Otology & Neurotology最新文献

Bacteriophage Therapy for Chronic Mastoiditis.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-01-22 DOI: 10.1097/MAO.0000000000004417

Julia Casazza, Donald Tan, Mark Newcomer, Hitomi Sakano, Brandon Isaacson, Jacob B Hunter

引用次数: 0

Characterization of the Expression and Role of Striatin-Interacting Protein 2 in Mouse Cochlea.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004449

Siyu Li, Yue Qiu, Ao Li, Jie Lu, Xinya Ji, Wenli Hao, Cheng Cheng, Xia Gao

{"title":"Characterization of the Expression and Role of Striatin-Interacting Protein 2 in Mouse Cochlea.","authors":"Siyu Li, Yue Qiu, Ao Li, Jie Lu, Xinya Ji, Wenli Hao, Cheng Cheng, Xia Gao","doi":"10.1097/MAO.0000000000004449","DOIUrl":"10.1097/MAO.0000000000004449","url":null,"abstract":"Hypothesis: In this study, we aimed to examine the cochlear expression pattern and function of Striatin-interacting protein 2 (STRIP2) by using animal models.Background: Sensorineural hearing loss often results from genetic defects in hair cell (HC) development and function. STRIP2 is a part of the striatin-interacting phosphatase and kinase (STRIPAK) complex, which plays important regulatory roles in cell fate determination, proliferation, cytoskeletal organization, and cell morphology. A recent study revealed Strip2 as the candidate gene that regulates positive selection in HC lineages. However, its role in the inner ear has not been identified.Methods: Strip2 knockout mouse model was used to examine the cochlear expression pattern and function of STRIP2. Auditory brainstem response test was used to evaluate the hearing function of mice. Immunostaining and scanning electron microscope were used to study hair cells, synapses, and stereocilia of cochlea.Results: Immunostaining showed that cytoplasmic STRIP2 expression in hair cells increased from postnatal day (P) 3 to P14. Despite having normal hearing thresholds, hair cell numbers, and stereocilia morphology until P90, the deletion of Strip2 resulted in a mild reduction in ribbon synapse density, suggesting a late onset of cochlear synaptic defects.Conclusion: Our results revealed that STRIP2 was abundantly expressed in hair cells; however, the hearing function of Strip2-/- mice was comparable to that of control mice until P90, and a mild decrease in ribbon synapse number was detected at P60 and P90. Further studies on STRIP2 and its associated complexes will provide new insights into the pathways involved in inner ear development and function.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e139-e146"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Speech Outcomes of Cochlear Implantation, from 1983 to Present: A Systematic Review.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-28 DOI: 10.1097/MAO.0000000000004468

Nia S Brown, Sanjena Venkatesh, Tazheh A Kavoosi, James O Onyeukwu, Jason A Brant, Alexandra E Quimby

{"title":"Speech Outcomes of Cochlear Implantation, from 1983 to Present: A Systematic Review.","authors":"Nia S Brown, Sanjena Venkatesh, Tazheh A Kavoosi, James O Onyeukwu, Jason A Brant, Alexandra E Quimby","doi":"10.1097/MAO.0000000000004468","DOIUrl":"10.1097/MAO.0000000000004468","url":null,"abstract":"Objective: We sought to assess whether the totality of advancements seen in cochlear implant (CI) design and implementation have translated to significant improvements in speech perception scores.Databases reviewed: EMBASE, PubMed/MEDLINE, and the Cochrane Central Register of Controlled Trials.Methods: A systematic review of all English-language studies in peer-reviewed journals from 1946 to August 2022 was performed based on the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies were of adult patients who underwent cochlear implantation with Cochlear®, Med-EL, or Advanced Bionics devices with 12 months postoperative sentence recognition testing results. Meta-regression was performed to assess the relationship between speech recognition score and year of implantation. Preimplantation score and unilateral versus bilateral implantation were adjusted for. Subgroup analysis was performed by restricting to studies of <5 years duration and in which outcomes were measured ≤12 months postoperatively to reduce the likelihood of patients with remotely implanted devices having undergone upgrades to more contemporary coding software.Results: A total of 37 studies met criteria for inclusion, representing CIs implanted between 1983 and 2019. No significant association was identified between median study year and scores on 12-month postoperative sentence recognition testing on any of AzBio in quiet, CNC words, or HINT sentences in quiet. Subgroup analysis showed no difference in outcomes across 15 studies including patients implanted from 2007 to 2019.Conclusion: In the absence of improved CI coding strategies since 2007, speech recognition outcomes in quiet have also not improved significantly since this time.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 4","pages":"393-404"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Osseointegrated Transcutaneous Bone Conduction Implant: Results of a New Surgical Location in Children with Microtia and External Auditory Canal Atresia.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1097/MAO.0000000000004457

