Pain Research & Management最新文献

{"title":"Exploring the Causal Link Between Plasma Lipidome and Trigeminal Neuralgia Using Bidirectional Mendelian Randomization.","authors":"Yuhang Peng, Xiaolin Zhang, Jinhua Guo, Mingxin Chen, Yuan Cheng, Jianhe Yue, Yongxiang Jiang","doi":"10.1155/prm/8746245","DOIUrl":"10.1155/prm/8746245","url":null,"abstract":"<p><p><b>Background:</b> Trigeminal neuralgia (TN) is a prevalent neurological disorder characterized by recurrent acute pain localized within the distribution area of the trigeminal nerve. This condition places a severe psychological and emotional burden on patients. Although lipids are associated with many diseases, their relationship with TN remains unclear. This study aims to investigate the causal association between plasma lipidome and TN using a bidirectional two-sample Mendelian randomization (MR) approach, with the ultimate goal of informing potential therapeutic strategies for TN management. <b>Methods:</b> We conducted a bidirectional two-sample MR analysis to systematically assess the causal relationship between plasma lipidome and TN. Genome-wide association study (GWAS) summary statistics for plasma lipidome and TN were obtained from publicly available datasets. The primary causal inference was performed using inverse variance weighted (IVW) regression, with complementary analyses including MR-Egger regression, weighted mode, simple mode, weighted median, and MR pleiotropy residuals and outliers (MR-PRESSO) to test for and adjust potential pleiotropy. Comprehensive sensitivity analyses were implemented to verify the robustness of our findings, including heterogeneity testing, leave-one-out analysis, and examination of directional pleiotropy. This multianalytical approach provides a rigorous framework for elucidating the potential role of plasma lipidome dysregulation in TN pathogenesis. <b>Results:</b> Our forward MR analysis results demonstrated that genetically predicted glycerophospholipids (GP) and glycerolipid family (GL) exert significant causal effects on TN risk. More specifically, phosphatidylinositol (PI) in the GP, as well as diacylglycerol and triacylglycerol in the GL, were significantly associated with reduced TN risk (<i>p</i> < 0.05, OR < 1). However, distinct molecular configurations of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) within the GP class exhibited differential impacts on TN susceptibility. The reverse MR analysis identified eight configurations of PC reduced TN risk (<i>p</i> < 0.05, OR < 1), with PC (18:0_18:2) showing a particularly notable bidirectional causal relationship with TN. Rigorous sensitivity analyses confirmed the absence of both heterogeneity (Cochran's <i>Qp</i> > 0.05) and horizontal pleiotropy (MR-Egger intercept <i>p</i> > 0.05) across all examined lipid species, supporting the robustness of these findings. <b>Conclusions:</b> This MR study establishes causal links between specific plasma lipidomes and TN risk, identifying protective lipid species and revealing a bidirectional relationship for PC, offering potential therapeutic targets for TN management.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"8746245"},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet B Treatment of the Forearm Alters Supraspinal Nociceptive Processing.","authors":"Peter D Drummond, Lechi Vo, Matthew Carabetta","doi":"10.1155/prm/6601529","DOIUrl":"10.1155/prm/6601529","url":null,"abstract":"<p><p>Exposing the skin to high levels of ultraviolet B (UVB) radiation induces an inflammatory response that upregulates local nociceptive processing; this, in turn, facilitates protective responses to limit further injury. In this study, the UVB model was used to explore additional effects of inflammation on supraspinal nociceptive processing. Thirty-one healthy participants attended two sessions approximately 24 h apart. In each session, pressure-pain thresholds and sensitivity to sharp stimulation and heat were assessed in both forearms, and pressure-pain thresholds and sensitivity to sharp stimulation were assessed on each side of the forehead. In a novel paradigm, supraspinal nociceptive processing was explored by assessing pain and blink reflexes to electrical stimulation of the forehead, paired with acoustic startle stimuli. At the end of the first session, UVB radiation at a dose sufficient to induce erythema at the most exposed site was administered to one forearm. Consistent with local sensitization, sensitivity to heat and sharp stimulation had increased at the maximally exposed site 24 h later. This local response was accompanied by changes in supraspinal nociceptive processing-pressure-pain thresholds were lower on the ipsilateral than contralateral side of the forehead, and acoustic startle stimuli augmented electrically evoked pain. Blink reflexes weakened from the first to the second session, but decreases were smaller on the UVB-treated than contralateral side. Together, these findings suggest that acoustic startle stimuli facilitated activity in sensitized supraspinal nociceptive pathways. Potentially, this supraspinal mechanism adds to the burden of chronic nociplastic pain during states of heightened arousal and stress.