Pathogens and Global Health最新文献

{"title":"Diagnostic performance of hemozoin-based magneto-optical detection assay and RDT: a prospective observational study.","authors":"Vishnu Teja Nallapati, Manoj A R, Sushma Belurkar, Naveenchandra Kulal, Prashanth Bhat, Shama Prasada K, Nitin Gupta, Manjunath H Hande, Priyaleela Thota, David Bell, Kavitha Saravu","doi":"10.1080/20477724.2025.2551508","DOIUrl":"10.1080/20477724.2025.2551508","url":null,"abstract":"<p><p>Early detection and effective management of malaria are crucial for elimination efforts. Microscopy and rapid diagnostic tests (RDTs) have been the main diagnostic methods for over fifteen years, but they have limitations, especially in cases of low parasite density or deletions of target markers (HRP2/3). This study compares the diagnostic performance of a novel hemozoin-based diagnostic assay (Hz-MOD) with RDTs for detecting malaria in febrile patients in southwestern India. A prospective observational study involved 480 patients screened with Hz-MOD, RDT, microscopy, and nested PCR. Among the samples, 121 were positive by both microscopy and PCR. The sensitivity of Hz-MOD was 94.21% compared to microscopy and 91.74% compared to PCR. For RDTs, sensitivity was 90.91% compared to microscopy and 87.60% compared to PCR. In terms of specificity, Hz-MOD showed 98.61% compared to microscopy and 97.77% compared to PCR, while RDTs had 100% specificity against microscopy and 98.89% against PCR. These results suggest that the hemozoin-based test demonstrates similar sensitivity to RDTs and could serve as an effective screening tool for malaria detection.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"311-320"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12642893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefinition of transmission clusters by accessing to additional diversity in <i>Mycobacterium tuberculosis</i> through long-read sequencing.","authors":"Sergio Buenestado-Serrano, Silvia Vallejo-Godoy, Francisca Escabias Machuca, Pilar Barroso, Miguel Martínez-Lirola, Teresa Cabezas, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma","doi":"10.1080/20477724.2025.2555926","DOIUrl":"10.1080/20477724.2025.2555926","url":null,"abstract":"<p><p>Whole-genome sequencing, supported on short-read-sequencing, has revolutionized the precision to track <i>Mycobacterium tuberculosis</i> (MTB) transmission. However, the complexity of the MTB genome (10% repetitive regions and 65% GC content) challenges short-read mapping and assembly, leading to the exclusion of certain genomic regions from the analysis. Long-read sequencing can overcome these limitations, giving access to these regions, generally uninterrogated. Our study aims to evaluate the potential of long-read sequencing in redefining long-term MTB transmission clusters, previously characterized by short-read sequencing. We selected 78 cases from eight long-term clusters (5-17 years; 7 to 16 cases), from a population-based genomic epidemiology program in Almería, Spain. The clusters were carefully selected to ensure cases i) infected by identical strains (0 SNPs), ii) exhibiting pairwise-SNP-based distances from 1 to 16 SNPs and iii) distributed along different branches in the genomic networks. Long-read analysis increased the distances of each cluster from the reference by an average of 258 SNPs and intercluster distances by 113 SNPs. Within-cluster diversity also increased, with pairwise distances rising from 1 to 22 SNPs across 1-7 network branches. In one cluster, the acquisition of diversity led to overpass the 12-SNP threshold to consider a transmission cluster. Additionally, in four clusters, 1-2 cases previously classified as infected by identical strains were now reclassified due to the identification of additional SNP differences. Thanks to the identification of new diversity between the cases we could identify index cases, reconstruct transmission chronologies, precise patient-to-patient relationships and propose new epidemiological interpretations among the cases in cluster.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"321-331"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12642902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chikungunya and the forgotten lesson of COVID-19: where is the data?","authors":"Francesco Branda, Giancarlo Ceccarelli, Davide Zella, Francesca Benedetti, Fabio Scarpa, Massimo Ciccozzi","doi":"10.1080/20477724.2025.2566063","DOIUrl":"10.1080/20477724.2025.2566063","url":null,"abstract":"","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"351-352"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12642880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupting vector competence: exploring radiofrequency exposure as a novel approach to