Pediatric Blood & Cancer最新文献_第2页

Sodium Thiosulfate for Ototoxicity Prevention: A National Review of UK Practice.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1002/pbc.31536

Jonathan Abrams, Rebecca Hill, Barry Pizer, Jessica Bate

引用次数: 0

Association of Unmet Social Needs With Disease-Related Outcomes in Pediatric Patients With Sickle Cell Disease. 儿童镰状细胞病患者未满足的社会需求与疾病相关结局的关系

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1002/pbc.31478

Molly Sonenklar, Sarah Marks, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler

{"title":"Association of Unmet Social Needs With Disease-Related Outcomes in Pediatric Patients With Sickle Cell Disease.","authors":"Molly Sonenklar, Sarah Marks, Cerelia Donald, Cecelia Valrie, Wally Smith, India Sisler","doi":"10.1002/pbc.31478","DOIUrl":"10.1002/pbc.31478","url":null,"abstract":"Background: Social determinants of health (SDoH) are socioeconomic factors that influence health and well-being, though when unmet can greatly contribute to health disparities. Individuals with sickle cell disease (SCD) are at increased risk of mortality, disability, and healthcare utilization. However, there are limited data linking specific social needs with disease outcomes in this population. Therefore, we sought to identify the unmet needs in one institution and their association with healthcare utilization.Methods: Children with SCD and their guardians answered demographic and SDoH questionnaires during routine Sickle Cell Clinic appointments. We defined an unmet social need as any positive answer to the SDoH questionnaire. Disease outcome variables were electronic health record (EHR)-documented emergency department (ED) visits, hospitalizations, clinic appointment attendance, and guardian-reported acute SCD events in the previous year.Results: A total of 114 parent-guardian dyads participated, with 103 having complete data to analyze. In all, 52% of subjects reported at least one unmet social need with food insecurity (36%), trouble paying utility bills (28%), and unemployment (16%) being the most prevalent. Subjects with at least one unmet need had two times the rate of ED visits and/or hospitalizations and were 1.15 times more likely to have an SCD event in the past year. However, only the association with ED visits was statistically significant (p = 0.03).Conclusion: Over half of subjects reported at least one unmet need; the most common being reliable access to food, which has the potential to impact health outcomes of sickle cell patients. Furthermore, unmet social needs are linked to healthcare utilization and SCD-related complications, supporting routine screening for SDoH in this population.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31478"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The St. Jude Global Academy: A Multifaceted Education Program to Expand Pediatric Oncology Workforce Capacity. 圣犹达全球学院：一个多方面的教育计划，以扩大儿科肿瘤工作人员的能力。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2025-01-05 DOI: 10.1002/pbc.31499

Daniel C Moreira, Saman K Hashmi, Allyson Andujar, Fair Berg, Kristy Conger, Leeanna Fox Irwin, Margit Mikkelsen, Federico Antillón-Klussmann, Faiha Bazzeh, Monica Cypriano, Yi-Jin Gao, Oscar González-Ramella, Silvia Rivas, Luiz Fernando Lopes, Ricardo Mack, Fabiana Morosini, Dolly Noun, Ximena Garcia, Maysam R Homsi, Maria Puerto-Torres, Asya Agulnik, Justin N Baker, Miguela A Caniza, Michael J McNeil, Ibrahim Qaddoumi, Guillermo Chantada, Carlos Rodríguez-Galindo

{"title":"The St. Jude Global Academy: A Multifaceted Education Program to Expand Pediatric Oncology Workforce Capacity.","authors":"Daniel C Moreira, Saman K Hashmi, Allyson Andujar, Fair Berg, Kristy Conger, Leeanna Fox Irwin, Margit Mikkelsen, Federico Antillón-Klussmann, Faiha Bazzeh, Monica Cypriano, Yi-Jin Gao, Oscar González-Ramella, Silvia Rivas, Luiz Fernando Lopes, Ricardo Mack, Fabiana Morosini, Dolly Noun, Ximena Garcia, Maysam R Homsi, Maria Puerto-Torres, Asya Agulnik, Justin N Baker, Miguela A Caniza, Michael J McNeil, Ibrahim Qaddoumi, Guillermo Chantada, Carlos Rodríguez-Galindo","doi":"10.1002/pbc.31499","DOIUrl":"10.1002/pbc.31499","url":null,"abstract":"There is currently a global shortage of healthcare professionals equipped to handle the rising burden of childhood cancer. St. Jude Global is an initiative to improve survival rates of children with cancer worldwide while improving access to quality care. One of the overriding goals of St. Jude Global is focused on education: the training of the clinical workforce needed to expand quality care for all children with cancer. Herein, we describe the St. Jude Global Academy (SJGA) and its programs. The three main workstreams of the SJGA are: clinical training programs, courses, and distance learning. St. Jude collaborates with eight institutions in seven low- and middle-income countries to train pediatric subspecialists. Each year, approximately 20 new fellows start at these clinical training programs. To date, 92 specialists have been trained. The SJGA's courses create educational opportunities that provide a structured learning experience in key areas that are relevant to pediatric cancer care. To date, 1081 participants from 372 institutions in 84 countries have successfully completed these educational opportunities. Cure4Kids is the SJGA's distance learning platform. Over 9000 healthcare professionals in 177 countries use Cure4Kids. The platform receives 1400 visits and over 13,000 page views per day. The SJGA's multifaceted approach encompasses various disciplines and skills, providing healthcare professionals from around the world the skills to address the needs of children diagnosed with cancer in their respected institutions. These efforts are essential for building workforce capacity to improve outcomes.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31499"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Rurality and Race/Ethnicity and Pediatric Cancer Early Mortality: A Population-Based Cohort Study Using SEER Data from 2000 to 2021.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1002/pbc.31520

