Beyond gain of function: strengthening oversight of research with potential pandemic pathogens.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2024-05-01 Epub Date: 2023-10-04 DOI:10.1080/20477724.2023.2265627
Gregory D Koblentz, Rocco Casagrande
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引用次数: 0

Abstract

In 2017, the Department of Health and Human Services adopted a policy, known as the P3CO Framework, to govern proposed research that could enhance the lethality or transmissibility of a potential pandemic pathogen. The prospect of a human-made virus with artificially enhanced lethality and transmissibility has raised serious biosafety and biosecurity concerns. The COVID-19 pandemic has generated new concerns about the risks posed by such research. Even if the origins of the pandemic are presumed or proven to be the result of a natural zoonotic spillover event, the pandemic has placed greater scrutiny on research that could generate pandemic-capable viruses and dramatically illustrated the consequences if such a virus were released from a laboratory. This article assesses the strengths and weaknesses of the P3CO Framework and provides recommendations for strengthening oversight of research with potential pandemic pathogens. The P3CO Framework should be replaced by a national policy that would apply to all relevant research, regardless of the source of funding and be implemented by a new national agency for biorisk management. This new policy would need to be accompanied by a comprehensive analysis of potential pandemic pathogen risks, clear guidance on how to identify research that falls within the scope of the policy, a rigorous process for reviewing the risks and benefits of such research, and criteria for determining the appropriate measures needed to conduct such research safely, securely, and responsibly.

超越功能获得:加强对潜在流行病病原体研究的监督。
2017年,卫生与公众服务部通过了一项被称为P3CO框架的政策,以管理可能提高潜在大流行病原体致命性或传播性的拟议研究。人工增强致命性和传播性的人造病毒的前景引发了严重的生物安全和生物安保问题。新冠肺炎大流行引发了人们对此类研究带来的风险的新担忧。即使大流行的起源被推测或证明是自然人畜共患外溢事件的结果,但这场大流行对可能产生具有大流行能力的病毒的研究进行了更严格的审查,并戏剧性地说明了如果这种病毒从实验室释放会产生什么后果。本文评估了P3CO框架的优势和劣势,并为加强对潜在流行病病原体研究的监督提供了建议。P3CO框架应被适用于所有相关研究的国家政策所取代,无论资金来源如何,并由一个新的国家生物风险管理机构实施。这项新政策需要对潜在的大流行病原体风险进行全面分析,就如何确定属于该政策范围的研究提供明确指导,审查此类研究的风险和益处的严格程序,以及确定安全、可靠和负责任地进行此类研究所需的适当措施的标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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