Otology & Neurotology最新文献

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Pathophysiology of Acquired Cholesteatoma Associated With Habitual Sniffing: An Analysis Based on Mastoid Cell Development and Contralateral Ear Status. 习惯性嗅探相关获得性胆脂瘤的病理生理:基于乳突细胞发育和对侧耳状态的分析。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-04 DOI: 10.1097/MAO.0000000000005064
Yuta Shimizu, Yutaka Yamamoto, Takara Nakazawa, Motoki Hirabayashi, Sho Kurihara, Masahiro Takahashi, Kazuhisa Yamamoto, Hiromi Kojima
{"title":"Pathophysiology of Acquired Cholesteatoma Associated With Habitual Sniffing: An Analysis Based on Mastoid Cell Development and Contralateral Ear Status.","authors":"Yuta Shimizu, Yutaka Yamamoto, Takara Nakazawa, Motoki Hirabayashi, Sho Kurihara, Masahiro Takahashi, Kazuhisa Yamamoto, Hiromi Kojima","doi":"10.1097/MAO.0000000000005064","DOIUrl":"https://doi.org/10.1097/MAO.0000000000005064","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association of habitual sniffing with mastoid cell development and contralateral ear abnormalities in acquired pars flaccida cholesteatoma.</p><p><strong>Study design: </strong>Retrospective comparative study.</p><p><strong>Setting: </strong>Two tertiary referral hospitals.</p><p><strong>Patients: </strong>A total of 124 adults (133 ears) underwent primary surgery for acquired pars flaccida cholesteatoma between 2012 and 2026.</p><p><strong>Interventions: </strong>Primary cholesteatoma surgery.</p><p><strong>Main outcome measures: </strong>Mastoid cell development score classified according to the Japan Otological Society criteria and abnormal contralateral ear findings.</p><p><strong>Results: </strong>Habitual sniffing was identified in 67 of 133 ears (50.4%). The sniffing group had higher MC scores than the non-sniffing group, indicating better mastoid cell development (1.48±0.68 vs. 1.17±0.67; effect size r=0.222; P=0.010). Ordinal logistic regression showed that habitual sniffing was independently associated with better mastoid cell development [odds ratio (OR)=2.35; 95% confidence interval (CI), 1.15-4.87; P=0.020]. Among 110 ears with evaluable contralateral endoscopic findings, contralateral abnormalities were more frequent in the sniffing group than in the nonsniffing group (71.4% vs. 35.2%; OR=4.536; P=0.0002). Binary logistic regression showed that habitual sniffing was independently associated with abnormal contralateral ear findings (OR=4.57; 95% CI, 1.94-11.34; P=0.0007).</p><p><strong>Conclusions: </strong>Habitual sniffing was associated with better mastoid cell development and frequent contralateral ear abnormalities in acquired pars flaccida cholesteatoma, suggesting a distinct pathophysiologic subgroup related to dynamic negative pressure loading.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-Adjusted Risk of Bone-Anchored Hearing Device Explantation Following Early and Recurrent Wound Complications. 早期和复发性伤口并发症后骨锚定助听器外植的时间调整风险。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-03 DOI: 10.1097/MAO.0000000000005046
Tyler J Gathman, Julio Roque, Lulia Kana, Anagha Srivatsa, Izza Ali, Masanari Kato, Hyunseo Jung, Rachel Goffeney, Sandra Porps, Seilesh Babu
{"title":"Time-Adjusted Risk of Bone-Anchored Hearing Device Explantation Following Early and Recurrent Wound Complications.","authors":"Tyler J Gathman, Julio Roque, Lulia Kana, Anagha Srivatsa, Izza Ali, Masanari Kato, Hyunseo Jung, Rachel Goffeney, Sandra Porps, Seilesh Babu","doi":"10.1097/MAO.0000000000005046","DOIUrl":"https://doi.org/10.1097/MAO.0000000000005046","url":null,"abstract":"<p><strong>Objective: </strong>The objective was to examine the time-adjusted risk of explantation of bone-anchored hearing devices following wound complications after primary implantation.</p><p><strong>Study design: </strong>Retrospective cohort study at a tertiary care neurotology center.</p><p><strong>Patients: </strong>Adults 18 years or older with primary bone-anchored hearing implants from 2003 to 2025, with available audiogram and medical history. Excluded were patients with incomplete data, prior implantations, or immediate postoperative loss to follow-up.