Pediatric Blood & Cancer最新文献

{"title":"Dancing With My Demons.","authors":"Souhridhra Chakraborty","doi":"10.1002/1545-5017.70645","DOIUrl":"10.1002/1545-5017.70645","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70645"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Tracheal Injury Following Tumor Regression in a Child With T-Cell Lymphoblastic Lymphoma.","authors":"Julia Mouradian Barón, Luis H Llano López, Karen Bürcher, Luisina Tejada, Silvio Torres Godoy, Saad Ghafoor, Anita V Arias","doi":"10.1002/1545-5017.70663","DOIUrl":"10.1002/1545-5017.70663","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70663"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECMO Use in Pediatric Oncology and Hematopoietic Stem Cell Transplant Patients: A Descriptive and Comparative Analysis.","authors":"Michelle E Brown, Kalee L Grassia, Jenna O Miller, Caroline R Holton, Erin M Hall, Xuexin Lu, Christopher E Dandoy, Maya L Dewan, Asdis Finnsdottir Wagner","doi":"10.1002/1545-5017.70647","DOIUrl":"10.1002/1545-5017.70647","url":null,"abstract":"<p><strong>Background: </strong>Pediatric oncologic and hematopoietic stem cell transplant (HSCT) recipients are vulnerable to life-threatening illnesses. Extracorporeal membrane oxygenation (ECMO) support as a rescue modality in this population remains controversial. The aim of this study is to describe a large single-center experience with complications and outcomes for pediatric patients with an oncologic diagnosis and/or HSCT on ECMO, and to compare survival outcomes in a smaller multicenter cohort.</p><p><strong>Procedure: </strong>This was a descriptive and comparative observational study. The descriptive analysis, a large single-center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under 18 years old with an underlying oncologic diagnosis and/or HSCT on ECMO. In a small multicenter cohort, the comparative analysis evaluated survival outcomes with respiratory failure in the presence and absence of ECMO. Children's Mercy Kansas City served as the ECMO cohort; Cincinnati Children's Hospital Medical Center served as the matched non-ECMO cohort.</p><p><strong>Results: </strong>Twenty-two ECMO patients were included for the descriptive analysis. Most patients had severe thrombocytopenia, with half developing bleeding complications. Nearly half of patients were neutropenic, and the majority were lymphopenic at ECMO cannulation, with only one neutropenic patient developing a new infection. Twenty-two patients were included (n = 11 ECMO; n = 11 non-ECMO) for the comparative analysis. Calculated oxygenation indices for each cohort were 32.8 and 37.5, and peak inspiratory pressures were 35.5 and 37. The ECMO cohort had 45% of patients survive to hospital discharge compared to 27% of non-ECMO controls (p = 0.659).</p><p><strong>Conclusions: </strong>The findings of this study suggest that bleeding complications and incidence of infections on ECMO are comparable to the general ECMO population. ECMO utilization in pediatric oncologic and HSCT patients with respiratory failure did not offer a survival advantage to conventional PICU management in the setting of a respiratory illness.</p><p><strong>Clinical trials registration number: </strong>NCT07712835.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70647"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148913053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Busulfan-Melphalan Sequencing in Paediatric Solid Tumours: A Pharmacokinetic Signal Beyond Conditioning Sequence.","authors":"Srijib Mukherjee, Christa E Nath, Jacinta L Houng, Melissa Gabriel, Bhavna Padhye, Steven J Keogh","doi":"10.1002/1545-5017.70648","DOIUrl":"10.1002/1545-5017.70648","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70648"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very Late Relapse of Acute Myeloid Leukemia With a Rare HNRNPH1::MLLT10 Fusion Following a Pediatric Myeloid Neoplasm: A Successful Venetoclax-Azacitidine Bridge to Hematopoietic Stem Cell Transplantation.","authors":"Gyuyeon Lee, Kyung Taek Hong, Eun Na Kim, Seon Young Kim, Hyun Jin Park, Bo Kyung Kim, Jung Yoon Choi, Hyoung Jin Kang","doi":"10.1002/1545-5017.70659","DOIUrl":"10.1002/1545-5017.70659","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70659"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENCERT: A Multisite Phase 1 Trial Using Everolimus in Combination With Nelarabine, Cyclophosphamide, and Etoposide in Relapsed T-Cell Lymphoblastic Leukemia/Lymphoma.","authors":"Himalee S Sabnis, Melinda Pauly, Eric S Schafer, Robin E Norris, Kevin Ginn, Tsz Yeung, Naresh Kumar, Stacy Senn, Haley Cowan, Deborah DeRyckere, Christopher J Forlenza, Neerav Shukla","doi":"10.1002/1545-5017.70662","DOIUrl":"10.1002/1545-5017.70662","url":null,"abstract":"<p><strong>Background: </strong>Relapsed and refractory (R/R) T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/T-LL) remains a therapeutic challenge. Allogeneic hematopoietic stem cell transplantation (HSCT) after achieving complete remission (CR) offers the only chance of cure, but effective modalities to achieve CR are limited. Activation of mTOR and PI3K pathways has been well described in T-ALL and monotherapy with mTOR inhibitors has shown efficacy signals used in relapsed disease.