Otology & Neurotology最新文献

{"title":"Modified Push-Through Technique in Bilateral Same-Day Myringoplasty: A Prospective Study.","authors":"Alper Tabaru, Ozgur Yıgıt, Salih Akyel, Zeliha Kapusuz Gencer, Sahin Ogreden, Iskender Bayram","doi":"10.1097/MAO.0000000000004493","DOIUrl":"10.1097/MAO.0000000000004493","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy and safety of the modified push-through technique in bilateral same-day myringoplasty for patients with chronic otitis media. Bilateral myringoplasty, while advantageous in terms of cost and recovery time, is often avoided due to the perceived risks, particularly iatrogenic sensorineural hearing loss (SNHL). This study contributes to the limited literature on simultaneous bilateral ear surgeries by assessing surgical outcomes, including graft success rates and postoperative hearing improvement.</p><p><strong>Methods: </strong>A prospective study was conducted on 50 patients (100 ears) undergoing bilateral same-day myringoplasty at a tertiary care center. The modified push-through technique was employed for all surgeries. Postoperative follow-up was carried out at 1, 3, and 6 months, with evaluations including otomicroscopy and audiometric testing. The primary outcome was graft take rate, and secondary outcomes included air-bone gap (ABG) reduction and incidence of SNHL.</p><p><strong>Results: </strong>The study demonstrated a graft success rate of 94% across the 100 operated ears. Postoperative audiometry revealed significant improvement in hearing, with the ABG reduced from a preoperative mean of 20 dB to a postoperative mean of 10 dB ( p < 0.001). No cases of SNHL were observed.</p><p><strong>Conclusion: </strong>Bilateral same-day myringoplasty using the modified push-through technique is a viable surgical option for patients with chronic otitis media, offering high graft success rates and significant hearing improvement without increasing the risk of SNHL. This technique could be considered a preferred approach in suitable patients, potentially reducing the need for multiple surgical interventions and associated healthcare costs.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e183-e189"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deafness Progressing to Cochlear Implant Eligibility Is Eight Times More Likely in the Hypoplastic Than the Degenerative Endotype of Menière's Disease.","authors":"Catrin Brühlmann, Jennifer L Spiegel, Agnes Mühle, Adrian Dalbert, Vincent Y W Lin, Trung N Le, Thore Schade-Mann, Jessica Knoppik, Dorothe Veraguth, Christof Rö Ösli, Alexander Huber, Julia Dlugaiczyk, Steven D Rauch, Hubert Löwenheim, Joseph M Chen, Amy F Juliano, Andreas H Eckhard, David Bächinger","doi":"10.1097/MAO.0000000000004482","DOIUrl":"10.1097/MAO.0000000000004482","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether one of the two recently described MD endotypes-defined by either endolymphatic sac degeneration (MD-dg patients) or hypoplasia (MD-hp patients)-is associated with an increased likelihood of undergoing CI.</p><p><strong>Study design: </strong>Retrospective multicenter cross-sectional study.</p><p><strong>Setting: </strong>Five tertiary referral centers.</p><p><strong>Patients: </strong>CI cohort: 115 adult MD patients with a history of uni- or bilateral CI. Non-CI cohort: 72 MD patients with no CI history. All included patients matched current diagnostic criteria for definite MD.</p><p><strong>Intervention: </strong>Cochlear implantation.</p><p><strong>Main outcome measures: </strong>Endotype distribution (MD-dg versus MD-hp) between the CI cohort and the non-CI cohort. The endotype was determined using high-resolution CT data based on the angular trajectory of the vestibular aqueduct, following established protocols. Secondary outcomes included disease laterality, age at MD diagnosis, duration of MD, and pre-CI hearing thresholds.</p><p><strong>Results: </strong>The CI cohort included significantly more MD-hp patients than the non-CI cohort (72% versus 24%, p < 0.0001). The odds ratio of CI for an MD-hp patient relative to an MD-dg patient was 8.4 (95% confidence interval, 4.3-16.1). Pre-CI audiometric data showed no significant differences in hearing thresholds between endotypes, neither in the implanted nor in the non-implanted ear.</p><p><strong>Conclusions: </strong>The MD-hp endotype, frequently associated with bilateral disease and early-age disease onset, is strongly linked to a higher likelihood of CI. Endotyping of MD patients based on endolymphatic sac pathology can effectively stratify their risk of severe hearing loss, guiding personalized audiological follow-up and clinical decisions regarding potential CI.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e170-e175"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin Type A Injection Near the Stylomastoid Foramen: A Safe and Effective Therapeutic Modality for Tinnitus in Patients With Hemifacial Spasm.","authors":"Lingxi Zhu, Lizhen Pan, Xiaolong Zhang, Yougui Pan, Lingjing Jin, Fei Teng","doi":"10.1097/MAO.0000000000004542","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004542","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the efficacy and safety of botulinum toxin type A (BTX-A) injection near the stylomastoid foramen for tinnitus in patients with hemifacial spasm (HFS).