Pain MedicinePub Date : 2024-07-01DOI: 10.1093/pm/pnae037
{"title":"Corrigendum to: Suicidal ideation in female individuals with fibromyalgia and comorbid obesity: prevalence and association with clinical, pain-related, and psychological factors.","authors":"","doi":"10.1093/pm/pnae037","DOIUrl":"10.1093/pm/pnae037","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11224576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140908616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-29DOI: 10.1093/pm/pnae057
Christopher Zarembinski, Robert Wright
{"title":"Lateral atlanto-axial joint access using the C2 pedicle.","authors":"Christopher Zarembinski, Robert Wright","doi":"10.1093/pm/pnae057","DOIUrl":"https://doi.org/10.1093/pm/pnae057","url":null,"abstract":"<p><strong>Background: </strong>Neck pain and headaches can arise from the lateral atlanto-axial joint (LAA joint). This pain can be diagnosed with intra-articular injections of local anesthetic. A widely used technique for access to the lateral atlanto-axial joint uses a posterior approach, but this approach can be hazardous because of the proximity of the vertebral artery, the dural sac, and the C2 spinal nerve and dorsal root ganglion.</p><p><strong>Objective: </strong>The objective was to describe and test a new technique for accessing the LAA joint that avoids structures that lie behind the joint.</p><p><strong>Interventions: </strong>The new technique was described, and tested for tolerance in 10 patients with unilateral suboccipital pain, and tenderness over the LAA joint, along with evidence of LAA joint arthropathy on SPECT CT. The technique requires inserting a needle along a trajectory tangential to the dorsal surface of the C2 lamina. It involves obtaining a declined view of the C2 lamina and C2 pedicle.</p><p><strong>Conclusions: </strong>In all cases, the C2 pedicle was easily identified and allowed the needle to pass asymptomatically underneath the neurovascular structures behind the joint. The tactile response of the lamina of C2 provided important feedback regarding needle depth caudal to the LAA joint.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-27DOI: 10.1093/pm/pnae054
Robert Burnham, Rory Trow, James Trow, Ashley Smith, Taylor Burnham
{"title":"Can ultrasound-guided medial branch blocks be used to select patients for cervical facet joint radiofrequency neurotomy? - A matched retrospective cohort validation study.","authors":"Robert Burnham, Rory Trow, James Trow, Ashley Smith, Taylor Burnham","doi":"10.1093/pm/pnae054","DOIUrl":"https://doi.org/10.1093/pm/pnae054","url":null,"abstract":"<p><strong>Background: </strong>Medial branch blocks are used to select patients for cervical facet joint radiofrequency neurotomy (CRFN). Blocks are typically performed under fluoroscopic guidance (FLB). The validity of ultrasound guided blocks (USB) is not well established. No prior research has compared cervical USB versus FLB validity using CRFN outcome as the criterion standard.</p><p><strong>Objective: </strong>To evaluate cervical USB versus FLB validity using CRFN outcome as the criterion standard.</p><p><strong>Methods: </strong>Demographic and outcome data were extracted from the EMRs of two affiliated MSK pain management clinics for all patients between 2015 and 2023 inclusive who had cervical USB leading to CRFN. CRFN outcomes of each USB patient were compared to a matched FLB patient from the RFN outcome database of the same clinics. Matching variables included patient age, sex, pain duration, diagnostics/prognostic block paradigm and CRFN number. Each patient completed a NRS pain score and Pain Disability Quality-of-Life Questionnaire (PDQQ) just before and 3-months post-CRFN. At repeat CRFN, patients provided a retrospective estimate of the duration and average magnitude (%) of relief following the CRFN.</p><p><strong>Results: </strong>USB and FLB groups were comprised of 27 patients (58 RFNs) and 38 patients (58 RFNs) respectively. Post RFN NRS pain severity and PDQQ-S scores demonstrated comparable (p > 0.05) absolute improvements, proportion of patients achieving ≥50% improvement, and attainment of MCID. Retrospective estimates of pain relief magnitude and duration were also comparable.</p><p><strong>Conclusions: </strong>This study finds cervical USB and FLB to be comparably valid as defined by their ability to predict CRFN outcome. Within the limitations of operator competence, USB can be used to select patients for CRFN.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-24DOI: 10.1093/pm/pnae052
Ka Ting Ng, Wei En Lim, Wan Yi Teoh, Mohd Fitry Bin Zainal Abidin
