Pediatric Blood & Cancer最新文献

{"title":"Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant.","authors":"Matthew R Schuelke, Julia Wang, Haley Newman, Evelyn Kurpiewski, Anne Reilly, Susan R Rheingold, Gerald Wertheim, Moe Takeda, Daniel J Zheng, Kaitlin Devine","doi":"10.1002/1545-5017.70622","DOIUrl":"10.1002/1545-5017.70622","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70622"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society of Paediatric Oncology (SIOP) Global Mapping Programme of Pediatric Oncology Services: Data Collection in India.","authors":"Amita Trehan, Emine A Rahiman, Jennifer Lowe, Maite Gorostegui, Scott Howard, Neil Ranasinghe, Julia Challinor, Nita Radhakrishnan","doi":"10.1002/1545-5017.70667","DOIUrl":"10.1002/1545-5017.70667","url":null,"abstract":"<p><strong>Background: </strong>The International Society of Paediatric Oncology launched the Global Mapping Programme in 2018 to systematically map pediatric oncology services worldwide. Objectives were to document regional resources, maintain a publicly accessible stakeholder map, engage key stakeholders, and strengthen referral pathways. India, the world's most populous country (1.45 billion), has nearly 25% of its population under 15 years. The healthcare system, disparities in resources, access, and cost leave the true childhood cancer burden inadequately defined. Mapping pediatric cancer units (PCUs) is critical to identify the strengths and gaps and help policymakers, non-governmental organizations, funders, and clinicians. The data collection processes developed for mapping India are detailed in this report.</p><p><strong>Procedure: </strong>The Pediatric Hematology Oncology Chapter of the Indian Academy of Pediatrics developed a 98-item survey to assess infrastructure, resources, and support systems. Designed to capture the heterogeneity of healthcare, it is the most extensive survey conducted within any Global Mapping Programme region. Launched in December 2023, it targeted approximately 150 PCUs, with responses limited to one per hospital.</p><p><strong>Results: </strong>The survey closed in December 2024 with 133 responses, covering most centers, although some non-response remains a limitation.</p><p><strong>Conclusions: </strong>National cancer control policies in India have given limited attention to children. The mapping data can guide alignment with the World Health Organization Global Initiative for Childhood Cancer and support progress toward the CureAll framework goal of 60% survival. Achieving this goal requires coordinated central and state action to address gaps in workforce, resources, and family support, along with periodic reassessment of capacity in pediatric oncology.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70667"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change.","authors":"Raymond B Mailhot Vega, Daniel J Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail-Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero-Mendez","doi":"10.1002/1545-5017.70644","DOIUrl":"10.1002/1545-5017.70644","url":null,"abstract":"<p><strong>Background: </strong>We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior.</p><p><strong>Methods: </strong>We developed and distributed a 121-question survey to radiation oncologists, medical physicists and radiologists from participating Member States (MSs). It included questions on radiation oncology, imaging, nutrition, human capacity to support these services, quality assurance practices and other aspects of childhood cancer management. Questions evaluated practices, access, standards and other topics specific to childhood cancer care.</p><p><strong>Results: </strong>Forty-seven IAEA MSs completed the survey. Regardless of country income level, most institutions had departments providing essential services of paediatric oncology, anaesthesia and radiology. Disparities in access exist regarding nuclear medicine, advanced diagnostic and interventional radiology, linear accelerators, quality assurance and services for patients and families favouring higher-income countries. Medical physics presence for radiation oncology was consistent across income level, whereas access to it was scarce. Regarding diagnostic imaging, most respondents reported access to computed tomography but access to other advanced imaging technologies was limited.</p><p><strong>Conclusions: </strong>While there have been improvements in access to certain aspects of paediatric cancer care compared to the previous survey, disparities persist, particularly in low- and middle-income countries. There is a need for more specialized training, better access to imaging and RT technology, and improved ancillary services. These findings can inform policy and decision-making authorities towards the WHO's 2030 goal for childhood cancer.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70644"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent Unilateral Retinoblastoma in a Low- and Middle-Income Country: Diagnostic Challenges and Barriers to Genetic Cancer Care.","authors":"Saliha Sarfraz, Shaarif Bashir, Sana Munir Gill, Aruba Nawaz Khattak","doi":"10.1002/1545-5017.70673","DOIUrl":"10.1002/1545-5017.70673","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70673"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap Between Molecular Profiling and Precision Therapy in Pediatric Central Nervous System Tumors.","authors":"Emma Horowitz, Rose Parisi, Gavrielle Rood, Acacia Bowden, David Byrwa, Roshal R Patel, George Turco, David Korones, Jeffrey Andolina, Melanie Comito, Matthew Barth, Lauren Weintraub","doi":"10.1002/1545-5017.70687","DOIUrl":"10.1002/1545-5017.70687","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70687"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remdesivir for Adenovirus After Hematopoietic Stem Cell Transplant.","authors":"Feargal Donaghy, Sara Bear, Steven J Siegel, Nicholas J Gloude, Hojun Li, Seth Rakoff-Nahoum","doi":"10.1002/1545-5017.70658","DOIUrl":"10.1002/1545-5017.70658","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70658"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Ovarian Reserve in Female Adolescents/Young Adults With Lymphoma: A Report From Children's Oncology Group Study ALTE11C1.","authors":"Lindsay F Schwartz, Clarisa R Gracia, Venkatraman E Seshan, Jill P Ginsberg, Richard Aplenc, Genevieve Sylvain, Debra L Friedman, Saro H Armenian, Lillian R Meacham, Eric J Chow, Jennifer M Levine","doi":"10.1002/1545-5017.70641","DOIUrl":"10.1002/1545-5017.70641","url":null,"abstract":"<p><strong>Background: </strong>Children's Oncology Group (COG) study ALTE11C1 prospectively evaluated ovarian reserve in female adolescents/young adults (AYAs) with lymphoma from diagnosis to 1 year post-end of treatment (EOT). Healthy peers provided normative comparisons.