Pathogens and Global Health最新文献

Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature. 肝血吸虫病是导致肝肉芽肿和肝纤维化的决定性因素：现有文献综述。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-13 DOI: 10.1080/20477724.2024.2400033

Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J

{"title":"Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature.","authors":"Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J","doi":"10.1080/20477724.2024.2400033","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400033","url":null,"abstract":"Hepatic schistosomiasis is a neglected parasitosis that affects millions of people each year worldwide and leads to high healthcare costs and increased morbidity and mortality in infected humans. It is a disease that has been widely studied in terms of its pathophysiology; therefore, the signaling pathways that lead to liver damage, with the consequent development of liver fibrosis, are now better understood. Research has elucidated the role of soluble egg antigen in the development of hepatic granulomas and liver fibrosis, the signal transducer and activator of transcription 3 and its participation in liver damage, the role of heat shock protein 47 and its involvement in liver fibrosis, the anti-inflammatory effects caused by interleukin-37, and the role of natural killer and natural killer T cells in the development of the disease. Hepatic schistosomiasis can range from simple hepatomegaly to the development of portal hypertension combined with hepatic fibrosis. For diagnostic purposes, a microscopic examination of excreta remains the gold standard; however, abdominal ultrasound has recently taken on an important role in the assessment of liver lesions produced by the parasite. Praziquantel is considered the management drug of choice, and has been associated with a potential preventive antifibrotic effect.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic diversity, variation and recombination among the human papillomaviruses (HPVs) genomes isolated in China: a comparative genomic and phylogenetic analysis 中国分离的人乳头瘤病毒（HPV）基因组的遗传多样性、变异和重组：基因组和系统发育比较分析

IF 3.4 4区医学

Pathogens and Global Health Pub Date : 2024-09-12 DOI: 10.1080/20477724.2024.2401273

Pir Tariq Shah, Zhenyong Wu, Ruilan Ma, Chengjun Wu

引用次数: 0

The first molecular record of Borrelia afzelii, B. garinii, B. valaisiana, B. burgdorferi s.s. and B. bavariensis in Bosnia and Herzegovina 在波斯尼亚和黑塞哥维那首次发现阿夫泽尔氏包柔氏菌、加里宁氏包柔氏菌、瓦莱西亚氏包柔氏菌、勃氏包柔氏杆菌和巴伐利亚氏包柔氏菌的分子记录

IF 3.4 4区医学

Pathogens and Global Health Pub Date : 2024-09-10 DOI: 10.1080/20477724.2024.2399380

Lejla Ušanović, Lejla Lasić, Naris Pojskić, Dalila Destanović, Jasna Hanjalić Kurtović, Belma Kalamujić Stroil

引用次数: 0

Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study. 一项横断面研究：4 岁及以上急性呼吸道感染儿童的百日咳博德特氏菌感染率。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-08 DOI: 10.1080/20477724.2024.2400412

Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan

{"title":"Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study.","authors":"Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan","doi":"10.1080/20477724.2024.2400412","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400412","url":null,"abstract":"Introduction and aim: In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of Bordetella pertussis and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.Methods: This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. B. pertussis was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.Results: Children (n = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of B. pertussis (n = 2/298, 0.67%) were detected. Both children were also co-infected with Bordetella spp. The majority of the patients (n = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.Conclusion: The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network. 回顾与肠道病毒相关的手足口病：预防策略和建立全球肠道病毒监测网络的必要性。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-04 DOI: 10.1080/20477724.2024.2400424

Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen

{"title":"A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network.","authors":"Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen","doi":"10.1080/20477724.2024.2400424","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400424","url":null,"abstract":"Enterovirus (EV)-associated hand, foot, and mouth disease (HFMD) is a significant public health issue worldwide, commonly occurring in children five years of age or younger. The leading causes of most HFMD cases are EVs, which are members of the Picornaviridae family. The typical clinical manifestations of EV-associated HFMD are febrile presentations with mucosal herpangina, oral ulcerations, and skin rashes on the hands and feet. The majority of HFMD cases resolve without consequence; however, a subset progresses to severe neurological and cardiopulmonary complications, which can be fatal. In the past two decades, EV-associated HFMD has received significant attention. In this review, we organize published papers and provide updates on epidemiology, pathogenesis, surveillance, and vaccine developments for EV-associated HFMD. The impact of EV-associated HFMD is increasing globally. Developing efficacious vaccines has become a priority for preventing EV infections without adequate treatment. Simultaneously, emerging EV infections (including EV-D68, EV-A71, Coxsackieviruses, and echoviruses) are increasing, highlighting the need to create a vigilant surveillance system for EV infections worldwide.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever. 评估克里米亚-刚果出血热患者的 YKL-40 水平与临床严重程度之间的关系。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1080/20477724.2024.2392225

