Klebsiella pneumoniae: a connecting link in the One Health concept.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Kanika Chawla, Pascal Piveteau, Shilpi Sharma
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引用次数: 0

Abstract

Klebsiella pneumoniae is the major cause of hospital-acquired infections worldwide. Besides hospitals, it is widely prevalent in diverse environmental settings, emphasizing the need to study it through the One Health approach. Dissemination of multidrug resistant, and/or hypervirulent, strains in the environment exacerbates the problem. However, only a few studies have examined its prevalence in the environment, leaving gaps in our understanding of its ecology across diverse habitats. A deeper insight into the pathogen's ecology is necessary to understand its dissemination routes. In this review, we have first discussed the taxonomy of the genus Klebsiella and widespread prevalence of the Klebsiella pneumoniae species complex. Key factors, including mechanisms driving multidrug resistance, contributing to its ubiquity and competitiveness have been discussed. Additionally, ecological roles played by K. pneumoniae have been outlined. Finally, the studies comparing clinical and environmental isolates of K. pneumoniae have been reviewed, and a road map for future work in the area have been presented.

肺炎克雷伯菌:“同一个健康”概念中的一个连接环节。
肺炎克雷伯菌是全世界医院获得性感染的主要原因。除医院外,它在各种环境环境中广泛流行,强调需要通过“同一个健康”方法对其进行研究。多药耐药和/或高毒菌株在环境中的传播加剧了这一问题。然而,只有少数研究调查了其在环境中的普遍程度,这使得我们对其在不同栖息地的生态的理解存在空白。更深入地了解病原体的生态对了解其传播途径是必要的。在这篇综述中,我们首先讨论了克雷伯菌属的分类和广泛流行的克雷伯菌肺炎种复合体。主要因素,包括驱动多药耐药的机制,有助于其普遍性和竞争力进行了讨论。此外,还概述了肺炎克雷伯菌的生态作用。最后,对临床分离株和环境分离株肺炎克雷伯菌的比较研究进行了综述,并提出了该领域未来工作的路线图。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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