Pathology International最新文献_第7页

Autopsy report of a sudden infant death that was strongly suspicious of Kawasaki disease. 婴儿猝死的尸检报告，强烈怀疑是川崎病所致。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI: 10.1111/pin.13437

Yuki Yokouchi, Nanae Asakawa, Hirotaro Iwase, Takeshi Nasu, Kei Takahashi

{"title":"Autopsy report of a sudden infant death that was strongly suspicious of Kawasaki disease.","authors":"Yuki Yokouchi, Nanae Asakawa, Hirotaro Iwase, Takeshi Nasu, Kei Takahashi","doi":"10.1111/pin.13437","DOIUrl":"10.1111/pin.13437","url":null,"abstract":"We conducted an autopsy on a 3-month-old boy in whom Kawasaki disease (KD) was strongly suspected based on the autopsy findings. The infant had a fever and was brought to a nearby clinic, where he was prescribed antipyretics and kept under observation. However, 15 days after onset of the fever, he suddenly died in bed. He exhibited no obvious redness of the lips, tongue, or conjunctiva. Membranous desquamation was present on his distal fingers. Vasculitis was observed in the coronary arteries, renal artery, splenic artery, and pulmonary vein. In addition, coronary artery aneurysms were present in the right coronary artery and left anterior descending artery. Thrombotic occlusion was observed in one aneurysm in the right coronary artery, resulting in acute myocardial infarction. The coronary artery wall showed infiltration of numerous macrophages and neutrophils. This case was classified as incomplete KD because the coronary artery aneurysm could not be demonstrated before death and was only recognized at autopsy. Pathologists and forensic scientists need to be aware that there are cases in which KD goes undiagnosed and untreated, leading to coronary artery aneurysm formation and sudden death.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"408-414"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors. 慢性肝损伤和肝肿瘤中肝细胞的异常分化和增殖。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-06-05 DOI: 10.1111/pin.13441

Yuji Nishikawa

{"title":"Aberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors.","authors":"Yuji Nishikawa","doi":"10.1111/pin.13441","DOIUrl":"10.1111/pin.13441","url":null,"abstract":"Chronic liver injury induces liver cirrhosis and facilitates hepatocarcinogenesis. However, the effects of this condition on hepatocyte proliferation and differentiation are unclear. We showed that rodent hepatocytes display a ductular phenotype when they are cultured within a collagenous matrix. This process involves transdifferentiation without the emergence of hepatoblastic features and is at least partially reversible. During the ductular reaction in chronic liver diseases with progressive fibrosis, some hepatocytes, especially those adjacent to ectopic ductules, demonstrate ductular transdifferentiation, but the majority of increased ductules originate from the existing bile ductular system that undergoes extensive remodeling. In chronic injury, hepatocyte proliferation is weak but sustained, and most regenerative nodules in liver cirrhosis are composed of clonally proliferating hepatocytes, suggesting that a small fraction of hepatocytes maintain their proliferative capacity in chronic injury. In mouse hepatocarcinogenesis models, hepatocytes activate the expression of various fetal/neonatal genes, indicating that these cells undergo dedifferentiation. Hepatocyte-specific somatic integration of various oncogenes in mice demonstrated that hepatocytes may be the cells of origin for a broad spectrum of liver tumors through transdifferentiation and dedifferentiation. In conclusion, the phenotypic plasticity and heterogeneity of mature hepatocytes are important for understanding the pathogenesis of chronic liver diseases and liver tumors.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"361-378"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141262518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial comment to "Autopsy report of a sudden infant death that was strongly suspicious of Kawasaki disease". 对 "强烈怀疑为川崎病的婴儿猝死验尸报告 "的编辑评论。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-23 DOI: 10.1111/pin.13440

Hirotake Masuda

引用次数: 0

A modifiable valve-sparing pediatric cardiac dissection technique promotes specimen longevity and optimizes advanced image analysis postpathological examination. 可修改的小儿心脏瓣膜剥离技术可延长标本寿命，优化病理检查后的高级图像分析。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1111/pin.13435

Takato Yamasaki, Shuhei Toba, Stephen P Sanders, Chrystalle Katte Carreon

引用次数: 0

Resurgence of morphology: Discarded small cell lung carcinoma subtypes reflect current molecular classification. 形态学的复苏：被废弃的小细胞肺癌亚型反映了当前的分子分类。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1111/pin.13460

Hironori Ninomiya

引用次数: 0

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer. 毛细血管的特殊形状与浸润性乳腺癌患者的不良预后有关。

IF 2.5 4区医学

Pathology International Pub Date : 2024-07-01 Epub Date: 2024-05-31 DOI: 10.1111/pin.13442

Hnin-Wint-Wint Swe, Masayoshi Fujisawa, Toshiaki Ohara, Yu Komatsubara, Teizo Yoshimura, Tadahiko Shien, Akihiro Matsukawa

