Pharmaceutical nanotechnology最新文献

{"title":"Nano-Pickering Emulsion using Solid Particles of Typhonium flagelliforme Extract as a Stabilizer: Optimization using Response Surface Methodology and Elucidation of Antioxidant and Antibacterial Activities.","authors":"Hetty Lendora Maha, Irda Fidrianny, Satrialdi -, Tri Suciati","doi":"10.2174/0122117385368118250217051038","DOIUrl":"https://doi.org/10.2174/0122117385368118250217051038","url":null,"abstract":"<p><strong>Background: </strong>Typhonium flagelliforme is a plant known for its high polyphenol content, making it a good option for stabilizing nano-Pickering emulsion systems. Nano-Pickering emulsions use solid particles for better stability and functional properties than conventional ones.</p><p><strong>Objective: </strong>This study aimed to develop a nano-Pickering emulsion stabilized by TF particles using the Response Surface Methodology (RSM).</p><p><strong>Methods: </strong>The RSM was used to determine the best formulation and manufacturing process for TFbased nano-Pickering emulsion (TFNPE). The optimal formula was tested for physical stability, in vitro antioxidant activity, and antibacterial activity using the agar diffusion method against several bacteria.</p><p><strong>Results: </strong>The droplet size and distribution of TFNPE were affected by solid particle content, chitosan concentration, and sonication intensity. The optimal formula had 1.84% solid particles, 0.26% chitosan, and 50% sonication intensity. TFNPE remained stable at 4 ± 2°C for six months and showed increased antioxidant capacity (204.76 ± 3.57 mg AEAC/g) relative to TF extract (176.65 ± 2.86 mg AEAC/g). TFNPE also exhibited antibacterial activity against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, with inhibition zones of 12.9 ± 0.5 mm, 14.81 ± 0.1 mm and 16.27 ± 0.3 mm, respectively.</p><p><strong>Conclusion: </strong>The experimental results were well fitted with the selected statistical model. These findings confirmed TFE's ability to act as a stabilizer for Pickering emulsions and determined its significant anti-acne potential due to its antioxidant and antibacterial properties.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosponge Fortified Ciclopirox-Olamine for Antifungal Efficacy with Improved Topical Delivery.","authors":"Megha Gupta, Kuldeep Vinchurkar, Dinesh Mishra, Pankaj Dixit, Sheetal Mane, Sudarshan Singh, Pooja V Nagime","doi":"10.2174/0122117385363568250417003059","DOIUrl":"https://doi.org/10.2174/0122117385363568250417003059","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Topical drug delivery systems are most promising in the management of fungal skin infections; however, they often face challenges to achieve therapeutic efficacy due to low solubility, particle size, molecular weight, and skin barriers. In this regard, nanosponge [NS] offers a novel solution with its three-dimensional porous networks, enhancing drug solubility, bioavailability, and providing prolonged release.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study was to develop NS fortified with Ciclopirox olamine [CPO] with enhanced drug solubility, prolonged targeted delivery, and improved therapeutic efficacy for the management of fungal skin infections.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;CPO-loaded ethyl cellulose and polyvinyl alcohol NS were synthesized using the emulsion solvent technique and subsequently evaluated for particle size, surface morphology through scanning electron microscopy [SEM], polydispersity index [PDI], zeta potential [ZP], entrapment efficiency [EE %], drug loading [DL %], drug-excipient interactions via differential scanning calorimetry, and in vitro dissolution studies. Furthermore, the antifungal test was conducted to assess the inhibitory effect on fungal growth.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The optimized formulation using ethyl cellulose and polyvinyl alcohol at 1.75 mg and 2 mg, respectively, emerged as the most effective, with a particle size of 526.1 nm and PDI of 0.332, indicating a uniform distribution. Moreover, the formulation demonstrated a high drug loading efficiency and sustained drug release over a 7 h period, achieving a drug release of 77.83 %. The pH of the gel formulations ranged from 5.35 to 7.40, the viscosity ranged from 3759 to 4710 cps, and the spreadability was adequate for topical application. Additionally, the optimized NS exhibited superior antifungal activity against Candida albicans and Aspergillus Niger, compared to drug alone and commercial fungicidal creams. Moreover, the in vitro studies confirmed the gel's effectiveness and its ability to sustain drug release, following Higuchi kinetics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The formulated CPO-loaded NS gels exhibit enhanced solubility, stability, and sustained drug release, significantly improving topical drug delivery with exceptional therapeutic efficacy. This novel approach underscores the potential of NSs for efficient and targeted medication delivery in both the pharmaceutical and cosmetic industries. Furthermore, their effective preparation