mosquito-borne disease prevention in a changing climate.","authors":"Francesco Defilippo, Ana Moreno, Massimo Ciccozzi, Margherita Losardo, Pietro Bia, Antonio Manna, Laura de Gara, Marta Giovanetti","doi":"10.1080/20477724.2025.2573317","DOIUrl":"10.1080/20477724.2025.2573317","url":null,"abstract":"<p><p>The global expansion of mosquito-borne diseases such as dengue, chikungunya, Zika, and West Nile virus is a major public health concern, intensified by climate change and environmental alterations. <i>Aedes aegypti</i>, <i>Aedes albopictus</i>, and <i>Culex pipiens</i> are among the most important vectors for these pathogens, contributing to their transmission across increasingly broad geographic areas. In Europe, the expanding distribution and vectorial competence of <i>Ae. albopictus</i> and <i>Cx. pipiens</i> highlight the need for innovative control strategies beyond traditional chemical and mechanical interventions, which face growing limitations due to resistance and sustainability concerns. This review examines the potential of radiofrequency (RF) exposure as a novel method to disrupt mosquito development and reduce vector competence. While the biological effects of RF have been studied in other systems, its impact on mosquito physiology and pathogen transmission remains underexplored. Preliminary findings suggest that RF exposure may alter larval viability, adult emergence, and reproductive capacity, with possible downstream effects on pathogen replication and transmission. We contextualize RF-based approaches alongside other emerging biocontrol strategies, including <i>Wolbachia</i>-based methods, genetic modification, and sterile insect techniques, emphasizing their integration into climate-responsive vector control programs. Additional consideration is given to other arthropod vectors of medical relevance, such as sandflies (<i>Phlebotominae</i>) and biting midges (<i>Culicoides</i> spp.), which contribute to the spread of arboviruses. Finally, we identify research gaps and propose directions for interdisciplinary studies to evaluate the feasibility, efficacy, and ecological impact of RF-based interventions. By targeting mosquito competence through non-chemical, scalable technologies, RF exposure offers a promising avenue to strengthen arbovirus prevention in the context of climate-driven vector expansion.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"343-350"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic and epidemiological characteristics of <i>Shigella boydii</i> in Australia, 1991-2022.","authors":"Aaliya F Ibrahim, Danielle J Ingle, Jessica R Webb, Benjamin P Howden, Patiyan Andersson, Benjamin G Polkinghorne, Rose Wright, Kathryn Glass, Martyn D Kirk","doi":"10.1080/20477724.2025.2573308","DOIUrl":"10.1080/20477724.2025.2573308","url":null,"abstract":"<p><p>Shigellosis is a leading cause of diarrheal mortality worldwide. <i>Shigella boydii</i> is one of four <i>Shigella</i> species that contributes to this burden, however studies on <i>S. boydii</i> are limited. Here we combined epidemiological and genomic data to better understand <i>S. boydii</i> circulating both in Australia and globally. Between 1991 and 2019, there were 294 cases of <i>S. boydii</i> infections notified to the National Notifiable Diseases Surveillance System by Australian states and territories, with an increasing trend in notifications observed from 2013. Of cases whose place of acquisition was known, 54% (111/206) were acquired overseas, mainly from South-East Asia (57%; 63/111). Our genomic analysis included 250 <i>S. boydii</i> isolates: 44 from Victoria, Australia spanning 22 years (2001-2022) and 206 international isolates spanning 91 years (1930-2020). Phylogenomic analyses identified five major <i>S. boydii</i> phylogenetic lineages circulating globally. The Australian isolates were distributed across all five lineages, but the highest proportion was in Lineage 3. Antimicrobial resistance was common in both international and Australian isolates with > 60% of isolates classified as multi-drug-resistant. Resistance to the main clinically relevant antimicrobials was rare in <i>S. boydii</i>. Ciprofloxacin resistance was detected in seven <i>S. boydii</i>, however reduced susceptibility to ciprofloxacin was detected in 56 isolates and found in both Australian and international data. Importantly, resistance mechanisms to third-generation cephalosporins and macrolides were also detected. This study is the largest genomic analysis of <i>S. boydii</i> to date, providing insights into the population structure, epidemiology and emerging AMR threats in this neglected <i>Shigella</i> species.