Pathology International最新文献_第3页

Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation. 脂肪肿瘤学的现状和未来展望：脂肪细胞在局部和全身肿瘤调节中的作用。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70170

Shinya Sato

{"title":"Current and Future Perspectives on Adipo-Oncology: Roles of Adipocytes in Local and Systemic Tumor Regulation.","authors":"Shinya Sato","doi":"10.1111/pin.70170","DOIUrl":"10.1111/pin.70170","url":null,"abstract":"Adipose tissue has traditionally been regarded as an energy-storage organ; however, accumulating evidence indicates that adipocytes actively regulate cancer biology through local and systemic mechanisms. These findings have contributed to the emergence of adipo-oncology, an interdisciplinary field focused on interactions between adipose tissue and cancer. This review summarizes current evidence on the local and systemic roles of adipocytes in tumor progression and discusses how tissue heterogeneity and plasticity may influence these processes. Locally, adipocytes adjacent to tumors may be reprogrammed into cancer-associated adipocytes that promote tumor progression through enhanced lipolysis and inflammatory signaling, paracrine adipokine and cytokine secretion, local lipid transfer, and modulation of stromal and immune cell populations within the tumor microenvironment. Systematically, adipocytes may influence metabolic remodeling, epithelial-mesenchymal transition, invasion, metastasis, therapeutic resistance, and establishment of tumor-promoting niches. Additionally, adipocyte plasticity and epigenetic reprogramming have emerged as important determinants of adipocyte function during cancer progression. Collectively, these findings support a model in which adipocytes function as central regulators of cancer biology at local and systemic levels. A deeper understanding of the molecular basis of adipo-oncology may provide new insights into tumor progression and facilitate the development of metabolic, immunological, and epigenetic therapeutic strategies targeting adipose tissue.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70170"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urothelial Carcinoma With Loss of SMARCA4 Expression With the Site of Origin Identified by Detailed Autopsy Investigation. 尿路上皮癌伴SMARCA4表达缺失，起源部位通过详细的尸检调查确定。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70157

Takeru Kishinami, Yoshitaka Oda, Zen-Ichi Tanei, Takahiro Osawa, Riku Manabe, Ryoko Watanabe, Yuki Hirosato, Yuki Uchida, Akira Nishibe, Kazuhiro Ujihashi, Hiroki Chiba, Takeru Kuwabara, Koki Ise, Ken Enda, Yusuke Shirai, Hirokazu Sugino, Lei Wang, Masumi Tsuda, Takashige Abe, Shinya Tanaka

引用次数: 0

Acral Fibrochondromyxoid Tumor: Diagnostic Challenges and Multimodal Characterization in a Hand Mass Case. 肢端纤维软骨粘液样瘤：一个手部肿块病例的诊断挑战和多模态特征。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70174

Liying Zhang, Pinglian Yang, Yunzhu Zeng, Anjia Han, Xiaolong Wei

{"title":"Acral Fibrochondromyxoid Tumor: Diagnostic Challenges and Multimodal Characterization in a Hand Mass Case.","authors":"Liying Zhang, Pinglian Yang, Yunzhu Zeng, Anjia Han, Xiaolong Wei","doi":"10.1111/pin.70174","DOIUrl":"10.1111/pin.70174","url":null,"abstract":"Acral fibrochondromyxoid tumor (AFCMT) is a rare and recently characterized matrix-rich soft tissue occurring on acral sites. Here, we conducted a multi-dimensional analysis of AFCMT that occurred in the hands from clinical, image, pathological, and molecular perspectives, and discussed its clinicopathological features and diagnostic strategies. In general, the hand appears as a clearly demarcated lump. In the image, scattered calcifications can be observed, along with the proliferation of mucinous cartilage matrix. Microscopically, pale eosinophilic chondrocyte-like cells are suspended within the abundant chondromyxoid matrix. The tumor cells showed immunoreactivity for CD34, ERG, SOX9 and Vimentin, supporting mesenchymal lineage differentiation. Interestingly, transcriptome-wide sequencing identifies the characteristic THBS1::ADGRF5 gene fusion, further clarifying its molecular signature. AFCMT is frequently underrecognized due to its rarity, nonspecific clinicoradiological features, and histological overlap with other fibromyxoid or cartilaginous lesions. This case highlights the importance of multimodal diagnostic strategies, improving multidisciplinary awareness and management capabilities of soft tissue tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70174"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline TP53 Polymorphism and Its Interaction With Somatic TP53 Mutations Shapes Response to Immune Checkpoint Inhibitors in Nonsmall Cell Lung Cancer: The Role of TP53 p.R72P as a Germline Biomarker. 生殖系TP53多态性及其与体细胞TP53突变的相互作用决定了非小细胞肺癌患者对免疫检查点抑制剂的反应：TP53 p.R72P作为生殖系生物标志物的作用