method, excellent physicochemical properties, and antifungal activity make NSs a promising strategy for the oral delivery of poorly soluble drugs. The fungal skin infections are generally not serious but can be uncomfortable and persistent. With proper hygiene and appropriate treatment, most infections can be effectively managed. Therefore, understanding the types of fungi involved and recognizing symptoms early with an effective delivery system can lead to qu","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Preparation Techniques for Polymeric Nanoparticles and their Application in Drug Delivery.","authors":"Harish Bhardwaj, Soniya Sarthi, Rajendra Kumar Jangde","doi":"10.2174/0122117385366838250314110525","DOIUrl":"https://doi.org/10.2174/0122117385366838250314110525","url":null,"abstract":"<p><p>Nanotechnology has advanced significantly in recent decades, with the production and design of nanomaterials becoming a focal point of research. Nanomedicine, a key component of this field, involves the development of nanoscale materials for applications in imaging and drug delivery. Current research predominantly focuses on the synthesis of precisely characterized nanomaterials, particularly in terms of their size and morphology, as these parameters play a critical role in determining the behavior of nanomaterials in vivo. This paper reviews various methods for the preparation of polymeric nanoparticles, including solvent evaporation, nanoprecipitation, emulsification/ solvent diffusion, salting out, dialysis, supercritical fluid technology (SCF), and monomer polymerization techniques. Additionally, it discusses approaches such as emulsion, mini-emulsion, microemulsion, interfacial polymerization, controlled/living radical polymerization, and ionic gelation/ coacervation. Each preparation method is described in terms of its characteristics, advantages, limitations, and potential applications. The paper also explores pharmaceutical considerations and challenges associated with novel drug delivery systems. Recent literature examples are presented to highlight the impact of preparation techniques on the physicochemical properties of nanoparticles.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Nanoparticle-Based Targeted Drug Delivery Systems for Breast Cancer.","authors":"Roshni Kunte, Prafulla Sabale, Suchita Waghmare, Manasi Nikam Jiwankar, Vidya Sabale","doi":"10.2174/0122117385339882241206095441","DOIUrl":"https://doi.org/10.2174/0122117385339882241206095441","url":null,"abstract":"<p><p>Cancer is a leading cause of death and life-threatening disease globally. It is connected to persistent tissue damage and unregulated cellular proliferation. In females, breast cancer plays a crucial role in death rates. Chemotherapy, alongside surgery, radiation, and hormone therapy, is a first-line treatment, but its non-specific action harms both cancerous and healthy cells, causing severe side effects. The treatment options for breast cancer are based on the disease stage, which spans from stages 0 to IV. To mitigate this issue, novel strategies focusing on specific targets have been introduced in recent times. Advanced nanocarriers are focused on tumor-specific drug delivery using active targeting based on ligand-receptor identification, this approach has the potential to demonstrate enhanced efficacy compared to passive targeting strategies in the context of therapy for human breast cancer. Surface alteration can assist overcome this issue. This overview focuses on modified nano-sized carriers, including liposomes, micelles, polymeric nanocarriers, carbon dots, and gold nanoparticles. It has been studied to improve therapeutics efficacy, bioavailability, and pharmacokinetics features via mechanisms. The primary aim is no longer confined to merely enveloping cancer medications in novel formulations for diverse delivery pathways; instead, the emphasis lies on precise cancer targeting. This review focuses on the stages of breast cancer, obstacles, types of breast cancer therapies, techniques, and various nanocarriers using ligand-mediated drug delivery systems and their mechanisms.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Drug Delivery Carriers (Nanocarriers): A Promising Targeted Strategy in Tuberculosis and Pain Treatment.","authors":"Rahul Pal, Prachi Pandey, Himmat Singh Chawra, Zuber Khan","doi":"10.2174/0122117385367493250224103839","DOIUrl":"https://doi.org/10.2174/0122117385367493250224103839","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with significant limitations. In TB, long treatment durations, poor compliance, drug resistance, and toxicity of first-line drugs are key challenges. Similarly, pain management faces issues, such as inadequate targeting, systemic side effects, and tolerance to analgesics, limiting traditional therapy efficacy.</p><p><strong>Objective: </strong>The objective of this review is to explore the potential of nanocarriers as a targeted drug delivery strategy for improving treatment outcomes in TB and pain management. It aims to explore how these advanced systems improve drug bioavailability (BA), control release, reduce side effects, and enhance therapeutic outcomes.