Pathology International最新文献_第7页

Cancer-Associated Fibroblasts in Invasion Front Can be a Prognostic Predictor for Oral Squamous Cell Carcinoma. 侵袭前癌相关成纤维细胞可作为口腔鳞状细胞癌的预后预测因子。

IF 1.9 4区医学

Pathology International Pub Date : 2026-06-01 DOI: 10.1111/pin.70135

Yuuki Ishii, Joaquim Carreras, Yukie Yara Kikuchi, Yusuke Kondo, Masashi Sasaki, Takayuki Aoki, Yoshihide Ota, Naoya Nakamura

{"title":"Cancer-Associated Fibroblasts in Invasion Front Can be a Prognostic Predictor for Oral Squamous Cell Carcinoma.","authors":"Yuuki Ishii, Joaquim Carreras, Yukie Yara Kikuchi, Yusuke Kondo, Masashi Sasaki, Takayuki Aoki, Yoshihide Ota, Naoya Nakamura","doi":"10.1111/pin.70135","DOIUrl":"10.1111/pin.70135","url":null,"abstract":"Tumor immune microenvironment (TME) is an important pathogenic component in cancer, and a therapeutic target. To examine the role of the TME, especially cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (SCC), a retrospective cohort study of 684 patients with surgically resected tissues was performed. Clinicopathological variables and immuno-oncology markers were analyzed by immunohistochemistry (IHC) focusing on the invasion front of SCC, including α-smooth muscle actin-positive CAFs, CD163-positive M2-like tumor-associated macrophages (TAMs), CD68-positive pan-macrophages, tumor protein p53, and T-cell intracellular antigen 1 (TIA-1)-positive cytotoxic T-lymphocytes (CTLs) by IHC in invasion front of SCC were analyzed. Each of high infiltration of CAFs, high M2-like TAMs, high or negative p53 expression, and low TIA-1-positive CTLs was associated with poor survival of the patients. In a multivariate analysis, age ≥ 75 years, performance status ≥ 1, extranodal extension, vessel invasion, moderate and poorly differentiated histological grade, and high CAF infiltration were associated with poor 5-year overall survival (all HR > 1, p-values < 0.05). Among the immuno-oncology markers, IHC analysis of the CAFs was one of the most useful markers for predicting survival of patients with oral SCC. High infiltration of CAFs was associated with poor overall survival.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 6","pages":"e70135"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Upregulated Mucin 21 in Detached Lung Cancer Cells. 黏液蛋白21在离体肺癌细胞中的作用

IF 1.9 4区医学

Pathology International Pub Date : 2026-06-01 DOI: 10.1111/pin.70141

Ryotaro Sakio, Tamaki Miura, Atsushi Kihara, Yusuke Amano, Taichiro Yoshimoto, Nobuhiko Ohno, Kaori Denda-Nagai, Tatsuro Irimura, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Daisuke Komura, Shumpei Ishikawa, Tetsuo Ushiku, Naohiro Sata, Joji Kitayama, Hironori Yamaguchi, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki

{"title":"Role of Upregulated Mucin 21 in Detached Lung Cancer Cells.","authors":"Ryotaro Sakio, Tamaki Miura, Atsushi Kihara, Yusuke Amano, Taichiro Yoshimoto, Nobuhiko Ohno, Kaori Denda-Nagai, Tatsuro Irimura, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Daisuke Komura, Shumpei Ishikawa, Tetsuo Ushiku, Naohiro Sata, Joji Kitayama, Hironori Yamaguchi, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki","doi":"10.1111/pin.70141","DOIUrl":"https://doi.org/10.1111/pin.70141","url":null,"abstract":"The molecular mechanisms underlying metastasis still remain unclear. We previously established a suspension culture using low-attachment culture dishes and demonstrated that cell lines adapted through 2 months suspension culture (termed FL sublines) exhibited higher metastatic potential than their parental counterparts. In this study, we identified the molecules involved in acquiring these phenotypes under low-adhesion conditions. We showed that detached tumor cells in suspension culture formed spheroids that recapitulated tumor cells in the spread-through-air space (STAS), and demonstrated that the anti-adhesion molecule mucin 21 was upregulated in detached lung cancer cells independent of driver mutations. Analyses of both cell lines and primary tumors revealed that mucin 21 is overexpressed in terminal respiratory unit-type lung adenocarcinomas. Mucin 21-knockout cells showed reduced viability and proliferation under adherent and low-attachment conditions, accompanied by enhanced anoikis. Transmission electron microscopy revealed that the intercellular spaces observed in FL sublines during suspension culture were reduced in mucin 21-knockout cells, suggesting impaired acquisition of low adhesive properties. Thus, mucin 21 appears crucial for the survival of terminal respiratory unit-type lung adenocarcinoma cells under both adherent and low-adhesion conditions.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 6","pages":"e70141"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Visualizing Cytosine Methylation and Allele-Specific Epigenetic States in Tissue Context. 组织背景下胞嘧啶甲基化和等位基因特异性表观遗传状态可视化研究进展。

