Pathology International最新文献_第6页

Temporal Trends in Etiology of Aortic Valvular Diseases for Patients Undergoing Surgical Valve Replacement: A Report From 40 Years Pathological Experience. 主动脉瓣置换术患者主动脉瓣疾病病因的时间趋势：一份40年病理经验报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1111/pin.70009

Kisaki Amemiya, Hatsue Ishibashi-Ueda, Yoshihiko Ikeda, Manabu Matsumoto, Keiko Ohta-Ogo, Satsuki Fukushima, Tomoyuki Fujita, Kinta Hatakeyama

{"title":"Temporal Trends in Etiology of Aortic Valvular Diseases for Patients Undergoing Surgical Valve Replacement: A Report From 40 Years Pathological Experience.","authors":"Kisaki Amemiya, Hatsue Ishibashi-Ueda, Yoshihiko Ikeda, Manabu Matsumoto, Keiko Ohta-Ogo, Satsuki Fukushima, Tomoyuki Fujita, Kinta Hatakeyama","doi":"10.1111/pin.70009","DOIUrl":"10.1111/pin.70009","url":null,"abstract":"Although aortic valvular disease has various etiologies, recently, calcific aortic valve stenosis has been increasing. We analyzed the trends in the pathological characteristics of aortic valvular disease in the past four decades in Japan. The pathology department data for aortic valvular disease operated in our hospital documented 4508 patients from 1978 to 2022. Subsequently, trend analyses were performed over four periods: Period 1, 1978-1989 (618 cases); Period 2, 1990-1999 (903 cases); Period 3, 2000-2010 (1179 cases); and Period 4, 2011-2022 (1808 cases). We reviewed the pathological characterization of the resected aortic valves and categorized them based on the representative etiology of aortic valvular disease as congenital bicuspid, chronic rheumatic change, infective endocarditis, degenerative calcific change, and myxoid change. Our pathologic analysis revealed a significant decrease in the proportion of chronic rheumatic disease from 47% to 14%, an increase in the congenital bicuspid valve from 8% to 24%, and a rise of the degenerative calcific change of the aortic valve from 4% to 27% (p < 0.001), especially significant increases in aortic stenosis. Calcification of the aortic valve may result from an active process similar to atherosclerosis, leading to aortic stenosis with increasing dyslipidemia in Japanese patients in 40 years.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"228-235"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers. ki67标记指数在ER+/HER2-乳腺癌针芯活检标本中的可靠性

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1111/pin.70005

Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita

{"title":"Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers.","authors":"Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita","doi":"10.1111/pin.70005","DOIUrl":"10.1111/pin.70005","url":null,"abstract":"The reliability of Ki67-labeling index (LI) in core needle biopsy (CNB) of ER+/HER2- invasive breast carcinoma (IBC) and factors affecting the discordance of Ki67-LI between CNB and surgical resection (SR) remain unsolved. We aimed to elucidate factors influencing the discordance of Ki67-LI between CNB and SR to classify ER+/HER2- IBC into luminal A-like (LumA) and luminal B-like (LumB). The cohort included 326 ER+/HER2- IBCs available with Ki67-LI data at both CNB and SR specimens. Survival analysis was performed on 122 patients. Spearman's rank correlation coefficient of Ki67-LI between them was 0.683. The log-rank test showed that patients with ER+/HER2- IBC with ≥ 20% Ki67-LI at CNB (p < 0.001) and SR specimens (p < 0.001) had significantly shorter disease-free survival. In multivariate analysis, a negative PgR (p = 0.002) and > 2 cm pathological tumor size (p < 0.001) had the most significant effect on the discordance of Ki67-LI between CNB and SR at 20% and 30% cutoffs, respectively. Histological grade III had a significant effect on the concordance between them (p = 0.01) at 20% cutoff. Ki67-LI assessment in CNB may be useful for classifying ER+/HER2- IBC into LumA and LumB with caution of some prognostic factors and cutoffs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"221-227"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer. NANOG/HDAC1表达在预测非肌性浸润性膀胱癌卡介苗治疗预后中的价值