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70183

Selin Kurt, Kritika Krishnamurthy

{"title":"Germline TP53 Polymorphism and Its Interaction With Somatic TP53 Mutations Shapes Response to Immune Checkpoint Inhibitors in Nonsmall Cell Lung Cancer: The Role of TP53 p.R72P as a Germline Biomarker.","authors":"Selin Kurt, Kritika Krishnamurthy","doi":"10.1111/pin.70183","DOIUrl":"10.1111/pin.70183","url":null,"abstract":"Germline TP53 p.R72P polymorphism has been associated with lung cancer susceptibility, somatic TP53 mutation acquisition, and differential apoptotic signaling. Its influence on pathologic response to neoadjuvant immune checkpoint inhibition (ICI) has not been previously evaluated. This study investigates the impact of germline TP53 p.R72P genotype on response to neoadjuvant ICI therapy in nonsmall cell lung cancer (NSCLC). NSCLC patients treated with neoadjuvant anti-PD-1 therapy followed by resection were stratified by germline p.R72P status and the presence of concomitant somatic TP53 mutations. Histopathologic review assessed immunotherapy-associated histopathologic features of tumor regression, and the findings were correlated with PD-L1 tumor proportion scores (TPS) and next-generation sequencing data. The subgroup harboring both germline p.R72P and somatic TP53 mutations achieved a complete pathologic response (cPR) rate of 75% (3 of 4 cases), numerically higher than that observed in p.R72P-positive/TP53-wild-type tumors (25%, 2 of 8 cases), p.R72P-negative/TP53-mutant tumors (50%, 4 of 8 cases), and p.R72P-negative/TP53-wild-type controls (0%, 0 of 6 cases) (p < 0.05). In this single-center, exploratory cohort, germline TP53 p.R72P status was associated with differences in pathologic response to neoadjuvant therapy. Tumors with combined germline p.R72P polymorphism and somatic TP53 mutation might represent a genomic subgroup with a higher cPR rate.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70183"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Transformation in Pathology: A Digital-First Model for Integrated Diagnostic Systems. 病理学的数字化转型：综合诊断系统的数字化优先模型。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70171

Hiroyuki Kusano, Takayuki Shiomi

{"title":"Digital Transformation in Pathology: A Digital-First Model for Integrated Diagnostic Systems.","authors":"Hiroyuki Kusano, Takayuki Shiomi","doi":"10.1111/pin.70171","DOIUrl":"10.1111/pin.70171","url":null,"abstract":"Digital pathology has rapidly expanded over the past decade, driven by advances in whole-slide imaging and increasing demand for remote and data-integrated diagnostic workflows. However, many implementations remain limited to partial digitization, without fundamentally transforming laboratory and diagnostic processes. In this review, we examine digital transformation in pathology as a systems-level redesign encompassing workflow optimization, digital infrastructure, and networked diagnostic services. Using the implementation at International University of Health and Welfare (IUHW) Narita Hospital as an illustrative example, we describe how a digital-first approach can be integrated into routine clinical practice. Key elements include continuous laboratory workflows aligned with slide digitization, comprehensive digital infrastructure enabling seamless access to diagnostic data, and networked systems that support multi-institutional collaboration and subspecialty consultation. We further discuss how digital pathology extends beyond clinical diagnosis to support education and research, transforming traditional slide archives into accessible data resources, and outline practical considerations for implementation, including workflow redesign, user adoption, and institutional coordination. Finally, by comparing the IUHW Narita experience with other large-scale implementations, we discuss generalizable principles for digital transformation in pathology, including workflow-driven design, data integration, interoperability, and network-based diagnostic models.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70171"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biglycan Secreted by Tumor Stromal Cells Is a Predictive Marker for the Early Recurrence of Pancreatic Cancer. 肿瘤间质细胞分泌的Biglycan是胰腺癌早期复发的预测指标。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70175

Hironori Tanaka, Nako Maishi, Aya Matsuda, Hirofumi Morimoto, Masakazu Fujii, Takuya Tsumita, Tomoko Mitsuhashi, Yoshihiro Matsuno, Yasuhiro Hida, Toru Nakamura, Satoshi Hirano, Kyoko Hida