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"332-342"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12897542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza strains in focus: global approaches to the diagnosis, treatment, and control of H1N1, H3N2, H7N9, and H9N2.","authors":"Amandeep Singh, Prabhjot Kaur, Manish Kumar, Rohit Bhatia, Sheeba Shafi, Prabhat Kumar Upadhyay, Ashish Gaur, Abhishek Tiwari, Varsha Tiwari","doi":"10.1080/20477724.2025.2536906","DOIUrl":"10.1080/20477724.2025.2536906","url":null,"abstract":"<p><p>Influenza virus and its various strains are a significant risk for the global health; influenza and its various strains have caused various periodic outbreaks and pandemics. As we delve into this review, it studies the history and the threat possessed by the four prominent strains of influenza H1N1, H3N2, H7N9, and H9N2. It also examines some of recent and notable outbreaks posed by these influenza strains. In 2009, the H1N1 pandemic was originated in the swine and was spread worldwide rapidly. This outbreak highlighted the gaps in the preparations and response in global healthcare system. The other strain H3N2 with a long history of frequent outbreaks distresses the public health and the health care sectors due to its evolution and the ability to adapt. In 2013 China, a novel strain was identified with a high mortality rate and the potential for human-to-human transmission remains a concern to the public health. Another strain H9N2 though less infectious is being monitored for its ability to cause pandemics in the future, and its distinct genetic makeup and sporadic human infections are causes for worry. This review outlines their differences and similarities, the importance of vigilant surveillance, effective treatment strategies, and the preparedness measures to mitigate any future influenza outbreaks.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"272-292"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and regional mortality rate statistics of mpox (formerly monkeypox): a comprehensive systematic review and meta-analysis.","authors":"Srivatsa Surya Vasudevan, Tiba Yamin Kandrikar, Prachi Cooner, Bijay Mukesh Jeswani, Suhel F Batarseh, Abdalla Sayed, Ashmita Yadav, Aakanksha Pitliya, Vijay Kumar, Riddhi Panchal, Abhishek Vasudevan, Chun Li, Hansala Nursah Yilmaz Tuna, Kartik Dapke, Piyush Gondaliya","doi":"10.1080/20477724.2025.2551507","DOIUrl":"10.1080/20477724.2025.2551507","url":null,"abstract":"<p><p>The mortality trends associated with the mpox virus (MPXV) are not well defined. This study aims to systematically assess the mortality rate of mpox and its stratification across different geographical locations. Comprehensive review of articles from the PubMed, Embase, Scopus, and Web of Science databases up to June 2025, focusing on studies reporting mortality rates among patients diagnosed with mpox. A random-effects proportional meta-analysis assessed global and regional mpox mortality rates and their geographical variations. Sensitivity analysis using one-study removal method and meta-regression analyses were conducted. Out of 4,098 records, 30 articles met the selection criteria, comprising a total of 47,311 patients diagnosed with mpox. The pooled global mpox mortality rate was 3.1% (95% CI: 1.6%-5.9%). Mortality was significantly higher before 2016 at 11.4% (95% CI: 5.8%-21.1%), compared to 2.4% (95% CI: 1.2%-4.7%) during 2016-2025, and declined further in the post-COVID era to 1.5% (95% CI: 0.7%-3.4%). Mortality was markedly elevated among individuals with HIV co-infection (83.8%; 95% CI: 74.0%-90.5%). Regionally, mortality was highest in Africa (6.3%) and lowest in Europe (0.1%). Among studies conducted in endemic regions, a notable temporal decline was also observed, with mortality decreasing from 11.4% before 2016 to 4.1% during 2016-2025. Meta-regression identified year of publication as a significant predictor of mortality (<i>p</i> = 0.028), indicating improved outcomes over time. Global mpox mortality has declined over time, particularly in endemic regions and the post-COVID era. However, individuals with HIV remain at exceptionally high risk, underscoring the need for targeted interventions.