Pediatric Blood & Cancer最新文献

{"title":"Blinatumomab-Associated Psychosis in an Adolescent With B-Cell Acute Lymphoblastic Leukemia.","authors":"Eesha A Zaheer, Ashley Holland, Andrew Elliott, Emily Hanzlik, Hiroto Inaba","doi":"10.1002/1545-5017.70231","DOIUrl":"10.1002/1545-5017.70231","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70231"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-Year Follow-Up After Pediatric PBSCT and Living-Donor Lung Transplantation From the Original Donor: Late Benefit of Belumosudil for Chronic GVHD.","authors":"Kensuke Kawaguchi, Shunichiro Toya, Satomi Yokoyama, Tamaki Ueda, Maiko Noguchi, Yusaku Nagatomo, Utako Oba, Kentaro Nakashima, Takeshi Shiraishi, Hideki Nakayama, Yuhki Koga","doi":"10.1002/1545-5017.70209","DOIUrl":"10.1002/1545-5017.70209","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70209"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators and Barriers for Implementing Diagnostic Sequencing Technology for Pediatric Oncology in Low- and Middle-Income Countries.","authors":"Kenneth M Busby, Nathaniel Webb, Javeria Aijaz, Federico Antillon-Klussmann, Vaskar Saha, Rui M Reis, Gevorg Tamamyan, Patricia Alcasabas, Eva Cutiongdo-de la Paz, Jamie Zeal, Dylan Graetz, Nickhill Bhakta, Angelo Navas, Samantha Rubio, Stuart Rennie, Thomas B Alexander, Megan C Roberts","doi":"10.1002/1545-5017.70207","DOIUrl":"10.1002/1545-5017.70207","url":null,"abstract":"<p><strong>Background: </strong>Inaccurate or imprecise diagnosis is a major contributor to treatment failure for children with cancer in low- and middle-income countries (LMICs). Sequencing-based diagnostic testing presents an opportunity to overcome diagnostic deficiencies. It is important to identify facilitators and barriers which are common to the implementation of sequencing-based diagnostics in LMICs.</p><p><strong>Procedure: </strong>Pediatric oncology research collaborators at six hospitals in LMICs were invited to participate in the study. Snowball sampling identified additional participants. Thirty-nine virtual, semi-structured interviews were conducted using interview guides informed by the Consolidated Framework for Implementation Research (CFIR) with suggested adaptations for LMICs. Rapid qualitative analysis was conducted to identify facilitators and barriers to the implementation of diagnostic sequencing for pediatric cancers. Barriers were then matched with expert recommendation for implementation change (ERIC) strategies.</p><p><strong>Results: </strong>Implementation facilitators and barriers were organized by CFIR construct. Predominant facilitators were relative advantage, culture, collective efficacy, self-efficacy, patient needs and resources, leadership engagement, knowledge and beliefs, tension for change, monitoring services for action, and implementation climate. Key barriers to implementation were cost, available resources, resource continuity, engaging participants, and resource source.</p><p><strong>Conclusions: </strong>Participants communicated that the lack of diagnostic classification for pediatric cancer in LMICs is a common key limitation to current cancer care. They described considerable motivating strengths to leverage toward this goal of developing sequencing-based diagnostic testing capacity. Resource availability, continuity, and sustainability are current barriers that must be addressed. Our data highlight the urgent need for creative global implementation partnerships as many centers in LMICs are poised to advance novel diagnostic solutions.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70207"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second Malignancies in Children and Adolescents With Extracranial Germ Cell Tumors: A Report From the Malignant Germ Cell Tumor International Consortium.","authors":"Priya Mahajan, Mark Krailo, Negar Fallahazad, Michelle Nuno, Brice Fresneau, Sara Stoneham, A Lindsay Frazier","doi":"10.1002/1545-5017.70206","DOIUrl":"10.1002/1545-5017.70206","url":null,"abstract":"<p><p>Whilst men with testicular cancer have a twofold increase in second malignant neoplasms (SMNs), the risk in children with germ cell tumors (GCTs) is not fully quantified. SMNs in children treated for GCTs was assessed in the Malignant Germ Cell Tumor International Consortium data commons (n = 917). Thirteen SMNs were identified with median follow-up of only 5.9 years. Assigning cause is nuanced because GCT-related SMNs can either be treatment related, second primary malignancies from a common primordial germ cell progenitor, or somatic malignant transformation of the original GCT. Longer follow-up of children with GCT is needed to ascertain risk and understand causation.