Pediatric Blood & Cancer最新文献_第4页

Inequities in Pediatric Cancer: Unveiling the Impact of Social Determinants of Health on Survival. 儿童癌症的不公平：揭示健康对生存的社会决定因素的影响。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-06 DOI: 10.1002/pbc.31742

Charbel Chidiac, Pallavi Menon, Mark B Slidell, Shaun M Kunisaki, Alejandro V Garcia, Daniel S Rhee

{"title":"Inequities in Pediatric Cancer: Unveiling the Impact of Social Determinants of Health on Survival.","authors":"Charbel Chidiac, Pallavi Menon, Mark B Slidell, Shaun M Kunisaki, Alejandro V Garcia, Daniel S Rhee","doi":"10.1002/pbc.31742","DOIUrl":"https://doi.org/10.1002/pbc.31742","url":null,"abstract":"Background: The implications of sociodemographic factors across a wide range of pediatric cancers remain unclear. This study aims to assess the impact of social determinants of health (SDOH) on the survival rates of children diagnosed with cancer.Methods: This retrospective cohort study included children <18 years with cancer in the National Cancer Database (2004-2020). Cancers included were central nervous system (CNS) tumors, leukemia, lymphoma, and non-CNS solid tumors. The primary outcome was five-year overall survival (5-OS). Kaplan-Meier curves and multivariable Cox proportional regression were employed.Results: Of 132,076 children (median age 8 years), 14.8% had CNS tumors, 47.4% leukemia/lymphoma, and 37.8% had non-CNS solid tumors. The median follow-up was 67.3 months. 5-OS was lower in Black (78.9% vs. 84.9%, p < 0.001) and Hispanic (82.1% vs. 84.3%, p < 0.001) children, and those publicly insured (82.1%) and noninsured (80.2%) compared with privately insured (85.8%) (p < 0.001). On multivariable analysis, factors associated with increased hazard of death were Black race (aHR 1.28, 95% CI 1.23-1.34), Hispanic ethnicity (aHR 1.08, 95% CI 1.03-1.12), areas with <93% parental high school graduation (aHR 1.20, 95% CI 1.14-1.25), median household income <$63,331 (aHR 1.11, 95% CI 1.06-1.16), nonprivate insurance (aHR 1.16, 95%CI 1.12-1.20), no insurance (aHR 1.36, 95% CI 1.24-1.49), living in rural/urban areas (aHR 1.05, 95% CI 1.01-1.10) and living ≥60 miles from the treating facility (aHR 1.20, 95% CI 1.15-1.24).Conclusions: SDOH are associated with disparities in pediatric cancer survival rates. Targeted strategies to enhance care for Black and Hispanic children, as well as those with limited access due to insurance and travel distance, are essential for achieving equitable outcomes for all pediatric cancer patients.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31742"},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sickle Cell Story Club: Implementation of a Clinic-Based Literacy Promotion Program. 镰状细胞故事俱乐部：实施以诊所为基础的扫盲促进计划。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-05 DOI: 10.1002/pbc.31755

Julia E LaMotte, Jillian R Bouck, Kristen Pogue, Lauren Fancher, Olivia Coughlin, Seethal A Jacob

