Pathogens and Global Health最新文献

Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis. 2003 年至 2023 年沙特阿拉伯的登革热病毒感染情况：系统回顾和荟萃分析。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-11-07 DOI: 10.1080/20477724.2024.2425493

Ali A Rabaan, Amer Alshengeti, Hayam A Alrasheed, Maha F Al-Subaie, Maha H Aljohani, Yahya A Almutawif, Amjad A Yousuf, Shahab A Alsuliman, Jumana M Al-Jishi, Fareed Almalki, Maha A Alshiekheid, Hejji E Alahmed, Ameen M Alramadan, Safaa Abdulrahman Turkistani, Khalid Hajissa

{"title":"Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis.","authors":"Ali A Rabaan, Amer Alshengeti, Hayam A Alrasheed, Maha F Al-Subaie, Maha H Aljohani, Yahya A Almutawif, Amjad A Yousuf, Shahab A Alsuliman, Jumana M Al-Jishi, Fareed Almalki, Maha A Alshiekheid, Hejji E Alahmed, Ameen M Alramadan, Safaa Abdulrahman Turkistani, Khalid Hajissa","doi":"10.1080/20477724.2024.2425493","DOIUrl":"10.1080/20477724.2024.2425493","url":null,"abstract":"Dengue virus (DENV) remains one of the most common arboviral infections threatening humans. This study was conducted to systematically review the available literature and provide an updated overview of the overall prevalence of DENV infection in Saudi Arabia. The prevalence data was pooled from 21,891 participants recruited in 17 studies. Using random-effects model, the overall prevalence of DENV infection in Saudi Arabia was calculated as 30.8% (95% CI: 20.8-49.8%). The pooled IgM and IgG seroprevalence rates were 17.7% and 26.6%, respectively. Furthermore, the detection of DENV-NS1 antigen and viral RNA revealed pooled estimates of 16.4% and 37.0%, respectively. This study reports a relatively high burden of DENV infection in Saudi Arabia. The findings of this SRMA provide valuable information on the epidemiology of DENV infections in the country, highlighting the need for additional epidemiological investigations to assess the current situation of DENV infection in the country.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations. 针对不同曲霉菌种的免疫球蛋白 G 在诊断高危人群慢性肺曲霉菌病中的临床应用。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-11-06 DOI: 10.1080/20477724.2024.2424489

Li-Ta Keng, Chen-Chieh Lin, Chang-Wei Wu, Chia-Jung Liu, Lih-Yu Chang, Meng-Rui Lee, Jung-Yueh Chen, Jann-Yuan Wang

{"title":"Clinical applications of immunoglobulin G against different individual Aspergillus species for the diagnosis of chronic pulmonary aspergillosis among at-risk populations.","authors":"Li-Ta Keng, Chen-Chieh Lin, Chang-Wei Wu, Chia-Jung Liu, Lih-Yu Chang, Meng-Rui Lee, Jung-Yueh Chen, Jann-Yuan Wang","doi":"10.1080/20477724.2024.2424489","DOIUrl":"https://doi.org/10.1080/20477724.2024.2424489","url":null,"abstract":"Aspergillus fumigatus-specific IgG is often used as a diagnostic test for chronic pulmonary aspergillosis (CPA), but few studies have evaluated the performance and serology of IgGs from species other than A. fumigatus. In this study, we evaluated the serology and performance of different Aspergillus species-specific IgG antibodies in patients with CPA and at-risk populations and whether different Aspergillus species-specific IgGs could be of clinical utility and aid in the diagnosis of CPA caused by all Aspergillus species. A total of 187 participants were included between 2020 and 2022 (12 with CPA, 75 with old tuberculosis [TB], 45 with active TB and 55 with bronchiectasis). We measured the serum Aspergillus fumigatus, flavus, terreus, niger-specific, and mixed Aspergillus IgG levels (Phadia ImmunoCap). The correlation was the strongest between A. fumigatus and A. niger (Spearman's rank: 0.940), followed by A. niger and A. flavus (Spearman's rank: 0.915). A. terreus-specific IgG was less strongly correlated with the other three Aspergillus species-specific IgG (Spearman's rank: 0.828-0.849). A. flavus (4 of 6, 67%) was the dominant species. Using the at-least-one-positive approach, the highest performance was obtained when A. fumigatus and A. flavus IgGs were used (sensitivity, 0.75; specificity, 0.84). Significant cross-reactivity exists among different Aspergillus-species IgGs although the correlation may be less significant for A. terreus. In addition to the commonly used A. fumigatus IgG test, IgGs specific to local prevalent Aspergillus species may provide additional clinical utility.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature. 肝血吸虫病是导致肝肉芽肿和肝纤维化的决定性因素：现有文献综述。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-13 DOI: 10.1080/20477724.2024.2400033

Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J

{"title":"Hepatic schistosomiasis as a determining factor in the development of hepatic granulomas and liver fibrosis: a review of the current literature.","authors":"Lara-Cano R, Castañeda-Méndez P F, Uribe-Esquivel M, Barbero-Becerra V J","doi":"10.1080/20477724.2024.2400033","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400033","url":null,"abstract":"Hepatic schistosomiasis is a neglected parasitosis that affects millions of people each year worldwide and leads to high healthcare costs and increased morbidity and mortality in infected humans. It is a disease that has been widely studied in terms of its pathophysiology; therefore, the signaling pathways that lead to liver damage, with the consequent development of liver fibrosis, are now better understood. Research has elucidated the role of soluble egg antigen in the development of hepatic granulomas and liver fibrosis, the signal transducer and activator of transcription 3 and its participation in liver damage, the role of heat shock protein 47 and its involvement in liver fibrosis, the anti-inflammatory effects caused by interleukin-37, and the role of natural killer and natural killer T cells in the development of the disease. Hepatic schistosomiasis can range from simple hepatomegaly to the development of portal hypertension combined with hepatic fibrosis. For diagnostic purposes, a microscopic examination of excreta remains the gold standard; however, abdominal ultrasound has recently taken on an important role in the assessment of liver lesions produced by the parasite. Praziquantel is considered the management drug of choice, and has been associated with a potential preventive antifibrotic effect.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic diversity, variation and recombination among the human papillomaviruses (HPVs) genomes isolated in China: a comparative genomic and phylogenetic analysis 中国分离的人乳头瘤病毒（HPV）基因组的遗传多样性、变异和重组：基因组和系统发育比较分析

IF 3.4 4区医学

Pathogens and Global Health Pub Date : 2024-09-12 DOI: 10.1080/20477724.2024.2401273

Pir Tariq Shah, Zhenyong Wu, Ruilan Ma, Chengjun Wu

引用次数: 0

The first molecular record of Borrelia afzelii, B. garinii, B. valaisiana, B. burgdorferi s.s. and B. bavariensis in Bosnia and Herzegovina 在波斯尼亚和黑塞哥维那首次发现阿夫泽尔氏包柔氏菌、加里宁氏包柔氏菌、瓦莱西亚氏包柔氏菌、勃氏包柔氏杆菌和巴伐利亚氏包柔氏菌的分子记录

IF 3.4 4区医学

Pathogens and Global Health Pub Date : 2024-09-10 DOI: 10.1080/20477724.2024.2399380

Lejla Ušanović, Lejla Lasić, Naris Pojskić, Dalila Destanović, Jasna Hanjalić Kurtović, Belma Kalamujić Stroil

引用次数: 0

Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study. 一项横断面研究：4 岁及以上急性呼吸道感染儿童的百日咳博德特氏菌感染率。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-08 DOI: 10.1080/20477724.2024.2400412

Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan

{"title":"Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study.","authors":"Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan","doi":"10.1080/20477724.2024.2400412","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400412","url":null,"abstract":"Introduction and aim: In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of Bordetella pertussis and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.Methods: This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. B. pertussis was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.Results: Children (n = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of B. pertussis (n = 2/298, 0.67%) were detected. Both children were also co-infected with Bordetella spp. The majority of the patients (n = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.Conclusion: The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network. 回顾与肠道病毒相关的手足口病：预防策略和建立全球肠道病毒监测网络的必要性。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-04 DOI: 10.1080/20477724.2024.2400424

Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen

{"title":"A review of enterovirus-associated hand-foot and mouth disease: preventive strategies and the need for a global enterovirus surveillance network.","authors":"Chien-Yuan Huang, Shih-Bin Su, Kow-Tong Chen","doi":"10.1080/20477724.2024.2400424","DOIUrl":"https://doi.org/10.1080/20477724.2024.2400424","url":null,"abstract":"Enterovirus (EV)-associated hand, foot, and mouth disease (HFMD) is a significant public health issue worldwide, commonly occurring in children five years of age or younger. The leading causes of most HFMD cases are EVs, which are members of the Picornaviridae family. The typical clinical manifestations of EV-associated HFMD are febrile presentations with mucosal herpangina, oral ulcerations, and skin rashes on the hands and feet. The majority of HFMD cases resolve without consequence; however, a subset progresses to severe neurological and cardiopulmonary complications, which can be fatal. In the past two decades, EV-associated HFMD has received significant attention. In this review, we organize published papers and provide updates on epidemiology, pathogenesis, surveillance, and vaccine developments for EV-associated HFMD. The impact of EV-associated HFMD is increasing globally. Developing efficacious vaccines has become a priority for preventing EV infections without adequate treatment. Simultaneously, emerging EV infections (including EV-D68, EV-A71, Coxsackieviruses, and echoviruses) are increasing, highlighting the need to create a vigilant surveillance system for EV infections worldwide.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever. 评估克里米亚-刚果出血热患者的 YKL-40 水平与临床严重程度之间的关系。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.1080/20477724.2024.2392225

