Pediatric Blood & Cancer最新文献

{"title":"Lost in the Vaso-Occlusion: A Patient's Abdominal Pain Returns With a Vengeance.","authors":"Dunia Hatabah, Martha E Stewart, Nathan Maassel, James P Stevens, Claudia R Morris, Chris A Rees","doi":"10.1002/1545-5017.70674","DOIUrl":"10.1002/1545-5017.70674","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70674"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Document: A Single-Center Qualitative Study of Survivorship Care Plan Barriers and Opportunities Across Pediatric Oncology Stakeholders.","authors":"Molly S Talman, Emma Fleisher, Megan E Salwei, Debra Friedman, Laurie Novak","doi":"10.1002/1545-5017.70677","DOIUrl":"10.1002/1545-5017.70677","url":null,"abstract":"<p><strong>Background: </strong>Survivorship care plans (SCPs) summarize cancer treatment and guide risk-based follow-up for cancer survivors, yet remain difficult to create, share, and use. Stakeholder perspectives are needed to inform usable approaches.</p><p><strong>Objective: </strong>To characterize how SCPs are created, shared, and used in pediatric oncology and identify stakeholder priorities for improving workflows and SCP design.</p><p><strong>Methods: </strong>We conducted semi-structured interviews with childhood cancer survivors and family members, primary care providers (PCPs), and oncology clinicians at a single academic center. Interviews explored SCP receipt or creation, usefulness, barriers, and communication across care settings. Transcripts were analyzed using inductive thematic analysis, with interpretation informed by a sociotechnical work-system perspective.</p><p><strong>Results: </strong>Twenty-one participants were interviewed: seven survivor/family participants (one survivor, six caregivers), nine PCPs, and five oncology clinicians. Four higher order themes were identified: (i) Survivorship care remained oncology-centered, reflecting relational continuity developed during treatment and uncertainty about shared-care roles. (ii) SCPs were valued but poorly integrated into clinical workflows. (iii) SCP content reflected standardized documentation more than tailored user needs: families needed understandable information, PCPs needed concise action items and role clarity, and oncology clinicians needed detailed treatment and guideline information. (iv) Stakeholders viewed digital and AI-assisted tools as potentially helpful for reducing manual work and improving access, but emphasized accuracy, transparency, and oversight.</p><p><strong>Conclusion: </strong>SCP challenges extend beyond the document to surrounding systems of communication, responsibility, and workflow. Future SCPs should be embedded in clinical processes and designed as role-specific, user-centered tools, with technology supporting rather than replacing clinician judgment and relational continuity.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70677"},"PeriodicalIF":2.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation for Children With Cancer: Global Opportunities and Need for Systems-Aligned Interventions.","authors":"Jessica Sparrow, Fair Berg, Charles Gipson, Carlos Rodriguez-Galindo, Daniel C Moreira","doi":"10.1002/1545-5017.70778","DOIUrl":"https://doi.org/10.1002/1545-5017.70778","url":null,"abstract":"<p><strong>Introduction: </strong>Rehabilitation can improve function and quality of life for children with cancer, yet access remains limited and variable across settings. Understanding how rehabilitation is integrated within pediatric oncology care is important to identify opportunities to strengthen access and quality.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of medical and rehabilitation professionals caring for children with cancer. The survey assessed rehabilitation service availability, referral practices, care coordination, financing, workforce knowledge and training, and monitoring of quality indicators. Findings were organized using the Health Systems Plus framework.