Pediatric Blood & Cancer最新文献_第3页

Platelet Counts Prior to Lymphodepletion Chemotherapy are Associated with Clinical Outcome in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia After CAR-T19-Cell Therapy.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-20 DOI: 10.1002/pbc.31604

Nazaret Sanchez-Sierra, Anna Alonso-Saladrigues, Sara Perez-Jaume, Cristina Rivera-Perez, Anna Faura, Laura Arques, Ignacio Mario Isola, Montserrat Torrebadell, Jose Luis Dapena Diaz, Susana Rives

引用次数: 0

After 75 Years of Methotrexate, Can Treatment Results be Improved with Appropriate Folinic Acid Rescue?

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-20 DOI: 10.1002/pbc.31608

Ian J Cohen

引用次数: 0

Severe Precapillary Pulmonary Hypertension and Right Ventricular Failure After Hematopoietic Stem Cell Transplantation: Successful Outcomes With Aggressive Upfront Triple Therapy.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-20 DOI: 10.1002/pbc.31623

Stine Andersen, Jesper Vandborg Bjerre, Karin Bækgaard, Lars Idorn, Mads Jønsson Andersen

引用次数: 0

Variants of Uncertain Significance in Vascular Anomalies: The Role of Reclassification.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-20 DOI: 10.1002/pbc.31610

Julie Blatt, Clara Hildebrandt, Elizabeth Nieman, Michael C Adams, Lucy McNamee, Alexandra J Borst

{"title":"Variants of Uncertain Significance in Vascular Anomalies: The Role of Reclassification.","authors":"Julie Blatt, Clara Hildebrandt, Elizabeth Nieman, Michael C Adams, Lucy McNamee, Alexandra J Borst","doi":"10.1002/pbc.31610","DOIUrl":"https://doi.org/10.1002/pbc.31610","url":null,"abstract":"Background: Vascular anomalies (VA) are rare developmental disorders due to somatic variants in intracellular growth signaling pathways. Although genetic evaluation is considered the standard of care for optimizing management, the frequency of variants of uncertain significance (VUS) in VA and their clinical implications are not defined.Methods: Medical records were reviewed on all patients seen in our VA clinic from January 2014 to August 2024 with vascular malformations or related disorders who had undergone genetic testing. The year and patient age at the time of genetic testing, whether testing was done on peripheral blood or involved tissue, and results were noted. Laboratory vendors were queried about policies for reclassifying VUS and selective re-evaluations of VUS were requested.Results: In all, 154 patients underwent single gene or gene panel evaluations, with the number of patients tested increasing from zero in 2014 to 39 in 2023; 21 patients had testing done during the first 7 months of 2024. VUS were reported in 22 patients (14%). Many laboratory vendors maintain a policy of revisiting these nonpathogenic variants only when requested by the treating physician. Unsolicited reclassification was reported in a single patient whose VUS was found to be a normal variant. No changes were identified in six other patients whose VUS were re-examined.Conclusions: VUS are not uncommon in VA. Reclassification may be possible as more variant-specific data become available and more testing is performed. Centers need to be aware that reclassification efforts are not automatic and should be considered where changes in therapy might result.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31610"},"PeriodicalIF":2.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing Behavior Change Model-Informed and Participant-Engaged Retention Strategies for Adolescents and Young Adults With Cancer Enrolled on Behavioral and/or Psychosocial Trials.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-17 DOI: 10.1002/pbc.31583

Meghan E McGrady, Rachel Tillery Webster, Macks Burke, Chelsey Gomez, Gabriella Breen, Julia K Herriott, Robin E Norris, Tyler G Ketterl

引用次数: 0

Fava Bean- Versus Non-Fava Bean-Induced Acute Hemolytic Crisis in Children with Glucose-6-Phosphate Dehydrogenase Deficiency: A Prospective Comparative Study.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-16 DOI: 10.1002/pbc.31609

