Pathology International最新文献

Unusual Case of a Sporadic Juvenile Polyp Coexisting With Traditional Serrated Adenoma in the Colon. 散发性幼年息肉与传统的锯齿状腺瘤在结肠内共存的罕见病例。

IF 3.4 4区医学

Pathology International Pub Date : 2025-10-01 DOI: 10.1111/pin.70053

Kazutaka Gomisawa, Yuuki Nishimura, Taisuke Mori, Eijitsu Ryo, Kazuki Sumiyama, Naoto Tamai, Ayako Tasaki, Masayuki Shimoda

引用次数: 0

ALK-Rearranged Mesenchymal Neoplasm With Hyaline-Vascular Castleman Disease-Like Features: A Case Report. alk重排间充质肿瘤伴透明血管样Castleman病1例

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-26 DOI: 10.1111/pin.70052

Haruna Yagi, Akira Satou, Yasunori Enomoto, Mayu Fujihiro, Yuichi Yamada, Yukihiro Yokoyama, Satoshi Baba, Toshihide Iwashita, Kennosuke Karube

{"title":"ALK-Rearranged Mesenchymal Neoplasm With Hyaline-Vascular Castleman Disease-Like Features: A Case Report.","authors":"Haruna Yagi, Akira Satou, Yasunori Enomoto, Mayu Fujihiro, Yuichi Yamada, Yukihiro Yokoyama, Satoshi Baba, Toshihide Iwashita, Kennosuke Karube","doi":"10.1111/pin.70052","DOIUrl":"https://doi.org/10.1111/pin.70052","url":null,"abstract":"Recent reports have revealed various morphological features of ALK-rearranged mesenchymal neoplasms but their characteristics remain to be elucidated. Here, we report a case of ALK-rearranged mesenchymal neoplasm with novel morphological features. A 32-year-old man had an intra-abdominal mass measuring 75 mm in diameter. Histologically, the tumor consisted of many lymphoid follicles with wide fibrosis or hyalinization. The follicles were characterized by regressed germinal centers and expanded mantle zones. Hyalinized blood vessels were distributed in the follicular and interfollicular areas. These histological findings resembled those of hyaline-vascular type unicentric Castleman disease (HV-UCD). However, the fibrous areas exhibited histological findings similar to inflammatory myofibroblastic tumor (IMT), which is characterized by the proliferation of spindle or stellate-shaped fibroblastic cells accompanied by lymphoid, eosinophil, and plasma cell infiltration. Immunohistochemically, ALK-positive spindle cells were observed in the follicular, interfollicular, and fibrous areas. Molecular analysis revealed fusion between ATIC (exon 7) and ALK (exon 20). Immunofluorescence staining suggested that ALK-positive tumor cells in follicular areas were derived from CD23-positive follicular dendritic cells, and those in interfollicular areas were derived from α-SMA-positive fibroblastic reticular cells or myofibroblasts. Therefore, we report an extremely rare case of ALK-rearranged mesenchymal neoplasm with features of both HV-UCD and IMT.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric PLAG1-Rearranged Fibromyxoid Spindle Cell Tumor: An Emerging Distinct Entity or a Fibroblastic ('Non-Lipogenic') Pattern of Lipoblastoma? 小儿plag1重排纤维黏液样梭形细胞瘤：一种新兴的独特实体还是脂肪母细胞瘤的纤维母细胞（“非脂源性”）模式？

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-23 DOI: 10.1111/pin.70054

Fleur Cordier, Siebe Loontiens, Joni Van der Meulen, Liesbeth Ferdinande, David Creytens

引用次数: 0

Two Cases of Diffuse Pleural Mesothelioma Discovered After Spontaneous Pneumothorax. 自发性气胸后发现弥漫性胸膜间皮瘤2例。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-19 DOI: 10.1111/pin.70051

Yuki Kato, Susumu Kirimura, Eisaku Ito, Ichiro Kasahara, Kenichi Ohashi

引用次数: 0

Germinomas: Nestin and CD15 Expression in Tumor Blood Vessels. 生殖细胞瘤：巢蛋白和CD15在肿瘤血管中的表达。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-16 DOI: 10.1111/pin.70050

Carlos Alcalá-Romero, Ana Laura Calderón-Garcidueñas, Sanjuana Berenice Treviño-Solís, Carlos Eduardo Dieguez-Campa, Rebeca Ramos-Sánchez

引用次数: 0

Extraction of Novel Features and Diagnosis Prediction in Myelodysplastic Neoplasm Using a Weakly Supervised Artificial Intelligence Model Based on Normal Megakaryocytes. 基于正常巨核细胞的弱监督人工智能模型提取骨髓增生异常肿瘤新特征及诊断预测。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-16 DOI: 10.1111/pin.70049

