Pathology International最新文献_第7页

A case of hepatoid adenocarcinoma of the lung harboring KRAS G12C responded favorably to sotorasib. 一例携带 KRAS G12C 的肺肝样腺癌患者对索托拉西布治疗反应良好。

IF 2.5 4区医学

Pathology International Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI: 10.1111/pin.13464

Hironori Uruga, Atsushi Miyamoto, Takeshi Fujii, Takashi Okuma, Takahiro Mitsumura, Meiyo Tamaoka, Yutaka Takazawa

{"title":"A case of hepatoid adenocarcinoma of the lung harboring KRAS G12C responded favorably to sotorasib.","authors":"Hironori Uruga, Atsushi Miyamoto, Takeshi Fujii, Takashi Okuma, Takahiro Mitsumura, Meiyo Tamaoka, Yutaka Takazawa","doi":"10.1111/pin.13464","DOIUrl":"10.1111/pin.13464","url":null,"abstract":"Hepatoid adenocarcinoma of the lung is a rare variant of adenocarcinoma. We describe a case of hepatoid adenocarcinoma of the lung that harbored KRAS G12C and responded favorably to sotorasib. A man in his 70s was found to have an abnormality on his chest X-ray. He underwent right middle lobectomy, and a pathological examination of the surgical specimen showed conventional invasive adenocarcinoma with highly focal hepatoid adenocarcinoma. He received chemoradiotherapy and concurrent radiation, followed by durvalumab for postoperative recurrence. After three doses of durvalumab, he reported feeling short of breath. A computed tomography scan showed emerging broad consolidation in the right lower lobe. Transbronchial lung biopsy specimens from the consolidation showed hepatoid adenocarcinoma harboring KRAS G12C mutation. Therefore, he was started on sotorasib 960 mg daily. Eight days later, a computed tomography scan showed that the area of consolidation had reduced in size. Progressive disease was detected after 42 days of treatment with sotorasib. The patient died 1 month after cessation of sotorasib and 3 months after postoperative recurrence. We have encountered what we believe to be the first case of hepatoid adenocarcinoma of the lung with KRAS G12C mutation that responded favorably to treatment with sotorasib.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"546-551"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital whole-slide imaging of changes in amyloid after peripheral blood stem cell transplantation in patients with amyloid light-chain amyloidosis. 淀粉样轻链淀粉样变性病患者外周血干细胞移植后淀粉样蛋白变化的数字全切片成像。

IF 2.5 4区医学

Pathology International Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI: 10.1111/pin.13466

Kei Kono, Naoki Sawa, Atsushi Wake, Yukako Shintani-Domoto, Takeshi Fujii, Yutaka Takazawa, Yoshifumi Ubara, Kenichi Ohashi

{"title":"Digital whole-slide imaging of changes in amyloid after peripheral blood stem cell transplantation in patients with amyloid light-chain amyloidosis.","authors":"Kei Kono, Naoki Sawa, Atsushi Wake, Yukako Shintani-Domoto, Takeshi Fujii, Yutaka Takazawa, Yoshifumi Ubara, Kenichi Ohashi","doi":"10.1111/pin.13466","DOIUrl":"10.1111/pin.13466","url":null,"abstract":"Peripheral blood stem cell transplantation (PBSCT) has made amyloid light-chain (AL) amyloidosis treatable. After PBSCT, hematological complete remission (HCR) can be achieved, leading to improved renal prognosis. The purpose of this study was to evaluate whether whole slide imaging of biopsy samples shows a post-treatment reduction in amyloid deposits in patients with AL amyloidosis. Patients were divided into three groups: Group A (n = 8), not eligible for PBSCT and treated with other therapies; Group B (n = 11), treated with PBSCT and achieved HCR; and Group C (n = 5), treated with PBSCT but did not achieve HCR. Clinical findings and amyloid deposition in glomeruli, interstitium, and blood vessels were compared before and after treatment using digital whole-slide imaging. Proteinuria and hypoalbuminemia improved more in Group B than in the other groups, and in Group B, amyloid deposition improved more in the glomeruli than in the interstitium and blood vessels. The long-term renal and survival prognosis was better in Group B than in the other groups. PBSCT can be expected to improve long-term clinical and renal histological prognosis in patients with AL amyloidosis who achieve HCR. Amyloid disappearance from renal tissue may take a long time even after clinical HCR.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"508-519"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autopsy case of linear nevus sebaceous syndrome with KRAS (G12D) mutation. KRAS（G12D）突变的线性皮脂腺痣综合征尸检病例。

