Impact of immunosuppression on Listeria monocytogenes infection in Spain.

IF 4.9 4区医学 Q1 PARASITOLOGY

Pathogens and Global Health Pub Date : 2025-02-27 DOI:10.1080/20477724.2025.2472300

Elena Vázquez, Oscar de Gregorio, Carmen Álvarez, Vicente Soriano, Octavio Corral, Alfonso Ortega-de la Puente, Marina de la Cruz-Echeandía, Xiomara Patricia Blanco-Valencia, Ana Royuela, Mario Martín-Portugués, Jorge Esteban-Sampedro, Víctor Moreno-Torres

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引用次数: 0

Abstract

Introduction: Immunosuppression (IS) determines a higher risk of disease severity from Listeria monocytogenes (LM) infection.

Methods: We examined the epidemiology of IS in all patients hospitalized with LM in Spain from 2000 to 2021 in the National Registry of Hospital Discharges. IS was defined by liver disease (LD), diabetes mellitus (DM), chronic kidney disease (CKD), solid organ transplantation (SOT), bone marrow transplantation (BMT), primary immunodeficiencies (ID), systemic autoimmune diseases (SAD), solid organ neoplasms (SON), and hematological neoplasms (HN).

Results: Among 8,152 admissions with LM, 48% were IS. There was an increase from 39.5% to 60% during the study period, mainly driven by rises in DM (from 12.6% to 26.2%), SON (from 9.9% to 17.5%), CKD (from 4.4% to 16.3%), HN (from 6.6% to 13.4%), and LD (from 4.9% to 6.6%) (p < 0.001 for all trends). IS fatality rate was higher than in non-IS (22.4% vs 11.3%; OR = 2.09). The proportion of LM patients with IS among LM in-hospital deaths increased from 57.1% in 2000 to 67.95% in 2021 (p < 0.001). Fatality risk differed according to baseline IS condition: LD (OR = 2.42), CKD (OR = 1.49), SON (OR 3.01) and HN (OR 1.45).

Conclusions: The prevalence of IS among patients hospitalized with LM in Spain has risen over the past two decades, with a growing impact on fatality rates. These findings should prompt further efforts to prevent and manage properly LM infection.

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来源期刊

Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.