Pathology International最新文献_第2页

A Novel Tight Junction-Nuclear Receptor Signaling Pathway Regulating Cancer Progression. 一种调节癌症进展的新型紧密连接-核受体信号通路。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1111/pin.70040

Kotaro Sugimoto, Hideki Chiba

引用次数: 0

Primary Pulmonary Epithelial-Myoepithelial Carcinoma With Prominent Reactive Pneumocytes: Clinicopathological Insights Into a Rare Case and Literature Review. 原发性肺上皮-肌上皮癌伴显著反应性肺细胞：一例罕见病例的临床病理分析及文献复习。

IF 3.4 4区医学

Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI: 10.1111/pin.70046

Asuka Okada, Sae Hato, Motohiro Nishimura, Maiko Takeda, Tomomi Fujii, Chiho Ohbayashi

引用次数: 0

Spatially and Clonally Multiple B-/Plasma Cell Proliferations in T Follicular Helper Cell Lymphoma: A Case Report. T滤泡辅助细胞淋巴瘤的空间和克隆多发B /浆细胞增殖：1例报告。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-12 DOI: 10.1111/pin.70043

Yuka Yokota, Naoki Oishi, Kazunari Kasai, Masataka Kawai, Ippei Tahara, Tomohiro Inoue, Yuma Sakamoto, Megumi Koshiish-Yamada, Keita Kirito, Tetsuo Kondo

{"title":"Spatially and Clonally Multiple B-/Plasma Cell Proliferations in T Follicular Helper Cell Lymphoma: A Case Report.","authors":"Yuka Yokota, Naoki Oishi, Kazunari Kasai, Masataka Kawai, Ippei Tahara, Tomohiro Inoue, Yuma Sakamoto, Megumi Koshiish-Yamada, Keita Kirito, Tetsuo Kondo","doi":"10.1111/pin.70043","DOIUrl":"https://doi.org/10.1111/pin.70043","url":null,"abstract":"T follicular helper cell lymphoma (TFHL) is a systemic T-cell lymphoma with a phenotype reminiscent of TFH cells and frequent RHOA p.G17V mutation. Here, we report a case of TFHL with spatially multiple and clonally independent B-/plasma cell proliferations (B/PC-Ps), which posed diagnostic difficulties. An 87-year-old female presented with a skin rash, and a skin biopsy from the chest was initially diagnosed as low-grade B-cell lymphoma with plasmacytic differentiation. Three months after rituximab monotherapy, bilateral pleural effusions developed. Cytology of the pleural effusion revealed abnormal lymphocytes and plasma cells. The abnormal T-cells were positive for CD3, CD4, CD10, and PD1, while the neoplastic plasma cells showed kappa-predominant light-chain restriction. Additional cutaneous biopsies from the left forearm and upper arm revealed Epstein-Barr virus-positive and -negative B/PC-Ps, respectively. Polymerase chain reaction identified RHOA p.G17V and the same monoclonal rearrangement of T-cell receptor gamma gene (TRG) in all the four specimens. In addition, three cutaneous lesions showed distinct monoclonal immunoglobulin heavy chain gene (IGH) rearrangements. This case demonstrates phenotypic and clonal diversity of monoclonal B/PC-Ps in TFHL, which can obscure the neoplastic TFH proliferation. In such cases, careful clinicopathological correlation and the integration of immunophenotypic and genetic analyses may aid in the diagnosis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Landscape of Cancer Metabolism as a Therapeutic Target. 肿瘤代谢作为治疗靶点的前景。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1111/pin.70034

Kenji Ohshima

{"title":"The Landscape of Cancer Metabolism as a Therapeutic Target.","authors":"Kenji Ohshima","doi":"10.1111/pin.70034","DOIUrl":"10.1111/pin.70034","url":null,"abstract":"Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a promising therapeutic target. Since the clinical application of folate antimetabolites in the 1940s, numerous therapeutic strategies targeting cancer metabolism have been developed. In recent years, advancements in technologies such as metabolome analysis have facilitated the development of agents that more specifically target cancer cell metabolism. However, these newly developed agents often face challenges in demonstrating efficacy as monotherapies in clinical trials. Nevertheless, combination therapies, designed based on precise mechanistic insights and incorporating agents such as immune-checkpoint and signaling-pathway inhibitors, have shown promising efficacy. This review provides an overview of the current landscape of therapeutic strategies targeting cancer metabolism, with a particular focus on approaches targeting amino acid, fatty acid, and glucose metabolism in cancer cells.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"387-402"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the Size of Perineural Cancer Invasion on Prostate Needle Core Biopsy Have a Clinical Impact? 前列腺穿刺活检对神经周围癌浸润的大小有临床影响吗？