IF 1.9 4区医学

Pathology International Pub Date : 2026-06-01 DOI: 10.1111/pin.70133

Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa

{"title":"Advances in Visualizing Cytosine Methylation and Allele-Specific Epigenetic States in Tissue Context.","authors":"Sohei Kitazawa, Ryuma Haraguchi, Riko Kitazawa","doi":"10.1111/pin.70133","DOIUrl":"10.1111/pin.70133","url":null,"abstract":"Epigenetic regulation represents a heritable, sequence-independent layer of transcriptional control that critically shapes tissue morphology throughout development, homeostasis, and disease. Although immunohistochemical detection of histone modifications is now well established in diagnostic pathology, direct visualization of DNA methylation-the central mechanism underlying transcriptional silencing, genomic imprinting, and cellular identity-remains far more challenging. To address this limitation, a range of histochemical and cytochemical approaches has been developed to detect methylated cytosines within morphologically preserved tissues. Early strategies based on differential restriction enzyme sensitivity enabled global in situ assessment of CpG methylation, while bisulfite-dependent padlock-probe hybridization introduced sequence specificity through conversion-based discrimination of methylated and unmethylated cytosines. More recently, the ICON method has provided bisulfite-free, base-resolved detection of methylated CpG sites with single-cell precision, allowing direct visualization of allele-specific DNA methylation (ASM) within intact nuclei. These techniques reveal dynamic shifts between monoallelic and biallelic methylation during differentiation, exemplified by transitions at the Rankl promoter in osteogenic lineages. This review summarizes methodological advances in tissue-based DNA methylation detection and highlights how spatially resolved, sequence-specific approaches deepen our understanding of epigenetic regulation within histological architecture.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 6","pages":"e70133"},"PeriodicalIF":1.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD30+ High Grade Neoplasm With Expression of β-HCG and T-Cell Markers: Hybrid Germ Cell Tumor and T-Cell Lymphoma? CD30+高级别肿瘤伴β-HCG和t细胞标志物表达：杂交生殖细胞瘤和t细胞淋巴瘤？

IF 3.4 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70120

Wei J Wang, L Jeffrey Medeiros, Guilin Tang, Sofia Garces, Charles Guo, Qiong Gan, Shaoying Li, Pei Lin, Wei Wang, Jie Xu

引用次数: 0

Carcinogenicity of Dimethylarsinic Acid: Evidence From Experimental Models and Mechanistic Insights. 二甲基胂酸的致癌性：来自实验模型和机理的证据。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70097

Hideki Wanibuchi

{"title":"Carcinogenicity of Dimethylarsinic Acid: Evidence From Experimental Models and Mechanistic Insights.","authors":"Hideki Wanibuchi","doi":"10.1111/pin.70097","DOIUrl":"10.1111/pin.70097","url":null,"abstract":"Arsenic is a well-established human carcinogen and a major global environmental health concern. However, the mechanisms underlying arsenic-induced carcinogenesis remain incompletely understood. This review focuses on dimethylarsinic acid (DMAV), a principal urinary metabolite of inorganic arsenic in humans. Using various animal models, we demonstrated that DMAV promotes carcinogenesis in multiple organs, including the urinary bladder, liver, kidney, and thyroid gland. Two-year bioassays confirmed that DMAV functions as a complete carcinogen in the rat bladder. Furthermore, transplacental exposure to DMAV induced lung and liver tumors in male offspring, highlighting increased fetal susceptibility. Mechanistic investigations revealed a central role for oxidative DNA damage and gene dysregulation in DMAV-induced tumorigenesis. We also identified epigenetic alterations, including aberrant DNA methylation and histone modifications, as key contributors to tumor development, with distinct patterns observed between fetal and adult exposures. Collectively, these findings provide robust experimental evidence for the carcinogenic potential of DMAV and clarify its underlying mechanisms. Our work contributed significantly to the classification of DMAV as \"probably carcinogenic to humans\" (Group 2 A) by the International Agency for Research on Cancer, underscoring its relevance to human health risk assessment.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 5","pages":"e70097"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Interstitial Glycogenosis as a Developmental Marker of BHD-Associated Lung Cysts: Diagnostic and Pathogenetic Implications. 肺间质糖原症作为bhd相关肺囊肿的发育标志：诊断和病理意义。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70127

Daiji Nemoto, Ryosuke Kumagai, Mitsuko Furuya, Saki Iwasaki, Ryoko Yasumatsu, Wataru Tokuyama, Mayumi Yakeishi, Takahiro Tsuji, Yoshihiro Ishikawa, Yukio Nakatani

