Pathology International最新文献_第3页

Autopsy Case of Severe Right Heart Failure Accompanied by Pulmonary Arterial Hypertension With Suspected Osler's Disease. 严重右心衰伴肺动脉高压疑似奥斯勒氏病尸检1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-23 DOI: 10.1111/pin.70017

Moe Matsumoto, So Osato, Chiemi Oishi, Komei Mizokami, Kazuya Hosokawa, Keimei Yoshida, Kohtaro Abe, Yoshionao Oda, Shinichi Aishima

引用次数: 0

Pigmented Carcinoid in the Rectum. 直肠色素样癌。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-15 DOI: 10.1111/pin.70013

Takushi Hara, Kotaro Shibagaki, Mamiko Nagase, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba, Naoki Oshima, Norihisa Ishimura, Asuka Araki, Daisuke Niino, Shunji Ishihara

引用次数: 0

Ultrastructural and Immunohistochemical Study of a Gastric Bizarre Leiomyoma: Bizarre Nuclei and Prominent Cytoplasmic Processes Extending Into and Displacing the Stroma. 胃奇异性平滑肌瘤的超微结构和免疫组织化学研究：奇异核和突出的细胞质突起延伸并取代基质。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-14 DOI: 10.1111/pin.70014

Kaoru Furihata, Waka Iwashita, Atsushi Kurabayashi, Kojima Koji, Mutsuo Furihata

{"title":"Ultrastructural and Immunohistochemical Study of a Gastric Bizarre Leiomyoma: Bizarre Nuclei and Prominent Cytoplasmic Processes Extending Into and Displacing the Stroma.","authors":"Kaoru Furihata, Waka Iwashita, Atsushi Kurabayashi, Kojima Koji, Mutsuo Furihata","doi":"10.1111/pin.70014","DOIUrl":"https://doi.org/10.1111/pin.70014","url":null,"abstract":"This study presents the ultrastructural and immunohistochemical findings of a gastric bizarre leiomyoma arising in the vestibule of a 79-year-old male. Histologically, loosely proliferating tumor cells consist of large, multinucleated, bizarre nuclei with intranuclear inclusions and abundant cytoplasm-containing vacuoles. A murky line was apparent between the tumor cells and eosinophilic and heterogenous stroma-like areas. Immunohistochemically, tumor cells exhibited positively stained dot patterns of α-smooth muscle actin and caldesmon, which were distributed in the cytoplasm of tumor cells and stroma-like regions. Ultrastructurally, tumor cells exhibited extended and complex cytoplasmic processes comprising the fascicles of filamentous fibers. These structures were also detected in the apparent stroma-like regions observed histologically and were consistent with the α-smooth muscle actin- and caldesmon-immunopositive dot structures. The original stromal areas remained as considerably narrow gaps between tumor cells with extended cytoplasmic processes. To the best of our knowledge, this is the first report detailing the unique ultrastructural and immunohistochemical characteristics of tumor cells and the limited stromal composition of an extremely rare primary gastric bizarre leiomyoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer. NANOG/HDAC1表达在预测非肌性浸润性膀胱癌卡介苗治疗预后中的价值

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.1111/pin.70002

Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose

{"title":"Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non-Muscle Invasive Bladder Cancer.","authors":"Takahisa Yamashita, Morihiro Higashi, Mami Yamazaki, Hiroki Imada, Natsuko Takayanagi, Tomomi Shimizu, Keisuke Sawada, Wataru Yamamoto, Chiaki Murakami, Marino Nagata, Yukina Kikuchi, Shuji Momose","doi":"10.1111/pin.70002","DOIUrl":"10.1111/pin.70002","url":null,"abstract":"Urinary bladder cancer includes non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). While patients with NMIBC have a better prognosis, NMIBC often recurs, requiring long-term surveillance and repeated treatments. Intravesical Bacillus Calmette-Guérin (BCG) therapy is standard for high-grade or recurrent NMIBC; however, 30%-50% of patients failed to respond, and the mechanisms of resistance remain unclear. To identify predictive biomarkers for response to intravesical BCG therapy, we analyzed NANOG and Histone deacetylase 1 (HDAC1) expression in 90 bladder cancer specimens from NMIBC patients treated with BCG therapy using immunohistochemistry. The correlation between NANOG and HDAC1 expression and clinical outcomes, including response to BCG therapy, was assessed. High-grade NMIBC cases showed significantly higher expression of NANOG and HDAC1 compared to low-grade cases (p < 0.05). Additionally, elevated NANOG expression in combination with HDAC1, was associated with poor response to BCG therapy and decreased lymphocyte infiltration in the tumor-microenvironment. NANOG is suggested to directly increases HDAC1 expression, which could suppress lymphocyte infiltration in the tumor microenvironment by altering immune-related gene expression. These findings suggest that the NANOG/HDAC1 axis plays a key role in predicting resistance to intravesical BCG therapy in NMIBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"177-183"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of presentation by the winners of The Japanese Society of Pathology; Japan Pathology Award in 2025 (in program order). 日本病理学会获奖者演讲摘要；荣获2025年日本病理学奖（按项目先后顺序）。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 DOI: 10.1111/pin.13515

