Pathogens and Global Health最新文献_第2页

Capacity building for infectious disease control in Sub-Saharan Africa. 撒哈拉以南非洲传染病控制能力建设。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2023-10-18 DOI: 10.1080/20477724.2023.2272363

William C Lieber, Faraan O Rahim, Henry S Q Lartey, Devesh Shah, Blandina T Mmbaga, Nathan M Thielman, Julian T Hertz

引用次数: 0

Immunization of laboratory animal workers: occupational health and safety aspects. 实验动物工作人员的免疫接种：职业健康与安全问题。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2024-03-20 DOI: 10.1080/20477724.2024.2329376

Laxit K Bhatt, Jitendra H Patel, Chitrang R Shah, Sudhir R Patel, Shital D Patel, Vipul A Patel, Rajesh Sundar, Mukul R Jain

{"title":"Immunization of laboratory animal workers: occupational health and safety aspects.","authors":"Laxit K Bhatt, Jitendra H Patel, Chitrang R Shah, Sudhir R Patel, Shital D Patel, Vipul A Patel, Rajesh Sundar, Mukul R Jain","doi":"10.1080/20477724.2024.2329376","DOIUrl":"10.1080/20477724.2024.2329376","url":null,"abstract":"Occupational immunization is an integral part of institutional occupational safety and health (OSH) programs. Laboratory animal workers (LAWs) are personnel working with various small and large vertebrate animals. LAWs are at the risk of contracting a myriad of zoonotic infections as they are occupationally exposed to animals and their biological products. Immunizing employees against such zoonotic pathogens is the best way to prevent disease transmission. This review provides information on various zoonotic diseases, vaccines available to protect against such infections, and vaccination schedules. Certain sections of institutional occupational immunization programs such as risk evaluation, immunizing special categories of personnel and exemption from immunization among others are also described. Additionally, the authors have discussed various probable modes of impact through which occupational immunization of laboratory animal workers fulfills different United Nations Sustainable Development Goals.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential climate change effects on the distribution of urban and sylvatic dengue and yellow fever vectors. 气候变化对城市登革热和黄热病病媒分布的潜在影响。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2024-07-07 DOI: 10.1080/20477724.2024.2369377

Alisa Aliaga-Samanez, David Romero, Kris Murray, Marina Segura, Raimundo Real, Jesús Olivero

{"title":"Potential climate change effects on the distribution of urban and sylvatic dengue and yellow fever vectors.","authors":"Alisa Aliaga-Samanez, David Romero, Kris Murray, Marina Segura, Raimundo Real, Jesús Olivero","doi":"10.1080/20477724.2024.2369377","DOIUrl":"10.1080/20477724.2024.2369377","url":null,"abstract":"Climate change may increase the risk of dengue and yellow fever transmission by urban and sylvatic mosquito vectors. Previous research primarily focused on Aedes aegypti and Aedes albopictus. However, dengue and yellow fever have a complex transmission cycle involving sylvatic vectors. Our aim was to analyze how the distribution of areas favorable to both urban and sylvatic vectors could be modified as a consequence of climate change. We projected, to future scenarios, baseline distribution models already published for these vectors based on the favorability function, and mapped the areas where mosquitoes' favorability could increase, decrease or remain stable in the near (2041-2060) and distant (2061-2080) future. Favorable areas for the presence of dengue and yellow fever vectors show little differences in the future compared to the baseline models, with changes being perceptible only at regional scales. The model projections predict dengue vectors expanding in West and Central Africa and in South-East Asia, reaching Borneo. Yellow fever vectors could spread in West and Central Africa and in the Amazon. In some locations of Europe, the models suggest a reestablishment of Ae. aegypti, while Ae. albopictus will continue to find new favorable areas. The results underline the need to focus more on vectors Ae. vittatus, Ae. luteocephalus and Ae. africanus in West and Central sub-Saharan Africa, especially Cameroon, Central Africa Republic, and northern Democratic Republic of Congo; and underscore the importance of enhancing entomological monitoring in areas where populations of often overlooked vectors may thrive as a result of climate changes.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tegumentary leishmaniasis in Brazil: priority municipalities and spatiotemporal relative risks from 2001 to 2020. 巴西的利什曼病：2001 年至 2020 年的重点城市和时空相对风险。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI: 10.1080/20477724.2024.2367442

