Mohammed Alsharafi, Yusuf Zeren, Haifa Ahmed, Abdu Alameri
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The Second Hyper-Zagreb Index and Coindex of Chemical Nanostructures in Drugs.
Introduction: Various dendrimer nanoparticles have properties like multivalency, controlled size, and surface functionality that make them promising nanocarriers for targeted drug delivery and other applications in pharmaceutical sciences. The precise tunability of dendrimers is an advantage over other nanoparticles. The topological descriptors can be used to predict the physicochemical properties of dendrimers and optimize their branching pattern for specific applications. The second hyper-Zagreb index and co-index are computed for various chemical structures, including dendrimers, to facilitate the correlation between their structure and biological activity.
Method: In this study, the second Hyper-Zagreb index and second Hyper-Zagreb polynomials were calculated for various chemical structures, such as the molecular graph of poly(propyl) ether imine dendrimer PETIM, nanostar dendrimer (D3[p]), polypropylenimine octaamine dendrimer (NS1[p]) and (NS2[p]), polymer dendrimer (NS3[p]) and NS5[p]), fullerene dendrimer (NS4[p]), and other classes of dendrimers.
Result: By computing formulae and analyzing data and figures, we obtained new insights into the features of structure-property connections for these types of compounds of nanostar dendrimers.
Conclusion: The results can be used to optimize the properties of dendrimers for specific applications.
期刊介绍：
Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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