Sosuke Ishijima, Ethan N Okoshi, Makoto Kawamoto, Ryuta Matsuda, Takuma Odate, Kamran M Mirza, Junya Fukuoka

{"title":"Extraction of Novel Features and Diagnosis Prediction in Myelodysplastic Neoplasm Using a Weakly Supervised Artificial Intelligence Model Based on Normal Megakaryocytes.","authors":"Sosuke Ishijima, Ethan N Okoshi, Makoto Kawamoto, Ryuta Matsuda, Takuma Odate, Kamran M Mirza, Junya Fukuoka","doi":"10.1111/pin.70049","DOIUrl":"https://doi.org/10.1111/pin.70049","url":null,"abstract":"Evaluation of bone marrow pathology can be challenging for nonspecialist pathologists due to its morphological complexities. Despite advances in artificial intelligence for other organ systems, research in bone marrow biopsy field remains limited. This study presents an artificial intelligence model developed to classify myeloid diseases based on morphologically normal megakaryocytes in hematoxylin-eosin-stained bone marrow biopsy specimens. The model integrates two deep learning components: one for detecting bone marrow regions, and the other for identifying megakaryocytes, along with an XGBoost-based classifier that leverages extracted features to differentiate between normal cases, myelodysplastic neoplasm, and immune thrombocytopenic purpura. The model achieved exceptional accuracy, with area under the curve values of 0.9996 (bone marrow detection) and 0.9997 (megakaryocyte detection). For disease classification, myelodysplastic neoplasm versus normal performed well, with an area under the curve of 0.879. Feature analysis revealed that the percentage of megakaryocyte among all cells and the number of adjacent megakaryocytes within various distances were significantly correlated with disease prediction. This study introduces the first artificial intelligence model capable of classifying myelodysplastic neoplasm versus normal based on normal megakaryocyte morphology. This model demonstrates potential not only for diagnostic assistance but also for uncovering novel histological features.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145070260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-Myc Overexpression in Adolescent and Young Adult Breast Cancer: Distinct From Older Adults With Relevantly Expressed Cholecystokinin B Receptor. C-Myc在青少年和青年乳腺癌中的过表达：与胆囊收缩素B受体相关表达的老年人不同

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI: 10.1111/pin.70047

Tomoyuki Tanino, Yoko Nakanishi, Haruna Nishimaki-Watanabe, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Yukari Hirotani, Sachie Hashimoto, Chie Watanabe, Hiroko Bando, Chikako Shimizu, Shinobu Masuda

{"title":"C-Myc Overexpression in Adolescent and Young Adult Breast Cancer: Distinct From Older Adults With Relevantly Expressed Cholecystokinin B Receptor.","authors":"Tomoyuki Tanino, Yoko Nakanishi, Haruna Nishimaki-Watanabe, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Yukari Hirotani, Sachie Hashimoto, Chie Watanabe, Hiroko Bando, Chikako Shimizu, Shinobu Masuda","doi":"10.1111/pin.70047","DOIUrl":"10.1111/pin.70047","url":null,"abstract":"Breast cancer in adolescents and young adults has poorer clinical outcomes, but the role of MYC in this group remains unclear. We aimed to elucidate the characteristics of MYC expression in breast cancer among adolescents and young adults. MYC expression in 42 adolescents and young adults and 110 older adults were analyzed using immunohistochemistry, fluorescence in situ hybridization, quantitative polymerase chain reaction, and RNA sequencing. Immunohistochemical c-myc expression was higher in adolescents and young adults group compared to older adults, without MYC gene amplification. In older adults, c-myc expression was associated with more aggressive features. Adolescents and young adults group showed higher c-myc expression even in tumors with less aggressive features, such as estrogen receptor positive, low Ki-67 labeling index, and early clinical stage, than older adults. RNA sequencing revealed higher expression of cholecystokinin B receptor and lower expression of uridine diphosphate glucuronosyltransferase 2 family member B4 in c-myc positive tumors of adolescents and young adults group. The preference of positive cases for both c-myc and cholecystokinin B receptor was significantly higher in adolescents and young adults group. In conclusion, c-myc overexpression makes adolescents and young adults breast cancer more aggressive through multifaceted roles including relevantly expressed cholecystokinin B receptor. Clinical trial registration: This study is not a clinical trial.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"459-470"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the IASLC Grading and Other Pathological Features on Relapse and Survival in Completely Resected Lung Adenocarcinoma by EGFR Mutation Status: A Supplementary Analysis of the CReGYT-01 EGFR Study. IASLC分级和其他病理特征对EGFR突变状态下完全切除肺腺癌复发和生存的影响：对CReGYT-01 EGFR研究的补充分析

