Pathology International最新文献_第2页

Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations. BRAF和NRAS突变的软组织肿瘤与ntrk重排梭形细胞肿瘤具有共同的特征：一例报告扩大了激酶基因改变的梭形细胞肿瘤的谱。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1111/pin.13499

Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi

{"title":"Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.","authors":"Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi","doi":"10.1111/pin.13499","DOIUrl":"10.1111/pin.13499","url":null,"abstract":"NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"40-45"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratin-derived amyloid deposition associated with silicone granuloma in an older adult: Comprehensive analysis using immunohistochemistry, proteomics, and a literature review. 与一名老年人硅肉芽肿相关的角蛋白源性淀粉样沉积：利用免疫组化、蛋白质组学和文献综述进行综合分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1111/pin.13490

Shojiro Ichimata, Tomochika Kuroda, Tsuneaki Yoshinaga, Mitsuto Sato, Nagaaki Katoh, Fuyuki Kametani, Suzuho Onagi, Masahide Yazaki, Yoshiki Sekijima, Shin Ishizawa

引用次数: 0

Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report. 前纵隔成熟囊性畸胎瘤引发的分泌性腺癌：病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1111/pin.13495

Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki

{"title":"Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report.","authors":"Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki","doi":"10.1111/pin.13495","DOIUrl":"10.1111/pin.13495","url":null,"abstract":"Primary mediastinal apocrine adenocarcinoma is extremely rare, with only one case reported to date. Here, we report a surgical case of primary mediastinal apocrine adenocarcinoma. An anterior mediastinal cystic tumor with calcification was identified on chest computed tomography scan in a 51-year-old female patient undergoing maintenance hemodialysis. The tumor was 19 mm in size, did not invade the adjacent organs or show distant metastases, and was surgically removed. Microscopic examination revealed that the tumor cells exhibited cribriform or solid proliferation patterns with thick fibrous capsules. The tumor cells had an abundant eosinophilic cytoplasm, and decapitation secretion was noted. Immunohistochemistry revealed positivity for GCDFP-15 and androgen receptors, with Ki-67 positivity at 10%. The cyst wall exhibited extensive fibrosis and keratinized material, with bone and bronchial glands identified at the cyst periphery; the tumor cells were contiguous with those structures. The patient was diagnosed with apocrine adenocarcinoma arising from a mature cystic teratoma. The patient has maintained a recurrence-free status without adjuvant therapy for 6 years after surgery. This case presents a small primary mediastinal apocrine adenocarcinoma that achieved remarkable long-term survival.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"34-39"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging. 基于多光子激发成像非标记分析的光学组织病理学。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13498

Takahiro Matsui

{"title":"Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.","authors":"Takahiro Matsui","doi":"10.1111/pin.13498","DOIUrl":"10.1111/pin.13498","url":null,"abstract":"Histopathological diagnosis is the definitive method for the evaluation of disease status; however, some problems need to be solved, such as invasiveness, time consumption, and difficulty in three-dimensional observation. To overcome these problems, a novel observation method, distinct from conventional histology, using tissue sections and glass slides is desirable. Fluorescence imaging of human tissues with multiphoton excitation imaging (MpEI), which was originally used for intravital imaging in biological research, is a promising method. Label-free MpEI, which requires only near-infrared excitation, can construct images with autofluorescent signals from fresh tissues, as well as nonlinear optical phenomena. It is possible to perform real-time three-dimensional imaging of human tissues without any tissue removal, fixation, or staining. This method has been reported to be useful for histopathological classification in multiple organs and tissues. Moreover, it is very compatible with quantitative image analyses, including artificial intelligence. Based on these characteristics, label-free MpEI has sufficient potential for clinical applications such as in endoscopy and intraoperative rapid diagnosis. The clinical application of label-free MpEI will bring changes not only to histopathology examination but also the clinical bedside and will contribute to the further development of histopathology.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian mucinous cystic tumor with an overwhelming fundic gland differentiation. 卵巢粘液性囊肿伴有压迫性底腺分化。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1111/pin.13493

Satoe Numakura, Yuko Sasajima, Teppei Morikawa, Takayuki Ichinose, Kazunori Nagasaka, Masahiro Kato, Hiroshi Uozaki

引用次数: 0

Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation. 中枢神经系统原发性大b细胞淋巴瘤：基于临床、病理和分子评价的cd5阳性病例的重新评估

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13496

Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura

{"title":"Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation.","authors":"Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura","doi":"10.1111/pin.13496","DOIUrl":"10.1111/pin.13496","url":null,"abstract":"CD5 expression is seen in 5%-10% of de novo diffuse large B-cell lymphomas (DLBCLs). Primary large B-cell lymphoma of the central nervous system (PCNS-LBCL) also exhibits CD5 expression in a minority of cases, however, clinicopathological and molecular features remain largely unclarified. Here we present the clinical, molecular, and pathological features of 11 CD5-positive (+) PCNS-LBCL cases, occupying 6.7% of all 165 PCNS-LBCLs diagnosed in our institutions. While CD5+ systemic DLBCL has been recognized as a distinctive subgroup showing an aggressive clinical course, no obvious differences were found between CD5+ and CD5-negative subgroups among the present CNS patients clinically. MYD88 p.L265P and CD79B p.Y196 mutations were detected in eight (73%) and seven (64%) cases, respectively, supporting previous reports. Notably, the microenvironmental immune cells were universally PD-L1/CD274-positive, and the higher levels tended to present favorable overall survival, as already evidenced in the PCNS-LBCL series. In contrast, neoplastic PD-L1/CD274 expression was undetectable in all cases. Indeed, no structural variations or copy number alterations involving PD-1 ligands were detected by targeted-capture sequencing and fluorescence in situ hybridization. While further studies are warranted, we may have confirmed similarity between PCNS-LBCLs and intravascular large B-cell lymphomas from a molecular standpoint.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"11-20"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High levels of REV7 expression are associated with poor prognosis and chemoresistance in gastric adenocarcinoma. 在胃腺癌中，高水平的REV7表达与不良预后和化疗耐药有关。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-31 DOI: 10.1111/pin.13504