</p><p><strong>Study design: </strong>Retrospective study from 2011 to 2024.</p><p><strong>Setting: </strong>Tongji Hospital affiliated to Tongji University in Shanghai, China.</p><p><strong>Patients: </strong>Patients with HFS combined with tinnitus.</p><p><strong>Intervention: </strong>BTX-A injection near the stylomastoid foramen.</p><p><strong>Main outcome measures: </strong>The efficacy of BTX-A was assessed based on subjective improvement reported by patients after 1 month. Adverse events were also documented.</p><p><strong>Results: </strong>A total of 869 HFS patients were analyzed, including 122 with tinnitus. Among the 122 patients with tinnitus, 110 received BTX-A injections near the stylomastoid foramen, and complete follow-up data were available for 105 of them. The 3.75 U group showed a higher improvement rate (69.2 ± 14.3%) compared with the 2.5 U group (46.3 ± 25.0%, p < 0.05). The majority received a 5 U dose, with a significantly higher improvement rate (76.9 ± 15.1%) compared with the 2.5 U group (p < 0.01). All reported adverse events were related to routine injection sites and were mild, requiring no special treatment. No adverse events related to BTX-A injection near the stylomastoid foramen were reported.</p><p><strong>Conclusion: </strong>In patients with HFS-associated tinnitus, additional injection of 5 U BTX-A near the stylomastoid foramen, targeting the stapedius muscle, proved to be an effective therapy with minimal adverse effects.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Controlled Trial Comparing Outcomes for Adult Cochlear Implant Recipients Using a Lateral Wall or Perimodiolar Electrode Array.","authors":"Robert J S Briggs, Timothy McLean, Alexandra Rousset, Sylvia Tari, Stephen J O'Leary, Richard C Dowell, Jaime Leigh, Robert Cowan","doi":"10.1097/MAO.0000000000004518","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004518","url":null,"abstract":"<p><strong>Objective: </strong>The primary aim of this study was to compare outcomes of adult cochlear implant recipients receiving either perimodiolar or lateral wall electrode arrays.</p><p><strong>Study design: </strong>A prospective randomized controlled study was conducted to investigate final electrode array position, speech perception, and vestibular symptoms.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>One hundred forty-four adults were assessed for the study. Inclusion criteria were bilateral postlingual severe to profound sensorineural hearing loss, with 500-Hz threshold in the implant ear of 75 dB HL or greater.</p><p><strong>Interventions: </strong>Subjects were randomized to receive either perimodiolar or lateral wall electrode arrays.</p><p><strong>Main outcome measures: </strong>Postoperative electrode array position was assessed by cone-beam computed tomography. Speech perception was measured preoperatively in best-aided conditions, and 3 and 12 months postoperatively. Vestibular symptoms were assessed using two self-reported questionnaires and/or clinician reports.</p><p><strong>Results: </strong>Postoperative speech perception results for 124 implants in 123 adults showed significant improvement from preoperative scores and from 3 to 12 months postoperatively. Multiple regression analysis indicated no significant effect of electrode array position for any speech perception results at 3 and 12 months postoperatively. Auditory alone, monosyllabic word, and phoneme scores at 12 months were 48.4 and 71.4% for lateral wall electrode arrays and 49.8% and 72.0% for perimodiolar electrode arrays, respectively. No relationships between angle (depth) of electrode array insertion and speech perception outcomes were detected. There was no significant difference in incidence of vestibular symptoms between the groups.</p><p><strong>Conclusions: </strong>Correct scala tympani placement of either the perimodiolar or lateral wall electrode arrays used in this study provides excellent speech perception outcomes, with no significant difference demonstrated between groups.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear Implantation of Slim Precurved Arrays Using Automatic Preoperative Insertion Plans.","authors":"Kareem O Tawfik, Mohammad M R Khan, Ankita Patro, Miriam R Smetak, David Haynes, Robert F Labadie, René H Gifford, Jack H Noble","doi":"10.1097/MAO.0000000000004525","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004525","url":null,"abstract":"<p><strong>Hypothesis: </strong>Preoperative cochlear implant (CI) electrode array (EL) insertion plans created by automated image analysis methods can improve positioning of slim precurved EL.</p><p><strong>Background: </strong>This study represents the first evaluation of a system for patient-customized EL insertion planning for a slim precurved EL.</p><p><strong>Methods: </strong>Twenty-one temporal bone specimens were divided into experimental and control groups and underwent cochlear implantation. For the control group, the surgeon performed a traditional insertion without an insertion plan. For the experimental group, customized insertion plans guided entry site, trajectory, curl direction, and base insertion depth. An additional 35 clinical insertions from the same surgeon were analyzed, 7 of which were conducted using the insertion plans. EL positioning was analyzed using postoperative imaging auto-segmentation techniques, allowing measurement of angular insertion depth (AID), mean modiolar distance (MMD), and scalar position.