Pathology International最新文献_第3页

An autopsy case report of amyotrophic lateral sclerosis with unusual basophilic inclusions exhibiting immunopositivity for optineurin. 肌萎缩性侧索硬化症的尸检病例报告与不寻常的嗜碱性包体显示免疫阳性的优神经蛋白。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-11 DOI: 10.1111/pin.13501

Mayu Kashiwagi-Hakozaki, Masako Ikemura, Hiroya Naruse, Yuji Takahashi, Tatsushi Toda, Tetsuo Ushiku

引用次数: 0

SMARCB1-deficient malignant neoplasm of the pancreas with heterogeneous morphologies that cannot be classified into existing histologic types. SMARCB1缺陷型胰腺恶性肿瘤，形态不一，无法归入现有组织学类型。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1111/pin.13489

Yusuke Kouchi, Nozomu Sakai, Sakurako Harada-Kagitani, Ryotaro Eto, Takashi Mishima, Shigetsugu Takano, Katsuhiro Nasu, Jun-Ichiro Ikeda, Masayuki Ohtsuka, Takashi Kishimoto

{"title":"SMARCB1-deficient malignant neoplasm of the pancreas with heterogeneous morphologies that cannot be classified into existing histologic types.","authors":"Yusuke Kouchi, Nozomu Sakai, Sakurako Harada-Kagitani, Ryotaro Eto, Takashi Mishima, Shigetsugu Takano, Katsuhiro Nasu, Jun-Ichiro Ikeda, Masayuki Ohtsuka, Takashi Kishimoto","doi":"10.1111/pin.13489","DOIUrl":"10.1111/pin.13489","url":null,"abstract":"A 50-year-old male with a pancreatic tail tumor underwent distal pancreatectomy. At 14 and 27 months after the primary surgery, metachronous liver metastases were identified and partial hepatectomies were performed for each. Pathologic findings of the primary pancreatic tumor were heterogeneous, but they essentially categorized into two components based on their cytologic features: (i) clear cell component and (ii) epithelioid cell component. The metastatic hepatic tumor was entirely composed of the epithelioid cell component. SMARCB1 expression was lost by immunohistochemistry and heterozygous deletion of SMARCB1 was identified by fluorescence in situ hybridization for both the primary and metastatic tumors. Targeted DNA sequencing of a metastatic hepatic tumor sample was performed and SMARCB1 loss was identified. Based on the morphologic, immunohistochemical, and molecular analyzes, the present case was difficult to classify into any of the existing entities. SMARCB1 deficiency might play a key role in the tumorigenesis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"691-696"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widespread benign HNF1β-positive solid nests from the urethral diverticulum to the bladder neck: Is it a mesonephric remnant? 从尿道憩室到膀胱颈的广泛良性HNF1β阳性实性巢：是肾间质残余吗？

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1111/pin.13486

Takahiro Kirisawa, Akiko Miyagi Maeshima, Tomoya Okuno, Ayumu Matsuda, Yoshiyuki Matsui

引用次数: 0

Brain biopsy and pathological diagnosis for drug-associated progressive multifocal leukoencephalopathy (PML) with inflammatory reactions. 与药物相关的伴有炎症反应的进行性多灶性白质脑病（PML）的脑活检和病理诊断。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1111/pin.13492

