Pathology International最新文献_第5页

Autopsy Case of Severe Right Heart Failure Accompanied by Pulmonary Arterial Hypertension With Suspected Osler's Disease. 严重右心衰伴肺动脉高压疑似奥斯勒氏病尸检1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-06-01 Epub Date: 2025-04-23 DOI: 10.1111/pin.70017

Moe Matsumoto, So Osato, Chiemi Oishi, Komei Mizokami, Kazuya Hosokawa, Keimei Yoshida, Kotaro Abe, Yoshinao Oda, Shinichi Aishima

引用次数: 0

Proposal for a New Classification of Rare Cancers Adopting Updated Histological Tumor Types. 采用最新组织学肿瘤类型的罕见癌症新分类的建议。

IF 2.5 4区医学

Pathology International Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1111/pin.70021

Ryoko Rikitake, Yasushi Yatabe, Yoko Yamamoto, Tatsunori Shimoi, Shintaro Iwata, Yasushi Goto, Yu Mizushima, Akira Kawai, Takahiro Higashi

{"title":"Proposal for a New Classification of Rare Cancers Adopting Updated Histological Tumor Types.","authors":"Ryoko Rikitake, Yasushi Yatabe, Yoko Yamamoto, Tatsunori Shimoi, Shintaro Iwata, Yasushi Goto, Yu Mizushima, Akira Kawai, Takahiro Higashi","doi":"10.1111/pin.70021","DOIUrl":"10.1111/pin.70021","url":null,"abstract":"Several classifications have been proposed to define rare cancers; however, the pathophysiological understanding of tumors evolves rapidly. We propose a New Classification of Rare Cancer (NCRC) using the updated International Classification of Diseases for Oncology 3.2 coding system and World Health Organization Classification of Tumors 5th edition. We applied patient data recorded in the National Cancer Registry of Japan to the new classification, setting a cut-off of a crude incidence rate of 6 cases/100 000/year to define rare cancers, and developed a list of rare cancers in Japan from 2016 to 2019. The NCRC system identified various rare cancers, comprising 20.0% of all cancer diagnoses in this period. To examine this classification system's performance, we compared rare/non-rare labeling of cancers by the Surveillance of Rare Cancers in Europe (RARECARENet) project and NCRC system. Compared with cases using the RARECARENet classification in Europe, 69 351 cases/year (6.8%) switched status with our classification, with 45 293 and 232 109 cases (4 years) switching from rare and non-rare, respectively. Major differences included diffuse large B-cell lymphomas, some thyroid cancers, oral cavity and lip cancers, and squamous cell carcinoma of the uterine cervix. As the NCRC includes newly classified tumor entities, it warrants validation using other diverse cohorts.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"291-309"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cmtm4 Deficiency Inhibits Helicobacter pylori-Induced Gastric Carcinogenesis. Cmtm4缺乏抑制幽门螺杆菌诱导的胃癌发生。

IF 2.5 4区医学

Pathology International Pub Date : 2025-06-01 Epub Date: 2025-05-27 DOI: 10.1111/pin.70020

Yanfei Lang, Xiurui Han, Xin Liu, Jing Ning, Xinyu Hao, Hejun Zhang, Jing Zhang, Kangle Zhai, Jing Zhang, Weiwei Fu, Shigang Ding

{"title":"Cmtm4 Deficiency Inhibits Helicobacter pylori-Induced Gastric Carcinogenesis.","authors":"Yanfei Lang, Xiurui Han, Xin Liu, Jing Ning, Xinyu Hao, Hejun Zhang, Jing Zhang, Kangle Zhai, Jing Zhang, Weiwei Fu, Shigang Ding","doi":"10.1111/pin.70020","DOIUrl":"10.1111/pin.70020","url":null,"abstract":"Helicobacter pylori is the main pathogenic factor in gastric cancer (GC), and the interleukin (IL)-17-mediated inflammatory response plays a crucial role in both H. pylori infection and gastric carcinogenesis. CMTM4, a subunit of the IL-17 receptor (IL-17R), has been implicated in immune responses, but its role in GC development remains unclear. In this study, we investigate the role of CMTM4 during H. pylori-induced gastric carcinogenesis using Cmtm4 knockout (KO) mice. Our findings indicated that Cmtm4 deficiency inhibited GC development and pseudopyloric metaplasia, while reducing DNA damage in the gastric mucosa. Mechanistically, Cmtm4 deletion downregulated the IL-17 signaling pathway in GC. Specifically, it suppressed the expression of IL-17 receptor RC (IL-17RC) and its downstream signaling molecules, resulting in the inhibition of nuclear factor-κ B (NF-κB) activation and a decrease in NADPH oxidase-1 (NOX1) levels. These results suggest that Cmtm4 deletion suppresses H. pylori-induced gastric carcinogenesis and precancerous lesion formation, potentially through the regulation of IL-17RC/NF-κB/NOX1 signaling, which may represent a new target for the early prevention of GC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"278-290"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pigmented Carcinoid in the Rectum. 直肠色素样癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-06-01 Epub Date: 2025-04-15 DOI: 10.1111/pin.70013

Takushi Hara, Kotaro Shibagaki, Mamiko Nagase, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba, Naoki Oshima, Norihisa Ishimura, Asuka Araki, Daisuke Niino, Shunji Ishihara

