Pain Research & Management最新文献

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Comparison of Safety and Efficacy of Anesthesia Methods in Percutaneous Endoscopic Lumbar Discectomy: A Network Meta-Analysis. 经皮内窥镜腰椎间盘切除术中麻醉方法的安全性和有效性比较:网络 Meta 分析。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-12-06 eCollection Date: 2024-01-01 DOI: 10.1155/prm/8022643
Bin Zheng, Panfeng Yu, Yan Liang, Haiying Liu
{"title":"Comparison of Safety and Efficacy of Anesthesia Methods in Percutaneous Endoscopic Lumbar Discectomy: A Network Meta-Analysis.","authors":"Bin Zheng, Panfeng Yu, Yan Liang, Haiying Liu","doi":"10.1155/prm/8022643","DOIUrl":"10.1155/prm/8022643","url":null,"abstract":"<p><p><b>Background:</b> The objective of this study was to systematically evaluate the safety and efficacy of local anesthesia, general anesthesia, and epidural anesthesia in percutaneous endoscopic lumbar discectomy (PELD). <b>Methods:</b> We searched PubMed, EMBASE, and OVID databases for all relevant studies. All statistical analysis was performed using STATA 17.0. <b>Results:</b> Fourteen studies were finally included, comprising 7 randomized controlled trials and 7 retrospective studies. The total number of subjects across these studies was 1655, with 316 undergoing general anesthesia, 789 undergoing local anesthesia, and 550 undergoing epidural anesthesia. The meta-analysis of pairwise comparisons suggests that there are no differences among epidural, general anesthesia, and local anesthesia in terms of postoperative VAS, ODI, and surgery time. Regarding complications, general anesthesia has a higher complication rate compared with local anesthesia, but there are no differences between epidural and general anesthesia or between epidural and local anesthesia. In terms of anesthesia satisfaction, both general and epidural anesthesia have higher satisfaction rates compared with local anesthesia, with no significant difference between general and epidural anesthesia. The ranking of the best probabilities shows that epidural anesthesia has the lowest postoperative VAS and highest anesthesia satisfaction. General anesthesia has the lowest ODI scores. Local anesthesia has the fewest complications and operative time. <b>Conclusion:</b> Local anesthesia, general anesthesia, and epidural anesthesia are all safe and effective methods for PELD. Local anesthesia has advantages in complications and operation time. Epidural anesthesia is most advantageous in anesthesia satisfaction and postoperative VAS scores. General anesthesia is most advantageous in postoperative ODI. In the future, more multicenter RCTs are needed to further compare the safety and effectiveness of different anesthesia methods in PELD.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"8022643"},"PeriodicalIF":2.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cultural Adaptation and Psychometric Validation of the Simplified Chinese Version of the Fear Avoidance Component Scale (FACS).
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1155/prm/7966689
Zhongyi Tu, Junfang Miao, Yanzhao Zhang, Zhaohui Yang, Rui Xu, Randy Neblett
{"title":"Cultural Adaptation and Psychometric Validation of the Simplified Chinese Version of the Fear Avoidance Component Scale (FACS).","authors":"Zhongyi Tu, Junfang Miao, Yanzhao Zhang, Zhaohui Yang, Rui Xu, Randy Neblett","doi":"10.1155/prm/7966689","DOIUrl":"10.1155/prm/7966689","url":null,"abstract":"<p><p><b>Background:</b> Strong associations have been demonstrated between chronic musculoskeletal pain, pain-related fear-avoidance (FA) of activities of daily living, and functional disability. The Fear Avoidance Components Scale (FACS) is a patient-reported outcome (PRO) measure, which was designed to evaluate cognitive, emotional, and behavioural dimensions of FA. <b>Objective:</b> The study aims were to translate the English version of the FACS into Simplified Chinese and then to examine its psychometric properties. <b>Methods:</b> The translation and cross-cultural adaptation of the FACS from English to Chinese was performed with standard methodology. A group of 330 subjects with chronic musculoskeletal pain completed the FACS-Chi and additional FA-related PRO measures. The FACS-Chi was then completed a second time, 1 week later. <b>Results:</b> The FACS-Chi showed excellent internal consistency (Cronbach's alpha = 0.920) and test-retest reliability (ICC = 0.918). A confirmatory factor analysis of the 2-factor model determined in the original English version of FACS revealed an acceptable fit. Strong correlations were found between FACS-Chi scores and other PRO measures of perceived level of disability, pain catastrophizing, and pain-related anxiety (<i>p</i> < 0.001 for all analyses). <b>Conclusions:</b> The FACS-Chi demonstrated good psychometric properties, including excellent test-retest reliability and internal consistency and satisfactory construct validity. The FACS-Chi may be a useful measure of pain-related FA in Chinese-speaking patients with chronic musculoskeletal pain.