Pathology International最新文献_第3页

Unexpected Autopsy Case of Placental Transmogrification of the Lung With Lipomatous Change With Detailed Immunohistochemical Analysis. 肺胎盘变形伴脂肪瘤改变的意外尸检病例及详细的免疫组织化学分析。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1111/pin.70031

Ryo Kaimori, Haruto Nishida, Riko Kubota Furukawa, Kazuhiro Kawamura, Mari Tamura, Kohji Kuroki, Shinji Yano, Kumi Murata, Tsutomu Daa, Shinjiro Mori

{"title":"Unexpected Autopsy Case of Placental Transmogrification of the Lung With Lipomatous Change With Detailed Immunohistochemical Analysis.","authors":"Ryo Kaimori, Haruto Nishida, Riko Kubota Furukawa, Kazuhiro Kawamura, Mari Tamura, Kohji Kuroki, Shinji Yano, Kumi Murata, Tsutomu Daa, Shinjiro Mori","doi":"10.1111/pin.70031","DOIUrl":"10.1111/pin.70031","url":null,"abstract":"Placental transmogrification of the lung (PTL) is a rare cystic lesion characterized by a distinctive microscopic architecture resembling placental villi. Although its etiology remains unclear, PTL is frequently observed with emphysema, suggesting a potential association between these conditions. However, the precise nature of this relationship remains ambiguous, and whether PTL causes or results from emphysema remains unclear. This report presents an incidental finding of PTL without macroscopic emphysematous changes with detailed immunohistochemical and ultrastructural analysis. A 58-year-old man died from aspiration pneumonia due to methanol poisoning. Autopsy revealed pyothorax in the right lung cavity and hemorrhage in the bilateral putamen. Although the left lung showed no severe inflammatory changes, a white-yellowish granular lesion was observed. Histopathologically, the lesion demonstrated villi-like structures with interstitial adipocyte infiltration, without evidence of hamartomatous component, such as cartilage or smooth muscle. Thus, the lesion was diagnosed as PTL with lipomatous change. PTL is typically associated with emphysematous/cystic lesions and is often considered reactive due to these. Herein, the lesion was surrounded by microscopic emphysema, suggesting an early-stage PTL that may have contributed to the development of emphysematous changes. This report describes the PTL with detailed immunohistochemical analysis.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"425-430"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine Mesenchymal Neoplasm With a Novel CDC42::PLAG1 Fusion. 子宫间质肿瘤与新型CDC42::PLAG1融合。

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-07-03 DOI: 10.1111/pin.70035

Pranav Dorwal, Diarmid Foulis, Jing Jing Li, Michael Burling, Lyndal Anderson

引用次数: 0

High Frequency of RhoGAP Fusion and Muscularis Mucosae Invasion in pT1a Gastric Adenocarcinoma Harboring Lymph Node Metastasis. 伴有淋巴结转移的pT1a型胃腺癌RhoGAP融合及黏膜肌层浸润的高频率研究

IF 3.4 4区医学

Pathology International Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1111/pin.70032

Chiina Hata, Hiroto Noda, Kaoru Nakano, Seiji Sakata, Kazuma Moriya, Satoko Baba, Toshiaki Hirasawa, Manabu Takamatsu, Emiko Sugawara, Noriko Yamamoto, Souya Nunobe, Takuji Gotoda, Kenichi Ohashi, Kengo Takeuchi, Hiroshi Kawachi

