Otology & Neurotology最新文献

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Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear. 一种新型经鼻导管经内耳低温输送的研制与评价。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-17 DOI: 10.1097/MAO.0000000000004596
Pavan S Krishnan, Maria Fernanda Yepes, Curtis S King, Suhrud M Rajguru
{"title":"Development and Evaluation of a Novel Transcanal Catheter for Delivery of Hypothermia to the Inner Ear.","authors":"Pavan S Krishnan, Maria Fernanda Yepes, Curtis S King, Suhrud M Rajguru","doi":"10.1097/MAO.0000000000004596","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004596","url":null,"abstract":"<p><strong>Abstract: </strong>Mild therapeutic hypothermia (MTH) has demonstrated neuroprotective effects in the cochlea, particularly against noise-induced and electrode insertion trauma, by reducing inflammation and oxidative stress. Prior cadaveric studies have shown that localized cochlear cooling can be achieved using a probe placed on the promontory or a surface cooling device placed on the mastoid. While the effects of MTH on the vestibular system remain unstudied, its proximity and physiological similarity to the cochlea suggest potential benefits. We aimed to develop the first noninvasive, localized MTH device for use in the clinical environment, capable of targeting both cochlear and vestibular structures without obstructing the surgical field. A custom-designed, saline-filled cooling catheter with a balloon tip was designed to be positioned in the ear canal adjacent to the tympanic membrane. Temperature measurements were recorded from the round window, oval window, and all three semicircular canals, and compared to whole-head temperature fluctuations measured via the nasopharynx in human cadaver samples. Thermistors recorded an average temperature reduction of 4-6°C during a 30-minute protocol in cadaver heads. Nasopharyngeal temperature remained stable throughout. Furthermore, a numerical model was used to evaluate the theoretical temperature reduction achieved through ear canal cooling. The computational model further validated the experimental measurements from the cochlea. In conclusion, these findings demonstrate that cochlear and vestibular hypothermia can be effectively induced using an external cooling system positioned in the ear canal, supporting the development of a more accessible and practical clinical approach to protect the inner ear during invasive procedures.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Sided Deafness and Cochlear Implants: Performance in a Novel Combined Speech-in-Noise and Localization Task. 单侧耳聋和人工耳蜗植入:在一种新的结合语音噪声和定位任务中的表现。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-16 DOI: 10.1097/MAO.0000000000004537
Nadine I Ibrahim, Obada Abdulrazzak, Chioma Anidi, Gerilyn Jones, Madison V Epperson, Anahita H Mehta, Renee M Banakis Hartl
{"title":"Single-Sided Deafness and Cochlear Implants: Performance in a Novel Combined Speech-in-Noise and Localization Task.","authors":"Nadine I Ibrahim, Obada Abdulrazzak, Chioma Anidi, Gerilyn Jones, Madison V Epperson, Anahita H Mehta, Renee M Banakis Hartl","doi":"10.1097/MAO.0000000000004537","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004537","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze the impact of single-sided deafness (SSD) on listening behavior to evaluate sound localization ability, speech-in-noise performance, and quantifying and comparing compensatory head movements in individuals with normal hearing (NH) and SSD, with and without a cochlear implant (CI).</p><p><strong>Study design: </strong>Nonrandomized, prospective, human-subject study.</p><p><strong>Setting: </strong>Tertiary academic medical center.</p><p><strong>Methods: </strong>NH, SSD, and SSD-CI subjects were presented with Harvard IEEE sentences at varying target azimuths in a darkened, semi-anechoic chamber in background noise while head position was monitored. Head movement (total absolute head displacement, onset delay, and response time), localization accuracy, and speech-in-noise performance were analyzed.