</p><p><strong>Methods: </strong>This systematic review used databases like PubMed, Elsevier, Scopus, Google Scholar, Google Patents, and ResearchGate, etc., to collect original review articles from the past 15 years (September 1, 2007 to September 1, 2024).</p><p><strong>Results: </strong>The review also revealed that these advanced systems offer promising solutions for overcoming the limitations of conventional therapies, such as poor patient compliance and drug toxicity. Nanocarriers represent a transformative approach in both TB and pain management, with the potential to revolutionize treatment paradigms and improve patient outcomes.</p><p><strong>Conclusion: </strong>In conclusion, nanocarriers represent a highly promising approach for advancing treatment strategies in both TB and pain management. The review underscores that nanocarrier systems, such as nanoemulsion, nanosuspension, nanocrystal, liposomes, niosomes, dendrimer, and polymeric nanoparticles, offer substantial improvements in drug delivery by enhancing BA, ensuring targeted release, and reducing systemic side effects.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Antidiabetic Potential of Herbal Nanoparticles.","authors":"Kunal Datta, Soubhik Bhattacharyya, Christina Narzary, Reshmi Mukherjee, Angana Naskar, Shazma Imam, Subarno Chakraborty, Dhrubajyoti Sarkar","doi":"10.2174/0122117385357690250214072827","DOIUrl":"https://doi.org/10.2174/0122117385357690250214072827","url":null,"abstract":"<p><p>Diabetes is a chronic metabolic disorder that is characterized by high postprandial blood sugar levels and increased fasting, which disrupts physiological balance and causes organ damage. Owing to the global health risk of type 2 diabetes, natural remedies have shown promise as viable alternatives because of their outstanding antidiabetic properties. Nevertheless, the therapeutic use of these compounds is rather restricted due to their inadequate solubility, instability in the gastrointestinal tract, low absorption, and other related factors. Currently, the development of nanoscale systems is a notable approach to enhancing the delivery of phytochemicals. This study aims to investigate the advancements in drug delivery techniques using nanoparticles, with a particular focus on enhancing the effectiveness of herbal remedies in the treatment of diabetes. This study aims to enrich our understanding of nanotechnology's potential in enlightening drug delivery systems by employing database repositories like PubMed, Scopus, Google Scholar, and Web of Science. Based on their categorization and structure, nano-systems are classified into liposomes, nanostructured lipid carriers, phytosomes, niosomes, solid lipid nanoparticles, self-nano emulsifying drug delivery systems, and inorganic nano-carriers. This study intricately describes the formulation process, selection criteria, and mechanism of herb-loaded nanoparticles using an example of the pharmacokinetic and pharmacodynamic properties of antidiabetic herbal drugs. Researchers have proven that nanoformulations of herb-loaded antidiabetic drugs improve compliance and therapeutic efficacy by resolving pharmacokinetic and biopharmaceutical issues. We could expect the creation of nanoformulations to be a viable method for optimizing the therapeutic effectiveness of plant-produced antidiabetic compounds.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diosgenin-Loaded Silver Nanoparticles Mitigate B[a]P-Induced Lung Fibrosis Through Modulation of Oxidative Stress and Inflammatory Pathways.","authors":"Ahmed Salah, Maiven M Edward, Mohammed A Hussein, Tamer Roshdy, Mohamed S Basiouny","doi":"10.2174/0122117385337401250116040312","DOIUrl":"10.2174/0122117385337401250116040312","url":null,"abstract":"<p><strong>Background: </strong>Lung fibrosis, characterized by the thickening and scarring of lung tissue, is a serious condition often triggered by environmental toxins like Benzo[a]pyrene (B[a]P). Diosgenin, a natural steroidal sapogenin found in plants such as fenugreek and wild yam, has shown potential to protect against lung damage due to its anti-inflammatory and antioxidant properties. However, its clinical application is limited by poor solubility and bioavailability.</p><p><strong>Objective: </strong>The current investigation aims at developing diosgenin-loaded silver nanoparticles (DioAgNPs) to enhance their delivery and efficacy. This study investigates the preparation, characterization, and protective effects of Dio-AgNPs against B[a]P-induced lung fibrosis in mice.</p><p><strong>Methods: </strong>Acute toxicity studies in mice were conducted to determine the lethal dose (LD50) of DioAgNPs. Sub-lethal doses (1/50 and 1/20 LD50) were selected for subsequent experiments. Mice were exposed to B[a]P to induce lung fibrosis. Dio-AgNPs were administered to assess their protective effects. Biochemical assays measured levels of total cholesterol (TC), triglycerides (TG), malondialdehyde (MDA), nuclear factor kappa B (NF-κB), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP2), and matrix metalloproteinase-12 (MMP12). Additionally, high-density lipoprotein cholesterol (HDL-C), glutathione (GSH), catalase (CAT), and glutathione peroxidase (GPx) levels were evaluated. Quantitative PCR (qPCR) was used to analyze the expression levels of lung signal transducer and activator of transcription 3 (STAT3), transforming growth factor- β1(TGF-β1), and Sirtuin 1 genes. Insilico molecular docking studies were performed to evaluate the binding affinity of diosgenin with SIRT1, STAT3, and TGF-β1 proteins, with binding energies (ΔG) calculated to predict interaction strength.