Pathology International最新文献_第4页

Glioneuronal and neuronal tumors: A perspective. 神经胶质细胞瘤和神经元肿瘤：透视。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1111/pin.13478

Takashi Komori

引用次数: 0

Regarding to low-grade carcinoma with acinic cell carcinoma-like features of the parotid gland with CRTC3::IQGAP1 fusion. 腮腺低分化癌伴有尖细胞癌样特征，CRTC3::IQGAP1融合。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1111/pin.13485

Ebtissam Alerraqi

引用次数: 0

Rare finding of mucorales sporangia and chlamydospores in tissue. 在组织中发现罕见的粘孢子菌孢子囊和衣孢子。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1111/pin.13476

Misa Kojima, Masatomo Kimura, Kazuhiko Kuwahara, Hisatomo Tamaki, Ryuji Yasumatsu, Sota Sadamoto, Takayuki Shinohara, Kazuki Amemiya, Yoshitsugu Miyazaki, Akihiko Ito

引用次数: 0

Colitis with subepithelial hyaline fibrosis associated with nintedanib therapy for fibrosing interstitial lung disease: A drug-related collagenous colitis? 与宁替尼治疗纤维化间质性肺病相关的上皮下透明纤维化结肠炎：与药物相关的胶原性结肠炎？

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI: 10.1111/pin.13484

Mutsuki Makino, Kenji Kawaguchi

引用次数: 0

Detection of Legionella species other than Legionella pneumophila in formalin-fixed paraffin-embedded tissue: An autopsy case study. 在福尔马林固定的石蜡包埋组织中检测嗜肺军团菌以外的军团菌：尸检病例研究。

IF 4.6 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-16 DOI: 10.1111/pin.13480

Miho Riku, Ritsuko Nakamura, Tsuguaki Terashima, Daisuke Sakanashi, Sosuke Nakata, Makoto Kawamura, Koji Ohnishi, Hideaki Ito, Eizo Watanabe, Hiroshige Mikamo, Kenji Kasai

{"title":"Detection of Legionella species other than Legionella pneumophila in formalin-fixed paraffin-embedded tissue: An autopsy case study.","authors":"Miho Riku, Ritsuko Nakamura, Tsuguaki Terashima, Daisuke Sakanashi, Sosuke Nakata, Makoto Kawamura, Koji Ohnishi, Hideaki Ito, Eizo Watanabe, Hiroshige Mikamo, Kenji Kasai","doi":"10.1111/pin.13480","DOIUrl":"10.1111/pin.13480","url":null,"abstract":"Diagnosing the cause of death can be challenging, particularly for patients with no prior history of visits to the treating hospital. We encountered a case involving a 76-year-old male who was discovered in a state of cardiopulmonary arrest at his home and subsequently declared deceased in our hospital due to severe pneumonia. He had exhibited symptoms of fever over 37°C and severe coughing for several days. Despite consulting a primary care physician one day prior, his symptoms worsened. Autopsy findings revealed an increase in lung weight and diffuse changes in parenchyma. Histological analysis showed numerous inflammatory cells and exudate within the alveoli. Gram and Periodic acid-Schiff staining were negative, but slight staining was observed in the cytoplasm of macrophages by Warthin-starry and Gimenez stains. Tests using a pan bacterial/viral detection kit and qualitative polymerase chain reaction (PCR) for Legionella pneumophila were negative. However, using deoxyribonucleic acid extracted from formalin-fixed paraffin-embedded lung tissue, PCR amplification of the ssrA gene of congeneric Legionella species yielded positive results. The results suggest that the cause of death was likely due to bacterial pneumonia caused by Legionella species.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"655-659"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult T-cell leukemia/lymphoma with angioimmunoblastic T-cell lymphoma-like feature and molecularly confirmed RHOA Gly 17 Val (G17V) mutation: A case report. 成人T细胞白血病/淋巴瘤，具有血管免疫母细胞性T细胞淋巴瘤样特征和分子证实的RHOA Gly 17 Val (G17V)突变：病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-08-30 DOI: 10.1111/pin.13477

Rika Maruyama, Yuzo Oyama, Kentaro Nagamatsu, Keiji Ono, Morishige Takeshita, Tsutomu Daa