</p><p><strong>Outcomes: </strong>The primary outcome was the incidence of device explantation following early (<60 days) or recurrent (>3 episodes) wound complications. The Cox proportional hazards framework with time-dependent modeling was applied for analysis.</p><p><strong>Results: </strong>A total of 1090 surgical ears (666 female, 61.1%; 8 bilateral) underwent primary device implantation, with 127 (11.7%) undergoing explantation; median follow-up was 4.40 years (IQR: 1.66-7.98 y). Patients who underwent explantation were more likely to experience early (HR: 2.30; 95% CI: 1.53-3.45; P<0.001) and frequent (HR: 5.29; 95% CI: 3.62-7.72; P<0.001) wound complications. The cumulative incidence of device explantation at 10 years among patients with frequent wound complications was 60.6% (95% CI: 45.5%-71.5%), compared with 15.6% (95% CI: 11.9%-19.9%) among patients without such complications. After adjustment, frequent wound complications remained significantly associated with the device removal (aHR: 4.60; 95% CI: 2.82-7.51; P<0.001).</p><p><strong>Conclusions: </strong>Recurrent wound complications are associated with nearly a fivefold increase in hazard for device explantation, supporting the need for risk stratification, monitoring, and earlier intervention.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Middle Ear Cholesteatoma in a Postmortem Temporal Bone: A Case Highlighting Variation in Regional Inflammation. 死后颞骨中耳胆脂瘤:一个突出区域炎症变异的病例。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-02 DOI: 10.1097/MAO.0000000000005048
Nathan M Jacob, Amanda M Lauer, Zahra N Sayyid
{"title":"Middle Ear Cholesteatoma in a Postmortem Temporal Bone: A Case Highlighting Variation in Regional Inflammation.","authors":"Nathan M Jacob, Amanda M Lauer, Zahra N Sayyid","doi":"10.1097/MAO.0000000000005048","DOIUrl":"https://doi.org/10.1097/MAO.0000000000005048","url":null,"abstract":"<p><p>Cholesteatoma is an abnormal accumulation of keratinizing squamous epithelium within the middle ear that can behave in a locally destructive manner and erode the ossicular chain. Chronic inflammation and Eustachian tube dysfunction is thought to drive this process. We present a temporal bone specimen from a 38-year-old woman with a lifelong history of right-sided otorrhea and conductive hearing loss, who died of hypoxic-ischemic brain injury after cardiac arrest. Histologic examination revealed a cholesteatoma eroding the incus, with marked regional variation in perimatrix inflammation ranging from mild fibrosis to dense inflammatory infiltration with neovascularization. Notably, areas of more severe inflammation corresponded to a thicker, hyperplastic epithelial matrix, illustrating within a single specimen the spatial link between the inflammatory microenvironment and epithelial proliferation proposed to underlie cholesteatoma progression and local tissue destruction.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twelve-Month Outcomes After Hearing Rehabilitation With an Active Middle Ear Implant and Latest Generation Vibroplasty Couplers in Adults And Children: A Prospective Multicenter Study. 一项前瞻性多中心研究:成人和儿童使用主动中耳植入和最新一代振动成形术耦合器进行听力康复后12个月的结果
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-02 DOI: 10.1097/MAO.0000000000005034
Kristen Rak, Stefan K Plontke, Thomas Lenarz, Daniela Hollfelder, Piotr H Skarzynski, Georg M Sprinzl, Marcus Neudert, John-Martin Hempel, Wafaa Shehata-Dieler, Rudolf Hagen, Torsten Rahne, Anke Lesinski-Schiedat, Nicole Knölke, Susan Busch, Karl-Ludwig Bruchhage, Astrid Magele, Philipp Schörg, Marlene Pollotzek, Wilma Großmann, Nora M Weiss, Carmen Giefing-Kröll, Gabriella Bock, Robert Mlynski