Kiersten Preuss, Emma Hymel, Melissa Acquazzino, Shinobu Watanabe-Galloway

{"title":"Association Between Rurality and Race/Ethnicity and Pediatric Cancer Early Mortality: A Population-Based Cohort Study Using SEER Data from 2000 to 2021.","authors":"Kiersten Preuss, Emma Hymel, Melissa Acquazzino, Shinobu Watanabe-Galloway","doi":"10.1002/pbc.31520","DOIUrl":"10.1002/pbc.31520","url":null,"abstract":"Background: Pediatric cancer mortality rates have steadily declined since 2009, but over a thousand deaths still occur annually. While existing research highlights the effects of race/ethnicity and rurality on overall survival, few studies have specifically analyzed these factors in relation to early mortality, defined as death within 12 months of diagnosis.Procedure: This study utilized SEER Research Plus Limited-Field Data (2000-2021) to examine the association between race/ethnicity, rurality, and early mortality in pediatric cancer patients. A cohort of 138,648 individuals was analyzed using Cox proportional hazards regression models to calculate hazard ratios and 95% confidence intervals (CIs).Results: The results demonstrated that both race/ethnicity and rurality were significantly associated with early mortality. Non-Hispanic Black patients were 70% (95% CI: 1.60-1.82) more likely to die within the first year of diagnosis compared to non-Hispanic Whites, and other racial/ethnic groups also saw significant associations. The adjusted hazard ratio for early mortality compared to urban counties greater than 1 million was significant (p < 0.05) for all degrees of rurality. Pediatric cancer patients in rural counties not adjacent to urban counties had the highest risk of early mortality, 27% (95% CI: 1.13-1.42), within 1 year of diagnosis. A subanalysis of adolescent patients also showed similar patterns.Conclusions: These findings emphasize the need to address disparities in early mortality for pediatric cancer patients, particularly among racial/ethnic minorities and those in rural communities.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 3","pages":"e31520"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of Utilizing a Brief Neurocognitive Battery in 3-Year-Old Patients During Treatment for Acute Lymphoblastic Leukemia. 3岁急性淋巴细胞白血病患者在治疗期间使用短暂神经认知电池的可行性。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1002/pbc.31469

Sameera Ramjan, Peter D Cole, Melanie Blair-Thies, Lewis B Silverman, Amy Fredrickson, Adrian Schembri, Jennifer J Greene Welch, Justine Kahn, Kara M Kelly, Thai-Hoa Tran, Bruno Michon, Lisa Gennarini, Stephen A Sands

引用次数: 0

Coagulation Dysfunction Caused by a De Novo Mutation of Gene SLC37A4. SLC37A4基因从头突变引起凝血功能障碍。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1002/pbc.31488

Mauro Guariento, Nicola Martinelli, Laura Pezzoli, Federica Bortolotti, Elisa Bonetti, Ada Zaccaron, Matteo Chinello, Virginia Vitale, Giulia Caddeo, Vincenza Pezzella, Maria Pia Esposto, Chiara Guardo, Simone Cesaro

引用次数: 0

Complex Karyotype in a Pediatric Patient with Double-Hit BCL6 High-Grade B-Cell Lymphoma. 双重打击BCL6高级别b细胞淋巴瘤患儿的复杂核型

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2025-01-05 DOI: 10.1002/pbc.31508

Mariana Quatrin, Silvina Romano, Laura Cabaleiro, Claudia Pasti, Belén Iarossi, Paula Pérez, Eugenia Margarita Altamirano, Virginia Schuttenberg, Alejandro Laudicina, Mauro García Montenegro, Irma Slavutsky

引用次数: 0

Partnership With Patient Advocacy Organizations Improves Research Recruitment. 与患者权益组织合作可提高研究人员的招募率。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-15 DOI: 10.1002/pbc.31474

Lori Wiener, Kimberly Buff, Kimberly Canter, Emily Pariseau, Michele A Scialla, Victoria Sardi Brown, Anne E Kazak