IF 2.5 4区医学

Pathology International Pub Date : 2024-09-01 Epub Date: 2024-07-12 DOI: 10.1111/pin.13463

Akira Ohishi, Yasunori Enomoto, Hideto Iwafuchi, Shiori Meguro, Isao Kosugi, Satoshi Baba, Toshihide Iwashita, Yuki Segawa, Daizo Ueno, Shigeo Iijima

{"title":"Autopsy case of linear nevus sebaceous syndrome with KRAS (G12D) mutation.","authors":"Akira Ohishi, Yasunori Enomoto, Hideto Iwafuchi, Shiori Meguro, Isao Kosugi, Satoshi Baba, Toshihide Iwashita, Yuki Segawa, Daizo Ueno, Shigeo Iijima","doi":"10.1111/pin.13463","DOIUrl":"10.1111/pin.13463","url":null,"abstract":"Linear nevus sebaceous syndrome (LNSS) is a neurocutaneous syndrome associated with systemic complications that involve multiple organs, including the skin, central nervous system, eyes, and skeleton. LNSS is considered to be caused by mosaic RAS gene mutation. In this report, we present an autopsy case of LNSS in a Japanese boy. The affected neonate had hydrops fetalis and was born at 28 weeks and 4 days of gestation, weighing 2104 g. He had bilateral inverted eyelids, verrucous linear nevus separated along Blaschko's line, myocardial hypertrophy, and pharyngeal constriction, and underwent intensive treatment in NICU for arrhythmia, hydrocephalus, and respiratory distress. The hydrocephalus progressed gradually and he died at the age of 181 days, 12 days after a sudden cardiac arrest and recovery. KRAS G12D mutation was found in a skin biopsy specimen but not in blood cells, suggesting a postzygotic mosaicism. Autopsy revealed novel pathological findings related to LNSS, including intracranial lipomatous hamartoma and mesenteric lymphangioma, in addition to previously reported findings such as multicystic dysplastic kidney. There was the limited expression of mutated KRAS protein in kidneys.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"538-545"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological evaluation of the pathogenesis of diabetes mellitus and diabetic peripheral neuropathy. 对糖尿病和糖尿病周围神经病变发病机制的病理学评估。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-06-18 DOI: 10.1111/pin.13458

Hiroki Mizukami

{"title":"Pathological evaluation of the pathogenesis of diabetes mellitus and diabetic peripheral neuropathy.","authors":"Hiroki Mizukami","doi":"10.1111/pin.13458","DOIUrl":"10.1111/pin.13458","url":null,"abstract":"Currently, there are more than 10 million patients with diabetes mellitus in Japan. Therefore, the need to explore the pathogenesis of diabetes and the complications leading to its cure is becoming increasingly urgent. Pathological examination of pancreatic tissues from patients with type 2 diabetes reveals a decrease in the volume of beta cells because of a combination of various stresses. In human type 2 diabetes, islet amyloid deposition is a unique pathological change characterized by proinflammatory macrophage (M1) infiltration into the islets. The pathological changes in the pancreas with islet amyloid were different according to clinical factors, which suggests that type 2 diabetes can be further subclassified based on islet pathology. On the other hand, diabetic peripheral neuropathy is the most frequent diabetic complication. In early diabetic peripheral neuropathy, M1 infiltration in the sciatic nerve evokes oxidative stress or attenuates retrograde axonal transport, as clearly demonstrated by in vitro live imaging. Furthermore, islet parasympathetic nerve density and beta cell volume were inversely correlated in type 2 diabetic Goto-Kakizaki rats, suggesting that diabetic peripheral neuropathy itself may contribute to the decrease in beta cell volume. These findings suggest that the pathogenesis of diabetes mellitus and diabetic peripheral neuropathy may be interrelated.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"438-453"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell hidradenoma of the breast with MAML2 gene rearrangement. 伴有 MAML2 基因重排的乳腺透明细胞色素痣。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI: 10.1111/pin.13455

