Pathology International最新文献

Trichosporon hyphae should be carefully differentiated from Aspergillus hyphae in tissue: A case report.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13514

Masatomo Kimura, Fumiaki Ono, Takaaki Chikugo, Takashi Sugita

引用次数: 0

Myxoid spindle cell tumor with EWSR1-CREM fusion mimicking papillary adenoma of the lung.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13517

Yurie Okayama, Shin Ishizawa, Akane Aikawa, Yuko Nakanishi, Akio Uchiyama, Tomohiko Takahashi, Yasushi Yatabe

引用次数: 0

Atypical choroid plexus papilloma arising in a mature ovarian teratoma, a case report.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13513

Brandon Gehris, Songlin Zhang, Xiaohong Iris Wang

引用次数: 0

Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13507

Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka

{"title":"Spontaneous Transformation from Lung Adenocarcinoma to MYC-amplified Large Cell Neuroendocrine Carcinoma.","authors":"Tetsuhiro Yamakado, Hanako Sato-Yazawa, Jun Ishii, Korehito Kashiwagi, Taichi Kimura, Zen-Ichi Tanei, Takuya Yazawa, Yusuke Ishida, Shinya Tanaka","doi":"10.1111/pin.13507","DOIUrl":"https://doi.org/10.1111/pin.13507","url":null,"abstract":"Recent studies suggest that lung adenocarcinoma cells are closely associated with the tumorigenesis of large-cell neuroendocrine carcinoma via cellular transformation. However, morphological evidence, along with genetic abnormalities before, during, and after transformation, is quite limited. We present here a case of combined large-cell neuroendocrine carcinoma and adenocarcinoma exhibiting acinar and solid patterns. Adenocarcinoma cells with abundant mucin, exhibiting positivity for both napsin-A and neuroendocrine markers, were partially found in the acinar adenocarcinoma component and extensively observed in the solid adenocarcinoma component. Next-generation sequencing using extracted genomic DNA from the three components revealed homozygous TP53 (missense) and STK11 (nonsense) mutations in all three components, suggesting monoclonal origin. Furthermore, MYC gene amplification, recently presumed to be a pivotal driver in neuroendocrine transformation, was observed in both the solid adenocarcinoma and large-cell neuroendocrine carcinoma components. These genetic findings corresponded to pre- and post-transformation morphology, providing compelling evidence that some kinds of adenocarcinomas may serve as a precursor of large-cell neuroendocrine carcinoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of human papillomavirus (HPV) association on the prognosis of pyriform sinus carcinoma: A retrospective cohort study. 人乳头瘤病毒（HPV）关联对梨状窦癌预后的影响：一项回顾性队列研究。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-15 DOI: 10.1111/pin.13512

Shunsuke Koga, Wei Du, Robert M Brody, Kumarasen Cooper

引用次数: 0

Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research. 探索前列腺癌化学预防的实验模型：氧化应激是转化研究的关键途径。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-14 DOI: 10.1111/pin.13509

Aya Naiki-Ito, Taku Naiki, Satoru Takahashi

{"title":"Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research.","authors":"Aya Naiki-Ito, Taku Naiki, Satoru Takahashi","doi":"10.1111/pin.13509","DOIUrl":"https://doi.org/10.1111/pin.13509","url":null,"abstract":"Prostate cancer (PCa) is the second most common cancer in men globally. Its growth is driven by oxidative stress associated with inflammation, aging, and environmental factors, including diet and lifestyle. These factors contribute to multiple stages of PCa progression, including progression to castration-resistant prostate cancer (CRPC). Therefore, oxidative stress represents an intriguing target for PCa chemoprevention and treatment. In vivo experimental models are crucial for understanding the mechanisms of PCa development, validating chemopreventive and therapeutic approaches, and translating preclinical results into clinical applications. We established a transgenic rat for adenocarcinoma of the prostate (TRAP) model, a transgenic rat that efficiently develops androgen-dependent adenocarcinoma, pathologically and biologically mimicking human PCa progression, to clarify the mechanisms of tumor progression, including the involvement of oxidative stress, and established a system for screening the chemopreventive effects of agents against PCa. Additionally, we derived a CRPC model from the TRAP model and developed a distant metastasis model, providing a comprehensive multistage rat model of prostate carcinogenesis. This review presents findings on the molecular mechanisms of PCa and the chemopreventive effects of natural compounds with antioxidant properties, such as polyphenols. We additionally described the potential for repositioning existing drugs with antiandrogenic activity for PCa chemoprevention.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary pleomorphic carcinoma: A rare case showing arterial carcinomatosis mimicking pulmonary artery intimal sarcoma. 肺动脉多形性癌：一例罕见的类似肺动脉内膜肉瘤的动脉癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-09 DOI: 10.1111/pin.13508