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-07-24 DOI: 10.1111/pin.70039

Hangchuan Shi, Ying Wang, Hiroshi Miyamoto

引用次数: 0

Prostatic Stromal Sarcoma With SMARCA4 Mutation: A Case Report. 前列腺基质肉瘤伴SMARCA4突变1例

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.1111/pin.70041

Kenjiro Kato, Hiromi Kanno-Okada, Ryuji Matsumoto, Shin Ariga, Kanako Hagio, Utano Tomaru, Takashige Abe, Toyonori Tsuzuki, Yoshihiro Matsuno, Shinya Tanaka

引用次数: 0

Increased Expression of AXL and c-MET in High-Grade Clear Cell Renal Cell Carcinoma and Its Association With VEGFR-TKI Treatment and PD-L1 Expression. AXL和c-MET在高级别透明细胞肾细胞癌中的表达升高及其与VEGFR-TKI治疗和PD-L1表达的关系

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-02 DOI: 10.1111/pin.70030

Shuji Mikami, Ryuichi Mizuno, Nobuyuki Tanaka, Kyohei Hakozaki, Kimiharu Takamatsu, Mototsugu Oya

{"title":"Increased Expression of AXL and c-MET in High-Grade Clear Cell Renal Cell Carcinoma and Its Association With VEGFR-TKI Treatment and PD-L1 Expression.","authors":"Shuji Mikami, Ryuichi Mizuno, Nobuyuki Tanaka, Kyohei Hakozaki, Kimiharu Takamatsu, Mototsugu Oya","doi":"10.1111/pin.70030","DOIUrl":"10.1111/pin.70030","url":null,"abstract":"Cabozantinib, a newly developed vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI), is an effective treatment for advanced renal cell carcinoma (RCC). However, the molecular mechanisms responsible for the superior effectiveness of cabozantinib to other drugs remain unclear. Since cabozantinib inhibits AXL and c-MET in addition to VEGFR, the expression of these molecules was immunohistologically examined in 110 cases of primary clear cell RCC (ccRCC) and eight of sunitinib (VEGFR-TKI)-treated primary ccRCC. AXL expression correlated with the primary tumor stage, while c-MET expression correlated with distant metastasis, the histological grade, and overall survival. Furthermore, the number of programmed death-ligand 1 (PD-L1)-positive tumor-infiltrating immune cells was higher in ccRCC tissues with high c-MET expression than in those with low c-MET expression. The expression of AXL and c-MET was higher in sunitinib-treated ccRCC tissues than in untreated tissues. These results suggest that AXL and c-MET play important roles in the progression of ccRCC and resistance to sunitinib. Furthermore, c-MET may modify the immune microenvironment by inducing PD-L1 expression in immune cells within RCC tissues. These molecular pathways may be related to responses to cabozantinib.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"403-413"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unexpected Autopsy Case of Placental Transmogrification of the Lung With Lipomatous Change With Detailed Immunohistochemical Analysis. 肺胎盘变形伴脂肪瘤改变的意外尸检病例及详细的免疫组织化学分析。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1111/pin.70031

Ryo Kaimori, Haruto Nishida, Riko Kubota Furukawa, Kazuhiro Kawamura, Mari Tamura, Kohji Kuroki, Shinji Yano, Kumi Murata, Tsutomu Daa, Shinjiro Mori