Li Luo, Yanping Hu

{"title":"Clear cell hidradenoma of the breast with MAML2 gene rearrangement.","authors":"Li Luo, Yanping Hu","doi":"10.1111/pin.13455","DOIUrl":"10.1111/pin.13455","url":null,"abstract":"Clear cell hidradenoma is a rare benign tumor of the breast, its origin and pathogenesis are controversial. We have experienced a case of breast clear cell hidradenoma with mastermind like transcriptional coactivator 2 (MAML2) gene rearrangement. The patient found a painless mass with a hard texture in the left breast areola without nipple discharge. Microscopically, the tumor was cystic and solid, locally arranged in a glandular structure, covered by single cuboidal cells; it was composed of clear cells, epidermoid cells, and basaloid cells; there were no necrosis or mitotic figures. Immunohistochemical staining showed that the tumor cells positively expressed low-molecular cytokeratin 7, low-molecular cytokeratins (Cam5.2), high-molecular cytokeratin 5/6, cytokeratin 14, CD117, and p63; and did not express calponin, and smooth muscle myosin heavy chain. The cuboidal cells were positive for SOX10 but negative for p63. Additionally, periodic acid-Schiff reaction showed purple-red granules in the tumor cytoplasm, but Alcian blue staining showed no blue mucus in the cytoplasm. The split signals of MAML2 gene were detected by fluorescence in situ hybridization. Subtle histological and immunophenotypical differences may help to distinguish breast clear cell hidradenoma from common breast tumors. Furthermore, the MAML2 gene rearrangement may be a molecular genetic characteristic of breast clear cell hidradenoma.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"482-488"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cysts of the ligamentum flavum are often linked to ischemic conditions: A morphological study. 黄韧带囊肿通常与缺血性疾病有关：形态学研究。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-07-12 DOI: 10.1111/pin.13465

Ayano Matsunaga, Mariko Saito, Kaya Ijiri, Motohiro Tsuchiya, Akimasa Yasuda, Kazuya Kitamura, Sho Ogata, Kazuhiro Chiba, Susumu Matsukuma

{"title":"Cysts of the ligamentum flavum are often linked to ischemic conditions: A morphological study.","authors":"Ayano Matsunaga, Mariko Saito, Kaya Ijiri, Motohiro Tsuchiya, Akimasa Yasuda, Kazuya Kitamura, Sho Ogata, Kazuhiro Chiba, Susumu Matsukuma","doi":"10.1111/pin.13465","DOIUrl":"10.1111/pin.13465","url":null,"abstract":"\"Cysts of the ligamentum flavum (cysts-LF)\" is the term for non-neoplastic cystic lesion involving LF. The aim of the present study was to elucidate the histopathological characteristics and pathogenesis of \"cysts-LF\". Herein, we defined cysts-LF as spinal cysts containing degenerative LF components. From archival cases, we investigated 18 symptomatic cysts-LF surgically removed from 18 patients (13 males and five females; median age 68.5 years [range, 42-86 years]). The elastic fibers of LF components in the wall were separated and/or torn, and cyst walls were accompanied by chondroid metaplasia (17 cases), myxoid changes (13 cases), ossification (11 cases), amyloid deposits (14 cases), hemosiderosis (six cases), granular/smudgy calcification (four cases), synovial cell linings (three cases), and severe inflammatory infiltrates (one case). These histologic features of our cysts-LF were shared by previously reported \"cysts-LF.\" Fourteen cysts-LF demonstrated vascular stenosis/occlusion, and eight showed thick hyalinized vessels, suggesting local circulatory insufficiency. Eight cases (44%) exhibited lipomembranous fat necrosis, accompanied by hyalinized vascular changes (p = 0.003). Ischemic conditions were observed in nearly half of the present cysts-LF, and may be one of the main contributing factors for the formation of cysts-LF, via degeneration and cystic changes in the LF.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"475-481"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sporadic gastric foveolar-type adenoma with morular metaplasia. 伴有形态变异的零星胃窝状腺瘤。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-07-17 DOI: 10.1111/pin.13462