Yukiko Shishido-Hara

{"title":"Brain biopsy and pathological diagnosis for drug-associated progressive multifocal leukoencephalopathy (PML) with inflammatory reactions.","authors":"Yukiko Shishido-Hara","doi":"10.1111/pin.13492","DOIUrl":"10.1111/pin.13492","url":null,"abstract":"Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by JC virus (JCV) infection. Although recognized as an AIDS complication in the 1980s, PML has emerged as a serious adverse event of immunosuppressive therapies since 2005, particularly disease-modifying drugs (DMDs) for multiple sclerosis (MS). PML can also occur in patients with collagenous diseases receiving steroid therapy or with age-related immunosuppression. In some cases, the etiology of immunosuppression remains unclear. These cases often present with early manifestations of PML, which, while common, are less well recognized, as PML was identified at more advanced stages in AIDS-related cases. Early diagnosis poses difficulty due to unfamiliar magnetic resonance (MR) images and low viral loads in cerebrospinal fluid (CSF), and brain biopsy may be conducted. This review summarizes the PML pathology identified through biopsy. Early cytopathological changes of JCV-infected cells, with the importance of dot-shaped inclusions associated with promyelocytic leukemia nuclear bodies (PML-NBs), are described. The variability of host immune responses, including PML immune reconstitution inflammatory syndrome (PML-IRIS), is addressed. The potential role of immune checkpoint inhibitors (ICIs), such as pembrolizumab, is also explored. Understanding the pathology of early PML helps to optimize diagnostic strategies and therapeutic interventions, ultimately improving prognosis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"673-681"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11636588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMARCB1-deficient renal medullary carcinoma with an EML4::ALK fusion gene in a Japanese woman. 一名日本女性患上带有 EML4::ALK 融合基因的 SMARCB1 缺失型肾髓质癌。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1111/pin.13494

Megumi Nobuoka, Tatsuya Mukawa, Mai Iwaya, Shohei Shigeto, Tomonori Minagawa, Takeshi Uehara, Yoshiyuki Akiyama

引用次数: 0

Multifocal meningoencephalitis after vaccination against COVID-19. 接种 COVID-19 疫苗后出现多灶性脑膜脑炎。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1111/pin.13491

Shuji Mikami, Mitsuru Ishii, Tetsuhiro Yano, Ichiro Hirayama, Yuichiro Hayashi, Takayuki Shiomi, Yoshiteru Tominaga, Tsuyoshi Ishida

{"title":"Multifocal meningoencephalitis after vaccination against COVID-19.","authors":"Shuji Mikami, Mitsuru Ishii, Tetsuhiro Yano, Ichiro Hirayama, Yuichiro Hayashi, Takayuki Shiomi, Yoshiteru Tominaga, Tsuyoshi Ishida","doi":"10.1111/pin.13491","DOIUrl":"10.1111/pin.13491","url":null,"abstract":"We report the case of an 84-year-old male patient who was transferred to our hospital because of impaired consciousness and high fever, and died about 10 weeks after his fourth \"coronavirus disease 2019\" (COVID-19) vaccination. Autopsy revealed acute ischemic change with microhemorrhage and perivascular T-cell infiltration in the thalamus, pons, and cerebellum, which were considered to be related to neurological symptoms. There were dilatation of the right ventricle, accumulation of pleural effusion, and ascites, suggesting right heart failure. Although the patient had a negative COVID-19 polymerase chain reaction test, immunohistochemical analysis for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens (spike and nucleocapsid proteins) was performed to identify the cause of death. Surprisingly, only SARS-CoV-2 spike protein was detected in the thalamus, pons, and pituitary and adrenal glands. The presence of SARS-CoV-2 spike protein might have been due to vaccination rather than viral infection, because no SARS-CoV-2 nucleocapsid protein was detected. The spike protein in the central nervous system might have been related to the acute ischemic change, and that in the pituitary and adrenal glands may have been associated with right heart failure, possibly through dysfunction of the renin-angiotensin-aldosterone system.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"697-703"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What is the role of membrane-located epithelial cell transforming sequence 2 at the interphase of lung adenocarcinoma cells? 膜定位上皮细胞转化序列 2 在肺腺癌细胞间期的作用是什么？

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2023-12-20 DOI: 10.1111/pin.13397

Yoshihiko Murata, Ai Yoshida, Yuko Minami, Zeinab Kosibaty, Daisuke Matsubara, Masayuki Noguchi

引用次数: 0

GATA3 expression in tumor-infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo-ovarian carcinomas. 肿瘤浸润单核炎症细胞中 GATA3 的表达与输卵管卵巢癌的不良预后因素有关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI: 10.1111/pin.13488

