Pain Research & Management最新文献

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Clinical Efficacy of Acupuncture Combined With Conventional Therapy for C5 Nerve Root Palsy After Posterior Cervical Decompression Surgery: A Randomized Controlled Study. 针刺联合常规治疗颈后减压术后C5神经根麻痹的临床疗效:一项随机对照研究。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-05-04 eCollection Date: 2025-01-01 DOI: 10.1155/prm/2625552
Hua Wei, Qingfeng Shen, Yuang Fu, Yubo Tan, Junwei Gao, Yingpeng Xia
{"title":"Clinical Efficacy of Acupuncture Combined With Conventional Therapy for C5 Nerve Root Palsy After Posterior Cervical Decompression Surgery: A Randomized Controlled Study.","authors":"Hua Wei, Qingfeng Shen, Yuang Fu, Yubo Tan, Junwei Gao, Yingpeng Xia","doi":"10.1155/prm/2625552","DOIUrl":"https://doi.org/10.1155/prm/2625552","url":null,"abstract":"<p><p><b>Objectives:</b> To observe the clinical efficacy of Tiaokou acupoint-penetrating Chengshan combined with conventional therapy for C5 nerve root palsy after posterior cervical decompression surgery. <b>Methods:</b> A total of 52 patients undergoing posterior cervical decompression surgery at Tianjin Union Medical Center from March 2020 to March 2023 were grouped using computer-generated random numbers. Group A (<i>n</i> = 26) received the treatment of acupuncture combined with conventional therapy. Group B (<i>n</i> = 26) received only conventional therapy. <b>Results:</b> The VAS scores of the two groups after treatment were significantly lower than scores before treatment (<i>p</i> < 0.01). The JOA scores, Lovett muscle strength grade, and shoulder ROM of the two groups after treatment were significantly higher than those before treatment (<i>p</i> < 0.01). After treatment, the VAS scores of Group A were significantly lower than those in Group B (<i>p</i> < 0.01) while the JOA scores, Lovett muscle strength grade, and shoulder ROM were significantly higher than those in Group B (<i>p</i> < 0.01). There were significant differences in VAS difference (<i>p</i> < 0.01) and JOA difference (<i>p</i> < 0.01) after 2 weeks of intervention treatment in Group A compared to Group B. There was a significant difference in the improvement of shoulder ROM in Group A after 2 weeks of intervention compared to Group B. <b>Conclusions:</b> The acupuncture method of Tiaokou acupoint-penetrating Chengshan combined with conventional nutritional support therapy was more effective in patients with C5 nerve root palsy after posterior cervical decompression surgery compared to conventional nutritional support therapy. <b>Trial Registration:</b> Clinical Trial Registry identifier: ChiCTR2300073583.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"2625552"},"PeriodicalIF":2.5,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Postcesarean Pain: A Prospective Cohort Study Using a 3-Question Questionnaire, Local Anesthesia Infiltration, and Observer Rating. 预测剖宫产后疼痛:一项使用3题问卷、局部麻醉浸润和观察者评分的前瞻性队列研究。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI: 10.1155/prm/6903333
Unyime S Ituk, Sapna Ravindranath
{"title":"Predicting Postcesarean Pain: A Prospective Cohort Study Using a 3-Question Questionnaire, Local Anesthesia Infiltration, and Observer Rating.","authors":"Unyime S Ituk, Sapna Ravindranath","doi":"10.1155/prm/6903333","DOIUrl":"https://doi.org/10.1155/prm/6903333","url":null,"abstract":"<p><p><b>Purpose:</b> Acute postoperative pain is a typical complaint following cesarean delivery (CD). The current standard for postcesarean pain management is the use of a multimodal analgesia regimen which is beneficial for many but may be inadequate for some patients. This study aimed to determine if combining patients' response to a pain rating questionnaire, their pain score during local anesthetic infiltration (LAI) preceding spinal anesthesia for CD, and an anesthesiologist's prediction of postcesarean pain severity can predict the intensity of postcesarean pain. <b>Methods:</b> This was a prospective study of ninety women undergoing scheduled CD under spinal anesthesia. Patients completed a pain rating questionnaire preoperatively and rated pain on LAI before spinal injection, and an anesthesiologist predicted the severity of postcesarean pain. Postoperative pain scores were assessed at rest and with movement at 6, 24, and 48 h after surgery. <b>Results:</b> The patient's expected postoperative pain (<i>β</i> = 0.39, <i>p</i>=0.0011), perceived analgesic requirements (<i>β</i> = 0.34, <i>p</i>=0.0002), pain on LAI (<i>β</i> = 0.22, <i>p</i>=0.004), and anesthesiologist's predicted postoperative pain severity (<i>β</i> = 