Tetsuhiro Yamakado, Zen-Ichi Tanei, Yuka Ishikawa, Taichi Kimura, Yusuke Ishida, Shinya Tanaka

引用次数: 0

High expression of eukaryotic elongation factor 1-alpha-2 in lung adenocarcinoma is associated with poor prognosis. 肺腺癌中真核延伸因子 1-α-2 的高表达与预后不良有关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-06-14 DOI: 10.1111/pin.13457

Mariko Yamato, Tomoko Dai, Yoshihiko Murata, Tomoki Nakagawa, Shinji Kikuchi, Daisuke Matsubara, Masayuki Noguchi

{"title":"High expression of eukaryotic elongation factor 1-alpha-2 in lung adenocarcinoma is associated with poor prognosis.","authors":"Mariko Yamato, Tomoko Dai, Yoshihiko Murata, Tomoki Nakagawa, Shinji Kikuchi, Daisuke Matsubara, Masayuki Noguchi","doi":"10.1111/pin.13457","DOIUrl":"10.1111/pin.13457","url":null,"abstract":"Eukaryotic elongation factor 1 alpha 2 (eEF1A2) encodes an isoform of the alpha subunit of the elongation factor 1 complex and is responsible for the enzymatic delivery of aminoacyl tRNA to the ribosome. Our proteomic analysis has identified eEF1A2 as one of the proteins expressed during malignant progression from adenocarcinoma in situ (AIS) to early invasive lung adenocarcinoma. The expression level of eEF1A2 in 175 lung adenocarcinomas was examined by immunohistochemical staining in relation to patient prognosis and clinicopathological factors. Quantitative PCR analysis and fluorescence in situ hybridization (FISH) were performed to evaluate the amplification of the eEF1A2 gene. Relatively high expression of eEF1A2 was observed in invasive adenocarcinoma (39/144 cases) relative to minimally invasive adenocarcinoma (1/10 cases) or AIS (0/21 cases). Among invasive adenocarcinomas, solid-type adenocarcinoma (15/32 cases, 47%) showed higher expression than other histological subtypes (23/92, 25%). Patients with eEF1A2-positive tumors had a significantly poorer prognosis than those with eEF1A2-negative tumors. Of the five tumors that were eEF1A2-positive, two cases showed amplified genomic eEF1A2 DNA, which was confirmed by both qPCR and FISH. These findings indicate that eEF1A2 overexpression occurs in the course of malignant transformation of lung adenocarcinomas and is partly due to eEF1A2 gene amplification.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"454-463"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomal miR-196a-5p contributes to esophageal squamous cell carcinoma malignant progression by inhibiting ITM2B. 外泌体 miR-196a-5p 通过抑制 ITM2B 促进食管鳞状细胞癌的恶性发展。

