Pediatric Blood & Cancer最新文献

{"title":"Three and Four Courses of Radiation for Children with Recurrent Diffuse Intrinsic Pontine Glioma.","authors":"Nisha Shariff, Anthony Lausch, Eric Bouffet, Derek S Tsang","doi":"10.1002/pbc.31695","DOIUrl":"https://doi.org/10.1002/pbc.31695","url":null,"abstract":"<p><strong>Purpose: </strong>Re-irradiation (RT2) for children with diffuse intrinsic pontine glioma (DIPG) is increasingly used upon recurrence; however, limited data are available for evaluating additional courses of radiotherapy (RT) for DIPG. The purpose of this case series was to report our institutional experience in treating patients with recurrent DIPG with three (RT3) or four (RT4) courses of RT.</p><p><strong>Material and methods: </strong>A retrospective study of all children with DIPG treated with RT3 or RT4 at a single institution was performed. Medical records were reviewed, and composite dosimetry across all delivered courses of RT was reconstructed. All patients received conventionally fractionated photon RT at 1.8-2 Gy per day, with RT3 or RT4 dose prescriptions ranging 18-21.6 Gy in 10-12 fractions to the brainstem.</p><p><strong>Results: </strong>Five patients were identified; four received three courses of RT while one received four to the brainstem. Median survival from the last course of radiation to death was 4 months; median survival from the first course of RT was 26 months. The median cumulative brainstem D0.03cc for all courses of radiation was 104 Gy (interquartile range: 102-112 Gy). The median time from RT2 to RT3 was 8 months, with partial neurologic recovery (80%) or stable symptoms (20%) after RT3. Radiological appearance of tumor or brainstem necrosis was reported in two patients after RT3 (40%).</p><p><strong>Conclusions: </strong>A third course of RT may be carefully considered as a treatment option for selected children with recurrent DIPG to provide palliation of neurologic symptoms.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31695"},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraventricular Neurocytoma in a Five-Month-Old Infant","authors":"Han Wang,&nbsp;Yuan Fang,&nbsp;Lian Chen","doi":"10.1002/pbc.31718","DOIUrl":"10.1002/pbc.31718","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Perceived Health-Related Information Adequacy in the Experiences of Parents of Children With Complex Vascular Anomalies","authors":"Karan K. Mirpuri,&nbsp;Bryan Sisk,&nbsp;Christine Bereitschaft,&nbsp;Anna M. Kerr","doi":"10.1002/pbc.31697","DOIUrl":"10.1002/pbc.31697","url":null,"abstract":"<div>\u0000 \u0000 <p>Parents of children with complex vascular anomalies (VAs) struggle to locate credible information. We explored whether their perceptions of the adequacy of VA-related information were associated with caregiver burden, anxiety, child health, and their ability to navigate the healthcare system and seek information. We also examined how their perceptions of clinician knowledge and communication affect their perceptions of information adequacy. A total of 86 parents completed our online survey. Perceived information adequacy was associated with lower anxiety, greater ability to navigate the healthcare system, greater clinician knowledge, and better clinician communication. These data identify important communication barriers that future research studies should address.</p>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory Fitness, Physical Performance and Metabolic Syndrome in Adult Survivors of Paediatric Haematopoietic Stem Cell Transplantation","authors":"Anne Nissen,&nbsp;Tina Gerbek,&nbsp;Kathrine Fogelstrøm,&nbsp;Peter Schmidt-Andersen,&nbsp;Kaspar Sørensen,&nbsp;Abigail Louise Mackey,&nbsp;Martin Kaj Fridh,&nbsp;Klaus Müller","doi":"10.1002/pbc.31684","DOIUrl":"10.1002/pbc.31684","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We examined cardiorespiratory fitness and physical performance in long-term survivors of paediatric haematopoietic stem cell transplantation (HSCT) and explored how these are associated with the presence of metabolic syndrome (MetS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Procedure</h3>\u0000 \u0000 <p>We included 90 survivors of paediatric HSCT (median age, 30.3 years; range, 19.6–53.0; median follow-up time, 20.2 years) and 32 healthy controls. Cardiorespiratory fitness was evaluated by cardiopulmonary exercise tests, and physical performance was assessed through sit-to-stand, handgrip strength, timed-up-and-go, walking pace and six-minute walk tests. We assessed for components of MetS (blood pressure, waist circumference, plasma lipids, and glucose). For comparison of physical capacity between survivors and controls and survivors with or without the presence of MetS, a multiple linear regression analysis corrected for age and sex was applied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Survivors demonstrated lower cardiorespiratory fitness compared with controls (mean ± SD VO₂ peak 29.3 ± 7.0 mL/kg/min vs. 44.3 ± 6.8 mL/kg/min, <i>p</i> &lt; 0.0001) and impairment in all physical performance outcomes, where the most prominent differences compared with controls were seen in the sit-to-stand test (33% reduction). Twenty-eight percent of survivors fulfilled the criteria for MetS. The presence of MetS associated with lower VO₂ peak (<i>p</i> = 0.03), poorer outcomes in the six-minute walk test (<i>p</i> = 0.02), walking pace (<i>p</i> = 0.03) and the timed-up-and-go test (<i>p</i> = 0.003).