Fatemeh Nili, Elham Mirzaian, Tahereh Doustmohammadi, Somayeh Moradpanah, Fereshteh Ameli, Soheila Sarmadi, Niusha Momeni

{"title":"GATA3 expression in tumor-infiltrating mononuclear inflammatory cells is associated with poor prognostic factors in tubo-ovarian carcinomas.","authors":"Fatemeh Nili, Elham Mirzaian, Tahereh Doustmohammadi, Somayeh Moradpanah, Fereshteh Ameli, Soheila Sarmadi, Niusha Momeni","doi":"10.1111/pin.13488","DOIUrl":"10.1111/pin.13488","url":null,"abstract":"The study investigated the expression of GATA3, a transcription factor involved in immune regulation, in tubo-ovarian carcinomas and its association with clinicopathological factors and prognosis. Immunohistochemical analysis was performed on 91 tubo-ovarian carcinoma samples to determine the presence of GATA3-positive inflammatory cells in the tumor microenvironment. A threshold of 10% or higher was considered a positive expression. The results showed that 46.7% of tubo-ovarian carcinomas exhibited positive expression of GATA3 in inflammatory cells. There was no significant difference in GATA3 expression between patients who received pre-surgical chemotherapy and those who underwent primary surgery. However, high-grade serous carcinomas had a significantly higher proportion of GATA3-positive inflammatory cells compared to other subtypes. Advanced-stage tumors (stage III) had a higher percentage of GATA3-positive inflammatory cells compared to stage II and I tumors. Patients with positive GATA3 expression had a significantly lower disease-free survival rate. However, there was no significant association between GATA3 expression and chemotherapy response score. These findings suggest that increased expression of GATA3 in mononuclear inflammatory cells is associated with higher grade, advanced stage, and increased risk of recurrence in tubo-ovarian carcinoma. This implies that heightened GATA3 expression negatively impacts anti-tumor immunity, tumor growth progression, and invasiveness in tubo-ovarian carcinomas.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"682-690"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues. 尸检一例伴有唐氏综合征的短暂性骨髓增生异常的死产：胎盘组织中GATA1突变的免疫组织化学证明。

IF 2.5 4区医学

Pathology International Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI: 10.1111/pin.13497

Sanae Yamazaki, Jun Miyauchi, Hideaki Sato, Yuko Takahashi, Takayuki Amikura

{"title":"Autopsy case of a stillbirth with transient abnormal myelopoiesis associated with Down syndrome: Immunohistochemical demonstration of GATA1 mutation in placental tissues.","authors":"Sanae Yamazaki, Jun Miyauchi, Hideaki Sato, Yuko Takahashi, Takayuki Amikura","doi":"10.1111/pin.13497","DOIUrl":"10.1111/pin.13497","url":null,"abstract":"Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) exhibits hematological features that are indistinguishable from those of acute megakaryoblastic leukemia. However, TAM typically resolves spontaneously within several months postnatally. Some patients with TAM, however, develop severe clinical manifestations, which can lead to an unfavorable prognosis. TAM originates in utero through the acquisition of somatic GATA1 mutations, resulting in the loss of the full-length GATA1 protein and excessive production of the N-terminal truncated short isoform of the GATA1 protein (GATA1s). Herein, we report the pathological findings from an autopsy of a female stillbirth with TAM and DS, including an examination of her placental tissues. Immunohistochemical analysis revealed the expression of GATA1s, but not full-length GATA1, in CD42b-positive atypical immature megakaryocytes and blasts in the placental blood vessels. This confirms the diagnosis of TAM and suggests the utility of placental tissue for histological diagnosis. Additional unique findings from the autopsy specimens are discussed.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"708-713"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of A Presentation by the winners of The Japanese Society of Pathology, Pathology Research Award in 2024 (in program order). 2024 年日本病理学会病理学研究奖获奖者演讲摘要（按节目顺序排列）。

IF 2.5 4区医学

Pathology International Pub Date : 2024-11-01 DOI: 10.1111/pin.13481

引用次数: 0