{"title":"Analgesic Effects of Intraperitoneal Lidocaine in Adults Undergoing Surgery: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.","authors":"Ka Ting Ng, Wei En Lim, Wan Yi Teoh, Mohd Fitry Bin Zainal Abidin","doi":"10.1093/pm/pnae052","DOIUrl":"https://doi.org/10.1093/pm/pnae052","url":null,"abstract":"<p><strong>Objective: </strong>The administration of local anaesthesia in intraperitoneal space as part of the multi-modal analgesic regimen has shown to be effective in reducing postoperative pain. Recent studies demonstrated that intraperitoneal lidocaine may provide analgesic effects. Primary objective was to determine the impact of intraperitoneal lidocaine on postoperative pain scores at rest.</p><p><strong>Design: </strong>We carried out a systematic review and meta-analysis according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).</p><p><strong>Methods: </strong>Databases of MEDLINE, EMBASE, and CENTRAL were searched from their inception date until May 2023. Randomized clinical trials (RCT) comparing intraperitoneal lidocaine and placebo in adults undergoing surgery were included.</p><p><strong>Results: </strong>Our systematic review included 24 RCTs (n = 1,824). The intraperitoneal lidocaine group was significantly associated with lower postoperative pain scores at rest (MD: -0.87, 95% CI: -1.04 to -0.69) and at movement (MD: -0.50, 95% Cl: -0.93 to -0.08) among adult patients after surgery. Its administration also significantly decreased morphine consumption (MD: -6.42 mg, 95% Cl: -11.56 to -1.27), lowered the incidence of needing analgesia (OR: 0.22, 95% Cl: 0.14 to 0.35). Intraperitoneal lidocaine statistically reduced time to resume regular diet (MD: 0.16 days; 95% Cl: -0.31 to -0.01), and lowered postoperative incidence of nausea and vomiting (OR: 0.54, 95% Cl: 0.39 to 0.75).</p><p><strong>Conclusions: </strong>In this review, our findings should be interpreted with caution. Future studies are warranted to determine the optimal dose of administering intraperitoneal lidocaine among adult patients undergoing surgery.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-20DOI: 10.1093/pm/pnae051
Patrick D Quinn, Olena Mazurenko, Richard Meraz, Zheng Chang, Toyya A Pujol, Adam T Hirsh, Arvid Sjölander, Kurt Kroenke, Brian M D'Onofrio
{"title":"Varying Definitions of Long-Term Opioid Therapy: Examining Prevalence, Prescription Patterns, and Substance-Related Adverse Outcomes.","authors":"Patrick D Quinn, Olena Mazurenko, Richard Meraz, Zheng Chang, Toyya A Pujol, Adam T Hirsh, Arvid Sjölander, Kurt Kroenke, Brian M D'Onofrio","doi":"10.1093/pm/pnae051","DOIUrl":"10.1093/pm/pnae051","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of fremanezumab treatment in patients with migraine headache.","authors":"Shoji Kikui, Danno Daisuke, Junichi Miyahara, Hanako Sugiyama, Kuniko Ota, Kenji Murakata, Yoshihiro Kashiwaya, Takao Takeshima","doi":"10.1093/pm/pnae050","DOIUrl":"https://doi.org/10.1093/pm/pnae050","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of fremanezumab for migraine prevention.</p><p><strong>Design: </strong>Retrospective, single-center, real-world study.</p><p><strong>Setting: </strong>Regional tertiary headache center in Japan.</p><p><strong>Subjects: </strong>Adult individuals with migraine (n = 165, male = 17, female = 148; average age = 45.5 ± 16.0 years) who received fremanezumab between September 2021 and August 2022.</p><p><strong>Methods: </strong>Fremanezumab was administered subcutaneously at a monthly dose of 225 mg or quarterly dose of 675 mg based on patient preferences. Patients received fremanezumab treatment for up to 1 year unless it was discontinued. Monthly data were collected on migraine days, headache days, and days requiring acute medication.</p><p><strong>Results: </strong>Of the 165 patients, 125 (75.7%) received fremanezumab as their first anti-calcitonin gene-related peptide-related antibody drug. Significant reductions in monthly migraine days, headache days, and days requiring acute medication were observed in those with episodic and chronic migraines. The baseline monthly headache days was 8.1 ± 4.0 in the episodic migraine group, which reduced to 6.1 ± 4.8, 5.8 ± 4.4, 4.7 ± 3.6, and 4.6 ± 3.3 days at 1, 3, 6, and 12 months, respectively; in the chronic migraine group, the baseline monthly headache days was 20.9 ± 6.1, which reduced to 17.0 ± 8.9, 15.0 ± 9.2, 13.0 ± 7.7, and 12.0 ± 9.1 days at 1, 3, 6, and 12 months, respectively. Treatment benefits were enhanced after 6 months of administering fremanezumab in the chronic migraine group.</p><p><strong>Conclusions: </strong>In this real-world study of patients with migraine, fremanezumab appears to be effective and safe. Further studies are required to identify additional predictors of treatment success and failure with fremanezumab.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-13DOI: 10.1093/pm/pnae044
