Pathology International最新文献_第2页

Reduced Gene Module for Spatial Transcriptomics Recapitulates Single-Cell Molecular Classifications of Glioblastoma. 空间转录组学的减少基因模块概括了胶质母细胞瘤的单细胞分子分类。

IF 1.9 4区医学

Pathology International Pub Date : 2026-10-01 DOI: 10.1111/pin.70184

Koki Ise, Zen-Ichi Tanei, Takeru Kuwabara, Jintao He, Yoshitaka Oda, Lei Wang, Hirokazu Sugino, Ken-Ichi Sato, Masumi Tsuda, Shinya Tanaka

{"title":"Reduced Gene Module for Spatial Transcriptomics Recapitulates Single-Cell Molecular Classifications of Glioblastoma.","authors":"Koki Ise, Zen-Ichi Tanei, Takeru Kuwabara, Jintao He, Yoshitaka Oda, Lei Wang, Hirokazu Sugino, Ken-Ichi Sato, Masumi Tsuda, Shinya Tanaka","doi":"10.1111/pin.70184","DOIUrl":"https://doi.org/10.1111/pin.70184","url":null,"abstract":"Glioblastoma, IDH-wildtype, is the most common and malignant adult-type diffuse glioma. It is characterized by extensive heterogeneity and poor prognosis. Recent single-cell RNA-sequencing studies have revealed distinct transcriptional programs that define cellular states such as astrocyte-like, mesenchymal-like, neural-progenitor-cell-like, and oligodendrocyte-progenitor-cell-like. However, their spatial context remains unclear because of the limitations of single-cell and spot-based spatial transcriptomics. In the present study, we applied a single-cell molecular classification of glioblastoma to a spatial transcriptomic analysis using the Xenium in situ platform. A custom gene panel comprising 366 genes, including 100 additional genes beyond the predesigned central nervous system panel, was designed to enable high-resolution, cell-level analysis. We constructed reduced modules derived from the Neftel et al. classification and validated their reproducibility across public single-cell datasets, achieving approximately 80% concordance with the original modules. In three cases of glioblastoma, IDH-wildtype, spatial transcriptomic profiling revealed regional variations in transcriptional states; cellular tumor regions, regions of pseudopalisading necrosis were significantly enriched in reduced neural-progenitor-like-cells subtype 1, and reduced mesenchymal-like-cells subtype 2, respectively. Our data indicate that the novel reduced module provides a framework for investigating single-cell molecular states within a tissue context in glioblastoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 10","pages":"e70184"},"PeriodicalIF":1.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CY0-to-CY1 Conversion in Gastric Cancer Peritoneal Lavage Cytology: Clinical Significance and Improved Cell Retention by Et + PA Fixation. 胃癌腹膜灌洗细胞学中cy0到cy1转化：Et + PA固定改善细胞保留的临床意义。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70173

Akihiko Fukagawa, Nao Yoshizawa, Shun Iwai, Kosei Nakamura, Kota Itamoto, Ryo Wakabayashi, Shinji Hamakawa, Hirokazu Yamaguchi, Taichiro Yoshimoto

{"title":"CY0-to-CY1 Conversion in Gastric Cancer Peritoneal Lavage Cytology: Clinical Significance and Improved Cell Retention by Et + PA Fixation.","authors":"Akihiko Fukagawa, Nao Yoshizawa, Shun Iwai, Kosei Nakamura, Kota Itamoto, Ryo Wakabayashi, Shinji Hamakawa, Hirokazu Yamaguchi, Taichiro Yoshimoto","doi":"10.1111/pin.70173","DOIUrl":"10.1111/pin.70173","url":null,"abstract":"Peritoneal lavage cytology (PLC) is important for staging gastric cancer, but intraoperative assessment may miss malignant cells because only a limited portion of the specimen can be examined. We retrospectively analyzed 287 patients who underwent gastrectomy with intraoperative PLC between 2014 and 2022. Cytologic status was classified as CY-, CY0-to-CY1 conversion, or CY+ based on intraoperative and permanent cytologic findings. Of 287 patients, 251 were CY-, 10 showed CY0-to-CY1 conversion, and 26 were CY+ on intraoperative assessment, resulting in 36 final CY1 cases. Patients with CY0-to-CY1 conversion had significantly worse overall survival than CY- patients and outcomes comparable to those of CY+ patients. Serosal invasion/pT4 disease was strongly associated with final CY1 status and was frequent among conversion cases. In a separate technical evaluation, brief ethanol fixation followed by polyethylene glycol and acetone-methanol fixation (Et + PA fixation) significantly improved total cell retention and preservation of tumor-cell clusters compared with conventional ethanol fixation in 11 paired cases. CY0-to-CY1 conversion represents clinically meaningful cytology-positive disease. Et + PA fixation improves cellular retention during cytologic preparation and may improve the quality of intraoperative PLC preparations.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70173"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porto-Sinusoidal Vascular Disorder-Spectrum Portal Venopathy as a Structural Substrate for Portal Hypertension in Anti-Centromere Antibody-Positive Primary Biliary Cholangitis. 门窦血管病变-门静脉病变谱作为抗着丝粒抗体阳性原发性胆道胆管炎门静脉高压的结构底物。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70179