0.22, <i>p</i>=0.01) were associated with mean postoperative pain after CD. The multivariate model analysis found that the pain rating questionnaire and the an anesthesiologist's prediction of postcesarean pain severity contributed to postoperative pain modeling (<i>R</i> <sup>2</sup> = 0.27). <b>Conclusion:</b> Combining a preoperative pain rating questionnaire with an anesthesiologist's prediction of postcesarean pain severity accounted for 27% of the variance in mean postoperative pain with movement and may be a useful tool in predicting postcesarean pain. <b>Implications:</b> This study highlights the potential of a combined preoperative pain rating questionnaire and anesthesiologist's predictions to improve postcesarean pain management. By accounting for 27% of the variance in mean postcesarean pain with movement, this approach could enhance pain management outcomes for CD patients.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"6903333"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do We Ask What the Deities Can Do for Us? The Roles of Dao Religion and Resilience in Suicidality in Chronic Pain. 我们是否问过神能为我们做些什么?道教与心理韧性在慢性疼痛患者自杀中的作用。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1155/prm/3056383
Ling-Jun Liu, Hsiu-Ling Peng, Edward Meng-Hua Lin, Wan-Ping Liang
{"title":"Do We Ask What the Deities Can Do for Us? The Roles of Dao Religion and Resilience in Suicidality in Chronic Pain.","authors":"Ling-Jun Liu, Hsiu-Ling Peng, Edward Meng-Hua Lin, Wan-Ping Liang","doi":"10.1155/prm/3056383","DOIUrl":"https://doi.org/10.1155/prm/3056383","url":null,"abstract":"<p><p><b>Objectives:</b> Resilience to pain is a protective factor against aversive pain outcomes, such as suicide. Religiosity as a cornerstone of resilience has been found to be associated with reduced risk of suicidality in chronic pain. However, affiliations to different religions have displayed differences in suicide risk. This study focuses on the roles of pain resilience and Dao religion in mitigating suicidal experience in individuals with chronic pain. <b>Methods:</b> This study adopted a mixed-method approach. A preliminary investigation was conducted regarding the internal consistency and construct validity of the translated version of the pain resilience scale (PRS). Qualitative data were collected through interviews with individuals experiencing chronic pain. Levels of PRS and gender were included in the logistic regression on the probability of suicide attempts. The role of Dao practice was qualitatively analyzed through narrative analysis. <b>Results:</b> Among the 24 participants, 14 were affiliated with the Dao religion; therefore, the transcripts of these 14 interviews were analyzed. Individuals with moderate scores on the PRS were 11.60 times less likely to have attempted suicide than those with low PRS scores. The likelihood further decreased by 38.7 times in those with high PRS scores. Four themes emerged from the qualitative interviews. The participants experienced a burden from pain, made efforts to please the deities in exchange for better pain control, continuously adjusted to pain, and ultimately developed a new perspective on the relationship between their religion and pain. Many individuals have engaged in Dao rituals to try to alleviate their physical and psychological pain. Most participants tended to offer a religious interpretation of enlightening moments after surviving a suicide attempt. <b>Discussion:</b> This study illustrates how pain resilience and Dao religious practices mitigate suicidality in chronic pain. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05148364.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"3056383"},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Epidural Pulsed Radiofrequency Treatment in Persistent Spinal Pain Syndrome: A Prospective Clinical Study. 硬膜外脉冲射频治疗持续性脊柱疼痛综合征的疗效:一项前瞻性临床研究。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.1155/prm/6200102
Burak Erken, Gunay Yolcu, Tuba Tanyel Saracoglu
