Germinomas: Nestin and CD15 Expression in Tumor Blood Vessels.

IF 3.4 4区医学 Q2 PATHOLOGY

Pathology International Pub Date : 2025-09-16 DOI:10.1111/pin.70050

Carlos Alcalá-Romero, Ana Laura Calderón-Garcidueñas, Sanjuana Berenice Treviño-Solís, Carlos Eduardo Dieguez-Campa, Rebeca Ramos-Sánchez

引用次数: 0

Abstract

Germinomas constitute two-thirds of intracranial germ cell neoplasms, with a woman: male ratio of 8:22. A characteristic of this tumor is its adequate vascularity, which has not been previously studied with markers such as Nestin, YAP and CD15, and which can provide valuable information about the biology of this tumor. These markers were analyzed by immunohistochemistry, showing tumor blood vessels cytoplasmic staining for nestin and for CD15, demonstrating angiogenesis as an important mechanism in germinomas.

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生殖细胞瘤：巢蛋白和CD15在肿瘤血管中的表达。

生殖细胞瘤占颅内生殖细胞肿瘤的三分之二，男女比例为8:22。这种肿瘤的一个特征是其充足的血管性，这一点以前没有用Nestin、YAP和CD15等标记物进行过研究，这可以提供有关这种肿瘤生物学的有价值的信息。免疫组织化学分析这些标记物，显示肿瘤血管细胞质中巢蛋白和CD15的染色，表明血管生成是生殖细胞瘤的重要机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology International 医学-病理学

CiteScore

4.50

自引率

4.50%

发文量

102

审稿时长

12 months

期刊介绍： Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.