</p><p><strong>Results: </strong>SSD subjects demonstrated less accurate speech-in-noise and sound localization performance with a significant effect of hearing status and signal-to-noise ratio (SNR). Sound localization benefit with CI was limited and did not improve, with increasingly optimal SNR and speech-in-noise performance reaching the level of NH controls with more optimal SNR. Head movements varied with and without CI for total response time, whereby CI users had shortest response times. There was no difference between the SSD and SSD-CI conditions for onset delay and head displacement, despite significant differences compared with NH controls.</p><p><strong>Conclusions: </strong>Speech-in-noise performance may be the most significant improvement in CI use for SSD. Although sound localization abilities are present, there may be modest clinical significance. Head movement dynamics may highlight adaptive mechanisms that, if integrated into training or device programming, may further improve speech-in-noise and localization abilities.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomical Relationship of Cochlear Basal Turn and Facial Nerve in Patients With Tip Fold-Over During Cochlear Implantation Using Slim Modiolar Electrode. 细孔电极人工耳蜗植入术中尖端折叠患者耳蜗基底转与面神经的解剖关系。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-16 DOI: 10.1097/MAO.0000000000004573
Yeonjoo Choi, Hye Ah Joo, Woo Seok Kang, Joong Ho Ahn, Jong Woo Chung, Hong Ju Park
{"title":"Anatomical Relationship of Cochlear Basal Turn and Facial Nerve in Patients With Tip Fold-Over During Cochlear Implantation Using Slim Modiolar Electrode.","authors":"Yeonjoo Choi, Hye Ah Joo, Woo Seok Kang, Joong Ho Ahn, Jong Woo Chung, Hong Ju Park","doi":"10.1097/MAO.0000000000004573","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004573","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the anatomical factors contributing to tip fold-over (TFO) during electrode insertion in cochlear implantation (CI).</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Setting: </strong>Tertiary care academic center.</p><p><strong>Patients: </strong>A total of 239 ears underwent CI with Slim Modiolar Electrodes (SME) between August 2018 and December 2023.</p><p><strong>Main outcomes and measures: </strong>Preoperative temporal bone CT scans were analyzed to identify differences between patients with and without TFO. The positional relationship between a horizontal line at the cochlear basal turn and the facial nerve was assessed, and the angle between this horizontal line and the lateral margin of the facial nerve was measured.</p><p><strong>Results: </strong>TFO occurred in 4.2% of cases, requiring an average of 2.7 reinsertion attempts for proper placement. In the TFO group, the horizontal line at the cochlear basal turn was positioned below the facial nerve in 90% of cases, compared with only 11.3% in the non-TFO group (p < 0.001). The mean angle between the cochlear basal turn and the facial nerve was -6.7 degrees (±2.9) in the TFO group and -0.4 degrees (±2.7) in the non-TFO group (p < 0.001).</p><p><strong>Conclusion: </strong>TFO is more likely to occur when the facial nerve is positioned laterally relative to the cochlear basal turn, causing the electrode sheath to prematurely contact the scala tympani floor. These findings highlight a potential anatomical risk factor for TFO, emphasizing the need for tailored surgical strategies in high-risk cases.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photon-Counting CT Reveals Radiologically Occult Otospongiosis: A Case Report. 光子计数CT显示隐匿性耳海绵症1例。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-11 DOI: 10.1097/MAO.0000000000004599
Anna Dordonnat, Neil Grislain, Gabriel Garcia, Jean-Noël Vallée, Michael Eliezer
{"title":"Photon-Counting CT Reveals Radiologically Occult Otospongiosis: A Case Report.","authors":"Anna Dordonnat, Neil Grislain, Gabriel Garcia, Jean-Noël Vallée, Michael Eliezer","doi":"10.1097/MAO.0000000000004599","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004599","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma. 与中耳胆脂瘤相关的常见到罕见变异的全基因组和外显子组鉴定。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-10 DOI: 10.1097/MAO.0000000000004594
Ke Qiu, Junhong Li, Ping An, Lin Lou, Tianyi Gu, Xiuli Shao, Min Chen, Minzi Mao, Wendu Pang, Yongbo Zheng, Di Deng, Wei Xu, Jianjun Ren, Yu Zhao