Murat Aydin, Nurten Nur Aydin, Esra Laloğlu

{"title":"Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever.","authors":"Murat Aydin, Nurten Nur Aydin, Esra Laloğlu","doi":"10.1080/20477724.2024.2392225","DOIUrl":"10.1080/20477724.2024.2392225","url":null,"abstract":"Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne viral disease. YKL-40 (also known as chitinase-3-like-1 protein) is an acute phase protein released by various immune cells. The purpose of this study was to investigate the relationship between YKL-40 level and the clinical course and prognosis of CCHF. The study included 78 patients who were admitted to our hospital between April 15 and 30 August 2022 and had a positive polymerase chain reaction test result for CCHF. The patients were divided into two groups, severe and non-severe. In addition, a control group consisting of 22 healthy people was established. Mean serum YKL-40 levels were significantly higher in patients than controls (106.8 ng/mL ± 91.2 and 47.1 ng/mL ± 35.3, respectively; p < 0.001). However, mean YKL-40 levels were also significantly higher in patients with severe CCHF compared to non-severe cases (173.3 ± 112.3 and 67.5 ± 41.7, respectively; p < 0.001). A comparison of the 10 exitus patients and the 68 survivors revealed significantly higher YKL-40 levels in the exitus group (mean: 214.0 ± 139.0 and 92.8 ± 73.6, respectively; p = 0.001). A receiver operating characteristic analysis for YKL-40 levels to distinguish between severe and non-severe patients found an area under the curve of 0.925. YKL-40 levels were measured with a sensitivity of 97% and a specificity of 84% with a cutoff value of 90.7 ng/mL. YKL-40 levels measured at the time of hospital presentation in patients with CCHF can be used as a biomarker for clinical course and prognosis.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis. 1994 年至 2023 年全球和地区尼帕病毒死亡率统计：全面系统回顾和荟萃分析。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI: 10.1080/20477724.2024.2380131

Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya

{"title":"Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis.","authors":"Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya","doi":"10.1080/20477724.2024.2380131","DOIUrl":"10.1080/20477724.2024.2380131","url":null,"abstract":"The mortality rate of Nipah virus (NiV) can vary in different regions, and its pattern across timelines has yet to be assessed. The primary objective is to perform a comparative analysis of mortality rates across different timelines and countries. Articles reporting NiV mortality from inception to November 2023 were analyzed in PubMed, Ovid Embase, Scopus, and Web of Science databases. A meta-analysis utilizing random-effects models determined the mortality rate secondary to NiV complications. The initial search strategy yielded 1213 records, of which 36 articles met the inclusion criteria, comprising 2736 NiV patients. The Global mortality rate of the Nipah virus in the 2014-2023 decade was 80.1% (CI: 68.7-88.1%), indicating a significant 24% increase compared to the preceding decade (2004-2013) with a mortality rate of 54.1% (CI: 35.5-71.6%). Among the countries analyzed for overall mortality from 1994-2023, India experienced the highest mortality rate at 82.7% (CI: 74.6-88.6%), followed by Bangladesh at 62.1% (CI: 45.6-76.2%), Philippines at 52.9% (CI: 30-74.5%), Malaysia at 28.9% (CI: 21.4-37.9%), and Singapore at 21% (CI: 8-45%). Subgroup analysis revealed that India consistently had the highest mortality rate for the past two decades (91.7% and 89.3%). The primary complication leading to mortality was encephalitis, accounting for 95% of cases. This systematic review and meta-analysis revealed a noteworthy surge in NiV mortality rates, particularly in the current decade (2014-2023). The escalation, with India reporting a concerning level of mortality of 89.3-91.7% in the past decades, signifies a pressing public health challenge.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JN.1 and the ongoing battle: unpacking the characteristics of a new dominant COVID-19 variant. JN.1 和正在进行的战斗：解读 COVID-19 新变种的特征。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI: 10.1080/20477724.2024.2369378

Reza Eshraghi, Ashkan Bahrami, Motahare Karimi Houyeh, Maryam Nasr Azadani

引用次数: 0