Pathogens最新文献_第8页

Hepatitis C Virus Infection in Europe. 欧洲的丙型肝炎病毒感染情况。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100841

Margarida Simão, Cristina Gonçalves

{"title":"Hepatitis C Virus Infection in Europe.","authors":"Margarida Simão, Cristina Gonçalves","doi":"10.3390/pathogens13100841","DOIUrl":"https://doi.org/10.3390/pathogens13100841","url":null,"abstract":"The Hepatitis C Virus (HCV) is a significant public health challenge in European countries. Historically, healthcare-related procedures were the primary source of HCV infection in Europe. However, with the implementation of blood safety programs, injection drug use has become the main transmission route. The infection's distribution and genotype prevalence vary widely across the continent. Even with the availability of highly effective direct-acting antiviral (DAA) therapies, HCV infection is far from being controlled. A significant proportion of patients remain undiagnosed, contributing to the ongoing transmission of the virus. Additionally, several barriers hinder the widespread use of DAAs, including high treatment costs, stigma, poor linkage to care, and considerable geographical variations in prevalence and transmission routes. The World Health Organization has set ambitious targets to reduce liver-related deaths, decrease new viral hepatitis infections, and ensure that 90% of infected individuals are diagnosed by 2030. However, most European countries face challenges, highlighting the need for screening programs, funding mechanisms, and public health strategies to effectively control HCV infection in Europe.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerotolerancy of Campylobacter spp.: A Comprehensive Review. 弯曲杆菌属的耐气性：全面回顾。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100842

Elise Delaporte, Anand B Karki, Mohamed K Fakhr

{"title":"Aerotolerancy of Campylobacter spp.: A Comprehensive Review.","authors":"Elise Delaporte, Anand B Karki, Mohamed K Fakhr","doi":"10.3390/pathogens13100842","DOIUrl":"https://doi.org/10.3390/pathogens13100842","url":null,"abstract":"Campylobacter spp. constitute a group of microaerophilic bacteria that includes strains that are aerotolerant and capable of surviving in aerobic conditions. Recent studies have shown that aerotolerant strains are highly prevalent in meats, animals, and clinical settings. Changes in growth media and other environmental conditions can affect the aerotolerance of Campylobacter strains and must be considered when studying their aerotolerance in vitro. Polymicrobial interactions and biofilms also play a significant role in the ability of Campylobacter to survive oxygen exposure. Continuous subculturing may foster aerotolerance, and studies have demonstrated a positive correlation between aerotolerance and virulence and between aerotolerance and the ability to survive stressful environmental conditions. Various mechanisms and genetic origins for aerotolerance have been proposed; however, most of the potential genes involved in aerotolerance require further investigation, and many candidate genes remain unidentified. Research is also needed to investigate if there are any clinical implications for Campylobacter aerotolerance. Understanding the aerotolerance of Campylobacter remains an important target for further research, and it will be an important step towards identifying potential targets for intervention against this clinically important food-borne pathogen.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis-A Retrospective, Multicenter Study. 咽炎患者的 A 群链球菌感染频率和抗生素使用分析--一项回顾性多中心研究。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100846

Martyna Biała, Mateusz Babicki, Wojciech Malchrzak, Sandra Janiak, Dominik Gajowiak, Alan Żak, Karolina Kłoda, Piotr Gibas, Justyna Ledwoch, Anna Myśliwiec, Daria Kopyt, Anna Węgrzyn, Brygida Knysz, Patrycja Leśnik

{"title":"Frequency of Group A Streptococcus Infection and Analysis of Antibiotic Use in Patients with Pharyngitis-A Retrospective, Multicenter Study.","authors":"Martyna Biała, Mateusz Babicki, Wojciech Malchrzak, Sandra Janiak, Dominik Gajowiak, Alan Żak, Karolina Kłoda, Piotr Gibas, Justyna Ledwoch, Anna Myśliwiec, Daria Kopyt, Anna Węgrzyn, Brygida Knysz, Patrycja Leśnik","doi":"10.3390/pathogens13100846","DOIUrl":"https://doi.org/10.3390/pathogens13100846","url":null,"abstract":"Streptococcus pyogenes is responsible for 20-30% of pharyngitis in children and 5-15% in adults. The ineffective treatment of group A Streptococcus (GAS) infections can result in postinfectious sequelae. This study aims to evaluate the frequency of GAS pharyngitis and assess the management of patients with pharyngitis and antibiotic use. We conducted a multicenter, retrospective analysis of medical records from nine primary care centers in Poland. The study enrolled 1949 medical records of patients (children 67.4%, adults 32.6%). An infection of Streptococcus pyogenes, based on a rapid strep test, was diagnosed in 830 patients (42.6%). In the comprehensive study group of 1949 patients, 1054 (54.1%) were given antibiotics. Notably, 224 patients had a negative rapid strep test result but still received antibiotic treatment, underscoring the complexity of treatment decisions. The most commonly used antibiotics were oral penicillin V in 431 cases (41%) and amoxicillin in 219 cases (20.8%). We observed no significant difference between positive rapid strep test results and patients' sociodemographic data and comorbidities. The prevalence of GAS was 42.6% in the analyzed records of patients with pharyngitis, and 54.1% were prescribed antibiotics. Antibiotics were overprescribed for sore throats. Strategies are needed to promote rational antibiotic use.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142516555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico. 确定沙眼衣原体筛查和治疗对墨西哥母婴传播和新生儿呼吸道疾病结果的影响。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100843