引用次数: 0

Return-to-School Experiences of Adolescents After Allogeneic Hematopoietic Cell Transplant: A Qualitative Interview Study of Transplant Recipients. 异基因造血细胞移植后青少年返校经历：对移植受者的定性访谈研究。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1002/pbc.31481

Olivia A Do, Timothy J D Ohlsen, Kelly J Shipman, Sheri A Ballard, Kari M Jenssen, K Scott Baker, Abby R Rosenberg, Krysta S Barton, Neel S Bhatt

{"title":"Return-to-School Experiences of Adolescents After Allogeneic Hematopoietic Cell Transplant: A Qualitative Interview Study of Transplant Recipients.","authors":"Olivia A Do, Timothy J D Ohlsen, Kelly J Shipman, Sheri A Ballard, Kari M Jenssen, K Scott Baker, Abby R Rosenberg, Krysta S Barton, Neel S Bhatt","doi":"10.1002/pbc.31481","DOIUrl":"10.1002/pbc.31481","url":null,"abstract":"Background: Returning to school after allogeneic hematopoietic cell transplant (HCT) can improve quality of life and promote positive adjustment. However, this process may be challenging, and there is a limited understanding of school-aged children and adolescents' perspectives on this process.Methods: We conducted semi-structured interviews over video with pediatric recipients of HCT (10-18 years of age at HCT; 1-7 years post HCT) who were treated at our institution and had returned to in-person school post HCT. We performed a thematic network analysis focused on exploring salient challenges regarding the return-to-school process post HCT and potential areas for improvement.Results: We interviewed 16 participants (mean age 13.8 years at HCT). Four themes emerged: (i) challenges of returning to school, (ii) keys for a successful return-to-school experience, (iii) overall perceptions of the process, and (iv) recommendations for improvement. HCT recipients described several social/emotional, physical, and academic challenges while returning to school and cited strong sources of support as critical to a successful transition. Recommendations for a better transition process included the following: (a) fostering peer support, (b) establishing social connections, (c) providing mental health support, (d) identifying a go-to point of contact for issues, and (e) maintaining academic support.Conclusions: Our findings highlight perspectives from school-aged recipients of HCT regarding gaps in support and areas for improvement to facilitate successful return to school after HCT. Additional assistance throughout the process may optimize academic and social reintegration and support recovery after HCT.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31481"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer Stage Geospatial Analysis to Optimize Educational Activities in Pediatric Oncology and Hematology: A Retrospective Cohort Study. 癌症分期地理空间分析优化儿童肿瘤学和血液学教育活动：一项回顾性队列研究。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1002/pbc.31494

Monika Barełkowska, Barbara Więckowska, Martyna Borowczyk, Katarzyna Derwich

{"title":"Cancer Stage Geospatial Analysis to Optimize Educational Activities in Pediatric Oncology and Hematology: A Retrospective Cohort Study.","authors":"Monika Barełkowska, Barbara Więckowska, Martyna Borowczyk, Katarzyna Derwich","doi":"10.1002/pbc.31494","DOIUrl":"10.1002/pbc.31494","url":null,"abstract":"Background: Enhancing therapy outcomes in pediatric oncology and hematology relies on robust epidemiological surveillance. This study aimed to estimate cancer stage-related survival in pediatric patients with lymphoma and solid tumors by assessing changes over time and identifying spatial clustering of patients diagnosed at advanced stages.Procedure: This retrospective observational cohort study included pediatric cancer patients treated in a single Greater Poland center, constituting 9% of Polish children from 2004 to 2017. The incidence, cancer stage, and patient coordinates were analyzed. The follow-up period ranged from 5 to 18 years. Survival differences across tumor stages were evaluated using Kaplan‒Meier curves, log-rank tests, and trend analysis. Geographical analysis was performed with Kulldorff's scan statistics and the Bernoulli model.Results: Among 1094 diagnosed patients, 511 with lymphoma and solid tumors were eligible. There was a decreasing trend in advanced-stage diagnoses (p = 0.0001), with a nearly twofold increase in low-stage diagnoses (OR = 1.98 [1.22; 3.24], p = 0.0061) from 2009-2011 to 2015-2017. Hazard ratios for neuroblastoma and sarcoma patients were more than fourfold greater, while survival differences were not significant for patients with nephroblastoma, germ cell tumors, or lymphoma.Conclusions: This study shows cancer stage-related survival dynamics. A substantial decrease in advanced-stage diagnoses over time emphasizes improved early detection. Geographical analysis pinpointed clusters with prevalent late-stage diagnoses, offering a practical tool for targeted educational interventions. The study underscores the pivotal impact of cancer stage on survival outcomes, emphasizing the need for ongoing surveillance and tailored interventions to further optimize pediatric oncology and hematology care.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31494"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0