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.1111/pin.70002

Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose

{"title":"Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer.","authors":"Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose","doi":"10.1111/pin.70002","DOIUrl":"10.1111/pin.70002","url":null,"abstract":"Urinary bladder cancer includes non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). While patients with NMIBC have a better prognosis, NMIBC often recurs, requiring long-term surveillance and repeated treatments. Intravesical Bacillus Calmette-Guérin (BCG) therapy is standard for high-grade or recurrent NMIBC; however, 30%-50% of patients failed to respond, and the mechanisms of resistance remain unclear. To identify predictive biomarkers for response to intravesical BCG therapy, we analyzed NANOG and Histone deacetylase 1 (HDAC1) expression in 90 bladder cancer specimens from NMIBC patients treated with BCG therapy using immunohistochemistry. The correlation between NANOG and HDAC1 expression and clinical outcomes, including response to BCG therapy, was assessed. High-grade NMIBC cases showed significantly higher expression of NANOG and HDAC1 compared to low-grade cases (p < 0.05). Additionally, elevated NANOG expression in combination with HDAC1, was associated with poor response to BCG therapy and decreased lymphocyte infiltration in the tumor-microenvironment. NANOG is suggested to directly increases HDAC1 expression, which could suppress lymphocyte infiltration in the tumor microenvironment by altering immune-related gene expression. These findings suggest that the NANOG/HDAC1 axis plays a key role in predicting resistance to intravesical BCG therapy in NMIBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"177-183"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of presentation by the winners of The Japanese Society of Pathology; Japan Pathology Award in 2025 (in program order). 日本病理学会获奖者演讲摘要；荣获2025年日本病理学奖（按项目先后顺序）。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 DOI: 10.1111/pin.13515

引用次数: 0

Myxoid spindle cell tumor with EWSR1-CREM fusion mimicking papillary adenoma of the lung. 黏液样梭形细胞瘤与EWSR1-CREM融合，模拟肺乳头状腺瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13517

Yurie Okayama, Shin Ishizawa, Akane Aikawa, Yuko Nakanishi, Akio Uchiyama, Tomohiko Takahashi, Yasushi Yatabe

引用次数: 0

Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report. 仿畸胎性肺癌肉瘤1例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.1111/pin.70006

Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito

{"title":"Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report.","authors":"Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito","doi":"10.1111/pin.70006","DOIUrl":"10.1111/pin.70006","url":null,"abstract":"Pulmonary carcinosarcoma is a rare tumor composed of non-small-cell carcinomas and sarcomatous elements, which is poorly differentiated in most cases. We present a case of carcinosarcoma with a well-differentiated carcinomatous component that required a differential diagnosis from tumors derived from teratomas, such as teratocarcinosarcoma. We present a case of a 68-year-old man who visited our hospital for an examination of a 22-mm lung tumor. The patient underwent left S1+2 segmentectomy, and his postoperative course was uneventful. No recurrence was observed in the 21-month postoperative follow-up period. The segmentectomy specimen revealed a yellow-white, well-circumscribed mass. The tumor consisted of well-differentiated squamous and glandular epithelia, and sarcomatous components of immature spindle cells, chondrosarcoma, and rhabdomyosarcoma. The patient was diagnosed with carcinosarcoma. This case included well-differentiated carcinomatous components, and it was necessary to differentiate it from teratocarcinosarcomas. There was no neural component, and without SMARCA4 loss, which is observed in teratocarcinosarcoma, and ruled out teratocarcinosarcoma. Carcinosarcomas are characterized by a biphasic histopathological pattern, making it difficult to accurately diagnose them on biopsy, which only captures a portion of the tumor. The possibility of carcinosarcoma should be considered even when the tumors derived from teratomas are suspected on preoperative biopsy.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"196-202"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical choroid plexus papilloma arising in a mature ovarian teratoma, a case report. 不典型脉络丛乳头状瘤产生于成熟卵巢畸胎瘤1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13513

