Otology & Neurotology最新文献

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Diagnosis and Treatment of Middle Ear Cholesterol Granuloma Involving the Middle Cranial fossa. 累及中颅窝的中耳胆固醇肉芽肿的诊断与治疗。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1097/MAO.0000000000004551
Shengqing Nian, Chenyu Chen, Yuqing Chen, Xihang Chen, Chang Lin
{"title":"Diagnosis and Treatment of Middle Ear Cholesterol Granuloma Involving the Middle Cranial fossa.","authors":"Shengqing Nian, Chenyu Chen, Yuqing Chen, Xihang Chen, Chang Lin","doi":"10.1097/MAO.0000000000004551","DOIUrl":"10.1097/MAO.0000000000004551","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical features, surgical options, and prognosis of middle ear cholesterol granuloma involving the middle cranial fossa.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Subjects and methods: </strong>Medical records of three patients with giant skull base cholesterol granuloma from 2006 to 2017 were retrospectively analyzed. The symptoms, signs, radiological features, treatment options, and prognosis were summarized.</p><p><strong>Results: </strong>All patients underwent radical mastoidectomy and resection of skull base lesions by means of a retroauricular approach. Postoperative pathological diagnosis showed cholesterol granuloma. All patients were followed for more than 1 year. The symptoms were relieved, and there was no recurrence. Postoperative imaging showed that the skull base lesions were cleared and the compressed brain tissue recovered.</p><p><strong>Conclusion: </strong>Patients with middle ear cholesterol granuloma involving the middle cranial fossa can be operated on by retroauricular approach. It can reduce the trauma of craniotomy and obtain good curative effect.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e419-e422"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Cortical Auditory Evoked Potentials in Active Middle Ear and Bone Conduction Implant Users: An Objective Method to Optimize the Fitting. 利用活跃中耳和骨传导植入体使用者的皮质听觉诱发电位:一种优化配合的客观方法。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1097/MAO.0000000000004581
Marcus Voola, Lorenzo Vignali, Hamidreza Mojallal, Caris Bogdanov, Dayse Távora-Vieira
{"title":"Using Cortical Auditory Evoked Potentials in Active Middle Ear and Bone Conduction Implant Users: An Objective Method to Optimize the Fitting.","authors":"Marcus Voola, Lorenzo Vignali, Hamidreza Mojallal, Caris Bogdanov, Dayse Távora-Vieira","doi":"10.1097/MAO.0000000000004581","DOIUrl":"10.1097/MAO.0000000000004581","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to investigate whether cortical auditory evoked potential (CAEP) measures could be used to optimize active middle ear implant (aMEI) and bone conduction implant (BCI) fitting, with the goal of improving hearing outcomes in adults.</p><p><strong>Design: </strong>CAEPs were measured in response to LING sounds /OO/, /AH/, and /SH/ presented in sound field. If CAEP responses were recorded for all sounds, no map adjustments were performed. If a CAEP response was absent for one or more sounds, map parameters were optimized until a CAEP response could be induced. Functional outcomes were measured as pre- vs postoptimization adaptive speech-in-noise results. Subjective feedback was also collected.</p><p><strong>Results: </strong>Of the 15 participants, one was excluded from the study, three did not need optimization, nine were successfully optimized using CAEP measurements, and two could not be optimized. Comparison of CAEP morphology showed significant differences pre- vs postoptimization for middle- and high-frequency sounds (i.e., /AH/ and /SH/). Speech-in-noise testing revealed significant improvements pre- vs postoptimization, and participants were generally satisfied with the overall procedure.</p><p><strong>Conclusion: </strong>These findings demonstrated that middle- and high-frequency tokens could be successfully optimized using CAEPs, resulting in significant improvements in hearing performance. Our results support the use of CAEPs for the optimization of aMEI and BCI adult users' fitting.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"1037-1044"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photon-Counting CT Reveals Radiologically Occult Otospongiosis: A Case Report. 光子计数CT显示隐匿性耳海绵症1例。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-07-11 DOI: 10.1097/MAO.0000000000004599
Anna Dordonnat, Neil Grislain, Gabriel Garcia, Jean-Noël Vallée, Michael Eliezer
{"title":"Photon-Counting CT Reveals Radiologically Occult Otospongiosis: A Case Report.","authors":"Anna Dordonnat, Neil Grislain, Gabriel Garcia, Jean-Noël Vallée, Michael Eliezer","doi":"10.1097/MAO.0000000000004599","DOIUrl":"10.1097/MAO.0000000000004599","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e447-e448"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear. 一种新型经鼻导管经内耳低温输送的研制与评价。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-07-17 DOI: 10.1097/MAO.0000000000004596