</p><p><strong>Results: </strong>In the cadaveric temporal bones, three scalar translocations, including two foldovers, occurred in 14 control group insertions. In the clinical insertions, translocations occurred in 2 of 28 control cases. No translocations or folds occurred in the seven experimental temporal bone and the seven experimental clinical insertions. Among the nontranslocated cases, overall AID and MMD were 401 ± 41 degrees and 0.34 ± 0.13 mm for the control insertions. AID and MMD for the experimental insertions were 424 ± 43 degrees and 0.34 ± 0.09 mm overall and were 432 ± 19 degrees and 0.30 ± 0.07 mm for cases where the planned insertion depth was achieved.</p><p><strong>Conclusions: </strong>Trends toward improved EL positioning within scala tympani were observed when EL insertion plans are used. Variability in MMD was significantly reduced (0.07 versus 0.13 mm, p = 0.039) when the planned depth was achieved.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing Preservation of Slim Modiolar and Slim Straight Electrodes: A Systematic Review and Meta-Analysis.","authors":"Shuang Geng, Sudanthi Wijewickrema, Bridget Copson, Jean-Marc Gerard, Stephen O'Leary","doi":"10.1097/MAO.0000000000004540","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004540","url":null,"abstract":"<p><strong>Purpose: </strong>This meta-analysis aims to investigate the hearing preservation (HP) rates of slim straight electrodes (SSE) and slim modiolar electrodes (SME) after cochlear implantation, in the short- and long-term (≤4 months and 4-12 months, respectively).</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Embase, Cochrane Library, and ClinicalTrials databases for studies published between 1 January, 2014, and 1 January, 2024. Cohort studies, case series, and randomized controlled trials written in English, reporting HP rates using the HEARRING classification system, were included.</p><p><strong>Results: </strong>Sixteen studies were included, comprising 15 observational studies and 1 randomized controlled trial. The overall short-term HP rate for SSE was 68.70% (95% CI: 52.27-85.12%), which decreased to 56.38% (95% CI: 42.87-69.90%) in the long-term. In contrast, SME maintained stable HP rates of 59.07% (95% CI: 50.03-68.10%) in the short-term, and 59.09% (95% CI: 46.48-71.70%) in the long-term.</p><p><strong>Conclusion: </strong>The meta-analysis revealed that SME and SSE have a similar HP ability in both the short- and long-terms. Notably, a prominent decline in HP rate over time was observed in the SSE compared with SME.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of CT Radiation Dose and Field-of-View on Automatic Morphometry for Cochlear Implant Planning.","authors":"Henner Huflage, Tobias Wech, Kristen Rak, Magnus Schindehuette, Jonas Engert, Stephan Hackenberg, Mirko Pham, Thorsten Alexander Bley, Jan-Peter Grunz, Bjoern Spahn","doi":"10.1097/MAO.0000000000004534","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004534","url":null,"abstract":"<p><strong>Introduction: </strong>In cochlear implantation (CI), precise preoperative cochlear duct length (CDL) and angular insertion depth (AID) measurements are pivotal for individualized electrode carrier selection, since recipients benefit from sufficient cochlear coverage of the electrode carrier, enabling electric stimulation of all crucial frequency bands. Since the quality of temporal bone CT largely depends on acquisition and reconstruction settings and is limited by the technical capabilities of the CT scanner, this study aims to assess how radiation dose and reconstruction field-of-view (FOV) affect automatic cochlear morphometry and electrode contact determination in conventional multislice CT.</p><p><strong>Methods: </strong>Twenty fresh-frozen human petrous bone specimens were examined at three radiation dose levels (40, 20, and 10 mGy) using a multislice CT scanner. Each dataset was reconstructed with three different FOV settings (250, 125, and 50 mm). Preoperative CDL and AID measurements were performed with dedicated otological planning software. Maxed-out dose images (250 mGy) served as standard of reference for comparing the morphometric results.</p><p><strong>Results: </strong>Regardless of the selected combination of dose level and FOV, significant CDL or AID measurement differences were neither ascertained among the individual groups, nor in comparison to the reference scans (all p ≥ 0.05). Likewise, the simulation of all stimulable frequency bandwidths showed no dependency on radiation dose or FOV settings (all p ≥ 0.05).</p><p><strong>Conclusion: </strong>The assessment of cochlear morphometry with conventional multislice CT imaging before CI surgery allowed a radiation dose reduction up to 75% without compromising the accuracy of software-based cochlear analysis. Notably, automatic CDL and AID measurements for surgical planning did not benefit from a smaller reconstruction FOV.