Pain Medicine最新文献

{"title":"The effects of neuromodulation through brainwave entrainment on pain in women with fibromyalgia: a randomized controlled clinical trial with follow-up.","authors":"Gabriela de Souza, Luiza Daux Buffon, Rafaela Hardt da Silva, Taynah de Oliveira Galassi, Aline Raulino Dutra, Nayara Medeiros, Brenda Canatto de Paiva, Victor Juchem de Brito, Larice Nienkotter, Heloiza Dos Santos Baldança, Steffani Horstmann Goedert, Gislaine Tezza Rezin, Mariella Reinol da Silva, Mariana Pacheco de Oliveira, Fabricia Petronilho, Khiany Mathias, Anita Dal Bo Tiscoski, Leidiane Mazzardo-Martins, Eliane Silva de Azevedo Traebert, Anna Paula Piovezan, Jefferson L Traebert, Wolnei Caumo, Robert Schleip, Franciane Bobinski, Francisco J Cidral-Filho, Daniel F Martins","doi":"10.1093/pm/pnag064","DOIUrl":"10.1093/pm/pnag064","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia is a syndrome characterized by chronic, widespread pain. Its pathogenesis is not well-defined, but cumulative evidence indicates fibromyalgia is associated with alterations in brain surface wave frequencies.</p><p><strong>Objective: </strong>This study investigated the effects of brainwave entrainment (BWE) vs. music therapy for managing fibromyalgia in women.</p><p><strong>Methods: </strong>Eighty-four female patients with fibromyalgia were randomly assigned to 2 groups, namely music therapy (n = 42) or BWE administered using a BrainTap headset (n = 42). The music therapy and BWE groups were treated for 20 minutes daily, 5 times a week, over 8 weeks. Visual analog scale (VAS) for pain, McGill pain questionnaire (MPQ), fibromyalgia impact questionnaire (FIQ), and SF-36 quality of life questionnaire were applied at baseline, during the treatment, and post-intervention with a 6-month follow-up. Biochemical analyses and the Hamilton Depression and Anxiety Rating Scale (HAM-A and HAM-D) were performed at baseline and at the conclusion of the treatment.</p><p><strong>Results: </strong>BWE group reduced pain (P = .0001) as measured by the VAS and MPQ in the PRI total score and anxiety (P = .006). Furthermore, BWE improved parameters related to quality of life (BWE P = .002 vs MT P = .035), depression (BWE P = .0001 vs MT P = .006), and oxidative stress, and reduced BDNF (BWE P = .049 vs MT P = .030) levels in patients with fibromyalgia, an effect also observed with music therapy.</p><p><strong>Conclusions: </strong>BWE delivered through the BrainTap headset has the potential to alleviate pain and improve the quality of life in women with fibromyalgia. This effect appears to be related to oxidative stress and BDNF levels reduction.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"1040-1055"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of physical activity-based interventions to prevent or reduce chronic post-surgical pain.","authors":"Dennis Muñoz-Vergara, Jenna M Wilson, Alexandria E Cronin, Sarah Jaehwa Park, Yan Ma, Wren M Burton, EunMee Yang, Emma Dubinsky, Peter M Wayne, Kristin L Schreiber","doi":"10.1093/pm/pnag050","DOIUrl":"10.1093/pm/pnag050","url":null,"abstract":"<p><strong>Background: </strong>One potential risk after surgery is the development of chronic post-surgical pain (CPSP). Physical activity (PA) has emerged as a potential non-pharmacological approach for reducing the risk of CPSP. This systematic review synthesized and evaluated the current scientific evidence on the use of PA-based interventions for the prevention or reduction of CPSP.</p><p><strong>Methods: </strong>We conducted a systematic review of randomized controlled trials published from inception through October 2025. Inclusion criteria were surgical patients who completed a pain assessment ≥3 months post-surgery, comparing PA interventions with a control group. We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Synthesis Without Meta-Analysis guidelines, conducted a risk-of-bias assessment using the Cochrane risk-of-bias tool 2, and interpreted changes in CPSP relative to established minimal clinically important differences (MCIDs).