Yuya Ando, Suguru Mabuchi, Satoshi Nakayama, Arata Honda, Ryota Hokari, Kenichi Harada, Naoya Murashima

{"title":"Porto-Sinusoidal Vascular Disorder-Spectrum Portal Venopathy as a Structural Substrate for Portal Hypertension in Anti-Centromere Antibody-Positive Primary Biliary Cholangitis.","authors":"Yuya Ando, Suguru Mabuchi, Satoshi Nakayama, Arata Honda, Ryota Hokari, Kenichi Harada, Naoya Murashima","doi":"10.1111/pin.70179","DOIUrl":"10.1111/pin.70179","url":null,"abstract":"Anti-centromere antibody (ACA) positivity in primary biliary cholangitis (PBC) has been associated with a portal hypertension-dominant clinical trajectory, even without advanced fibrosis. This study investigated whether porto-sinusoidal vascular disorder (PSVD)-spectrum portal venopathy may underlie this phenotype. This retrospective case-series study included three ACA-positive PBC-spectrum patients who underwent liver biopsy. The clinical characteristics, imaging findings, liver and spleen stiffness, hepatic venography, and hepatic venous pressure gradient (HVPG) were evaluated. Liver specimens were assessed for PSVD-spectrum portal venopathy and PBC-related bile duct injury. All patients presented with PSVD-spectrum portal venopathy on liver biopsy; PBC-defining bile duct lesions were present in two patients, and the presence of ductular reaction was suggestive of a biliary disease but not diagnostic for PBC in one patient. All patients had manifestations of portal hypertension with preserved liver synthetic function and noncirrhotic liver stiffness. The portal sandwich sign was present in all patients. When available, spleen stiffness was markedly elevated, indicating spleen-liver stiffness dissociation. HVPG was heterogeneous, with normal values in two patients and marked elevation in one patient. In summary, PSVD-spectrum portal venopathy may contribute to disproportionate portal hypertension in ACA-positive PBC-spectrum patients but constitutes a diagnostic gray zone because PBC is defined as exclusionary in PSVD definitions.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70179"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis. 数字PCR检测间皮瘤患者胸膜液中BAP1和MTAP的缺失：在诊断中的观点

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70172

Giulia Rosini, Greta Alì, Rossella Bruno, Monica Cipollini, Rudy Foddis, Alessandra Celi, Roberto Silvestri, Filomena Rea, Vittorio Aprile, Marco Lucchi, Federica Gemignani, Stefano Landi

{"title":"Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis.","authors":"Giulia Rosini, Greta Alì, Rossella Bruno, Monica Cipollini, Rudy Foddis, Alessandra Celi, Roberto Silvestri, Filomena Rea, Vittorio Aprile, Marco Lucchi, Federica Gemignani, Stefano Landi","doi":"10.1111/pin.70172","DOIUrl":"10.1111/pin.70172","url":null,"abstract":"Pleural mesothelioma (PM) often presents loss of BAP1 and MTAP genes. Digital PCR (dPCR) can accurately measure gene copy numbers (CNs). We hypothesized that cell-free DNA (cfDNA) extracted from the supernatant of pleural fluids (SPFs) could allow an efficient detection of these genetic events. BAP1/MTAP CN was measured with dPCR in SPFs and in solid tumor biopsies (STBs) of 37 PM patients. Results were compared with immunohistochemistry (IHC) carried out in STBs. IHC alone detected BAP1/MTAP-losses in 32/37 (86.5%). However, the sensitivity improved to 34/37 (91.9%) when low CN of BAP1/MTAP was included. Among 20 patients presenting SPFs, dPCR alone detected a low CN in 18 samples (sensitivity = 90%). Finally, this two-gene signature was applied on SPFs in a prospective series of six consecutive patients presenting an undefined diagnosis (negative for PM) and two showed reduced CN. After 7 months of follow-up, these subjects were further re-evaluated for the persistence/worsening of the symptoms and were diagnosed for PM. We highlighted dPCR's potential for detecting subtle BAP1/MTAP losses in SPFs of PM patients. This appears as a complementary approach for a more accurate diagnosis in specific contexts, when high-risk patients receive negative results after IHC analysis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70172"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Fulminant Systemic Granulocytic Vasculitis Involving Arteries and Veins in Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome: An Autopsy Case Report. 急性暴发性全身粒细胞性血管炎累及空泡内动脉和静脉，E1酶，x -连锁，自身炎症，躯体（VEXAS）综合征：一个尸检病例报告。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70180