{"title":"Sickle Cell Story Club: Implementation of a Clinic-Based Literacy Promotion Program.","authors":"Julia E LaMotte, Jillian R Bouck, Kristen Pogue, Lauren Fancher, Olivia Coughlin, Seethal A Jacob","doi":"10.1002/pbc.31755","DOIUrl":"https://doi.org/10.1002/pbc.31755","url":null,"abstract":"Background: Literacy promotion is central to child development, particularly for children with sickle cell disease (SCD) given patterns of neurocognitive involvement. Book ownership programs offer a unique strategy within pediatric healthcare. This study aimed to evaluate the implementation of a literacy promotion program within an outpatient pediatric subspecialty clinic.Procedure: The Sickle Cell Story Club (SCSC) distributed books from March 2021 to December 2023 in an outpatient comprehensive SCD clinic. Families completed home literacy and feedback surveys when receiving a book. Books were provided regardless of data completion and could be refused at any time.Results: A total of 1711 books were distributed to 386 patients (0-22 years), with an average of four books per patient (range = 1-12 books). Most books were given by psychosocial team members (94.87%). Caregivers of young children (0-5 years) read more (68.8%) as a result of the SCSC, and all found the program to be useful for reading development. Caregivers of school-aged children (6-12 years) observed a positive impact of the SCSC on their child's reading confidence (86.8%). Caregivers of school children and adolescents (13+ years) agreed that the SCSC increased the frequency of reading behaviors as well as enjoyment toward reading. Nearly all families were likely to recommend the SCSC (90.1%).Conclusion: Given the neurocognitive impact and known disparities in educational resources, patients with SCD are at a unique risk for differences in learning. Literacy promotion is imperative to child development and a chronic disease subspecialty clinic offers a unique opportunity to address this domain.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31755"},"PeriodicalIF":2.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs. 儿童免疫性血小板减少症的治疗前景：解决未满足的需求。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-05 DOI: 10.1002/pbc.31758

Joana Azevedo, Jennifer DiRaimo, Cindy Neunert, Nichola Cooper, Rachael F Grace

{"title":"Treatment Landscape in Pediatric Immune Thrombocytopenia: Addressing Unmet Needs.","authors":"Joana Azevedo, Jennifer DiRaimo, Cindy Neunert, Nichola Cooper, Rachael F Grace","doi":"10.1002/pbc.31758","DOIUrl":"https://doi.org/10.1002/pbc.31758","url":null,"abstract":"Pediatric immune thrombocytopenia (ITP) is associated with a multifaceted burden on children and their parents/caregivers due to bleeding, fatigue, activity restrictions, and psychological distress. Most children recover within 12 months, but up to 30% develop chronic ITP. While emergent therapies, such as steroids and intravenous immunoglobulin, are effective in many children and transiently raise platelet counts, 38-47% of children require subsequent therapies. The choice of subsequent therapy for individual children with ITP is often complex and the absence of head-to-head comparisons of available therapies and the use of nonstandardized outcomes in randomized clinical trials complicates treatment decisions. Furthermore, medication access varies globally and by age. Additional unmet needs in pediatric ITP include a lack of support and educational resources allowing children and parents/caregivers to effectively participate in treatment decisions, inadequate prediction of treatment response and disease chronicity, heterogeneous approaches to diagnostic evaluation of ITP, scarcity of novel treatments for children unresponsive to current therapies, and the need for a multispecialty approach to support the mental health of children and their families. This review summarizes the known impact of ITP on children and their families, current treatment strategies, and unmet needs in pediatric ITP.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31758"},"PeriodicalIF":2.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

User Perceptions of a Multilevel mHealth Intervention to Boost Adherence to Hydroxyurea in Sickle Cell Disease. 用户感知多层次移动健康干预，以提高对镰状细胞病羟基脲的依从性。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-05 DOI: 10.1002/pbc.31746

Christina M Abrams, Natalia Davila, Sherif M Badawy, Maura M Kepper, Robert W Gibson, Allison A King, Victor R Gordeuk, Chinonyelum Nwosu, Sophi Li, Jeffrey A Glassberg, Lisa M Klesges, Nirmish Shah, Don Brambilla, Jane S Hankins