Pavan S Krishnan, Maria Fernanda Yepes, Curtis S King, Suhrud M Rajguru
{"title":"Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear.","authors":"Pavan S Krishnan, Maria Fernanda Yepes, Curtis S King, Suhrud M Rajguru","doi":"10.1097/MAO.0000000000004596","DOIUrl":"10.1097/MAO.0000000000004596","url":null,"abstract":"<p><strong>Abstract: </strong>Mild therapeutic hypothermia (MTH) has demonstrated neuroprotective effects in the cochlea, particularly against noise-induced and electrode insertion trauma, by reducing inflammation and oxidative stress. Prior cadaveric studies have shown that localized cochlear cooling can be achieved using a probe placed on the promontory or a surface cooling device placed on the mastoid. While the effects of MTH on the vestibular system remain unstudied, its proximity and physiological similarity to the cochlea suggest potential benefits. We aimed to develop the first noninvasive, localized MTH device for use in the clinical environment, capable of targeting both cochlear and vestibular structures without obstructing the surgical field. A custom-designed, saline-filled cooling catheter with a balloon tip was designed to be positioned in the ear canal adjacent to the tympanic membrane. Temperature measurements were recorded from the round window, oval window, and all three semicircular canals, and compared to whole-head temperature fluctuations measured via the nasopharynx in human cadaver samples. Thermistors recorded an average temperature reduction of 4-6°C during a 30-minute protocol in cadaver heads. Nasopharyngeal temperature remained stable throughout. Furthermore, a numerical model was used to evaluate the theoretical temperature reduction achieved through ear canal cooling. The computational model further validated the experimental measurements from the cochlea. In conclusion, these findings demonstrate that cochlear and vestibular hypothermia can be effectively induced using an external cooling system positioned in the ear canal, supporting the development of a more accessible and practical clinical approach to protect the inner ear during invasive procedures.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"1171-1177"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facial Nerve Management and Hearing Preservation and Rehabilitation in Petrous Bone Cholesteatoma (PBC). 石质骨胆脂瘤(PBC)的面神经管理与听力保护与康复。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-08-04 DOI: 10.1097/MAO.0000000000004592
Monica Rueda Vega, M Montserrat Asensi Diaz, Carlos Martín Oviedo, Ignacio Arístegui Torrano, Miguel Arístegui Ruiz
{"title":"Facial Nerve Management and Hearing Preservation and Rehabilitation in Petrous Bone Cholesteatoma (PBC).","authors":"Monica Rueda Vega, M Montserrat Asensi Diaz, Carlos Martín Oviedo, Ignacio Arístegui Torrano, Miguel Arístegui Ruiz","doi":"10.1097/MAO.0000000000004592","DOIUrl":"10.1097/MAO.0000000000004592","url":null,"abstract":"<p><strong>Objective: </strong>To assess our experience in the management of the facial nerve and hearing rehabilitation in patients with petrous bone cholesteatoma (PBC).</p><p><strong>Study design: </strong>Retrospective case review.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>PBC cases managed by the senior authors between 1995 and 2024.</p><p><strong>Main outcome measures: </strong>Clinical presentation, Sanna's classification, presurgical and postsurgical audiometry and facial function, surgical approach (including assisted endoscopic techniques), recurrence rates, intraoperative findings and facial nerve management, hearing rehabilitation, facial nerve repair techniques.</p><p><strong>Results: </strong>Ninety-two cases were reported. The most common type was supralabyrinthine PBCs (40.43%). Hearing loss was present in almost all the patients (98.91%), with moderate mixed hearing loss (35.87%) being the most frequent preoperative audiometric finding. Hearing rehabilitation was performed in 11 patients (8 cochlear implants, 3 bone conduction implants). Postoperative normal function was achieved in 49 cases (53.26%). Intraoperatively, the facial nerve was interrupted in eight cases (13.3%). In five cases, a facial-hypoglossal nerve anastomosis was performed. Facial palsy was statistically more frequent in massive and supralabyrinthine PBCs ( p = 0.048). There is a statistically significant relation between preoperative and postoperative facial function and facial nerve intraoperative findings ( p = 0.001 and p = 0.000, respectively).