Carolina Der, Nicolás Pons, Sofia Bravo-Torres, Magdalena Cornejo

{"title":"Active Osseointegrated Transcutaneous Bone Conduction Implant: Results of a New Surgical Location in Children with Microtia and External Auditory Canal Atresia.","authors":"Carolina Der, Nicolás Pons, Sofia Bravo-Torres, Magdalena Cornejo","doi":"10.1097/MAO.0000000000004457","DOIUrl":"10.1097/MAO.0000000000004457","url":null,"abstract":"Objective: To present a different location, lateral to the middle fossa, as a new surgical alternative for an active transcutaneous bone conduction implant (ATBCI) in children with microtia and external auditory canal atresia (EACA) who cannot undergo traditional surgery due to altered anatomy or desire for future aesthetic reconstruction.Study design: Prospective, longitudinal, descriptive study. The surgical technique was developed. Preoperative and postoperative information was analyzed.Setting: Tertiary pediatric hospital in Santiago, Chile.Patients: Eight children with unilateral EACA and microtia.Intervention: ATBCI lateral to the middle fossa.Main outcome measure: Surgical, audiological, and quality-of-life outcomes.Result: Eight children with EACA were implanted. Surgery was uneventful except for one seroma. This placement is lateral to the middle fossa, serving as a location marker. Their average age was 13 years old. The average follow-up was 21 months. All patients had conductive hearing loss. The audiological and quality-of-life results were as expected for this device.Conclusions: This location for the ATBCI was proven to be safe and effective for treating pediatric patients with EACA who desire future aesthetic reconstruction. This new surgical technique is safe and faster than the one suggested by the manufacturer due to the flat bone in this region of the skull. The outcomes are comparable to those obtained with the traditional location described for this device.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 4","pages":"425-431"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remote Care: The Future of Cochlear Implants.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAO.0000000000004432

Meredith A Holcomb, Jennifer Coto, Tina Stern, Christina M Sarangoulis, Ivette Cejas, Chrisanda M Sanchez

{"title":"Remote Care: The Future of Cochlear Implants.","authors":"Meredith A Holcomb, Jennifer Coto, Tina Stern, Christina M Sarangoulis, Ivette Cejas, Chrisanda M Sanchez","doi":"10.1097/MAO.0000000000004432","DOIUrl":"10.1097/MAO.0000000000004432","url":null,"abstract":"Objective: The aims of this study were to 1) evaluate whether remote cochlear implant (CI) programming has comparable outcomes to traditional in-person CI management, 1) determine the effects of remote programming on family burden and associated costs, and 1) demonstrate feasibility and satisfaction of remote programming by patients and families for both the adult and pediatric CI populations.Study design: Prospective study of one CI program.Patients and intervention: Adult and pediatric patients with at least one CI underwent CI programming via in-person and remote visits.Main outcome measures: CI programming parameters (impedances, neural response telemetry, upper and lower stimulation levels, datalogging), technology comfort self-report, visit burden and satisfaction, mental health and quality of life.Results: Fifteen pediatric participants (mean age: 4.17 yr; SD = 3.24) and 15 adult participants (mean age: 56.73 yr; SD = 21.11) were enrolled. In-person and remote programming sessions yielded comparable results for measuring CI programming parameters. Adult and parent participants were highly satisfied with remote programming and reported receiving excellent care. Listening effort was significantly less for the remote visit as compared to the in-person visit for adults. Burden of care to attend the in-person visit was greater for the pediatric population in terms of expenses incurred, unpaid time off work, and coordination of care for other children.Conclusions: Remote programming is a feasible and effective service delivery model for the adult and pediatric CI population. Inclusion of remote services into postoperative CI protocols should be considered as a means of reducing barriers to hearing healthcare.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"372-380"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Osseointegrated Steady-State Implant System: Surgical and Clinical Performance.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-19 DOI: 10.1097/MAO.0000000000004453