引用次数: 0

High-Grade Serous Carcinoma With Focal Mesonephric-Like Morphology and Subclonal p53 Abnormal Expression: A Potential Diagnostic Pitfall. 高级别浆液性癌伴局灶性中肾样形态和亚克隆p53异常表达：一个潜在的诊断缺陷。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1111/pin.70011

Zitong Zhao, Timothy Kwang Yong Tay, Tony Kiat Hon Lim, Liang Seah Tay, Gek San Tan, Wui Seng Khoo, Shing Lih Wong

引用次数: 0

The Role of Artificial Intelligence in the Evaluation of Prostate Pathology. 人工智能在前列腺病理评估中的作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1111/pin.70015

Lars Egevad, Andrea Camilloni, Brett Delahunt, Hemamali Samaratunga, Martin Eklund, Kimmo Kartasalo

{"title":"The Role of Artificial Intelligence in the Evaluation of Prostate Pathology.","authors":"Lars Egevad, Andrea Camilloni, Brett Delahunt, Hemamali Samaratunga, Martin Eklund, Kimmo Kartasalo","doi":"10.1111/pin.70015","DOIUrl":"10.1111/pin.70015","url":null,"abstract":"Artificial intelligence (AI) is an emerging tool in diagnostic pathology, including prostate pathology. This review summarizes the possibilities offered by AI and also discusses the challenges and risks. AI has the potential to assist in the diagnosis and grading of prostate cancer. Diagnostic safety can be enhanced by avoiding the accidental underdiagnosis of small lesions. Another possible benefit is a greater degree of standardization of grading. AI for clinical use needs to be trained on large, high-quality data sets that have been assessed by experienced pathologists. A problem with the use of AI in prostate pathology is the plethora of benign mimics of prostate cancer and morphological variants of cancer that are too unusual to allow sufficient training of AI. AI systems need to be able to account for variations in local routines for cutting, staining, and scanning of slides. We also need to be aware of the risk that users will rely too much on the output of an AI system, leading to diagnostic errors and loss of clinical competence. The reporting pathologist must ultimately be responsible for accepting or rejecting the diagnosis proposed by AI.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"213-220"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nemaline bodies are not always congenital: A case of sporadic late-onset nemaline myopathy (SLONM) with monoclonal gammopathy of undetermined significance (MGUS). 线状体并不总是先天性的：1例散发性迟发性线状肌病（SLONM）合并意义不明的单克隆伽玛病（MGUS）。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-02-03 DOI: 10.1111/pin.70000

Silvie Thomas, Deepti Narasimhaiah, Sruthi S Nair, Bejoy Thomas, Rashmi Santhoshkumar, Anita Mahadevan, Rajalakshmi Poyuran

引用次数: 0

Follicular Dendritic Cell Sarcoma of the Parapharyngeal Space Arising in Association With Castleman Disease. 与Castleman病相关的咽旁间隙滤泡树突状细胞肉瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1111/pin.70007

Shunsuke Koga, Wei Du, Gabriel C Caponetti, Kumarasen Cooper

引用次数: 0

A Case of Leiomyoadenomatoid Tumor of the Epididymis Mimicking Epithelioid Mesothelioma. 附睾平滑肌腺瘤样肿瘤模拟上皮样间皮瘤1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1111/pin.70010

Aohiro Sanematsu, Kyonosuke Teruya, Kazuki Nabeshima, Kei Tanaka, Junichi Inokuchi, Akihiro Nishie, Fumi Kawakami

引用次数: 0

A Potential Case of Tubulocystic Ductal Carcinoma of the Pancreas. 胰腺小管囊性导管癌1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1111/pin.70008

Rena Uno, Yoh Zen, Tomonori Tanaka, Hirochika Toyama, Takumi Fukumoto, Keitaro Sofue, Tomoo Itoh

{"title":"A Potential Case of Tubulocystic Ductal Carcinoma of the Pancreas.","authors":"Rena Uno, Yoh Zen, Tomonori Tanaka, Hirochika Toyama, Takumi Fukumoto, Keitaro Sofue, Tomoo Itoh","doi":"10.1111/pin.70008","DOIUrl":"10.1111/pin.70008","url":null,"abstract":"We present a case of pancreatic ductal carcinoma with a microcystic appearance. A 64-year-old woman was found to have a pancreatic mass during a routine medical checkup. The tumor was well-circumscribed and multicystic; thus, she was followed up for suspected serous cystadenoma. However, the tumor gradually enlarged in the following 2.5 years; subsequently, she underwent a Whipple procedure. Grossly, the cut surface of the tumor was honeycomb-like with small cysts. Histologically, the cysts were ductal structures lined by a relatively bland, cuboidal or columnar epithelium with mildly enlarged nuclei. No intracytoplasmic mucus was observed. The presence of stromal invasion confirmed the diagnosis of ductal carcinoma. KRAS was wild type. Postoperative course was uneventful, with no recurrence to date (followup period: 5.5 years postsurgery). The present case did not meet any known subtypes of pancreatic ductal carcinoma. The tumor resembled a large duct variant, which typically shows a microcystic appearance. However, unlike the present case, the large duct type usually consists of mucus-rich neoplastic cells. A recent study on cholangiocarcinoma proposed a novel tubulocystic subtype characterized by microcystic neoplastic glands and adenofibromatous stroma, which is morphologically similar to the present case. The present case may correspond to a pancreatic counterpart of tubulocystic cholangiocarcinoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"243-246"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0