</p><p><strong>Results: </strong>Thirteen studies (sample size mean: 86.5; median: 67; range: 20-194) met inclusion criteria, enrolling 1155 patients (67.8% female, 32.2% male) across four main surgery types (spine, total knee/hip arthroplasty, mastectomy, lung resection). Our descriptive synthesis found that PA programs were implemented predominantly post-surgically, and varied in terms of modality, duration, frequency, and session length. Control groups also differed, with only two studies describing active controls. Low-quality evidence supports that PA interventions significantly reduce CPSP compared to control, with two studies demonstrating pain reductions exceeding MCIDs thresholds. Only three studies were considered overall low risk of bias. Findings suggest that PA interventions may offer some benefit in reducing CPSP, although the evidence remains inconclusive.</p><p><strong>Conclusion: </strong>Evidence from available studies is insufficient to establish the definitive efficacy of PA in preventing or reducing CPSP. Future trials should clearly define intervention parameters and employ active control groups to strengthen methodological rigor. Incorporation of more comprehensive pain assessments will allow investigation of mechanisms of efficacy, as well as differential impact among patients.</p><p><strong>Prospero id: </strong>CRD42025626850.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"1004-1026"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can creatine help for pain? Creatine's potential role as an adjunctive treatment in pain management.","authors":"Kevin S Batti, Min Ju Kim, Joshua Lewis, Trent Emerick","doi":"10.1093/pm/pnag058","DOIUrl":"10.1093/pm/pnag058","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"1069-1071"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147777936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial moderators of response to a mindfulness-based stress reduction trial for chronic low back pain: considerations for intervention science and development.","authors":"Lorena S Nunes, Angela C Incollingo Rodriguez, Benjamin C Nephew, Richard B Lopez, Jean A King, Paula M Gardiner, Natalia E Morone","doi":"10.1093/pm/pnag046","DOIUrl":"10.1093/pm/pnag046","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"1079-1082"},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different types of exercise on pain thresholds in patients with chronic low back pain: a crossover randomized placebo-controlled clinical trial.","authors":"Rafael Escamilla-Ugarte, Pilar Alberola-Zorrilla, Daniel Sánchez-Zuriaga","doi":"10.1093/pm/pnag109","DOIUrl":"https://doi.org/10.1093/pm/pnag109","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply: \"AAPM Consensus Guidelines on Neuromodulation Technologies and Neurocomputer Interfaces for Pain Management and Functional Recovery\".","authors":"John E Rubin, Haipeng Zhang, Rohan Jotwani","doi":"10.1093/pm/pnag107","DOIUrl":"https://doi.org/10.1093/pm/pnag107","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting modeled economic value in AI-powered chronic pain self-management.","authors":"Kunlong Zhang, Xiaoqi Ying, Boxu Lang","doi":"10.1093/pm/pnag105","DOIUrl":"https://doi.org/10.1093/pm/pnag105","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Regarding \"American Academy of Pain Medicine Consensus Guidelines on Neuromodulation Technologies and Neurocomputer Interfaces for Pain Management and Functional Recovery\".","authors":"Trent Emerick, Kevin E Vorenkamp, Vinicius Tieppo Francio, Shriya Srinivasan, Priyanka Singla, Joel Castellanos, Farshad M Ahadian, Zheyan Chen, Anna Lepesteur Gianlorenco, Danielle Sarno, Nalini Sehgal, Nikhil Murthy, Antje M Barreveld","doi":"10.1093/pm/pnag106","DOIUrl":"10.1093/pm/pnag106","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descriptive studies should not be interpreted as economic evaluations.","authors":"Sara Olofsson, Maria L Rosen Klement, Antje M Barreveld, Neel Mehta, Ulf Persson, Carl A K Borrebaeck","doi":"10.1093/pm/pnag112","DOIUrl":"https://doi.org/10.1093/pm/pnag112","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations Regarding Comparator Selection and Long-Term Interpretation of Auricular Point Acupressure for Chronic Low Back Pain.","authors":"ZiHao Yi","doi":"10.1093/pm/pnag113","DOIUrl":"https://doi.org/10.1093/pm/pnag113","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}