Saulo Nascimento de Melo, David Soeiro Barbosa, Daniel Cardoso Portela Câmara, Taynãna César Simões, Lia Puppim Buzanovsky, Anna Gabryela Sousa Duarte, Ana Nilce Silveira Maia-Elkhoury, Diogo Tavares Cardoso, Lucas Edel Donato, Guilherme Loureiro Werneck, Fábio Raphael Pascoti Bruhn, Vinícius Silva Belo

{"title":"Tegumentary leishmaniasis in Brazil: priority municipalities and spatiotemporal relative risks from 2001 to 2020.","authors":"Saulo Nascimento de Melo, David Soeiro Barbosa, Daniel Cardoso Portela Câmara, Taynãna César Simões, Lia Puppim Buzanovsky, Anna Gabryela Sousa Duarte, Ana Nilce Silveira Maia-Elkhoury, Diogo Tavares Cardoso, Lucas Edel Donato, Guilherme Loureiro Werneck, Fábio Raphael Pascoti Bruhn, Vinícius Silva Belo","doi":"10.1080/20477724.2024.2367442","DOIUrl":"10.1080/20477724.2024.2367442","url":null,"abstract":"Understanding the distribution of tegumentary leishmaniasis (TL) in different periods enables the adequate conduction of actions at the public health level. The present study analyzes the spatiotemporal evolution of TL incidence rates in the municipalities of Brazil and identifies priority areas from 2001 to 2020. Notifications of new cases were analyzed employing space-time scan statistics and Local Indicators of Spatial Association. As TL incidence rates presented a downward trend in most Brazilian municipalities, spatiotemporal clusters of high relative risks (RR) were more frequent in the first decade of the series. There was a concentration of those clusters in the North and Northeast regions, mainly in the Legal Amazon area. More recent high-RR areas were identified in municipalities of different regions. The number of priority municipalities showed a stable trend in Brazil. There was a great concentration of such municipalities in the states of Acre, Mato Grosso, Rondônia, Pará, and Amapá, as well as large areas in Roraima, Amazonas, Maranhão, and Tocantins, and smaller areas in the states of Goiás, Ceará, Bahia, Minas Gerais, São Paulo, and Paraná. The present study contributes to the understanding of the historical evolution of TL in Brazil and subsidizes actions to combat the disease.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell-derived exosomes as a potential therapy for schistosomal hepatic fibrosis in experimental animals. 干细胞衍生外泌体作为血吸虫肝纤维化实验动物的一种潜在疗法。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2023-07-30 DOI: 10.1080/20477724.2023.2240085

Asmaa R Ellakany, Hanan El Baz, Zeinab S Shoheib, Mohamed Elzallat, Dalia S Ashour, Nabila A Yassen

{"title":"Stem cell-derived exosomes as a potential therapy for schistosomal hepatic fibrosis in experimental animals.","authors":"Asmaa R Ellakany, Hanan El Baz, Zeinab S Shoheib, Mohamed Elzallat, Dalia S Ashour, Nabila A Yassen","doi":"10.1080/20477724.2023.2240085","DOIUrl":"10.1080/20477724.2023.2240085","url":null,"abstract":"Schistosomiasis is a neglected tropical disease. Egg-induced granuloma formation and tissue fibrosis are the main causes of the high morbidity and mortality of schistosomiasis. Mesenchymal stem cells (MSCs)-derived exosomes play an important role with a superior safety profile than MSCs in the treatment of liver fibrosis. Therefore, the aim of this study was to investigate the potential therapeutic effect of MSCs-derived exosomes on schistosomal hepatic fibrosis. Exosomes were isolated from bone marrow MSCs and characterized. A total of 85 mice were divided into four groups: group I (control group), group II (PZQ group) infected and treated with PZQ, group III (EXO group) infected and treated with MSCs-derived exosomes and group IV (PZQ+EXO group) infected and treated with both PZQ and MSCs-derived exosomes. Assessment of treatment efficacy was evaluated by histopathological and immunohistochemical examination of liver sections by proliferating cell nuclear antigen (PCNA) and nuclear factor-κB (NF-κB). The results showed significant reduction of the number and diameter of hepatic granulomas, hepatic fibrosis, upregulation of PCNA expression and reduction of NF-κB expression in EXO and PZQ+EXO groups as compared to other groups at all durations post infection. Additionally, more improvement was observed in PZQ+EXO group. In conclusion, MSCs-derived exosomes are a promising agent for the treatment of schistosomal hepatic fibrosis, and their combination with PZQ shows a synergistic action including antifibrotic and anti-inflammatory effects. However, further studies are required to establish their functional components and their mechanisms of action.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9888746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct inflammatory markers in primary and secondary dengue infection: can cytokines CXCL5, CXCL9, and CCL17 act as surrogate markers? 原发性和继发性登革热感染中的不同炎症标记物：细胞因子 CXCL5、CXCL9 和 CCL17 能否作为替代标记物？

