Pathology International最新文献_第5页

An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin. 肌萎缩性侧索硬化症的尸检病例报告与不寻常的嗜碱性包体显示免疫阳性的优神经蛋白。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13501

Mayu Kashiwagi-Hakozaki, Masako Ikemura, Hiroya Naruse, Yuji Takahashi, Tatsushi Toda, Tetsuo Ushiku

引用次数: 0

Two rare ALK fusion variants overlooked by multiplexed gene testing: The crucial role of immunohistochemistry in ensuring comprehensive molecular testing. 两种罕见的ALK融合变异被多重基因检测忽视：免疫组织化学在确保全面的分子检测中的关键作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1111/pin.13506

Hironori Ninomiya, Yuki Togashi, Keisuke Sugita, Kengo Takeuchi

引用次数: 0

Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma. 肺腺癌自发转化为myc扩增大细胞神经内分泌癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13507

Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka

{"title":"Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma.","authors":"Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka","doi":"10.1111/pin.13507","DOIUrl":"10.1111/pin.13507","url":null,"abstract":"Recent studies suggest that lung adenocarcinoma cells are closely associated with the tumorigenesis of large-cell neuroendocrine carcinoma via cellular transformation. However, morphological evidence, along with genetic abnormalities before, during, and after transformation, is quite limited. We present here a case of combined large-cell neuroendocrine carcinoma and adenocarcinoma exhibiting acinar and solid patterns. Adenocarcinoma cells with abundant mucin, exhibiting positivity for both napsin-A and neuroendocrine markers, were partially found in the acinar adenocarcinoma component and extensively observed in the solid adenocarcinoma component. Next-generation sequencing using extracted genomic DNA from the three components revealed homozygous TP53 (missense) and STK11 (nonsense) mutations in all three components, suggesting monoclonal origin. Furthermore, MYC gene amplification, recently presumed to be a pivotal driver in neuroendocrine transformation, was observed in both the solid adenocarcinoma and large-cell neuroendocrine carcinoma components. These genetic findings corresponded to pre- and post-transformation morphology, providing compelling evidence that some kinds of adenocarcinomas may serve as a precursor of large-cell neuroendocrine carcinoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"105-113"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer. 联合应用Efp和ZCCHC3免疫反应性预测三阴性乳腺癌患者预后。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1111/pin.13510

Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue

{"title":"Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer.","authors":"Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue","doi":"10.1111/pin.13510","DOIUrl":"10.1111/pin.13510","url":null,"abstract":"We previously reported that strong immunoreactivity (IR) of estrogen-responsive finger protein (Efp), also known as tripartite motif-containing 25 (TRIM25), predicts poor prognosis in patients with estrogen receptor-positive and -negative invasive breast cancers. In the present study, we investigated the clinicopathological role of Efp and ZCCHC3, the latter of which is an Efp interactor, in a triple-negative breast cancer (TNBC) cohort which was composed of 118 Japanese female breast cancer patients underwent surgical treatment. Efp and ZCCHC3 IRs were analyzed using specific antibodies for these proteins. We demonstrated that positive Efp IR was significantly associated with shorter distant disease-free survival (p = 0.0108) and that positive ZCCHC3 IR was also significantly associated with shorter distant disease-free survival (p = 0.0153). Notably, ZCCHC3 IR was positively associated with Efp IR (p = 0.003). When IRs of the two proteins were combined, double positivity was associated with shorter distant disease-free survival (p = 0.0007) and was an independent factor for poor prognosis. These results suggest that IR positivity of Efp and ZCCHC3 has clinical significance as a poor prognostic factor in patients with TNBC. Thus, we propose that the combined use of both IRs can be used as a prognostic marker for TNBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"92-99"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy. 腱鞘炎伴炎性钙化--扫描电子显微镜和能量色散 X 射线光谱分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1111/pin.13502

Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi

{"title":"Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy.","authors":"Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi","doi":"10.1111/pin.13502","DOIUrl":"10.1111/pin.13502","url":null,"abstract":"Tenosynovitis with psammomatous calcification (TPC) is an extremely rare condition. It was first described as a characteristic subtype of idiopathic calcifying tenosynovitis, with only 40 cases reported to date. Here, we present a case of TPC affecting a female patient in her late teens, with no relevant medical history. She presented with discomfort and pain in the right first toe. A 10-mm mushroom-like calcified mass was observed in the metatarsophalangeal joint on radiographs. The surgical specimen revealed chronic synovitis with calcification. Numerous psammomatous bodies are observed in the synovium, often with granulomatous reactions. After removal of the mass, no recurrence has been observed for 5 years. Although the etiology of TPC has been suggested to be related to repetitive trauma to the tendon or peritendinous soft tissue, the composition and mechanism of calcification remain unclear because of its rarity. In this report, we also discuss the calcification mechanism in TPC, supported by scanning electron microscopy and energy-dispersive x-ray spectroscopy findings.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"100-104"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratin-derived amyloid deposition associated with silicone granuloma in an older adult: Comprehensive analysis using immunohistochemistry, proteomics, and a literature review. 与一名老年人硅肉芽肿相关的角蛋白源性淀粉样沉积：利用免疫组化、蛋白质组学和文献综述进行综合分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1111/pin.13490