{"title":"Efficacy of Epidural Pulsed Radiofrequency Treatment in Persistent Spinal Pain Syndrome: A Prospective Clinical Study.","authors":"Burak Erken, Gunay Yolcu, Tuba Tanyel Saracoglu","doi":"10.1155/prm/6200102","DOIUrl":"https://doi.org/10.1155/prm/6200102","url":null,"abstract":"<p><p><b>Background:</b> Persistent spinal pain syndrome type-2 (PSPS-II) is a chronic condition that is characterized by severe pain and results in disability and a significant reduction in quality of life. Despite the wide range of interventional pain treatments that are applied, depending on the complexity of the etiology, epidural pulsed radiofrequency (EPRF) application has emerged as an approach that has gained popularity in recent years. <b>Objective:</b> The objective of this study is to examine the efficacy of EPRF in patients diagnosed with PSPS-II. <b>Methodology:</b> In this prospectively designed study, patients with PSPS-II who had not responded to conservative treatments and epidural steroid injections were subjected to fluoroscopy-guided EPRF. Patients were evaluated with the Numeric Rating Scale (NRS) for pain severity and the Douleur Neuropathique-4 (DN-4) questionnaire for presence of neuropathic pain before the procedure and at one and three months after. Although the change in NRS score was established as the primary outcome measure, the change in the number of patients with neuropathic pain according to the DN-4 was determined as the secondary outcome measure. <b>Result:</b> In the final analysis, data from 42 patients were evaluated. The analysis of the time-dependent change in NRS revealed a statistically significant reduction in the scores for the first and third months, in comparison with the initial measurement. A significant decrease was observed in the number of patients diagnosed with neuropathic pain according to the DN-4 questionnaire in the first month, in comparison with the baseline. However, no significant change was noted in the third month. <b>Conclusion:</b> The utilization of EPRF for the treatment of chronic radicular pain in the setting of PSPS-II appears to be effective in the short term. Further studies are required to ascertain its long-term effects. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06239857.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"6200102"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Experimental Pain and Visual Feedback on the Accuracy and Precision of Knee Joint Position Sense. 实验性疼痛和视觉反馈对膝关节位置感准确度和精度的影响。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-10 eCollection Date: 2025-01-01 DOI: 10.1155/prm/9328803
Shaojun Liao, Lars Arendt-Nielsen, Kelun Wang, Rogerio Pessoto Hirata
{"title":"Effect of Experimental Pain and Visual Feedback on the Accuracy and Precision of Knee Joint Position Sense.","authors":"Shaojun Liao, Lars Arendt-Nielsen, Kelun Wang, Rogerio Pessoto Hirata","doi":"10.1155/prm/9328803","DOIUrl":"https://doi.org/10.1155/prm/9328803","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effects of experimental pain and visual feedback on the accuracy and precision of knee joint position sense following a period of motor training. <b>Methods:</b> Forty healthy young subjects (age: 24.5 ± 3.6 years old) underwent an 8 day motor training. After the training, they were instructed to perform a knee reposition task before and after receiving an injection of either hypertonic (pain group) or isotonic (control group) saline into the infrapatellar fat pad of the left knee. The Visual Analog Scale (VAS) was recorded for both groups. In each condition, participants were instructed to extend their knee to three predetermined target positions (30°, 45°, and 60°) for 10 repetitions, both with visual feedback (VF) and without visual feedback (NVF). The accuracy and precision of the knee reposition task were measured before and after the injection. Accuracy was determined by calculating the mean difference between the target angle and the actual angle achieved, while precision was determined by calculating the standard deviation of all actual angles. Data were analyzed using two-way ANOVAs and independent-samples <i>t</i>-tests to compare the pain and control groups. <b>Results:</b> The VAS were 4.14 ± 2.48 for the pain group and 0.83 ± 0.89 for the control group. There was a significant decrease in knee accuracy after the injection of hypertonic saline compared to movements before the injection during VF (<i>p</i>=0.009). The pain group showed significantly worse knee accuracy compared to the control group in the relative change of performance during VF (<i>p</i>=0.015). <b>Conclusions:</b> This study demonstrates that experimental knee pain impairs the accuracy of joint position sense, even after a period of motor training. This could serve as a helpful cue for individuals with knee pain to pursue timely treatment, thereby reducing the risk of additional injury. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04146311.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"9328803"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Chronic Postsurgical Pain Knowledge Among Surgical Nurses in a Turkish University Hospital. 土耳其某大学医院外科护士对慢性术后疼痛知识的评估