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"7966689"},"PeriodicalIF":2.5,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tooth Sensitivity Following Hydrogen Peroxide Bleaching With and Without Ozone: A Randomized Controlled Trial: Tooth Sensitivity Following H2O2 Versus H2O2/Ozone Bleaching. 使用和不使用臭氧进行过氧化氢漂白后的牙齿敏感性:随机对照试验:过氧化氢漂白与过氧化氢/臭氧漂白后的牙齿敏感性。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.1155/2024/2695533
Saeed Awod Bin Hassan
{"title":"Tooth Sensitivity Following Hydrogen Peroxide Bleaching With and Without Ozone: A Randomized Controlled Trial: Tooth Sensitivity Following H<sub>2</sub>O<sub>2</sub> Versus H<sub>2</sub>O<sub>2</sub>/Ozone Bleaching.","authors":"Saeed Awod Bin Hassan","doi":"10.1155/2024/2695533","DOIUrl":"10.1155/2024/2695533","url":null,"abstract":"<p><p><b>Aims:</b> The aim of this investigation was to assess bleaching sensitivity following bleaching using either 38% H<sub>2</sub>O<sub>2</sub> only or 38% H<sub>2</sub>O<sub>2</sub> followed by ozone application. <b>Methods:</b> In this randomized controlled clinical investigation, 80 participants (40 females and 40 males) were randomly assigned to two groups (<i>n</i> = 40 each; 20 females and 20 males). The upper anterior teeth were bleached by 38% H<sub>2</sub>O<sub>2</sub> for 20 min followed by ozone application for 60 s (healOzone X4, KaVo Dental, Biberach, Germany) in Group 1 (test group). Meanwhile, the bleaching protocol in Group 2 (controls) included the application of just 38% H<sub>2</sub>O<sub>2</sub> for 20 min. Tooth sensitivity before and after bleaching was reported by the participants using a visual analog scale (VAS) from 0 to 10. Mann-Whitney <i>U</i> test, Wilcoxon signed-rank test, and regression analysis were used to analyze the data. Significant statistical outcomes were identified at <i>p</i> < 0.05. <b>Results:</b> Bleaching sensitivity was reported following both tested bleaching protocols (<i>p</i> < 0.001). However, less bleaching sensitivity was reported when ozone was applied for 60 s after bleaching with 38% H<sub>2</sub>O<sub>2</sub> (<i>p</i> < 0.001). Female participants reported more bleaching sensitivity regardless the applied bleaching protocol (<i>p</i> < 0.05). <b>Conclusions:</b> Bleaching protocols with 38% hydrogen peroxide were associated with less bleaching sensitivity when followed by ozone application on the teeth.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"2695533"},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of 4 mg and 8 mg Dexamethasone Added to Intrathecal Bupivacaine on Perioperative Analgesia Among Adult Orthopedic Patients at Sodo Christian Hospital: A Prospective Cohort Study. 索多基督教医院成人骨科患者围手术期镇痛在鞘内布比卡因中添加 4 毫克和 8 毫克地塞米松的效果:前瞻性队列研究。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8872988
Amanuel Essayas, Mebratu Legesse, Mebratu Tila, Ashagire Sintayhu, Eyosiyas Abreham, Getahun Dendir
{"title":"Effects of 4 mg and 8 mg Dexamethasone Added to Intrathecal Bupivacaine on Perioperative Analgesia Among Adult Orthopedic Patients at Sodo Christian Hospital: A Prospective Cohort Study.","authors":"Amanuel Essayas, Mebratu Legesse, Mebratu Tila, Ashagire Sintayhu, Eyosiyas Abreham, Getahun Dendir","doi":"10.1155/2024/8872988","DOIUrl":"10.1155/2024/8872988","url":null,"abstract":"<p><p><b>Background:</b> Several adjuvant drugs have been tried to prolong spinal anesthesia block. Currently, dexamethasone appears to be effective in extending the duration of sensory block and enhancing analgesia during surgery. It is unclear, however, whether administering dexamethasone at a dose of 8 mg offers any advantages over administering it at a dose of 4 mg. <b>Objective:</b> To compare the effect of adding 4 and 8 mg dexamethasone to intrathecal bupivacaine on