{"title":"Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma.","authors":"Ke Qiu, Junhong Li, Ping An, Lin Lou, Tianyi Gu, Xiuli Shao, Min Chen, Minzi Mao, Wendu Pang, Yongbo Zheng, Di Deng, Wei Xu, Jianjun Ren, Yu Zhao","doi":"10.1097/MAO.0000000000004594","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004594","url":null,"abstract":"<p><strong>Hypothesis: </strong>To investigate the genetic susceptibility of middle ear cholesteatoma (MEC) and construct an MEC risk prediction model by integrating genetic risk with clinical factors.</p><p><strong>Background: </strong>MEC represents a relatively rare disorder that is associated with high morbidity, whereas its genetic etiology remains poorly understood.</p><p><strong>Methods: </strong>Using genetic data from the UK Biobank (UKB), we performed both genome-wide association study (GWAS) and exome-wide association study (ExWAS) involving 702 MEC patients and 491,503 controls. Gene-based and gene set-based association studies were then performed to identify risk genes and gene sets of MEC, respectively. In addition, logistic regression models were applied to identify clinically significant MEC-associated diseases, of which the genetic and causal relationships with MEC were further characterized using linkage disequilibrium score regression, genetic analysis incorporating pleiotropy and annotation, and Mendelian randomization. Moreover, logistic regression models were employed to construct MEC risk prediction models by integrating genetic risk with clinical factors.</p><p><strong>Results: </strong>Our study identified 159 common variants across 8 genomic loci and 39 rare variants spanning 17 genomic regions that were significantly associated with MEC, with PLD1 being prioritized as the top-ranked MEC candidate target gene. Additionally, 10 different types of diseases showed significant associations with MEC, but no inconclusive genetic or causal relationship was established between them. Moreover, we successfully constructed a high-performance MEC risk prediction model with an area under the curve of 0.704, showing the potential for clinical application.</p><p><strong>Conclusions: </strong>These findings advance our understanding of the genetic susceptibility of MEC and provide insights into its risk prediction, thus contributing to improved MEC prevention and management.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the COVID-19 Pandemic and Vaccination on Bell's Palsy: A Retrospective Comprehensive Analysis Using TriNetX Data. COVID-19大流行和疫苗接种对贝尔氏麻痹的影响:使用TriNetX数据的回顾性综合分析
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-10 DOI: 10.1097/MAO.0000000000004597
David Shimunov, Huseyin Isildak
{"title":"Impact of the COVID-19 Pandemic and Vaccination on Bell's Palsy: A Retrospective Comprehensive Analysis Using TriNetX Data.","authors":"David Shimunov, Huseyin Isildak","doi":"10.1097/MAO.0000000000004597","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004597","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bell's palsy (BP), a sudden onset of facial paralysis, has been reported in patients with COVID-19. The relationship between COVID-19 infection and BP remains unclear, as does the impact of COVID-19 vaccination on its incidence. This study aims to assess the occurrence of BP before and after the COVID-19 pandemic and to explore any potential effects of COVID-19 vaccination on BP cases.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study utilized data from the TriNetX global health research network, specifically the US Collaborative Network of 68 healthcare organizations, encompassing 99,852,106 patients with ICD codes from 2016 to 2024. BP cases were identified using ICD-10 code G51.0, while COVID-19 vaccinations and infections were identified using CPT codes and TNX Curated 9088, respectively. We conducted an incidence and prevalence analysis of BP cases annually over the 8-year period to detect trends and compared BP rates between prepandemic (2016-2020) and postpandemic (2020-2024) periods using odds ratios. Additionally, we assessed BP incidence among COVID-19 patients and performed a subgroup analysis on vaccinated individuals to evaluate the impact of vaccination on BP incidence. To reduce potential confounding, we employed propensity score matching using the greedy nearest neighbor method available in the TriNetX platform, matching patients on age, sex, race, type 2 diabetes mellitus, and vascular commodities. Statistical analyses were executed within the TriNetX platform and supplemented by online AI tools using Python.