Otology & Neurotology最新文献

{"title":"A Systematic Review of the Incidence of Cochlear Nerve Deficiency in Pediatric Single-Sided Deafness.","authors":"Christina Zhu, Jasmine Gulati, Daniel Swanson, Anuja Shah, Paul Chisolm, Michael Hoa","doi":"10.1097/MAO.0000000000004474","DOIUrl":"10.1097/MAO.0000000000004474","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the variability in cochlear nerve deficiency (CND) incidence in pediatric single-sided deafness (SSD), assess how study parameters and inclusion criteria affect these rates, and examine the diagnostic tools utilized, including magnetic resonance imaging (MRI) and computed tomography (CT), in identifying CND.</p><p><strong>Data sources: </strong>Databases including MEDLINE, Embase, Cochrane CENTRAL, and Web of Science.</p><p><strong>Review methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines with predefined search criteria using terms related to pediatric unilateral hearing loss and CND from 2010 to January 2024. Studies were selected based on their focus on CND incidence in pediatric SSD, excluding case reports, nonhuman or adult studies, and analyses limited to bilateral deafness.</p><p><strong>Results: </strong>Out of 518 articles screened, 17 underwent full-text review, and 10 were included. Incidence rates of CND ranged from 15.7% to 100%, with all studies using MRI and 60% using CT as an adjunct diagnostic tool. Age criteria varied: five studies included patients 18 years and older, one study included patients up to age 21 years, and four studies targeted children under 5 years, including two studies on neonates. Variability stemmed from differing inclusion criteria; studies on younger cohorts generally excluded noncongenital causes, while older children's studies were less restrictive. Additionally, two studies excluded syndromic SSD, impacting incidence rates. Larger studies show an overall incidence of 35% to 45%, which this systematic review of the literature reports as the approximate incidence of CND in SSD, with higher incidence rates observed in studies excluding syndromic causes and broader criteria linked to decreased incidence.</p><p><strong>Conclusion: </strong>This systematic review highlights how age-specific inclusion criteria and management of syndromic causes significantly influence reported CND incidence rates in pediatric SSD, underscoring the need for standardized reporting to improve clinical understanding and treatment approaches.Level of Evidence: 1.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"668-674"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image Quality Improvement in MRI of Cochlear Implants and Auditory Brainstem Implants After Metal Artifact Reduction Techniques.","authors":"Arianna Winchester, Justin Cottrell, Emily Kay-Rivest, David Friedmann, Sean McMenomey, J Thomas Roland, Mary Bruno, Mari Hagiwara, Gul Moonis, Daniel Jethanamest","doi":"10.1097/MAO.0000000000004517","DOIUrl":"10.1097/MAO.0000000000004517","url":null,"abstract":"<p><strong>Objective: </strong>Observe if metal artifact reduction (MAR) techniques applied to magnetic resonance imaging (MRI) performed on patients with cochlear implants (CI) or auditory brainstem implants (ABI) improves image quality.</p><p><strong>Study design: </strong>Retrospective review.</p><p><strong>Setting: </strong>Tertiary care center.</p><p><strong>Patients: </strong>Patients with auditory implants who underwent clinical MRI before and after the application of MAR techniques previously described.</p><p><strong>Interventions: </strong>From September 2022 to March 2023, patients who underwent brain or internal auditory canal (IAC) MRI with and without MAR were identified. Sequences included T1 and T2 weighted with turbo-spin-echo (TSE) correction and fluid-attenuation inversion recovery (FLAIR). Images were analyzed for visualization of intracranial structures by two neuroradiologists.</p><p><strong>Main outcome measures: </strong>Visibility of 14 structures graded on a four-point Likert scale. Average scores per structure and sequence were compared using paired two-tailed t -tests and change in mode score.</p><p><strong>Results: </strong>Ten patients underwent pre- and post-MAR MRI. Six had a unilateral CI, three had a unilateral ABI, and one had an ABI and CI. Three patients had four devices with the internal magnet removed for both scans. All structures had significantly improved visibility on post-MAR scan except ipsilateral parietal and occipital lobes and contralateral inner ear. Mode score increased from 2 to 4 for the ipsilateral occipital lobe and from 3 to 4 for the ipsilateral semicircular canals, brainstem, and cerebellar peduncles. Significant improvement was seen in all sequences except for ipsilateral structures on T1w axial precontrast and contralateral structures on T1w coronal postcontrast. ABIs did not improve as much as CIs because they scored better on the pre-MAR scan.