Pathology International最新文献_第6页

Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue. 间充质间质细胞超氧化物歧化酶2缺乏可引起交感神经断神经和棕色脂肪组织功能损伤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-06 DOI: 10.1111/pin.13503

Yuya Urano, Shinji Mii, Shun Asai, Nobutoshi Esaki, Ryota Ando, Yukihiro Shiraki, Tadashi Iida, Katsuhiro Kato, Mika Hori, Yoshitaka Hayashi, Takahiko Shimizu, Atsushi Enomoto

{"title":"Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue.","authors":"Yuya Urano, Shinji Mii, Shun Asai, Nobutoshi Esaki, Ryota Ando, Yukihiro Shiraki, Tadashi Iida, Katsuhiro Kato, Mika Hori, Yoshitaka Hayashi, Takahiko Shimizu, Atsushi Enomoto","doi":"10.1111/pin.13503","DOIUrl":"10.1111/pin.13503","url":null,"abstract":"Brown adipose tissue (BAT) is an energy-consuming organ, and its functional dysregulation contributes to the development of metabolic diseases and obesity. BAT function is regulated by the sympathetic nervous system but declines with age, which is partly caused by reduced sympathetic nerve fibers innervating BAT. Thus far, the role of mesenchymal stromal/stem cells in age-related BAT dysfunction remains unknown. Here, we show that BAT dysfunction may be induced by a defect in the antioxidant capacity of stromal cells that localize in and around the nerve fibers (perineurial cells) of BAT. These cells express Meflin, a marker of mesenchymal stromal/stem cells. Specific deletion of the antioxidant enzyme superoxide dismutase 2 in Meflin-lineage cells caused sympathetic denervation and whitening of BAT and its functional impairment, as exemplified by a decline in the fat oxidation rate during the daytime. This phenotype was accompanied by overexpression of the neurorepulsive factor semaphorin 3A in perineurial cells. Notably, Meflin-deficient mice exhibited resistance to doxorubicin-induced BAT dysfunction. These results highlight the role of Meflin+ stromal cells, including perineurial cells, in maintaining BAT function and suggest that targeting BAT stromal cells provides a new avenue for improving BAT function.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"69-81"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of osteoclasts in pathological conditions. 破骨细胞在病理状态中的作用

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-20 DOI: 10.1111/pin.13500

Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa

{"title":"Roles of osteoclasts in pathological conditions.","authors":"Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa","doi":"10.1111/pin.13500","DOIUrl":"10.1111/pin.13500","url":null,"abstract":"Bone is a unique organ crucial for locomotion, mineral metabolism, and hematopoiesis. It maintains homeostasis through a balance between bone formation by osteoblasts and bone resorption by osteoclasts, which is regulated by the basic multicellular unit (BMU). Abnormal bone metabolism arises from an imbalance in the BMU. Osteoclasts, derived from the monocyte-macrophage lineage, are regulated by the RANKL-RANK-OPG system, which is a key factor in osteoclast differentiation. RANKL activates osteoclasts through its receptor RANK, while OPG acts as a decoy receptor that inhibits RANKL. In trabecular bone, high turnover involves rapid bone formation and resorption, influenced by conditions such as malignancy and inflammatory cytokines that increase RANKL expression. Cortical bone remodeling, regulated by aged osteocytes expressing RANKL, is less understood, despite ongoing research into how Rett syndrome, characterized by MeCP2 abnormalities, affects RANKL expression. Balancing trabecular and cortical bone involves mechanisms that preserve cortical bone, despite overall bone mass reduction due to aging or oxidative stress. Research into genes like sFRP4, which modulates bone mass, highlights the complex regulation by BMUs. The roles of the RANKL-RANK-OPG system extend beyond bone, affecting processes such as aortic valve formation and temperature regulation, which highlight the interconnected nature of biological research.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"55-68"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer. 食管癌中核梭杆菌定位/分布的组织病理学研究。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-06 DOI: 10.1111/pin.13505

Iku Sasaki-Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki

{"title":"Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer.","authors":"Iku Sasaki-Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki","doi":"10.1111/pin.13505","DOIUrl":"10.1111/pin.13505","url":null,"abstract":"Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH). Tissues collected from 70 patients with esophageal squamous cell carcinoma were examined using FISH. Corresponding normal epithelium and metastatic lymph nodes were assessed. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. F. nucleatum also showed significant correlation with factors associated with tumor progression, such as pT factor and tumor size. As tumor progression advanced, the area occupied by F. nucleatum gradually became larger. F. nucleatum positivity was observed around the deep edge of the tumor nest (border-dense type) or identified diffusely in the tumor nest (diffuse distributed type). Furthermore, F. nucleatum was observed in metastatic lymph nodes, lesions of venous invasion, and walls of veins in normal epithelium. In conclusion, we visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. Recognizing this quantitative change is pivotal for establishing F. nucleatum as a reliable biomarker.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"82-91"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin. 肌萎缩性侧索硬化症的尸检病例报告与不寻常的嗜碱性包体显示免疫阳性的优神经蛋白。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13501

Mayu Kashiwagi-Hakozaki, Masako Ikemura, Hiroya Naruse, Yuji Takahashi, Tatsushi Toda, Tetsuo Ushiku

引用次数: 0

Two rare ALK fusion variants overlooked by multiplexed gene testing: The crucial role of immunohistochemistry in ensuring comprehensive molecular testing. 两种罕见的ALK融合变异被多重基因检测忽视：免疫组织化学在确保全面的分子检测中的关键作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1111/pin.13506