</p><p><strong>Results: </strong>Responses from 59 professionals representing 32 countries were analyzed, including 44 (74.6%) from low- and middle-income countries. Rehabilitation availability varied across disciplines, settings, and phases of care. Medical providers reported rarely or never referring patients to rehabilitation during inpatient (28%, n = 7/25), outpatient (36%, n = 9/25), and survivorship care (40%, n = 10/25). Referrals typically relied on provider identification of need (85%, n = 50/59) rather than standardized pathways. Assistive product availability varied, with lower availability of hearing (n = 19/59, 32%) and vision (n = 15/59, 25%) products. Family payment for rehabilitation services and assistive products was frequently reported. Workforce challenges included limited rehabilitation knowledge among medical providers and limited training opportunities for rehabilitation providers. Among rehabilitation respondents, 44% (15/34) reported monitoring functional outcomes. Qualitative findings highlighted barriers related to workforce, awareness, financial, infrastructure, geographic, and referral-system challenges.</p><p><strong>Conclusions: </strong>This survey highlights opportunities to improve access to rehabilitation and assistive products through strengthening referral pathways, workforce capacity, financing, care coordination, and monitoring. These components are interdependent and require coordinated system-level action.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Syncytial Viral Infections Among Hospitalized Youth With Sickle Cell Disease.","authors":"Susan Creary, Abbigail Di-Nardo, Anyssa Young, Elliana Draper, Jason Newland","doi":"10.1002/1545-5017.70780","DOIUrl":"https://doi.org/10.1002/1545-5017.70780","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) imposes substantial risk to all infants, but its impact on youth with SCD (Y-SCD) is underexplored. With newer, highly effective RSV monoclonal antibodies (RSV-mAb), research is needed to inform their use in Y-SCD. This single-center study of Y-SCD aged 0-21 years identified 667 hospitalizations that included RSV testing. Of these, 5% were positive for RSV, and 68% occurred in Y-SCD beyond their first RSV season. Intensive care, positive pressure ventilation, and transfusion were required in 21%, 32%, and 21% of hospitalizations, respectively. Findings indicate that multicenter studies are warranted to determine if RSV-mAbs improve outcomes in Y-SCD.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aminophylline Administration for Treatment of Methotrexate-Induced Neurotoxicity in Pediatric Cancer Patients: A Single-Center Case Series.","authors":"Ryan Guerrettaz, Erin Bodenbach, Lauren Watson, Arica Christensen, Michael J Burke","doi":"10.1002/1545-5017.70772","DOIUrl":"https://doi.org/10.1002/1545-5017.70772","url":null,"abstract":"<p><p>Intrathecal methotrexate (MTX) remains a critical component in multiagent chemotherapy regimens for acute lymphoblastic leukemia (ALL). However, MTX-induced neurotoxicity (MIN) can cause significant morbidity. Aminophylline can be a treatment for MIN, mitigating neurotoxicity, but its use has been restricted to case reports and small patient series. In this report, we present treatment outcomes of seven patients who developed MIN and received aminophylline. The median time-to-improvement after aminophylline was 9 h, and the median time to full resolution of symptoms was 36 h. All patients developed full symptom resolution, advocating aminophylline as treatment of MIN in patients with ALL.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding, Fear, and Acceptance: Caregivers' Experiences of Nutritional Support During Childhood Cancer Treatment.","authors":"Danyelle Apparecida Balsamão Marques, Mariana Dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior","doi":"10.1002/1545-5017.70773","DOIUrl":"https://doi.org/10.1002/1545-5017.70773","url":null,"abstract":"<p><strong>Purpose: </strong>To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support.</p><p><strong>Methods: </strong>This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital. Eight groups were conducted with 44 caregivers, and the seven available transcripts, corresponding to 38 caregivers, were analyzed with computer-assisted lexical analysis, interpreted as themes and illustrated with representative quotes, together with an exploratory affective analysis.</p><p><strong>Results: </strong>The accounts spanned two domains, oral feeding and nutritional support, and six themes: altered oral feeding and food preferences, food hygiene and safety, gastrointestinal symptoms, oral nutritional supplements, nasoenteral tube feeding from fear to acceptance, and weight loss, fear, and coping. Caregivers described food selectivity and a shift toward ultra-processed foods, strict hygiene routines driven by fear of infection, and difficulty accepting supplements and the tube. Families who had used tube feeding described it as essential and reported learning to manage it. Negative emotions predominated in the exploratory affective profile, with sadness and fear the most frequent and trust also prominent.