</p><p><strong>Conclusions: </strong>Advances in surgical techniques and early diagnosis have improved facial nerve preservation. However, surgical repair remains essential for patients with significant preoperative facial nerve involvement. On the other hand, although the primary focus in PBC surgery is complete disease removal and preservation of facial nerve function, the opportunity to rehabilitate hearing should not be overlooked.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"1150-1157"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of MRI Cochlear FLAIR Signal on Hearing Preservation after Middle Fossa Vestibular Schwannoma Resection. MRI耳蜗FLAIR信号对中窝前庭神经鞘瘤切除术后听力保存的影响。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1097/MAO.0000000000004619
Nicole Ewer, Samira Takkoush, Jason L Steele, Heather J Smith, Melissa Shuhui Lee, Mana Espahbodi, Richard H Wiggins, William T Couldwell, Richard K Gurgel, Neil S Patel
{"title":"Impact of MRI Cochlear FLAIR Signal on Hearing Preservation after Middle Fossa Vestibular Schwannoma Resection.","authors":"Nicole Ewer, Samira Takkoush, Jason L Steele, Heather J Smith, Melissa Shuhui Lee, Mana Espahbodi, Richard H Wiggins, William T Couldwell, Richard K Gurgel, Neil S Patel","doi":"10.1097/MAO.0000000000004619","DOIUrl":"10.1097/MAO.0000000000004619","url":null,"abstract":"<p><strong>Objective: </strong>Literature is limited regarding the relationship between cochlear magnetic resonance imaging fluid-attenuated inversion recovery (FLAIR) signal and hearing preservation after resection of vestibular schwannoma (VS). We hypothesize that increased preoperative FLAIR signal is associated with decreased odds of hearing preservation.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Single academic tertiary/quaternary care center.</p><p><strong>Patients: </strong>Subjects with histologically confirmed intracanalicular VS (without extension into the cerebellopontine angle).</p><p><strong>Intervention: </strong>Microsurgical resection via middle fossa approach.</p><p><strong>Main outcome measures: </strong>A review of demographic, clinical, radiographic, and audiometric outcomes were performed. Hearing preservation was defined as American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) class A or B hearing. Binary logistic regression analysis was performed with SPSS version 29.</p><p><strong>Results: </strong>Twenty-seven subjects met inclusion criteria with median age at time of surgery of 47 (interquartile range [IQR]: 38-54) years; 92.60% were White; 66.67% had AAO-HNS class A, and 33.33% had class B hearing. Postoperatively, at median (IQR) of 11.50 (2.10-38.50) months, 44.40% had class A or B hearing. On logistic regression analysis, a ratio of cochlea-to-brainstem FLAIR signal greater than 0.6 was associated with decreased odds of hearing preservation at 11.50 months-odds ratio, 0.13; 95% confidence interval, 0.02-0.84. Age, sex, surgery duration, tumor volume and linear dimension, fundal cap of cerebrospinal fluid, and extent of resection were not associated with hearing preservation.</p><p><strong>Conclusion: </strong>Increased cochlear FLAIR signal on preoperative imaging is associated with decreased likelihood of hearing preservation after resection of intracanalicular, sporadic VS via middle fossa approach.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e428-e433"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Factors for Facial Nerve Outcome after Vestibular Schwannoma Surgery: A 12-Year Multicentric Retrospective Study. 前庭神经鞘瘤手术后面神经预后的预后因素:一项12年多中心回顾性研究。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-09-01 Epub Date: 2025-06-09 DOI: 10.1097/MAO.0000000000004582
Daniela Lucidi, Daniele Marchioni, Nicola Bisi, Federico Calvaruso, Livio Presutti, Matteo Alicandri-Ciufelli, Sara Donvito
{"title":"Prognostic Factors for Facial Nerve Outcome after Vestibular Schwannoma Surgery: A 12-Year Multicentric Retrospective Study.","authors":"Daniela Lucidi, Daniele Marchioni, Nicola Bisi, Federico Calvaruso, Livio Presutti, Matteo Alicandri-Ciufelli, Sara Donvito","doi":"10.1097/MAO.0000000000004582","DOIUrl":"10.1097/MAO.0000000000004582","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate facial nerve (FN) impairment in patients undergoing three vestibular schwannoma (VS) surgical techniques and identify variables influencing FN function.</p><p><strong>Materials and methods: </strong>A retrospective multicentric analysis was conducted on patients treated between 2010 and 2022 using retrosigmoid (RS), translabyrinthine (TL), or transcanal transpromontorial surgery (TTS). All participants had normal preoperative FN function and no previous radiotherapy. FN function was evaluated immediately, 6, 12, and 24 months post-surgery using the HB scale.