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2024-06-17 DOI: 10.1080/20477724.2024.2365581

Zeeshan Mustafa, Haris Manzoor Khan, Syed Ghazanfar Ali, Hiba Sami, Ahmad Almatroudi, Masood Alam Khan, Arif Khan, Wafa Abdullah I Al-Megrin, Khaled S Allemailem, Islam Ahmad, Asmaa El-Kady, Mohammed Suliman Al-Muzaini, Mohammad Azam Khan, Mohd Azam

{"title":"Distinct inflammatory markers in primary and secondary dengue infection: can cytokines CXCL5, CXCL9, and CCL17 act as surrogate markers?","authors":"Zeeshan Mustafa, Haris Manzoor Khan, Syed Ghazanfar Ali, Hiba Sami, Ahmad Almatroudi, Masood Alam Khan, Arif Khan, Wafa Abdullah I Al-Megrin, Khaled S Allemailem, Islam Ahmad, Asmaa El-Kady, Mohammed Suliman Al-Muzaini, Mohammad Azam Khan, Mohd Azam","doi":"10.1080/20477724.2024.2365581","DOIUrl":"10.1080/20477724.2024.2365581","url":null,"abstract":"Dengue fever poses a significant global health threat, with symptoms including dengue hemorrhagic fever and dengue shock syndrome. Each year, India experiences fatal dengue outbreaks with severe manifestations. The primary cause of severe inflammatory responses in dengue is a cytokine storm. Individuals with a secondary dengue infection of a different serotype face an increased risk of complications due to antibody-dependent enhancement. Therefore, it is crucial to identify potential risk factors and biomarkers for effective disease management. In the current study, we assessed the prevalence of dengue infection in and around Aligarh, India, and explored the role of cytokines, including CXCL5, CXCL9, and CCL17, in primary and secondary dengue infections, correlating them with various clinical indices. Among 1,500 suspected cases, 367 tested positive for dengue using Real-Time PCR and ELISA. In secondary dengue infections, the serum levels of CXCL5, CXCL9, and CCL17 were significantly higher than in primary infections (P < 0.05). Dengue virus (DENV)-2 showed the highest concentrations of CXCL5 and CCL17, whereas DENV-1 showed the highest concentrations of CXCL9. Early detection of these cytokines could serve as potential biomarkers for diagnosing severe dengue, and downregulation of these cytokines may prove beneficial for the treatment of severe dengue infections.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141331546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How climate change influences pathogen transmission. 气候变化如何影响病原体传播。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2023-11-18 DOI: 10.1080/20477724.2023.2285185

Ahmad Z Al Meslamani

引用次数: 0

Land-cover, land-use and human hantavirus infection risk: a systematic review. 土地覆盖、土地利用与人类汉坦病毒感染风险:系统综述。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-07-01 Epub Date: 2023-10-24 DOI: 10.1080/20477724.2023.2272097

Giovenale Moirano, Annarita Botta, Mingyou Yang, Martina Mangeruga, Kris Murray, Paolo Vineis

