Pathogens最新文献

{"title":"Differential Gene Expression and Protein-Protein Interaction Networks in Bovine Leukemia Virus Infected Cattle: An RNA-Seq Study.","authors":"Ana S González-Méndez, Mohammad Mehdi Akbarin, Fernando Cerón-Téllez, Gabriel Eduardo Acevedo-Jiménez, Cecilia Rodríguez-Murillo, Víctor David González-Fernández, Lucero de María Ávila-De la Vega, Marisela Leal-Hernández, Hugo Ramírez Álvarez","doi":"10.3390/pathogens14090887","DOIUrl":"10.3390/pathogens14090887","url":null,"abstract":"<p><strong>Introduction: </strong>Bovine leukemia virus is a single-stranded RNA virus that targets B cell CD5⁺ lymphocytes in cattle. Only a tiny percentage of individuals develop malignant lymphoproliferative disorders, while most remain healthy carriers or experience persistent lymphocytosis. The exact mechanisms leading to lymphoma development are complex and not fully understood. RNA-seq analysis of cows' peripheral blood leukocytes (PBLs) with and without Bovine leukemia virus (BLV) antibodies was conducted to gain a deeper understanding of molecular events beyond BLV infection.</p><p><strong>Method: </strong>Eighteen samples were selected, and their RNA was sequenced. For gene expression analysis and protein-protein network interactions, three groups were selected, including healthy negative samples (CT, n = 7), asymptomatic carriers (AC, n = 5), and persistent lymphocytosis (PL, n = 6), to provide the differentially expressed gene (DEG) and protein-protein interaction network (PPIN) outputs.</p><p><strong>Results: </strong>Our results demonstrated that in comparison to CT, ACs upregulated TLR7 and transcription activation factors. In the CT vs. PL group, <i>MHC class II</i>, transcription activation factors, and anti-inflammatory cytokines increased, while the acute-phase proteins, antiviral receptors, and inflammatory cytokines decreased. Additionally, antiviral receptors, acute-phase proteins, and inflammatory receptors were downregulated in the PL versus the AC groups. Moreover, PPINs analysis suggested that nuclear receptor corepressor 1 (NCOR1), serine/arginine repetitive matrix 2 (SRRM2), LUC7 like 3 pre-mRNA splicing factor (LUC7L3), TWIST neighbor (TWISTNB), U6 small nuclear RNA and mRNA degradation associated (LSM4), eukaryotic translation elongation factor 2 (EEF2), ubiquitin C (UBC), CD74, and heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNP A2B1) are possible hub gene candidates in the PL group.</p><p><strong>Conclusions: </strong>Our results suggest that innate and cellular immune responses are more loose in severe BLV infectious conditions, while the PPINs revealed that new protein interactions are necessary for oncogenesis.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Compounds from <i>Tithonia diversifolia</i> Aerial Parts Against Eggs and Infective Larvae of the Parasitic Nematode <i>Haemonchus contortus</i>.","authors":"Jorge Alberto Cortes-Morales, Agustín Olmedo-Juárez, Victoria Michelle Tapia-Molina, Manases González-Cortazar, Alejandro Zamilpa, Pedro Mendoza-de Gives, Abel Villa-Mancera, Bernardo Sachman-Ruiz, Filiberto Anzures Olvera","doi":"10.3390/pathogens14090884","DOIUrl":"10.3390/pathogens14090884","url":null,"abstract":"<p><p>Small ruminant production under grazing conditions plays a crucial role in the global primary sector economy. However, these animals are highly susceptible to gastrointestinal nematodes (GINs), which significantly impact their health and welfare. Given the increasing resistance to conventional anthelmintics, there is a pressing need to explore sustainable alternatives, such as plant secondary metabolites. This study aimed to identify phenolic compounds with anthelmintic activity from <i>Tithonia diversifolia</i> aerial parts, using <i>Haemonchus contortus</i> as a biological model. Egg hatching inhibition (EHI) and larval mortality assays were used to evaluate the anthelmintic activity of a hydroalcoholic extract (HA-E), an aqueous (Aq-F) and ethyl acetate