引用次数: 0

A Case of Incidentally Followed Thoracic SMARCA4-Deficient Undifferentiated Tumor: Insights Into the Tumor Origin. 偶然继发胸腔smarca4缺陷未分化肿瘤1例：对肿瘤起源的认识。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70130

Hironori Uruga, Hiroshi Nakahama, Hiroshi Hirakawa, Katsunori Oikado, Takayuki Tsujimoto, Takahiro Mitsumura, Meiyo Tamaoka, Sakashi Fujimori, Takeshi Fujii, Yutaka Takazawa

{"title":"A Case of Incidentally Followed Thoracic SMARCA4-Deficient Undifferentiated Tumor: Insights Into the Tumor Origin.","authors":"Hironori Uruga, Hiroshi Nakahama, Hiroshi Hirakawa, Katsunori Oikado, Takayuki Tsujimoto, Takahiro Mitsumura, Meiyo Tamaoka, Sakashi Fujimori, Takeshi Fujii, Yutaka Takazawa","doi":"10.1111/pin.70130","DOIUrl":"10.1111/pin.70130","url":null,"abstract":"Thoracic SMARCA4-deficient undifferentiated tumor (UT) is a malignant neoplasm characterized by undifferentiated and/or rhabdoid morphology. This report describes a case of SMARCA4-deficient UT that was incidentally followed by computed tomography. The patient was a man in his 70 s who was undergoing regular chest computed tomography for postoperative surveillance of renal cell carcinoma. Twenty months before diagnosis of SMARCA4-deficient UT, a pulmonary cyst was noted adjacent to the chest wall and increased in size over time. A right upper lobectomy with partial pleurectomy was performed for diagnostic and therapeutic purposes. Macroscopically, we identified a 30-mm mass located predominantly in the chest wall. Histological examination revealed a proliferation of atypical polygonal cells or partly spindle-shaped with prominent nucleoli and irregular nuclear membranes in a nested pattern within the chest wall and lung tissue and partially within striated muscle tissue. Immunohistochemically, the tumor cells showed loss of expression of BRG1/SMARCA4 and BRM/SMARCA2. The extrapulmonary component was positive for CD34 and had a Ki-67 index that was higher than that in the intrapulmonary component. The radiological, pathological, and molecular findings led to a diagnosis of SMARCA4-deficient UT of intrapulmonary origin.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 5","pages":"e70130"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incomplete Intestinal Metaplasia in Pyloric Gland Mucosa of Helicobacter pylori-Naïve Stomachs: A Prospective Multicenter Histopathologic Study. 幽门螺杆菌pylori-Naïve胃幽门腺黏膜不完全肠化生：一项前瞻性多中心组织病理学研究。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70126

Shinsuke Suemitsu, Kotaro Shibagaki, Asuka Araki, Yoichi Miyaoka, Koichiro Furuta, Tsuyoshi Mishiro, Masahito Aimi, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba, Norihisa Ishimura, Mamiko Nagase, Shigeru Kawabata, Daisuke Niino, Ryoji Kushima, Shunji Ishihara

{"title":"Incomplete Intestinal Metaplasia in Pyloric Gland Mucosa of Helicobacter pylori-Naïve Stomachs: A Prospective Multicenter Histopathologic Study.","authors":"Shinsuke Suemitsu, Kotaro Shibagaki, Asuka Araki, Yoichi Miyaoka, Koichiro Furuta, Tsuyoshi Mishiro, Masahito Aimi, Yusuke Takahashi, Satoshi Kotani, Nobuhiko Fukuba, Norihisa Ishimura, Mamiko Nagase, Shigeru Kawabata, Daisuke Niino, Ryoji Kushima, Shunji Ishihara","doi":"10.1111/pin.70126","DOIUrl":"10.1111/pin.70126","url":null,"abstract":"Helicobacter pylori (Hp)-naïve gastric mucosa has been characterized histologically by the absence of Hp organisms, atrophy, and intestinal metaplasia (IM). We conducted a prospective multicenter study to clarify the prevalence and clinicopathologic features of IM in the Hp-naïve stomach. Hp-naïve individuals with regional gastric mucosal abnormalities detected by endoscopy were enrolled. Biopsies were obtained from target lesions and adjacent mucosa. IM frequency and Updated Sydney System (USS) scores were assessed by glandular background (pyloric vs. fundic) in both target and adjacent samples. Among 52 target and 56 adjacent samples, pyloric and fundic gland mucosa accounted for 28 and 24 target samples and 21 and 35 adjacent samples, respectively. IM was detected exclusively in pyloric gland mucosa of target lesions (46.4% vs. 0%, p < 0.05) and was absent in adjacent mucosa. Atrophy scores were low overall but significantly higher in pyloric than fundic gland mucosa in both target lesions (median [IQR], 1 [1-2] vs. 0 [0-1], p < 0.05) and adjacent mucosa (1 [1-2] vs. 1 [0-1], p < 0.05). All IM lesions were classified as incomplete type, showing predominant small intestinal-type differentiation with residual gastric foveolar markers. Histological evaluation of Hp-naïve gastric mucosa should be region-specific, with attention to glandular architecture.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 5","pages":"e70126"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13181229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological Features of Lung Squamous Cell Carcinoma According to Radiological Early-Phase Progression Patterns. 肺鳞状细胞癌早期放射学进展模式的组织学特征。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70124