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-13 DOI: 10.1111/pin.70044

Hironobu Hoshino, Shinya Katsumata, Akira Hamada, Naoki Haratake, Kyoshiro Takegahara, Shoko Nakasone, Hidenori Kawasaki, Mototsugu Shimokawa, Satoshi Shiono, Junichi Soh, Yasuhisa Ohde

{"title":"Impact of the IASLC Grading and Other Pathological Features on Relapse and Survival in Completely Resected Lung Adenocarcinoma by EGFR Mutation Status: A Supplementary Analysis of the CReGYT-01 EGFR Study.","authors":"Hironobu Hoshino, Shinya Katsumata, Akira Hamada, Naoki Haratake, Kyoshiro Takegahara, Shoko Nakasone, Hidenori Kawasaki, Mototsugu Shimokawa, Satoshi Shiono, Junichi Soh, Yasuhisa Ohde","doi":"10.1111/pin.70044","DOIUrl":"10.1111/pin.70044","url":null,"abstract":"This study aimed to clarify the risk factors for recurrence in epidermal growth factor receptor (EGFR) mutated and wild-type lung adenocarcinomas, with a focus on the newly proposed International Association for the Study of Lung Cancer (IASLC) grading system. We enrolled 2106 patients who underwent complete anatomical radical resection and had a known EGFR mutational status and IASLC grade. Patient characteristics and pathological features were analyzed to assess the cumulative incidence of recurrence (CIR). No significant differences were found in the CIR between the EGFR mutated (EGFRm) and wild-type groups. In the EGFRm group, multivariate analysis identified IASLC grade 2, grade 3 (reference: grade 1), pathological stage II/III, lymphatic invasion (ly), vessel invasion (v), and plural invasion as independent risk factors for recurrence. In the wild-type group, IASLC grades 2 and 3, pathological stage II/III, ly, and v were identified as independent risk factors for recurrence. Patients with any independent risk factor had a significantly poorer overall survival and a higher CIR compared with those without a risk factor in both the EGFRm and wild-type groups. The IASLC grading system is a valuable prognostic factor for recurrence in patients with lung adenocarcinoma harboring EGFRm.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"451-458"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Myxoid Adrenocortical Carcinoma With 1p Deletion Identified by Whole Exome Sequencing. 全外显子组测序鉴定1例黏液样肾上腺皮质癌伴1p缺失。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI: 10.1111/pin.70045

Naomi Sato, Naomi Oka, Taito Itoh, Yuko Omori, Yuto Yamazaki, Hiroyoshi Suzuki, Ryoko Saito-Koyama, Hiroya Rikimaru, Kanako Sakurai, Sanae Midorikawa, Hideo Saito, Zenei Arihara, Toru Furukawa, Yasuhiro Nakamura

{"title":"A Case of Myxoid Adrenocortical Carcinoma With 1p Deletion Identified by Whole Exome Sequencing.","authors":"Naomi Sato, Naomi Oka, Taito Itoh, Yuko Omori, Yuto Yamazaki, Hiroyoshi Suzuki, Ryoko Saito-Koyama, Hiroya Rikimaru, Kanako Sakurai, Sanae Midorikawa, Hideo Saito, Zenei Arihara, Toru Furukawa, Yasuhiro Nakamura","doi":"10.1111/pin.70045","DOIUrl":"10.1111/pin.70045","url":null,"abstract":"A 57-year-old male underwent an incidental left adrenal tumor resection because of malignancy concerns. The tumor demonstrated a heterogeneous yellowish-white color. Histological features were characterized by nuclear atypia, diffuse growth, sinusoidal invasion, and mucin deposition in most stromal regions, leading to the diagnosis of a myxoid adrenocortical carcinoma (ACC). Whole exome sequencing analysis revealed 1p deletion and other several mutations without TP53 nor CTNNB1 mutations. Following surgery and adjuvant mitotane therapy, the patient showed no recurrence at a 5-year follow-up. Myxoid ACC is an exceedingly rare tumor characterized by mucus deposits in tumor stroma with high malignant potential. Despite the identification of crucial driver gene mutations such as TP53 and CTNNB1 in ACC, the genetic background of the myxoid ACC remains unclear. This case was the first case report of myxoid ACC with a 1p deletion, which was reported to be detected in 67% of ACC and 9% of adenoma but not in hyperplasia, supporting the correlation of this aberration with tumorigenesis. In conclusion, 1p deletion may be relevant to tumorigenesis in myxoid ACC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"471-477"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can We Define a High-Grade Precursor of Small Duct Intrahepatic Cholangiocarcinoma? 我们能确定小管肝内胆管癌的高级别前体吗？

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1111/pin.70042

Shota Kobayashi, Kazuhiro Toriyama, Yasuhiro Oshima, Katsuhiro Masago, Shin Haba, Masataka Okuno, Kiyoko Oshima, Waki Hosoda

引用次数: 0