</p><p><strong>Results: </strong>The synthesized Dio-AgNPs exhibited a mean diameter of 51.60±1.54 nm, a zeta potential of -19.5 mV, and encapsulation efficiency of 84.98%, confirming their stability through spectral analysis. In B[a]P-exposed mice, there was a significant elevation in TC, TG, MDA, NF-κB, IL-6, MMP2, and MMP12 levels, alongside a reduction in HDL-C, GSH, CAT, and glutathione peroxidase (GPx) levels. Additionally, lung STAT3 and TGF-β1 gene expression was upregulated, while SIRT1 gene expression was downregulated. Administration of Dio-AgNPs to B[a]P-treated mice resulted in a significant reduction in TC, TG, and HDL-C levels, improvement in lung MDA, NF-κB, IL-6, MMP2, and MMP12 levels, downregulation of lung STAT3 and TGF-β1, and upregulation of SIRT1 gene expression. In-silico molecular docking studies demonstrated strong binding affinities of diosgenin with SIRT1, STAT3, and TGF-β1 proteins, with binding energies (ΔG) of -9.7, -9.6, - 10.1, and -9.7 kcal/mol, respectively.</p><p><strong>Conclusion: </strong>This study innovatively enhances the delivery and efficac","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crocin and Nano-Crocin Mitigate Paraquat Hepatotoxicity by Modulating Expression of Genes Involved in Oxidative Stress and Inflammation.","authors":"Zahra Khaksari, Freshteh Mehri, Mohadeseh Haji Abdolvahab, Mohammad Amin Manavi, Mohammad Hosein Fathian Nasab, Ashkan Karbasi, Maryam Baeeri, Akram Ranjbar","doi":"10.2174/0122117385323941241211084423","DOIUrl":"https://doi.org/10.2174/0122117385323941241211084423","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Crocin, a natural compound found in saffron, has shown promising potential as an anti-inflammatory and antioxidant agent. Paraquat is a widely used herbicide known to cause severe oxidative stress and inflammation in the liver, leading to significant tissue damage. This study explores the potential of crocin and its nanoformulation for mitigating paraquat-induced liver damage associated with inflammation and oxidative stress.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The experimental design included 30 male Wistar rats divided into a control group, a paraquat group (5 mg/kg/day for 1 week, i.p.), and four treatment groups: crocin (20 mg/kg/day for 1 week, i.p.), nano-crocin (20 mg/kg/day for 1 week, i.p.), crocin+paraquat, and nano-crocin+paraquat. The levels of TNF-α, IL-1β, and NF-κB mRNA, reactive oxygen species (ROS), lipid peroxidation (LPO) generation, thiol level, and superoxide dismutase (SOD) activity were assessed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;According to the results, the TNF-α, IL-1β, and NF-κB mRNA levels, as well as LPO and ROS generation increased following paraquat administration. Furthermore, both treatment groups showed significantly lower levels compared to the paraquat group (p&lt;0.0001), with the nano-crocin group showing the most significant reduction (p&lt;0.0001). On the other hand, reduced thiol level and SOD activity in the paraquat group were significantly attenuated by crocin and nano-crocin administration (p&lt;0.0001). Notably, nano-crocin exhibited superior protective effects, with a greater reduction in inflammatory markers and oxidative stress indicators compared to crocin (p&lt;0.01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This study provides strong evidence that nano-crocin offers superior hepatoprotective effects over crocin in mitigating paraquat-induced liver injury by reducing oxidative stress and inflammation. The results suggest that nano-crocin could be a promising candidate for the development of novel antioxidant therapies targeting liver diseases characterized by oxidative stress. The study further elucidates the underlying mechanisms of action, highlighting the role of nano-crocin in modulating inflammatory pathways and enhancing antioxidant defenses, which may be attributed to its improved bioavailability and targeted delivery. Future studies should focus on the long-term safety and efficacy of nano-crocin, as well as exploring its potential applications in other models of liver injury and systemic oxidative stress-related diseases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In conclusion, nano-crocin treatment exerted more protective effects than crocin on the liver against inflammation and oxidative stress induced by paraquat. These findings suggest that nano-crocin could serve as a promising therapeutic candidate for the management of liver diseases characterized by oxidative stress and inflammation. Future studies should focus on