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70206"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Incidence and Etiology of Severe Infections in Children Receiving Therapy for High-Risk Neuroblastoma: A Large Single-Center Experience.","authors":"Elio Castagnola, Shana Montalto, Marcello Mariani, Massimo Conte, Stefania Sorrentino, Alessio Mesini, Erica Ricci, Carolina Saffioti, Roberto Bandettini, Emanuela Caci, Francesca Bagnasco, Carlo Dufour, Alberto Garaventa","doi":"10.1002/1545-5017.70203","DOIUrl":"10.1002/1545-5017.70203","url":null,"abstract":"<p><strong>Background: </strong>Severe infections are a leading cause of morbidity and mortality in pediatric oncology, especially among children receiving high-dose chemotherapy. High-risk neuroblastoma (HR-NB) provides a paradigmatic model of prolonged multimodal treatment, yet recent data describing the burden and timing of severe infections during its therapeutic course are limited.</p><p><strong>Procedure: </strong>We retrospectively reviewed 184 consecutive HR-NB patients diagnosed and treated at the IRCCS Istituto Giannina Gaslini (Genoa, Italy) according to the SIOPEN/HR-NBL1 protocol between 2002 and 2021. Severe infectious events were defined as bloodstream infections (BSI) and invasive fungal diseases (IFDs) according to international criteria. Incidence rates per 100 patient-days at risk (pdr) and phase-specific distributions (induction, consolidation, maintenance) were analyzed.</p><p><strong>Results: </strong>Over 80,202 patient-days at risk, 104 severe infections were recorded (cumulative incidence 56.5%). BSI represented 93.3% of events, predominantly Gram-positive (55.8%) and Gram-negative (37.5%) pathogens; 6.7% were IFDs. The induction phase accounted for the highest incidence, while consolidation (hematopoietic stem cell transplantation) showed the highest infection rate per pdr. Approximately 70% of BSI occurred in non-neutropenic patients and were central venous catheter (CVC) related; in neutropenic cases (30%), half were CVC associated. Infection-related mortality was 1.1% (two out of 184).</p><p><strong>Conclusions: </strong>Severe infections remain frequent and clinically significant complications in HR-NB therapy, though infection-related mortality was low. The low incidence of IFDs despite the absence of systematic prophylaxis suggests potential optimization of preventive strategies. These data provide an epidemiologic benchmark for infection risk in the era of immunotherapy and CAR-T approaches for solid tumors.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70203"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Development and Refinement of a Web-Based Sexual Health Education Intervention for Pediatric Oncology Physicians and Advanced Practice Providers Caring for Adolescents and Young Adults With Cancer.","authors":"Natasha N Frederick, Alyssa Bennett, Kristin Bingen, Brooke Cherven, Lydia L Chevalier, Jenna Demedis, David R Freyer, Adrienne Nguyen, Mary-Kate Nowobilski, Trisha Pitter, Gwendolyn P Quinn, Sharon L Bober","doi":"10.1002/1545-5017.70200","DOIUrl":"10.1002/1545-5017.70200","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescent and young adult (AYA) oncology patients demonstrate an expressed need for improved sexual health (SH) communication with oncology clinicians, yet these conversations rarely take place, with clinicians identifying lack of education as a key barrier. This work describes the development and revision of a suite of educational modules aiming to improve clinician SH communication.</p><p><strong>Methods: </strong>Literature review, data collected from prior research by the study team, and expert input from the Children's Oncology Group AYA Sexual Health Task Force were used to develop a series of interactive, online education modules. Clinicians, including physicians and advanced practice providers, were recruited by email across five academic institutions to review the modules and provide feedback through completion of an online open-ended survey. Themes derived from feedback guided module modifications.