David T McNaughton, Mark J Hancock, Madelyne A Bisby, Amelia J Scott, Michael P Jones, Blake F Dear
{"title":"The association between physical intervention use and treatment outcomes in patients participating in an online and psychologically informed pain management program.","authors":"David T McNaughton, Mark J Hancock, Madelyne A Bisby, Amelia J Scott, Michael P Jones, Blake F Dear","doi":"10.1093/pm/pnae044","DOIUrl":"https://doi.org/10.1093/pm/pnae044","url":null,"abstract":"<p><strong>Background: </strong>The availability of multidisciplinary care for the management of chronic pain is uncommon outside specialist clinics. The current study aims to determine the physical intervention use of patients participating in an online psychological pain management program and whether exposure to physical interventions in these patients alters treatment outcomes compared to patients who do not access physical interventions.</p><p><strong>Methods: </strong>Data were obtained from two previously published randomised control trials of an online psychological pain management program. Physical intervention exposure (category: None, 1-3, 4+ sessions) was assessed at baseline, post-treatment and at 3-month follow-up. Primary outcomes included depression, anxiety, pain intensity and pain-related disability. Generalised estimating equation models were used to compare treatment outcomes between those with different physical intervention frequencies and period of exposure. We assessed whether changes in primary outcomes differed (moderated) depending on the period and category of physical intervention exposure.</p><p><strong>Results: </strong>N = 1,074 patients completed the baseline questionnaire across both RCTs, of whom 470 (44%) reported physical intervention use at baseline, 383 (38%) at post-treatment and 363 (42%) at 3-month follow-up. On average, there were moderate-large reductions from baseline to post-treatment with respect to all outcomes (Cohen's d = 0.36-0.82). In all outcomes, the interaction of time by physical intervention exposure was statistically non-significant.</p><p><strong>Conclusion: </strong>A substantial proportion of patients who participated in a psychologically informed pain management program were establishing, continuing, or stopping additional physical interventions. The frequency and period of exposure to physical interventions did not appear moderate treatment outcomes.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-13DOI: 10.1093/pm/pnae049
Szilard Laszlo Safran, David Follonier, Eric Weber, Petra Vayne-Bossert, Ulrike Ahrendts, Benno Rehberg-Klug
{"title":"Cross-cultural adaptation and psychometric validation of the french version of the \"defense and veterans pain rating scale\" for acute and chronic pain: A prospective clinical study.","authors":"Szilard Laszlo Safran, David Follonier, Eric Weber, Petra Vayne-Bossert, Ulrike Ahrendts, Benno Rehberg-Klug","doi":"10.1093/pm/pnae049","DOIUrl":"https://doi.org/10.1093/pm/pnae049","url":null,"abstract":"<p><strong>Background: </strong>Pain assessment and proper evaluation of pain is a prerequisite for treatment of acute and chronic pain. Until now, most evaluations use only resting pain intensity and a unidimensional scale, although multidimensional pain assessment and especially assessment of functional pain impact on activities is recommended. The \"Defense and Veterans Pain Rating Scale\" (DVPRS) permits this multidimensional assessment, but no validated French translation exists.</p><p><strong>Objectives: </strong>To validate the French translation of the multidimensional DVPRS, called Functional Pain Scale (FPS) in multiple settings of acute and chronic pain.</p><p><strong>Study design: </strong>Prospective observational study.</p><p><strong>Setting: </strong>Two large hospitals in the French-speaking region of Switzerland.</p><p><strong>Methods: </strong>We recruited 232 patients from February 2022 to January 2023. Patients with acute or chronic pain in different settings received a paper questionnaire with both the NRS and the Functional Pain Scale and a customized evaluation questionnaire. Correlation of FPS and NRS, psychometric properties and patient preferences were analysed.</p><p><strong>Results: </strong>For the whole group of 232 patients, correlation of FPS and NRS was high, as well for all subgroups. The multi-item FPS scale showed excellent internal consistency. A large majority of patients, even those >75 years old, preferred FPS over NRS and stated that the FPS was easy to use.</p><p><strong>Conclusions: </strong>The study confirms that the French translation of the DVPRS (= Functional Pain Scale) is a valid measurement instrument for acute and chronic pain evaluation in a wide range of patient groups, and easy to use by patients.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-11DOI: 10.1093/pm/pnae048