Leornardo Ordoñez-Ordoñez, José Agustin Caraballo, Jorge Guillermo Cabrera Ortiz, Francisco Gonzalez Eslait, Rafael Jaramillo Saffon, José Gabriel Lora, Santiago Hernandez, Jose Guzman, Luz Adriana Rincon, Byanka Cagnacci Buzo

{"title":"Active Osseointegrated Steady-State Implant System: Surgical and Clinical Performance.","authors":"Leornardo Ordoñez-Ordoñez, José Agustin Caraballo, Jorge Guillermo Cabrera Ortiz, Francisco Gonzalez Eslait, Rafael Jaramillo Saffon, José Gabriel Lora, Santiago Hernandez, Jose Guzman, Luz Adriana Rincon, Byanka Cagnacci Buzo","doi":"10.1097/MAO.0000000000004453","DOIUrl":"10.1097/MAO.0000000000004453","url":null,"abstract":"Purpose: We aimed to investigate the surgical outcomes and clinical performance of an active osseointegration implant system that uses piezoelectric technology.Methods: This national, multicenter, prospective, repeated measures study was approved by the Ethics Committee (opinion no. CEISH 0559-2019). The sample included patients with conductive hearing loss (CHL), mixed hearing loss (MHL), or single-sided deafness (SSD) who were eligible for osseointegrated implant surgery. Surgical parameters were assessed, along with functional and effective gain (FG and EG) and self-perception of benefits, which were evaluated between 3 and 6 months after activation. Participants also completed the Client Oriented Scale of Improvement (COSI) questionnaire to subjectively report expected and perceived benefits.Results: A total of 580 participants aged 5 to 73 years were included in the study between June 2020 and April 2023. Most participants were diagnosed with CHL (58.8%), followed by MHL (28.8%) and SSD. 11.4% of the surgeries involved conversion of other devices to the piezoelectric system. The mean surgery duration was 54 min, and the mean skin thickness was 5.6 mm. Soft tissue reduction was required for 4% of the participants, while 21.2% required bone polishing. The mean PTA (pure tone average) FG was 38.6 dB for participants with CHL, 44.4 dB for those with MHL, and 66.1 dB for those with SSD.Conclusion: These results confirmed the clinical safety, performance, and benefits of an innovative active transcutaneous bone conduction implant with a piezoelectric transducer design for patients with CHL, MHL, or SSD.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e109-e116"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1097/MAO.0000000000004463

Per Cayé-Thomasen, Peter Erfurt, Peter Baumhoff, Andrej Kral, Charlotte Amalie Navntoft