Gabriel Arteaga-Troncoso, Marcela López-Hurtado, Gabino Yescas-Buendía, María J de Haro-Cruz, Iván Alejandro Arteaga-Martínez, Jesús Roberto Villagrana-Zesati, Fernando M Guerra-Infante

{"title":"Identifying the Impact of Chlamydia trachomatis Screening and Treatment on Mother-to-Child Transmission, and Respiratory Neonatal Outcomes in Mexico.","authors":"Gabriel Arteaga-Troncoso, Marcela López-Hurtado, Gabino Yescas-Buendía, María J de Haro-Cruz, Iván Alejandro Arteaga-Martínez, Jesús Roberto Villagrana-Zesati, Fernando M Guerra-Infante","doi":"10.3390/pathogens13100843","DOIUrl":"https://doi.org/10.3390/pathogens13100843","url":null,"abstract":"Chlamydia trachomatis (C. trachomatis) screening and treatment in pregnancy allows the opportunity to reduce adverse pregnancy and neonatal outcomes worldwide. Although C. trachomatis infection is easily treated and cured with antibiotics, only some countries have routine pregnancy screening and treatment programs. We therefore evaluated whether just one maternal screening for C. trachomatis is enough to prevent adverse pregnancy and negative neonatal outcomes. Among the 4087 first-time gynecological-obstetric consultations granted at the National Institute of Perinatology in 2018, we selected the study population according to a case-cohort design. Antenatal C. trachomatis screening and treatment interventions were performed on 628 pregnant women using COBAS® TaqMan CT. C. trachomatis DNA was also detected in samples from 157 infants of these mothers. In the maternal cohort, incidence of C. trachomatis infection was 10.5%. The vertical transmission rate was 1.5% for the cohort of mothers who tested positive for C. trachomatis and received treatment, and 29.7% for those with a negative test. By evaluating symptomatic neonatal infection, the hazard rate of perinatal pneumonia was 3.6 times higher in C. trachomatis-positive babies than in C. trachomatis-negative babies. Despite the low rate of mother-to-child transmission in women positive for C. trachomatis, possible maternal infection that is not detected in pregnancy significantly increases the risk of neonatal infection with consequent perinatal pneumonia.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Identification and Bioinformatics Analysis of Anaplasma marginale Moonlighting Proteins as Possible Antigenic Targets. 作为可能抗原靶标的边缘疟原虫月光蛋白的分子鉴定和生物信息学分析。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100845

Rosa Estela Quiroz-Castañeda, Hugo Aguilar-Díaz, Eduardo Coronado-Villanueva, Diego Israel Catalán-Ochoa, Itzel Amaro-Estrada

{"title":"Molecular Identification and Bioinformatics Analysis of Anaplasma marginale Moonlighting Proteins as Possible Antigenic Targets.","authors":"Rosa Estela Quiroz-Castañeda, Hugo Aguilar-Díaz, Eduardo Coronado-Villanueva, Diego Israel Catalán-Ochoa, Itzel Amaro-Estrada","doi":"10.3390/pathogens13100845","DOIUrl":"https://doi.org/10.3390/pathogens13100845","url":null,"abstract":"Background: Diseases of veterinary importance, such as bovine Anaplasmosis, cause significant economic losses. Due to this, the study of various proteins of the causal agent Anaplasma marginale has focused on surface proteins. However, a vaccine for this disease is not yet available. To this end, in this work, moonlighting proteins (MLPs) are presented as an alternative approach for the design of immunogens against A. marginale.Methods: The proteins of the strain MEX-15-099-01 were analyzed, and its MLPs were identified. Subsequently, four virulence-associated MLP genes were selected and identified using PCR. The proteins were analyzed using a structural homology approach and the collection of B-cell epitopes was predicted for each MLP. Finally, a pair of AmEno peptides were synthesized and the antigenic potential was tested using an iELISA.Results: Our bioinformatics analysis revealed the potential of AmEno, AmGroEl, AmEF-Tu, and AmDnaK proteins as promising candidates for designing immunogens. The PCR allowed the gene sequence identification in the genome of the strain MEX-15-099-01. Notably, AmEno-derived synthetic peptides showed antigenicity in an ELISA.Conclusions: Our study has shed light on the potential use of MLPs for immunogen design, demonstrating the antigenic potential of AmEno.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Characterization of a Clade 2.3.4.4b H5N1 High Pathogenicity Avian Influenza Virus from a 2022 Outbreak in Layer Chickens in the Philippines. 2022 年菲律宾蛋鸡疫情中 2.3.4.4b 支系 H5N1 高致病性禽流感病毒的分子特征。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-28 DOI: 10.3390/pathogens13100844