{"title":"High Frequency of RhoGAP Fusion and Muscularis Mucosae Invasion in pT1a Gastric Adenocarcinoma Harboring Lymph Node Metastasis.","authors":"Chiina Hata, Hiroto Noda, Kaoru Nakano, Seiji Sakata, Kazuma Moriya, Satoko Baba, Toshiaki Hirasawa, Manabu Takamatsu, Emiko Sugawara, Noriko Yamamoto, Souya Nunobe, Takuji Gotoda, Kenichi Ohashi, Kengo Takeuchi, Hiroshi Kawachi","doi":"10.1111/pin.70032","DOIUrl":"10.1111/pin.70032","url":null,"abstract":"Gastric cancer (GC) confined to the mucosa (pT1a-GC) has a low incidence (approximately 3%) of lymph node metastasis (LNM), making it a suitable candidate for endoscopic resection. However, the current risk stratification system inadequately identifies high-risk patients. Although RhoGAP fusion has been identified as a risk factor for LNM in pT1b-GC, its role in pT1a-GC remains unclear. In the present study, medical records of 1099 surgically resected pT1a-GC cases over 12 years were reviewed, identifying 33 cases (3.0%) with LNM. A case-control study compared these cases to 99 LNM-negative cases based on clinicopathological data. Histological reviews and fluorescence In Situ hybridization assays to evaluate RhoGAP fusions, represented by CLDN18::ARHGAP26, were conducted. Univariate analysis revealed significant associations between LNM and larger tumor size (> 30 mm), mixed histological type, muscularis mucosae invasion (MMI), microtubular-mucocellular histology, and RhoGAP fusion. Multivariate analysis identified RhoGAP fusion and MMI as independent LNM predictors. Among LNM-positive cases, RhoGAP fusion was observed in 51.5% (17/33) and was associated with younger age and less frequent MMI. In conclusion, RhoGAP fusion and MMI may be significant biomarkers for LNM in pT1a-GC. Incorporating these factors could enhance risk stratification and inform clinical management strategies for pT1a-GC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"414-424"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological Significance of Spread Through Air Spaces in Lung Cancer. 肺癌经气道扩散的临床病理意义。

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-22 DOI: 10.1111/pin.70037

Emi Ibuki, Chihiro Yoshida, Kyuichi Kadota

引用次数: 0

The Significance of Cytoplasmic STAT6 Positivity and High p53/p16 Expression as a Novel Predictor of Histological/Clinical Malignancy in NAB2::STAT6 Fusion-Positive Orbital Solitary Fibrous Tumors. 细胞质STAT6阳性和p53/p16高表达作为NAB2::STAT6融合阳性眼眶孤立性纤维性肿瘤组织学/临床恶性肿瘤的新预测因子的意义

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-17 DOI: 10.1111/pin.70036

Satoshi Adachi, Akihide Kondo, Ikuko Ogino, Mario Suzuki, Yuzaburo Shimizu, Osamu Akiyama, Takuo Hayashi, Arata Tomiyama

{"title":"The Significance of Cytoplasmic STAT6 Positivity and High p53/p16 Expression as a Novel Predictor of Histological/Clinical Malignancy in NAB2::STAT6 Fusion-Positive Orbital Solitary Fibrous Tumors.","authors":"Satoshi Adachi, Akihide Kondo, Ikuko Ogino, Mario Suzuki, Yuzaburo Shimizu, Osamu Akiyama, Takuo Hayashi, Arata Tomiyama","doi":"10.1111/pin.70036","DOIUrl":"https://doi.org/10.1111/pin.70036","url":null,"abstract":"Orbital solitary fibrous tumor (SFT) is an extremely rare variant of systemic SFTs. However, the relationship between the biological/clinical characteristics, histological malignancies, and known oncogenes of systemic SFTs has not yet been elucidated. Therefore, we investigated these features and explored the prognostic factors of orbital SFTs by analyzing a series of orbital SFT cases. Six orbital SFT and one meningeal SFT were analyzed for comparison. NAB2::STAT6 variants were identified in five of the six orbital SFTs cases and one meningeal SFT case. There was no correlation between the exon composition of NAB2::STAT6 variants and the time of relapse after surgery or histological malignancy. Nuclear STAT6 staining by immunohistochemistry was observed in all cases, whereas cytosolic STAT6 staining was confirmed in three orbital SFT cases. The presence of histological malignancies and positive cytosolic STAT6 staining were mutually exclusive. The diffuse strong expressions of p53 and p16 were confirmed only in a case with the worst clinical course. No TERT promoter mutations were observed in any of these cases. Our study suggests that positivity of cytosolic STAT6 staining and high p53/p16 expression may be a predictor of histological/clinical malignancy in orbital SFT. Further evidence is necessary to confirm our results.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Pathological Autopsy in Japan From 1958 to 2023. 1958 - 2023年日本病理尸检趋势