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"6601529"},"PeriodicalIF":2.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Status and Disability in Activities of Daily Living Among Older Adults in China: Evidence From CHARLS 2020.","authors":"Jingjing Chu, Luxi Weng, Wen Jin, Xi Yin, Qin Xu, Zherong Xu","doi":"10.1155/prm/4974163","DOIUrl":"10.1155/prm/4974163","url":null,"abstract":"<p><p><b>Background:</b> Pain status is a common concern among older adults and has been linked to functional limitations. This study aimed to examine the association between pain status and disabilities risk in basic activities of daily living (BADL) and instrumental activities of daily living (IADL) in older adults in China, using data from the 2020 China Health and Retirement Longitudinal Study (CHARLS). <b>Methods:</b> A cross-sectional analysis was conducted using data from 8102 participants aged 60 and older from the 2020 CHARLS. Univariate and multivariate binary logistic regression analyses were performed to assess the association between pain status and BADL/IADL disabilities. We further examined the contribution of each covariate and categorized participants by pain location and number of pain sites. Subgroup analyses were conducted to examine the consistency of findings across demographic and health-related factors. <b>Results:</b> Pain status was significantly associated with higher odds of both BADL and IADL disabilities (<i>p</i> < 0.05), even after adjusting for covariates. Self-rated health and depressive symptoms exerted the greatest influence on the OR values. Pain in any anatomical region, particularly when present at multiple sites, was associated with increased odds of disability. Head and neck pain was specifically associated with IADL disability, while pain in the upper limbs, torso, and lower limbs was associated with both BADL and IADL disabilities. Subgroup analyses confirmed the robustness of these associations. <b>Conclusions:</b> Pain status, especially multisite pain, is significantly associated with BADL and IADL disabilities in older Chinese adults. Although causality cannot be inferred due to the study's cross-sectional design, these findings underscore the importance of addressing pain alongside other health and psychological factors when developing strategies to support functional independence in aging populations.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"4974163"},"PeriodicalIF":2.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Myofascial Release Combined With Capacitive-Resistive Therapy in Patients With Chronic Nonspecific Low Back Pain: A Randomized Controlled Trial.","authors":"Peng Zhao, Zhoupeng Lu, Hui Zou, Jialin Wang, Yuwei He, Meng Li, Jianfa Xu, Xinwen Cui","doi":"10.1155/prm/9309502","DOIUrl":"10.1155/prm/9309502","url":null,"abstract":"<p><p><b>Background:</b> Chronic nonspecific low back pain (CNLBP) is often associated with impaired mobility, functional limitations, and psychological distress. While myofascial release (MFR) and capacitive-resistive therapy (TECAR) have individually shown potential benefits, evidence regarding their combined application is limited. <b>Methods:</b> This assessor-blinded, three-arm randomized controlled trial included 67 patients with CNLBP. Participants were assigned to MFR alone, resistive-mode TECAR (R-TECAR) alone, or MFR plus R-TECAR. Interventions were administered twice weekly for 4 weeks, with each session lasting 20 min. Primary outcomes included the Numeric Pain Rating Scale (NPRS) and the Roland-Morris Disability Questionnaire (RMDQ), assessed at the baseline, 4 weeks, and one-and-a-half-month follow-up. Secondary outcomes encompassed thoracolumbar fascia (TLF) thickness, pressure pain threshold (PPT), trunk mobility, quality of life, anxiety, and depression. Intention-to-treat analyses were performed. <b>Results:</b> All interventions yielded significant improvements in pain and disability over time, although the combined MFR + R-TECAR therapy did not achieve statistically significant additional benefits compared with single therapies. Notably, a significant interaction effect emerged for PPT in the right quadratus lumborum muscle (<i>p</i>=0.01), with the MFR + R-TECAR group demonstrating greater improvement than R-TECAR alone. Other secondary outcomes, including TLF thickness and psychometric measures, improved over time but showed no significant between-group differences. <b>Conclusions:</b> Combining MFR with R-TECAR for CNLBP did not produce superior outcomes compared with individual treatments though certain muscle-specific benefits were observed. Future research should focus on optimizing treatment parameters, extending intervention and follow-up periods, and exploring individualized approaches to maximize therapeutic efficacy. <b>Trial Registration:</b> Chinese Registry of Clinical Trials: ChiCTR2400087961.