Comparing Absolute Neutrophil Counts of Children With Sickle Cell Disease With and Without the Duffy Null Phenotype.

IF 2.4 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-05-19 DOI:10.1002/pbc.31794

Nate Goldfarb, Joseph Stanek, Joseph Walden, Melissa J Rose, Kathleen Nicol, Anthony Villella, Jennifer Young, Susan Creary

引用次数: 0

Abstract

While nonpathogenic, the Duffy null phenotype (DN) lowers circulating neutrophils. DN is common among youth with sickle cell disease (SCD), but its implications on absolute neutrophil counts (ANC) and hydroxyurea over time are unclear. Our retrospective review found that all children who were not receiving hydroxyurea had stable ANC through age 9 years, but those with DN had lower mean ANC starting at 6 years of age. Among hydroxyurea users, ANC increased over time, regardless of DN status, suggesting opportunities to optimize hydroxyurea. Future studies of hospitalized and older individuals are needed to further examine DN's impact on people with SCD.

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有无Duffy零表型儿童镰状细胞病绝对中性粒细胞计数的比较

虽然无致病性，但Duffy null表型（DN）降低了循环中性粒细胞。DN在青年镰状细胞病（SCD）中很常见，但其对绝对中性粒细胞计数（ANC）和羟基脲随时间的影响尚不清楚。我们的回顾性研究发现，所有未接受羟脲治疗的儿童在9岁时ANC稳定，但患有DN的儿童在6岁时ANC的平均值较低。在羟基脲使用者中，ANC随着时间的推移而增加，与DN状态无关，这表明有机会优化羟基脲。未来需要对住院患者和老年人进行研究，以进一步检查DN对SCD患者的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.