{"title":"Adult T-cell leukemia/lymphoma with angioimmunoblastic T-cell lymphoma-like feature and molecularly confirmed RHOA Gly 17 Val (G17V) mutation: A case report.","authors":"Rika Maruyama, Yuzo Oyama, Kentaro Nagamatsu, Keiji Ono, Morishige Takeshita, Tsutomu Daa","doi":"10.1111/pin.13477","DOIUrl":"10.1111/pin.13477","url":null,"abstract":"We report a case of adult T-cell leukemia/lymphoma (ATLL) with angioimmunoblastic T-cell lymphoma (AITL/nTFHL-AI)-like feature. An 88-year-old Japanese woman with seropositive for the Human T-lymphotropic virus type 1 (HTLV-1) was incidentally diagnosed with generalized lymphadenopathy. Biopsy of the cervical lymph node demonstrated the proliferation of small- or medium-sized and large atypical lymphocytes associated with eosinophils, high endothelial venules, and clear cells. Immunohistochemical analysis revealed atypical lymphocytes were CD3- and CD4-positive. Atypical T cells bore the T-follicular helper phenotype (PD1, ICOS, and BCL6) and were positive for CD25 and chemokine receptor 4. Epstein-Barr virus encoded RNA-positive cells were scattered in the background via in situ hybridization. The histological findings were similar to those of AITL/nTFHL-AI; however, the immunohistochemical results did not exclude the possibility of ATLL. Southern blot analysis detected integration of HTLV-1 proviral DNA. The RHOA Gly 17 Val (G17V) mutation was detected by the peptide nucleic acid-locked nucleic acid clamp method. Finally, the patient was diagnosed with ATLL with AITL-like feature and exhibited a similar morphology, immunophenotype, and mutational signature to AITL/nTFHL-AI. ATLL mimics other types of T-cell lymphomas. Thus, in HTLV-1 endemic areas, routine screening for HTLV-1 serology is necessary to avoid misdiagnosis of other lymphoid malignancies.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"641-647"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New clinicopathological concept of endometrial carcinoma with integration of histological features and molecular profiles. 结合组织学特征和分子特征的子宫内膜癌临床病理新概念。

IF 2.5 4区医学

Pathology International Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.1111/pin.13471

Masanori Yasuda

{"title":"New clinicopathological concept of endometrial carcinoma with integration of histological features and molecular profiles.","authors":"Masanori Yasuda","doi":"10.1111/pin.13471","DOIUrl":"10.1111/pin.13471","url":null,"abstract":"The dual-stratified pathway of endometrial carcinomas (ECs) has long been dominant. However, in 2013, The Cancer Genome Atlas (TCGA) defined four EC subgroups with distinctive prognoses. Inspired by TCGA, in 2018, the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) provided four pragmatic molecular classifiers to apply surrogate immunohistochemical markers to TCGA subgroup categorization. These trends prompted the revision of 2020 WHO Classification of Female Genital Tumors, 5th edition (2020 WHO classification), in which four molecular subtypes are recognized: POLE-ultramutated; mismatch repair-deficient; p53-mutant; and no specific molecular profile. In the 2020 WHO classification, the diagnostic algorithm is characterized by prioritizing POLEmut over other molecular abnormalities. Following the 2020 WHO classification, Federation of International Gynecology and Obstetrics (FIGO) proposed a new staging system in 2023. The updated system focuses on diagnostic parameters, such as histological type and grade, lymphovascular space invasion, and molecular alterations. These new histomolecular diagnostic concepts of ECs are being accordingly introduced into the routine pathology practice. For the first time, the 2020 WHO classification includes mesonephric-like adenocarcinoma (MLA) as a novel histological entity, mimicking the conventional mesonephric adenocarcinoma, but is considered of Müllerian ductal origin.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"557-573"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between histopathological growth patterns with tumor budding and poorly differentiated clusters in colorectal liver metastasis treated with preoperative systemic therapy. 接受术前系统治疗的结直肠肝转移瘤的组织病理学生长模式与肿瘤萌芽和分化不良簇之间的关联。

IF 2.5 4区医学

Pathology International Pub Date : 2024-10-01 Epub Date: 2024-08-26 DOI: 10.1111/pin.13473

Thiyaphat Laohawetwanit, Sompon Apornvirat, Charinee Kantasiripitak

{"title":"The association between histopathological growth patterns with tumor budding and poorly differentiated clusters in colorectal liver metastasis treated with preoperative systemic therapy.","authors":"Thiyaphat Laohawetwanit, Sompon Apornvirat, Charinee Kantasiripitak","doi":"10.1111/pin.13473","DOIUrl":"10.1111/pin.13473","url":null,"abstract":"The liver's unique cellular structure makes it a frequent site for metastatic cancer. In colorectal liver metastasis (CRLM), surgical resection is essential for long-term survival. Histopathological growth patterns (HGPs) in CRLM, including desmoplastic and nondesmoplastic patterns, provide critical prognostic information. Tumor budding (TB) and poorly differentiated clusters (PDCs), indicators of aggressive cancer behavior, are evaluated using standardized histological scoring systems and are linked to epithelial-mesenchymal transition. This study explored the correlation between HGPs, TB, and PDCs in CRLM. Archived data from Thammasat University Hospital, including resected CRLM specimens, were analyzed. This study evaluated 51 CRLM resection specimens treated with preoperative systemic therapy, finding most to be nondesmoplastic with low TB and grade 1 PDC. Desmoplastic growth was significantly more prevalent in cases receiving preoperative chemotherapy than those that did not. Higher 3-year mortality was noted in nondesmoplastic groups and those with higher TB and tumor regression grade (TRG) scores. Significant correlations were observed between HGPs, TB, and PDCs, despite challenges in assessing these parameters due to issues with noncancer cells, extracellular mucin, bile ductular proliferation, and retraction artifacts. This study underscores the prognostic significance of HGPs, TB, PDCs, and TRG scores in CRLM, highlighting the need for precise histopathological evaluation for more accurate prognostic implications.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"583-591"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast cancer during pregnancy of Luminal A type overexpressed CXCL13. 妊娠期 A 型乳腺癌过表达 CXCL13。