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"9309502"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Neuroscience Education and Resistance Training in Women With Fibromyalgia: A Randomized Control Pilot Study.","authors":"Álvaro-José Rodríguez-Domínguez, Manuel Rebollo-Salas, Raquel Chillón-Martínez, Melania Cardellat-González, Laura Blanco-Heras, José-Jesús Jiménez-Rejano","doi":"10.1155/prm/7550108","DOIUrl":"10.1155/prm/7550108","url":null,"abstract":"<p><p><b>Objective:</b> The objective was to compare the effectiveness of a combined pain neuroscience education and resistance training program (PNE + RT) with that of a combined aerobic and flexibility exercise program (AE + FE). <b>Design:</b> A randomized pilot study was conducted in women with fibromyalgia. <b>Methods:</b> Thirty-one women with fibromyalgia were randomized into the experimental group (PNE + RT, <i>n</i> = 15) and the usual care group (AE + FE, <i>n</i> = 16). Both groups carried out the intervention 3 days a week for 12 weeks. Primary outcomes were pain intensity, disability, and symptoms related to central sensitization (CS). Among them, pain intensity was considered the main primary endpoint for statistical analysis and interpretation. Secondary outcomes were pressure pain threshold (PPT), maximum handgrip strength (MHS), and stiffness. <b>Results:</b> Statistically significant between-group differences were found in favor of PNE + RT group for short-term pain intensity (<i>p</i> < 0.05) and PPT trapezius (<i>p</i> < 0.05). PNE + RT also showed statistically significant within-group improvements in pain intensity (<i>p</i> < 0.01), CS-related symptoms (<i>p</i> < 0.01), PPT quadriceps (<i>p</i> < 0.01), and MHS of the left hand (<i>p</i> < 0.01). Disability improved significantly in both groups (<i>p</i> < 0.01). There were no significant changes in stiffness. <b>Conclusion:</b> The PNE + RT program is more effective than the AE + FE program in improving pain intensity in the short term and PPT in the trapezius muscle in the long term. PNE + RT is also effective in improving disability, pain intensity, CS-related symptoms (short and long term), and left MHS and PPT in the quadriceps muscle (long term), although it is not more effective than AE + FE. The AE + FE program is only effective in improving disability. These findings are preliminary, and larger studies are needed to confirm the results. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04855851.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"7550108"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Bupivacaine Liposomal in Intercostal Nerve Block for Postoperative Pain Management Following Uniportal Thoracoscopy: A Randomized Trial.","authors":"Lingjun Dong, Xiang Wang, Linhai Fu, Zongming Jiang, Yulong Wang, Aixia Chen, Jianyi Ding, Guangmao Yu","doi":"10.1155/prm/8816879","DOIUrl":"10.1155/prm/8816879","url":null,"abstract":"<p><p><b>Background:</b> Postoperative pain in thoracic surgery often requires opioids, yet can be poorly managed with short-acting anesthetics. Liposomal bupivacaine (LB) offers prolonged analgesia, potentially improving pain control and reducing opioid use. This study evaluates LB's effectiveness and safety in thoracic postoperative pain management, aiming to provide an alternative to current practices. <b>Methods:</b> In this single-center, double-blind, prospective, randomized controlled trial, patients undergoing uniportal lobectomy, segmentectomy, or wedge resection from November 2023 to May 2024 were enrolled. Participants were randomly assigned in a 1:1 ratio to receive either 0.375% ropivacaine (control group, <i>n</i> = 57) or LB (LB group, <i>n</i> = 56) for intercostal nerve blocks (ICNBs). Postoperative visual analog scale (VAS) scores, opioid consumption, overall benefit of analgesia score (OBAS), chest tube duration, length of hospital stay, and adverse events (AEs) were recorded and analyzed. <b>Results:</b> Data from 57 patients in the control group and 56 patients in the LB group were included in the analysis, with no significant demographic differences between the groups. The LB group demonstrated lower VAS scores at rest and during activity (<i>p</i> > 0.05), reduced opioid consumption (<i>p</i>=0.021), and higher OBAS (<i>p</i> < 0.01) compared with the control group. No significant differences were observed in chest tube duration, length of hospital stay, or AEs between the groups. <b>Conclusion:</b> LB is safe and effective for ICNB, providing significant postoperative pain relief for patients undergoing uniportal thoracoscopic surgery. <b>Trial Registration:</b> Chinese Registry of Clinical Trials: chiCTR2300075463.