</p><p><strong>Results: </strong>Among 234 patients, the median FN grade was HB III immediately post-surgery, improving to HB II at 6, 12, and 24 months. Transient FN palsy occurred in 48%, whereas permanent palsy affected 39%. Higher Koos grades were significantly associated with worse FN outcomes. Older age correlated with poorer recovery at 6, 12, and 24 months ( p = 0.03, 0.009, 0.02). In Koos II cases, TL yielded better FN function than RS at 48 hours and 12 months ( p = 0.03). Among Koos III patients, FN preservation rates were significantly higher with TL versus RS at all time points ( p = 0.003, 0.003, 0.001, 0.004). TTS demonstrated superior FN preservation compared with RS at 12 and 24 months ( p = 0.007, 0.001). Multivariate analysis revealed younger age, lower Koos, TL, and TTS as predictors of better FN outcomes.</p><p><strong>Discussion: </strong>Younger age, lower Koos grades, and the TL and TTS approaches are significantly linked to improved FN function after VS surgery.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"978-983"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Expression Quantitative Trait Loci and Genome-Wide Association Study Identifies Druggable Genes for Tinnitus. 整合表达、数量性状位点和全基因组关联研究鉴定耳鸣可用药基因。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-09-01 Epub Date: 2025-06-06 DOI: 10.1097/MAO.0000000000004574
Tao Guo, Jingqi Zhang, Xianpeng Xu, Dehong Liu, Guobing Jia, Xinghong Liu, Hui Xie
{"title":"Integrating Expression Quantitative Trait Loci and Genome-Wide Association Study Identifies Druggable Genes for Tinnitus.","authors":"Tao Guo, Jingqi Zhang, Xianpeng Xu, Dehong Liu, Guobing Jia, Xinghong Liu, Hui Xie","doi":"10.1097/MAO.0000000000004574","DOIUrl":"10.1097/MAO.0000000000004574","url":null,"abstract":"<p><strong>Background: </strong>The investigation of druggable target genes through large-scale expression quantitative trait loci (eQTL) and genome-wide association study (GWAS) data has demonstrated promise across various diseases. This approach has yet to be explored in the context of tinnitus.</p><p><strong>Methods: </strong>We obtained cis-eQTL data for 3,453 druggable genes from eQTLGen. Tinnitus phenotype derived from the UK Biobank was used as the discovery cohort. A large-scale Mendelian randomization (MR) analysis was conducted to investigate the inferred causal relationships between the 3,453 druggable genes and tinnitus. Replication analyses were conducted using tinnitus phenotypes from FinnGen. We further conducted colocalization analysis to identify actionable drug targets for tinnitus. Besides, MR analysis was used to explore the association of the identified genes with hearing loss and inflammation.</p><p><strong>Results: </strong>Genetic predictions indicated that the expression of NEU1 (β = 0.137, 95% CI = 0.112 to 0.162, p = 2.21 × 10 -26 ), APOM (β = 0.139, 95% CI = 0.112 to 0.166, p = 1.23 × 10 -24 ), and TUBB (β = -0.043, 95% CI = -0.062 to -0.024, p = 5.46 × 10 -6 ) was causally associated with tinnitus. Our replication analysis in FinnGen yielded consistent results. There is a strong colocalization association between the three genes and tinnitus (PPH4 > 0.8). No evidence indicated these three genes were associated with hearing loss. Network MR suggested that IL-17C and CCL20 mediates effects of APOM on tinnitus, and IL-17C accounts for effects of NEU1 on tinnitus.</p><p><strong>Conclusions: </strong>Our findings investigated the potential pathological mechanisms and therapeutic targets of tinnitus, providing novel strategies for future clinical trials.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e349-e358"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Audiological Progression and Treatment Outcomes in Superficial Siderosis: A 10-Year Retrospective Review of 46 Patients. 浅表性铁沉着的听力学进展和治疗结果:对46例患者的10年回顾性分析。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-09-01 Epub Date: 2025-06-13 DOI: 10.1097/MAO.0000000000004535
Ayako Nishio, Yoshiyuki Kawashima, Takamori Takeda, Taku Ito, Ayako Maruyama, Yoshimaru Mizoguchi, Natsuko Kurata, Ryo Iwase, Satoru Egawa, Takashi Hirai, Motonori Hashimoto, Takanori Yokota, Toshitaka Yoshii, Nobuo Sanjo, Takeshi Tsutsumi