perioperative analgesia among adult orthopedic patients at Sodo Christian Hospital from June 1 to October 31, 2021. <b>Methodology:</b> A total of 178 adult patients undergoing elective orthopedic surgery were randomly assigned to one of the two groups through a prospective cohort research design. A systematic random sampling method was used. For analysis, data were imported into EpiData v.4.6 and exported to SPSS v.25. Levene's test was used to verify homogeneity of variance, whereas the Shapiro-Wilk test was used to assess data distribution. The Mann-Whitney test and the independent sample <i>t</i>-test were employed to compare numerical variables between study groups. Category variables were determined using the chi-square test. <i>p</i> values were deemed statistically significant if they were less than 0.05. <b>Result:</b> Between groups, the perioperative and demographic features were similar. The mean durations of sensory block (347.42 ± 91.06 versus 341.46 ± 68.84), motor block (308.36 ± 80.91 versus 310.84 ± 75.50), and overall analgesia (421.51 ± 121.62 versus 412.40 ± 107.0) minutes did not show a statistically significant difference between the groups. In addition, there was no significant difference (<i>p</i> > 0.05) in postoperative analgesic use, initial analgesia rescue time, or pain severity, as measured by the Numerical Rating Scale (NRS). The addition of dexamethasone did not result in any issues, nor was there a statistically significant difference in the onset time between the two groups. <b>Conclusion:</b> Dexamethasone at a dose of 4 mg extends the duration of sensory, motor, and overall analgesia in a manner similar to that of 8 mg dexamethasone with comparable durations for both the initial analgesic request and overall analgesic use.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"8872988"},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NPD1 Relieves Neuropathic Pain and Accelerates the Recovery of Motor Function After Peripheral Nerve Injury. NPD1 能缓解周围神经损伤后的神经痛并加速运动功能的恢复
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1109287
Yu Tian, YanFang Liu, Chang Liu, SaiSai Huang
{"title":"NPD1 Relieves Neuropathic Pain and Accelerates the Recovery of Motor Function After Peripheral Nerve Injury.","authors":"Yu Tian, YanFang Liu, Chang Liu, SaiSai Huang","doi":"10.1155/2024/1109287","DOIUrl":"https://doi.org/10.1155/2024/1109287","url":null,"abstract":"<p><p>The incidence of peripheral nerve injury (PNI) in China is continuously increasing. With an inability to function due to sensory and motor abnormalities, patients with PNI suffer from neuropathic pain and subsequent lesions. Presently, effective treatments for PNI are limited. To determine the role of neuroprotectin D1 (NPD1) in PNI, a sciatic nerve crush injury model was developed to investigate the impact of NPD1 on sensory and motor function recovery following nerve injury. The results demonstrated that NPD1 administered at different time points might reduce mechanical allodynia and thermal hyperalgesia caused by PNI, and its analgesic effect was not tolerated. Immunohistochemistry analyses revealed that administering NPD1 to PNI mice decreased the spinal microglia and astrocyte activation and decreased the inflammatory factor expression in the spinal dorsal horn. Furthermore, NPD1 can inhibit the invasion of IBA-1<sup>+</sup> macrophages in dorsal root ganglions generated by nerve injury. Meanwhile, it can help rehabilitate motor and neuromuscular functions following PNI. The results indicate that NPD1 may be involved in the sensory and motor function recovery following PNI.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"1109287"},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Eye Color and Postoperative Pain in Female Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Prospective, Parallel-Group, Observational Study. 下颌臼齿症状性不可逆牙髓炎女性患者的眼色与术后疼痛之间的关系:一项前瞻性、平行小组观察研究。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8824366
Merve Sarı, Koray Yılmaz