fraction (EtOAc-F), and eight bioactive subfractions (TdR1-TdR8) obtained from EtOAc-F. The identification of major compounds was performed using HPLC-PDA. The E-HA and EtOAc-F achieved 100% EHI at 40 and 4 mg/mL, respectively. The subfractions TdR2 (EC₉₀ = 0.55 mg/mL), TdR3 (EC₉₀ = 0.12 mg/mL), and TdR4 (EC₉₀ = 0.26 mg/mL) exhibited the highest ovicidal activity. In the larval mortality test, EtOAc-F showed an LC₈₅ of 56.74 mg/mL. The major identified compounds included cinnamates, hydroxycinnamic acids (e.g., caffeic acid and chlorogenic acid), gallates, flavonoids (flavones and flavanones), and coumarins. These findings support the potential of <i>T. diversifolia</i> as a promising natural source for the control of GINs in small ruminants.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological Quality and Presence of Clinically Relevant Nontuberculous Mycobacteria in Purified Water from Vending Machines in Michoacan, Mexico.","authors":"Ricardo Jiovanni Soria-Herrera, Janet Karina Hernández-Ramón, Marco Esteban Álvarez-Pérez, Miriam Alejandra Pérez-Sandoval, Margarita Hernandez-Mixteco, Olga Lidia Valenzuela, Eliud Alfredo Garcia-Montalvo, Paola Castillo-Juárez, Sandra Rivera-Gutiérrez, Gilberto Cornejo-Estudillo, Moises León-Juárez, Addy Cecilia Helguera-Repetto, Victoria Campos-Peña, Ma Guadalupe Zanella-Vargas, Graciela Castro-Escarpulli, Carlos Cortes-Penagos, Jorge Francisco Cerna-Cortés","doi":"10.3390/pathogens14090886","DOIUrl":"10.3390/pathogens14090886","url":null,"abstract":"<p><p>In this study, 104 purified water samples were collected from vending machines in the three main cities of Michoacan, Mexico, to assess microbiological quality and the occurrence of diarrheagenic <i>Escherichia coli</i> pathotypes (DEP) and nontuberculous mycobacteria (NTM). Aerobic mesophilic bacteria were detected in all samples, with concentrations ranging from 0.95 to 3.71 log₁₀ CFU/mL. A total of 62, 34, and 25 samples tested positive for total coliforms, fecal coliforms, and <i>E. coli</i>, respectively. Sixty-two samples exceeded Mexico's official guideline. None of the 58 <i>E. coli</i> strains isolated from the 25 <i>E. coli</i>-positive samples belonged to DEP. NTM species were recovered from 47 samples, including <i>M. mucogenicum</i> (n = 18), <i>M. abscessus</i> (n = 11), <i>M. chelonae</i> (n = 7), <i>M. porcinum</i> (n = 3), <i>M. fortuitum</i> (n = 2), <i>M. septicum</i> (n = 1), <i>M. phocaicum</i> (n = 1), and <i>M. brisbanense</i> (n = 1). Three additional isolates could not be identified. All NTM strains produced biofilm and exhibited sliding motility. These findings highlight significant microbiological risks associated with vending machine water and underscore the need for manufacturers to ensure regular maintenance to provide safe and reliable purified water to consumers.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc Acetate Inhibits Hepatitis A Virus Replication: Possible Treatment for Patients with Type A Acute-on-Chronic Liver Failure.","authors":"Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroyuki Abe, Takeshi Yokoo, Akira Sakamaki, Kazunao Hayashi, Hiroteru Kamimura, Atsunori Tsuchiya, Ryota Masuzaki, Hirofumi Kogure, Hiroaki Okamoto, Shuji Terai","doi":"10.3390/pathogens14090882","DOIUrl":"10.3390/pathogens14090882","url":null,"abstract":"<p><p>Hepatitis A virus (HAV) infection sometimes results in the occurrence of acute liver failure and acute-on-chronic liver failure (ACLF), which is often fatal, especially in patients with diabetes mellitus or elderly individuals. ACLF is observed in patients with cirrhosis who occasionally have zinc deficiency. However, effective drugs for hepatitis A are currently unavailable. Glucose-regulated protein 78 (GRP78) is an antiviral agent that has been reported to prevent HAV replication. The effects of zinc acetate on HAV HA11-1299 genotype IIIA replication and changes in GRP78 levels in human hepatocytes with or without HAV infection were examined. Zinc