Pediatric Blood & Cancer最新文献

{"title":"A Modified Three-Step Haploidentical Transplantation With TCRαβ/CD62L Depletion for Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis and Natural Killer-Cell Lymphoproliferative Disease.","authors":"Wilson Y K Chan, Pamela P W Lee, Daniel K L Cheuk, Alan K S Chiang, Wing Leung","doi":"10.1002/pbc.31818","DOIUrl":"https://doi.org/10.1002/pbc.31818","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31818"},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Local Control of Clear Cell Sarcoma With Carbon Ion Radiotherapy.","authors":"Kosuke Kuwahara, Yusuke Hara, Genki Yamato, Jun Kawashima, Haruna Okuno, Sayaka Otake, Ayako Yamazaki, Nozomi Matsumura, Hideaki Yokoo, Daijiro Kobayashi, Yuhei Miyasaka, Masahiko Okamoto, Takumi Takizawa","doi":"10.1002/pbc.31807","DOIUrl":"https://doi.org/10.1002/pbc.31807","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31807"},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It Takes a Village and More: First Report of Successful Allogeneic Hematopoietic Cell Transplantation for Hepatopulmonary Syndrome Associated With Chronic Active Epstein-Barr Virus Disease.","authors":"Prakash Satwani, Usha S Krishnan, Alexis Boneparth, Lisa Imundo, Ellen Shaw, Andrei Constantinescu, Amanda Cantor, Diane George, Cindy Neunert, Pawel Muranski, Fangming Lin, Joshua D Milner, Monica Bhatia","doi":"10.1002/pbc.31821","DOIUrl":"https://doi.org/10.1002/pbc.31821","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31821"},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YAP1-MAML2 Fusion in Young Children with Pediatric High-Grade Glioma: A Case Report.","authors":"Nina Thomson, Emily Jewels, Samuel Bergeron-Gravel, Simon Lagacé, Lili-Naz Hazrati, Stephen Saikali, Christopher Dunham, Sylvia Cheng","doi":"10.1002/pbc.31796","DOIUrl":"https://doi.org/10.1002/pbc.31796","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31796"},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Bromide Levels due to Tazemetostat Therapy Treated With Salt and Water Supplementation in Two Children With Atypical Teratoid Rhabdoid Tumor.","authors":"Thomas J Galletta, Stefanie W Benoit, Justin Markham, Natasha Pillay-Smiley, Kate Queen, Richard T Graham","doi":"10.1002/pbc.31803","DOIUrl":"https://doi.org/10.1002/pbc.31803","url":null,"abstract":"<p><p>Atypical teratoid rhabdoid tumor (ATRT) is an embryonal CNS tumor that afflicts young children. The molecular process associated with ATRT is loss of SMARCB1 or SMARCA4, which causes EZH2 overactivation. Tazemetostat hydrobromide is an EZH2 inhibitor, which has shown efficacy in the treatment of ATRT. Tazemetostat is produced as a bromide salt and can cause increased bromide levels that may require therapy cessation or dose reduction. We report two children with ATRT, who developed elevated bromide levels secondary to tazemetostat, which were treated with chloride. We propose consideration of salt supplementation in children receiving tazemetostat to prevent bromide elevation and pauses or reductions in therapy.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31803"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Concurrent Neuroblastoma and Acute Myeloid Leukemia With CBFA2T3::GLIS2 Fusion: A Diagnostic and Therapeutic Dilemma.","authors":"Laura M Molina, Nathanael Bailey, Majd Jawad, Pranav P Patwardhan, Erika Friehling, Kelly Bailey, Randy M Windreich, Ahmad Al-Attar, Katelynn Davis, Catherine K Gestrich","doi":"10.1002/pbc.31815","DOIUrl":"https://doi.org/10.1002/pbc.31815","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31815"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Safety Practices and Foodborne Illness in Italian Pediatric Oncology and Hematology Centers: A Survey on Behalf of the Infectious Disease Working Group of AIEOP.","authors":"Davide Leardini, Gianluca Bossù, Francesco Venturelli, Francesco Baccelli, Edoardo Muratore, Antonio Grasso, Pietro Gasperini, Chiara Pilotto, Letizia Pomponia Brescia, Nagua Giurici, Angelica Barone, Mariacristina Menconi, Elena Soncini, Daniela Onofrillo, Manuela Spadea, Francesco Fabozzi, Pietro Casartelli, Simona Rinieri, Maria Grazia Petris, Valeria Petroni, Paola Muggeo, Katia Perruccio, Cristina Meazza, Francesca Compagno, Francesco Paolo Tambaro, Maura Faraci, Angela Mastronuzzi, Riccardo Masetti, Simone Cesaro","doi":"10.1002/pbc.31782","DOIUrl":"https://doi.org/10.1002/pbc.31782","url":null,"abstract":"<p><strong>Background: </strong>Food safety practices are widely recommended for pediatric patients with cancer or undergoing hematopoietic stem cell transplantation (HCT) to mitigate foodborne infectious risks. However, specific measures, such as the neutropenic diet (ND) or low-microbial diet, lack robust evidence and are inconsistently implemented across pediatric hematology-oncology centers. Additionally, data on foodborne illnesses (FBI) in this population remain scarce.