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The analysis of BP cases from 2016 to 2024 revealed an upward trend in both incidence and prevalence. The incidence proportion rose from 48 cases per 100,000 people in 2016-2017 to 69 cases per 100,000 by 2023-2024, with a significant increase noted from 2021 onwards. Similarly, the incidence rate increased from 0.00000155 to 0.00000333 over the same period. Prevalence also showed a steady rise, from 228 to 434 cases per 100,000 people. Trend analyses confirmed these increases as statistically significant, with p-values indicating upward trends in incidence and prevalence. Comparing prepandemic (2016-2020) to postpandemic (2020-2024) periods, there was a significant rise in incidence proportions (p-value ≈ 0.0074) and prevalence rates (p-value = 0.0180). Among COVID-positive patients, the incidence proportion remained stable, while prevalence increased, indicating a higher burden compared to the general population. After propensity score matching, vaccinated individuals exhibited a significantly lower risk of BP compared to unvaccinated individuals (hazard ratio: 0.723, 95% CI: 0.618-0.84, p &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This highlights a significant increase in the incidence and prevalence of BP during the COVID-19 pandemic years compared to prepandemic levels. While the incidence of BP among vaccinated individuals showed a gradual increase, when mitiga","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetrical Auditory Dysfunction as a Potential Nonmotor Lateralizing Sign in Parkinson's Disease: A Case-Control Study. 不对称听觉功能障碍是帕金森病潜在的非运动偏侧症状:一项病例对照研究
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-10 DOI: 10.1097/MAO.0000000000004598
Reham Mamdouh Lasheen, Mohamed Nasser Elsheikh, Mohamed Osama Tomoum
{"title":"Asymmetrical Auditory Dysfunction as a Potential Nonmotor Lateralizing Sign in Parkinson's Disease: A Case-Control Study.","authors":"Reham Mamdouh Lasheen, Mohamed Nasser Elsheikh, Mohamed Osama Tomoum","doi":"10.1097/MAO.0000000000004598","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004598","url":null,"abstract":"<p><strong>Introduction: </strong>Parkinson's disease (PD) is a complex neurodegenerative disorder that often presents with unilateral motor symptoms at the onset. While motor symptoms such as tremor, bradykinesia, rigidity, and postural instability are the signs of PD, nonmotor symptoms also significantly impact the patient's quality of life. One such nonmotor symptom is auditory dysfunction, which has been increasingly recognized as a feature of PD.</p><p><strong>Objectives: </strong>Our purpose is to evaluate auditory impairment in PD patients and its asymmetry as a biomarker to differentiate PD from other neurodegenerative disorders that do not exhibit this lateralized auditory dysfunction.</p><p><strong>Subjects and methodology: </strong>Our study included 60 patients with parkinsonism \"the study group\", and 40 healthy individuals \"the control group.\" All participants underwent three auditory tests: pure tone audiometry (PTA), auditory brainstem response (ABR), and otoacoustic emissions (OAE).</p><p><strong>Results: </strong>PTA thresholds were significantly higher in the PD group, especially on the affected side. ABR absolute latencies and interpeak latencies were significantly delayed in PD, with the delays being more pronounced on the affected side. The distortion product OAEs showed a significant decrease in amplitude on the affected side compared to the nonaffected side. Furthermore, its amplitude was highly significantly reduced when compared to the control group.</p><p><strong>Conclusion: </strong>The asymmetry of the audiological responses in PD patients could be a valuable nonmotor marker of PD, enhancing our understanding of its broader impact on sensory systems and aiding in more precise diagnosis and monitoring of the disease.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vestibular Dysfunction in Pediatric Patients With Congenital Cytomegalovirus Infection and Hearing Loss: Occurrence and Characteristics. 先天性巨细胞病毒感染和听力损失的儿童前庭功能障碍:发生和特点。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-07 DOI: 10.1097/MAO.0000000000004600