</p><p><strong>Conclusions: </strong>MAR techniques improve image quality for patients with MRI-compatible implants with magnets. Benefits may be more evident in CIs than ABIs.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"641-647"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ménière's Disease With a Prior Diagnosis of Idiopathic Sudden Hearing Loss.","authors":"Minerva Rodriguez-Martín, Rocío González-Aguado, Trinidad Dierssen Sotos, Carmelo Morales-Angulo","doi":"10.1097/MAO.0000000000004508","DOIUrl":"10.1097/MAO.0000000000004508","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to determine the percentage of patients with idiopathic sudden hearing loss later diagnosed with Ménière's disease. It also seeks to identify predictive factors for Ménière's diagnosis and compare treatment responses between first-time Ménière's patients and those with idiopathic sudden hearing loss.</p><p><strong>Study design: </strong>A prospective observational study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Patients: </strong>Cohort of apparently idiopathic sudden hearing loss patients over a period of 30 years (1992-2022).</p><p><strong>Intervention: </strong>Identification of Ménière's disease cases during follow-up.</p><p><strong>Main outcome measure: </strong>Determining how many were subsequently diagnosed with definitive Ménière's disease.</p><p><strong>Results: </strong>From a cohort of 369 patients with apparently idiopathic sudden hearing loss treated over 30 years, 15 (4%) developed definite Ménière's disease.The predictive factors for developing Ménière's disease were mild to moderate hearing loss, vertigo, tinnitus at the initial episode, and a predominantly ascending audiometric curve.When comparing treatment responses, patients with Ménière's disease showed better outcomes than those with idiopathic sudden hearing loss.</p><p><strong>Conclusions: </strong>Cases of sudden sensorineural hearing loss that represent the first episode of definite Ménière's disease are rare. A moderate hearing loss at low frequencies, accompanied by tinnitus and vertigo during an episode of sudden hearing loss, should raise suspicion for Ménière's disease rather than idiopathic sudden hearing loss. Patients with sudden hearing loss secondary to an episode of Ménière's disease tend to show significantly greater hearing improvement compared with those with idiopathic sudden hearing loss.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"680-685"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and Specificity of Intraoperative TransImpedance Matrix Recordings Compared With X-ray Imaging in Detecting Perimodiolar Cochlear Implant Tip Foldovers: A Multicenter Study.","authors":"Alexandra M Arambula, Robin Piper, Gail Murray, Sarah E Mowry, Alejandro Rivas, Maroun Semaan, Nauman F Manzoor, Daniel E Killeen, David C Kelsall, J Eric Lupo, Allison Biever, Katrina R Stidham, Regina Albinus, Samantha Morgan, Brian J Kaplan, Regina Presley, Sarah Menendez, Viral D Tejani","doi":"10.1097/MAO.0000000000004502","DOIUrl":"10.1097/MAO.0000000000004502","url":null,"abstract":"<p><strong>Objective: </strong>Characterize the sensitivity and specificity of TransImpedance Matrix (TIM) recordings compared with x-rays in detecting cochlear implant tip foldovers.</p><p><strong>Study design: </strong>Retrospective.</p><p><strong>Setting: </strong>Multi-institutional, academic and private surgery centers.</p><p><strong>Patients: </strong>Patients 6 months and older undergoing cochlear implantation.</p><p><strong>Interventions: </strong>After cochlear implant array insertion, intraoperative TIM recordings and x-rays were conducted to confirm appropriate placement. If a foldover was identified, repeat insertion, followed by TIM and x-ray, was performed.</p><p><strong>Main outcome measures: </strong>Presence of tip foldovers as determined by TIM recordings and x-rays.