exploring the long-term safety and efficacy of na","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metallic Nanostructures: An Updated Review on Synthesis, Stability, Safety, and Applications with Tremendous Multifunctional Opportunities.","authors":"Pooja V Nagime, Nishat M Shaikh, Sudarshan Singh, Vaishali S Chandak, Vijay R Chidrawar, Eloise Parry Nweye","doi":"10.2174/0122117385358312250108180301","DOIUrl":"https://doi.org/10.2174/0122117385358312250108180301","url":null,"abstract":"<p><p>Metallic nanostructures play a vital role in technological advancement, providing exceptional performance and improved adaptability in comparison to their bulk equivalents. Conventional synthesis techniques frequently depend on dangerous reducing agents to transform metal ions into Nanoparticles (NPs), which presents considerable environmental and health issues. In contrast, the approach of green synthesis, which emphasizes the use of non-toxic reagents, has garnered significant interest as a sustainable method for the fabrication of Metallic Nanoparticles (MNPs). This sustainable approach utilizes biological sources, like actinomycetes, algae, fungi, polymers, crops, waste biomass, and yeast, recognized for their excellent biocompatibility, availability, affordability, and efficiency. Biological extracts act as reducing and stabilizing agents, with the metabolites and enzymes present in these extracts aiding in the conversion of metal ions into nanoparticles. This review offers an in-depth examination of different MNPs, such as copper, gold, platinum, silver, and zinc, emphasizing their distinct characteristics and a variety of synthesis methods. The review further explores the diverse applications of MNPs in biomimetics, agriculture, and various industrial sectors, including energy, catalysis, and wastewater treatment, along with optical enhancement. This review explores stability and toxicity profiles, filling a significant gap in the existing knowledge base and providing valuable insights into the broad applicability of MNPs.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing Drug Delivery: A Design Professional's Approach to Drug-loaded Transferosomal Vesicles for Transdermal Use.","authors":"Gopinath Subramaniyan, Rubina Shaik, Bachu Venkata Ramana, Meriton Stanley A, Devasena Srinivasan","doi":"10.2174/0122117385346215250109142123","DOIUrl":"https://doi.org/10.2174/0122117385346215250109142123","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to develop and evaluate lornoxicam (LXM) and thiocolchicoside (TCS) transferosomal transdermal patches.</p><p><strong>Background: </strong>Oral administration of LXM and TCS can lead to gastric irritation, necessitating alternative delivery methods for pain and inflammation relief. Incorporating LXM & TCS into transferosomes within a transdermal patch offers a potential solution.</p><p><strong>Objective: </strong>The objective of this study is to develop and evaluate transferosomal transdermal patches containing LXM and TCS, incorporating Aloe vera leaf mucilage (AVLM) and lime oil (LO) as permeability enhancers. The aim is to enhance the skin permeation of these drugs while mitigating gastric irritation associated with their oral administration.</p><p><strong>Method: </strong>Transferosomes were made by the thin film hydration tactic, with nine formulations based on three independent variables: phosphatidylcholine, span 80, and sonication time. Entrapment efficiency and drug release at 6th h were assessed as dependent variables. The optimized combination was then formulated into transdermal patches via central composite design, evaluating the impact of AVLM and LO on lornoxicam discharge and other physicochemical properties.</p><p><strong>Results: </strong>The average weight and thickness of the patches ranged from 7.52±0.75 to 8.07±0.11g and from 1.69±0.01 to 1.82±0.02mm, respectively, representing minimal variance. The LXM/TCS content homogeneity ranged from 92.84±3.55 to 94.07±4.61% for LXM and from 90.17±1.98 to 93.18±2.98% for TCS, demonstrating robust uniformity. Higher proportions of phosphatidylcholine and span 80, along with lesser sonication time, led to improved entrapment of lornoxicam. In vitro, discharge studies demonstrated optimal discharge with a higher proportion of phosphatidylcholine, a medium proportion of span 80, and a longer sonication time. The transferosomal patches exhibited zero-order discharge kinetics, with LXM & TCS discharge % at 24, 48, and 72 h.</p><p><strong>Conclusion: </strong>The study concludes that formulation TDP-8, which incorporates 3g of Aloe vera leaf mucilage (AVLM) and lime oil (LO) as permeability enhancers, demonstrated favorable discharge characteristics. This indicates its potential as an effective transdermal delivery system for LXM and TCS, offering a promising substitute for pain and inflammation relief while minimizing gastric irritation. The study succeeded in developing and evaluating transferosomal transdermal patches for LXM and TCS, providing an alternative delivery method that minimizes gastric irritation.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}