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"8816879"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Migraine With Phytocannabinoids, the Involvement of Endocannabinoids in Migraine, and Potential Mechanisms of Action.","authors":"Roger Gregory Biringer","doi":"10.1155/prm/7181066","DOIUrl":"10.1155/prm/7181066","url":null,"abstract":"<p><p>The American Migraine Foundation estimates that over 39 million Americans and over 1 billion people worldwide suffer from some form of migraine. Treatment of migraine generally falls into two categories: treatment of attacks once they have begun, and prophylactic prevention, including lifestyle changes. The use of phytocannabinoids to reduce both the frequency and severity of migraine is widely documented in scientific, grey, and popular literature. This review provides descriptions of both preclinical and clinical studies involving the treatment of migraines with phytocannabinoids as well as the involvement of endocannabinoids and endocannabinoid-like compounds in migraine pathology, including the receptors and associated mechanisms. Currently unanswered questions and areas for further exploration are discussed.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"7181066"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Cortical Surface Area in the Frontal Operculum as a Causal Risk Predictor for Chronic Pain.","authors":"Xiuzhi Wang, Yipeng Le, Xichen Wang, Yingchao Song, Qian Su, Xiaoxiao Xiao, Yifan Li, Wen Qin, Chunshui Yu, Meng Liang","doi":"10.1155/prm/4687197","DOIUrl":"10.1155/prm/4687197","url":null,"abstract":"<p><p>Chronic pain is a prevalent and debilitating condition that imposes substantial personal and societal burdens. Despite its significance, the neural mechanisms underlying individual susceptibility to chronic pain remain inadequately understood. In this study, we examined the prospective associations between 1325 brain structural imaging phenotypes and the future risk of developing chronic pain in a UK Biobank cohort of 5754-5756 participants. These phenotypes encompassed regional and tissue volume, cortical surface area and thickness. General linear models (GLMs) were employed to identify brain structural variations associated with the risk of developing chronic pain, and then Mendelian randomization (MR) was employed to explore potential causal relationships between brain structure and chronic pain development. GLMs identified three significant associations between imaging phenotypes and the future development of chronic pain. All three imaging phenotypes pertained to the cortical surface area of the frontal operculum, albeit derived from three different brain atlases. Specifically, reduced cortical surface area in the frontal operculum was significantly associated with an increased risk of developing chronic pain: BA atlas area 44 (<i>T</i>=-4.10, <i>p</i>=4.24 × 10^-5), Desikan atlas pars opercularis (<i>T</i>=-4.21, <i>p</i>=2.55 × 10^-5), and DKT atlas pars opercularis (<i>T</i>=-3.96, <i>p</i>=7.47 × 10^-5). Subsequent MR analysis further demonstrated a causally protective effect of larger cortical area in the prefrontal operculum against the risk of developing chronic pain (OR = 0.91, <i>p</i>=1.91 × 10^-2). These results indicate a critical role of the surface area of frontal operculum in individual chronic pain susceptibility and provide a potential risk predictor for chronic pain development.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"4687197"},"PeriodicalIF":2.5,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Multimodal Pain Therapy Concept Including Intensive Physiotherapy on the Perception of Pain and the Quality of Life of Patients With Chronic Back Pain: A Prospective Observational Multicenter Study Named \"RütmuS\".","authors":"Katharina Zaglauer, Andrea Kunsorg, Vanessa Jakob, Lara Görg, Arndt Oehlschlägel, Rainer Riedel, Ursula Marschall, Dieter Welsink, Horst Schuhmacher, Maria Wittmann","doi":"10.1155/prm/6693678","DOIUrl":"10.1155/prm/6693678","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Question and Outcome Measures:&lt;/b&gt; In this study, an intervention group (multimodal therapy for chronic back pain) and a control group (standard outpatient treatment) were compared with regard to the primary endpoint of pain (NRS) at rest and the secondary endpoints pain (NRS) during movement, general health status (Short Form 12 (SF-12)), health-related quality of life (EQ-5D-5L), pain disability index (PDI), Hospital Anxiety and Depression Scale-Germany (HADS-D), and Hannover Functional Ability Questionnaire for Measuring Back Pain-Related Disability (FFbH-R). &lt;b&gt;Design and Participants:&lt;/b&gt; The total patient cohort of this prospective observational multicenter study consisted of 477 patients who were initially