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1155/prm/9954969
Aysel Doğan, Runida Doğan, Dilek Güneş, Nazlıcan Bağci
{"title":"Assessment of Chronic Postsurgical Pain Knowledge Among Surgical Nurses in a Turkish University Hospital.","authors":"Aysel Doğan, Runida Doğan, Dilek Güneş, Nazlıcan Bağci","doi":"10.1155/prm/9954969","DOIUrl":"https://doi.org/10.1155/prm/9954969","url":null,"abstract":"<p><p><b>Objective:</b> Chronic postsurgical pain (CPSP) is a significant yet often underrecognized complication following surgical procedures, impacting patients' quality of life. Surgical nurses play a crucial role in postoperative care and pain management, making their knowledge of CPSP essential for improving patient outcomes. The aim of the study was to assess CPSP knowledge among surgical nurses in a Turkish University Hospital. <b>Methods:</b> This descriptive cross-sectional study included a total of 175 nurses. Data were collected from nurses employed in the surgical units of İnönü University hospital between May 15 and June 15, 2023. Personal information and knowledge-level forms created by the researchers were used for data collection. IBM SPSS Statistics v.25 was used for the statistical analysis. <b>Results:</b> The mean CPSP knowledge score of the nurses working in surgical clinics was 9.26 ± 1.40 (min. = 0, max. = 12) and 75.4% of them had sufficient knowledge. Surgical nurses' knowledge level of CPSP was influenced by their education level (<i>p</i> ≤ 0.001) and total duration of employment in the surgical department (<i>p</i>=0.002). <b>Conclusions:</b> Although most surgical nurses had sufficient CPSP knowledge, gaps remained, particularly among those with lower education levels and less experience. Targeted training programs and continuous professional development initiatives are recommended to enhance CPSP awareness and improve postoperative pain management practices.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"9954969"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Nonpharmacologic Interventions by Adults With High-Impact Chronic Pain in the United States: A Cross-Sectional Analysis. 在美国,患有严重慢性疼痛的成年人使用非药物干预:一项横断面分析。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI: 10.1155/prm/5213178
Natasha L Parman, Robert H Schmicker, Sean D Rundell
{"title":"Use of Nonpharmacologic Interventions by Adults With High-Impact Chronic Pain in the United States: A Cross-Sectional Analysis.","authors":"Natasha L Parman, Robert H Schmicker, Sean D Rundell","doi":"10.1155/prm/5213178","DOIUrl":"https://doi.org/10.1155/prm/5213178","url":null,"abstract":"<p><p><b>Introduction:</b> Few studies compare differences in the use of nonpharmacologic interventions (NPIs) between those with high-impact chronic pain (HICP) and low-impact chronic pain (LICP) or describe differences in the use of NPIs by locations of bothersome pain. <b>Objectives:</b> To describe the use of NPIs in HICP and LICP subgroups and to examine the association between locations of bothersome pain and use of NPIs among those with HICP. <b>Methods:</b> We used data from the 2019 National Health Interview Survey. After identifying respondents who reported having chronic pain, we then created high and low pain impact subgroups. Additional variables in our analyses included sociodemographic data, health characteristics, and pain management characteristics. Our analysis included descriptive statistics, Chi-squared tests, and adjusted survey-weighted logistic regression models. <b>Results:</b> The estimated prevalence of chronic pain in US adults was 19.9% (95% CI: 19.5-20.0), with 36.4% (95% CI: 35.1-38.0) of that group having HICP. Of those with HICP, 69.7% (95% CI: 67.6-71.9) reported using ≥ 1 NPIs in the past 3 months, compared to 62.9% (95% CI: 61.1-64.6) with LICP. The most frequently used NPI was physical, rehabilitative, or occupational therapy (25.9%, 95% CI: 24.0-27.9), and the least used was a peer support group (2.7%, 95% CI: 2.0-3.6). Among those with HICP, bothersome back pain (OR = 1.52, 95% CI: 1.19-1.95) and upper extremity pain (OR = 1.26, 95% CI: 1.003-1.59) are associated with the greater use of any NPIs compared to those without bothersome pain at these sites, respectively. <b>Conclusion:</b> Our findings highlight that most US adults with HICP have recently used NPIs to manage their pain, but the use of specific NPIs varied considerably. The odds of using NPIs were different depending on the locations of bothersome pain. Future work should examine barriers for access to specific NPIs or the use of NPIs by locations of bothersome pain.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"5213178"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake. 地佐辛通过激活κ-和μ-阿片受体,抑制去甲肾上腺素和血清素再摄取,在慢性疼痛中发挥镇痛作用。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-04-04 eCollection Date: 2025-01-01 DOI: 10.1155/prm/5656675
