对于患有严重再生障碍性贫血的儿童，手术保留生育能力可以安全地进行，而不会延误治疗。

IF 2.3 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-10-20 DOI:10.1002/pbc.32114

Christopher J McCauley, Erin E Rowell, Monica M Laronda, Sara Zarnegar-Lumley

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引用次数: 0

摘要

患有严重再生障碍性贫血（SAA）的儿科患者接受造血细胞移植后发生不孕症的风险显著增加。对于青春期前的儿童，移植前生育能力保存（FP）的选择是外科手术：卵巢或睾丸组织冷冻保存（OTC和TTC）。出血和感染的风险必须考虑到这些患者严重的细胞减少。我们从2015年到2023年在我们的机构前瞻性地招募患者参加外科FP临床方案。我们评估了所有14例SAA患者接受手术FP的方法和结果（TTC: n = 7; OTC: n = 7）。没有患者出现与FP相关的手术并发症。在我们的患者队列中，利用综合标准护理途径安全地实现了手术FP。

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Surgical Fertility Preservation can be Safely Performed Without Delaying Treatment for Children With Severe Aplastic Anemia.

Pediatric patients with severe aplastic anemia (SAA) who undergo hematopoietic cell transplantation are at significantly increased risk of infertility. Pretransplant fertility preservation (FP) options for prepubertal children are surgical procedures: ovarian or testicular tissue cryopreservation (OTC and TTC). Bleeding and infection risk must be considered given profound cytopenias in these patients. We prospectively enrolled patients in a surgical FP clinical protocol at our institution from 2015 to 2023. We evaluated the approach and outcomes of all 14 patients with SAA who underwent surgical FP (TTC: n = 7; OTC: n = 7). No patients experienced a surgical complication related to FP. With our patient cohort, surgical FP was safely achieved utilizing a comprehensive standard of care pathway.

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.