{"title":"Twelve-Month Outcomes After Hearing Rehabilitation With an Active Middle Ear Implant and Latest Generation Vibroplasty Couplers in Adults And Children: A Prospective Multicenter Study.","authors":"Kristen Rak, Stefan K Plontke, Thomas Lenarz, Daniela Hollfelder, Piotr H Skarzynski, Georg M Sprinzl, Marcus Neudert, John-Martin Hempel, Wafaa Shehata-Dieler, Rudolf Hagen, Torsten Rahne, Anke Lesinski-Schiedat, Nicole Knölke, Susan Busch, Karl-Ludwig Bruchhage, Astrid Magele, Philipp Schörg, Marlene Pollotzek, Wilma Großmann, Nora M Weiss, Carmen Giefing-Kröll, Gabriella Bock, Robert Mlynski","doi":"10.1097/MAO.0000000000005034","DOIUrl":"https://doi.org/10.1097/MAO.0000000000005034","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the audiological efficacy, patient-reported outcomes, and safety of an active middle ear implant (AMEI) in children and adults with distinct coupling options.</p><p><strong>Study design: </strong>Prospective, longitudinal, multicenter, noninterventional observational study with repeated within-subject measures and a 12-month follow-up.</p><p><strong>Setting: </strong>Nine tertiary referral centers in Germany, Austria, and Poland.</p><p><strong>Patients: </strong>Adults and children with sensorineural, conductive, or mixed hearing loss. Adults were grouped by coupling method: incus long process (LP), incus short process (SP), round window (RW), or stapes head (SH); multiple couplers were used in children.</p><p><strong>Intervention: </strong>AMEI with coupler.</p><p><strong>Main outcome measures: </strong>The primary outcome was the difference in speech recognition thresholds for 50% speech recognition (SRT50) in quiet between unaided preoperative and aided 12-month postactivation. Secondary outcomes included SRT50 in noise, sound-field thresholds, patient-reported outcomes, air- and bone-conduction thresholds, and adverse events.</p><p><strong>Results: </strong>Audiological outcomes were evaluated in 67 patients. SRT50 in quiet significantly improved across all subgroups, with large effect sizes (Cohen dz>0.8): 17.9±9.3 dB (LP), 18.3±8.4 dB (SP), 25.3±6.3 dB (RW), 23.1±17.6 dB (SH), and 21.6±9.4 dB in children. SRT50 in noise improved by 4.3 to 9.2 dB, and functional gains ranged from 18.3 to 39.2 dB. Patients reported positive impacts on quality of life and perceived quality of hearing. Two device explantations and 2 revision surgeries occurred. Exploratory analyses showed no statistically detectable differences between coupling approaches.</p><p><strong>Conclusion: </strong>AMEI use was associated with significant audiological and patient‑reported improvements in adults and children. Within the limitations of this observational study, including limited power and baseline heterogeneity, no statistically detectable differences in outcomes were observed between coupling approaches. Coupler selection should therefore remain guided by anatomic and clinical considerations.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Superior Semicircular Canal Roof Thickness With Age and Sex on Photon-counting Detector CT in a Japanese Cohort. 日本人群光子计数检测器CT上半规管顶板厚度与年龄和性别的关系。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 DOI: 10.1097/MAO.0000000000005036
Hiroshi Sakaida, Taishin Yamada, Yasutaka Ichikawa, Akio Yamazaki, Hirofumi Shibata
{"title":"Association of Superior Semicircular Canal Roof Thickness With Age and Sex on Photon-counting Detector CT in a Japanese Cohort.","authors":"Hiroshi Sakaida, Taishin Yamada, Yasutaka Ichikawa, Akio Yamazaki, Hirofumi Shibata","doi":"10.1097/MAO.0000000000005036","DOIUrl":"https://doi.org/10.1097/MAO.0000000000005036","url":null,"abstract":"<p><strong>Objective: </strong>To quantify superior semicircular canal (SSC) roof thickness using ultra-high-resolution photon-counting detector CT (PCD-CT) and to evaluate its cross-sectional association with age and sex.</p><p><strong>Study design: </strong>Retrospective cross-sectional study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>576 ears from 288 consecutive patients (mean age 42.7±27.3 y; range 0-89; 154 males, 134 females) undergoing clinically indicated temporal bone PCD-CT.</p><p><strong>Main outcome measure: </strong>Minimal SSC roof thickness on Pöschl-plane reconstructions (0.2 mm slice thickness), with intrarater and inter-rater reliability assessed.