C-Myc Overexpression in Adolescent and Young Adult Breast Cancer: Distinct From Older Adults With Relevantly Expressed Cholecystokinin B Receptor.

IF 3.4 4区 医学 Q2 PATHOLOGY
Pathology International Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI:10.1111/pin.70047
Tomoyuki Tanino, Yoko Nakanishi, Haruna Nishimaki-Watanabe, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Yukari Hirotani, Sachie Hashimoto, Chie Watanabe, Hiroko Bando, Chikako Shimizu, Shinobu Masuda
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Abstract

Breast cancer in adolescents and young adults has poorer clinical outcomes, but the role of MYC in this group remains unclear. We aimed to elucidate the characteristics of MYC expression in breast cancer among adolescents and young adults. MYC expression in 42 adolescents and young adults and 110 older adults were analyzed using immunohistochemistry, fluorescence in situ hybridization, quantitative polymerase chain reaction, and RNA sequencing. Immunohistochemical c-myc expression was higher in adolescents and young adults group compared to older adults, without MYC gene amplification. In older adults, c-myc expression was associated with more aggressive features. Adolescents and young adults group showed higher c-myc expression even in tumors with less aggressive features, such as estrogen receptor positive, low Ki-67 labeling index, and early clinical stage, than older adults. RNA sequencing revealed higher expression of cholecystokinin B receptor and lower expression of uridine diphosphate glucuronosyltransferase 2 family member B4 in c-myc positive tumors of adolescents and young adults group. The preference of positive cases for both c-myc and cholecystokinin B receptor was significantly higher in adolescents and young adults group. In conclusion, c-myc overexpression makes adolescents and young adults breast cancer more aggressive through multifaceted roles including relevantly expressed cholecystokinin B receptor. Clinical trial registration: This study is not a clinical trial.

C-Myc在青少年和青年乳腺癌中的过表达:与胆囊收缩素B受体相关表达的老年人不同
青少年和青壮年乳腺癌的临床预后较差,但MYC在这一群体中的作用尚不清楚。我们的目的是阐明MYC在青少年和年轻人乳腺癌中的表达特征。采用免疫组织化学、荧光原位杂交、定量聚合酶链反应和RNA测序对42名青少年和年轻人以及110名老年人的MYC表达进行了分析。免疫组化c-myc在青少年和青壮年组的表达高于老年人,没有MYC基因扩增。在老年人中,c-myc表达与更具侵袭性的特征相关。即使在雌激素受体阳性、Ki-67标记指数低、临床分期较早等侵袭性较弱的肿瘤中,青少年和青壮年组的c-myc表达也高于老年人。RNA测序结果显示,在青少年和青壮年c-myc阳性肿瘤中,胆囊收缩素B受体表达较高,尿苷二磷酸葡萄糖醛基转移酶2家族成员B4表达较低。c-myc和胆囊收缩素B受体阳性的偏好在青少年和青壮年组中明显更高。总之,c-myc过表达通过包括相关表达的胆囊收缩素B受体在内的多方面作用使青少年和青壮年乳腺癌更具侵袭性。临床试验注册:本研究不是临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathology International
Pathology International 医学-病理学
CiteScore
4.50
自引率
4.50%
发文量
102
审稿时长
12 months
期刊介绍: Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.
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