Zihan Liu, Anan Liu, Jing Chen, Jing-Rui Chai, Panwen Liu, Ru-Feng Ye, Jing-Gen Liu, Yu-Jun Wang
{"title":"Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake.","authors":"Zihan Liu, Anan Liu, Jing Chen, Jing-Rui Chai, Panwen Liu, Ru-Feng Ye, Jing-Gen Liu, Yu-Jun Wang","doi":"10.1155/prm/5656675","DOIUrl":"https://doi.org/10.1155/prm/5656675","url":null,"abstract":"<p><p><b>Background:</b> Dezocine is a leading analgesic in China used for relieving moderate to severe pain. Previous studies have characterized its pharmacological properties, demonstrating its role as a partial agonist at both the κ-opioid receptor (KOR) and the μ-opioid receptor (MOR), thereby producing potent antinociceptive effects in acute pain models. However, its efficacy and mechanisms in chronic pain management remained unclear. <b>Methods:</b> Chronic pain models, including chronic neuropathic pain and cancer pain, were employed using chronic constriction injury (CCI) of the sciatic nerve and bone cancer pain (BCP) methodologies, respectively. The assessment of the mechanical allodynia was conducted using a von Frey filament. <b>Results:</b> Dezocine, administered via the intraperitoneal route, alleviated both neuropathic pain and cancer pain in a dose-dependent manner, with ED<sub>50</sub> of 1.3 mg/kg and 1.6 mg/kg, respectively. In the CCI model, the analgesic effect of dezocine was significantly inhibited by pretreating with KOR antagonist nor-BNI, MOR antagonist β-FNA, α2-adrenoceptor antagonist yohimbine, and 5-HT2A receptor antagonist altanserin. In the BCP model, dezocine-induced analgesia was markedly suppressed by nor-BNI, β-FNA, and yohimbine but not altanserin. <b>Conclusion:</b> These results suggest that, in neuropathic pain, the analgesic effects of dezocine are mediated through KOR and MOR activation, together with norepinephrine reuptake inhibition (NRI) and serotonin reuptake inhibition. In contrast, in cancer pain, KOR and MOR activation and NRI are involved in mediating the analgesic effect of dezocine. This study, along with previous data, enhances our understanding of the potential clinical utility of dezocine and elucidates its mechanisms of action in chronic pain management.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"5656675"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Randomized, Double-Blind, Parallel-Controlled Trial: Addressing Kinesiophobia in Post-Meniscoplasty Patients Through Progressive Muscle Relaxation Training and Acupressure. 随机、双盲、平行对照试验:通过渐进式肌肉放松训练和指压疗法解决乳房下皱襞成形术后患者的运动恐惧症。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-03-31 eCollection Date: 2025-01-01 DOI: 10.1155/prm/1270985
Rui Xu, Junfang Miao, Yingxia Gong, Hongan Jia, Huijuan Wu, Weizhao Wang, Huijuan Wang, Mengmeng Dong, Ying Zhang
{"title":"A Randomized, Double-Blind, Parallel-Controlled Trial: Addressing Kinesiophobia in Post-Meniscoplasty Patients Through Progressive Muscle Relaxation Training and Acupressure.","authors":"Rui Xu, Junfang Miao, Yingxia Gong, Hongan Jia, Huijuan Wu, Weizhao Wang, Huijuan Wang, Mengmeng Dong, Ying Zhang","doi":"10.1155/prm/1270985","DOIUrl":"10.1155/prm/1270985","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; The increasing prevalence of kinesiophobia, or the fear of movement, among patients following meniscectomy has necessitated the exploration of effective rehabilitative interventions. Traditional methods of rehabilitation often do not adequately address the psychological components of recovery, leading to prolonged recovery times and decreased quality of life. &lt;b&gt;Objective:&lt;/b&gt; The objective of this study is to explore the effectiveness of psychological and traditional Chinese medical techniques, including progressive muscle relaxation training (PMRT) and acupressure, in treating kinesiophobia among patients after meniscus surgery. &lt;b&gt;Methods:&lt;/b&gt; This randomized clinical trial commenced in December 2021 at the Sports Medicine Department of a hospital in Gansu Province and concluded in February 2023. Seventy hospital inpatients with movement disorders who had undergone meniscus shaping surgery participated in the study (experimental Group 35 people, control Group 35 people). The control group received standard care. In addition to receiving routine care, the experimental group underwent