{"title":"Association Between Eye Color and Postoperative Pain in Female Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Prospective, Parallel-Group, Observational Study.","authors":"Merve Sarı, Koray Yılmaz","doi":"10.1155/2024/8824366","DOIUrl":"10.1155/2024/8824366","url":null,"abstract":"<p><p><b>Background:</b> Current evidence indicates that some phenotypic characteristics, such as eye or hair color, might be associated with the experience of pain. We, therefore, compared the anesthetic success rate of inferior alveolar nerve block (IANB) and postoperative pain scores between light eyes and dark eyes in female patients who experienced symptomatic irreversible pulpitis (SIP) in a mandibular molar. <b>Methods:</b> This prospective, parallel-group, observational study was registered with ClinicalTrials.gov (NCT06206304). A total of 110 adult female patients who experienced moderate or severe pain with SIP participated in this study. All patients received IANB with 4% articaine with 1:100.000 epinephrine. Endodontic access cavity preparation was initiated after confirmation of IANB. Pain during treatment was recorded by using a Visual Analog Scale. Anesthetic success was recorded as \"none\" or \"mild\" pain. Root canal treatment was performed, with standardized protocols. Postoperative pain scores were also recorded at 24, 48, and 72 h and 7 days after treatment. Statistical analyses of the data were performed using the independent <i>t</i>-test, repeated measures ANOVA test, and Pearson's chi-square test. The statistical significance level was set at 0.05. <b>Results:</b> No significant differences were found in the success rate of IANB and postoperative pain scores between light- and dark-eyed patients at any time point (<i>p</i> > 0.05). The success rate of IANB was 72.73% and 67.27% for light- and dark-eyed patients, respectively. <b>Conclusion:</b> Pain scores decreased significantly after RCT in both groups on all days (<i>p</i> < 0.05). No significant differences were found in the success rate of IANB and postop pain scores between light- and dark-eyed female patients who experienced SIP in a mandibular molar. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06206304.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"8824366"},"PeriodicalIF":2.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases. 右美托咪定联合患者自控镇痛用于晚期癌症难治性疼痛患者的姑息镇静:对九个病例的回顾性分析
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4707707
Na Li, Yumei Wang, Meng Cui
{"title":"Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases.","authors":"Na Li, Yumei Wang, Meng Cui","doi":"10.1155/2024/4707707","DOIUrl":"10.1155/2024/4707707","url":null,"abstract":"<p><p><b>Background:</b> Cancer-related pain is a pervasive symptom affecting the quality of life in patients with malignant tumors. For those with refractory pain, palliative sedation combined with pain management is recommended. Dexmedetomidine (DEX), known for its unique \"awake sedation\" effect, remains relatively unexplored when used in conjunction with patient-controlled analgesia (PCA) for terminal-stage cancer patients. This study aimed to assess the safety and efficacy of DEX for palliative sedation with PCA in patients experiencing refractory pain. <b>Methods:</b> A retrospective analysis was conducted on terminal-stage cancer patients who received DEX for palliative sedation combined with PCA in a hospice ward between January 2020 and June 2023. Data collection included general patient information, laboratory tests, rating scales, pain and analgesia conditions, sedation details, palliative sedative effects, and changes in vital signs before and after sedation. <b>Results:</b> Nine patients with terminal-stage cancer received DEX palliative sedation at doses ranging from 0.2 to 1.0 <i>μ</i>g/kg·h combined with PCA for refractory pain. After 1 h of sedation and at the maximum sedation dose, the Richmond Agitation-Sedation Scale scores significantly decreased (all <i>p</i> < 0.001). While heart rate, blood oxygen saturation, and respiratory rate remained stable, systolic blood pressure and diastolic blood pressure after 1 h of sedation were significantly lower than presedation levels (<i>p</i> = 0.040 and <i>p</i> = 0.044, respectively). <b>Conclusion:</b> DEX emerges as a promising option for palliative sedation in terminal-stage cancer patients. When used in conjunction with PCA, DEX has been shown to effectively, safely, and stably control refractory pain without inducing adverse effects such as respiratory/circulatory depression.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"4707707"},"PeriodicalIF":2.5,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Postgraduate Education Deepen Temporomandibular Disorders Insights for Dental Professionals? 研究生教育能否加深牙科专业人员对颞下颌关节紊乱症的认识?
