Pain MedicinePub Date : 2026-08-01DOI: 10.1093/pm/pnag032
Sebastian T Tong, Brennan Keiser, Karina Cortez, Elise Hoffman, Jin Wang, Kari A Stephens, Stacy Shaw Welch, Hazel Tapp, Caleb Holtzer, Kelly W Reeves, Sophia Jawort, Andrew T Humbert, Basia Belza, Thomas Ludden, Dennis C Ang, Kushang V Patel
{"title":"Integrated nurse care management to reduce pain interference for primary care patients in rural communities: results from a pilot study.","authors":"Sebastian T Tong, Brennan Keiser, Karina Cortez, Elise Hoffman, Jin Wang, Kari A Stephens, Stacy Shaw Welch, Hazel Tapp, Caleb Holtzer, Kelly W Reeves, Sophia Jawort, Andrew T Humbert, Basia Belza, Thomas Ludden, Dennis C Ang, Kushang V Patel","doi":"10.1093/pm/pnag032","DOIUrl":"10.1093/pm/pnag032","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"934-937"},"PeriodicalIF":4.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147308863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-08-01DOI: 10.1093/pm/pnag031
Priyanka Singla, James R Babington, Alexandra Adler, Fei Cao, Zheyan Chen, Jianguo Cheng, Timothy Furnish, Jennifer M Hah, Marie N Hanna, Tigran Kesayan, Philip Kim, Narayan R Kissoon, Zachary L McCormick, Kate Nicholson, Michael D Osborne, Nilesh Patel, Jeffrey D Petersohn, David A Provenzano, Joshua M Rosenow, Nathaniel M Schuster, Wahenoor Singh, Amol Soin, Antje M Barreveld
{"title":"CMS proposed restrictions on peripheral nerve blocks and procedures for chronic pain: clinical, ethical, and policy implications for millions of Americans.","authors":"Priyanka Singla, James R Babington, Alexandra Adler, Fei Cao, Zheyan Chen, Jianguo Cheng, Timothy Furnish, Jennifer M Hah, Marie N Hanna, Tigran Kesayan, Philip Kim, Narayan R Kissoon, Zachary L McCormick, Kate Nicholson, Michael D Osborne, Nilesh Patel, Jeffrey D Petersohn, David A Provenzano, Joshua M Rosenow, Nathaniel M Schuster, Wahenoor Singh, Amol Soin, Antje M Barreveld","doi":"10.1093/pm/pnag031","DOIUrl":"10.1093/pm/pnag031","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":"863-866"},"PeriodicalIF":4.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-07-25DOI: 10.1093/pm/pnag097
Maryam Kazemitabar, William C Becker, Steven B Zeliadt, Robert D Kerns, Jamie H Douglas, Erica A Abel, Haseena Rajeevan, Alicia A Heapy, Anne C Black
{"title":"Latent Patterns of Complementary and Integrative Health Therapy Utilization Among VHA Patients on Long-Term Opioid Therapy.","authors":"Maryam Kazemitabar, William C Becker, Steven B Zeliadt, Robert D Kerns, Jamie H Douglas, Erica A Abel, Haseena Rajeevan, Alicia A Heapy, Anne C Black","doi":"10.1093/pm/pnag097","DOIUrl":"https://doi.org/10.1093/pm/pnag097","url":null,"abstract":"<p><strong>Background: </strong>Complementary and integrative health (CIH) therapies offer safe and effective alternatives for pain management, and use of these therapies by Veteran Health Administration (VHA) patients with pain warrants examination.</p><p><strong>Objective: </strong>This study examines the patterns of CIH therapy utilization among VHA patients in a Long-Term Opioid Therapy (LTOT) cohort, identifying distinct subgroups of patients based on their CIH therapy use patterns and exploring how demographic and clinical characteristics are associated with membership in each subgroup.</p><p><strong>Methods: </strong>From a national retrospective cohort of VHA patients with a documented history of LTOT between 2017 and 2021, we analyzed electronic health record data of 17,079 VHA patients who used any CIH therapy during a 12-month period (October 2021 to September 2022). We assessed patterns of any use of nine CIH therapies through latent class regression analysis and assessed covariates of latent class membership.</p><p><strong>Results: </strong>A four-class solution was identified. The largest class was Chiropractic Care (32.3%), followed by Acupuncture (29.7%), Mind-Body therapies (28.0%), and Manual Therapy (10.0%). The chiropractic care class comprised those who utilized chiropractic care with some acupuncture co-use; Acupuncture class comprised patients using almost exclusively acupuncture; Mind-Body therapies class was defined by predominant use of meditation, yoga, and tai chi; and Manual Therapy class comprised patients who used massage, acupuncture, and chiropractic care. Significant demographic and clinical differences were observed between classes.</p><p><strong>Conclusion: </strong>These findings highlight distinct CIH therapy utilization patterns among VHA patients on LTOT associated with patients' demographic and clinical features. Quantifying patterns of CIH therapy use provides an effective framework for comparing pain and opioid-related outcomes across different groups. These findings suggest the need for investigating pathways to CIH that result in differences in use patterns.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-07-25DOI: 10.1093/pm/pnag096
