Pathology International最新文献_第2页

The Role of Artificial Intelligence in the Evaluation of Prostate Pathology. 人工智能在前列腺病理评估中的作用。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1111/pin.70015

Lars Egevad, Andrea Camilloni, Brett Delahunt, Hemamali Samaratunga, Martin Eklund, Kimmo Kartasalo

{"title":"The Role of Artificial Intelligence in the Evaluation of Prostate Pathology.","authors":"Lars Egevad, Andrea Camilloni, Brett Delahunt, Hemamali Samaratunga, Martin Eklund, Kimmo Kartasalo","doi":"10.1111/pin.70015","DOIUrl":"10.1111/pin.70015","url":null,"abstract":"Artificial intelligence (AI) is an emerging tool in diagnostic pathology, including prostate pathology. This review summarizes the possibilities offered by AI and also discusses the challenges and risks. AI has the potential to assist in the diagnosis and grading of prostate cancer. Diagnostic safety can be enhanced by avoiding the accidental underdiagnosis of small lesions. Another possible benefit is a greater degree of standardization of grading. AI for clinical use needs to be trained on large, high-quality data sets that have been assessed by experienced pathologists. A problem with the use of AI in prostate pathology is the plethora of benign mimics of prostate cancer and morphological variants of cancer that are too unusual to allow sufficient training of AI. AI systems need to be able to account for variations in local routines for cutting, staining, and scanning of slides. We also need to be aware of the risk that users will rely too much on the output of an AI system, leading to diagnostic errors and loss of clinical competence. The reporting pathologist must ultimately be responsible for accepting or rejecting the diagnosis proposed by AI.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"213-220"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nemaline bodies are not always congenital: A case of sporadic late-onset nemaline myopathy (SLONM) with monoclonal gammopathy of undetermined significance (MGUS). 线状体并不总是先天性的：1例散发性迟发性线状肌病（SLONM）合并意义不明的单克隆伽玛病（MGUS）。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-02-03 DOI: 10.1111/pin.70000

Silvie Thomas, Deepti Narasimhaiah, Sruthi S Nair, Bejoy Thomas, Rashmi Santhoshkumar, Anita Mahadevan, Rajalakshmi Poyuran

引用次数: 0

Follicular Dendritic Cell Sarcoma of the Parapharyngeal Space Arising in Association With Castleman Disease. 与Castleman病相关的咽旁间隙滤泡树突状细胞肉瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-02 DOI: 10.1111/pin.70007

Shunsuke Koga, Wei Du, Gabriel C Caponetti, Kumarasen Cooper

引用次数: 0

A Case of Leiomyoadenomatoid Tumor of the Epididymis Mimicking Epithelioid Mesothelioma. 附睾平滑肌腺瘤样肿瘤模拟上皮样间皮瘤1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.1111/pin.70010

Aohiro Sanematsu, Kyonosuke Teruya, Kazuki Nabeshima, Kei Tanaka, Junichi Inokuchi, Akihiro Nishie, Fumi Kawakami

引用次数: 0

A Potential Case of Tubulocystic Ductal Carcinoma of the Pancreas. 胰腺小管囊性导管癌1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1111/pin.70008

Rena Uno, Yoh Zen, Tomonori Tanaka, Hirochika Toyama, Takumi Fukumoto, Keitaro Sofue, Tomoo Itoh

{"title":"A Potential Case of Tubulocystic Ductal Carcinoma of the Pancreas.","authors":"Rena Uno, Yoh Zen, Tomonori Tanaka, Hirochika Toyama, Takumi Fukumoto, Keitaro Sofue, Tomoo Itoh","doi":"10.1111/pin.70008","DOIUrl":"10.1111/pin.70008","url":null,"abstract":"We present a case of pancreatic ductal carcinoma with a microcystic appearance. A 64-year-old woman was found to have a pancreatic mass during a routine medical checkup. The tumor was well-circumscribed and multicystic; thus, she was followed up for suspected serous cystadenoma. However, the tumor gradually enlarged in the following 2.5 years; subsequently, she underwent a Whipple procedure. Grossly, the cut surface of the tumor was honeycomb-like with small cysts. Histologically, the cysts were ductal structures lined by a relatively bland, cuboidal or columnar epithelium with mildly enlarged nuclei. No intracytoplasmic mucus was observed. The presence of stromal invasion confirmed the diagnosis of ductal carcinoma. KRAS was wild type. Postoperative course was uneventful, with no recurrence to date (followup period: 5.5 years postsurgery). The present case did not meet any known subtypes of pancreatic ductal carcinoma. The tumor resembled a large duct variant, which typically shows a microcystic appearance. However, unlike the present case, the large duct type usually consists of mucus-rich neoplastic cells. A recent study on cholangiocarcinoma proposed a novel tubulocystic subtype characterized by microcystic neoplastic glands and adenofibromatous stroma, which is morphologically similar to the present case. The present case may correspond to a pancreatic counterpart of tubulocystic cholangiocarcinoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"243-246"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal Trends in Etiology of Aortic Valvular Diseases for Patients Undergoing Surgical Valve Replacement: A Report From 40 Years Pathological Experience. 主动脉瓣置换术患者主动脉瓣疾病病因的时间趋势：一份40年病理经验报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-04-17 DOI: 10.1111/pin.70009