{"title":"Biglycan Secreted by Tumor Stromal Cells Is a Predictive Marker for the Early Recurrence of Pancreatic Cancer.","authors":"Hironori Tanaka, Nako Maishi, Aya Matsuda, Hirofumi Morimoto, Masakazu Fujii, Takuya Tsumita, Tomoko Mitsuhashi, Yoshihiro Matsuno, Yasuhiro Hida, Toru Nakamura, Satoshi Hirano, Kyoko Hida","doi":"10.1111/pin.70175","DOIUrl":"10.1111/pin.70175","url":null,"abstract":"Pancreatic cancer carries a poor prognosis due to its dense fibrotic stroma and high rate of metastatic recurrence. Reliable biomarkers for early detection and recurrence prediction remain lacking. We previously reported that biglycan (BGN), derived from tumor endothelial cells, a key component of the cancer stroma, promotes tumor progression by enhancing angiogenesis, cell migration, and metastasis. This study aimed to evaluate the association between BGN expression in pancreatic cancer and early recurrence. We performed immunohistochemistry for BGN and collagen fibers on resected pancreatic cancer tissues from 98 patients who underwent curative resection. Quantitative analyses included BGN-positive area, tumor fibrosis area, and cross-linked collagen area. In addition, a BGN-knockout (BGN-KO) mouse pancreatic tumor model was generated to investigate the functional role of BGN in the tumor microenvironment. It revealed that both the BGN-positive area and cross-linked collagen area were significantly increased in the early recurrence group compared with the 5-year survival group. In the mouse model, BGN-KO tumors exhibited significantly reduced fibrosis and cross-linked collagen deposition, features indicative of decreased tumor stiffness, compared with tumors in wild-type (WT) mice. Thus, BGN contributes to tumor stromal stiffness and may serve as a predictive biomarker for early recurrence in pancreatic cancer.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70175"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13575590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HuR-ΔNp63 Regulation and E-Cadherin Expression in Tumor Budding and Bone Remodeling of Ameloblastoma. HuR-ΔNp63在成釉细胞瘤出芽和骨重塑中的调控及E-Cadherin的表达。

IF 1.9 4区医学

Pathology International Pub Date : 2026-09-01 DOI: 10.1111/pin.70178

Saki Shinohara, Tetsuya Kitamura, Aya Yanagawa Matsuda, Fumihiro Higashino, Nako Maishi, Yoichi Ohiro, Kanchu Tei, Kyoko Hida

{"title":"HuR-ΔNp63 Regulation and E-Cadherin Expression in Tumor Budding and Bone Remodeling of Ameloblastoma.","authors":"Saki Shinohara, Tetsuya Kitamura, Aya Yanagawa Matsuda, Fumihiro Higashino, Nako Maishi, Yoichi Ohiro, Kanchu Tei, Kyoko Hida","doi":"10.1111/pin.70178","DOIUrl":"10.1111/pin.70178","url":null,"abstract":"Ameloblastoma is a benign odontogenic tumor characterized by locally infiltrative growth and a high recurrence rate despite minimal cytological atypia. Histologically, tumor budding-small epithelial projections arising from tumor nests-is frequently observed and has been suggested to be associated with recurrence; however, its molecular basis and pathological significance remain unclear. This study aimed to clarify the molecular characteristics of tumor budding, its relationship with surrounding bone remodeling, and its possible contribution to tumor recurrence. Immunohistochemical analyses revealed that HuR and ΔNp63 were co-expressed in budding areas of ameloblastoma. In vitro experiments using the AM-1 ameloblastoma cell line demonstrated that HuR binds to ΔNp63 mRNA and stabilizes its expression. Genetic knockout of ΔNp63 increased E-cadherin expression, consistent with the reduced E-cadherin expression observed immunohistochemically in ΔNp63-positive budding areas. Histological examination of serial sections revealed bone remodeling at the tumor front, with newly formed bone surrounding tumor nests together with areas of bone resorption. These findings suggest that alterations in HuR, ΔNp63, and E-cadherin are associated with tumor budding and reduced epithelial cell-cell adhesion. Accompanying bone remodeling may complicate tumor removal and contribute to recurrence.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 9","pages":"e70178"},"PeriodicalIF":1.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Molecular Pathology of Morules in Endometrial Carcinoma: Biological Significance and Clinical Implications. 子宫内膜癌小痣的分子病理学：生物学意义和临床意义。

