Pathology International最新文献

Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy. 腱鞘炎伴炎性钙化--扫描电子显微镜和能量色散 X 射线光谱分析。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-13 DOI: 10.1111/pin.13502

Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi

{"title":"Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy.","authors":"Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi","doi":"10.1111/pin.13502","DOIUrl":"https://doi.org/10.1111/pin.13502","url":null,"abstract":"Tenosynovitis with psammomatous calcification (TPC) is an extremely rare condition. It was first described as a characteristic subtype of idiopathic calcifying tenosynovitis, with only 40 cases reported to date. Here, we present a case of TPC affecting a female patient in her late teens, with no relevant medical history. She presented with discomfort and pain in the right first toe. A 10-mm mushroom-like calcified mass was observed in the metatarsophalangeal joint on radiographs. The surgical specimen revealed chronic synovitis with calcification. Numerous psammomatous bodies are observed in the synovium, often with granulomatous reactions. After removal of the mass, no recurrence has been observed for 5 years. Although the etiology of TPC has been suggested to be related to repetitive trauma to the tendon or peritendinous soft tissue, the composition and mechanism of calcification remain unclear because of its rarity. In this report, we also discuss the calcification mechanism in TPC, supported by scanning electron microscopy and energy-dispersive x-ray spectroscopy findings.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-11 DOI: 10.1111/pin.13498

Takahiro Matsui

{"title":"Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.","authors":"Takahiro Matsui","doi":"10.1111/pin.13498","DOIUrl":"https://doi.org/10.1111/pin.13498","url":null,"abstract":"Histopathological diagnosis is the definitive method for the evaluation of disease status; however, some problems need to be solved, such as invasiveness, time consumption, and difficulty in three-dimensional observation. To overcome these problems, a novel observation method, distinct from conventional histology, using tissue sections and glass slides is desirable. Fluorescence imaging of human tissues with multiphoton excitation imaging (MpEI), which was originally used for intravital imaging in biological research, is a promising method. Label-free MpEI, which requires only near-infrared excitation, can construct images with autofluorescent signals from fresh tissues, as well as nonlinear optical phenomena. It is possible to perform real-time three-dimensional imaging of human tissues without any tissue removal, fixation, or staining. This method has been reported to be useful for histopathological classification in multiple organs and tissues. Moreover, it is very compatible with quantitative image analyses, including artificial intelligence. Based on these characteristics, label-free MpEI has sufficient potential for clinical applications such as in endoscopy and intraoperative rapid diagnosis. The clinical application of label-free MpEI will bring changes not only to histopathology examination but also the clinical bedside and will contribute to the further development of histopathology.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin.

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-11 DOI: 10.1111/pin.13501

Mayu Kashiwagi-Hakozaki, Masako Ikemura, Hiroya Naruse, Yuji Takahashi, Tatsushi Toda, Tetsuo Ushiku

引用次数: 0

Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation.

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-11 DOI: 10.1111/pin.13496

Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura

{"title":"Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation.","authors":"Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura","doi":"10.1111/pin.13496","DOIUrl":"https://doi.org/10.1111/pin.13496","url":null,"abstract":"CD5 expression is seen in 5%-10% of de novo diffuse large B-cell lymphomas (DLBCLs). Primary large B-cell lymphoma of the central nervous system (PCNS-LBCL) also exhibits CD5 expression in a minority of cases, however, clinicopathological and molecular features remain largely unclarified. Here we present the clinical, molecular, and pathological features of 11 CD5-positive (+) PCNS-LBCL cases, occupying 6.7% of all 165 PCNS-LBCLs diagnosed in our institutions. While CD5+ systemic DLBCL has been recognized as a distinctive subgroup showing an aggressive clinical course, no obvious differences were found between CD5+ and CD5-negative subgroups among the present CNS patients clinically. MYD88 p.L265P and CD79B p.Y196 mutations were detected in eight (73%) and seven (64%) cases, respectively, supporting previous reports. Notably, the microenvironmental immune cells were universally PD-L1/CD274-positive, and the higher levels tended to present favorable overall survival, as already evidenced in the PCNS-LBCL series. In contrast, neoplastic PD-L1/CD274 expression was undetectable in all cases. Indeed, no structural variations or copy number alterations involving PD-1 ligands were detected by targeted-capture sequencing and fluorescence in situ hybridization. While further studies are warranted, we may have confirmed similarity between PCNS-LBCLs and intravascular large B-cell lymphomas from a molecular standpoint.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-06 DOI: 10.1111/pin.13499

Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi

{"title":"Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.","authors":"Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi","doi":"10.1111/pin.13499","DOIUrl":"https://doi.org/10.1111/pin.13499","url":null,"abstract":"NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMARCB1-deficient malignant neoplasm of the pancreas with heterogeneous morphologies that cannot be classified into existing histologic types. SMARCB1缺陷型胰腺恶性肿瘤，形态不一，无法归入现有组织学类型。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1111/pin.13489

Yusuke Kouchi, Nozomu Sakai, Sakurako Harada-Kagitani, Ryotaro Eto, Takashi Mishima, Shigetsugu Takano, Katsuhiro Nasu, Jun-Ichiro Ikeda, Masayuki Ohtsuka, Takashi Kishimoto