</p><p><strong>Procedure: </strong>From 2013 to 2018, female participants ≥6 months post-menarche with newly diagnosed lymphoma were enrolled at COG institutions, along with healthy peers. All completed study entry questionnaires and menstrual cycle-independent blood draws for anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol; lymphoma participants had four additional draws during and after treatment. Associations between biomarkers, disease and treatment characteristics were evaluated. Logistic regression and recursive partitioning analyses identified predictors of diminished ovarian reserve (DOR: AMH <1 ng/mL) at 1 year post-EOT.</p><p><strong>Results: </strong>Analyses included 168 participants and 125 healthy peers. Participants had lower AMH than healthy peers at study entry (2.1 vs. 4.1 ng/mL; p < 0.01) and 1 year post-EOT (1.7 vs. 4.1 ng/mL; p < 0.01). AMH declined during treatment, with partial recovery post-EOT to below study entry levels (p < 0.01). Those with advanced stage Hodgkin lymphoma and/or B symptoms had the lowest AMH. By 1 year post-EOT, 34% had DOR; study entry AMH less than 1 ng/mL (p = 0.003) and higher alkylator exposure (p = 0.01) were independent predictors. Most participants with study entry AMH less than 1 ng/mL (76%) or CED ≥6.6 g/m² (75%) demonstrated DOR at 1 year post-EOT. No participant had acute ovarian failure at 1 year post-EOT.</p><p><strong>Conclusions: </strong>Lymphoma and its treatments affect ovarian reserve in female AYA patients. Low AMH at diagnosis and high alkylator exposure predict post-therapy DOR and can guide fertility preservation counseling.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70641"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Three-Component Immune Framework Stratifies Treatment Response and Escalation in Pediatric Hemophagocytic Lymphohistiocytosis: A Prospective Single-Center Cohort Study.","authors":"Mai Anh Thi Nguyen, Truong Nhat Trinh, Duong Ngoc Mai, Phung Nguyen The Nguyen","doi":"10.1002/1545-5017.70654","DOIUrl":"10.1002/1545-5017.70654","url":null,"abstract":"<p><strong>Background: </strong>Pediatric hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome that can be classified into three principal etiologies (primary HLH [pHLH], Epstein-Barr-virus-driven HLH [EBV-HLH], and secondary HLH [sHLH]) and is associated with disparate outcomes. Treatment escalation decisions remain largely empirical, guided by clinical presentation and conventional laboratory results rather than by an integrated biomarker framework.</p><p><strong>Procedure: </strong>We prospectively enrolled 180 consecutive pediatric patients with HLH at Children's Hospital 1, Ho Chi Minh City, Vietnam (October 2022-October 2025): pHLH, n = 40; EBV-HLH, n = 46 (CD27 intact, n = 19; CD27 dim, n = 27); and sHLH, n = 94. A 15-analyte multiplex cytokine panel and six-marker lymphocyte subset flow cytometry were performed at diagnosis (T0) and Day 7 (T1). Logistic regression models were developed and internally validated using bootstrap optimism correction (1000 iterations), 5-fold stratified cross-validation, and a temporal split.</p><p><strong>Results: </strong>Overall mortality was 31.1% (EBV-HLH 67.4%, pHLH 45.0%, and sHLH 7.4%). Three discrete cytokine and subset phenotypes emerged: EBV-HLH showed massive elevations in IFN-γ and sCD25, with profound CD4+ and double-negative T-cell depletion; pHLH showed elevated tumor necrosis factor-α with preserved subsets; sHLH had low-amplitude profiles with the highest CD4+ counts. Day-7 IFN-γ T1/T0 ratio (threshold 0.376) stratified mortality 6- to 27-fold within each etiology. Cytokine drivers of escalation were etiology specific (sCD25 in pHLH, sCD25+IL-18 in EBV-HLH, and IL-10/IL-6 in sHLH). The integrated three-component model achieved an apparent AUC of 0.963, a bias-corrected AUC of 0.947 (95% CI: 0.92-0.97), a 5-fold CV AUC of 0.942 ± 0.05, and a temporal validation AUC of 0.946-all three methods were convergent.</p><p><strong>Conclusions: </strong>Integrating etiology, cytokine phenotype, and lymphocyte subset profile provides biology-grounded prediction of mortality and treatment escalation in pediatric HLH. Multicenter external validation is the next essential step.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70654"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor-Derived CD19-CAR-T Therapy in Combination With TKI Cures Uncommon Ph-Like Mixed-Phenotype Acute Leukemia With Lineage Switch to Ph⁺ Acute Lymphoblastic Leukemia: A Case Report.","authors":"Xia Chen, Fang Liu, Yuanyuan Ren, Yumei Chen, Yao Zou, Li Zhang, Xiaojuan Chen, Xiaofan Zhu, Ye Guo, Wenyu Yang","doi":"10.1002/1545-5017.70681","DOIUrl":"10.1002/1545-5017.70681","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70681"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ovarian and Multivisceral Involvement as the Initial Presentation of T-Cell Acute Lymphoblastic Leukemia in a 3-Year-Old Child: An Exceptionally Rare Case.","authors":"Samir Iddir, Brahim Lounis, Zakia Batoul Benlahreche","doi":"10.1002/1545-5017.70675","DOIUrl":"10.1002/1545-5017.70675","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70675"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}