Pathology International最新文献_第4页

Resurgence of morphology: Discarded small cell lung carcinoma subtypes reflect current molecular classification. 形态学的复苏：被废弃的小细胞肺癌亚型反映了当前的分子分类。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1111/pin.13460

Hironori Ninomiya

引用次数: 0

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer. 毛细血管的特殊形状与浸润性乳腺癌患者的不良预后有关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1111/pin.13442

Hnin-Wint-Wint Swe, Masayoshi Fujisawa, Toshiaki Ohara, Yu Komatsubara, Teizo Yoshimura, Tadahiko Shien, Akihiro Matsukawa

{"title":"The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.","authors":"Hnin-Wint-Wint Swe, Masayoshi Fujisawa, Toshiaki Ohara, Yu Komatsubara, Teizo Yoshimura, Tadahiko Shien, Akihiro Matsukawa","doi":"10.1111/pin.13442","DOIUrl":"10.1111/pin.13442","url":null,"abstract":"Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer. Four hundred and eleven primary breast cancer specimens were collected, and the sections were immunohistochemically stained with CD31 (single staining) and CD31 and Collagen IV (double staining). The prognosis of patients was examined based on the MVD value, and the presence of GMP and other blood vessels with other specific shapes. As a result, high MVD value and the presence of GMP were not associated with worse prognosis. By contrast, patients with deep-curved capillaries surrounding tumor cell nests (C-shaped) or excessively branched capillaries near tumor cell nests showed a significantly poor prognosis. The presence of these capillaries was also correlated with clinicopathological parameters such as Ki-67 index. Thus, the morphology of capillaries rather than MVD can be a better indicator of tumor aggressiveness.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into cancer pathology learned from the dynamics of cancer-associated fibroblasts. 从癌症相关成纤维细胞的动态中了解癌症病理学的新见解。

IF 2.5 4区医学

Pathology International Pub Date : 2024-06-25 DOI: 10.1111/pin.13461

Genichiro Ishii

{"title":"New insights into cancer pathology learned from the dynamics of cancer-associated fibroblasts.","authors":"Genichiro Ishii","doi":"10.1111/pin.13461","DOIUrl":"https://doi.org/10.1111/pin.13461","url":null,"abstract":"Paget's \"Seed and Soil\" theory, proposed in 1889, emphasizes the importance of the microenvironment where cancer cells grow in metastatic sites. Over a century later, this concept remains a cornerstone in comprehending cancer biology and devising treatment strategies. The \"Seed and Soil\" theory, which initially explained how cancer spreads to distant organs, now also applies to the tumor microenvironment (TME) within primary tumors. This theory emphasizes the critical interaction between cancer cells (\"seeds\") and their surrounding environment (\"soil\") and how this interaction affects both tumor progression within the primary site and at metastatic sites. An important point to note is that the characteristics of the TME are not static but dynamic, undergoing substantial changes during tumor progression and after treatment with therapeutic drugs. Cancer-associated fibroblasts (CAFs), recognized as the principal noncancerous cellular component within the TME, play multifaceted roles in tumor progression including promoting angiogenesis, remodeling the extracellular matrix, and regulating immune responses. In this comprehensive review, we focus on the findings regarding how the dynamics of CAFs contribute to cancer progression and drug sensitivity. Understanding the dynamics of CAFs could provide new insights into cancer pathology and lead to important advancements in cancer research and treatment.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141458533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the usefulness of a bile duct biopsy and bile cytology using a hyperspectral camera and machine learning. 利用高光谱照相机和机器学习研究胆管活检和胆汁细胞学检查的实用性。

IF 2.5 4区医学

Pathology International Pub Date : 2024-06-01 Epub Date: 2024-05-24 DOI: 10.1111/pin.13438

Tomoko Norose, Nobuyuki Ohike, Daiki Nakaya, Kentaro Kamiya, Yoshiya Sugiura, Misato Takatsuki, Hirotaka Koizumi, Chie Okawa, Aya Ohya, Miyu Sasaki, Ruka Aoki, Kazunari Nakahara, Shinjiro Kobayashi, Keisuke Tateishi, Junki Koike