{"title":"SMARCB1-deficient malignant neoplasm of the pancreas with heterogeneous morphologies that cannot be classified into existing histologic types.","authors":"Yusuke Kouchi, Nozomu Sakai, Sakurako Harada-Kagitani, Ryotaro Eto, Takashi Mishima, Shigetsugu Takano, Katsuhiro Nasu, Jun-Ichiro Ikeda, Masayuki Ohtsuka, Takashi Kishimoto","doi":"10.1111/pin.13489","DOIUrl":"10.1111/pin.13489","url":null,"abstract":"A 50-year-old male with a pancreatic tail tumor underwent distal pancreatectomy. At 14 and 27 months after the primary surgery, metachronous liver metastases were identified and partial hepatectomies were performed for each. Pathologic findings of the primary pancreatic tumor were heterogeneous, but they essentially categorized into two components based on their cytologic features: (i) clear cell component and (ii) epithelioid cell component. The metastatic hepatic tumor was entirely composed of the epithelioid cell component. SMARCB1 expression was lost by immunohistochemistry and heterozygous deletion of SMARCB1 was identified by fluorescence in situ hybridization for both the primary and metastatic tumors. Targeted DNA sequencing of a metastatic hepatic tumor sample was performed and SMARCB1 loss was identified. Based on the morphologic, immunohistochemical, and molecular analyzes, the present case was difficult to classify into any of the existing entities. SMARCB1 deficiency might play a key role in the tumorigenesis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"691-696"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain biopsy and pathological diagnosis for drug-associated progressive multifocal leukoencephalopathy (PML) with inflammatory reactions. 与药物相关的伴有炎症反应的进行性多灶性白质脑病（PML）的脑活检和病理诊断。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1111/pin.13492

Yukiko Shishido-Hara

{"title":"Brain biopsy and pathological diagnosis for drug-associated progressive multifocal leukoencephalopathy (PML) with inflammatory reactions.","authors":"Yukiko Shishido-Hara","doi":"10.1111/pin.13492","DOIUrl":"10.1111/pin.13492","url":null,"abstract":"Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by JC virus (JCV) infection. Although recognized as an AIDS complication in the 1980s, PML has emerged as a serious adverse event of immunosuppressive therapies since 2005, particularly disease-modifying drugs (DMDs) for multiple sclerosis (MS). PML can also occur in patients with collagenous diseases receiving steroid therapy or with age-related immunosuppression. In some cases, the etiology of immunosuppression remains unclear. These cases often present with early manifestations of PML, which, while common, are less well recognized, as PML was identified at more advanced stages in AIDS-related cases. Early diagnosis poses difficulty due to unfamiliar magnetic resonance (MR) images and low viral loads in cerebrospinal fluid (CSF), and brain biopsy may be conducted. This review summarizes the PML pathology identified through biopsy. Early cytopathological changes of JCV-infected cells, with the importance of dot-shaped inclusions associated with promyelocytic leukemia nuclear bodies (PML-NBs), are described. The variability of host immune responses, including PML immune reconstitution inflammatory syndrome (PML-IRIS), is addressed. The potential role of immune checkpoint inhibitors (ICIs), such as pembrolizumab, is also explored. Understanding the pathology of early PML helps to optimize diagnostic strategies and therapeutic interventions, ultimately improving prognosis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"673-681"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread benign HNF1β-positive solid nests from the urethral diverticulum to the bladder neck: Is it a mesonephric remnant? 从尿道憩室到膀胱颈的广泛良性HNF1β阳性实性巢：是肾间质残余吗？

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1111/pin.13486

Takahiro Kirisawa, Akiko Miyagi Maeshima, Tomoya Okuno, Ayumu Matsuda, Yoshiyuki Matsui

引用次数: 0

SMARCB1-deficient renal medullary carcinoma with an EML4::ALK fusion gene in a Japanese woman. 一名日本女性患上带有 EML4::ALK 融合基因的 SMARCB1 缺失型肾髓质癌。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1111/pin.13494

Megumi Nobuoka, Tatsuya Mukawa, Mai Iwaya, Shohei Shigeto, Tomonori Minagawa, Takeshi Uehara, Yoshiyuki Akiyama

引用次数: 0

Multifocal meningoencephalitis after vaccination against COVID-19. 接种 COVID-19 疫苗后出现多灶性脑膜脑炎。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1111/pin.13491

Shuji Mikami, Mitsuru Ishii, Tetsuhiro Yano, Ichiro Hirayama, Yuichiro Hayashi, Takayuki Shiomi, Yoshiteru Tominaga, Tsuyoshi Ishida

{"title":"Multifocal meningoencephalitis after vaccination against COVID-19.","authors":"Shuji Mikami, Mitsuru Ishii, Tetsuhiro Yano, Ichiro Hirayama, Yuichiro Hayashi, Takayuki Shiomi, Yoshiteru Tominaga, Tsuyoshi Ishida","doi":"10.1111/pin.13491","DOIUrl":"10.1111/pin.13491","url":null,"abstract":"We report the case of an 84-year-old male patient who was transferred to our hospital because of impaired consciousness and high fever, and died about 10 weeks after his fourth \"coronavirus disease 2019\" (COVID-19) vaccination. Autopsy revealed acute ischemic change with microhemorrhage and perivascular T-cell infiltration in the thalamus, pons, and cerebellum, which were considered to be related to neurological symptoms. There were dilatation of the right ventricle, accumulation of pleural effusion, and ascites, suggesting right heart failure. Although the patient had a negative COVID-19 polymerase chain reaction test, immunohistochemical analysis for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens (spike and nucleocapsid proteins) was performed to identify the cause of death. Surprisingly, only SARS-CoV-2 spike protein was detected in the thalamus, pons, and pituitary and adrenal glands. The presence of SARS-CoV-2 spike protein might have been due to vaccination rather than viral infection, because no SARS-CoV-2 nucleocapsid protein was detected. The spike protein in the central nervous system might have been related to the acute ischemic change, and that in the pituitary and adrenal glands may have been associated with right heart failure, possibly through dysfunction of the renin-angiotensin-aldosterone system.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"697-703"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0