{"title":"<i>Klebsiella pneumoniae</i>: a connecting link in the One Health concept.","authors":"Kanika Chawla, Pascal Piveteau, Shilpi Sharma","doi":"10.1080/20477724.2025.2506042","DOIUrl":null,"url":null,"abstract":"<p><p><i>Klebsiella pneumoniae</i> is the major cause of hospital-acquired infections worldwide. Besides hospitals, it is widely prevalent in diverse environmental settings, emphasizing the need to study it through the One Health approach. Dissemination of multidrug resistant, and/or hypervirulent, strains in the environment exacerbates the problem. However, only a few studies have examined its prevalence in the environment, leaving gaps in our understanding of its ecology across diverse habitats. A deeper insight into the pathogen's ecology is necessary to understand its dissemination routes. In this review, we have first discussed the taxonomy of the genus <i>Klebsiella</i> and widespread prevalence of the <i>Klebsiella pneumoniae</i> species complex. Key factors, including mechanisms driving multidrug resistance, contributing to its ubiquity and competitiveness have been discussed. Additionally, ecological roles played by <i>K. pneumoniae</i> have been outlined. Finally, the studies comparing clinical and environmental isolates of <i>K. pneumoniae</i> have been reviewed, and a road map for future work in the area have been presented.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"1-14"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathogens and Global Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20477724.2025.2506042","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Klebsiella pneumoniae is the major cause of hospital-acquired infections worldwide. Besides hospitals, it is widely prevalent in diverse environmental settings, emphasizing the need to study it through the One Health approach. Dissemination of multidrug resistant, and/or hypervirulent, strains in the environment exacerbates the problem. However, only a few studies have examined its prevalence in the environment, leaving gaps in our understanding of its ecology across diverse habitats. A deeper insight into the pathogen's ecology is necessary to understand its dissemination routes. In this review, we have first discussed the taxonomy of the genus Klebsiella and widespread prevalence of the Klebsiella pneumoniae species complex. Key factors, including mechanisms driving multidrug resistance, contributing to its ubiquity and competitiveness have been discussed. Additionally, ecological roles played by K. pneumoniae have been outlined. Finally, the studies comparing clinical and environmental isolates of K. pneumoniae have been reviewed, and a road map for future work in the area have been presented.
期刊介绍:
Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.