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Outcomes of the 445-nm Blue Light Laser for Stapedotomy.","authors":"Regan C Manayan, Victoria W Huang, James G Naples","doi":"10.1097/MAO.0000000000004539","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004539","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of the 445-nm blue light laser in stapedotomy, compared with the CO2 laser.</p><p><strong>Patients: </strong>Patients 18 years or older with a history of otosclerosis who underwent stapedotomy with either carbon dioxide (CO2) or blue light (BL) laser from September 2020 to May 2024. Patients who had revision surgery, underwent stapedotomy without the use of CO2 or BL laser, or were without an available preoperative or postoperative audiogram were excluded.</p><p><strong>Intervention: </strong>Stapedotomy with the 445-nm BL laser.</p><p><strong>Main outcome measure: </strong>Postoperative improvement in air-bone gap (ABG) on audiogram for patients who underwent stapedotomy with BL laser, as compared with those who underwent stapedotomy with CO2 laser.</p><p><strong>Results: </strong>Thirty-two patients were included in the final cohort, with 16 patients in the CO2 laser and BL laser groups, respectively. Although there was no significant difference in the postoperative ABG between the CO2 and BL laser groups (9.1 versus 6.5 dB, p = 0.27), there was a difference in the number of footplate fractures between the CO2 and TB laser groups, although this neither was significant (0 versus 3 events, p = 0.23) nor impacted hearing status.</p><p><strong>Conclusion: </strong>The BL laser offers comparable closure of the ABG in stapes surgery, as well as a similar safety profile, when compared with the CO2 laser.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale for the Development of a Universal Hearing Metric for Public Consumption: Initiative 1 of the Hearing Health Collaborative.","authors":"Nicholas S Reed, Sahar Assi, Matthew Bush, Matthew L Carlson, Maura Cosetti, Liza Creel, Samuel Gubbels, Richard Gurgel, Meredith Holcomb, Anna M Jilla, Frank R Lin, John P Marinelli, Clarice Myers, Douglas P Sladen, Christopher Spankovich, Sarah Sydlowski, Bevan Yueh, Ashley M Nassiri","doi":"10.1097/MAO.0000000000004523","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004523","url":null,"abstract":"<p><strong>Objective: </strong>Present the rationale for the development of a new, patient-facing vital sign for adult hearing.</p><p><strong>Study design: </strong>Structured A3 process.</p><p><strong>Setting: </strong>Fourteen virtual meetings and two in-person meetings held between May 2021 and June 2022.</p><p><strong>Main outcome measures: </strong>Identification and refinement of a countermeasure to develop and imbed a hearing health vital sign for adult hearing.</p><p><strong>Results: </strong>Through a rigorous, structured A3 process, the Hearing Health Collaborative identified and refined the rationale for and the qualities associated with a public-facing vital sign for adult hearing loss. Specifically, such a vital sign must embody five qualities: simple, accessible, stable, inclusive, and meaningful. These qualities together would ensure that a hearing health vital sign would be useful not only as a screening tool but also as an instrument to guide next steps in workup and potentially treatment.</p><p><strong>Conclusions: </strong>Successful identification and implementation of a hearing metric or \"vital sign\" for the presence of adult hearing loss, using precedent convention of other medical diseases, may help reframe public perceptions surrounding hearing loss, improve awareness and literacy regarding the presence of the disease, and prompt action to seek diagnostic assessment.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab.","authors":"Ethan M Kallenberger, Snimarjot Kaur, Brynn E Everist, Gregory A Ator, Selina A Gierer, Andrea F D'Mello","doi":"10.1097/MAO.0000000000004501","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004501","url":null,"abstract":"<p><strong>Objective: </strong>To highlight the efficacy of dupilumab in treating chronic otitis media with effusion (glue ear).</p><p><strong>Patients: </strong>Three patients with chronic otitis media with effusion (OME) refractory to medical and surgical treatment were retrospectively identified. All patients had medical history suggestive of the presence of eosinophilic inflammation.</p><p><strong>Interventions: </strong>Each patient received a 300-mg injection of dupilumab every 4 weeks for a total of three injections.</p><p><strong>Main outcome measures: </strong>Audiometric data, patient-reported incidence of new ear infections, patient-reported symptoms.</p><p><strong>Results: </strong>All patients reported subjective improvement in ear pain, drainage, and hearing loss between 2 weeks and 6 months on dupilumab therapy. In case 1 and case 2, audiograms showed some improvement in hearing loss posttreatment. Case 2 had an unexpected interruption of treatment for 4 weeks and reported return of thick ear drainage and difficulty with hearing.</p><p><strong>Conclusions: </strong>Dupilumab may be a novel, effective, and nonsurgical treatment option for patients with chronic otitis media with effusion and underlying atopic conditions.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}