引用次数: 0

Regulatory T-cells activated in metastatic draining lymph nodes possibly suppress cancer immunity in cancer tissues of head and neck squamous cell cancer. 转移引流淋巴结中激活的调节性 T 细胞可能会抑制头颈部鳞状细胞癌癌组织中的癌症免疫。

IF 2.5 4区医学

Pathology International Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1111/pin.13430

Susumu Suzuki, Toyonori Tsuzuki, Masato Saito, Toshihiko Ishii, Taishi Takahara, Akira Satou, Daisuke Inukai, Shunpei Yamanaka, Kazuhiro Yoshikawa, Ryuzo Ueda, Tetsuya Ogawa

{"title":"Regulatory T-cells activated in metastatic draining lymph nodes possibly suppress cancer immunity in cancer tissues of head and neck squamous cell cancer.","authors":"Susumu Suzuki, Toyonori Tsuzuki, Masato Saito, Toshihiko Ishii, Taishi Takahara, Akira Satou, Daisuke Inukai, Shunpei Yamanaka, Kazuhiro Yoshikawa, Ryuzo Ueda, Tetsuya Ogawa","doi":"10.1111/pin.13430","DOIUrl":"10.1111/pin.13430","url":null,"abstract":"Regulatory T cells (Tregs) play an important role in creating an immunosuppressive microenvironment in cancer tissues. However, the mechanisms by which Tregs are activated and suppress cancer immunity remain unclear. To elucidate these mechanisms, we performed a T cell receptor (TCR) repertoire analysis of Tregs and conventional T cells in peripheral blood, draining lymph nodes (DLNs), and cancer tissues of patients with head and neck squamous cell cancer (HNSCC). We found that the TCR repertoire was skewed in cancer tissue and metastatic DLNs (M-DLNs) compared with non-metastatic DLNs, and TCR repertoire similarities in Tregs and CD8+ T cells between M-DLNs and cancer tissue were high compared with those at other sites. These results suggest that Tregs and CD8+ T cells are activated in M-DLNs and cancer tissues by cancer antigens, such as neoantigens, and shared antigens and Tregs suppress CD8+ T cell function in a cancer antigen-specific manner in M-DLNs and cancer tissue. Moreover, M-DLNs might be a source of Tregs and CD8+ T cells recruited into the cancer tissue. Therefore, targeting Tregs in M-DLNs in an antigen-specific manner is expected to be a novel immunotherapeutic strategy for HNSCCs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of bronchiolar adenoma with their diagnostic difficulties and important clues 两例支气管腺瘤及其诊断困难和重要线索

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-02 DOI: 10.1111/pin.13436

Shinsuke Aida, Yuichi Ishikawa, Mayumi Kaneko

引用次数: 0

Letter to the Editor regarding “Mixed epithelial and stromal tumor synchronously detected in bilateral kidneys with end‐stage renal failure” 致编辑的信，内容涉及 "在终末期肾衰竭的双侧肾脏中同步发现上皮和间质混合瘤"。

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-02 DOI: 10.1111/pin.13434

Begum Calim‐Gurbuz, Tuce Soylemez‐Akkurt, Basak Bekiroglu, Merve Sam Ozdemir, Mehmet Sahin

引用次数: 0

Multi-UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis. 甲状腺病变中的多单灶性（MUF）与多灶性相反：与淋巴细胞性甲状腺炎的关系

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-01 Epub Date: 2024-04-01 DOI: 10.1111/pin.13421