</p><p><strong>Methods: </strong>This multisite Phase 1 study evaluated the safety, tolerability, and anti-leukemic activity of everolimus with NEC chemotherapy (nelarabine, etoposide, and cyclophosphamide) among children and young adults with relapsed/refractory T-ALL/T-LL.</p><p><strong>Results: </strong>Eight patients were enrolled to two dose levels (DLs) on this study and no dose-limiting toxicities were reported. Most adverse events related to therapy were expected and hematological. DL2 (n = 5) of everolimus at 5 mg/m²/day was the highest dose tested. The overall response rate (complete response + complete response with incomplete platelet recovery + partial response) was 75% (6/8) with 100% (5/5) responses in the T-ALL cohort and 33% (1/3) responses in T-LL cohort. All six patients who obtained a PR or greater proceeded to receive HSCT as consolidation therapy. Two of the six patients transplanted are alive today with two deaths related to progressive disease and two related to veno-occlusive disease post transplantation.</p><p><strong>Conclusions: </strong>This study demonstrates safety with a combination of everolimus and NEC chemotherapy. Given the observed tolerability and efficacy of everolimus with NEC in this small cohort of patients, this combination should be further evaluated in larger phase 2/3 clinical trials.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT03328104.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70662"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic Hematopoietic Stem Cell Transplantation in RhoG Deficiency: The Second Reported Patient and the First Detailed Transplant Experience.","authors":"Zehra Genç Özbay, Anıl Isık, Gizem Ürel Demir, Elif Soyak Aytekin, Saliha Esenboga, Ali Bülent Antmen, Deniz Cagdas","doi":"10.1002/1545-5017.70633","DOIUrl":"10.1002/1545-5017.70633","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70633"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of v-SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship.","authors":"Anshul Vagrecha, Adit L Tal, Kayleen A Bailey, Andrea D Orsey, Danielle Cohen, Jessica E Briggs, Jeremy Rosenblum, Farzana Pashankar, Katharine Offer, Alexander J Chou, Gabriel Robbins, Kavitha Ramaswamy, Mahvish Q Rahim, Viviana Vidal-Anaya, Jennifer Levine, Prakash Satwani, Scott Moerdler, Joanna Pierro","doi":"10.1002/1545-5017.70686","DOIUrl":"10.1002/1545-5017.70686","url":null,"abstract":"<p><strong>Background: </strong>Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an annual bootcamp in 2022 aimed at easing the transition from pediatric residency to PHO fellowship.</p><p><strong>Methods: </strong>The bootcamp consisted of virtual clinical lectures and fellow-led panels, which were created with input from diverse program leadership, educators, and past fellows using Kern's six-step module of curriculum development. It was offered to incoming fellows, first in the NY/NJ/CT region, and subsequently expanded nationally.</p><p><strong>Results: </strong>Over 4 years (2022-2025), 147 pediatric residents completed this virtual bootcamp. The number of residents attending the live sessions increased from 19 in 2022 to 62 in 2025. Forty-four participants completed pre- and post-bootcamp surveys over this period, which showed significant improvement in both self-reported medical knowledge and preparedness and reported a decrease in transition to fellowship anxiety scores.</p><p><strong>Conclusion: </strong>These results highlight the need and benefits of a standardized orientation program that can be delivered virtually to ease the transition of PHO trainees from residency to fellowship. Such a standardized curriculum is feasible, adaptable, and potentially scalable to a national level.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70686"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Vertebral Malignant Rhabdoid Tumour in Late Childhood: A Clinicopathologic Case Expanding the Osseous Spectrum of Paediatric Rhabdoid Tumours.","authors":"Megadeepan Senthilkumar, Lakshmi T, Rama K, Arun Kumar A R, Prakruthi S Kaushik, Suma Mysore Narayana","doi":"10.1002/1545-5017.70685","DOIUrl":"10.1002/1545-5017.70685","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70685"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate-Induced Epidermal Necrosis in a High-Risk Adolescent Patient.","authors":"Breanna Kooienga, Daniel Bush, Maya Baiyasi, Darius Mehregan, Jeffrey W Taub, Erin Goode","doi":"10.1002/1545-5017.70666","DOIUrl":"10.1002/1545-5017.70666","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70666"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}