{"title":"The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer.","authors":"Hnin-Wint-Wint Swe, Masayoshi Fujisawa, Toshiaki Ohara, Yu Komatsubara, Teizo Yoshimura, Tadahiko Shien, Akihiro Matsukawa","doi":"10.1111/pin.13442","DOIUrl":"10.1111/pin.13442","url":null,"abstract":"Angiogenesis is considered essential for tumor progression; however, whether histological counting of blood vessel numbers, expressed as microvessel density (MVD), can be a prognostic factor in breast cancer remains controversial. It has been suggested that the specific morphology of blood vessels such as glomeruloid microvascular proliferation (GMP) is associated with clinical parameters. Here, we aimed to clarify the significance of MVD with revised immunohistochemistry and to identify new blood vessel shapes that predict prognosis in breast cancer. Four hundred and eleven primary breast cancer specimens were collected, and the sections were immunohistochemically stained with CD31 (single staining) and CD31 and Collagen IV (double staining). The prognosis of patients was examined based on the MVD value, and the presence of GMP and other blood vessels with other specific shapes. As a result, high MVD value and the presence of GMP were not associated with worse prognosis. By contrast, patients with deep-curved capillaries surrounding tumor cell nests (C-shaped) or excessively branched capillaries near tumor cell nests showed a significantly poor prognosis. The presence of these capillaries was also correlated with clinicopathological parameters such as Ki-67 index. Thus, the morphology of capillaries rather than MVD can be a better indicator of tumor aggressiveness.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"394-407"},"PeriodicalIF":2.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the usefulness of a bile duct biopsy and bile cytology using a hyperspectral camera and machine learning. 利用高光谱照相机和机器学习研究胆管活检和胆汁细胞学检查的实用性。

IF 2.5 4区医学

Pathology International Pub Date : 2024-06-01 Epub Date: 2024-05-24 DOI: 10.1111/pin.13438

Tomoko Norose, Nobuyuki Ohike, Daiki Nakaya, Kentaro Kamiya, Yoshiya Sugiura, Misato Takatsuki, Hirotaka Koizumi, Chie Okawa, Aya Ohya, Miyu Sasaki, Ruka Aoki, Kazunari Nakahara, Shinjiro Kobayashi, Keisuke Tateishi, Junki Koike

引用次数: 0

Regulatory T-cells activated in metastatic draining lymph nodes possibly suppress cancer immunity in cancer tissues of head and neck squamous cell cancer. 转移引流淋巴结中激活的调节性 T 细胞可能会抑制头颈部鳞状细胞癌癌组织中的癌症免疫。

IF 2.5 4区医学

Pathology International Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI: 10.1111/pin.13430

Susumu Suzuki, Toyonori Tsuzuki, Masato Saito, Toshihiko Ishii, Taishi Takahara, Akira Satou, Daisuke Inukai, Shunpei Yamanaka, Kazuhiro Yoshikawa, Ryuzo Ueda, Tetsuya Ogawa

{"title":"Regulatory T-cells activated in metastatic draining lymph nodes possibly suppress cancer immunity in cancer tissues of head and neck squamous cell cancer.","authors":"Susumu Suzuki, Toyonori Tsuzuki, Masato Saito, Toshihiko Ishii, Taishi Takahara, Akira Satou, Daisuke Inukai, Shunpei Yamanaka, Kazuhiro Yoshikawa, Ryuzo Ueda, Tetsuya Ogawa","doi":"10.1111/pin.13430","DOIUrl":"10.1111/pin.13430","url":null,"abstract":"Regulatory T cells (Tregs) play an important role in creating an immunosuppressive microenvironment in cancer tissues. However, the mechanisms by which Tregs are activated and suppress cancer immunity remain unclear. To elucidate these mechanisms, we performed a T cell receptor (TCR) repertoire analysis of Tregs and conventional T cells in peripheral blood, draining lymph nodes (DLNs), and cancer tissues of patients with head and neck squamous cell cancer (HNSCC). We found that the TCR repertoire was skewed in cancer tissue and metastatic DLNs (M-DLNs) compared with non-metastatic DLNs, and TCR repertoire similarities in Tregs and CD8+ T cells between M-DLNs and cancer tissue were high compared with those at other sites. These results suggest that Tregs and CD8+ T cells are activated in M-DLNs and cancer tissues by cancer antigens, such as neoantigens, and shared antigens and Tregs suppress CD8+ T cell function in a cancer antigen-specific manner in M-DLNs and cancer tissue. Moreover, M-DLNs might be a source of Tregs and CD8+ T cells recruited into the cancer tissue. Therefore, targeting Tregs in M-DLNs in an antigen-specific manner is expected to be a novel immunotherapeutic strategy for HNSCCs.","PeriodicalId":19806,"journal":{"name":"Pathology International","volume":" ","pages":"327-336"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of bronchiolar adenoma with their diagnostic difficulties and important clues 两例支气管腺瘤及其诊断困难和重要线索

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-02 DOI: 10.1111/pin.13436

Shinsuke Aida, Yuichi Ishikawa, Mayumi Kaneko

引用次数: 0

Letter to the Editor regarding “Mixed epithelial and stromal tumor synchronously detected in bilateral kidneys with end‐stage renal failure” 致编辑的信，内容涉及 "在终末期肾衰竭的双侧肾脏中同步发现上皮和间质混合瘤"。

IF 2.2 4区医学

Pathology International Pub Date : 2024-05-02 DOI: 10.1111/pin.13434

Begum Calim‐Gurbuz, Tuce Soylemez‐Akkurt, Basak Bekiroglu, Merve Sam Ozdemir, Mehmet Sahin

引用次数: 0