</p><p><strong>Results: </strong>There were 13 tip foldovers out of 484 insertions, yielding a 2.7% tip foldover rate. Using x-rays as the \"gold standard,\" TIM recordings showed 100% sensitivity, 99.6% specificity, 84.6% positive predictive value (PPV), and 100% negative predicative value in detecting tip foldovers. The x-ray images for two TIM-identified tip foldovers were interpreted as normal intraoperatively (apparent false positives), but then were interpreted as foldovers when presented to the operating surgeon postoperatively in a blinded fashion. If these false positives had been reclassified as true positives, TIM specificity and PPV would both improve to 100%.</p><p><strong>Conclusions: </strong>These results provide further support regarding the utility of TIM recordings to evaluate appropriate cochlear implant electrode array position. Despite the low tip foldover rate reported across the literature and within this study, this multicenter patient group provided a large sample size to calculate the sensitivity and specificity of TIM recordings in identifying tip foldovers. Compared with the reference-standard, x-ray imaging, TIM recordings show equivalent, and in some cases superior, performance in identification of tip foldovers. Thus, use of TIM can potentially preclude the need for routine intraoperative x-rays without compromising patient care.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"627-633"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-Assessing the Interpretation of Beta Trace Protein Levels in Middle Ear Fluid in the Assessment for Lateral Skull Base Cerebrospinal Fluid Leaks.","authors":"Katherine Pollaers, John Joseph, Ee Mun Lim, Jafri Kuthubutheen, Stephen Rodrigues","doi":"10.1097/MAO.0000000000004475","DOIUrl":"10.1097/MAO.0000000000004475","url":null,"abstract":"<p><strong>Hypothesis: </strong>Describe the range of values of BTP obtained in middle ear fluid samples and determine if the level of BTP is a reliable indicator of the presence of a cerebrospinal fluid middle ear effusion.</p><p><strong>Background: </strong>Beta trace protein is a glycoprotein abundant in the CSF. Middle ear fluid samples are tested for the presence of BTP, which provides a numerical representation of the concentration of CSF. A middle ear fluid sample deemed to be positive for CSF has a BTP level of greater than 1.3 mg/L. However, this level is not specific to the middle ear, and there is a paucity of literature regarding interpretation of the BTP level when used in the evaluation for suspected lateral temporal bone CSF leaks.</p><p><strong>Methods: </strong>Retrospective review of all middle and nasal fluid samples sent by otolaryngologists for beta trace protein testing in Western Australia over a 4-year period.</p><p><strong>Results: </strong>A total of 168 patients had a middle ear fluid sample sent for BTP testing; these samples were obtained via tympanocentesis through an intact tympanic membrane with no other ear or temporal bone pathology. Ninety-six (96%) of the middle ear samples (172 of 178) had a BTP level greater than 1.3 mg/L, indicating a positive result and suggesting the presence of cerebrospinal fluid within the sample.</p><p><strong>Conclusion: </strong>The BTP level of middle ear fluid aspirates should be viewed with caution and used in conjunction with radiological findings and clinical impressions in the formulation of a management plan in patients suspected of lateral skull base CSF leaks.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"700-705"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evidence on the Influence of Implant Position onto Maximum Output with the Bonebridge Bone Conduction Implant.","authors":"Daniel Schurzig, Rebecca Iseke, Hannes Maier, Nils Kristian Prenzler, Thomas Lenarz, Mohammad Ghoncheh","doi":"10.1097/MAO.0000000000004533","DOIUrl":"10.1097/MAO.0000000000004533","url":null,"abstract":"<p><strong>Hypothesis: </strong>In bone conduction implantation, the position of the implant influences the audiological benefit of the patient.</p><p><strong>Background: </strong>One way of treating hearing loss is the implantation of bone conduction implants (BCIs), which effectively transmit vibrations through the skull bone to the cochlea given that the implant transducer is securely fixated. Laboratory research on the efficacy of bone conduction sound transmission found that a closer proximity of the transducer to the ipsilateral cochlea yields significantly higher cochlear promontory vibrations and hence, higher stimulation efficacy. Up to now, this finding has not been reproduced using clinical data such as the functional or effective gain.