Murat Aydin, Nurten Nur Aydin, Esra Laloğlu

{"title":"Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever.","authors":"Murat Aydin, Nurten Nur Aydin, Esra Laloğlu","doi":"10.1080/20477724.2024.2392225","DOIUrl":"10.1080/20477724.2024.2392225","url":null,"abstract":"Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne viral disease. YKL-40 (also known as chitinase-3-like-1 protein) is an acute phase protein released by various immune cells. The purpose of this study was to investigate the relationship between YKL-40 level and the clinical course and prognosis of CCHF. The study included 78 patients who were admitted to our hospital between April 15 and 30 August 2022 and had a positive polymerase chain reaction test result for CCHF. The patients were divided into two groups, severe and non-severe. In addition, a control group consisting of 22 healthy people was established. Mean serum YKL-40 levels were significantly higher in patients than controls (106.8 ng/mL ± 91.2 and 47.1 ng/mL ± 35.3, respectively; p < 0.001). However, mean YKL-40 levels were also significantly higher in patients with severe CCHF compared to non-severe cases (173.3 ± 112.3 and 67.5 ± 41.7, respectively; p < 0.001). A comparison of the 10 exitus patients and the 68 survivors revealed significantly higher YKL-40 levels in the exitus group (mean: 214.0 ± 139.0 and 92.8 ± 73.6, respectively; p = 0.001). A receiver operating characteristic analysis for YKL-40 levels to distinguish between severe and non-severe patients found an area under the curve of 0.925. YKL-40 levels were measured with a sensitivity of 97% and a specificity of 84% with a cutoff value of 90.7 ng/mL. YKL-40 levels measured at the time of hospital presentation in patients with CCHF can be used as a biomarker for clinical course and prognosis.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis. 1994 年至 2023 年全球和地区尼帕病毒死亡率统计：全面系统回顾和荟萃分析。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1080/20477724.2024.2380131

Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya

{"title":"Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis.","authors":"Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya","doi":"10.1080/20477724.2024.2380131","DOIUrl":"10.1080/20477724.2024.2380131","url":null,"abstract":"The mortality rate of Nipah virus (NiV) can vary in different regions, and its pattern across timelines has yet to be assessed. The primary objective is to perform a comparative analysis of mortality rates across different timelines and countries. Articles reporting NiV mortality from inception to November 2023 were analyzed in PubMed, Ovid Embase, Scopus, and Web of Science databases. A meta-analysis utilizing random-effects models determined the mortality rate secondary to NiV complications. The initial search strategy yielded 1213 records, of which 36 articles met the inclusion criteria, comprising 2736 NiV patients. The Global mortality rate of the Nipah virus in the 2014-2023 decade was 80.1% (CI: 68.7-88.1%), indicating a significant 24% increase compared to the preceding decade (2004-2013) with a mortality rate of 54.1% (CI: 35.5-71.6%). Among the countries analyzed for overall mortality from 1994-2023, India experienced the highest mortality rate at 82.7% (CI: 74.6-88.6%), followed by Bangladesh at 62.1% (CI: 45.6-76.2%), Philippines at 52.9% (CI: 30-74.5%), Malaysia at 28.9% (CI: 21.4-37.9%), and Singapore at 21% (CI: 8-45%). Subgroup analysis revealed that India consistently had the highest mortality rate for the past two decades (91.7% and 89.3%). The primary complication leading to mortality was encephalitis, accounting for 95% of cases. This systematic review and meta-analysis revealed a noteworthy surge in NiV mortality rates, particularly in the current decade (2014-2023). The escalation, with India reporting a concerning level of mortality of 89.3-91.7% in the past decades, signifies a pressing public health challenge.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JN.1 and the ongoing battle: unpacking the characteristics of a new dominant COVID-19 variant. JN.1 和正在进行的战斗：解读 COVID-19 新变种的特征。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1080/20477724.2024.2369378

Reza Eshraghi, Ashkan Bahrami, Motahare Karimi Houyeh, Maryam Nasr Azadani

引用次数: 0

Malaria diagnosis challenges and pfhrp2 and pfhrp3 gene deletions using pregnant women as sentinel population in Nanoro region, Burkina Faso. 以布基纳法索纳诺罗地区的孕妇为哨点人群进行疟疾诊断的挑战与 pfhrp2 和 pfhrp3 基因缺失。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1080/20477724.2024.2388489

