Pathology International最新文献

Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-27 DOI: 10.1111/pin.70006

Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito

{"title":"Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report.","authors":"Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito","doi":"10.1111/pin.70006","DOIUrl":"https://doi.org/10.1111/pin.70006","url":null,"abstract":"Pulmonary carcinosarcoma is a rare tumor composed of non-small-cell carcinomas and sarcomatous elements, which is poorly differentiated in most cases. We present a case of carcinosarcoma with a well-differentiated carcinomatous component that required a differential diagnosis from tumors derived from teratomas, such as teratocarcinosarcoma. We present a case of a 68-year-old man who visited our hospital for an examination of a 22-mm lung tumor. The patient underwent left S1+2 segmentectomy, and his postoperative course was uneventful. No recurrence was observed in the 21-month postoperative follow-up period. The segmentectomy specimen revealed a yellow-white, well-circumscribed mass. The tumor consisted of well-differentiated squamous and glandular epithelia, and sarcomatous components of immature spindle cells, chondrosarcoma, and rhabdomyosarcoma. The patient was diagnosed with carcinosarcoma. This case included well-differentiated carcinomatous components, and it was necessary to differentiate it from teratocarcinosarcomas. There was no neural component, and without SMARCA4 loss, which is observed in teratocarcinosarcoma, and ruled out teratocarcinosarcoma. Carcinosarcomas are characterized by a biphasic histopathological pattern, making it difficult to accurately diagnose them on biopsy, which only captures a portion of the tumor. The possibility of carcinosarcoma should be considered even when the tumors derived from teratomas are suspected on preoperative biopsy.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-10 DOI: 10.1111/pin.70005

Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita

{"title":"Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers.","authors":"Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita","doi":"10.1111/pin.70005","DOIUrl":"https://doi.org/10.1111/pin.70005","url":null,"abstract":"The reliability of Ki67-labeling index (LI) in core needle biopsy (CNB) of ER+/HER2- invasive breast carcinoma (IBC) and factors affecting the discordance of Ki67-LI between CNB and surgical resection (SR) remain unsolved. We aimed to elucidate factors influencing the discordance of Ki67-LI between CNB and SR to classify ER+/HER2- IBC into luminal A-like (LumA) and luminal B-like (LumB). The cohort included 326 ER+/HER2- IBCs available with Ki67-LI data at both CNB and SR specimens. Survival analysis was performed on 122 patients. Spearman's rank correlation coefficient of Ki67-LI between them was 0.683. The log-rank test showed that patients with ER+/HER2- IBC with ≥ 20% Ki67-LI at CNB (p < 0.001) and SR specimens (p < 0.001) had significantly shorter disease-free survival. In multivariate analysis, a negative PgR (p = 0.002) and > 2 cm pathological tumor size (p < 0.001) had the most significant effect on the discordance of Ki67-LI between CNB and SR at 20% and 30% cutoffs, respectively. Histological grade III had a significant effect on the concordance between them (p = 0.01) at 20% cutoff. Ki67-LI assessment in CNB may be useful for classifying ER+/HER2- IBC into LumA and LumB with caution of some prognostic factors and cutoffs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-05 DOI: 10.1111/pin.70004

Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda

{"title":"A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer.","authors":"Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda","doi":"10.1111/pin.70004","DOIUrl":"https://doi.org/10.1111/pin.70004","url":null,"abstract":"Tumor-infiltrating lymphocyte (TIL) scoring in tumor specimens has gained increasing attention in determining patients who are likely to benefit from immunotherapies. However, the histological evaluation methods of TILs in breast cancer remain limited. This study aimed to assess four components of lymphocytic reaction and overall lymphocytic score (L-score) used in colorectal cancer, investigate its association with clinicopathological factors, and examine the effect of TILs on postoperative mortality using 231 invasive breast cancers without neoadjuvant chemotherapy. Besides L-score, increasing modified L-score lacking peritumoral lymphocytic reaction was significantly associated with aggressive breast cancer phenotypes, including larger invasive size, higher tumor stage, higher Ki-67 labeling index, triple negative and HER2-enriched subtypes, and higher Nottingham histological grade. Importantly, modified L-score status but not L-score or TIL-Working Group (WG) score status was positively correlated with the disease-specific survival rate of the overall patients as well as the patients with luminal type or histological Grade III breast cancers. These results indicated that the modified L-score is a favorable method to comprehensively assess lymphocytic reaction to predict prognosis among patients with breast cancer, even compared with the currently used TIL-WG method, which may possess their potential integration into clinical practice.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichosporon hyphae should be carefully differentiated from Aspergillus hyphae in tissue: A case report.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13514

