em>in vivo</em> and <em>in vitro</em>.</div></div><div><h3>Conclusion</h3><div>This research demonstrates that PD treatment reduces oxidative stress and pro-inflammatory activation of alveolar macrophages to ameliorate chronic cough in mice by reducing PTGS2 protein levels.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156143"},"PeriodicalIF":3.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and prognostic analysis of three clones of PD-L1 antibody in colorectal cancer","authors":"Wan-Wan Gao ,&nbsp;Bing Zhou ,&nbsp;Xin Chen,&nbsp;Guo-Xiang Xu,&nbsp;Fan Zhang,&nbsp;Wei Zhang","doi":"10.1016/j.prp.2025.156144","DOIUrl":"10.1016/j.prp.2025.156144","url":null,"abstract":"<div><div>PD-L1 is a well-established marker in colorectal cancer, whose expression is a crucial indicator for the efficacy of immunotherapy. However, different PD-L1 antibodies showed different results. Our study evaluated the expressions of PD-L1 antibody from three different clones (22C3, SP263, E1L3N) in colorectal cancer tissues, we analyzed and compared their expression consistency in tumor and stroma tissues, as well as investigating the correlation between PD-L1 expression and clinicopathological parameters and patient prognosis. PD-L1 was observed in both tumor cells and immune cells, exhibiting a mottled distribution pattern. Using 1 % as the threshold, the positive rates of CPS for the three clones were 31.5 % (22C3), 28.4 % (SP263), and 32.7 % (E1L3N), respectively. When comparing 22C3 and SP263, as well as SP263 and E1L3N, a high level of consistency was observed. However, moderate consistency was found between 22C3 and E1L3N. The positive rate of CPS in different antibodies was found to be associated with mismatch repair protein (MMR) and lymphatic metastasis, while showing no correlation with gender, age, tumor size, or other parameters. Survival analyses revealed that tumor location, chemotherapy and differentiation degree emerged as independent prognostic factors for patients, whereas there is no significant correlation between PD-L1 expression and overall patient prognosis in colorectal cancer. PD-L1 expression in tumor and immune cells exhibits a variegated and mottled pattern. Three clones of PD-L1 antibody demonstrated moderate to good consistency and potential interchangeability in their expression within colorectal cancer. PD-L1 expression may serve as an indicator of tumor microenvironment in colorectal cancer patients.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156144"},"PeriodicalIF":3.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian intraoperative consultation: A 5-year study on diagnostic concordance of 657 cases","authors":"Christopher Felicelli ,&nbsp;Olivia W. Foley ,&nbsp;Steven Smith ,&nbsp;Emily Hinchcliff ,&nbsp;Luis Z. Blanco Jr","doi":"10.1016/j.prp.2025.156142","DOIUrl":"10.1016/j.prp.2025.156142","url":null,"abstract":"<div><div>Diagnostic accuracy is critical in the assessment of ovarian lesions at the time of intraoperative consult (IOC), as surgical decision making is greatly affected by the type of diagnosis rendered. In this study, we aimed to assess the diagnostic accuracy of ovarian IOC at a major academic center over a 5-year period. A total of 657 cases of ovarian lesions were included within the study. The overall accuracy of diagnosis by biological behavior was 94.2 %, and the sensitivity of IOC diagnosis was 98.7 %, 88.5 %, and 87.1 % for benign, borderline, and malignant categories, respectively. Major diagnostic errors were predominantly secondary to sampling errors, with mucinous tumors posing a challenge with frequent upgraded diagnosis. While the assessment of ovarian IOC has been assessed in the past, our study incorporates high case volumes with subsequent diversity of neoplastic lesions encountered at a major tertiary academic center. This study continues to emphasize the importance of ovarian IOC, the overall high accuracy rate, and the dependence on IOC to guide clinical colleagues.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156142"},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal management of TAA-induced liver toxicity: Fibrosis, cirrhosis, and hepatocellular carcinoma","authors":"Ahmed A. Mohamed ,&nbsp;Aly A. Shoun ,&nbsp;Rana A. El-Kadi ,&nbsp;Sandra O. Abd El-Maseh ,&nbsp;Shimaa A. Abass","doi":"10.1016/j.prp.2025.156141","DOIUrl":"10.1016/j.prp.2025.156141","url":null,"abstract":"<div><div>The liver is responsible for the metabolism of the majority of currently utilized medicines and other foreign substances. Thioacetamide (TAA) is a potent hepatotoxin organosulfur compound. Moreover, TAA gained attention in research as a tool to induce liver injuries like inflammation, fibrosis, and cirrhosis, and to study liver regeneration. Several regimens are used to prevent and treat liver disease, but they have been linked with a variety of negative effects. Several natural substances have the potential to assist in the treatment and prevention of liver disease. Multiple mechanisms contribute to the efficacy of these herbal mixtures and their bioactive compounds in preventing and treating liver disease. TAA elicited the generation of ROS, provoked oxidative stress, and initiated apoptosis in hepatic cells via the JNK and MAPK pathways. Nevertheless, the adverse effects of TAA could be suppressed by natural plants, which not only eliminated ROS but also activated the PI3K-Akt cell survival pathway in the liver and prevented apoptosis approaches. Fuller understanding of the disease etiology and fibrotic processes is important for better prevention and treatment. This review aims to describe natural plant use in preventing and treating TAA-induced liver toxicity.