{"title":"User Perceptions of a Multilevel mHealth Intervention to Boost Adherence to Hydroxyurea in Sickle Cell Disease.","authors":"Christina M Abrams, Natalia Davila, Sherif M Badawy, Maura M Kepper, Robert W Gibson, Allison A King, Victor R Gordeuk, Chinonyelum Nwosu, Sophi Li, Jeffrey A Glassberg, Lisa M Klesges, Nirmish Shah, Don Brambilla, Jane S Hankins","doi":"10.1002/pbc.31746","DOIUrl":"https://doi.org/10.1002/pbc.31746","url":null,"abstract":"Background: Adherence to hydroxyurea has been low historically. The InCharge Health app demonstrates increased adherence with hydroxyurea, but engagement has not been fully investigated. This study investigated the association between InCharge Health app perceptions and app engagement among adolescents and young adults with sickle cell disease (SCD).Methods: We obtained user perceptions of InCharge with the Mobile App Rating Scale (MARS) among participants of the \"Integration of mHealth into Sickle Cell Disease Care to Increase Hydroxyurea Utilization\" study. Days of app use were correlated with reported patient-reported outcomes of interest, ease of use, the utility of features, and importance of features.Results: Of 293 enrolled participants, 284 remained active in the study, and 206 (72.5%) completed the 24-week MARS survey. App Interest was positively correlated with app use (p = 0.01) and self-reported days of app use (p = 0.0008). Perceived ease of use trended toward significance with greater app use (p = 0.06). Most individuals (72.0%, 144/200) agreed the app helped them remember to take hydroxyurea, with trends toward higher days of app use (p = 0.07). Those who used the app more agreed they would continue to use it after the study (p = 0.04). Most individuals (54.3%) reported that reminders to take their hydroxyurea were the most important app feature.Conclusions: In this study, positive perceptions toward the application features influenced app use and intention to continue using the application. Determining features that drive application utilization can have a positive impact when an app, such as the InCharge app, is demonstrated to improve adherence with proven therapy.","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e31746"},"PeriodicalIF":2.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Cervical Clear Cell Adenocarcinoma in an Infant: A Rare Tumor in an Uncommon Site. 婴儿原发性宫颈透明细胞腺癌：罕见部位的罕见肿瘤。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31772

Jianwei Zhang, Longxia Zhou, Huan Du, Lili Zhang, Dali Guo, Huibo An

引用次数: 0

Recurrent Immune-Effector Cell-Associated Neurotoxicity Syndrome with Atypical Manifestations after Tisagenlecleucel. 复发性免疫效应细胞相关神经毒性综合征伴tisagenleclear后非典型表现。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31763

Devin Murphy, Raja B Khan, Soniya N Pinto, Jean-Yves Metais, Stephen Gottschalk, Swati Naik

引用次数: 0

Rare Findings of Spleen Lesions Secondary to Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Children. 儿童嗜血球性淋巴组织细胞增多症继发于爱泼斯坦-巴尔病毒的罕见发现。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31776

Zhengli Shan, Yu Guo, Zhiliang Cheng, Yu Feng, Xuehua Peng

引用次数: 0

Letter to the Editor: Proton Therapy for Locally Advanced Unresectable Ameloblastoma in a Child. 致编辑的信：质子治疗儿童局部晚期不可切除成釉细胞瘤。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31773

Amanda Acevedo, Daniel J Indelicato, Ryan J Brisson, Anderson B Collier, Julie A Bradley, Raymond B Mailhot Vega, Claire Esler, Sophie Wilne, Roi Dagan

引用次数: 0

Comment on: Use of Plerixafor for Short-Term Management of Leukopenia in a Pediatric Patient With WHIM Syndrome. 评论：使用Plerixafor短期治疗患有WHIM综合征的儿科患者白细胞减少症。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31748

Julia T Warren, Christophe Arbet-Engels, Deborah J Steiner, Teresa K Tarrant

引用次数: 0

Twenty Years of the Paediatric Radiation Oncology Society. 儿科放射肿瘤学会二十年。

IF 2.4 3区医学

Pediatric Blood & Cancer Pub Date : 2025-05-04 DOI: 10.1002/pbc.31764

Mark N Gaze, Guillaume Beldjoudi, Christian Carrie, Carolyn Freeman, Daniel J Indelicato, Rolf-Dieter Kortmann, Ingrid Kristensen, Anne Laprie, Yasmin Lassen, Anita Mahajan, Karen J Marcus, Pauline Njoki Njiraini, Jeannette Parkes, Arnold C Paulino, Bilal Mazhar Qureshi, Beatriz García Robles, Klaus Seiersen, Beate Timmermann, Natia Esiashvili

引用次数: 0