Guangwei Zhou, Hannah Peterson, Alice Yun, Jacob Brodsky
{"title":"Vestibular Dysfunction in Pediatric Patients With Congenital Cytomegalovirus Infection and Hearing Loss: Occurrence and Characteristics.","authors":"Guangwei Zhou, Hannah Peterson, Alice Yun, Jacob Brodsky","doi":"10.1097/MAO.0000000000004600","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004600","url":null,"abstract":"<p><strong>Objective: </strong>To explore the occurrence of vestibular dysfunction in pediatric patients with congenital cytomegalovirus (CMV) infection and define the characteristics of vestibular loss in this population.</p><p><strong>Study design: </strong>Retrospective study with controls.</p><p><strong>Setting: </strong>Tertiary pediatric referral center.</p><p><strong>Patients: </strong>Pediatric patients with hearing loss associated with congenital CMV infection and GJB2 mutation(s).</p><p><strong>Interventions: </strong>Balance and vestibular evaluation.</p><p><strong>Main outcome measures: </strong>Normal versus abnormal results of laboratory vestibular testing.</p><p><strong>Results: </strong>A total of 50 pediatric patients with congenital CMV infection, average age = 3.4 years (ranging from 7 mo to 12 yr, SD = 2.9 yr), underwent vestibular workup, including Videonystagmography, rotary chair test, and cervical vestibular evoked myogenic potential test. Of these children with CMV infection, 35 (70%) had bilateral vestibular loss, 7 (14%) had unilateral loss, and only 8 (16%) had a normal vestibular workup. In contrast, among the 48 pediatric patients without a history of CMV infection and with hearing loss associated with GJB2 mutation(s), only 9 (19%) had bilateral vestibular loss, 2 (4%) had unilateral loss, while 37 (77%) had a normal vestibular workup. Developmental/motor delay was documented in 35 (70%) patients with congenital CMV infection and hearing loss.</p><p><strong>Conclusions: </strong>Children with congenital CMV infection are at high risk for vestibular loss, which is frequently bilateral, impacting the semicircular canals and otolith organs, not just the well-known hearing loss. A comprehensive balance and vestibular workup is warranted for children with congenital CMV infection with the goal of early identification of vestibular dysfunction and earlier management.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review of the Incidence of Cochlear Nerve Deficiency in Pediatric Single-Sided Deafness. 小儿单侧耳聋中耳蜗神经缺损发生率的系统综述。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-01 Epub Date: 2025-02-24 DOI: 10.1097/MAO.0000000000004474
Christina Zhu, Jasmine Gulati, Daniel Swanson, Anuja Shah, Paul Chisolm, Michael Hoa
{"title":"A Systematic Review of the Incidence of Cochlear Nerve Deficiency in Pediatric Single-Sided Deafness.","authors":"Christina Zhu, Jasmine Gulati, Daniel Swanson, Anuja Shah, Paul Chisolm, Michael Hoa","doi":"10.1097/MAO.0000000000004474","DOIUrl":"10.1097/MAO.0000000000004474","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the variability in cochlear nerve deficiency (CND) incidence in pediatric single-sided deafness (SSD), assess how study parameters and inclusion criteria affect these rates, and examine the diagnostic tools utilized, including magnetic resonance imaging (MRI) and computed tomography (CT), in identifying CND.</p><p><strong>Data sources: </strong>Databases including MEDLINE, Embase, Cochrane CENTRAL, and Web of Science.</p><p><strong>Review methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines with predefined search criteria using terms related to pediatric unilateral hearing loss and CND from 2010 to January 2024. Studies were selected based on their focus on CND incidence in pediatric SSD, excluding case reports, nonhuman or adult studies, and analyses limited to bilateral deafness.