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-16 DOI: 10.1111/pin.70038

Hiroshi Uozaki, Yoshinao Kikuchi, Masato Watanabe

{"title":"Trends in Pathological Autopsy in Japan From 1958 to 2023.","authors":"Hiroshi Uozaki, Yoshinao Kikuchi, Masato Watanabe","doi":"10.1111/pin.70038","DOIUrl":"https://doi.org/10.1111/pin.70038","url":null,"abstract":"Pathological autopsies are essential for medical education and medical progress, yet their numbers have been declining globally. Annual of the Pathological Autopsy Cases in Japan (APAC-J), established in 1958, is a comprehensive nationwide database of autopsies performed in Japan. This study analyzed APAC-J data from 1958 to 2023, encompassing over 1.49 million cases. The number of autopsies peaked at 40,680 in 1985 but declined significantly to 10,020 in 2019, and further to 6,557 in 2022 largely due to the COVID-19 pandemic. Autopsy rates declined after the medical school conflicts in the late 1960s, with temporary increases following the introduction of board certification for pathologists. The number of data-reporting facilities rose to 934 by 2019. Since 2000, the proportion of brain dissections has slightly increased, while limited autopsies have decreased (24% and 3.9%, respectively, in 2023). The male-to-female ratio is over 2.0, and average ages of autopsy cases remain over 10 years younger than Japanese life expectancy. Autopsy rates were higher among individuals from childhood to middle age. This study demonstrates that social dynamics and healthcare system reforms have influenced autopsy practices. Interpretation of autopsy case groups must consider demographic characteristics and shifts in autopsy implementation over time.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric Neuroendocrine Tumor With Pancreatic Acinar Cell Differentiation in the Background of Atrophic Gastritis: A Possible Variant of Type 1 ECL-Cell NET-A Case Report. 萎缩性胃炎背景下胃神经内分泌肿瘤伴胰腺腺泡细胞分化：1型ecl细胞NET-A可能的变异病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1111/pin.70022

Tomoko Norose, Nobuyuki Ohike, Misato Tsukada, Yoshiya Sugiura, Hirotaka Koizumi, Yusuke Nakamoto, Keisuke Tateishi, Shinya Mikami, Junki Koike

{"title":"Gastric Neuroendocrine Tumor With Pancreatic Acinar Cell Differentiation in the Background of Atrophic Gastritis: A Possible Variant of Type 1 ECL-Cell NET-A Case Report.","authors":"Tomoko Norose, Nobuyuki Ohike, Misato Tsukada, Yoshiya Sugiura, Hirotaka Koizumi, Yusuke Nakamoto, Keisuke Tateishi, Shinya Mikami, Junki Koike","doi":"10.1111/pin.70022","DOIUrl":"10.1111/pin.70022","url":null,"abstract":"A gastric neuroendocrine tumor (NET) with pancreatic acinar cell differentiation is extremely rare. We report the case of an 87-year-old woman with a submucosal tumor in the gastric body on a background of atrophic gastritis. She also had Sjögren's syndrome. Initially 17.8 × 6.5 mm, the tumor enlarged over 10 years, leading to wedge resection. The resected mass (45 × 40 × 30 mm) was solid with a pale yellow to gray-white cut surface. Histologically, it showed trabecular or solid nests of epithelial cells with round nuclei and eosinophilic cytoplasm. Immunohistochemistry showed positivity for CKAE1/3, VMAT2, neuroendocrine markers, and pancreatic acinar markers. Ki-67 index was 11.2%. The tumor co-expressed PDX1 and ARX and showed loss of menin and ATRX. These findings support a diagnosis of gastric ECL-cell NET G2 arising in autoimmune gastritis, with secondary pancreatic acinar differentiation. This tumor may represent a variant of type 1 gastric NET.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"359-365"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMARCB1-Deficient Pulmonary Mesenchymal Tumor Without Malignant Histological Features. 无恶性组织学特征的缺乏smarcb1的肺间充质肿瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-01 Epub Date: 2025-05-16 DOI: 10.1111/pin.70025