Masatomo Kimura, Fumiaki Ono, Takaaki Chikugo, Takashi Sugita

引用次数: 0

Clinicopathological study of squamoid morules in nineteen conventional colorectal adenomas.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1111/pin.13516

Dana Perez, Tong Wu, Ritu Bhalla, Zhiyan Fu, Barbara A Centeno, Masoumeh Ghayouri, Kun Jiang, Gregory Lauwers, Yukihiro Nakanishi

{"title":"Clinicopathological study of squamoid morules in nineteen conventional colorectal adenomas.","authors":"Dana Perez, Tong Wu, Ritu Bhalla, Zhiyan Fu, Barbara A Centeno, Masoumeh Ghayouri, Kun Jiang, Gregory Lauwers, Yukihiro Nakanishi","doi":"10.1111/pin.13516","DOIUrl":"10.1111/pin.13516","url":null,"abstract":"Squamoid morules are an intriguing finding rarely seen in colorectal adenomas, mimicking foci of microinvasion or neuroendocrine differentiation. We identified nineteen colorectal adenomas with squamoid morules and collected clinicopathological data. A representative block was chosen for immunohistochemistry. The expression of p40, p63, CK5/6, beta-catenin, synaptophysin, chromogranin, and Ki-67 in squamoid morules were examined immunohistochemically. The nineteen patients comprised fifteen males (79%) and four females (21%) ranging in age from 45 to 85 years (average: 59.4 years old). Fourteen adenomas were tubulovillous adenomas (average: 3.4 cm, ranging 1.0 to 6.0 cm) and five were tubular adenomas (average: 2.6 cm, ranging 1.6 to 3.0 cm). All foci of squamoid morules showed beta-catenin nuclear positivity and CK5/6 expression. Squamoid morules were focally positive for p63 in four adenomas and focally positive for p40 in two adenomas. In two adenomas squamoid morules are focally positive for synaptophysin, and in one adenoma chromogranin was focally positive. In all nineteen adenomas squamoid morules were negative for Ki-67. Squamoid morules are characterized by strong male predominance, large adenoma size, beta-catenin nuclear positivity, CK5/6 expression, and no Ki-67 expression. Beta-catenin nuclear expression is helpful in distinguishing squamoid morules from foci of microinvasion and neuroendocrine differentiation.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"145-150"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1111/pin.70001

Marie Kato-Shinomiya, Hirokazu Sugino, Lei Wang, Yusuke Saito, Jintao He, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Mishie Tanino, Jian Ping Gong, Masumi Tsuda, Shinya Tanaka

{"title":"SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells.","authors":"Marie Kato-Shinomiya, Hirokazu Sugino, Lei Wang, Yusuke Saito, Jintao He, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Mishie Tanino, Jian Ping Gong, Masumi Tsuda, Shinya Tanaka","doi":"10.1111/pin.70001","DOIUrl":"10.1111/pin.70001","url":null,"abstract":"Mesothelioma is a highly aggressive tumor affecting an increasing number of patients worldwide. Owing to the poor clinical outcomes associated with current therapies, the development of novel therapies that target cancer stem cells (CSCs) is desirable. Here, we examined the applicability of our previously established hydrogel-based rapid CSC generation method to human mesothelioma cell lines and further analyzed the characteristics of the induced mesothelioma stem cell (MesoSC) -like cells. Human mesothelioma cell lines cultured on hydrogels presented increased expression of pan-stem cell markers and acquired spheroid formation and early tumorigenicity, suggesting that MesoSC-like cells are highly malignant. Microarray analysis demonstrated that the expression of SLC13A5, a citrate transporter involved in TCA cycle, was significantly induced in the resulting MesoSC-like cells. The overexpression of SLC13A5 resulted in a metabolic shift toward oxidative phosphorylation, increased phosphorylation of ERK and YAP, and increased SOX2 expression, leading to increased cisplatin resistance. scRNA-seq database analysis revealed that clinical mesothelioma samples contained a small number of SLC13A5-expressing cells. Our findings suggest that the hydrogel-based CSC generation method is also effective for human mesothelioma cells and that SLC13A5 may contribute to MesoSC survival. The new properties of MesoSCs revealed in this study may provide clues for establishing future treatments.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"151-165"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research. 探索前列腺癌化学预防的实验模型：氧化应激是转化研究的关键途径。