Zyne Baybay, Andrew Montecillo, Airish Pantua, Milagros Mananggit, Generoso Rene Romo, Esmeraldo San Pedro, Homer Pantua, Christina Lora Leyson

{"title":"Molecular Characterization of a Clade 2.3.4.4b H5N1 High Pathogenicity Avian Influenza Virus from a 2022 Outbreak in Layer Chickens in the Philippines.","authors":"Zyne Baybay, Andrew Montecillo, Airish Pantua, Milagros Mananggit, Generoso Rene Romo, Esmeraldo San Pedro, Homer Pantua, Christina Lora Leyson","doi":"10.3390/pathogens13100844","DOIUrl":"https://doi.org/10.3390/pathogens13100844","url":null,"abstract":"H5 subtype high-pathogenicity avian influenza (HPAI) viruses continue to devastate the poultry industry and threaten food security and public health. The first outbreak of H5 HPAI in the Philippines was reported in 2017. Since then, H5 HPAI outbreaks have been reported in 2020, 2022, and 2023. Here, we report the first publicly available complete whole-genome sequence of an H5N1 high-pathogenicity avian influenza virus from a case in Central Luzon. Samples were collected from a flock of layer chickens exhibiting signs of lethargy, droopy wings, and ecchymotic hemorrhages in trachea with excessive mucus exudates. A high mortality rate of 96-100% was observed within the week. Days prior to the high mortality event, migratory birds were observed around the chicken farm. Lungs, spleen, cloacal swabs, and oropharyngeal-tracheal swabs were taken from two chickens from this flock. These samples were positive in quantitative RT-PCR assays for influenza matrix and H5 hemagglutinin (HA) genes. To further characterize the virus, the same samples were subjected to whole-virus-genome amplification and sequencing using the Oxford Nanopore method with mean coverages of 19,190 and 2984, respectively. A phylogenetic analysis of the HA genes revealed that the H5N1 HPAI virus from Central Luzon belongs to the Goose/Guangdong lineage clade 2.3.4.4b viruses. Other segments also have high sequence identity and the same genetic lineages as other clade 2.3.4.4b viruses from Asia. Collectively, these data indicate that wild migratory birds are the likely source of H5N1 viruses from the 2022 outbreaks in the Philippines. Thus, biosecurity practices and surveillance for HPAI viruses in both domestic and wild birds should be increased to prevent and mitigate HPAI outbreaks.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Mechanisms of Drug Resistance in Leishmania spp. 利什曼原虫抗药性的分子机制

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-27 DOI: 10.3390/pathogens13100835

Maria Juliana Moncada-Diaz, Cristian Camilo Rodríguez-Almonacid, Eyson Quiceno-Giraldo, Francis T H Khuong, Carlos Muskus, Zemfira N Karamysheva

{"title":"Molecular Mechanisms of Drug Resistance in Leishmania spp.","authors":"Maria Juliana Moncada-Diaz, Cristian Camilo Rodríguez-Almonacid, Eyson Quiceno-Giraldo, Francis T H Khuong, Carlos Muskus, Zemfira N Karamysheva","doi":"10.3390/pathogens13100835","DOIUrl":"https://doi.org/10.3390/pathogens13100835","url":null,"abstract":"The protozoan parasite Leishmania causes leishmaniasis, a neglected tropical disease, that disproportionately affects underdeveloped countries. This disease has major health, economic, and social implications, particularly because of the limited treatment options, high cost, the severe side effects associated with available therapeutics, and the high rate of treatment failure caused by the parasites' growing resistance to current medications. In this review, we describe first the common strategies used by pathogens to develop drug resistance and then focus on the arsenal of available drugs to treat leishmaniasis, their modes of action, and the molecular mechanisms contributing to drug resistance in Leishmania spp., including the role of genomic, transcriptional, and translational control. We focus more specifically on our recent discovery of translational reprogramming as a major driver of drug resistance leading to coordinated changes in the translation of transcripts and orchestrating changes in metabolome and lipidome to support drug resistance. A thorough understanding of these mechanisms is essential to identify the key elements needed to combat resistance and improve leishmaniasis treatment methods.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Global to Nano: A Geographical Perspective of Aggregatibacter actinomycetemcomitans. 从全球到纳米：放线菌的地理视角。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-27 DOI: 10.3390/pathogens13100837