</p><p><strong>Conclusion: </strong>The nutritional experience of caregivers during pediatric cancer treatment was shaped by fear and by a gradual acceptance of nutritional support. Supportive care should address caregivers' fears early and help families move to acceptance of oral supplements and tube feeding.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70773"},"PeriodicalIF":2.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive, School-Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review.","authors":"Mary Ann Etling, Hakim Tokhi, Alexander A Boucher","doi":"10.1002/1545-5017.70776","DOIUrl":"https://doi.org/10.1002/1545-5017.70776","url":null,"abstract":"<p><p>The medical burdens of sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement. This scoping review explores the extent to which published research has explored the effects of SCD and TDT on educational success. The review synthesizes their effects on neurocognitive and academic performance alongside health literacy and any interventions that have been studied to mitigate their effects. In addition, the data offer insights into psychosocial impacts and health-related quality of life (HRQOL) for the two diseases, given that these factors can affect academic performance. For SCD in particular, neurocognitive deficits are evident compared to those without SCD, even without silent strokes, and their social and HRQOL are significantly impacted. Fewer data are available for TDT from an academic performance standpoint, but negative HRQOL effects are notable. This research is less commonly reported compared to traditional medical outcomes; however, because most medical outcomes are interwoven with social determinants of health, academic functioning cannot be ignored. After analyzing the data on school and HRQOL outcomes in SCD and TDT, the negative impacts on neurocognitive and psychosocial functions are significant, but data gaps demonstrate that more research toward evidence-based interventions must be undertaken.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70776"},"PeriodicalIF":2.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Adverse Events During Anti-GD2 Immunotherapy Following T- and B-Cell Depleted Haploidentical Transplantation in High-Risk Neuroblastoma: A Pediatric Case Report.","authors":"Guanmei Zhang, Lihua Yu, Danna Lin, Lichan Liang, Chaoke Bu, Yuelin He, Lihua Yang","doi":"10.1002/1545-5017.70495","DOIUrl":"https://doi.org/10.1002/1545-5017.70495","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70495"},"PeriodicalIF":2.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-Omics Reveals a Cryptic RNF213::SLC26A11 Fusion and Targeted Therapy Dynamics in a Patient With Refractory Leukemia.","authors":"Jinlei Yin, Jia Fan, Wei Lin, Yuanyuan Zhang, Ying Wu, Peijing Qi, Mingying Zhang, Zhigang Li, Ruidong Zhang","doi":"10.1002/1545-5017.70777","DOIUrl":"https://doi.org/10.1002/1545-5017.70777","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70777"},"PeriodicalIF":2.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-Sorted EBV PCR Identifies Lineage Shift and Guides Management After Hematopoietic Cell Transplantation for Pediatric EBV-Positive T/NK-Cell Lymphoid Neoplasia: A Case Series.","authors":"Ana M Quintero, Monica Bhatia, Diane George, Pawel Muranski, Prakash Satwani","doi":"10.1002/1545-5017.70770","DOIUrl":"https://doi.org/10.1002/1545-5017.70770","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV)-positive T/natural killer (NK)-cell lymphoid neoplasms, including chronic active EBV disease and EBV-positive T/NK-cell leukemias and lymphomas, are rare, aggressive disorders for which allogeneic hematopoietic cell transplantation (alloHCT) is the only established curative therapy. After alloHCT, plasma or whole-blood EBV polymerase chain reaction (PCR) cannot distinguish relapse from EBV-driven donor B-cell proliferation. Cell-sorted EBV PCR resolves this ambiguity by quantifying EBV DNA across lymphocyte subsets to identify the cell lineage with the highest viral burden. We report four children in whom cell-sorted EBV PCR demonstrated a post-transplant shift in predominant EBV burden from T/NK cells to B cells, enabling de-escalation from cytotoxic therapy to immunosuppression reduction and B-cell-directed treatment.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":" ","pages":"e70770"},"PeriodicalIF":2.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}