Mehtap Derya Aydemirli, Hans Morreau

{"title":"Multi-UniFocality (MUF), in contrast to multifocality, in thyroid lesions: Relation to lymphocytic thyroiditis.","authors":"Mehtap Derya Aydemirli, Hans Morreau","doi":"10.1111/pin.13421","DOIUrl":"10.1111/pin.13421","url":null,"abstract":"Whereas multifocality typically concerns papillary thyroid carcinoma (PTC) without specification of intrathyroidal metastatic or independent nature of tumor foci, the designation of the latter as Multi-UniFocal (MUF) may be relevant for select cases. A case series involving multifocal thyroid lesions with divergent histopathological morphology and/or molecular profile, with molecular evaluation of multiple individual tumor foci per patient based on a next-generation sequencing approach, was retrospectively reviewed. Twenty-five patient cases with multifocal thyroid lesions suggestive of MUF, with 2-6 (median 3) tumor foci per patient, were described. Tumor lesions comprised diverse histopathology, including PTC, (E)FVPTC, NIFTP, FA, FTC, and oncocytic. Morphologically similar and/or diverse tumor foci harbored different molecular alterations (suggestive of non-shared clonality); with(out) coexistent similar foci harboring identical molecular alterations; or (partly) shared molecular alterations. MUF was associated with chronic lymphocytic thyroiditis in almost half of the cases. The recognition of MUF may justify the independent clinical consideration per individual tumor focus; as separate lesions albeit within a multifocal context. The potential clinical relevance and prognostic value of MUF remain to be further established.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem-immunoreceptor tyrosine-based activation motif. 糖蛋白非转移性黑色素瘤蛋白 B 通过其基于血液免疫受体酪氨酸的激活基团影响膀胱癌细胞的恶性潜能。

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-01 Epub Date: 2024-03-19 DOI: 10.1111/pin.13419

Tomokazu Kimura, Yukari Okita, Yoshiyuki Nagumo, Jas Min Chin, Muhammad Ali Fikry, Masanobu Shiga, Shuya Kandori, Takashi Kawahara, Hiroyuki Suzuki, Hiroyuki Nishiyama, Mitsuyasu Kato

{"title":"Glycoprotein nonmetastatic melanoma protein B impacts the malignant potential of bladder cancer cells through its hem-immunoreceptor tyrosine-based activation motif.","authors":"Tomokazu Kimura, Yukari Okita, Yoshiyuki Nagumo, Jas Min Chin, Muhammad Ali Fikry, Masanobu Shiga, Shuya Kandori, Takashi Kawahara, Hiroyuki Suzuki, Hiroyuki Nishiyama, Mitsuyasu Kato","doi":"10.1111/pin.13419","DOIUrl":"10.1111/pin.13419","url":null,"abstract":"Bladder cancer is one of the most common cancers among men worldwide. Although multiple genomic mutations and epigenetic alterations have been identified, an efficacious molecularly targeted therapy has yet to be established. Therefore, a novel approach is anticipated. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane glycoprotein that is highly expressed in various cancers. In this study, we evaluated bladder cancer patient samples and found that GPNMB protein abundance is associated with high-grade tumors, and both univariate and multivariate analyses showed that GPNMB is a prognostic factor. Furthermore, the prognosis of patients with high GPNMB levels was significantly poorer in those with nonmuscle invasive bladder cancer (NMIBC) than in those with muscle invasive bladder cancer (MIBC). We then demonstrated that knockdown of GPNMB in MIBC cell lines with high GPNMB inhibits cellular migration and invasion, whereas overexpression of GPNMB further enhances cellular migration and invasion in MIBC cell lines with originally low GPNMB. Therefore, we propose that GPNMB is one of multiple driver molecules in the acquisition of cellular migratory and invasive potential in bladder cancers. Moreover, we revealed that the tyrosine residue in the hemi-immunoreceptor tyrosine-based activation motif (hemITAM) is required for GPNMB-induced cellular motility.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphic lymphoproliferative disorder arising in a rheumatoid arthritis patient, presenting as fibrin-associated large B-cell lymphoma-like lesions in aortic and mitral valves. 一名类风湿性关节炎患者出现多形性淋巴组织增生性疾病，表现为主动脉瓣和二尖瓣的纤维蛋白相关大 B 细胞淋巴瘤样病变。

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-01 Epub Date: 2024-04-02 DOI: 10.1111/pin.13424

Hideaki Tsujii, Ryuko Nakayama, Sohei Funakoshi, Shuhei Tsuji, Hironori Haga, Kazuo Ono

引用次数: 0