Brandon Gehris, Songlin Zhang, Xiaohong Iris Wang

引用次数: 0

A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer. 一种改进的乳腺癌he染色切片肿瘤浸润淋巴细胞评价系统的建议。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1111/pin.70004

Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda

{"title":"A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer.","authors":"Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda","doi":"10.1111/pin.70004","DOIUrl":"10.1111/pin.70004","url":null,"abstract":"Tumor-infiltrating lymphocyte (TIL) scoring in tumor specimens has gained increasing attention in determining patients who are likely to benefit from immunotherapies. However, the histological evaluation methods of TILs in breast cancer remain limited. This study aimed to assess four components of lymphocytic reaction and overall lymphocytic score (L-score) used in colorectal cancer, investigate its association with clinicopathological factors, and examine the effect of TILs on postoperative mortality using 231 invasive breast cancers without neoadjuvant chemotherapy. Besides L-score, increasing modified L-score lacking peritumoral lymphocytic reaction was significantly associated with aggressive breast cancer phenotypes, including larger invasive size, higher tumor stage, higher Ki-67 labeling index, triple negative and HER2-enriched subtypes, and higher Nottingham histological grade. Importantly, modified L-score status but not L-score or TIL-Working Group (WG) score status was positively correlated with the disease-specific survival rate of the overall patients as well as the patients with luminal type or histological Grade III breast cancers. These results indicated that the modified L-score is a favorable method to comprehensively assess lymphocytic reaction to predict prognosis among patients with breast cancer, even compared with the currently used TIL-WG method, which may possess their potential integration into clinical practice.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"184-195"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichosporon hyphae should be carefully differentiated from Aspergillus hyphae in tissue: A case report. 应仔细区分组织中的毛丝虫丝和曲霉丝：1例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13514

Masatomo Kimura, Fumiaki Ono, Takaaki Chikugo, Takashi Sugita

引用次数: 0

SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells. SLC13A5在顺铂耐药间皮瘤干细胞向氧化磷酸化的能量转移中起重要作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1111/pin.70001

Marie Kato-Shinomiya, Hirokazu Sugino, Lei Wang, Yusuke Saito, Jintao He, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Mishie Tanino, Jian Ping Gong, Masumi Tsuda, Shinya Tanaka

{"title":"SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells.","authors":"Marie Kato-Shinomiya, Hirokazu Sugino, Lei Wang, Yusuke Saito, Jintao He, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Mishie Tanino, Jian Ping Gong, Masumi Tsuda, Shinya Tanaka","doi":"10.1111/pin.70001","DOIUrl":"10.1111/pin.70001","url":null,"abstract":"Mesothelioma is a highly aggressive tumor affecting an increasing number of patients worldwide. Owing to the poor clinical outcomes associated with current therapies, the development of novel therapies that target cancer stem cells (CSCs) is desirable. Here, we examined the applicability of our previously established hydrogel-based rapid CSC generation method to human mesothelioma cell lines and further analyzed the characteristics of the induced mesothelioma stem cell (MesoSC) -like cells. Human mesothelioma cell lines cultured on hydrogels presented increased expression of pan-stem cell markers and acquired spheroid formation and early tumorigenicity, suggesting that MesoSC-like cells are highly malignant. Microarray analysis demonstrated that the expression of SLC13A5, a citrate transporter involved in TCA cycle, was significantly induced in the resulting MesoSC-like cells. The overexpression of SLC13A5 resulted in a metabolic shift toward oxidative phosphorylation, increased phosphorylation of ERK and YAP, and increased SOX2 expression, leading to increased cisplatin resistance. scRNA-seq database analysis revealed that clinical mesothelioma samples contained a small number of SLC13A5-expressing cells. Our findings suggest that the hydrogel-based CSC generation method is also effective for human mesothelioma cells and that SLC13A5 may contribute to MesoSC survival. The new properties of MesoSCs revealed in this study may provide clues for establishing future treatments.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"151-165"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0