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"293-303"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of severe COVID-19 in vaccinated adults: a study from southern Brazil (2021-2023).","authors":"Guilherme Geraldo Lovato Sorio, Vinicius da Silva Gregory, Daniel Sganzerla, Marcelo Rodrigues Gonçalves, Fabio Fernandes Dantas Filho, Maria Helena da Silva Pitombeira Rigatto","doi":"10.1080/20477724.2025.2554138","DOIUrl":"10.1080/20477724.2025.2554138","url":null,"abstract":"<p><p>Despite the effectiveness of vaccination in preventing severe COVID-19, some individuals remain at risk. The study goal was to determine risk factors for COVID-19 requiring hospital admission. A case-control study was conducted in Porto Alegre, Brazil. Vaccinated adults with confirmed SARS-CoV-2 infection from February 2021 to March 2023 were eligible. Hospitalized patients (cases) and outpatients with non-severe infections (control group) were time-matched in a 1:1 ratio. Moreover, we followed hospitalized patients (cases) to evaluate factors related to 30-day mortality and/or ventilation support. We included 364 patients: 182 cases and 182 controls. Age > 60 years (odds ratio [OR] 3.98 [95% confidence interval{CI} 2.23-7.19]), male sex (OR 3.07 [95%CI 1.78-5.40]), diabetes mellitus (OR 4.61 [95% CI 2.08-11.08]), cardiovascular disease (OR 4.07 [95%CI 1.73-10.64]), lung disease (OR 3.06 [95%CI 1.39-6.94]), obesity (OR 3.39 [95%CI 1.29-9.73]), and previous infection (OR 0.19 [95%CI 0.06-0.51]) were independently related to COVID-19 hospital admission. In the arm of hospitalized patients, the number of vaccine doses (OR 0.53 [95%CI 0.39-0.73]) was a protective factor against 30-day mortality and/or ventilation support, whereas obesity (OR1.62 [95%CI 1.19-2.20]) was a risk factor. Health policies should consider focusing on these risk populations for targeted interventions, such as additional boosters, early treatment and prophylaxis.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"235-242"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New enemies: contribution of C<i>ulex perexiguus</i> in the transmission dynamic of West Nile virus.","authors":"Elisa Fesce, Martina Ferraguti","doi":"10.1080/20477724.2025.2538838","DOIUrl":"10.1080/20477724.2025.2538838","url":null,"abstract":"<p><p>Vector-borne pathogens like West Nile virus (WNV), an emerging zoonotic arbovirus, are strongly influenced by mosquito community dynamics. WNV is maintained between birds and mosquitoes, with humans and other mammal species (such as equids) as dead-end hosts. In Spain, the role of <i>Culex perexiguus</i> as main vector of WNV is gaining significance over <i>Cx. pipiens</i> due to differences in feeding behavior, and vector competence, and ecological preferences that affect WNV transmission. Using a SEIR (Susceptible-Exposed-Infectious-Recovered) model, we examined how mosquito abundance and feeding preferences impact WNV spread in a Mediterranean region. Our results suggest that, under the conditions simulated, <i>Cx. pipiens</i> alone is unlikely to sustain WNV transmission in the study area, whereas <i>Cx. perexiguus</i> may contribute more substantially to outbreak dynamics. Increased avian-feeding preferences were associated with higher outbreak intensity, although the basic reproduction number (<i>R</i>_<i>0</i>) remained below one in all scenarios. Sensitivity analyses highlighted that bite rates and abundance of <i>Cx. perexiguus</i> are key drivers of WNV spread in our model. Furthermore, a dilution effect was observed when <i>Cx. pipiens</i> fed more frequently on dead-end hosts, which contributed to lowering <i>R</i>_<i>0</i>. Our findings underscore the need for species-specific vector surveillance to inform public health interventions and control strategies for WNV and other mosquito-borne diseases.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"243-258"},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of oral human papillomavirus infection in African countries: a systematic review and meta-analysis.","authors":"Giorgia Della Polla, Grazia Miraglia Del Giudice, Mario Postiglione, Italo Francesco Angelillo","doi":"10.1080/20477724.2025.2529822","DOIUrl":"10.1080/20477724.2025.2529822","url":null,"abstract":"<p><p>This meta-analysis aimed to provide pooled overall prevalence estimates of oral human papillomavirus (HPV) infection in Africa. A literature search for cross-sectional studies was conducted until January 2025. The Newcastle-Ottawa Scale assessed the methodological quality. Random-effects model estimated the pooled prevalence of oral HPV infection. Sub-group analyses were conducted using study characteristics as covariates. Thirty-three studies involving 4.607 participants from 9 countries were included. Prevalence of oral HPV infection ranged between 0% to 95.1%, with a pooled overall estimate of 15.8%. The studies exhibited considerable heterogeneity (I2 = 99.3%). Subgroup analyses revealed the highest prevalence among participants with head and neck cancer (19.9%), from sub-Saharan area (19.2%), female (17.3%), moderate-low-quality studies (16.7%), and in HIV-positive (5.8%). High-quality studies with an accurate collection of the risk factors are needed for tailoring programs and health-care policies to prevent and control oral HPV infection and associated diseases.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"259-271"},"PeriodicalIF":3.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}