Nozomi Nakajima, Kohei Fukuoka, Seshiru Nakazawa, Yoichi Ohtaki, Nozomi Matsumura, Ayako Yamazaki, Hideaki Yokoo, Akihiko Yoshida, Sumihito Nobusawa

引用次数: 0

Clinicopathological Characterization of Squamous Cell Lung Carcinoma Adjacent to Emphysema. 肺鳞状细胞癌伴肺气肿的临床病理特征。

IF 2.5 4区医学

Pathology International Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.1111/pin.70023

Tetsuya Sakai, Hibiki Udagawa, Hiroki Izumi, Shigeki Umemura, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Naito Tomoyuki, Nakai Tokiko, Tetsuro Taki, Naoya Sakamoto, Shingo Sakashita, Motohiro Kojima, Masahiro Tsuboi, Koichi Goto, Genichiro Ishii

{"title":"Clinicopathological Characterization of Squamous Cell Lung Carcinoma Adjacent to Emphysema.","authors":"Tetsuya Sakai, Hibiki Udagawa, Hiroki Izumi, Shigeki Umemura, Yoshitaka Zenke, Shingo Matsumoto, Kiyotaka Yoh, Naito Tomoyuki, Nakai Tokiko, Tetsuro Taki, Naoya Sakamoto, Shingo Sakashita, Motohiro Kojima, Masahiro Tsuboi, Koichi Goto, Genichiro Ishii","doi":"10.1111/pin.70023","DOIUrl":"10.1111/pin.70023","url":null,"abstract":"The study investigated the clinicopathological features and characteristic immune tumor microenvironment (TME) of lung squamous cell carcinoma (SqCC) adjacent to emphysematous lesions. 184 consecutive patients with peripheral-type SqCC who had undergone complete surgical resection were enrolled. The clinicopathological differences between emphysema-adjacent SqCC (EA-SqCC) and non-emphysema-adjacent SqCC (non-EA-SqCC) were examined. The immune TME, including tumor-infiltrating lymphocytes (TILs) and PD-L1 expression, was also analyzed. EA-SqCC was detected in 132 (71.7%) of the 184 patients. Patients with EA-SqCC had shorter recurrence-free survival (RFS) [median 58.2 months vs. not Reached (NR); hazard ratio (HR) 0.47; 95% CI 0.25-0.81, p < 0.01] and tended to have shorter overall survival (NR vs. NR; HR 0.47; 95% CI 0.27-1.03, p = 0.07) compared to patients with non-EA-SqCC. Evaluation of TILs in the cancer stroma showed the number of Foxp3+ TILs in the EA-SqCC group was significantly higher than that in the non-EA-SqCC group (median number 58 vs. 43, p < 0.01). However, there were no significant differences in the number of CD8 + T cells and the PD-L1 expression between the two groups. Immunosuppressive microenvironment is a characteristic feature of EA-SqCC, which may contribute to the poor prognosis of this disease.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"329-339"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA Degradation in FFPE Tissue Samples Caused by Air Transport: An Experimental Evaluation of Radiation Exposure. 航空运输引起的FFPE组织样品中的DNA降解：辐射暴露的实验评估。

IF 3.4 4区医学

Pathology International Pub Date : 2025-07-01 Epub Date: 2025-06-03 DOI: 10.1111/pin.70027

Rio Yamaguchi, Takahiro Yamane, Masahiro Oita, Hirofumi Inoue, Mizuki Morita

引用次数: 0