Pathology International最新文献_第3页

Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer.

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1111/pin.13510

Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue

{"title":"Combined use of immunoreactivities of Efp and ZCCHC3 for predicting prognosis of patients with triple-negative breast cancer.","authors":"Akihiro Fujimoto, Kazuhiro Ikeda, Keiichi Kinowaki, Takuya Ogura, Toshihiko Takeiwa, Hidetaka Kawabata, Akihiko Osaki, Kuniko Horie, Satoshi Inoue","doi":"10.1111/pin.13510","DOIUrl":"10.1111/pin.13510","url":null,"abstract":"We previously reported that strong immunoreactivity (IR) of estrogen-responsive finger protein (Efp), also known as tripartite motif-containing 25 (TRIM25), predicts poor prognosis in patients with estrogen receptor-positive and -negative invasive breast cancers. In the present study, we investigated the clinicopathological role of Efp and ZCCHC3, the latter of which is an Efp interactor, in a triple-negative breast cancer (TNBC) cohort which was composed of 118 Japanese female breast cancer patients underwent surgical treatment. Efp and ZCCHC3 IRs were analyzed using specific antibodies for these proteins. We demonstrated that positive Efp IR was significantly associated with shorter distant disease-free survival (p = 0.0108) and that positive ZCCHC3 IR was also significantly associated with shorter distant disease-free survival (p = 0.0153). Notably, ZCCHC3 IR was positively associated with Efp IR (p = 0.003). When IRs of the two proteins were combined, double positivity was associated with shorter distant disease-free survival (p = 0.0007) and was an independent factor for poor prognosis. These results suggest that IR positivity of Efp and ZCCHC3 has clinical significance as a poor prognostic factor in patients with TNBC. Thus, we propose that the combined use of both IRs can be used as a prognostic marker for TNBC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"92-99"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy. 腱鞘炎伴炎性钙化--扫描电子显微镜和能量色散 X 射线光谱分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1111/pin.13502

Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi

{"title":"Tenosynovitis with psammomatous calcification-Analysis by scanning electron microscopy and energy-dispersive x-ray spectroscopy.","authors":"Yuta Sonobe, Hiromasa Hasegawa, Kazuaki Hashimoto, Hisatake Takamiya, Yuka Yamawaki, Eiichi Konishi","doi":"10.1111/pin.13502","DOIUrl":"10.1111/pin.13502","url":null,"abstract":"Tenosynovitis with psammomatous calcification (TPC) is an extremely rare condition. It was first described as a characteristic subtype of idiopathic calcifying tenosynovitis, with only 40 cases reported to date. Here, we present a case of TPC affecting a female patient in her late teens, with no relevant medical history. She presented with discomfort and pain in the right first toe. A 10-mm mushroom-like calcified mass was observed in the metatarsophalangeal joint on radiographs. The surgical specimen revealed chronic synovitis with calcification. Numerous psammomatous bodies are observed in the synovium, often with granulomatous reactions. After removal of the mass, no recurrence has been observed for 5 years. Although the etiology of TPC has been suggested to be related to repetitive trauma to the tendon or peritendinous soft tissue, the composition and mechanism of calcification remain unclear because of its rarity. In this report, we also discuss the calcification mechanism in TPC, supported by scanning electron microscopy and energy-dispersive x-ray spectroscopy findings.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"100-104"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myxoid spindle cell tumor with EWSR1-CREM fusion mimicking papillary adenoma of the lung.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13517

Yurie Okayama, Shin Ishizawa, Akane Aikawa, Yuko Nakanishi, Akio Uchiyama, Tomohiko Takahashi, Yasushi Yatabe

引用次数: 0

Atypical choroid plexus papilloma arising in a mature ovarian teratoma, a case report.

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-27 DOI: 10.1111/pin.13513

Brandon Gehris, Songlin Zhang, Xiaohong Iris Wang

引用次数: 0

Keratin-derived amyloid deposition associated with silicone granuloma in an older adult: Comprehensive analysis using immunohistochemistry, proteomics, and a literature review. 与一名老年人硅肉芽肿相关的角蛋白源性淀粉样沉积：利用免疫组化、蛋白质组学和文献综述进行综合分析。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1111/pin.13490

Shojiro Ichimata, Tomochika Kuroda, Tsuneaki Yoshinaga, Mitsuto Sato, Nagaaki Katoh, Fuyuki Kametani, Suzuho Onagi, Masahide Yazaki, Yoshiki Sekijima, Shin Ishizawa

引用次数: 0

Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations. BRAF和NRAS突变的软组织肿瘤与ntrk重排梭形细胞肿瘤具有共同的特征：一例报告扩大了激酶基因改变的梭形细胞肿瘤的谱。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-06 DOI: 10.1111/pin.13499

Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi

{"title":"Soft tissue tumor with BRAF and NRAS mutations sharing features with NTRK-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations.","authors":"Yuko Kakuda, Ikuma Kato, Takuya Kawata, Keisuke Goto, Kan Ito, Ryo Satake, Shunichi Toki, Hideki Murata, Junji Wasa, Hirohisa Katagiri, Mitsuru Takahashi, Takeshi Nagashima, Taro Mori, Yoshinao Oda, Takashi Sugino, Ken Yamaguchi","doi":"10.1111/pin.13499","DOIUrl":"10.1111/pin.13499","url":null,"abstract":"NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"40-45"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report. 前纵隔成熟囊性畸胎瘤引发的分泌性腺癌：病例报告。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1111/pin.13495

Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki

{"title":"Apocrine adenocarcinoma arising from mature cystic teratoma in the anterior mediastinum: A case report.","authors":"Takuya Ueda, Kazuya Takamochi, Taichiro Yoshimoto, Tomohiro Ichikawa, Takeshi Matsunaga, Takuo Hayashi, Kenji Suzuki","doi":"10.1111/pin.13495","DOIUrl":"10.1111/pin.13495","url":null,"abstract":"Primary mediastinal apocrine adenocarcinoma is extremely rare, with only one case reported to date. Here, we report a surgical case of primary mediastinal apocrine adenocarcinoma. An anterior mediastinal cystic tumor with calcification was identified on chest computed tomography scan in a 51-year-old female patient undergoing maintenance hemodialysis. The tumor was 19 mm in size, did not invade the adjacent organs or show distant metastases, and was surgically removed. Microscopic examination revealed that the tumor cells exhibited cribriform or solid proliferation patterns with thick fibrous capsules. The tumor cells had an abundant eosinophilic cytoplasm, and decapitation secretion was noted. Immunohistochemistry revealed positivity for GCDFP-15 and androgen receptors, with Ki-67 positivity at 10%. The cyst wall exhibited extensive fibrosis and keratinized material, with bone and bronchial glands identified at the cyst periphery; the tumor cells were contiguous with those structures. The patient was diagnosed with apocrine adenocarcinoma arising from a mature cystic teratoma. The patient has maintained a recurrence-free status without adjuvant therapy for 6 years after surgery. This case presents a small primary mediastinal apocrine adenocarcinoma that achieved remarkable long-term survival.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"34-39"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging. 基于多光子激发成像非标记分析的光学组织病理学。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13498

Takahiro Matsui

{"title":"Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.","authors":"Takahiro Matsui","doi":"10.1111/pin.13498","DOIUrl":"10.1111/pin.13498","url":null,"abstract":"Histopathological diagnosis is the definitive method for the evaluation of disease status; however, some problems need to be solved, such as invasiveness, time consumption, and difficulty in three-dimensional observation. To overcome these problems, a novel observation method, distinct from conventional histology, using tissue sections and glass slides is desirable. Fluorescence imaging of human tissues with multiphoton excitation imaging (MpEI), which was originally used for intravital imaging in biological research, is a promising method. Label-free MpEI, which requires only near-infrared excitation, can construct images with autofluorescent signals from fresh tissues, as well as nonlinear optical phenomena. It is possible to perform real-time three-dimensional imaging of human tissues without any tissue removal, fixation, or staining. This method has been reported to be useful for histopathological classification in multiple organs and tissues. Moreover, it is very compatible with quantitative image analyses, including artificial intelligence. Based on these characteristics, label-free MpEI has sufficient potential for clinical applications such as in endoscopy and intraoperative rapid diagnosis. The clinical application of label-free MpEI will bring changes not only to histopathology examination but also the clinical bedside and will contribute to the further development of histopathology.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian mucinous cystic tumor with an overwhelming fundic gland differentiation. 卵巢粘液性囊肿伴有压迫性底腺分化。

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1111/pin.13493

Satoe Numakura, Yuko Sasajima, Teppei Morikawa, Takayuki Ichinose, Kazunori Nagasaka, Masahiro Kato, Hiroshi Uozaki

引用次数: 0

Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation. 中枢神经系统原发性大b细胞淋巴瘤：基于临床、病理和分子评价的cd5阳性病例的重新评估

IF 2.5 4区医学

Pathology International Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1111/pin.13496

Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura

{"title":"Primary large B-cell lymphoma of the central nervous system: A reappraisal of CD5-positive cases based on clinical, pathological, and molecular evaluation.","authors":"Seiji Yamada, Akira Satou, Yuta Tsuyuki, Sachiko Iba, Yuka Okumura, Eri Ishikawa, Hideaki Ito, Yasunori Kogure, Naoe Goto, Motoki Tanikawa, Kazuyuki Shimada, Tetsuya Tsukamoto, Kennosuke Karube, Hideaki Yokoo, Keisuke Kataoka, Akihiro Tomita, Mitsuhito Mase, Shigeo Nakamura","doi":"10.1111/pin.13496","DOIUrl":"10.1111/pin.13496","url":null,"abstract":"CD5 expression is seen in 5%-10% of de novo diffuse large B-cell lymphomas (DLBCLs). Primary large B-cell lymphoma of the central nervous system (PCNS-LBCL) also exhibits CD5 expression in a minority of cases, however, clinicopathological and molecular features remain largely unclarified. Here we present the clinical, molecular, and pathological features of 11 CD5-positive (+) PCNS-LBCL cases, occupying 6.7% of all 165 PCNS-LBCLs diagnosed in our institutions. While CD5+ systemic DLBCL has been recognized as a distinctive subgroup showing an aggressive clinical course, no obvious differences were found between CD5+ and CD5-negative subgroups among the present CNS patients clinically. MYD88 p.L265P and CD79B p.Y196 mutations were detected in eight (73%) and seven (64%) cases, respectively, supporting previous reports. Notably, the microenvironmental immune cells were universally PD-L1/CD274-positive, and the higher levels tended to present favorable overall survival, as already evidenced in the PCNS-LBCL series. In contrast, neoplastic PD-L1/CD274 expression was undetectable in all cases. Indeed, no structural variations or copy number alterations involving PD-1 ligands were detected by targeted-capture sequencing and fluorescence in situ hybridization. While further studies are warranted, we may have confirmed similarity between PCNS-LBCLs and intravascular large B-cell lymphomas from a molecular standpoint.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"11-20"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0