{"title":"Unexpected Autopsy Case of Placental Transmogrification of the Lung With Lipomatous Change With Detailed Immunohistochemical Analysis.","authors":"Ryo Kaimori, Haruto Nishida, Riko Kubota Furukawa, Kazuhiro Kawamura, Mari Tamura, Kohji Kuroki, Shinji Yano, Kumi Murata, Tsutomu Daa, Shinjiro Mori","doi":"10.1111/pin.70031","DOIUrl":"10.1111/pin.70031","url":null,"abstract":"Placental transmogrification of the lung (PTL) is a rare cystic lesion characterized by a distinctive microscopic architecture resembling placental villi. Although its etiology remains unclear, PTL is frequently observed with emphysema, suggesting a potential association between these conditions. However, the precise nature of this relationship remains ambiguous, and whether PTL causes or results from emphysema remains unclear. This report presents an incidental finding of PTL without macroscopic emphysematous changes with detailed immunohistochemical and ultrastructural analysis. A 58-year-old man died from aspiration pneumonia due to methanol poisoning. Autopsy revealed pyothorax in the right lung cavity and hemorrhage in the bilateral putamen. Although the left lung showed no severe inflammatory changes, a white-yellowish granular lesion was observed. Histopathologically, the lesion demonstrated villi-like structures with interstitial adipocyte infiltration, without evidence of hamartomatous component, such as cartilage or smooth muscle. Thus, the lesion was diagnosed as PTL with lipomatous change. PTL is typically associated with emphysematous/cystic lesions and is often considered reactive due to these. Herein, the lesion was surrounded by microscopic emphysema, suggesting an early-stage PTL that may have contributed to the development of emphysematous changes. This report describes the PTL with detailed immunohistochemical analysis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"425-430"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine Mesenchymal Neoplasm With a Novel CDC42::PLAG1 Fusion. 子宫间质肿瘤与新型CDC42::PLAG1融合。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI: 10.1111/pin.70035

Pranav Dorwal, Diarmid Foulis, Jing Jing Li, Michael Burling, Lyndal Anderson

引用次数: 0

High Frequency of RhoGAP Fusion and Muscularis Mucosae Invasion in pT1a Gastric Adenocarcinoma Harboring Lymph Node Metastasis. 伴有淋巴结转移的pT1a型胃腺癌RhoGAP融合及黏膜肌层浸润的高频率研究

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1111/pin.70032

Chiina Hata, Hiroto Noda, Kaoru Nakano, Seiji Sakata, Kazuma Moriya, Satoko Baba, Toshiaki Hirasawa, Manabu Takamatsu, Emiko Sugawara, Noriko Yamamoto, Souya Nunobe, Takuji Gotoda, Kenichi Ohashi, Kengo Takeuchi, Hiroshi Kawachi

{"title":"High Frequency of RhoGAP Fusion and Muscularis Mucosae Invasion in pT1a Gastric Adenocarcinoma Harboring Lymph Node Metastasis.","authors":"Chiina Hata, Hiroto Noda, Kaoru Nakano, Seiji Sakata, Kazuma Moriya, Satoko Baba, Toshiaki Hirasawa, Manabu Takamatsu, Emiko Sugawara, Noriko Yamamoto, Souya Nunobe, Takuji Gotoda, Kenichi Ohashi, Kengo Takeuchi, Hiroshi Kawachi","doi":"10.1111/pin.70032","DOIUrl":"10.1111/pin.70032","url":null,"abstract":"Gastric cancer (GC) confined to the mucosa (pT1a-GC) has a low incidence (approximately 3%) of lymph node metastasis (LNM), making it a suitable candidate for endoscopic resection. However, the current risk stratification system inadequately identifies high-risk patients. Although RhoGAP fusion has been identified as a risk factor for LNM in pT1b-GC, its role in pT1a-GC remains unclear. In the present study, medical records of 1099 surgically resected pT1a-GC cases over 12 years were reviewed, identifying 33 cases (3.0%) with LNM. A case-control study compared these cases to 99 LNM-negative cases based on clinicopathological data. Histological reviews and fluorescence In Situ hybridization assays to evaluate RhoGAP fusions, represented by CLDN18::ARHGAP26, were conducted. Univariate analysis revealed significant associations between LNM and larger tumor size (> 30 mm), mixed histological type, muscularis mucosae invasion (MMI), microtubular-mucocellular histology, and RhoGAP fusion. Multivariate analysis identified RhoGAP fusion and MMI as independent LNM predictors. Among LNM-positive cases, RhoGAP fusion was observed in 51.5% (17/33) and was associated with younger age and less frequent MMI. In conclusion, RhoGAP fusion and MMI may be significant biomarkers for LNM in pT1a-GC. Incorporating these factors could enhance risk stratification and inform clinical management strategies for pT1a-GC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"414-424"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0