Shojiro Ichimata, Tomochika Kuroda, Tsuneaki Yoshinaga, Mitsuto Sato, Nagaaki Katoh, Fuyuki Kametani, Suzuho Onagi, Masahide Yazaki, Yoshiki Sekijima, Shin Ishizawa

引用次数: 0

Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations. BRAF和NRAS突变的软组织肿瘤与ntrk重排梭形细胞肿瘤具有共同的特征：一例报告扩大了激酶基因改变的梭形细胞肿瘤的谱。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1111/pin.13499

Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi

{"title":"Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.","authors":"Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi","doi":"10.1111/pin.13499","DOIUrl":"10.1111/pin.13499","url":null,"abstract":"NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"40-45"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report. 前纵隔成熟囊性畸胎瘤引发的分泌性腺癌：病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1111/pin.13495

Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki

{"title":"Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report.","authors":"Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki","doi":"10.1111/pin.13495","DOIUrl":"10.1111/pin.13495","url":null,"abstract":"Primary mediastinal apocrine adenocarcinoma is extremely rare, with only one case reported to date. Here, we report a surgical case of primary mediastinal apocrine adenocarcinoma. An anterior mediastinal cystic tumor with calcification was identified on chest computed tomography scan in a 51-year-old female patient undergoing maintenance hemodialysis. The tumor was 19 mm in size, did not invade the adjacent organs or show distant metastases, and was surgically removed. Microscopic examination revealed that the tumor cells exhibited cribriform or solid proliferation patterns with thick fibrous capsules. The tumor cells had an abundant eosinophilic cytoplasm, and decapitation secretion was noted. Immunohistochemistry revealed positivity for GCDFP-15 and androgen receptors, with Ki-67 positivity at 10%. The cyst wall exhibited extensive fibrosis and keratinized material, with bone and bronchial glands identified at the cyst periphery; the tumor cells were contiguous with those structures. The patient was diagnosed with apocrine adenocarcinoma arising from a mature cystic teratoma. The patient has maintained a recurrence-free status without adjuvant therapy for 6 years after surgery. This case presents a small primary mediastinal apocrine adenocarcinoma that achieved remarkable long-term survival.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"34-39"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging. 基于多光子激发成像非标记分析的光学组织病理学。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13498

Takahiro Matsui

{"title":"Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.","authors":"Takahiro Matsui","doi":"10.1111/pin.13498","DOIUrl":"10.1111/pin.13498","url":null,"abstract":"Histopathological diagnosis is the definitive method for the evaluation of disease status; however, some problems need to be solved, such as invasiveness, time consumption, and difficulty in three-dimensional observation. To overcome these problems, a novel observation method, distinct from conventional histology, using tissue sections and glass slides is desirable. Fluorescence imaging of human tissues with multiphoton excitation imaging (MpEI), which was originally used for intravital imaging in biological research, is a promising method. Label-free MpEI, which requires only near-infrared excitation, can construct images with autofluorescent signals from fresh tissues, as well as nonlinear optical phenomena. It is possible to perform real-time three-dimensional imaging of human tissues without any tissue removal, fixation, or staining. This method has been reported to be useful for histopathological classification in multiple organs and tissues. Moreover, it is very compatible with quantitative image analyses, including artificial intelligence. Based on these characteristics, label-free MpEI has sufficient potential for clinical applications such as in endoscopy and intraoperative rapid diagnosis. The clinical application of label-free MpEI will bring changes not only to histopathology examination but also the clinical bedside and will contribute to the further development of histopathology.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian mucinous cystic tumor with an overwhelming fundic gland differentiation. 卵巢粘液性囊肿伴有压迫性底腺分化。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1111/pin.13493

Satoe Numakura, Yuko Sasajima, Teppei Morikawa, Takayuki Ichinose, Kazunori Nagasaka, Masahiro Kato, Hiroshi Uozaki

引用次数: 0