实体器官移植受者中的隐孢子虫感染:系统回顾和荟萃分析。

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2024-06-01 Epub Date: 2023-12-06 DOI:10.1080/20477724.2023.2290379
Shahira Abdelaziz Ali Ahmed, Annalisa Quattrocchi, Panagiotis Karanis
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引用次数: 0

摘要

(1) 背景:器官移植受者(OTR)是容易受到寄生虫感染的群体。本系统综述和荟萃分析旨在评估隐孢子虫在器官移植受者中的总体流行率,并揭示器官移植的这一潜在严重并发症。(2)方法:我们在四个数据库(Academia、PubMed、Scopus 和 Science Direct)中系统地检索了有关 OTR 中隐孢子虫感染的研究。研究采用随机效应模型计算出汇总的感染率估计值及 95% 的置信区间 (CI)。还进行了分组和元回归分析。此外,还对纳入的研究进行了质量评估。(3) 结果:在检索到的 876 篇文章中,共纳入 21 篇,涉及 2,642 例 OTR。20 项研究为横断面研究,其中 7 项研究报告了对比组的数据,1 项研究为回顾性队列研究。OTR中隐孢子虫的总体流行率为15%(95% CI:7.4-24.6)。亚组分析显示,隐孢子虫感染率在成人、无症状者、发展中国家以及仅使用非分子方法的研究中较高。不过,也有报道称存在很大的异质性。在儿童(5.8;95% CI:2.8-9.6)、发达国家(5.8;95% CI:3.0-9.4)以及同时使用分子和非分子诊断方法的研究(11.4;95% CI:6.4-17.4)等报告隐孢子虫感染率较低的亚组中,观察到了低到中等程度的异质性。列出的大多数研究都报告了中低质量得分。(4) 结论:隐孢子虫感染是口腔溃疡治疗中的一个重要并发症,但报告的发病率较低。减少负担的预防策略应包括对 OTR 进行隐孢子虫常规筛查,尤其是移植后腹泻患者。要确定 OTR 中隐孢子虫负担的程度,还需要进行更多设计良好的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cryptosporidium sp. infection in solid organ transplant recipients: A systematic review and meta-analysis.

(1) Background: Organ transplant recipients (OTRs) are vulnerable groups at risk of parasitic infections. This systematic review and meta-analysis aimed to evaluate the overall prevalence of Cryptosporidium sp. in OTRs and shed light on this potentially serious complication of organ transplantation. (2) Methods: We systematically searched studies on Cryptosporidium sp. infections in OTRs in four databases (Academia, PubMed, Scopus, and Science Direct). Random effects models were used to calculate pooled prevalence estimates with 95% confidence intervals (CIs). Sub-group and meta-regression analyses were conducted. A quality assessment of the included studies was also performed. (3) Results: Among 876 articles retrieved, 21 were included, accounting for 2,642 OTRs. Twenty studies were cross-sectional in design, of which seven reported data on a comparison group, and one was a retrospective cohort. The pooled prevalence of Cryptosporidium sp. in OTRs was 15% (95% CI: 7.4-24.6). Subgroup analysis revealed that the prevalence of Cryptosporidium sp. infection was higher in adults, symptomatics and developing countries and in studies using only non-molecular methods. However, substantial heterogeneity was reported. Low to moderate heterogeneity was observed in subgroups reporting lower prevalence Cryptosporidium sp. including children (5.8; 95% CI: 2.8-9.6), studies conducted in developed countries (5.8; 95% CI: 3.0-9.4) and studies using both molecular and non-molecular diagnostics (11.4; 95% CI: 6.4-17.4). The majority of the listed research reported low-medium quality scores. (4) Conclusion: Cryptosporidium sp. infection is a significant complication in OTRs with underreported prevalence. Preventive strategies to reduce the burden should include Cryptosporidium sp. routine screening for OTRs, particularly post-transplantation in patients with diarrhea. Additional well-designed research studies are required to determine the extent of the Cryptosporidium sp. burden in OTRs.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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