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Young adult survivors of paediatric HSCT are at risk of markedly reduced physical capacity compared with age- and sex-matched controls, and the high incidence of MetS observed among survivors was associated with this impairment. Overall, these data underline the importance of monitoring physical capacity in survivors of paediatric HSCT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31684","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Cohort Analysis of Children and Adolescents With Lymphoblastic Lymphoma in Latin America","authors":"Magdalena Schelotto,&nbsp;Claudia Garrido,&nbsp;Jaqueline Montoya,&nbsp;Bruno Cuturi,&nbsp;Ana Rosa Braz,&nbsp;Flavio Luisi,&nbsp;Mario Alberto Ornelas Sanchez,&nbsp;Wendy Gomez,&nbsp;Pascale Gassant,&nbsp;Kenia Miller,&nbsp;Armando Peña,&nbsp;Godwin Job,&nbsp;Hilmarie Muniz-Talavera,&nbsp;Meenakshi Devidas,&nbsp;Victor M. Santana,&nbsp;Sima Jeha,&nbsp;Paola Friedrich,&nbsp;Monika L. Metzger,&nbsp;Guillermo L. Chantada","doi":"10.1002/pbc.31674","DOIUrl":"10.1002/pbc.31674","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Information about pediatric lymphoblastic lymphoma (LLy) in low- and middle-income countries is scarce. Thus, here we describe the clinical characteristics, treatment, and outcome of a large cohort of children and adolescents with LLy in Latin America.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted of pediatric patients with LLy treated at 10 institutions (2007–2017) that are members of the St. Jude Global Alliance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 126 patients were included: 60 (47.6%) had T-cell LLy, 49 (38.9%) had precursor B-cell LLy, and 17 (13.5%) had LLy with an unknown immunophenotype. Ninety-seven (77%) presented with stage III/IV disease, and 42 (33.3%) had complications at diagnosis. In 30 (23.8%) cases, the pathology diagnosis was received more than 15 days after the biopsy, and in 23 (18.2%) cases, a pathology review at another institution was required. The 5-year event-free survival and overall survival were 73% and 78%, respectively. Abandonment-sensitive event-free survival and overall survival were 65% and 70%, respectively. Events included disease relapse/progression (<i>n</i> = 22), refractory disease (<i>n</i> = 1), treatment abandonment (<i>n</i> = 11), death during induction (<i>n</i> = 4), death during complete remission (<i>n</i> = 4), and second malignancy (<i>n</i> = 1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Diagnosis of pediatric LLy in Latin America was challenging; however, the proportions of T-cell and precursor B-cell immunophenotypes were balanced. Most patients presented with high-risk disease, and many had critical conditions, leading to a relatively high toxic death rate. Improvements in diagnosis, supportive measures, and follow-up are imperative to decrease treatment abandonment and improve the outcomes of pediatric patients with LLy in Latin America.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Duffy Null and Its Impact on Hydroxyurea Dosing in Children With Sickle Cell Disease","authors":"Jill S. Menell,&nbsp;S. Raelle Jackson,&nbsp;Alissa R. Kahn,&nbsp;William C. Woolbright,&nbsp;Leya Y. Schwartz,&nbsp;John Norko","doi":"10.1002/pbc.31693","DOIUrl":"10.1002/pbc.31693","url":null,"abstract":"<div>\u0000 \u0000 <p>Duffy null phenotype is common in people of African ancestry and is associated with lower baseline white blood cell (WBC) and neutrophil counts. We evaluated whether the presence of the Duffy null phenotype had any association with neutropenia in our patients with sickle cell disease on hydroxyurea (HU). We found a statistically significant difference (<i>p</i> = 0.006) in HU maximum tolerated dose (MTD) in patients with Duffy null phenotype compared with Duffy-positive individuals. Our study suggests that careful dose escalation is warranted in Duffy-null individuals.