{"title":"Audiological Progression and Treatment Outcomes in Superficial Siderosis: A 10-Year Retrospective Review of 46 Patients.","authors":"Ayako Nishio, Yoshiyuki Kawashima, Takamori Takeda, Taku Ito, Ayako Maruyama, Yoshimaru Mizoguchi, Natsuko Kurata, Ryo Iwase, Satoru Egawa, Takashi Hirai, Motonori Hashimoto, Takanori Yokota, Toshitaka Yoshii, Nobuo Sanjo, Takeshi Tsutsumi","doi":"10.1097/MAO.0000000000004535","DOIUrl":"10.1097/MAO.0000000000004535","url":null,"abstract":"<p><strong>Objective: </strong>To describe long-term hearing outcomes and evaluate the efficacy of interventions in patients with superficial siderosis (SS) of the central nervous system (CNS).</p><p><strong>Study design: </strong>Retrospective case review.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Forty-six patients diagnosed with SS.</p><p><strong>Interventions: </strong>Auditory examinations, including pure-tone audiometry, speech audiometry, and auditory brainstem response (ABR). Treatment modalities include surgical closure of the dural defect with postoperative iron chelator administration and cochlear implantation.</p><p><strong>Main outcome measures: </strong>Pure-tone average (PTA), maximum speech discrimination score, and interpeak latency between ABR waves I and V.</p><p><strong>Results: </strong>Sensorineural hearing loss (SNHL) was observed in 39 patients (84.8%), typically presenting in the fifth to sixth decades of life, and progressed gradually. Among the patients, SNHL was bilateral in 76.9%, with 56.7% showing asymmetry. The severity ranged from minimal to profound, with high-frequency loss being the most common (63.8%). Abnormal ABRs were observed in 82.6% of the ears. Long-term follow-up (median, 39 months) revealed hearing deterioration of ≥10 dB PTA in 25.9% of the ears. The long-term hearing prognosis can be predicted based on audiological changes within the first 12 months after the initial visit. Dural defect closure with iron chelator treatment seemed to prevent hearing deterioration in seven patients. Cochlear implantation showed limited effectiveness in three patients.</p><p><strong>Conclusions: </strong>SS-related hearing loss can mimic age-related hearing loss, potentially leading to misdiagnoses. Clinicians should consider SS in middle-aged to elderly patients with progressive SNHL of unknown etiology and conduct comprehensive examinations, including speech audiometry, ABR, and T2*-weighted MRI, to facilitate an early diagnosis and appropriate management.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"895-902"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic Review of the Impact of Magnetic Resonance Imaging on Diametric Magnet Cochlear Implants. 磁共振成像对直径磁铁人工耳蜗影响的系统综述。
IF 2 3区 医学
Otology & Neurotology Pub Date : 2025-09-01 Epub Date: 2025-06-03 DOI: 10.1097/MAO.0000000000004556
Quan Lu, Sidney Spencer, Anita Jeyakumar
{"title":"Systematic Review of the Impact of Magnetic Resonance Imaging on Diametric Magnet Cochlear Implants.","authors":"Quan Lu, Sidney Spencer, Anita Jeyakumar","doi":"10.1097/MAO.0000000000004556","DOIUrl":"10.1097/MAO.0000000000004556","url":null,"abstract":"<p><strong>Objective: </strong>Review the properties, safety, and artifacts of current cochlear implants (CI) with freely rotatable magnets during MRI scans.</p><p><strong>Databases reviewed: </strong>PubMed, Cochrane, and Web of Science; last accessed September 2023.</p><p><strong>Methods: </strong>The study was BSMH IRB exempted. MESH term \"magnetic resonance imaging\" and phrases of \"Med-el Synchrony,\" \"Cochlear Nucleus Profile Plus,\" \"Advanced Bionics HiRes Ultra 3D,\" \"rotatable magnet cochlear,\" \"rotatable magnet,\" \"diametric magnet,\" \"diametric magnet cochlear implant,\" and \"MRI-safe cochlear implant\" using \"AND\" function. Non-English, non-human, non-implanted CI, and cadaveric studies were excluded. Methodological quality was assessed using the Mixed Methods Appraisal Tool, and quality of the evidence was evaluated using the GRADE criteria.</p><p><strong>Results: </strong>The review included 18 studies. Fifteen assessed pain as a complication, with two reporting its occurrence: two cases for Synchrony and one for Ultra 3D. Demagnetization did not occur in the 12 studies that reported on it. One magnet displacement was noted with the Ultra 3D implant out of the 16 reporting studies. Artifacts were reported by 11 studies, with most scans retaining most to limited diagnostic usability. One Synchrony device required explantation due to artifact, and one was explanted before MRI.</p><p><strong>Conclusion: </strong>Of the CI models reviewed with diametric magnets, Med-El Synchrony may enable MRI usage with fewer safety concerns when following the manufacturer's recommendations. However, clinical reports of freely rotatable CI safety during MRI scans are sparse and contain incomplete data. MRI artifacts from CI still pose concerns for image quality but can be minimized with appropriate implant location and scanning protocols.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"918-923"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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