an additional 30 min of PMRT and 5-10 min of acupressure. The kinesiophobia scores and pain scores were assessed using the Tampa Scale for Kinesiophobia (TSK) and Visual Analogue Scale (VAS) before the intervention, the first day after the intervention, the fifth day after the intervention, and on the day of discharge. On the day of discharge, the Knee Society Score (KSS) was used to assess the knee joint function of the patients. Statistical analysis was performed using repeated measures ANOVA. &lt;b&gt;Results:&lt;/b&gt; The study included 70 kinesiophobia patients following meniscoplasty, equally split between the experimental and control groups. Attrition resulted in 3 experimental group withdrawals and 2 from the control group, leaving 65 for the final analysis (32 experimental, 33 control). The average age of the patients was (67.03 ± 8.26) years, with an average BMI of (25.09 ± 2.88) kg/cm&lt;sup&gt;2&lt;/sup&gt;. Females accounted for 66.10% of the participants. There were no statistically significant differences between the two groups in terms of their preintervention TSK scores, VAS scores, and other baseline data (&lt;i&gt;p&lt;/i&gt; &gt; 0.05).There were no statistically significant differences in the kinesiophobia scores (TSK scores) and pain scores (VAS scores) between the experimental group and the routine care group both before the intervention and on the first day after the intervention (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). However, the fifth-day and discharge assessments revealed significant score improvements in the experimental group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), along with KSS scores indicating enhanced knee joint function compared to controls (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). &lt;b&gt;Conclusions:&lt;/b&gt; PMRT combined with acupressure effectively decreases kinesiophobia levels post-meniscoplasty, mitigates pain, fosters early functional exercise participation, and promotes knee joint function recovery. &lt;b&gt;Tri","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"1270985"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11976047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers and Facilitators to Implementing Acute Pain Services at King Faisal Hospital Rwanda. 卢旺达费萨尔国王医院实施急性疼痛服务的障碍和促进因素。
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.1155/prm/8360891
Gaston Nyirigira, Felix Rutayisire, Jackson Kwizera Ndekezi, Rulinda Kwizera, Kara L Neil
{"title":"Barriers and Facilitators to Implementing Acute Pain Services at King Faisal Hospital Rwanda.","authors":"Gaston Nyirigira, Felix Rutayisire, Jackson Kwizera Ndekezi, Rulinda Kwizera, Kara L Neil","doi":"10.1155/prm/8360891","DOIUrl":"10.1155/prm/8360891","url":null,"abstract":"<p><p><b>Background:</b> As a critical component of clinical care, every patient should have access to acute pain service (APS). Despite significant progress in its development, acute pain is under or inadequately treated, particularly in African countries. In addition, acute pain treatment and management has received insufficient clinical attention, resulting in inadequacies in postoperative pain relief, which has continued to be a significant challenge. <b>Aims:</b> This study aims to assess the knowledge, perceptions, and experiences of healthcare professionals about APS delivery at King Faisal Hospital Rwanda (KFH). <b>Methods:</b> Nine semistructured focus group discussions (FGDs) were conducted from April to May 2023. Participants were selected via random stratified sampling, and FGDs were conducted in internal medicine, anesthesia and the operating theater, obstetrics and gynecology, the intensive care unit, pediatrics, accident and emergency, medical doctors, physiotherapy, and the surgical ward departments at KFH. <b>Results:</b> Participants highlighted four key areas that can serve as either barriers or facilitators to implementing APS at KFH. These include healthcare provider skills and training; the development and implementation of standardized protocols; establishing a dedicated interdisciplinary APS team; and patient awareness and education. <b>Conclusions:</b> Having institutional systems in place, including standardized protocols, a dedicated team, and regular training opportunities, may help strengthen APS. Patient education and ensuring patients know their care options is another facilitator to improving APS.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"8360891"},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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