Otology & Neurotology最新文献

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A Systematic Review and Meta-Analysis of Post-Cochlear Implant Vestibular Dysfunction: Round Window Versus Standard Cochleostomy Approaches. 人工耳蜗植入后前庭功能障碍的系统回顾和荟萃分析:圆窗与标准耳蜗造口方法。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-03-24 DOI: 10.1097/MAO.0000000000004489
Abdullah F Alharbi, Hassan Alalawi, Abdulsalam Alqutub, Hisham B Alem, Afnan F Bukhari, Manal A Khoja, Faisal Zawawi
{"title":"A Systematic Review and Meta-Analysis of Post-Cochlear Implant Vestibular Dysfunction: Round Window Versus Standard Cochleostomy Approaches.","authors":"Abdullah F Alharbi, Hassan Alalawi, Abdulsalam Alqutub, Hisham B Alem, Afnan F Bukhari, Manal A Khoja, Faisal Zawawi","doi":"10.1097/MAO.0000000000004489","DOIUrl":"10.1097/MAO.0000000000004489","url":null,"abstract":"<p><strong>Background: </strong>Two main techniques for cochlear implantation (CI) are commonly used: the standard cochleostomy (SCA) and the round window approach (RWA). Initially, the RWA was more utilized, followed by the SCA for cases with challenging visualization. Recent studies show that RWA is preferred due to SCA's risk of damaging cochlear structures.</p><p><strong>Aim: </strong>We aim to compare post-CI complications between the RWA and SCA approaches.</p><p><strong>Methods: </strong>Five electronic databases were systematically searched to identify relevant studies. Eligibility screening was performed to determine inclusion criteria, and data extraction from the selected studies was conducted independently. Dichotomous outcomes were pooled as rate ratios (RR) and standard errors (SE), with significance determined by a p value >0.05 between CI subgroups. The generic inverse variance analysis method was applied with the employment of the random-effect model.</p><p><strong>Results: </strong>Our systematic review encompassed 82 studies, of which 58 were eligible for meta-analysis. Vertigo was documented in 10% of instances utilizing the RWA technique and in 8% of cases using the SCA method. Likewise, dizziness was noted in 18% of RWA cases and in 14% of SCA cases. The overall incidence of vestibular complications was 36% for RWA and 17% for SCA. However, statistical analysis revealed no significant differences between these approaches ( p < 0.05).</p><p><strong>Conclusion: </strong>Both the RWA and the SCA approaches demonstrate comparable post-CI complication profiles concerning dizziness, vertigo, and overall vestibular complications, with the RWA approach showing slightly higher incidences. However, no significant difference was found between the two techniques.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"505-514"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of a New Minimally Invasive Single-Drill Procedure for Installing Percutaneous Bone-Anchored Hearing Implants in Adult Patients. 一种新的微创单钻手术在成人患者中安装经皮骨锚定听力植入物的结果。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-02-24 DOI: 10.1097/MAO.0000000000004484
Miguel Angelo Hyppolito, Ana Cláudia Mirândola Barbosa Reis, Letícia Cândido de Oliveira, Karine Eying da Silva, Denny Marcos Garcia, Fabiana Danieli-Hyppolito
{"title":"Outcomes of a New Minimally Invasive Single-Drill Procedure for Installing Percutaneous Bone-Anchored Hearing Implants in Adult Patients.","authors":"Miguel Angelo Hyppolito, Ana Cláudia Mirândola Barbosa Reis, Letícia Cândido de Oliveira, Karine Eying da Silva, Denny Marcos Garcia, Fabiana Danieli-Hyppolito","doi":"10.1097/MAO.0000000000004484","DOIUrl":"10.1097/MAO.0000000000004484","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the surgical and audiological outcomes in adult bone-anchored hearing system (BAHS) users who underwent implantation using a minimally invasive, single-drill procedure (MONO procedure).</p><p><strong>Study design: </strong>Retrospective cohort design.</p><p><strong>Setting: </strong>University hospital.</p><p><strong>Patients: </strong>Adult subjects (≥18 yr), with conductive and mixed hearing loss, or single-sided deafness (SSD), who underwent BAHS surgery using MONO from 2021 to 2023.</p><p><strong>Intervention: </strong>BAHS implantation.</p><p><strong>Main outcome measures: </strong>Surgical and postoperative complications were investigated during the entire follow-up period. Preoperative unaided air- and bone-conduction thresholds, pure-tone average (PTA), air-bone gap (ABG), and monosyllabic word recognition scores (unaided- and softband-aided) were compared with the postoperative BAHS aided PTA, remaining ABG, functional gain, and monosyllabic word recognition scores.</p><p><strong>Results: </strong>Forty-four subjects aged between 20 and 70 (52 ± 15) years met the inclusion criteria. One subject (2.3%) required two punch incisions due to implant instability during surgery. Two subjects (4.6%) experienced adverse skin reactions. Pain (6.9%) and moisture (6.9%) at implant site were also reported. No other complications were reported over a mean follow-up time of 12.2 ± 5.7 months. The mean BAHS aided score was significantly greater than the mean unaided- and softband-aided scores. All subjects showed functional improvements after surgery (25-31 dB), and the average effective gain was 1.3 dB.</p><p><strong>Conclusion: </strong>The MONO procedure was shown to be a viable option for routine BAHS surgery in adults. The auditory performance of the subjects improved postoperatively, and complications were minimal and easily resolved. Further studies are required to investigate the long-term outcomes of MONO in this population.</p><p><strong>Level of evidence: </strong>4-Retrospective review.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"e190-e197"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Intratympanic Gentamicin on Cochlear Implant Outcomes. 鼓室内庆大霉素对人工耳蜗植入结果的影响。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1097/MAO.0000000000004451