Kayo Ueda, Masakazu Fujimoto, Yumi Shiroishi, Masafumi Ito, Masahiko Osawa, Mayumi Inaba

{"title":"Acute Fulminant Systemic Granulocytic Vasculitis Involving Arteries and Veins in Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome: An Autopsy Case Report.","authors":"Kayo Ueda, Masakazu Fujimoto, Yumi Shiroishi, Masafumi Ito, Masahiko Osawa, Mayumi Inaba","doi":"10.1111/pin.70180","DOIUrl":"10.1111/pin.70180","url":null,"abstract":"Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome is a disease concept characterized by UBA1 mutation that was first proposed in 2020. We report an autopsy case of VEXAS syndrome that was retrospectively diagnosed 11 years later through genetic analysis of formalin-fixed, paraffin-embedded (FFPE) bone marrow tissue. The patient was a 65-year-old male with hepatitis C who presented with general fatigue followed by fever 2 weeks later. Shortly before death, phlebitis of the extremities and marked leukocytosis became evident. The patient died within 3 weeks of symptom onset. Autopsy revealed granulocytic vasculitis involving small- to medium-sized arteries and phlebitis in various organs, including the lungs, kidneys, liver, and lymph nodes. Concomitant myelodysplastic syndrome (MDS) was confirmed, leading to a diagnosis of MDS-associated vasculitis. Sanger sequencing of FFPE specimens 11 years later revealed a UBA1 mutation (p. Met41Val), confirming VEXAS syndrome. Although VEXAS syndrome is typically characterized by chronic, treatment-refractory inflammation and poor prognosis, autopsy reports are rare. Herein, we report an autopsy case of VEXAS syndrome associated with MDS and systemic vasculitis that presented with a fulminant clinical course.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70180"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZEB1 Promotes the Aggressive Characteristics of Pulmonary Sarcomatoid Carcinoma. ZEB1促进肺肉瘤样癌侵袭性特征。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70177

Mototsugu Ono, Shinya Endo, Masataka Tochimoto, Ako Yokoi, Yasuko Oguri, Miki Hashimura, Hiroiku Hara, Yukitoshi Satoh, Makoto Saegusa

{"title":"ZEB1 Promotes the Aggressive Characteristics of Pulmonary Sarcomatoid Carcinoma.","authors":"Mototsugu Ono, Shinya Endo, Masataka Tochimoto, Ako Yokoi, Yasuko Oguri, Miki Hashimura, Hiroiku Hara, Yukitoshi Satoh, Makoto Saegusa","doi":"10.1111/pin.70177","DOIUrl":"10.1111/pin.70177","url":null,"abstract":"To determine the role of Zinc finger E-box binding homeobox factor 1 (ZEB1) in pulmonary sarcomatoid carcinoma (PSC), we determined whether its expression in 40 PSC and 100 papillary lung carcinoma (Pap-LC) samples correlates. PSC patients with high ZEB1 had a significantly poorer prognosis when compared with Pap-LC; this was also the case for epithelial-to-mesenchymal transition (EMT) factor Slug, but not Snail or Twist1. A combined ZEB1-high and Slug-high scores appeared to be associated with the worst prognosis in PSC, suggesting that this metric may have great utility in predicting disease progression. ZEB1 was transcriptionally upregulated by the TGF-β1/Smad2 axis and ZEB1/Slug feedback loop, leading to repression of E-cadherin and induction of EMT/cancer stem cell (CSC) properties. Reduced ZEB1 expression due to ubiquitin-proteasomal degradation was associated with giant/senescent cell phenotypes. Consistent with this, ZEB1 expression was lowest in PSC samples with a high proportion of giant/senescent cell types, where prognosis was favorable. Increased expression of p21waf1, p16INK4A, and ubiquitin was concomitant with reduced ZEB1. Together, our findings reveal novel mechanistic insight into the establishment and maintenance of PSC phenotypes through ZEB1-dependent induction of EMT/CSC properties and suppression of senescence.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70177"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Bronchial Hybrid Low-Grade Fibromyxoid Sarcoma/Sclerosing Epithelioid Fibrosarcoma With EWSR1::CREB3L1 Fusion: Diagnostic Insights From a Challenging Case in the Respiratory Tract. 原发性支气管混合型低级别纤维黏液样肉瘤/硬化上皮样纤维肉瘤合并EWSR1::CREB3L1融合：来自呼吸道一个具有挑战性的病例的诊断见解