</p><p><strong>Results: </strong>Reliability was excellent (intrarater ICC 0.966; inter-rater ICC 0.939). A linear mixed-effects model in the full cohort revealed a significant age × sex interaction (B=0.004, P=0.016): females showed no cross-sectional age-related change (B=0.000 mm/year), while males showed a small positive association (B=0.004 mm/year; ∼0.04 mm/decade). In a prespecified pediatric subgroup (<20 years; 84 patients), males showed significant cross-sectional thickening (+0.031 mm/year, P=0.001) and a similar trend in females (+0.020 mm/year), and females had thicker SSC roofs than males (0.88 vs. 0.70 mm at 7.7 years; P=0.039). The interaction was nonsignificant within both the pediatric (P=0.431) and adult (P=0.204) subgroups separately, indicating that the full-cohort interaction likely reflects the developmental phase difference between childhood and adulthood.</p><p><strong>Conclusions: </strong>SSC roof thickness does not decrease with age during adulthood, while active cross-sectional thickening occurs during childhood, suggesting that bony coverage is largely established during the first two decades of life. Adult-onset SSCDS likely reflects the interaction between congenitally thin coverage and secondary factors-intracranial pressure dynamics, mechanical events, and biomechanical changes-rather than progressive resorption.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cultivating the Future of Otology & Neurotology. 培育耳神经科学的未来。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 Epub Date: 2026-07-23 DOI: 10.1097/MAO.0000000000005021
Matthew L Bush
{"title":"Cultivating the Future of Otology & Neurotology.","authors":"Matthew L Bush","doi":"10.1097/MAO.0000000000005021","DOIUrl":"10.1097/MAO.0000000000005021","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"937"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Management of Magnetic Interactions Between Ipsilateral Cochlear Implantation and Programmable Ventriculoperitoneal Shunts. 同侧人工耳蜗植入与可编程脑室-腹膜分流术磁相互作用的安全性和管理。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI: 10.1097/MAO.0000000000004951
Christian J Bernard, Prishae Wilson, Joseph Breen, Mallory Raymond
{"title":"Safety and Management of Magnetic Interactions Between Ipsilateral Cochlear Implantation and Programmable Ventriculoperitoneal Shunts.","authors":"Christian J Bernard, Prishae Wilson, Joseph Breen, Mallory Raymond","doi":"10.1097/MAO.0000000000004951","DOIUrl":"10.1097/MAO.0000000000004951","url":null,"abstract":"<p><strong>Objective: </strong>To describe 2 cases of ipsilateral programmable ventriculoperitoneal shunt placement and cochlear implantation, and provide recommendations on the specific risks and perioperative considerations related to magnetic interactions between devices.</p><p><strong>Patients: </strong>An 82 and 83-year-old male with a history of normal pressure hydrocephalus and 2 different types of programmable ventriculoperitoneal shunts, one of which was considered locking and the other non-locking.</p><p><strong>Intervention s: </strong>Ipsilateral cochlear implantation with and without preoperative ex vivo magnet interaction testing.</p><p><strong>Main outcome measures: </strong>Occurrence or non-occurrence of programmable ventriculoperitoneal shunt setting change secondary to cochlear implant magnetic interaction.</p><p><strong>Results: </strong>In case 1, the patient's non-locking valve setting was found to be significantly altered from baseline at 6 months postoperatively, prompting revision to a shunt with a locking mechanism, allowing resumption of cochlear implant use. In case 2, there was no interaction between the locking valve and cochlear implant observed during preoperative ex vivo device testing or through postoperative monitoring.</p><p><strong>Conclusions: </strong>Cochlear implantation in patients with programmable ventriculoperitoneal shunts is feasible but requires careful planning. In addition to avoiding direct magnetic overlap and verifying valve function before and after surgery, cochlear implant surgeons should consider avoiding ipsilateral cochlear implantation in the setting of a non-locking programmable ventriculoperitoneal shunt valve.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e984-e987"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Workplace Accommodations for Workers With Hearing Loss: A Scoping Review With Implications for the Health Setting. 听力损失工人的工作场所住宿:对健康环境影响的范围审查。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 Epub Date: 2026-05-26 DOI: 10.1097/MAO.0000000000004955