{"title":"Surgical Transcanal Procedure for Injection of Cells and Substances into the Human Cochlear Modiolus.","authors":"Per Cayé-Thomasen, Peter Erfurt, Peter Baumhoff, Andrej Kral, Charlotte Amalie Navntoft","doi":"10.1097/MAO.0000000000004463","DOIUrl":"10.1097/MAO.0000000000004463","url":null,"abstract":"Introduction: Cochlear implants (CIs) enhance hearing by stimulating spiral ganglion neurons (SGNs) but are less effective in individuals with compromised SGN functionality. Advances in regenerative medicine suggest that local delivery of medical drugs or cell therapy could regenerate the auditory nerve. This study evaluates a minimally invasive technique for precise delivery of cell-sized beads, simulating cell therapy, into the cochlear modiolus of human temporal bones.Methods: Ten fresh-frozen human temporal bone specimens were used. Five bones served to establish the injection trajectory using a tungsten rod probe, and the remaining five for injecting microbeads into the modiolus. The surgical procedure involved accessing the middle ear via the external ear canal, performing a cochleostomy at the first cochlear turn, and drilling into the modiolus. Beads were injected into the modiolus using a Hamilton syringe connected to an injection pump, followed by micro-computed tomography imaging and histological assessment.Results: Accurate placement of the tungsten rod probe within the modiolus was achieved in four out of five bones. Microbead injections indicated 89 to 97% retention within the modiolus, with minimal leakage. The technique showed consistent trajectory with low variability.Conclusion: The study demonstrates the feasibility of a minimally invasive, precise injection method for delivering and retaining cell-sized beads into the cochlear modiolus. This technique enables future local delivery of medical drugs or cell therapy drugs aimed at hearing restoration, benefiting both current CI users and CI candidates. Further research is necessary to evaluate precision, reproducibility, and long-term outcomes of the procedure.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"476-484"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11939087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Benefits of Behind-the-Ear Processors Compared With Off-the-Ear Processors in Adult Cochlear Implant Users.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004430

Craig D Salvador, Zachary Sinacori, Elizabeth L Camposeo, Ted A Meyer, Theodore R McRackan

{"title":"Functional Benefits of Behind-the-Ear Processors Compared With Off-the-Ear Processors in Adult Cochlear Implant Users.","authors":"Craig D Salvador, Zachary Sinacori, Elizabeth L Camposeo, Ted A Meyer, Theodore R McRackan","doi":"10.1097/MAO.0000000000004430","DOIUrl":"10.1097/MAO.0000000000004430","url":null,"abstract":"Objective: Cochlear implant (CI) devices are fitted with two external processor styles-a behind-the-ear (BTE) or an off-the-ear (OTE) option. Although previous research has predominantly focused on speech recognition abilities between processor styles, the current study aims to examine the potential real-world functional differences between processor types.Study design: Retrospective case-control, matched at a 1:2 ratio.Setting: Tertiary Otolaryngology Referral Center.Patients: Patients with bilateral sensorineural hearing loss.Intervention: Cochlear implantation.Main outcome measures: Cochlear Implant Quality of Life 35 Profile (CIQOL-35 Profile), and CNC word (CNCw) and AzBio sentence (quiet) recognition.Results: A total of 36 patients were included (n = 12 OTE and n = 24 BTE users). The overall study population demonstrated improvements in CNCw ( d = 1.9 [1.3, 2.4]), AzBio sentences in quiet ( d = 2.1 [1.5, 2.6]), and medium-to-large effect sizes for domains of the CIQOL-35 ( d range: 0.5-0.9) after cochlear implantation. Between-group analysis demonstrated that BTE users performed better in CNCw ( d = 0.4 [-0.3, 1.1]) and AzBio quiet ( d = 0.5 [-0.2, 1.2]) than their OTE counterparts. However, there were minimal differences identified between processor types based on CIQOL domain and global scores ( d range: 0.04-0.2).Conclusion: BTE users may have a better speech recognition ability than their OTE counterparts. However, CIQOL domain and global scores are comparable between the two processor types. A prospective, randomized controlled trial will be needed to address the limitations of a retrospective analysis.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"358-363"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of Pneumatization of Parts of Temporal Bone in High-Resolution Computed Tomography and Its Implications.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/MAO.0000000000004440

Reshma Eugine, Abhishek Bhardwaj, Manu Malhotra, Madhu Priya, Sudhir Saxena, Ankita Semwal, G Vetrivel, Anil Kumar