</p><p><strong>Results: </strong>The initial curriculum consisted of three interactive modules that focused on the importance of addressing SH with AYA patients, how to discuss SH with AYAs, and contraception/safe sex practices during cancer treatment. Fourteen pediatric oncology clinicians reviewed the modules and provided feedback. Collectively, participants described the modules as informative, well-organized, visually appealing, and relevant to clinical practice. Opportunities for improvement included an option to modify the speed of narration, the incorporation of more interactive features to facilitate learner engagement, and the need for additional content on sexual dysfunction.</p><p><strong>Conclusion: </strong>This suite of clinician-focused SH education modules represents a key step in advancing AYA SH care throughout cancer treatment and survivorship. Future work will explore the efficacy of the modules on AYA-clinician SH communication.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70200"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Hematopoietic Stem Cell Transplantation in a Patient With FCHO1 Deficiency.","authors":"Saliha Esenboga, Tamer Dormus, İsmail Yaz, Fatma Visal Okur, Deniz Cagdas, Barış Kuşkonmaz","doi":"10.1002/1545-5017.70140","DOIUrl":"10.1002/1545-5017.70140","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70140"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332.","authors":"Jacquelyn N Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A Barkauskas, Rajkumar Venkatramani, Sheri L Spunt, Aaron R Weiss, Noah C Federman","doi":"10.1002/1545-5017.70228","DOIUrl":"10.1002/1545-5017.70228","url":null,"abstract":"<p><strong>Background: </strong>Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood.</p><p><strong>Methods: </strong>We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332. Patients were treated with risk-adapted therapy, including surgery with or without radiotherapy and ifosfamide and doxorubicin.</p><p><strong>Results: </strong>Twenty-four patients with ASPS enrolled on ARST0332 between 2007 and 2012 were analyzed. The majority of primaries were extremity tumors (71%) and > 5 cm (54%). Nearly half (46%) of patients had metastatic disease at diagnosis, all of whom had primary tumors > 5 cm and pulmonary metastases with or without extrapulmonary metastases. Six patients were evaluable for response to neoadjuvant chemoradiotherapy without an objective response. Estimated 5-year event-free survival (EFS) and overall survival (OS) were 91% and 100% for low-risk (n = 11), 0% and 50% for intermediate-risk (n = 2), and 0% and 59% for high-risk disease (n = 11), respectively. EFS and OS differed significantly by maximal tumor diameter, presence or absence of metastatic disease, risk group, treatment arm, and upfront primary site resection status.</p><p><strong>Conclusions: </strong>Patients with low-risk ASPS (non-metastatic, grossly resected tumors ≤ 5 cm) had excellent outcomes with surgery with or without radiation on ARST0332. Chemotherapy has been reported to be generally ineffective in ASPS and, indeed, there were no objective responses to neoadjuvant chemoradiotherapy on ARST0332. All patients treated with combination chemoradiotherapy ultimately developed disease progression/relapse. A different therapeutic approach is needed for patients with unresectable or metastatic ASPS.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70228"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Challenge in a Child With Recurrent Thrombocytopenia: Cyclic Thrombocytopenia Associated With Immune Dysregulation.","authors":"Ece Koç, Deniz Aslan","doi":"10.1002/1545-5017.70208","DOIUrl":"10.1002/1545-5017.70208","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70208"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Challenging the Odds: Long-Term Survival in Pediatric Diffuse Midline Glioma With H3 K27M and BRAF V600 Co-Mutations Treated With Upfront Radiotherapy and Targeted Therapy\".","authors":"Natália Dassi, Andrea Maria Cappellano","doi":"10.1002/1545-5017.70214","DOIUrl":"10.1002/1545-5017.70214","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70214"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}