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3582362
Zejin Liu, Jie Xiang, Yi Liu, Xueman Zhou, Yating Yi, Jun Wang, Xin Xiong
{"title":"Does Postgraduate Education Deepen Temporomandibular Disorders Insights for Dental Professionals?","authors":"Zejin Liu, Jie Xiang, Yi Liu, Xueman Zhou, Yating Yi, Jun Wang, Xin Xiong","doi":"10.1155/2024/3582362","DOIUrl":"10.1155/2024/3582362","url":null,"abstract":"<p><p><b>Objective:</b> This study aims to investigate the impact of postgraduate education on the comprehension of Temporomandibular Disorders (TMDs) among dental professionals. <b>Methods:</b> A cross-sectional observational study was conducted, involving 348 dental professionals, including students and practicing dentists, categorized based on their educational background into two groups: bachelor's degree or lower (Group B) and master's degree or higher (Group M). Questionnaires were utilized to assess attitudes and knowledge across four TMDs-related domains. Statistical analysis was performed to compare responses between groups and identify differences in TMDs comprehension. <b>Results:</b> Among the 348 respondents, who participated in the study, 183 were students and 165 were practicing dentists, yielding a response rate of 79% (348/440). In the dentist group, 11 statements across every TMDs-related domain exhibited statistically significant differences in responses between Group B and Group M (<i>p</i> < 0.05). Only 2 responses from Group M conflicted with the standard answers, whereas Group B had 9 conflicting responses. In the student group, 11 statements also showed statistically significant differences between Group B and Group M (<i>p</i> < 0.05). Group M had no conflicting responses with the standard answers, while Group B had 7 conflicting responses. <b>Conclusions:</b> Postgraduate education deepened dental professionals' understanding of TMDs. Students improved more in the domains of \"diagnosis\" and \"treatment and prognosis,\" whereas practicing dentists enhanced more in the \"etiology\" domain. To further advance postgraduate education, there is a need for more systematic course designs for TMDs, emphasizing the enhancement of knowledge related to examination methods and treatment options.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"3582362"},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area. 阻断 Piezo2 通路可减轻口面部的炎症性疼痛和神经性疼痛
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-09-27 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9179928
Min-Jeong Jo, Jo-Young Son, Yu-Mi Kim, Jin-Sook Ju, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn
{"title":"Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area.","authors":"Min-Jeong Jo, Jo-Young Son, Yu-Mi Kim, Jin-Sook Ju, Min-Kyoung Park, Min-Kyung Lee, Dong-Kuk Ahn","doi":"10.1155/2024/9179928","DOIUrl":"10.1155/2024/9179928","url":null,"abstract":"<p><p>Although previous studies suggest that Piezo2 regulates chronic pain in the orofacial area, few studies have reported the direct evidence of Piezo2's involvement in inflammatory and neuropathic pain in the orofacial region. In this study, we used male Sprague Dawley rats to investigate the role of the Piezo2 pathway in the development of inflammatory and neuropathic pain. The present study used interleukin (IL)-1<i>β</i>-induced pronociception as an inflammatory pain model. Subcutaneous injection of IL-1<i>β</i> produced significant mechanical allodynia and thermal hyperalgesia. Subcutaneous injection of a Piezo2 inhibitor significantly blocked mechanical allodynia and thermal hyperalgesia induced by subcutaneously injected IL-1<i>β</i>. Furthermore, the present study also used a neuropathic pain model caused by the misplacement of a dental implant, leading to notable mechanical allodynia as a consequence of inferior alveolar nerve injury. Western blot analysis revealed increased levels of Piezo2 in the trigeminal ganglion and the trigeminal subnucleus caudalis after inferior alveolar nerve injury. Furthermore, subcutaneous and intracisternal injections of a Piezo2 inhibitor blocked neuropathic mechanical allodynia. These results suggest that the Piezo2 pathway plays a critical role in the development of inflammatory and neuropathic pain in the orofacial area. Therefore, blocking the Piezo2 pathway could be the foundation for developing new therapeutic strategies to treat orofacial pain conditions.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2024 ","pages":"9179928"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Gasserian Ganglion High-Voltage, Long-Duration Pulsed Radiofrequency Combined With Block on Acute/Subacute Zoster-Related Trigeminal Neuralgia. Gasserian 神经节高电压、长持续脉冲射频结合阻滞疗法对急性/亚急性带状疱疹相关三叉神经痛的疗效。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI: 10.1155/2024/1992483
Yinghao Song, Ziheng Yu, Jingjing Guan, Haisheng Wu, Qiaoling Liu, Min Yuan, Xinzhi Cheng, Bingyu Ling
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