{"title":"Patterns of Pneumatization of Parts of Temporal Bone in High-Resolution Computed Tomography and Its Implications.","authors":"Reshma Eugine, Abhishek Bhardwaj, Manu Malhotra, Madhu Priya, Sudhir Saxena, Ankita Semwal, G Vetrivel, Anil Kumar","doi":"10.1097/MAO.0000000000004440","DOIUrl":"10.1097/MAO.0000000000004440","url":null,"abstract":"Objective: Investigate the pneumatization pattern of parts of the temporal bone in high-resolution computed tomography (HRCT) and their associations with age, gender, and squamous chronic otitis media (COM) in the contralateral ear. To investigate the symmetry of pneumatization and correlations between pneumatization patterns of parts of the temporal bone.Study design: Prospective study.Setting: Tertiary care center.Patients: Two hundred sixty patients who underwent HRCT temporal bone.Interventions and main outcome measures: Evaluation of pneumatization of mastoid and petrous apex as per Han et al. and infralabyrinthine as per Marchioni et al. classification.Results: The commonest pneumatization patterns were group 4 (32.8%), group 1 (69.7%), and type C (76%) for mastoid, petrous apex, and infralabyrinthine parts, respectively. Group 4 pneumatization of the petrous apex ( w = 0.487) and type A infralabyrinthine pneumatization ( w = 0.315) were significantly associated with group 4 mastoid pneumatization ( p < 0.001) but not vice versa. Significant association was observed between age and pattern of mastoid pneumatization ( w = 0.25; p = 0.002) but not for other parts. No significant gender difference was observed in the temporal bone's pneumatization pattern. A significant symmetry was seen in the pneumatization of two ears for all parts. COM in the contralateral ear was significantly associated with group 3 mastoid pneumatization ( w = 0.16; p = 0.036).Conclusion: Mastoid shows hyperpneumatization, and other parts show absent pneumatization as commonest pattern, with only one-way correlation between increased pneumatization of other parts and mastoid. COM in the contralateral ear and age show a significant association with the type of mastoid pneumatization, but not other parts.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"405-412"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotics Use Practices in Otology Procedures: A Nationwide Survey Study.

IF 1.9 3区医学

Otology & Neurotology Pub Date : 2025-04-01 Epub Date: 2025-02-14 DOI: 10.1097/MAO.0000000000004448

Azmi Marouf, Samya Konda, De'Andre Warren, Claudia I Cabrera, Sarah Mowry, Alejandro Rivas, Maroun Semaan, Daniel E Killeen

{"title":"Antibiotics Use Practices in Otology Procedures: A Nationwide Survey Study.","authors":"Azmi Marouf, Samya Konda, De'Andre Warren, Claudia I Cabrera, Sarah Mowry, Alejandro Rivas, Maroun Semaan, Daniel E Killeen","doi":"10.1097/MAO.0000000000004448","DOIUrl":"10.1097/MAO.0000000000004448","url":null,"abstract":"Objective: To assess practice patterns regarding antibiotics prophylaxis in otologic surgery in the United States.Study design: Cross-sectional study.Setting: Tertiary care center.Subjects: Members of American Neurotology Society (ANS).Intervention: Nationwide survey.Main outcome measures: Prevalence of antibiotic prescribing among surgeons performing the following six ear surgical procedures: cochlear implantation, tympanoplasty with a clean ear, tympanoplasty with active drainage, cholesteatoma surgery without evidence of infection, cholesteatoma surgery with evidence of infection, and stapedectomy.Results: Seventy-three surgeons completed the survey (15.21% response rate). Twenty-seven percent had more than 25 years in experience, and 18% had 0 to 5 years of experience. Antibiotic prescribing practices varied by procedure: cochlear implantation (64.4%, median 5 d), tympanoplasty (clean ear: 23.3%, median 5 d; active drainage: 53.4%, median 7 d), cholesteatoma surgery (no infection: 30.1%, median 7 d; with infection: 58.9%, median 7 d), and stapedectomy (34.2%, mean 5 d). Cephalosporins were preferred for noninfected procedures, whereas amoxicillin dominated for active infections.Conclusions: Prophylactic oral antibiotics varies for ear surgery, with higher usage for procedures with active infection and a preference for cephalosporins in noninfected cases. These findings underscore the need for the development and dissemination of standardized, evidence-based recommendations.","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"470-475"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0