Geethanjeli Mahendran, Heather McClure, Deborah Goss, Stacey Gray, Alicia Quesnel, Jenny X Chen
{"title":"Workplace Accommodations for Workers With Hearing Loss: A Scoping Review With Implications for the Health Setting.","authors":"Geethanjeli Mahendran, Heather McClure, Deborah Goss, Stacey Gray, Alicia Quesnel, Jenny X Chen","doi":"10.1097/MAO.0000000000004955","DOIUrl":"10.1097/MAO.0000000000004955","url":null,"abstract":"<p><strong>Objectives: </strong>To highlight current workplace accommodation for workers with hearing loss (WHL) with specific emphasis on those in the health care sector. To identify how current accommodations can be used to improve the experiences of health care workers with hearing loss.</p><p><strong>Data sources: </strong>Four databases (Embase, Ovid Medline, Web of Science, and CINAHL Complete) were searched using keywords related to workplace accommodations for WHL.</p><p><strong>Methods: </strong>Inclusion and exclusion criteria were applied by 2 authors independently reviewing each article, while a third author resolved any discrepancies. Results were reported according to PRISMA-ScR guidelines.</p><p><strong>Results: </strong>Among the 393 publications identified in the database searches and 8 publications identified from manual bibliographic searches, 11 studies were included. All articles were cross-sectional surveys or qualitative studies. These articles included 714 WHL in a range of workplace settings. One hundred fifty-one (21.1%) and 43 (60.2%) of the WHL used personal assistive listening devices (PALD) and American Sign Language, respectively. Among the WHL, 254 (35.6%) were health care workers. The most common accommodation was the use of captioning technology and PALD. Among health care WHL, the use of amplified stethoscopes was the only specific accommodation reported. Additional accommodations desired among health care WHL included increased advocacy, financial assistance with PALD, improved technology and the routine use of transparent face masks.</p><p><strong>Conclusion: </strong>While several workplace accommodations have been implemented, there is still room for improvement. Improved accommodation tailored to the needs of health care WHL could improve retention, productivity, and patient safety.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e967-e972"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beta-2 Transferrin May Not Be Specific for Presence of Cerebrospinal Fluid in Middle Ear Fluid. β -2转铁蛋白可能对中耳液中脑脊液的存在没有特异性。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 Epub Date: 2026-05-19 DOI: 10.1097/MAO.0000000000004952
Anthony Thai, Sasa Vasilijic, Lindsay S Moore, Peter J Kullar, Jennifer Y Lee, Alan G Cheng, Douglas R Sidell, Grace S Kim, Tulio A Valdez, Kay W Chang, Iram N Ahmad, Karthik Balakrishnan, Konstantina M Stankovic, Jennifer C Alyono
{"title":"Beta-2 Transferrin May Not Be Specific for Presence of Cerebrospinal Fluid in Middle Ear Fluid.","authors":"Anthony Thai, Sasa Vasilijic, Lindsay S Moore, Peter J Kullar, Jennifer Y Lee, Alan G Cheng, Douglas R Sidell, Grace S Kim, Tulio A Valdez, Kay W Chang, Iram N Ahmad, Karthik Balakrishnan, Konstantina M Stankovic, Jennifer C Alyono","doi":"10.1097/MAO.0000000000004952","DOIUrl":"10.1097/MAO.0000000000004952","url":null,"abstract":"<p><strong>Objective: </strong>Quantify beta-2 transferrin (B2T)-positivity in the middle ear fluid of patients undergoing pressure equalization tube (PET) placement for recurrent acute otitis media (RAOM) or chronic otitis media with effusion (COME).</p><p><strong>Study design: </strong>Prospective.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Eighty-one ears from 60 patients undergoing PET placement. Mean age was 12.1 years. Forty-three ears (60.6% of ears) were male. Forty-five ears (63.4%) had COME. Mean effusion duration was 6.2 months.</p><p><strong>Interventions: </strong>PET placement. B2T was measured in middle ear aspirates using quantitative ELISA. Ten ears were excluded due to coefficients of variance >20% between duplicate wells, likely from sample viscosity.</p><p><strong>Main outcome measures: </strong>B2T-positivity rate and quantitative levels.