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1111/pin.13509

Aya Naiki-Ito, Taku Naiki, Satoru Takahashi

{"title":"Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research.","authors":"Aya Naiki-Ito, Taku Naiki, Satoru Takahashi","doi":"10.1111/pin.13509","DOIUrl":"10.1111/pin.13509","url":null,"abstract":"Prostate cancer (PCa) is the second most common cancer in men globally. Its growth is driven by oxidative stress associated with inflammation, aging, and environmental factors, including diet and lifestyle. These factors contribute to multiple stages of PCa progression, including progression to castration-resistant prostate cancer (CRPC). Therefore, oxidative stress represents an intriguing target for PCa chemoprevention and treatment. In vivo experimental models are crucial for understanding the mechanisms of PCa development, validating chemopreventive and therapeutic approaches, and translating preclinical results into clinical applications. We established a transgenic rat for adenocarcinoma of the prostate (TRAP) model, a transgenic rat that efficiently develops androgen-dependent adenocarcinoma, pathologically and biologically mimicking human PCa progression, to clarify the mechanisms of tumor progression, including the involvement of oxidative stress, and established a system for screening the chemopreventive effects of agents against PCa. Additionally, we derived a CRPC model from the TRAP model and developed a distant metastasis model, providing a comprehensive multistage rat model of prostate carcinogenesis. This review presents findings on the molecular mechanisms of PCa and the chemopreventive effects of natural compounds with antioxidant properties, such as polyphenols. We additionally described the potential for repositioning existing drugs with antiandrogenic activity for PCa chemoprevention.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"131-144"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Primary Cutaneous T-Follicular Helper Cell Lymphoma, Follicular-Type.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1111/pin.70003

Reiji Muto, Hiroaki Miyoshi, Toshihiko Murayama, Koji Makino, Koichi Ohshima

{"title":"A Case of Primary Cutaneous T-Follicular Helper Cell Lymphoma, Follicular-Type.","authors":"Reiji Muto, Hiroaki Miyoshi, Toshihiko Murayama, Koji Makino, Koichi Ohshima","doi":"10.1111/pin.70003","DOIUrl":"10.1111/pin.70003","url":null,"abstract":"This is a case of primary cutaneous T-follicular helper cell lymphoma, follicular-type. A 99-year-old woman was detected with cutaneous mass located in left greater trochanter area and buttock, which was suspected to be malignant lymphoma. Computed tomography revealed few regional lymph node enlargement. Skin biopsy was performed for diagnosis. Pathologically, diffuse and dense proliferation of medium-sized atypical lymphocytes was observed proliferating with a vague nodular pattern. The immunohistochemical analysis presented that atypical lymphocytes composing vague nodular lesion were positive for CD3, CD4, PD-1, ICOS, BCL6, and CXCL13. Additionally, diffuse medium-sized B-cell proliferation was also observed. The monoclonality of T-cell receptor-gamma and IgVH was confirmed by polymerase chain reaction. Here we described a primary cutaneous case of FTCL. In the 5th edition of the WHO classification, TFH lymphoma is limited to lymph node and there is no consensus regarding the management of extranodal TFH lymphoma. Further accumulation of extranodal counterpart of the cases and clinicopathological examination of extranodal and nodal lesions is desired.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"166-170"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological predictor of progressive pulmonary fibrosis.

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.1111/pin.13511

Ae Ri Ahn, Kyoung Min Kim, Ho Sung Park, Kyu Yun Jang, Woo Sung Moon, Myoung Ja Chung

引用次数: 0

Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer.

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-12 DOI: 10.1111/pin.70002

Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose

{"title":"Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer.","authors":"Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose","doi":"10.1111/pin.70002","DOIUrl":"https://doi.org/10.1111/pin.70002","url":null,"abstract":"Urinary bladder cancer includes non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). While patients with NMIBC have a better prognosis, NMIBC often recurs, requiring long-term surveillance and repeated treatments. Intravesical Bacillus Calmette-Guérin (BCG) therapy is standard for high-grade or recurrent NMIBC; however, 30%-50% of patients failed to respond, and the mechanisms of resistance remain unclear. To identify predictive biomarkers for response to intravesical BCG therapy, we analyzed NANOG and Histone deacetylase 1 (HDAC1) expression in 90 bladder cancer specimens from NMIBC patients treated with BCG therapy using immunohistochemistry. The correlation between NANOG and HDAC1 expression and clinical outcomes, including response to BCG therapy, was assessed. High-grade NMIBC cases showed significantly higher expression of NANOG and HDAC1 compared to low-grade cases (p < 0.05). Additionally, elevated NANOG expression in combination with HDAC1, was associated with poor response to BCG therapy and decreased lymphocyte infiltration in the tumor-microenvironment. NANOG is suggested to directly increases HDAC1 expression, which could suppress lymphocyte infiltration in the tumor microenvironment by altering immune-related gene expression. These findings suggest that the NANOG/HDAC1 axis plays a key role in predicting resistance to intravesical BCG therapy in NMIBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0