enrolled in the study from January 2019 to September 2020. &lt;b&gt;Intervention:&lt;/b&gt; The intervention group received physiotherapy, pain therapy (pain-therapeutic, body-related, and patient-specific treatment), and control examinations from the responsible physician in a 6-month structured interdisciplinary program. The evaluation points used in the analysis are the baseline survey, 6 months and 12 months after the start of the study. &lt;b&gt;Results:&lt;/b&gt; A total of 477 patients (243 in the intervention group and 234 in the control group) were included in the analysis; 42 patients in the intervention group deviated from the eligibility criteria due to insufficient adherence to study participation. Nonetheless, they were included in the analysis in line with the ITT principle. The primary endpoint, pain at rest (NRS), showed greater reductions in the intervention group compared to the control group, with mean differences of -0.492 (95% CI: [-0.866, -0.118], &lt;i&gt;p&lt;/i&gt; = 0.010) at 6 months (EVA 3) and -0.463 (95% CI: [-0.837, -0.089], &lt;i&gt;p&lt;/i&gt; = 0.015) at 12 months (EVA 5), respectively. Regarding the secondary endpoints, pain during movement exhibited a significantly greater reduction in the intervention group compared to the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Quality of life, measured via the EQ-5D-5L index, improved significantly more in the intervention group than in the control group, as did functional capacity (FFbH-R) and physical health (SF-12 KSK) (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). In contrast, mental health (SF-12 PSK) declined significantly during the intervention (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Disability (PDI) exhibited a significantly greater reduction in the intervention group compared to the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), whereas anxiety and depression levels (HADS-D) showed only slight changes in both groups, with anxiety being significant at &lt;i&gt;p&lt;/i&gt; = 0.0164 and depression not significant at &lt;i&gt;p&lt;/i&gt; = 0.1093. These results underscore the intervention's effectiveness across multiple health dimensions, particularly pain reduction and quality of life. &lt;b&gt;Conclusion:&lt;/b&gt; Multimodal pain therapy over a 6-month period is an effective intervention to improve the perception of pain at rest and during movement while enhancing the subjective quality of life","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"6693678"},"PeriodicalIF":2.5,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Latent Profiles of Healthy Adults' Biopsychosocial Pain Concepts.","authors":"Catherina Lenhof, Laura Dukek, Linda Wickering, Lena Hitschler, Michael Schneider, Tanja Hechler","doi":"10.1155/prm/5706849","DOIUrl":"10.1155/prm/5706849","url":null,"abstract":"<p><p><b>Objectives:</b> To develop effective, individualized pain science education for people with chronic (primary) pain, underlying pain concepts, defined as the understanding of what pain is, what function it serves, and what processes are thought to underpin it, are essential. Pain concepts and misconcepts of chronic pain can influence its development and maintenance. This study explores whether profiles of healthy adults' biopsychosocial pain concepts can be identified using a newly developed tool, the <i>biopsychosocial pain concept matrix</i> (BiPS matrix), and if adults assigned to the profiles differ regarding sociodemographic and pain-related variables. <b>Methods:</b> <i>N</i> = 229 healthy adults (75% female, <i>M</i> = 22.66 years, SD = 3.61) participated in an online survey. The BiPS matrix assesses biopsychosocial pain concepts through 40 items on the biological, psychological, and social domains combined with the five content dimensions of the common-sense model of self-regulation. <b>Results:</b> A latent profile analysis (LPA) revealed a five-profile solution with distinct patterns of biopsychosocial pain concepts. Participants assigned to Profile 1 demonstrated strongly developed biopsychosocial pain concepts, Profile 2 showed weakly developed concepts, and Profiles 3 to 5 showed different levels of pain concepts. General and neurophysiological pain knowledge differed between profiles, with higher scores being associated with Profile 1 and lower scores with Profile 5. There were no differences in sociodemographic variables in adults assigned to the different profiles. <b>Discussion:</b> Results provide preliminary evidence for distinct profiles of biopsychosocial pain concepts among healthy adults. Further research should replicate these findings in clinical samples to better understand biopsychosocial pain concepts and their use for individualized pain science education.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2025 ","pages":"5706849"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}