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI: 10.1111/pin.13459

Min Huang, Shuang Li, Hai Zeng, Yan Zhu, Fan Zhang, Jun Cai

{"title":"Exosomal miR-196a-5p contributes to esophageal squamous cell carcinoma malignant progression by inhibiting ITM2B.","authors":"Min Huang, Shuang Li, Hai Zeng, Yan Zhu, Fan Zhang, Jun Cai","doi":"10.1111/pin.13459","DOIUrl":"10.1111/pin.13459","url":null,"abstract":"Exosomes from cancer cells function as carriers to spread or transport specific microRNAs (miRNAs) to distant sites to exert their effects, but the mechanism of exosomal miRNA action in esophageal squamous cell carcinoma (ESCC) has not been fully explained. Therefore, in this study, we were interested in the impact of exosomal miR-196a-5p in ESCC progression. We found that miR-196a-5p was expressed enriched in clinical tissues, ESCC cells, and exosomes. Functionally, depletion of miR-196a-5p impeded ESCC cell growth, migration, and invasion, whereas overexpression of miR-196a-5p produced the opposite results. Moreover, enhancement of exosomal miR-196a-5p in recipient ESCC cells triggered more intense proliferation and migration. Mechanistically, we identified integral membrane protein 2B (ITM2B) as a direct target of miR-196a-5p. Silencing of ITM2B partially counteracted the inhibitory effect of miR-196a-5p inhibitors on the malignant phenotype of ESCC. Furthermore, in vivo, lower miR-196a-5p levels triggered by the introduction of antagomiR-196a-5p resulted in the generation of smaller volume and weight xenograft tumors. Thus, our results demonstrated novel mechanisms of exosomal and intracellular miR-196a-5p-mediated ESCC growth and migration and identify the interaction of miR-196a-5p with ITM2B. These works might provide new targets and basis for the development of clinical treatment options for ESCC.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"464-474"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric dysplastic lesions in Helicobacter pylori-naïve stomach: Foveolar-type adenoma and intestinal-type dysplasia. 幽门螺旋杆菌未感染胃的胃部发育不良病变：蜂窝型腺瘤和肠型发育不良

IF 2.5 4区医学

Pathology International Pub Date : 2024-08-01 Epub Date: 2024-06-05 DOI: 10.1111/pin.13456

Kotaro Shibagaki, Ryoji Kushima, Tsuyoshi Mishiro, Asuka Araki, Daisuke Niino, Norihisa Ishimura, Shunji Ishihara

{"title":"Gastric dysplastic lesions in Helicobacter pylori-naïve stomach: Foveolar-type adenoma and intestinal-type dysplasia.","authors":"Kotaro Shibagaki, Ryoji Kushima, Tsuyoshi Mishiro, Asuka Araki, Daisuke Niino, Norihisa Ishimura, Shunji Ishihara","doi":"10.1111/pin.13456","DOIUrl":"10.1111/pin.13456","url":null,"abstract":"Reports of Helicobacter pylori (Hp)-naïve gastric neoplasm (HpNGN) cases have been rapidly increasing due to the recent increase in the Hp-naïve population in Japan. Most HpNGNs exhibit the gastric immunophenotype and a low malignant potential regardless of histological type. Especially, foveolar-type gastric adenoma (FGA) and intestinal-type gastric dysplasia (IGD) rarely progress to invasive carcinoma. FGA is a foveolar epithelial neoplasm that occurs in the fundic gland (oxyntic gland) mucosa and is classified as the flat type or raspberry type (FGA-RA). The flat type is a large, whitish flatly elevated lesion while FGA-RA is a small reddish polyp. Genomically, the flat type is characterized by APC and KRAS gene mutations and FGA-RA by a common single nucleotide variant in the KLF4 gene. This KLF4 single-nucleotide variant reportedly induces gastric foveolar epithelial tumorigenesis and activates both cell proliferation and apoptosis, leading to its slow-growing nature. IGD consists of an intestinalized epithelial dysplasia that develops in the pyloric gland mucosa, characterized as a superficial depressed lesion surrounded by raised mucosa showing a gastritis-like appearance. Immunohistochemically, it exhibits an intestinal or gastrointestinal phenotype and, frequently, p53 overexpression. Thus, IGD shows unique characteristics in HpNGNs and a potential multistep tumorigenic process.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"423-437"},"PeriodicalIF":2.5,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0