</p><p><strong>Results: </strong>Of 71 ears, 55 (77.5%) were B2T-positive. Compared with B2T-negative ears, B2T-positive ears were more likely to be younger (6.1 vs. 32.9 y, P =0.004), have mucoid effusion (70.9% vs. 20.0%, P =0.001), and have RAOM (45.6% vs. 12.5%, P =0.02). Fifty-three of 61 pediatric ears (86.9%) were B2T-positive, compared with 2 of 10 adult ears (20%). B2T-positivity was not associated with gender, effusion duration, or color of aspirate. No patients had chronic otorrhea after PET placement.</p><p><strong>Conclusions: </strong>Although B2T is considered the gold standard to detect cerebrospinal fluid (CSF), our study shows high B2T positivity rates in the middle ear fluid of patients undergoing PET placement for RAOM or COME. B2T may not be specific for CSF leak into the middle ear. Clinicians should exercise caution when interpreting results of B2T testing, particularly in the pediatric population and those with mucoid effusions.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"1044-1049"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Determinants of Health and Impact on Cochlear Implant Performance. 健康的社会决定因素及其对人工耳蜗植入性能的影响。
IF 1.7 3区 医学
Otology & Neurotology Pub Date : 2026-09-01 Epub Date: 2026-06-16 DOI: 10.1097/MAO.0000000000004979
James W Bao, Sabina Dang, Karmela Dizdar, Dorina Kallogjeri, Cole Pavelchek, Mona Jawad, David Lee, Jordan Varghese, Amit Walia, Stephanie Youssef, Katelyn A Berg, Nedim Durakovic, Pawina Jiramongkolchai, Jay F Piccirillo, Jacques A Herzog, Craig A Buchman, Matthew A Shew
{"title":"Social Determinants of Health and Impact on Cochlear Implant Performance.","authors":"James W Bao, Sabina Dang, Karmela Dizdar, Dorina Kallogjeri, Cole Pavelchek, Mona Jawad, David Lee, Jordan Varghese, Amit Walia, Stephanie Youssef, Katelyn A Berg, Nedim Durakovic, Pawina Jiramongkolchai, Jay F Piccirillo, Jacques A Herzog, Craig A Buchman, Matthew A Shew","doi":"10.1097/MAO.0000000000004979","DOIUrl":"10.1097/MAO.0000000000004979","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association of social determinants of health (SDH) on postoperative speech perception outcomes in adult CI recipients.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>Tertiary academic center.</p><p><strong>Patients: </strong>Four hundred forty-seven post-lingually deafened adult CI recipients.</p><p><strong>Intervention: </strong>Cochlear implantation.</p><p><strong>Main outcome measures: </strong>The national Area Deprivation Index (ADI) is a ranking of neighborhood socioeconomic disadvantage with higher ADI suggesting greater disadvantage. The primary outcome was the change in ipsilateral CNC scores (delta CNC) at 3 months compared with pre-implant. Multivariable linear regression was used to explore the association of SDH factors on delta CNC scores at 3 months while controlling for confounders.</p><p><strong>Results: </strong>The mean (SD) ADI of patients in this study was 54.6 (23.9). CNC scores at 3 months increased by a mean (SD) of 31.5% (25.7%). In multivariable regression models, there was a significant interaction effect between national ADI and insurance type on delta CNC. After controlling for age and preoperative pure-tone average (PTA), for patients with Medicare insurance, every additional point increase in ADI is associated with 0.08% decrease in delta CNC. For patients with commercial insurance, every additional point increase in ADI is associated with 0.12% increase in delta CNC.</p><p><strong>Conclusions: </strong>National ADI is a well-established measure for SDH and should be explored to better understand equitable CI health care. In patients with Medicare, there was a significant association between higher ADI and smaller delta in CNC speech perception scores. This association of SDH and CI outcomes raises critical questions that need to be explored through larger, more diverse studies to better advance equitable hearing health care.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"971-977"},"PeriodicalIF":1.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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