Ikumi Kitazono, Miki Murakami, Aya Takeda, Hirotsugu Noguchi, Takashi Tasaki, Mari Kirishima, Michiyo Higashi, Kazuhiro Ueda, Akihide Tanimoto

引用次数: 0

Two rare ALK fusion variants overlooked by multiplexed gene testing: The crucial role of immunohistochemistry in ensuring comprehensive molecular testing. 两种罕见的ALK融合变异被多重基因检测忽视：免疫组织化学在确保全面的分子检测中的关键作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-07 DOI: 10.1111/pin.13506

Hironori Ninomiya, Yuki Togashi, Keisuke Sugita, Kengo Takeuchi

引用次数: 0

Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue. 间充质间质细胞超氧化物歧化酶2缺乏可引起交感神经断神经和棕色脂肪组织功能损伤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-06 DOI: 10.1111/pin.13503

Yuya Urano, Shinji Mii, Shun Asai, Nobutoshi Esaki, Ryota Ando, Yukihiro Shiraki, Tadashi Iida, Katsuhiro Kato, Mika Hori, Yoshitaka Hayashi, Takahiko Shimizu, Atsushi Enomoto

{"title":"Superoxide dismutase 2 deficiency in mesenchymal stromal cells induces sympathetic denervation and functional impairment of brown adipose tissue.","authors":"Yuya Urano, Shinji Mii, Shun Asai, Nobutoshi Esaki, Ryota Ando, Yukihiro Shiraki, Tadashi Iida, Katsuhiro Kato, Mika Hori, Yoshitaka Hayashi, Takahiko Shimizu, Atsushi Enomoto","doi":"10.1111/pin.13503","DOIUrl":"https://doi.org/10.1111/pin.13503","url":null,"abstract":"Brown adipose tissue (BAT) is an energy-consuming organ, and its functional dysregulation contributes to the development of metabolic diseases and obesity. BAT function is regulated by the sympathetic nervous system but declines with age, which is partly caused by reduced sympathetic nerve fibers innervating BAT. Thus far, the role of mesenchymal stromal/stem cells in age-related BAT dysfunction remains unknown. Here, we show that BAT dysfunction may be induced by a defect in the antioxidant capacity of stromal cells that localize in and around the nerve fibers (perineurial cells) of BAT. These cells express Meflin, a marker of mesenchymal stromal/stem cells. Specific deletion of the antioxidant enzyme superoxide dismutase 2 in Meflin-lineage cells caused sympathetic denervation and whitening of BAT and its functional impairment, as exemplified by a decline in the fat oxidation rate during the daytime. This phenotype was accompanied by overexpression of the neurorepulsive factor semaphorin 3A in perineurial cells. Notably, Meflin-deficient mice exhibited resistance to doxorubicin-induced BAT dysfunction. These results highlight the role of Meflin+ stromal cells, including perineurial cells, in maintaining BAT function and suggest that targeting BAT stromal cells provides a new avenue for improving BAT function.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer. 食管癌中核梭杆菌定位/分布的组织病理学研究。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-06 DOI: 10.1111/pin.13505

Iku Sasaki-Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki

{"title":"Histopathological study of the localization/distribution of Fusobacterium nucleatum in esophageal cancer.","authors":"Iku Sasaki-Higashimoto, Fumiyoshi Fujishima, Hirotaka Ishida, Yusuke Taniyama, Yohei Ozawa, Tomohiro Nakamura, Naoki Nakaya, Chiaki Sato, Hiroshi Okamoto, Junichi Tsunokake, Atsushi Kunimitsu, Takeru Mozumi, Takashi Kamei, Takashi Suzuki","doi":"10.1111/pin.13505","DOIUrl":"https://doi.org/10.1111/pin.13505","url":null,"abstract":"Fusobacterium nucleatum is implicated in esophageal cancer; however, its distribution in esophageal cancer tissues remains unknown. This study aimed to clarify the presence and distribution of F. nucleatum in esophageal cancer tissues using fluorescence in situ hybridization (FISH). Tissues collected from 70 patients with esophageal squamous cell carcinoma were examined using FISH. Corresponding normal epithelium and metastatic lymph nodes were assessed. F. nucleatum was identified more frequently in esophageal cancer tissues than in the normal epithelium. F. nucleatum also showed significant correlation with factors associated with tumor progression, such as pT factor and tumor size. As tumor progression advanced, the area occupied by F. nucleatum gradually became larger. F. nucleatum positivity was observed around the deep edge of the tumor nest (border-dense type) or identified diffusely in the tumor nest (diffuse distributed type). Furthermore, F. nucleatum was observed in metastatic lymph nodes, lesions of venous invasion, and walls of veins in normal epithelium. In conclusion, we visualized F. nucleatum using FISH and identified different distribution patterns of F. nucleatum, highlighting the spot density of its presence in tumor tissues. Recognizing this quantitative change is pivotal for establishing F. nucleatum as a reliable biomarker.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0