引用次数: 0

Myxoid spindle cell tumor with EWSR1-CREM fusion mimicking papillary adenoma of the lung. 黏液样梭形细胞瘤与EWSR1-CREM融合，模拟肺乳头状腺瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13517

Yurie Okayama, Shin Ishizawa, Akane Aikawa, Yuko Nakanishi, Akio Uchiyama, Tomohiko Takahashi, Yasushi Yatabe

引用次数: 0

Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report. 仿畸胎性肺癌肉瘤1例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-03-27 DOI: 10.1111/pin.70006

Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito

{"title":"Pulmonary Carcinosarcoma Imitating Teratocarcinosarcoma: A Case Report.","authors":"Naoko Shigeta, Tomoyuki Yokose, Tetsuya Isaka, Takuya Nagashima, Haruhiro Saito, Hiroyuki Ito, Aya Saito","doi":"10.1111/pin.70006","DOIUrl":"10.1111/pin.70006","url":null,"abstract":"Pulmonary carcinosarcoma is a rare tumor composed of non-small-cell carcinomas and sarcomatous elements, which is poorly differentiated in most cases. We present a case of carcinosarcoma with a well-differentiated carcinomatous component that required a differential diagnosis from tumors derived from teratomas, such as teratocarcinosarcoma. We present a case of a 68-year-old man who visited our hospital for an examination of a 22-mm lung tumor. The patient underwent left S1+2 segmentectomy, and his postoperative course was uneventful. No recurrence was observed in the 21-month postoperative follow-up period. The segmentectomy specimen revealed a yellow-white, well-circumscribed mass. The tumor consisted of well-differentiated squamous and glandular epithelia, and sarcomatous components of immature spindle cells, chondrosarcoma, and rhabdomyosarcoma. The patient was diagnosed with carcinosarcoma. This case included well-differentiated carcinomatous components, and it was necessary to differentiate it from teratocarcinosarcomas. There was no neural component, and without SMARCA4 loss, which is observed in teratocarcinosarcoma, and ruled out teratocarcinosarcoma. Carcinosarcomas are characterized by a biphasic histopathological pattern, making it difficult to accurately diagnose them on biopsy, which only captures a portion of the tumor. The possibility of carcinosarcoma should be considered even when the tumors derived from teratomas are suspected on preoperative biopsy.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"196-202"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical choroid plexus papilloma arising in a mature ovarian teratoma, a case report. 不典型脉络丛乳头状瘤产生于成熟卵巢畸胎瘤1例。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13513

Brandon Gehris, Songlin Zhang, Xiaohong Iris Wang

引用次数: 0

A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer. 一种改进的乳腺癌he染色切片肿瘤浸润淋巴细胞评价系统的建议。

IF 2.5 4区医学

Pathology International Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1111/pin.70004

Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda

{"title":"A Proposal for a Modified Evaluation System of Tumor-Infiltrating Lymphocytes Using HE-Stained Sections in Breast Cancer.","authors":"Ryo Kikuchi, Hoshiho Kubota, Yuuki Nishimura, Kazutaka Gomisawa, Kenji Kobayashi, Toshinori Otani, Tomoe Lu, Masaki Yoda, Atsushi Fushimi, Hiroko Nogi, Takashi Ohtsuka, Masayuki Shimoda","doi":"10.1111/pin.70004","DOIUrl":"10.1111/pin.70004","url":null,"abstract":"Tumor-infiltrating lymphocyte (TIL) scoring in tumor specimens has gained increasing attention in determining patients who are likely to benefit from immunotherapies. However, the histological evaluation methods of TILs in breast cancer remain limited. This study aimed to assess four components of lymphocytic reaction and overall lymphocytic score (L-score) used in colorectal cancer, investigate its association with clinicopathological factors, and examine the effect of TILs on postoperative mortality using 231 invasive breast cancers without neoadjuvant chemotherapy. Besides L-score, increasing modified L-score lacking peritumoral lymphocytic reaction was significantly associated with aggressive breast cancer phenotypes, including larger invasive size, higher tumor stage, higher Ki-67 labeling index, triple negative and HER2-enriched subtypes, and higher Nottingham histological grade. Importantly, modified L-score status but not L-score or TIL-Working Group (WG) score status was positively correlated with the disease-specific survival rate of the overall patients as well as the patients with luminal type or histological Grade III breast cancers. These results indicated that the modified L-score is a favorable method to comprehensively assess lymphocytic reaction to predict prognosis among patients with breast cancer, even compared with the currently used TIL-WG method, which may possess their potential integration into clinical practice.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"184-195"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichosporon hyphae should be carefully differentiated from Aspergillus hyphae in tissue: A case report. 应仔细区分组织中的毛丝虫丝和曲霉丝：1例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-03-01 Epub Date: 2025-01-27 DOI: 10.1111/pin.13514

Masatomo Kimura, Fumiaki Ono, Takaaki Chikugo, Takashi Sugita

引用次数: 0