Masahiro Adachi, Jumpei Kashima, Haruto Sugawara, Satsuki Kishikawa, Hirokazu Watanabe, Masaya Yotsukura, Tomohiro Haruki, Yukihiro Yoshida, Hiroshi Igaki, Shun-Ichi Watanabe, Masahiko Kusumoto, Yasushi Yatabe

{"title":"Histological Features of Lung Squamous Cell Carcinoma According to Radiological Early-Phase Progression Patterns.","authors":"Masahiro Adachi, Jumpei Kashima, Haruto Sugawara, Satsuki Kishikawa, Hirokazu Watanabe, Masaya Yotsukura, Tomohiro Haruki, Yukihiro Yoshida, Hiroshi Igaki, Shun-Ichi Watanabe, Masahiko Kusumoto, Yasushi Yatabe","doi":"10.1111/pin.70124","DOIUrl":"10.1111/pin.70124","url":null,"abstract":"We have previously reported radiological patterns of precursor lesions of lung squamous cell carcinoma (SqCCs) using computed tomography. SqCCs were found to develop from five unique precursor patterns. We histologically analyzed 61 cases from the previous cohort to evaluate whether these precursor patterns reflect possible developmental pathways. Of the precursor patterns, the endobronchial group demonstrated involvement of large bronchi in the hilar region. In the subsolid nodule pattern group, which exhibited ground-glass opacities radiologically, the tumors showed intra-alveolar wall infiltration, nuclear inclusion/vacuoles, low mitotic count, and absent atypical mitosis. In two of the seven cases in this group, lepidic growth, corresponding to ground-glass opacity, occurred at the tumor periphery. In the cyst wall thickening group, the tumors were located subpleurally, characterized by papillary growth structures. In the multiple-nodule group, all tumors displayed elastofibrous collapse and intra-alveolar wall infiltration. Overall and recurrence-free survival varied across the progression patterns. The radiological progression patterns were reflected in the histological features, highlighting the unique characteristics of subsolid and multiple nodule groups corresponding to peripheral-type SqCC. This study represented a new approach to the assessment of tumor evolutional pathways with histological features in combination with temporal radiographic changes.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 5","pages":"e70124"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardized Instance-Level Quantification of CD34-Positive Vessels in Lymph Node Whole-Slide Images Using U-Net. 使用U-Net对淋巴结全片图像中cd34阳性血管的标准化实例级量化。

IF 1.9 4区医学

Pathology International Pub Date : 2026-05-01 DOI: 10.1111/pin.70125

Satomi Omotani, Natsumi Yonemoto, Akifumi Muramoto, Motohiro Kobayashi

{"title":"Standardized Instance-Level Quantification of CD34-Positive Vessels in Lymph Node Whole-Slide Images Using U-Net.","authors":"Satomi Omotani, Natsumi Yonemoto, Akifumi Muramoto, Motohiro Kobayashi","doi":"10.1111/pin.70125","DOIUrl":"10.1111/pin.70125","url":null,"abstract":"Deep learning enhances quantitative analysis of blood vessels in whole-slide images (WSIs), leading to precise and reliable counting. However, counting vessels in lymph nodes-which contain distinctive high endothelial venules (HEVs)-has not been systematically evaluated. Artificial intelligence (AI) approaches to vessel-counting fall into two categories: semantic segmentation, which provides a continuous mask, and instance segmentation, which treats each vessel as a separate object; prior work has emphasized the former. To address this gap, we adopted an instance-level approach to detect and count individual vessels. We developed a convolutional neural network (CNN) to quantify CD34-positive vessels in lymph-node WSIs, using U-Net, a widely used biomedical segmentation architecture. The model was trained over 4.0 million (4.0 M) iterations, followed by a fixed post-processing procedure to extract vessel instances. At 3.0 M, the model most faithfully captured CD34-positive vascular morphology. In the validation set, this checkpoint showed the highest morphological similarity. Furthermore, detection performance was robust with minimal variation across lymph nodes and training checkpoints. Using a simple fixed procedure, our method achieves accurate vessel detection and counting in lymph-node WSIs. This model provides a practical basis for standardized quantification and for studying lymph-node vascular morphology across normal, inflammatory, and lymphomatous states.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":"76 5","pages":"e70125"},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13161731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0