Mark I Ryder, Daniel H Fine, Annelise E Barron

{"title":"From Global to Nano: A Geographical Perspective of Aggregatibacter actinomycetemcomitans.","authors":"Mark I Ryder, Daniel H Fine, Annelise E Barron","doi":"10.3390/pathogens13100837","DOIUrl":"https://doi.org/10.3390/pathogens13100837","url":null,"abstract":"The periodontal disease pathobiont Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) may exert a range of detrimental effects on periodontal diseases in general and, more specifically, with the initiation and progression of Localized Stage III Grade C periodontitis (molar-incisor pattern). In this review of the biogeography of this pathobiont, the full range of geographical scales for A. actinomycetemcomitans, from global origins and transmission to local geographical regions, to more locally exposed probands and families, to the individual host, down to the oral cavity, and finally, to spatial interactions with other commensals and pathobionts within the plaque biofilms at the micron/nanoscale, are reviewed. Using the newest technologies in genetics, imaging, in vitro cultures, and other research disciplines, investigators may be able to gain new insights to the role of this pathobiont in the unique initial destructive patterns of Localized Stage III Grade C periodontitis. These findings may incorporate the unique features of the microbiome that are influenced by variations in the geographic environment within the entire mouth. Additional insights into the geographic distribution of molar-incisor periodontal breakdown for Localized Stage III Grade C periodontitis may derive from the spatial interactions between A. actinomycetemcomitans and other pathobionts such as Porphyromonas gingivalis, Filifactor aclocis, and commensals such as Streptococcus gordonii. In addition, while the association of A. actinomycetemcomitans in systemic diseases is limited at the present time, future studies into possible periodontal disease-systemic disease links may also find A. actinomycetemcomitans and its geographical interactions with other microbiome members to provide important clues as to implications of pathobiological communications.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Campylobacter coli Prosthetic Joint Infection: Case Report and a Review of the Literature. 大肠弯曲杆菌假关节感染：病例报告和文献综述。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-27 DOI: 10.3390/pathogens13100838

Stijn Jonckheere, Celestin Mairesse, Patricia Vandecandelaere, Jens Vanbiervliet, Wim Terryn, Jan Somers, Benoit Prevost, Delphine Martiny

引用次数: 0

Habitat Suitability of Ixodes ricinus Ticks Carrying Pathogens in North-East Italy. 意大利东北部携带病原体的蓖麻蜱的栖息地适宜性。

IF 3.3 3区医学

Pathogens Pub Date : 2024-09-27 DOI: 10.3390/pathogens13100836

Maartje Huitink, Myrna de Rooij, Fabrizio Montarsi, Maria Vittoria Salvati, Federica Obber, Graziana Da Rold, Sofia Sgubin, Elisa Mazzotta, Guido di Martino, Matteo Mazzucato, Cristiano Salata, Nicoletta Vonesch, Paola Tomao, Lapo Mughini-Gras

{"title":"Habitat Suitability of Ixodes ricinus Ticks Carrying Pathogens in North-East Italy.","authors":"Maartje Huitink, Myrna de Rooij, Fabrizio Montarsi, Maria Vittoria Salvati, Federica Obber, Graziana Da Rold, Sofia Sgubin, Elisa Mazzotta, Guido di Martino, Matteo Mazzucato, Cristiano Salata, Nicoletta Vonesch, Paola Tomao, Lapo Mughini-Gras","doi":"10.3390/pathogens13100836","DOIUrl":"https://doi.org/10.3390/pathogens13100836","url":null,"abstract":"Ixodes ricinus ticks are ubiquitous in Europe, including in North-East Italy. These ticks are important vectors of several zoonotic pathogens of public health relevance. In this study, the habitat suitability range of I. ricinus ticks infected with zoonotic pathogens was predicted in North-East Italy, and relevant spatial predictors were identified. In 2015-2021, ticks were collected at 26 sampling sites in the study area. The collected ticks were screened for the presence of pathogens using PCR assays. For Borrelia, Rickettsia and Anaplasma/Ehrlichia species, data allowed for ecological niche modelling using Maxent. Environmental determinants potentially related to tick habitat suitability were used as model inputs. Predicted suitable habitat distributions revealed hotspots of the probability of pathogen presence in I. ricinus ticks mainly in the central and upper parts of the study area. Key environmental predictors were temperature, rainfall and altitude, and vegetation index for specific pathogens (Rickettsia and Anaplasma/Ehrlichia species). Increased risk of exposure to tick-borne pathogens upon tick bites in the predicted hotspot areas can, therefore, be expected. This provides useful information for public health risk managers in this and other similar regions.","PeriodicalId":19758,"journal":{"name":"Pathogens","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0