Naz Y Alpdogan, Megan M Miller, Larbi Benallal, Marie-Pier Royer, Junie S Carrière
{"title":"Perceived injustice and pain-related outcomes in children with pain conditions: A systematic review.","authors":"Naz Y Alpdogan, Megan M Miller, Larbi Benallal, Marie-Pier Royer, Junie S Carrière","doi":"10.1093/pm/pnae048","DOIUrl":"https://doi.org/10.1093/pm/pnae048","url":null,"abstract":"<p><strong>Objective: </strong>Research indicates that perceived injustice significantly influences pain-related outcomes and is associated with delayed recovery in adults. This systematic review examines the relationship between perceived injustice and pain-related outcomes in children with pain conditions.</p><p><strong>Methods: </strong>A search of published studies in English in PubMed, PsychInfo and Cochrane Database of Systematic Reviews from database inception through December 2022 was performed. The search criteria focused on studies that measured perceived injustice and pain-related outcomes in children with pain conditions. Out of 56 articles screened, 8 met the inclusion criteria, providing data on 1240 children with pain conditions.</p><p><strong>Results: </strong>The average age of participants across all studies was 14.12 years (SD = 2.25), with 68.2% being female. There was strong evidence that higher perceived injustice is associated with worse pain intensity, functional disability, mental health outcomes, and emotional, social and school functioning.</p><p><strong>Conclusion: </strong>The results of this study underscore how perceptions of injustice are associated various pain-related outcomes across different domains of children's lives. The findings highlight the need for screening and treatments targeting injustice appraisals in pediatric populations with pain conditions. The discussion addresses possible determinants and mechanisms of perceived injustice, along with implications for research and clinical practice.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2024-06-06DOI: 10.1093/pm/pnae046
Tróndur Frídi Tróndarson, Filip Sandberg Storgaard, Mikkel Bjerre Larsen, Michael Skovdal Rathleff, Mikkel Bek Clausen, Kristian Damgaard Lyng
{"title":"Developing attributes and Attribute-Levels for subacromial pain syndrome: A systematic review and qualitative study.","authors":"Tróndur Frídi Tróndarson, Filip Sandberg Storgaard, Mikkel Bjerre Larsen, Michael Skovdal Rathleff, Mikkel Bek Clausen, Kristian Damgaard Lyng","doi":"10.1093/pm/pnae046","DOIUrl":"https://doi.org/10.1093/pm/pnae046","url":null,"abstract":"<p><strong>Background: </strong>Subacromial pain syndrome (SAPS), the most common cause of shoulder pain, can be treated through different treatments with similar effects. Therefore, in terms of deciding on the right treatment fit, patient preferences need to be understood. We aimed to identify treatment characteristics that delineate interventions (attributes) and corresponding sets of specific categorical range (attribute-levels) for SAPS.</p><p><strong>Methods: </strong>This multiple method study systematically reviewed both qualitative and quantitative studies on patient preferences for treatment of SAPS, which informed semi-structured interviews with nine clinicians and 14 patients. The qualitative data from the interviews was analyzed using the framework analysis formulated by Ritchie and Spencer. Attributes and attribute levels of the systematic review and interviews were summarized and categorized.</p><p><strong>Results: </strong>The search resulted in 2.607 studies, 16 of which met the eligibility criteria. The review identified 120 potential attributes, which were synthesized into 25 potential attributes. Fourteen new potential attributes were identified through the interviews, equaling a total of 39 attributes across 11 categories. Levels for 37 attributes were identified through systematic review and interviews, we were unable to identify levels for two attributes.</p><p><strong>Conclusions: </strong>This study identified attributes and attribute levels for the treatment of SAPS. There was a discrepancy in the frequency of the represented attributes between the literature and interviews. This study may improve the understanding of patient preferences for the treatment of SAPS and help individualize care. Our study informs a future discrete choice experiment and supports shared decision-making in clinical practice.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}