Yurika Kesen, Masaaki Ichinoe, Shoko Hayashi, Atsuko Umezawa, Yoshiko Numata, Taro Kogami, Masahiro Matsushita, Itaru Sanoyama, Akiyoshi Hoshino, Yasutaka Sakurai, Takuya Kato, Yoshiki Murakumo

{"title":"High levels of REV7 expression are associated with poor prognosis and chemoresistance in gastric adenocarcinoma.","authors":"Yurika Kesen, Masaaki Ichinoe, Shoko Hayashi, Atsuko Umezawa, Yoshiko Numata, Taro Kogami, Masahiro Matsushita, Itaru Sanoyama, Akiyoshi Hoshino, Yasutaka Sakurai, Takuya Kato, Yoshiki Murakumo","doi":"10.1111/pin.13504","DOIUrl":"10.1111/pin.13504","url":null,"abstract":"REV7 is a multifunctional protein essential for promoting cellular tolerance to DNA damage. REV7 expression is associated with disease progression and prognosis in several human malignant tumors. This study aimed to evaluate the clinical and biological significance of REV7 in gastric adenocarcinoma (GAD). REV7 expression in 167 resected GADs was immunohistochemically assessed and examined the association with clinicopathological features. Positive expression of REV7 was significantly associated with tumor undifferentiation (p < 0.001), lymphatic invasion (p = 0.035), recurrence (p = 0.042), and mortality (p = 0.031). The Kaplan-Meier curves with log-rank tests revealed significantly poorer progression-free survival (p = 0.049), overall survival (p = 0.037), and post-progression survival (p = 0.038) in the REV7-positive group. Multivariate analysis using the Cox proportional hazard model identified REV7 as an independent prognostic factor for overall survival (p = 0.028). REV7-depleted GAD cell lines demonstrated enhanced sensitivity to cisplatin compared with control cells. Additionally, the expression levels of REV7 in residual tumors from surgical specimens of patients who received preoperative chemotherapy were higher than those in samples without chemotherapy (p = 0.029), suggesting that REV7-positive tumors are chemoresistant. These results indicate that REV7 is a predictive biomarker for the prognosis and chemosensitivity of GAD.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"21-33"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 DOI: 10.1111/pin.13487

引用次数: 0

Roles of osteoclasts in pathological conditions. 破骨细胞在病理状态中的作用

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-20 DOI: 10.1111/pin.13500

Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa

{"title":"Roles of osteoclasts in pathological conditions.","authors":"Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa","doi":"10.1111/pin.13500","DOIUrl":"https://doi.org/10.1111/pin.13500","url":null,"abstract":"Bone is a unique organ crucial for locomotion, mineral metabolism, and hematopoiesis. It maintains homeostasis through a balance between bone formation by osteoblasts and bone resorption by osteoclasts, which is regulated by the basic multicellular unit (BMU). Abnormal bone metabolism arises from an imbalance in the BMU. Osteoclasts, derived from the monocyte-macrophage lineage, are regulated by the RANKL-RANK-OPG system, which is a key factor in osteoclast differentiation. RANKL activates osteoclasts through its receptor RANK, while OPG acts as a decoy receptor that inhibits RANKL. In trabecular bone, high turnover involves rapid bone formation and resorption, influenced by conditions such as malignancy and inflammatory cytokines that increase RANKL expression. Cortical bone remodeling, regulated by aged osteocytes expressing RANKL, is less understood, despite ongoing research into how Rett syndrome, characterized by MeCP2 abnormalities, affects RANKL expression. Balancing trabecular and cortical bone involves mechanisms that preserve cortical bone, despite overall bone mass reduction due to aging or oxidative stress. Research into genes like sFRP4, which modulates bone mass, highlights the complex regulation by BMUs. The roles of the RANKL-RANK-OPG system extend beyond bone, affecting processes such as aortic valve formation and temperature regulation, which highlight the interconnected nature of biological research.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy. 腱鞘炎伴炎性钙化--扫描电子显微镜和能量色散 X 射线光谱分析。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-13 DOI: 10.1111/pin.13502

Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi

{"title":"Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy.","authors":"Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi","doi":"10.1111/pin.13502","DOIUrl":"https://doi.org/10.1111/pin.13502","url":null,"abstract":"Tenosynovitis with psammomatous calcification (TPC) is an extremely rare condition. It was first described as a characteristic subtype of idiopathic calcifying tenosynovitis, with only 40 cases reported to date. Here, we present a case of TPC affecting a female patient in her late teens, with no relevant medical history. She presented with discomfort and pain in the right first toe. A 10-mm mushroom-like calcified mass was observed in the metatarsophalangeal joint on radiographs. The surgical specimen revealed chronic synovitis with calcification. Numerous psammomatous bodies are observed in the synovium, often with granulomatous reactions. After removal of the mass, no recurrence has been observed for 5 years. Although the etiology of TPC has been suggested to be related to repetitive trauma to the tendon or peritendinous soft tissue, the composition and mechanism of calcification remain unclear because of its rarity. In this report, we also discuss the calcification mechanism in TPC, supported by scanning electron microscopy and energy-dispersive x-ray spectroscopy findings.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0