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70185

Hiroko Ikeda, Seiichi Kakegawa, Daisuke Saito, Keita Kinoshita, Ayumi Ito, Keishi Mizuguchi, Seiji Yano, Tomohiro Kobayashi, Satoshi Kobayashi, Akihiro Nishiyama, Shinji Takeuchi, Isao Matsumoto

{"title":"Primary Bronchial Hybrid Low-Grade Fibromyxoid Sarcoma/Sclerosing Epithelioid Fibrosarcoma With EWSR1::CREB3L1 Fusion: Diagnostic Insights From a Challenging Case in the Respiratory Tract.","authors":"Hiroko Ikeda, Seiichi Kakegawa, Daisuke Saito, Keita Kinoshita, Ayumi Ito, Keishi Mizuguchi, Seiji Yano, Tomohiro Kobayashi, Satoshi Kobayashi, Akihiro Nishiyama, Shinji Takeuchi, Isao Matsumoto","doi":"10.1111/pin.70185","DOIUrl":"10.1111/pin.70185","url":null,"abstract":"Hybrid low-grade fibromyxoid sarcoma/sclerosing epithelioid fibrosarcoma (LGFMS/SEF) is an ultra-rare fibroblastic sarcoma that typically arises in the soft tissues. Primary involvement of the respiratory tract is extremely uncommon, and, to our knowledge, no cases arising in the bronchial wall have previously been reported. We describe a hybrid LGFMS/SEF arising in the right bronchus of a Japanese woman in her 40 s. The 2-cm tumor was incidentally detected, and imaging studies demonstrated no other lesions. Histologically, the tumor consisted predominantly of bland spindle cells within fibromyxoid stroma with collagen rosettes, admixed with epithelioid fibroblasts arranged in cords. Immunohistochemically, the tumor showed diffuse positivity for MUC4. Comprehensive genomic profiling performed for diagnostic purposes identified an EWSR1::CREB3L1 fusion gene, supporting the diagnosis of hybrid LGFMS/SEF. Retrospective review of the transbronchial biopsy specimen revealed subtle spindle cells showing MUC4 expression by immunohistochemistry and EWSR1 rearrangement by fluorescence in situ hybridization, which had initially been interpreted as inflammatory change. This case highlights important diagnostic pitfalls of hybrid LGFMS/SEF and provides the clinicopathological insights into EWSR1::CREB3L1-associated fibroblastic sarcoma arising in the bronchial wall.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70185"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13614296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Diagnosis of Nodal T Follicular Helper Cell Lymphoma, Angioimmunoblastic Type. 结型T滤泡辅助细胞淋巴瘤的病理诊断。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70186

Naoya Nakamura, Yara Yukie Kikuti, Joaquim Carreras, Ryota Matsuoka, Daisuke Matsubara, Sakurako Suma, Mamiko Sakata-Yanagimoto, Yohei Masugi

引用次数: 0

A Spinal Cord Sarcoma With EWSR1::WT1 Fusion Exhibited Ewing Sarcoma-Like Pattern Rather Than Desmoplastic Small Round Cell Tumor. EWSR1::WT1融合的脊髓肉瘤表现为尤文氏肉瘤样，而不是结缔组织增生小圆细胞瘤。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70181

Chuqian Zeng, Yishan Wang

引用次数: 0

Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation. 脂肪肿瘤学的现状和未来展望：脂肪细胞在局部和全身肿瘤调节中的作用。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70170

Shinya Sato

{"title":"Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation.","authors":"Shinya Sato","doi":"10.1111/pin.70170","DOIUrl":"10.1111/pin.70170","url":null,"abstract":"Adipose tissue has traditionally been regarded as an energy-storage organ; however, accumulating evidence indicates that adipocytes actively regulate cancer biology through local and systemic mechanisms. These findings have contributed to the emergence of adipo-oncology, an interdisciplinary field focused on interactions between adipose tissue and cancer. This review summarizes current evidence on the local and systemic roles of adipocytes in tumor progression and discusses how tissue heterogeneity and plasticity may influence these processes. Locally, adipocytes adjacent to tumors may be reprogrammed into cancer-associated adipocytes that promote tumor progression through enhanced lipolysis and inflammatory signaling, paracrine adipokine and cytokine secretion, local lipid transfer, and modulation of stromal and immune cell populations within the tumor microenvironment. Systematically, adipocytes may influence metabolic remodeling, epithelial-mesenchymal transition, invasion, metastasis, therapeutic resistance, and establishment of tumor-promoting niches. Additionally, adipocyte plasticity and epigenetic reprogramming have emerged as important determinants of adipocyte function during cancer progression. Collectively, these findings support a model in which adipocytes function as central regulators of cancer biology at local and systemic levels. A deeper understanding of the molecular basis of adipo-oncology may provide new insights into tumor progression and facilitate the development of metabolic, immunological, and epigenetic therapeutic strategies targeting adipose tissue.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70170"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0