</p>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monosomy 10 Mosaicism as an Incidental Finding in Acute Lymphoblastic Leukemia","authors":"Dany Assaf Curi,&nbsp;Constance K. Stein,&nbsp;Robert Roger Lebel,&nbsp;Gloria A. Kennedy","doi":"10.1002/pbc.31681","DOIUrl":"10.1002/pbc.31681","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression Screening and Primary Care Engagement and Their Association With Socioeconomic Disadvantage Among Adolescents Aged 13–17 Years With Sickle Cell Disease","authors":"Anyssa Young,&nbsp;Joseph Stanek,&nbsp;Robert M. Cronin,&nbsp;Susan E. Creary","doi":"10.1002/pbc.31655","DOIUrl":"10.1002/pbc.31655","url":null,"abstract":"<p>It is unclear if adolescents with sickle cell disease (SCD) are screened for depression, since primary care provider (PCP) visits decline with age and socioeconomic disadvantage may impact receipt of care. This 1-year study identified 97% of adolescents with SCD at Nationwide Children's Hospital (NCH) had a PCP. Among those with an NCH PCP (<i>n</i> = 55), 40% saw their PCP and 33% were screened for depression. Socioeconomic disadvantage was not associated with receipt of depression screening (<i>p</i> = 0.55) or PCP care (<i>p</i> = 0.22). While adolescents with SCD often have PCPs, interventions to increase PCP engagement may improve depression identification in this high-risk population.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31655","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes Toward COVID-19 Vaccination Among Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers","authors":"Janna R. Shapiro,&nbsp;Gilla K. Shapiro,&nbsp;Sumit Gupta,&nbsp;Sarah Alexander,&nbsp;Michelle Science,&nbsp;Tania H. Watts,&nbsp;Shelly Bolotin","doi":"10.1002/pbc.31696","DOIUrl":"10.1002/pbc.31696","url":null,"abstract":"<p>The COVID-19 vaccine is indicated for children with acute lymphoblastic leukemia (ALL), yet patients and caregivers may have unique questions and concerns about vaccination. We surveyed children with ALL or their caregivers (<i>N</i> = 44) to understand factors contributing to the decision to vaccinate and identify cues to vaccination tailored to this population. For caregivers of unvaccinated ALL patients, lack of knowledge about the COVID-19 vaccine and concerns about vaccine safety and efficacy were the most reported barriers to vaccination. A recommendation from a hematologist/oncologist and vaccine safety and efficacy data in children with ALL were the most cited cues to vaccination.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31696","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benchmarks for Psychosocial Staffing in Pediatric Oncology: Implementing the Standards Together—Engaging Parents and Providers in Psychosocial Care (iSTEPPP) Study","authors":"Michele A. Scialla,&nbsp;Lori Wiener,&nbsp;Kimberly S. Canter,&nbsp;Victoria Sardi Brown,&nbsp;Kimberly Buff,&nbsp;Kamyar Arasteh,&nbsp;Emily Pariseau,&nbsp;Eric Sandler,&nbsp;Anne E. Kazak","doi":"10.1002/pbc.31676","DOIUrl":"10.1002/pbc.31676","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Standards for the Psychosocial Care of Children with Cancer and their Families (the Standards) support the provision of evidence-based psychosocial care across the pediatric cancer trajectory by specialized multidisciplinary staff. This paper presents data from the Implementing the Standards Together: Engaging Parents and Providers in Psychosocial care (iSTEPPP) study on the number and type of psychosocial staff at pediatric oncology programs in the United States in 2023, 8 years after the publication of the Standards.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Procedure</h3>\u0000 \u0000 <p>Up to two healthcare professionals from pediatric cancer programs in the United States participated in an online survey. The number and type of psychosocial staff are reported and compared with data from a similar 2016 survey. Challenges in delivering psychosocial care and the impact of the COVID-19 pandemic on staffing are also reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants were clinical leaders from 129 pediatric oncology programs (73 medical and 109 psychosocial providers). Social workers are present in 97.2% of programs and child life specialists in 92.5%. Psychologists (69.2%), neuropsychologists (39.3%), and psychiatrists (15.0%) are less common. There has been some increase in the percentage of programs reporting social workers, psychologists, neuropsychologists, and psychiatrists and in the mean number of psychosocial staff since the Standards were published. Challenges in psychosocial staff are related to funding and are consistent with 2016 data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although most participating pediatric oncology programs have psychosocial staff, many sites continue to lack the size and breadth of multidisciplinary teams needed to implement the Standards.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}