{"title":"Land-cover, land-use and human hantavirus infection risk: a systematic review.","authors":"Giovenale Moirano, Annarita Botta, Mingyou Yang, Martina Mangeruga, Kris Murray, Paolo Vineis","doi":"10.1080/20477724.2023.2272097","DOIUrl":"10.1080/20477724.2023.2272097","url":null,"abstract":"Previous studies suggest that the risk of human infection by hantavirus, a family of rodent-borne viruses, might be affected by different environmental determinants such as land cover, land use and land use change. This study examined the association between land-cover, land-use, land use change, and human hantavirus infection risk. PubMed and Scopus databases were interrogated using terms relative to land use (change) and human hantavirus disease. Screening and selection of the articles were completed by three independent reviewers. Classes of land use assessed by the different studies were categorized into three macro-categories of exposure ('Agriculture', 'Forest Cover', 'Urban Areas') to qualitatively synthesize the direction of the association between exposure variables and hantavirus infection risk in humans. A total of 25 articles were included, with 14 studies (56%) conducted in China, 4 studies (16%) conducted in South America and 7 studies (28%) conducted in Europe. Most of the studies (88%) evaluated land cover or land use, while 3 studies (12%) evaluated land use change, all in relation to hantavirus infection risk. We observed that land cover and land-use categories could affect hantavirus infection incidence. Overall, agricultural land use was positively associated with increased human hantavirus infection risk, particularly in China and Brazil. In Europe, a positive association between forest cover and hantavirus infection incidence was observed. Studies that assessed the relationship between built-up areas and hantavirus infection risk were more variable, with studies reporting positive, negative or no associations.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary schistosomiasis and anemia among school-aged children from southwestern Nigeria. 尼日利亚西南部学龄儿童的尿血吸虫病和贫血症。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI: 10.1080/20477724.2024.2322800

Babatunde Adewale, Margaret A Mafe, Hammed O Mogaji, Joshua B Balogun, Medinat A Sulyman, Morakinyo B Ajayi, David O Akande, Emmanuel O Balogun

{"title":"Urinary schistosomiasis and anemia among school-aged children from southwestern Nigeria.","authors":"Babatunde Adewale, Margaret A Mafe, Hammed O Mogaji, Joshua B Balogun, Medinat A Sulyman, Morakinyo B Ajayi, David O Akande, Emmanuel O Balogun","doi":"10.1080/20477724.2024.2322800","DOIUrl":"10.1080/20477724.2024.2322800","url":null,"abstract":"Schistosomiasis and anemia, are one of the leading global public health problem among children between age 5 and 14 years in marginalized settings. In this study, we provide prevalence and intensity data for both conditions in three southwestern states of Nigeria, where such are lacking. Epidemiological assessment involving parasitological analysis of urine and blood samples was conducted among 1783 consenting school-aged children in Ondo, Osun, Ekiti States of Nigeria. Participants' age and sex data were obtained using field forms, and statistical analysis was performed in R software with a significance level of 95%. An overall prevalence of 26.8% and 29.5% was recorded for urinary schistosomiasis and anemia, respectively. Prevalence varied by location with (40.3% and 29.8%) in Ondo (34.4% and 37.5%) in Osun and (13.4% and 20.9%) in Ekiti for urinary schistosomiasis and anemia, respectively (p=0.00). Schistosoma infections were found among males (28.7%, p=0.05) and children between the age 9-11 years (30.0%, p=0.01). About 36% of children with anemia was also infected with schistosomiasis. Children who were positive for schistosomiasis (OR:1.51; 95% CI: 1.19, 1.93; p=0.001) and between the age category 15-16 years, (OR:1.86; 95% CI: 1.12, 3.09; p<0.05) were twice likely to become anemic. Our findings have shown that children infected with schistosomiasis are twice likely to become anemic than those without infection. It is important to complement ongoing MDA programmes targeted at schistosomiasis with nutrition intervention programs for example micronutrient supplementation for better impact and cost-effectiveness.","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate change and the spread of Aedes mosquito-borne viruses in Europe. 气候变化与伊蚊病毒在欧洲的传播。

IF 4.9 4区医学

Pathogens and Global Health Pub Date : 2024-06-01 Epub Date: 2024-02-29 DOI: 10.1080/20477724.2024.2323842

Giovanni Rezza

引用次数: 0