Kisaki Amemiya, Hatsue Ishibashi-Ueda, Yoshihiko Ikeda, Manabu Matsumoto, Keiko Ohta-Ogo, Satsuki Fukushima, Tomoyuki Fujita, Kinta Hatakeyama

{"title":"Temporal Trends in Etiology of Aortic Valvular Diseases for Patients Undergoing Surgical Valve Replacement: A Report From 40 Years Pathological Experience.","authors":"Kisaki Amemiya, Hatsue Ishibashi-Ueda, Yoshihiko Ikeda, Manabu Matsumoto, Keiko Ohta-Ogo, Satsuki Fukushima, Tomoyuki Fujita, Kinta Hatakeyama","doi":"10.1111/pin.70009","DOIUrl":"10.1111/pin.70009","url":null,"abstract":"Although aortic valvular disease has various etiologies, recently, calcific aortic valve stenosis has been increasing. We analyzed the trends in the pathological characteristics of aortic valvular disease in the past four decades in Japan. The pathology department data for aortic valvular disease operated in our hospital documented 4508 patients from 1978 to 2022. Subsequently, trend analyses were performed over four periods: Period 1, 1978-1989 (618 cases); Period 2, 1990-1999 (903 cases); Period 3, 2000-2010 (1179 cases); and Period 4, 2011-2022 (1808 cases). We reviewed the pathological characterization of the resected aortic valves and categorized them based on the representative etiology of aortic valvular disease as congenital bicuspid, chronic rheumatic change, infective endocarditis, degenerative calcific change, and myxoid change. Our pathologic analysis revealed a significant decrease in the proportion of chronic rheumatic disease from 47% to 14%, an increase in the congenital bicuspid valve from 8% to 24%, and a rise of the degenerative calcific change of the aortic valve from 4% to 27% (p < 0.001), especially significant increases in aortic stenosis. Calcification of the aortic valve may result from an active process similar to atherosclerosis, leading to aortic stenosis with increasing dyslipidemia in Japanese patients in 40 years.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"228-235"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers. ki67标记指数在ER+/HER2-乳腺癌针芯活检标本中的可靠性

IF 2.5 4区医学

Pathology International Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.1111/pin.70005

Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita

{"title":"Reliability of Ki67-Labeling Index in Core Needle Biopsy Specimens of ER+/HER2- Breast Cancers.","authors":"Yumi Fukaya, Makoto Wakahara, Keiko Hosoya, Naoko Nouchi, Yoshihisa Umekita","doi":"10.1111/pin.70005","DOIUrl":"10.1111/pin.70005","url":null,"abstract":"The reliability of Ki67-labeling index (LI) in core needle biopsy (CNB) of ER+/HER2- invasive breast carcinoma (IBC) and factors affecting the discordance of Ki67-LI between CNB and surgical resection (SR) remain unsolved. We aimed to elucidate factors influencing the discordance of Ki67-LI between CNB and SR to classify ER+/HER2- IBC into luminal A-like (LumA) and luminal B-like (LumB). The cohort included 326 ER+/HER2- IBCs available with Ki67-LI data at both CNB and SR specimens. Survival analysis was performed on 122 patients. Spearman's rank correlation coefficient of Ki67-LI between them was 0.683. The log-rank test showed that patients with ER+/HER2- IBC with ≥ 20% Ki67-LI at CNB (p < 0.001) and SR specimens (p < 0.001) had significantly shorter disease-free survival. In multivariate analysis, a negative PgR (p = 0.002) and > 2 cm pathological tumor size (p < 0.001) had the most significant effect on the discordance of Ki67-LI between CNB and SR at 20% and 30% cutoffs, respectively. Histological grade III had a significant effect on the concordance between them (p = 0.01) at 20% cutoff. Ki67-LI assessment in CNB may be useful for classifying ER+/HER2- IBC into LumA and LumB with caution of some prognostic factors and cutoffs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"221-227"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prominent Trabecular/Nested Growth Pattern in Mucoepidermoid Carcinoma May be Formed Primarily by the Fourth Cell Type, Namely Cells With a Columnar Cell Lineage. 黏液表皮样癌中突出的小梁/巢状生长模式可能主要由第四种细胞类型形成，即具有柱状细胞谱系的细胞。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-23 DOI: 10.1111/pin.70016

Shinnichi Sakamoto, Fumio Ide, Miyako Hoshino, Michiko Nishimura, Kentaro Kikuchi

引用次数: 0

Autopsy Case of Severe Right Heart Failure Accompanied by Pulmonary Arterial Hypertension With Suspected Osler's Disease. 严重右心衰伴肺动脉高压疑似奥斯勒氏病尸检1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-23 DOI: 10.1111/pin.70017

Moe Matsumoto, So Osato, Chiemi Oishi, Komei Mizokami, Kazuya Hosokawa, Keimei Yoshida, Kohtaro Abe, Yoshionao Oda, Shinichi Aishima

引用次数: 0

Pigmented Carcinoid in the Rectum. 直肠色素样癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-15 DOI: 10.1111/pin.70013

Takushi Hara, Kotaro Shibagaki, Mamiko Nagase, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba, Naoki Oshima, Norihisa Ishimura, Asuka Araki, Daisuke Niino, Shunji Ishihara

引用次数: 0