Meredith Barad, Trent Emerick, Lynn Kohan, Alexander Bautista, Yashar Eshraghi, Prentiss Lawson, Kristen Noon, Christine Oryhan, Tolga Suvar
{"title":"Don't Just Fill to Fill: Thoughts on the 2026 Match from the Association of Pain Program Directors.","authors":"Meredith Barad, Trent Emerick, Lynn Kohan, Alexander Bautista, Yashar Eshraghi, Prentiss Lawson, Kristen Noon, Christine Oryhan, Tolga Suvar","doi":"10.1093/pm/pnag096","DOIUrl":"https://doi.org/10.1093/pm/pnag096","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-07-25DOI: 10.1093/pm/pnag095
Todd Mitchell Bertoch, Seth Grisham, Susanne Vogt, Scott Haughie, Kathleen Ocasio, Jeffrey P Smith
{"title":"A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Response Study of MR-107A-02 in the Treatment of Post-Surgical Dental Pain.","authors":"Todd Mitchell Bertoch, Seth Grisham, Susanne Vogt, Scott Haughie, Kathleen Ocasio, Jeffrey P Smith","doi":"10.1093/pm/pnag095","DOIUrl":"https://doi.org/10.1093/pm/pnag095","url":null,"abstract":"<p><strong>Background: </strong>MR-107A-02 is a novel, oral meloxicam formulation designed to enhance dissolution and absorption for rapid analgesia in acute pain. It demonstrates a favorable pharmacokinetic profile, with a higher Cmax and shorter Tmax than Mobic® (meloxicam tablets), while maintaining similar overall extent of exposure.</p><p><strong>Methods: </strong>This phase 2b, randomized, double-blind, placebo-controlled, dose-ranging study assessed the efficacy and safety of MR-107A-02 at doses of 1.25, 5, and 15 mg twice daily (BID) following third molar extraction. The primary endpoint was SPID0-24, analyzed in the mITT population using W6LOCF to account for rescue medication use. Pain intensity and categorical ratings were evaluated using standardized pain scales. Onset of perceptible and meaningful pain relief were measured using the double-stopwatch technique. Effect sizes and associated standard errors, p-values, and 95% CIs were estimated using an Emax model.</p><p><strong>Results: </strong>Among 110 participants, MR-107A-02 demonstrated positive dose-dependent analgesia, with mean SPID0-24 Emax values of 70.7 (1.25 mg), 86.7 (5 mg), and 94.8 (15 mg), versus 52.0 for placebo. Significant improvement in SPID0-24 occurred at 5 mg and 15 mg versus placebo (p < 0.001). The 15 mg dose achieved perceptible and meaningful pain relief within 0.6 and 1.5 hours, respectively, and had the lowest rescue medication use (29.6%) compared to 42.9%, 57.1%, and 74.1% in the 1.25 mg, 5 mg, and placebo. No severe TEAEs, SAEs, or discontinuations were reported.</p><p><strong>Conclusions: </strong>MR-107A-02 was generally well tolerated and demonstrated dose-dependent efficacy, with the 15 mg BID dose providing rapid analgesia and a reduction in rescue medication use.</p>","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-07-24DOI: 10.1093/pm/pnag094
Laura Kennelly, Theodoros Mavridis, Yerko Ivanovic-Barbeito
{"title":"Post-traumatic Great Auricular Neuralgia Presenting as Retro-auricular Pain: An Under-recognised Cause of Craniofacial Neuralgia.","authors":"Laura Kennelly, Theodoros Mavridis, Yerko Ivanovic-Barbeito","doi":"10.1093/pm/pnag094","DOIUrl":"https://doi.org/10.1093/pm/pnag094","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain MedicinePub Date : 2026-07-17DOI: 10.1093/pm/pnag086
{"title":"Erratum to: The Current Role of Ultrasound Use in Teaching Regional Anesthesia: A Survey of Residency Programs in the United States.","authors":"","doi":"10.1093/pm/pnag086","DOIUrl":"https://doi.org/10.1093/pm/pnag086","url":null,"abstract":"","PeriodicalId":19744,"journal":{"name":"Pain Medicine","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}