</p><p><strong>Procedure: </strong>We conducted an online survey and a retrospective review of FBI cases across 22 centers within the Italian Association of Pediatric Hematology and Oncology (AIEOP) network, 13/22 performing allogeneic HCT.</p><p><strong>Results: </strong>All centers provide dietary recommendations to the patients. Restrictive diets are recommended in 72% of centers during hospitalization and in 77% after discharge. Universally avoided foods include unpasteurized milk, fresh fruit without skin, moldy cheeses, bakery and ice cream products, raw eggs and derivatives, raw meat, raw or smoked fish, cured meats, shellfish, and cooked food leftovers. Fresh fruits and vegetables are commonly restricted only to patients undergoing allogeneic HCT. Ninety-five percent of centers provide patients and their families with guidelines on cleaning food at home, including thorough cleaning of fruits and vegetables with a food disinfectant. Seven centers reported FBI cases, with eight documented cases, including two fatalities caused by meningoencephalitis related to infections from Listeria monocytogenes and Bacillus cereus, respectively.</p><p><strong>Conclusions: </strong>This study highlights the need for standardized, evidence-based food safety guidelines and FBI management to enhance care for pediatric patients receiving chemotherapy or HCT.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31782"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic Hematopoietic Stem Cell Transplant for an Unknown Inherited Bone Marrow Failure Syndrome with a Novel Compound Heterozygous Mutation.","authors":"Olayinka Okeleji, Sajad Khazal, Kris M Mahadeo, Dristhi Ragoonanan, Nidra Rodriguez, Courtney DiNardo, Jeremy Connors, Demetrios Petropoulos, Priti Tewari, Irtiza N Sheikh","doi":"10.1002/pbc.31817","DOIUrl":"https://doi.org/10.1002/pbc.31817","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31817"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series.","authors":"Michael R Sargen, Madeline H Fitzhugh, Jennifer S Ko, Allison G Close, Sara C Horton, Faizan Malik, Larissa V Furtado, Armita Bahrami, Brittani K N Seynnaeve, Alberto S Pappo, Vincent Liu, Kevin Cheung, Svetlana D Pack, Liqiang Xi, Mark Raffeld, Ina Lee, Jeffrey Gagan, Kenneth Aldape, Frederic G Barr, Stephen M Hewitt, Christina K Ferrone, Anna Hayden, Jessica N Hatton, Alisa M Goldstein, Ruth M Pfeiffer, Brigitte Widemann, Mary Frances Wedekind Malone, Andrea M Gross, Rosandra Kaplan, Marielle E Yohe, Kristen G Berrebi","doi":"10.1002/pbc.31814","DOIUrl":"https://doi.org/10.1002/pbc.31814","url":null,"abstract":"<p><p>Limited information is available on the clinicopathologic features and management of pediatric CRTC1::TRIM11 (CTRTs) and MED15::ATF1-rearranged tumors (MARTs). In this series of pediatric CTRTs (n = 5) and MARTs (n = 2), all tumors exhibited spitzoid morphology and expressed melanocytic markers. Metastatic progression occurred in one CTRT and two MARTs: all three received immunotherapy, resulting in disease control in two patients and one death due to progressive disease. A fourth individual had lymph node micrometastasis that remained stable without progression. This case series highlights the potentially aggressive behavior of these tumors and suggests that immunotherapy may be an effective treatment option for advanced disease.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31814"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Absolute Neutrophil Counts of Children With Sickle Cell Disease With and Without the Duffy Null Phenotype.","authors":"Nate Goldfarb, Joseph Stanek, Joseph Walden, Melissa J Rose, Kathleen Nicol, Anthony Villella, Jennifer Young, Susan Creary","doi":"10.1002/pbc.31794","DOIUrl":"https://doi.org/10.1002/pbc.31794","url":null,"abstract":"<p><p>While nonpathogenic, the Duffy null phenotype (DN) lowers circulating neutrophils. DN is common among youth with sickle cell disease (SCD), but its implications on absolute neutrophil counts (ANC) and hydroxyurea over time are unclear. Our retrospective review found that all children who were not receiving hydroxyurea had stable ANC through age 9 years, but those with DN had lower mean ANC starting at 6 years of age. Among hydroxyurea users, ANC increased over time, regardless of DN status, suggesting opportunities to optimize hydroxyurea. Future studies of hospitalized and older individuals are needed to further examine DN's impact on people with SCD.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31794"},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}