Gowda Parameshwara Prashanth, Mohammed Al-Shafey, Anita Tandon, Salim Ismail

{"title":"Fava Bean- Versus Non-Fava Bean-Induced Acute Hemolytic Crisis in Children with Glucose-6-Phosphate Dehydrogenase Deficiency: A Prospective Comparative Study.","authors":"Gowda Parameshwara Prashanth, Mohammed Al-Shafey, Anita Tandon, Salim Ismail","doi":"10.1002/pbc.31609","DOIUrl":"https://doi.org/10.1002/pbc.31609","url":null,"abstract":"Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a red cell enzymopathy in which exposure to oxidative stressors, such as drugs or fava bean ingestion, can trigger acute hemolytic episodes (AHEs). This study aimed to compare the clinical characteristics of fava bean-induced hemolysis (FBIH) with non-fava bean-induced hemolysis (NFBIH) in children with G6PD deficiency in a high-prevalence setting.Methods: A prospective cohort study was conducted at a region referral hospital in Oman. Hospital records of children hospitalized for AHE due to G6PD deficiency over a 3-year period were analyzed. Participants were categorized into FBIH and NFBIH groups based on the documented precipitating factor.Results: Among the 236 recruited cases, 51.6% AHEs were attributed to FBIH. Children with FIBH were younger, more likely to present with abdominal pain, and had greater severity of hemolysis upon admission (hemoglobin: 4.8 vs. 6.7 g/dL; p < 0.001). Lab markers such as serum ferritin, blood urea, lactate dehydrogenase, and alkaline phosphatase were significantly elevated in FBIH. The least squares regression model demonstrated a strong link between various predictor variables and hemoglobin levels, explaining about 76.6% of the variance in the study cohort.Conclusion: Children with FBIH experience more severe hemolytic episodes compared to those with NFBIH. Our statistical model identified clinical and laboratory parameters potentially useful in early risk stratification during AHEs. Culturally sensitive dietary education of patients and caregivers is necessary, particularly in regions where fava beans are a dietary staple. The potential influence of specific G6PD genotypes within the NFBIH group merits future investigation.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31609"},"PeriodicalIF":2.4,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEK Inhibition With Trametinib for the treatment of MAP2K1-Mutated Rosai-Dorfman-Destombes Disease Arising from the Nasopharynx in a Paediatric Patient.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-16 DOI: 10.1002/pbc.31595

Claire Cuerden, Mohammad Alsalem, Eleanor Sproson, Andrea Burgess, Sanjay Jogai, Howard Portess, Karen Deem, Hasnaa Ismail-Koch, Oussama Abla, Jessica Bate

引用次数: 0

Osteosarcoma in an Adolescent With Germline DYNC1H1-Related Disorder: A Novel Association With Whole Genome and Transcriptome Tumour Analysis.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-14 DOI: 10.1002/pbc.31592

Cameron J Grisdale, Rachel V Silverberg, Bilal M Marwa, Trevor J Loback, Alysa A Poulin, Kaveer K Chatoorgoon, Saima Alvi, Shahrad R Rassekh, Rebecca J Deyell, Paul R D'Alessandro

引用次数: 0

Factors Associated with Electrocardiographic Abnormalities in Patients with Sickle Cell Disease: A Systematic Review and Meta-Analysis.

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-14 DOI: 10.1002/pbc.31585

Parisa Zare, Alireza Ahmadkhani, Ehsan Taherifard, Shant Apelian, Hoda Behjoo, Erfan Taherifard

{"title":"Factors Associated with Electrocardiographic Abnormalities in Patients with Sickle Cell Disease: A Systematic Review and Meta-Analysis.","authors":"Parisa Zare, Alireza Ahmadkhani, Ehsan Taherifard, Shant Apelian, Hoda Behjoo, Erfan Taherifard","doi":"10.1002/pbc.31585","DOIUrl":"https://doi.org/10.1002/pbc.31585","url":null,"abstract":"Introduction: Sickle cell disease (SCD) is frequently associated with cardiovascular complications, with cardiac involvement being evident in the electrocardiogram (ECG). This study aimed to systematically research the literature to investigate factors associated with ECG abnormalities in SCD patients.Method: Five online databases of PubMed, Scopus, Web of Science, Embase, and Google Scholar were reviewed using a broad search strategy to identify original studies reporting factors associated with abnormal ECG findings among patients with SCD. Using Comprehensive Meta-Analysis software, various effect sizes-odds ratios (ORs), mean differences, and correlation coefficients-were analyzed, pooled with a random effects model, and visualized through forest plots.Results: Data analysis from 23 studies covering 2943 SCD patients revealed increased odds of prolonged QTc interval (2.54, 95% CI = 1.34-4.83), ST segment elevation (9.23, 95% CI = 3.15-27.07), and ST segment depression (3.82, 95% CI = 1.99-7.33) during crises. Patients with moderate SCD severity had higher odds of having any ECG abnormalities compared to those with mild severity (2.80, 95% CI = 1.47-5.33). No significant associations were observed between moderate and mild severity for left ventricular hypertrophy, sinus arrhythmia, and sinus tachycardia, or between male and female for having any ECG abnormalities, left ventricular hypertrophy, and prolonged QTc interval. Additionally, mean hemoglobin level was 0.60 mg/dL lower (95% CI = -0.91 to 0.28) in those with prolonged QTc interval.Conclusion: This study highlights the link between SCD status and severity, and hemoglobin, and ECG abnormalities. It emphasizes the need for cardiac monitoring, caution with QTc-prolonging medications, and routine ECG assessments to prevent cardiovascular complications in these high-risk patients.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31585"},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Outcomes of Relapsed Favorable-histology Wilms Tumor in Non-clinical Trial Setting". 对 "在非临床试验环境中复发的好发组织学 Wilms 肿瘤的疗效 "的更正。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-02-14 DOI: 10.1002/pbc.31601

引用次数: 0