IF 1.9 4区医学

Pathology International Pub Date : 2026-08-01 DOI: 10.1111/pin.70168

Makoto Saegusa

{"title":"The Molecular Pathology of Morules in Endometrial Carcinoma: Biological Significance and Clinical Implications.","authors":"Makoto Saegusa","doi":"10.1111/pin.70168","DOIUrl":"10.1111/pin.70168","url":null,"abstract":"Morules were ordinally described as mulberry-like clusters of endometrial metaplasia with the potential to differentiate toward true squamous metaplasia (SqM). Although both morular and SqM lesions are categorized under \"endometrial carcinoma (Em Ca) with squamous differentiation\" in the WHO classification, they represent biologically distinct entities. Notably, morules are strongly associated with CTNNB1 (β-catenin) mutations. This review summarizes the molecular mechanisms driving the differentiation of Em Ca cells toward both morular and SqM phenotypes. Morules are frequently identified in younger Em Ca patients and display a unique immunophenotype characterized by nuclear β-catenin accumulation, a lack of expression of estrogen-α and progesterone receptor expression, and a low proliferative index. In Em Ca cells harboring CTNNB1 alterations, the PTEN/β-catenin axis suppresses cell proliferation and induces epithelial-to-mesenchymal transition, promoting morule-related cancer stem cell (CSC) properties. Conversely, p40 expression serves as the initial signaling event establishing SqM-related CSC features within the morule-SqM cascade. Furthermore, the ezrin-radixin-moesin-binding phosphoprotein 50/S100A4/myosin heavy chain 9 axis drives terminal squamous differentiation, particularly under hypoxic conditions. Clinically, histopathological evaluation of morular morphology and nuclear β-catenin status serves as a valuable tool for predicting progestin therapeutic efficacy in young Em Ca patients.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 8","pages":"e70168"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13521472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous Cell Carcinoma of the Uterine Cervix With Myxoid/Sarcomatoid Morphology. 宫颈鳞状细胞癌伴黏液样/肉瘤样形态。

IF 1.9 4区医学

Pathology International Pub Date : 2026-08-01 DOI: 10.1111/pin.70165

Kiho Yokoo, Kazuhito Tanaka, Tsuguharu Asato, Fumiko Yamamoto, Yoshiki Mikami

引用次数: 0

Utilization and Awareness of Japanese General Rules of Clinical and Pathological Recording of Cancers Among Japanese Pathologists: A Nationwide Questionnaire Survey. 日本病理学家对日本癌症临床和病理记录一般规则的使用和认识：一项全国性的问卷调查。

IF 1.9 4区医学

Pathology International Pub Date : 2026-08-01 DOI: 10.1111/pin.70162

Norihiro Teramoto, Reiko Watanabe, Ichiro Ito, Toyonori Tsuzuki

{"title":"Utilization and Awareness of Japanese General Rules of Clinical and Pathological Recording of Cancers Among Japanese Pathologists: A Nationwide Questionnaire Survey.","authors":"Norihiro Teramoto, Reiko Watanabe, Ichiro Ito, Toyonori Tsuzuki","doi":"10.1111/pin.70162","DOIUrl":"10.1111/pin.70162","url":null,"abstract":"The Japanese General Rules of Clinical and Pathological Reporting of Cancers (Kiyaku) are unique standardized systems for cancer handling and documentation used by professionals involved in cancer care in Japan. The Japanese Society of Pathology (JSP) conducted a questionnaire survey among practicing pathologists regarding the utilization and awareness of Kiyaku. We analyzed 1083 valid responses, representing 22.4% of the JSP members and 33.8% of the board-certified pathologists. Kiyaku, with > 90% latest-edition ownership, covered approximately 90% of all cancers in Japan. The timing of the implementation of the new editions varied not only across institutions but also among individuals in each institution. Among department directors, 46.1% reported implementing new editions at their discretion without prior notice. Item-level responses were collected for the stomach, lung, and breast as representative Kiyaku; histological classification and descriptive symbols were widely considered useful and frequently used across the three cancers, whereas biopsy-related items in the lung and breast were used less frequently. In conclusion, Kiyaku is broadly embedded in daily practice and facilitates standardized cancer documentation in Japan, although several challenges remain. The JSP should clearly articulate the purpose of Kiyaku and promote coordinated adoption to standardize its use in pathology practice.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 8","pages":"e70162"},"PeriodicalIF":1.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0