</p><p><strong>Methods: </strong>The present, retrospective study was conducted on a cohort of 28 BCI patients to correlate the implantation site of the BC transducer, derived from clinical postoperative imaging and defined in a standardized coordinate system, with maximum output values that are exclusively based on a novel calculation method only employing clinical audiological data.</p><p><strong>Results: </strong>It could be shown that the efficacy of BCI stimulation is in fact correlated with the transducer distance to the cochlea, and that this correlation is frequency dependent. Furthermore, the longitudinal distance of the transducer and the ipsilateral external auditory canal is negatively correlated with the maximal output while the sagittal distance is not.</p><p><strong>Conclusion: </strong>The present study is hence the first one to clinically demonstrate the significance of BCI placement for maximizing patient benefit, which should be considered during the preoperative planning of bone conduction implantation.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"725-732"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Diagnostic Accuracy of the Side-Lying Test for Posterior Canal BPPV: Sensitivity and Specificity Analysis.","authors":"Neetu Rani Dhiman, Dharma Raj, Vyom Gyanpuri, Anand Kumar, Varun Kumar Singh, Abhishek Pathak, Rameshwar Nath Chaurasia, Vijay Nath Mishra, Deepika Joshi","doi":"10.1097/MAO.0000000000004505","DOIUrl":"10.1097/MAO.0000000000004505","url":null,"abstract":"<p><strong>Background objective: </strong>The side-lying (SL) test is a diagnostic maneuver used to identify posterior canal benign paroxysmal positional vertigo (PC-BPPV). It is often used as an alternative to the Dix-Hallpike (DH) test, particularly for patients who have mobility limitations. The objective of this study is to evaluate the sensitivity and specificity of the SL test in diagnosing PC-BPPV compared with the DH test.</p><p><strong>Methods: </strong>A cohort of 320 patients presenting with symptoms of vertigo underwent both the SL test and the DL maneuver. Two groups-group A and group B-were randomly formed. Group A patients were assessed with first DL test, then SL test and group B patients were assessed with first SL then DH. The diagnostic accuracy of the SL test was assessed by determining its sensitivity and specificity in relation to the DH test, which served as the reference standard.</p><p><strong>Results: </strong>The SL test demonstrated 95.1% sensitivity and 96.97% specificity in detecting posterior canal BPPV, with comparable diagnostic accuracy to the DH test. Chi-square test (140.34) also emphasized the statistical significance of these results. The DH test's AUC of 0.902 shows a high capacity to differentiate between cases with and without BPPV. On the other hand, the SL test shows even greater performance in distinguishing between BPPV and non-BPPV cases, as seen by its higher AUC of 0.960.</p><p><strong>Conclusion: </strong>The SL test is a viable alternative to the DH test, offering similar sensitivity and specificity in diagnosing posterior canal BPPV. Its use may benefit patients with physical limitations.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"675-679"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Large-Scale Video Head Impulse Test Data: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.","authors":"Jessie N Patterson, Meredith E Adams, Manuel Vicente, Pamela J Schreiner, Kristen L Janky","doi":"10.1097/MAO.0000000000004510","DOIUrl":"10.1097/MAO.0000000000004510","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the quality and agreement of video head impulse test (vHIT) data collected by technicians without extensive vestibular training compared with audiologists.</p><p><strong>Study design: </strong>Review of data collected at a single time point (year 35) as part of a larger observational cohort study known as the Coronary Artery Risk Development in Young Adults (CARDIA) study.</p><p><strong>Setting: </strong>Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA.</p><p><strong>Participants: </strong>464 participants (928 ears) enrolled in the CARDIA Study, 5 novice technicians who completed vHIT, and 3 audiologists with extensive vHIT training.</p><p><strong>Intervention: </strong>Each technician completed a 2-hour, virtual vHIT training. Technicians recorded average head velocity, gain, presence/absence of saccades, and a data quality rating. Three audiologists with extensive vestibular experience re-reviewed all data for comparison. Data categorized as noisy and/or having saccades were reanalyzed to determine whether data cleaning improved interpretation.