Hironori Ninomiya, Yuki Togashi, Keisuke Sugita, Kengo Takeuchi

引用次数: 0

Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma. 肺腺癌自发转化为myc扩增大细胞神经内分泌癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13507

Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka

{"title":"Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma.","authors":"Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka","doi":"10.1111/pin.13507","DOIUrl":"10.1111/pin.13507","url":null,"abstract":"Recent studies suggest that lung adenocarcinoma cells are closely associated with the tumorigenesis of large-cell neuroendocrine carcinoma via cellular transformation. However, morphological evidence, along with genetic abnormalities before, during, and after transformation, is quite limited. We present here a case of combined large-cell neuroendocrine carcinoma and adenocarcinoma exhibiting acinar and solid patterns. Adenocarcinoma cells with abundant mucin, exhibiting positivity for both napsin-A and neuroendocrine markers, were partially found in the acinar adenocarcinoma component and extensively observed in the solid adenocarcinoma component. Next-generation sequencing using extracted genomic DNA from the three components revealed homozygous TP53 (missense) and STK11 (nonsense) mutations in all three components, suggesting monoclonal origin. Furthermore, MYC gene amplification, recently presumed to be a pivotal driver in neuroendocrine transformation, was observed in both the solid adenocarcinoma and large-cell neuroendocrine carcinoma components. These genetic findings corresponded to pre- and post-transformation morphology, providing compelling evidence that some kinds of adenocarcinomas may serve as a precursor of large-cell neuroendocrine carcinoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"105-113"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer. 联合应用Efp和ZCCHC3免疫反应性预测三阴性乳腺癌患者预后。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1111/pin.13510

Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue

{"title":"Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer.","authors":"Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue","doi":"10.1111/pin.13510","DOIUrl":"10.1111/pin.13510","url":null,"abstract":"We previously reported that strong immunoreactivity (IR) of estrogen-responsive finger protein (Efp), also known as tripartite motif-containing 25 (TRIM25), predicts poor prognosis in patients with estrogen receptor-positive and -negative invasive breast cancers. In the present study, we investigated the clinicopathological role of Efp and ZCCHC3, the latter of which is an Efp interactor, in a triple-negative breast cancer (TNBC) cohort which was composed of 118 Japanese female breast cancer patients underwent surgical treatment. Efp and ZCCHC3 IRs were analyzed using specific antibodies for these proteins. We demonstrated that positive Efp IR was significantly associated with shorter distant disease-free survival (p = 0.0108) and that positive ZCCHC3 IR was also significantly associated with shorter distant disease-free survival (p = 0.0153). Notably, ZCCHC3 IR was positively associated with Efp IR (p = 0.003). When IRs of the two proteins were combined, double positivity was associated with shorter distant disease-free survival (p = 0.0007) and was an independent factor for poor prognosis. These results suggest that IR positivity of Efp and ZCCHC3 has clinical significance as a poor prognostic factor in patients with TNBC. Thus, we propose that the combined use of both IRs can be used as a prognostic marker for TNBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"92-99"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy. 腱鞘炎伴炎性钙化--扫描电子显微镜和能量色散 X 射线光谱分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1111/pin.13502

Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi

{"title":"Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy.","authors":"Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi","doi":"10.1111/pin.13502","DOIUrl":"10.1111/pin.13502","url":null,"abstract":"Tenosynovitis with psammomatous calcification (TPC) is an extremely rare condition. It was first described as a characteristic subtype of idiopathic calcifying tenosynovitis, with only 40 cases reported to date. Here, we present a case of TPC affecting a female patient in her late teens, with no relevant medical history. She presented with discomfort and pain in the right first toe. A 10-mm mushroom-like calcified mass was observed in the metatarsophalangeal joint on radiographs. The surgical specimen revealed chronic synovitis with calcification. Numerous psammomatous bodies are observed in the synovium, often with granulomatous reactions. After removal of the mass, no recurrence has been observed for 5 years. Although the etiology of TPC has been suggested to be related to repetitive trauma to the tendon or peritendinous soft tissue, the composition and mechanism of calcification remain unclear because of its rarity. In this report, we also discuss the calcification mechanism in TPC, supported by scanning electron microscopy and energy-dispersive x-ray spectroscopy findings.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"100-104"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratin-derived amyloid deposition associated with silicone granuloma in an older adult: Comprehensive analysis using immunohistochemistry, proteomics, and a literature review. 与一名老年人硅肉芽肿相关的角蛋白源性淀粉样沉积：利用免疫组化、蛋白质组学和文献综述进行综合分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1111/pin.13490

Shojiro Ichimata, Tomochika Kuroda, Tsuneaki Yoshinaga, Mitsuto Sato, Nagaaki Katoh, Fuyuki Kametani, Suzuho Onagi, Masahide Yazaki, Yoshiki Sekijima, Shin Ishizawa

引用次数: 0

Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations. BRAF和NRAS突变的软组织肿瘤与ntrk重排梭形细胞肿瘤具有共同的特征：一例报告扩大了激酶基因改变的梭形细胞肿瘤的谱。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1111/pin.13499

Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi

{"title":"Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.","authors":"Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi","doi":"10.1111/pin.13499","DOIUrl":"10.1111/pin.13499","url":null,"abstract":"NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"40-45"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0