</p><p><strong>Results: </strong>Out of 518 articles screened, 17 underwent full-text review, and 10 were included. Incidence rates of CND ranged from 15.7% to 100%, with all studies using MRI and 60% using CT as an adjunct diagnostic tool. Age criteria varied: five studies included patients 18 years and older, one study included patients up to age 21 years, and four studies targeted children under 5 years, including two studies on neonates. Variability stemmed from differing inclusion criteria; studies on younger cohorts generally excluded noncongenital causes, while older children's studies were less restrictive. Additionally, two studies excluded syndromic SSD, impacting incidence rates. Larger studies show an overall incidence of 35% to 45%, which this systematic review of the literature reports as the approximate incidence of CND in SSD, with higher incidence rates observed in studies excluding syndromic causes and broader criteria linked to decreased incidence.</p><p><strong>Conclusion: </strong>This systematic review highlights how age-specific inclusion criteria and management of syndromic causes significantly influence reported CND incidence rates in pediatric SSD, underscoring the need for standardized reporting to improve clinical understanding and treatment approaches.Level of Evidence: 1.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"668-674"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Image Quality Improvement in MRI of Cochlear Implants and Auditory Brainstem Implants After Metal Artifact Reduction Techniques. 金属伪影还原技术后耳蜗和听觉脑干植入体MRI图像质量的改善。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-07-01 Epub Date: 2025-05-01 DOI: 10.1097/MAO.0000000000004517
Arianna Winchester, Justin Cottrell, Emily Kay-Rivest, David Friedmann, Sean McMenomey, J Thomas Roland, Mary Bruno, Mari Hagiwara, Gul Moonis, Daniel Jethanamest
{"title":"Image Quality Improvement in MRI of Cochlear Implants and Auditory Brainstem Implants After Metal Artifact Reduction Techniques.","authors":"Arianna Winchester, Justin Cottrell, Emily Kay-Rivest, David Friedmann, Sean McMenomey, J Thomas Roland, Mary Bruno, Mari Hagiwara, Gul Moonis, Daniel Jethanamest","doi":"10.1097/MAO.0000000000004517","DOIUrl":"10.1097/MAO.0000000000004517","url":null,"abstract":"<p><strong>Objective: </strong>Observe if metal artifact reduction (MAR) techniques applied to magnetic resonance imaging (MRI) performed on patients with cochlear implants (CI) or auditory brainstem implants (ABI) improves image quality.</p><p><strong>Study design: </strong>Retrospective review.</p><p><strong>Setting: </strong>Tertiary care center.</p><p><strong>Patients: </strong>Patients with auditory implants who underwent clinical MRI before and after the application of MAR techniques previously described.</p><p><strong>Interventions: </strong>From September 2022 to March 2023, patients who underwent brain or internal auditory canal (IAC) MRI with and without MAR were identified. Sequences included T1 and T2 weighted with turbo-spin-echo (TSE) correction and fluid-attenuation inversion recovery (FLAIR). Images were analyzed for visualization of intracranial structures by two neuroradiologists.</p><p><strong>Main outcome measures: </strong>Visibility of 14 structures graded on a four-point Likert scale. Average scores per structure and sequence were compared using paired two-tailed t -tests and change in mode score.</p><p><strong>Results: </strong>Ten patients underwent pre- and post-MAR MRI. Six had a unilateral CI, three had a unilateral ABI, and one had an ABI and CI. Three patients had four devices with the internal magnet removed for both scans. All structures had significantly improved visibility on post-MAR scan except ipsilateral parietal and occipital lobes and contralateral inner ear. Mode score increased from 2 to 4 for the ipsilateral occipital lobe and from 3 to 4 for the ipsilateral semicircular canals, brainstem, and cerebellar peduncles. Significant improvement was seen in all sequences except for ipsilateral structures on T1w axial precontrast and contralateral structures on T1w coronal postcontrast. ABIs did not improve as much as CIs because they scored better on the pre-MAR scan.</p><p><strong>Conclusions: </strong>MAR techniques improve image quality for patients with MRI-compatible implants with magnets. Benefits may be more evident in CIs than ABIs.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"641-647"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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