</p><p><strong>Main outcomes measures: </strong>vHIT gain, quality of vHIT results, presence of saccades.</p><p><strong>Results: </strong>A total of 823 ears (88.7%) were classified as normal, 10 ears (1.1%) were abnormal, 13 ears (1.4%) had low gain without saccades, and 82 ears (9%) had high gain (>1.2). The most frequent artifact was high gain. Data cleaning increased the percentage of saccades and changed the interpretation of eight participants (1.7%).</p><p><strong>Conclusions: </strong>Novice examiners can administer vHIT with online training and an initial practice period. Additional training on how to identify artifacts and clean data can improve population-based vHIT testing.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"686-692"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Cost-Effectiveness of Unilateral Cochlear Implants Versus Hearing Aids in Older Adults in Japan.","authors":"Norie Imagawa, Shuji Izumi, Takashi Shimazaki, Takashi Yamauchi, Shunya Ikeda, Shinichi Noto, Hiromi Kojima, Machi Suka","doi":"10.1097/MAO.0000000000004504","DOIUrl":"10.1097/MAO.0000000000004504","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the cost-effectiveness of cochlear implants in older adults with hearing impairment 65 years or older in Japan. In addition, this study aimed to establish a basis for making recommendations for cochlear implants in clinical practice for suitable patients.</p><p><strong>Design: </strong>We conducted a cost-utility analysis using the incremental cost-effectiveness ratio (ICER) to compare unilateral cochlear implants with hearing aids. The study involved participants 65 years or older with severe-to-profound hearing loss attending two cochlear implant surgery facilities in Japan. Costs were calculated from the participants' receipt data and standard clinical paths from medical care providers. Quality-adjusted life years (QALY) were assessed by patients using the Japanese version of the Health Utilities Index Mark 3 and by medical care providers using the visual analog scale (VAS). In addition, sensitivity analyses were performed by varying the utility value, discount rate, age at implantation, and costs to estimate the ICER under different scenarios.</p><p><strong>Results: </strong>Responses were received from 26 cochlear implant users and 8 hearing aid users. After applying the survival and discount rates to the utility values and costs, the ICER was $44,533, which falls within the acceptable willingness-to-pay threshold in Japan. Sensitivity analysis showed that the ICER was the most sensitive to the utility value, followed by the discount rate.</p><p><strong>Conclusions: </strong>The findings indicate that providing cochlear implants to older adults with hearing impairment is not only beneficial in terms of improved hearing performance but also economically efficient.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"634-640"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab.","authors":"Ethan M Kallenberger, Snimarjot Kaur, Brynn E Everist, Gregory A Ator, Selina A Gierer, Andrea F D'Mello","doi":"10.1097/MAO.0000000000004501","DOIUrl":"10.1097/MAO.0000000000004501","url":null,"abstract":"<p><strong>Objective: </strong>To highlight the efficacy of dupilumab in treating chronic otitis media with effusion (glue ear).</p><p><strong>Patients: </strong>Three patients with chronic otitis media with effusion (OME) refractory to medical and surgical treatment were retrospectively identified. All patients had medical history suggestive of the presence of eosinophilic inflammation.</p><p><strong>Interventions: </strong>Each patient received a 300-mg injection of dupilumab every 4 weeks for a total of three injections.</p><p><strong>Main outcome measures: </strong>Audiometric data, patient-reported incidence of new ear infections, patient-reported symptoms.</p><p><strong>Results: </strong>All patients reported subjective improvement in ear pain, drainage, and hearing loss between 2 weeks and 6 months on dupilumab therapy. In case 1 and case 2, audiograms showed some improvement in hearing loss posttreatment. Case 2 had an unexpected interruption of treatment for 4 weeks and reported return of thick ear drainage and difficulty with hearing.</p><p><strong>Conclusions: </strong>Dupilumab may be a novel, effective, and nonsurgical treatment option for patients with chronic otitis media with effusion and underlying atopic conditions.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e210-e214"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}