acetate inhibited HAV HA11-1299 genotype IIIA replication in both Huh7 and GL37 cells. Zinc acetate also inhibited HAV replication in both low- and high-glucose media. Zinc acetate increased the expression of GRP78, in response to HAV replication. The combination of zinc acetate with ribavirin led to greater suppression of both HAV HA11-1299 genotype IIIA and HAV HM175/18f genotype IB replication in Huh7 cells than that of ribavirin alone. In conclusion, zinc acetate inhibits HAV replication in accompany with the elevation of GRP78 expression without causing cellular toxicity. Zinc compounds may be useful for the treatment of ACLF caused by HAV infection.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Risk Factors and Production Practices Associated with Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Positivity on Pig Farms in Jalisco, Mexico.","authors":"Alberto Jorge Galindo-Barboza, José Francisco Rivera-Benítez, Jazmín De la Luz-Armendáriz, José Iván Sánchez-Betancourt, Jesús Hernández, Suzel Guadalupe Sauceda-Cerecer, Jaime Enrique De Alba-Campos","doi":"10.3390/pathogens14090881","DOIUrl":"10.3390/pathogens14090881","url":null,"abstract":"<p><p>The modernization of pig farming has resulted in increasingly dense pig populations. While this accelerates production and ensures a steady pork supply, it also increases the risk of infection transmission. As an endemic and widely distributed pathogen, porcine reproductive and respiratory syndrome virus (PRRSV) type 2 can cause disease, depending on the production practices implemented. This study evaluated pig production conditions in Jalisco, Mexico, as well as how these conditions correlated with PRRSV detection. In total, 4207 serum samples obtained from 80 pig farms were subjected to analysis, and epidemiological information was collected to evaluate potential determinants of PRRSV presence. Positive samples were most frequently found in pigs up to 10 weeks of age, raised in semi-intensive, intensive, farrow-to-finish farm, and multisite systems, with relative frequency values ranging from 58.6% to 76.9%. The results revealed that various production practices, particularly related to biosecurity protocols, were associated with the presence of PRRSV on the farms evaluated.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tick Infestation on Milk Yield, Blood Biochemistry, Hematology, and the Overall Health of Dairy Cows.","authors":"Mona Al-Shammari, Ibrahim O Alanazi, Mohammad Alzahrani, Samiah Alotaibi, Nora Alkahtani, Almaha Alaqil, Ebtesam Al-Olayan","doi":"10.3390/pathogens14090883","DOIUrl":"10.3390/pathogens14090883","url":null,"abstract":"<p><p>Tick infestation represents a significant constraint on livestock productivity in Saudi Arabia; however, there remains a substantial gap in research addressing tick species diversity, distribution, and their direct effects on milk production. This study aimed to morphologically and molecularly identify tick species infesting dairy cattle, quantify the impact of tick infestation on milk yield and composition, and contribute to the limited understanding of tick ecology and its economic implications in the region. Ticks were collected from infested cows and identified morphologically using taxonomic keys. Molecular identification was performed via PCR amplification of <i>the mitochondrial cytochrome c oxidase subunit I (COI)</i> gene. Milk production and quality parameters were assessed in tick-infested and healthy cows in Hafar Al-Batin, Eastern Saudi Arabia. Morphological and genetic analyses confirmed <i>Hyalomma anatolicum</i> as the predominant tick species in the study area, with COI sequences showing high similarity to regional isolates. Tick-infested cows exhibited substantial reductions in milk yield, fat, calcium, and potassium levels, indicating significant metabolic disruptions. Blood biochemical analysis revealed elevated levels of liver enzymes [aspartate aminotransferase (AST) increased by 