Irene Molina-de la Fuente, Marc Christian Tahita, Kabore Bérenger, Thuy Huong Ta Tang, Luz García, Vicenta González, Agustín Benito, Judith M Hübschen, Halidou Tinto, Pedro Berzosa

{"title":"Malaria diagnosis challenges and pfhrp2 and pfhrp3 gene deletions using pregnant women as sentinel population in Nanoro region, Burkina Faso.","authors":"Irene Molina-de la Fuente, Marc Christian Tahita, Kabore Bérenger, Thuy Huong Ta Tang, Luz García, Vicenta González, Agustín Benito, Judith M Hübschen, Halidou Tinto, Pedro Berzosa","doi":"10.1080/20477724.2024.2388489","DOIUrl":"10.1080/20477724.2024.2388489","url":null,"abstract":"Malaria in pregnancy causes adverse consequences and prompt and accurate diagnosis is essential for case management. In malaria endemic countries, diagnosis is mainly based on rapid diagnostic tests (RDT) and microscopy. However, increasing reports of false negatives caused by low parasitemia and pfhrp2/3 deletions raise concerns about HRP2-based RDT usefulness. This study aimed to assess RDT and microscopy performance and to describe pfhrp2/3 deletions in a cohort of 418 pregnant women in Burkina Faso. Malaria was diagnosed using RDT and microscopy and blood samples were collected during antenatal care visits. Diagnostic results were compared to PCR as gold standard. Pfhrp2 and pfhrp3 deletions were characterized for patients with confirmed P. falciparum infection. RDT had better sensitivity (76%) but lower specificity (83%) than microscopy (sensitivity = 57%; specificity = 98%). Low parasitemia (<150 parasites/µL), especially in multigravidae, was the principal factor causing false negatives by both methods. Moreover, pfhrp2 deletion frequency among overall false negatives by RDT was 21.43%. Higher frequency of deletions was found among all samples, independently of RDT result, for example around 2% of samples had double deletions meaning that the majority of deletions had no effect on RDT testing. Finally, it was found higher pfhrp2 deletion in women with lower uterine height during the first trimester. Wider and National surveillance study of deletions is recommended among pregnant women and in Burkina Faso.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical biosensors for the detection of protozoan parasite: a scoping review. 用于检测原生动物寄生虫的电化学生物传感器：范围综述。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1080/20477724.2024.2381402

Syahrul Amin Sa'adon, Nur Hana Jasni, Hairul Hisham Hamzah, Nurulhasanah Othman

{"title":"Electrochemical biosensors for the detection of protozoan parasite: a scoping review.","authors":"Syahrul Amin Sa'adon, Nur Hana Jasni, Hairul Hisham Hamzah, Nurulhasanah Othman","doi":"10.1080/20477724.2024.2381402","DOIUrl":"10.1080/20477724.2024.2381402","url":null,"abstract":"The development of rapid, accurate, and efficient detection methods for protozoan parasites can substantially control the outbreak of protozoan parasites infection, which poses a threat to global public health. Idealistically, electrochemical biosensors would be able to overcome the limitations of current detection methods due to their simplified detection procedure, on-site quantitative analysis, rapid detection time, high sensitivity, and portability. The objective of this scoping review is to evaluate the current state of electrochemical biosensors for detecting protozoan parasites. This review followed the most recent Preferred Reporting Items for Systematic Review and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) recommendations. Using electrochemical biosensor and protozoan parasite keywords, a literature search was conducted in PubMed, Scopus, Web of Science, and ScienceDirect on journals published between January 2014 and January 2022. Of the 52 studies, 19 were evaluated for eligibility, and 11 met the review's inclusion criteria to evaluate the effectiveness and limitations of the developed electrochemical biosensor platforms for detecting protozoan parasite including information about the samples, biomarkers, bioreceptors, detection system platform, nanomaterials used in fabrication, and limit of detection (LoD). Most electrochemical biosensors were fabricated using conventional electrodes rather than screen-printed electrodes (SPE). The range of the linear calibration curves for the developed electrochemical biosensors was between 200 ng/ml and 0.77 pM. The encouraging detection performance of the electrochemical biosensors demonstrate their potential as a superior alternative to existing detection techniques. On the other hand, more study is needed to determine the sensitivity and specificity of the electrochemical sensing platform for protozoan parasite detection.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0