IF 2.5 4区医学

Pathology International Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI: 10.1111/pin.13474

Fumi Nozaki, Yoko Nakanishi, Tomoyuki Tanino, Tomohiro Ochi, Reika In, Yuka Kajiura, Kumiko Kida, Junko Takei, Atsushi Yoshida, Naoki Kanomata, Atsuko Kitano, Hideko Yamauchi, Shinobu Masuda

{"title":"Breast cancer during pregnancy of Luminal A type overexpressed CXCL13.","authors":"Fumi Nozaki, Yoko Nakanishi, Tomoyuki Tanino, Tomohiro Ochi, Reika In, Yuka Kajiura, Kumiko Kida, Junko Takei, Atsushi Yoshida, Naoki Kanomata, Atsuko Kitano, Hideko Yamauchi, Shinobu Masuda","doi":"10.1111/pin.13474","DOIUrl":"10.1111/pin.13474","url":null,"abstract":"Pregnancy-associated breast cancer has been increasing. In this study, we analyzed patients with breast cancer that occurred during pregnancy (PrBC) and compared their genetic profiles with those of patients with breast cancer that did not occur during pregnancy, within 1 year after childbirth nor during lactation (non-PrBC). We performed gene expression analyses of patients with PrBC and non-PrBC using microarrays and qRT-PCR. Microarray analysis showed that 355 genes were upregulated in the luminal-type PrBC group compared to those in the non-PrBC group. The C-X-C motif chemokine ligand 13 (CXCL13) gene was the most upregulated in the PrBC group compared to that in the non-PrBC group, especially in the luminal A-type (p = 0.016). This result was corroborated by the qRT-PCR analysis of microdissected cancer cells (p < 0.001). A negative correlation was observed between CXCL13 and estrogen receptor 1 (ESR1) mRNA expression levels in luminal A-type breast carcinoma (p < 0.001). Our results provide clues for a better understanding of breast cancer pathogenesis during pregnancy.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"592-603"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence in situ hybridization-negative intra-articular myxoid liposarcoma with complex rearrangements involving EWSR1::DDIT3 detected using nanopore sequencing. 利用纳米孔测序法检测到荧光原位杂交阴性的关节内肌样脂肪肉瘤，其中有涉及 EWSR1::DDIT3 的复杂重排。

IF 2.5 4区医学

Pathology International Pub Date : 2024-10-01 Epub Date: 2024-07-29 DOI: 10.1111/pin.13468

Naohiro Makise, Jason Lin, Hajime Kageyama, Naoki Takeda, Mariko Oikawa, Takahiro Sugiyama, Hidetada Kawana, Akinobu Araki, Hideyuki Kinoshita, Hiroto Kamoda, Yoko Hagiwara, Akihiko Yoshida, Tsukasa Yonemoto, Masahito Kawazu, Makiko Itami

{"title":"Fluorescence in situ hybridization-negative intra-articular myxoid liposarcoma with complex rearrangements involving EWSR1::DDIT3 detected using nanopore sequencing.","authors":"Naohiro Makise, Jason Lin, Hajime Kageyama, Naoki Takeda, Mariko Oikawa, Takahiro Sugiyama, Hidetada Kawana, Akinobu Araki, Hideyuki Kinoshita, Hiroto Kamoda, Yoko Hagiwara, Akihiko Yoshida, Tsukasa Yonemoto, Masahito Kawazu, Makiko Itami","doi":"10.1111/pin.13468","DOIUrl":"10.1111/pin.13468","url":null,"abstract":"Myxoid liposarcoma (MLPS) is a rare sarcoma, typically arising in deep soft tissues during the fourth to fifth decades of life. Histologically, MLPS is composed of uniform oval cells within a background of myxoid stroma and chicken-wire capillaries. Genetically, MLPS is characterized by the FUS/EWSR1::DDIT3 fusion gene, which generally results from balanced interchromosomal translocation and is detectable via DDIT3 break-apart fluorescence in situ hybridization (FISH). Here, we report an unusual intra-articular MLPS case, negative for DDIT3 break-apart FISH but positive for EWSR1::DDIT3. An 18-year-old female was referred to our hospital complaining of an intra-articular mass in the right knee joint. Histologically, the tumor was mainly composed of mature adipocytes, brown fat-like cells, and lipoblasts. Nanopore sequencing detected DNA rearrangements between EWSR1 and DDIT3 and clustered complex rearrangements involving multiple chromosomes, suggesting chromoplexy. Methylation classification using random forest, t-distributed stochastic neighbor embedding, and unsupervised hierarchical clustering correctly classified the tumor as MLPS. The copy number was almost flat. The TERT promoter C-124T was also detected. This report highlights, for the first time, the potential value of a fast and low-cost nanopore sequencer for diagnosing sarcomas.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"604-610"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0