Pathology International最新文献_第2页

What is the role of membrane-located epithelial cell transforming sequence 2 at the interphase of lung adenocarcinoma cells? 膜定位上皮细胞转化序列 2 在肺腺癌细胞间期的作用是什么？

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2023-12-20 DOI: 10.1111/pin.13397

Yoshihiko Murata, Ai Yoshida, Yuko Minami, Zeinab Kosibaty, Daisuke Matsubara, Masayuki Noguchi

引用次数: 0

GATA3 expression in tumor-infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo-ovarian carcinomas. 肿瘤浸润单核炎症细胞中 GATA3 的表达与输卵管卵巢癌的不良预后因素有关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1111/pin.13488

Fatemeh Nili, Elham Mirzaian, Tahereh Doustmohammadi, Somayeh Moradpanah, Fereshteh Ameli, Soheila Sarmadi, Niusha Momeni

{"title":"GATA3 expression in tumor-infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo-ovarian carcinomas.","authors":"Fatemeh Nili, Elham Mirzaian, Tahereh Doustmohammadi, Somayeh Moradpanah, Fereshteh Ameli, Soheila Sarmadi, Niusha Momeni","doi":"10.1111/pin.13488","DOIUrl":"10.1111/pin.13488","url":null,"abstract":"The study investigated the expression of GATA3, a transcription factor involved in immune regulation, in tubo-ovarian carcinomas and its association with clinicopathological factors and prognosis. Immunohistochemical analysis was performed on 91 tubo-ovarian carcinoma samples to determine the presence of GATA3-positive inflammatory cells in the tumor microenvironment. A threshold of 10% or higher was considered a positive expression. The results showed that 46.7% of tubo-ovarian carcinomas exhibited positive expression of GATA3 in inflammatory cells. There was no significant difference in GATA3 expression between patients who received pre-surgical chemotherapy and those who underwent primary surgery. However, high-grade serous carcinomas had a significantly higher proportion of GATA3-positive inflammatory cells compared to other subtypes. Advanced-stage tumors (stage III) had a higher percentage of GATA3-positive inflammatory cells compared to stage II and I tumors. Patients with positive GATA3 expression had a significantly lower disease-free survival rate. However, there was no significant association between GATA3 expression and chemotherapy response score. These findings suggest that increased expression of GATA3 in mononuclear inflammatory cells is associated with higher grade, advanced stage, and increased risk of recurrence in tubo-ovarian carcinoma. This implies that heightened GATA3 expression negatively impacts anti-tumor immunity, tumor growth progression, and invasiveness in tubo-ovarian carcinomas.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"682-690"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues.

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI: 10.1111/pin.13497

Sanae Yamazaki, Jun Miyauchi, Hideaki Sato, Yuko Takahashi, Takayuki Amikura

{"title":"Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues.","authors":"Sanae Yamazaki, Jun Miyauchi, Hideaki Sato, Yuko Takahashi, Takayuki Amikura","doi":"10.1111/pin.13497","DOIUrl":"10.1111/pin.13497","url":null,"abstract":"Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) exhibits hematological features that are indistinguishable from those of acute megakaryoblastic leukemia. However, TAM typically resolves spontaneously within several months postnatally. Some patients with TAM, however, develop severe clinical manifestations, which can lead to an unfavorable prognosis. TAM originates in utero through the acquisition of somatic GATA1 mutations, resulting in the loss of the full-length GATA1 protein and excessive production of the N-terminal truncated short isoform of the GATA1 protein (GATA1s). Herein, we report the pathological findings from an autopsy of a female stillbirth with TAM and DS, including an examination of her placental tissues. Immunohistochemical analysis revealed the expression of GATA1s, but not full-length GATA1, in CD42b-positive atypical immature megakaryocytes and blasts in the placental blood vessels. This confirms the diagnosis of TAM and suggests the utility of placental tissue for histological diagnosis. Additional unique findings from the autopsy specimens are discussed.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"708-713"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report. 前纵隔成熟囊性畸胎瘤引发的分泌性腺癌：病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-14 DOI: 10.1111/pin.13495

Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki

{"title":"Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report.","authors":"Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki","doi":"10.1111/pin.13495","DOIUrl":"https://doi.org/10.1111/pin.13495","url":null,"abstract":"Primary mediastinal apocrine adenocarcinoma is extremely rare, with only one case reported to date. Here, we report a surgical case of primary mediastinal apocrine adenocarcinoma. An anterior mediastinal cystic tumor with calcification was identified on chest computed tomography scan in a 51-year-old female patient undergoing maintenance hemodialysis. The tumor was 19 mm in size, did not invade the adjacent organs or show distant metastases, and was surgically removed. Microscopic examination revealed that the tumor cells exhibited cribriform or solid proliferation patterns with thick fibrous capsules. The tumor cells had an abundant eosinophilic cytoplasm, and decapitation secretion was noted. Immunohistochemistry revealed positivity for GCDFP-15 and androgen receptors, with Ki-67 positivity at 10%. The cyst wall exhibited extensive fibrosis and keratinized material, with bone and bronchial glands identified at the cyst periphery; the tumor cells were contiguous with those structures. The patient was diagnosed with apocrine adenocarcinoma arising from a mature cystic teratoma. The patient has maintained a recurrence-free status without adjuvant therapy for 6 years after surgery. This case presents a small primary mediastinal apocrine adenocarcinoma that achieved remarkable long-term survival.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of A Presentation by the winners of The Japanese Society of Pathology, Pathology Research Award in 2024 (in program order). 2024 年日本病理学会病理学研究奖获奖者演讲摘要（按节目顺序排列）。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 DOI: 10.1111/pin.13481

引用次数: 0

Glioneuronal and neuronal tumors: A perspective. 神经胶质细胞瘤和神经元肿瘤：透视。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1111/pin.13478

Takashi Komori

引用次数: 0

Regarding to low-grade carcinoma with acinic cell carcinoma-like features of the parotid gland with CRTC3::IQGAP1 fusion. 腮腺低分化癌伴有尖细胞癌样特征，CRTC3::IQGAP1融合。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-10-16 DOI: 10.1111/pin.13485

Ebtissam Alerraqi

引用次数: 0

Rare finding of mucorales sporangia and chlamydospores in tissue. 在组织中发现罕见的粘孢子菌孢子囊和衣孢子。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1111/pin.13476

Misa Kojima, Masatomo Kimura, Kazuhiko Kuwahara, Hisatomo Tamaki, Ryuji Yasumatsu, Sota Sadamoto, Takayuki Shinohara, Kazuki Amemiya, Yoshitsugu Miyazaki, Akihiko Ito

引用次数: 0

Colitis with subepithelial hyaline fibrosis associated with nintedanib therapy for fibrosing interstitial lung disease: A drug-related collagenous colitis? 与宁替尼治疗纤维化间质性肺病相关的上皮下透明纤维化结肠炎：与药物相关的胶原性结肠炎？

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI: 10.1111/pin.13484

Mutsuki Makino, Kenji Kawaguchi

引用次数: 0

Detection of Legionella species other than Legionella pneumophila in formalin-fixed paraffin-embedded tissue: An autopsy case study. 在福尔马林固定的石蜡包埋组织中检测嗜肺军团菌以外的军团菌：尸检病例研究。

IF 4.6 4区医学

Pathology International Pub Date : 2024-11-01 Epub Date: 2024-09-16 DOI: 10.1111/pin.13480

Miho Riku, Ritsuko Nakamura, Tsuguaki Terashima, Daisuke Sakanashi, Sosuke Nakata, Makoto Kawamura, Koji Ohnishi, Hideaki Ito, Eizo Watanabe, Hiroshige Mikamo, Kenji Kasai

{"title":"Detection of Legionella species other than Legionella pneumophila in formalin-fixed paraffin-embedded tissue: An autopsy case study.","authors":"Miho Riku, Ritsuko Nakamura, Tsuguaki Terashima, Daisuke Sakanashi, Sosuke Nakata, Makoto Kawamura, Koji Ohnishi, Hideaki Ito, Eizo Watanabe, Hiroshige Mikamo, Kenji Kasai","doi":"10.1111/pin.13480","DOIUrl":"10.1111/pin.13480","url":null,"abstract":"Diagnosing the cause of death can be challenging, particularly for patients with no prior history of visits to the treating hospital. We encountered a case involving a 76-year-old male who was discovered in a state of cardiopulmonary arrest at his home and subsequently declared deceased in our hospital due to severe pneumonia. He had exhibited symptoms of fever over 37°C and severe coughing for several days. Despite consulting a primary care physician one day prior, his symptoms worsened. Autopsy findings revealed an increase in lung weight and diffuse changes in parenchyma. Histological analysis showed numerous inflammatory cells and exudate within the alveoli. Gram and Periodic acid-Schiff staining were negative, but slight staining was observed in the cytoplasm of macrophages by Warthin-starry and Gimenez stains. Tests using a pan bacterial/viral detection kit and qualitative polymerase chain reaction (PCR) for Legionella pneumophila were negative. However, using deoxyribonucleic acid extracted from formalin-fixed paraffin-embedded lung tissue, PCR amplification of the ssrA gene of congeneric Legionella species yielded positive results. The results suggest that the cause of death was likely due to bacterial pneumonia caused by Legionella species.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"655-659"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0