238.6%, gamma-glutamyl transferase (GGT) by 155.7%], renal markers [creatinine increased by 788.9%, urea by 130.0%], and electrolyte imbalances [serum calcium decreased by 39.5%, potassium by 45.2%]. Hematological findings included increased white blood cell (WBC) and red blood cell (RBC) counts by 44.9% and 124.7%, respectively, along with a 53.1% decrease in hemoglobin (HGB), suggesting a systemic inflammatory response and possible anemia. This study is among the first to genetically confirm the presence of <i>H. anatolicum</i> in Hafar Al-Batin using molecular tools, thereby enhancing the accuracy of species-level identification and highlighting the physiological impact of tick burden on dairy productivity.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden and Incidence Trends in Cancers Associated with Human Papillomavirus Infection: A Population-Based Systematic Study.","authors":"Xiaojun Meng, Bolin Yang, Hanlu Yin, Jibiao Chen, Wenjuan Ma, Zhuping Xu, Yuan Shen","doi":"10.3390/pathogens14090880","DOIUrl":"10.3390/pathogens14090880","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is responsible for a substantial fraction of anogenital and head and neck cancers (HNC). HPV-related cancers cause a heavy burden globally, with disparities across different cancers. We aimed to present an up-to-date global view of the patterns and incidence trends among HPV-related cancers.</p><p><strong>Methods: </strong>We collected data on HPV-related cancers from the GLOBOCAN 2022 database and the Cancer Incidence in Five Continents plus Compendium. Age-standardized incidence and mortality rate (ASIR and ASMR) were calculated to estimate the cancer burden. Spearman's correlation tests were used to evaluate the associations with the Human Development Index (HDI). Joinpoint regression was conducted to evaluate the incidence trends in ASIR.</p><p><strong>Results: </strong>In 2022, 1,505,394 HPV-related cancer cases and 755,303 deaths were newly estimated worldwide, corresponding to an overall ASIR and ASMR of 20.9 and 10.2 per 100,000 people, respectively. Africa had the highest ASIR and ASMR compared with Asia, accounting for the most new cases and deaths. The primary cause was cervical cancer (ASIR 14.1 per 100,000 people); however, HNC exhibited the largest number of cases (685,204 cases). The total rates of HPV-related cancers were 1.3 times higher for ASIR and nearly three times higher for ASMR in low-HDI countries than in very high-HDI countries. A decreasing trend was observed for the ASIR of cervical cancer in most studied countries, compared to the increasing trends in HNC in females and anal cancer in both sexes.</p><p><strong>Conclusions: </strong>The global burden and trends of HPV-related cancers vary significantly among different cancer types according to region and sex. Particularly, cervical, HNC, and anal cancers should attract global attention. However, specific cancer types contributing to the heaviest burden should be identified at the country level to adjust resource allocation and improve access to quality health services.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of (Dithioperoxo)thiolate-Based Antifungal Agents for Triazole-Resistant <i>Aspergillus Fumigatus</i>.","authors":"Surya Karuturi, Kaitlyn L Jobe, Melinda E Varney, Michael D Hambuchen, A R M Ruhul Amin, Timothy E Long","doi":"10.3390/pathogens14090878","DOIUrl":"10.3390/pathogens14090878","url":null,"abstract":"<p><p>This investigation on novel antifungal agents featuring a thiol-reactive (dithioperoxo)thiolate chemical nucleus [-NC(S)S-SR] established that the optimal levels of fungal growth inhibition were achieved with thiomethyl-bound derivatives (R = Me). The most efficacious analogs had MIC₅₀/MIC₉₀ values of 2/2 µg/mL and an MIC range of 1 to 2 µg/mL for a ten-member panel of voriconazole-resistant <i>A. fumigatus</i> mutants. Pharmacodynamic studies revealed that the lead (dithioperoxo)thiolates impaired conidial germination and germling