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156141"},"PeriodicalIF":2.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features and prognostic insights of cutaneous versus non-cutaneous angiosarcoma: A retrospective single-center cohort study","authors":"Davide Voci ,&nbsp;Alexandru Grigorean ,&nbsp;Julia Neuenschwander ,&nbsp;Franca Lisy ,&nbsp;Riccardo M. Fumagalli ,&nbsp;Tim Sebastian ,&nbsp;Nils Kucher ,&nbsp;Rolf P. Engelberger","doi":"10.1016/j.prp.2025.156139","DOIUrl":"10.1016/j.prp.2025.156139","url":null,"abstract":"<div><h3>Introduction</h3><div>Angiosarcoma is a rare, aggressive malignancy of endothelial origin, accounting for 1–2 % of soft tissue sarcomas. It occurs in cutaneous (C-AS) and non-cutaneous (NC-AS) forms, with distinct clinical behaviors and prognoses. While C-AS primarily affects the head and neck, NC-AS involves visceral organs such as the heart, liver, and breast. Despite advances in treatment, survival remains poor, and recurrence is common.</div></div><div><h3>Methods</h3><div>This retrospective, single-center cohort study analyzed 30 patients diagnosed with angiosarcoma at the University Hospital Zurich (2000–2023). The study compared clinicopathological characteristics, survival outcomes, and prognostic factors influencing survival and recurrence. Patients were stratified into C-AS (n = 10) and NC-AS (n = 20) groups. Overall survival (OS) and recurrence-free survival (RFS) were assessed using Kaplan-Meier and Cox regression analyses.</div></div><div><h3>Results</h3><div>Both subtypes shared a poor prognosis, with an overall 5-year survival rate of 12 %. NC-AS had a higher early mortality rate, with a significantly worse median OS (9 vs. 36 months, p = 0.04), while early recurrence after treatment was more frequent in C-AS. High-grade tumor differentiation and metastases at diagnosis were independent predictors of poorer OS (p = 0.01; p = 0.04). Multimodal treatment, including surgery and radiotherapy, was associated with improved survival (p &lt; 0.05). No clinicopathological factor showed a statistically significant association with RFS.</div></div><div><h3>Conclusion</h3><div>C-AS and NC-AS exhibit distinct prognostic profiles, with NC-AS associated with a higher metastatic burden and worse outcomes. Prognostic factors such as tumor grade and metastases at diagnosis influence survival. Multimodal treatment strategies appear beneficial, though recurrence remains a major challenge. Further prospective studies are needed to refine therapeutic approaches and explore emerging targeted therapies.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156139"},"PeriodicalIF":2.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of sildenafil combined with statins in treating pulmonary hypertension secondary to chronic obstructive pulmonary disease","authors":"Ma-Li Zhuo ,&nbsp;Jin-long Xu ,&nbsp;Wen Zhang ,&nbsp;Guo-Wu Rao ,&nbsp;Quan Zheng","doi":"10.1016/j.prp.2025.156097","DOIUrl":"10.1016/j.prp.2025.156097","url":null,"abstract":"<div><h3>Aims</h3><div>This study aims to comprehensively assess the effectiveness and safety of combining sildenafil with statins for managing pulmonary hypertension secondary to COPD. By conducting a comprehensive meta-analysis, we seek to provide robust evidence to inform and optimize clinical decision-making for this challenging condition.</div></div><div><h3>Methods</h3><div>A systematic search of the literature was performed across various databases, such as CNKI, VIP Data, Wanfang Data, PubMed, Web of Science, and the Cochrane Library, to identify RCTs that assess the effectiveness of sildenafil and statins in combination for treating PH secondary to COPD.The search included all records available from the establishment of each database until October 2024.Data extraction and meta-analysis were carried out with RevMan 5.3 software. The primary outcome measures comprised 6MWD and mPAP. The secondary outcome measures included FEV1/FVC, hs-CRP,and PaO2.</div></div><div><h3>Results</h3><div>Our study encompassed a total of 12 randomized controlled trials involving 937 patients who all come from China.Our research findings indicate that Sildenafil combined with statins could enhance 6MWD,lower mPAP,rise FEV1/FVC and PaO₂, reduce hs-CRP of COPD-PH,in contrast to the control group.Adverse reactions associated with the combination therapy were generally mild and tolerable.</div></div><div><h3>Conclusion</h3><div>This combination therapy not only improves patients' exercise capacity, as evidenced by increased 6MWD, but also alleviates PH and enhances overall quality of life. Importantly, the therapy does not raise significant safety concerns. These findings support the integration of sildenafil-statin combination therapy into the clinical management of COPD-PH, offering a promising approach to improving patient outcomes.</div></div>","PeriodicalId":19916,"journal":{"name":"Pathology, research and practice","volume":"273 ","pages":"Article 156097"},"PeriodicalIF":2.9,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}