development more effectively than voriconazole for the triazole-resistant strain AR-1295. Moreover, glutathione and Cu²⁺ were shown to have antagonistic interactions, which was attributed to the thiol-reactive, pro-oxidant properties of the (dithioperoxo)thiolates and their metabolic conversion to chelating agents. Cytotoxicity studies further showed that the compounds were less toxic to human fetal kidney cells than squamous carcinoma cells. The collective findings of the investigation indicate that (dithioperoxo)thiolates are effective antifungal agents against <i>A. fumigatus</i> to merit additional research on their therapeutic potential.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145176600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights into the Pathogenesis of Experimental Cytomegalovirus Retinal Necrosis with an Emphasis on Inflammasomes and Pyroptosis.","authors":"Richard D Dix, Jessica J Carter, Heather Koehler, Hongyan Guo","doi":"10.3390/pathogens14090879","DOIUrl":"10.3390/pathogens14090879","url":null,"abstract":"<p><p>Pyroptosis is a programmed cell death pathway that initiates and sustains inflammation to protect the host against invading pathogens or stress. Activation of caspase-1-mediated canonical pyroptosis takes place via formation of multi-protein cytoplasmic immune signaling complexes known as inflammasomes. Because we have shown previously that the canonical pyroptosis pathway plays a significant role in the pathogenesis of experimental murine cytomegalovirus (MCMV) retinal necrosis in mice with retrovirus-induced immunosuppression (MAIDS), we performed additional studies to determine whether this pathogenic involvement extends to inflammasomes as initiators of the canonical pyroptosis pathway. Initial studies demonstrated significant transcription of three different pyroptosis-associated inflammasomes, NLRP3, NLRP1b, and AIM2, within the ocular compartments of MCMV-infected eyes of MAIDS mice. Subsequent histopathologic findings revealed MCMV-infected eyes of groups of NLRP3^-/- MAIDS mice, NLRP1b^-/- MAIDS mice, or AIM2^-/- MAIDS mice each exhibited a similar atypical retinal pathology characterized by loss of photoreceptors and proliferation and/or loss of retinal pigmented epithelium but with relative sparing of the neurosensory retina, an outcome different from typical full-thickness retinal necrosis of MCMV-infected eyes of wildtype MAIDS mice. We conclude that multiple inflammasomes are individually stimulated within MCMV-infected eyes of MAIDS mice and each independently contributes to MAIDS-related MCMV full-thickness retinal necrosis pathogenesis.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment.","authors":"Jianchang Huang, Ailin Zhang, Jialin Sun, Yuhan Fu, Weinan Li, Yanhong Wang","doi":"10.3390/pathogens14090874","DOIUrl":"10.3390/pathogens14090874","url":null,"abstract":"<p><p>Malignant tumors have become one of the most important diseases threatening human life and health, and the prevention and treatment of cancer have always been the direction of modern medicine's continuous exploration. According to modern medical research, a tumor microbial ecosystem exists in all human cancers. With the continuous deepening of research on the tumor microenvironment (TME), it has been discovered that some specific bacteria cause tumor production and development by damaging DNA, activating oncogenic signaling pathways, suppressing anti-tumor immunity, and producing pro-tumor metabolites. Certain bacteria associated with tumors can also serve as breakthroughs in the prevention and treatment of tumors. In this review, we present and summarize evidence from a large number of studies on the effects of oncobacteria on tumor prevention and treatment, and we further discuss the direction in which oncobacteria can be positively and effectively used in tumor therapy.</p>","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":"14 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}