Robert Böscke, Jan Hoffmeyer, Andreas Radeloff
{"title":"Impact of Intratympanic Gentamicin on Cochlear Implant Outcomes.","authors":"Robert Böscke, Jan Hoffmeyer, Andreas Radeloff","doi":"10.1097/MAO.0000000000004451","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004451","url":null,"abstract":"<p><strong>Introduction: </strong>Intratympanic gentamicin (ITG) instillation is a therapeutic option in advanced Menière's disease (MD) to control vertigo. ITG aims to induce vestibular hypofunction by selective ablation of vestibular hair cells. However, it may also adversely affect cochlear hair cells and the neural auditory pathway. Preservation of the neural auditory pathway is critical, as today cochlear implantation (CI) is the gold standard for auditory rehabilitation in patients with MD. This study assesses the impact of prior ITG treatment on CI outcomes in patients with MD.</p><p><strong>Methods: </strong>This retrospective cohort study included 36 CI recipients with MD. Patients were divided into two groups: ITG (n = 14) and Control (n = 22). Primary outcome measure was the CI-aided Freiburg monosyllabic words test at 65 dB SPL (WRS65[CI]) at follow-up visits T1 (0-3 months), T2 (3-6 months), and T3 (≥6 months).</p><p><strong>Results: </strong>Both groups showed significant improvements in aided WRS65 over time, with the ITG group exhibiting inferior outcomes compared to the control group (relative treatment effect [RTE] 0.38 [ITG] versus 0.57 [control]; p < 0.001). Post hoc analysis confirmed between-group differences in WRS65[CI] outcomes at all follow-up visits (T1: median 30% versus 46%, p = 0.012; T2: 40% versus 60%, p = 0.009; T3: 57.5% versus 72.5%, p = 0.027; ITG versus control group, respectively). A linear mixed-effects model demonstrated that ITG treatment was associated with lower WRS65[CI] outcomes (β = -18.85, p = 0.014), while other preimplantation hearing test results and age at implantation did not show significant effects on the outcome.</p><p><strong>Conclusion: </strong>ITG treatment was associated with worse CI outcomes in MD patients. We recommend that patients should be counseled regarding the potential adverse effects of ITG on the neural auditory pathway that may lead to inferior CI outcomes.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 5","pages":"494-498"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Stapedotomy: Ossicular Chain Bypass With the New Semisynthetic TORP. 新型镫骨切开术:新型半合成TORP听骨链旁路。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-04-11 DOI: 10.1097/MAO.0000000000004472
Giuseppe Malafronte
{"title":"A New Stapedotomy: Ossicular Chain Bypass With the New Semisynthetic TORP.","authors":"Giuseppe Malafronte","doi":"10.1097/MAO.0000000000004472","DOIUrl":"https://doi.org/10.1097/MAO.0000000000004472","url":null,"abstract":"<p><strong>Objectives: </strong>The study objective is to describe a new stapedotomy and its short-term hearing results.</p><p><strong>Study design: </strong>Prospective study.</p><p><strong>Setting: </strong>Tertiary referral center.</p><p><strong>Methods: </strong>From February to June 2024, was conducted a study on the first 13 total columellar ossiculoplasties with footplate fenestration performed in patients with otosclerosis. In all patients, we used the new semisynthetic TORP (NSSTORP). Its base was positioned on the footplate hole rim, and its head was positioned under the eardrum. The author named this new surgical technique \"tympano-stapedotomy.\" For all patients, the last audiometric control considered was performed on September 2024. The mean follow-up was of 5 months.</p><p><strong>Main outcome measures: </strong>Percentage of patients achieving an air-bone gap (ABG) of less or equal to 10 and 20 dB.</p><p><strong>Results: </strong>At the end of follow-up, the air-conduction pure-tone average (PTA) improved from a mean of 62.1 dB (SD = 18.9) preoperatively to a mean of 42.8 dB (SD = 13.1) postoperatively: an average of 19.3 dB gain. The mean preoperative ABG was 30.9 dB (SD = 9.2), and the mean postoperative ABG was 11.6 dB (SD = 6.4): an average of 19.2 dB gain. The postoperative ABG of ≤10 was achieved in 38.5% (n = 5), of ≤15 in 77% (n = 10), and of ≤20 in 100% (n = 13).</p><p><strong>Conclusion: </strong>The NSSTORP has a minimal technical challenge for building and placement. The tympano-stapedotomy bypasses the ossicular chain and most of the challenge maneuvers and complications associated with it. Its hearing results are good.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":"46 5","pages":"e152-e156"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Learning Curves in Virtual Reality Cortical Mastoidectomy Training Across Expertise Levels. 评估不同专业水平的虚拟现实皮质乳突切除术培训的学习曲线。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1097/MAO.0000000000004500
Jesslyn Clarance Lamtara, Sudanthi Wijewickrema, Jean-Marc Gerard, Stephen O'Leary
{"title":"Evaluating Learning Curves in Virtual Reality Cortical Mastoidectomy Training Across Expertise Levels.","authors":"Jesslyn Clarance Lamtara, Sudanthi Wijewickrema, Jean-Marc Gerard, Stephen O'Leary","doi":"10.1097/MAO.0000000000004500","DOIUrl":"10.1097/MAO.0000000000004500","url":null,"abstract":"<p><strong>Hypothesis: </strong>Virtual reality (VR) simulation has been established as an effective method of supplementing traditional surgical training. Learning curves can analyze skill acquisition over time in VR settings. Although previous studies explored learning curves of mastoidectomy performances on single specimen, this study analyzed learning curves on anatomically different virtual temporal bones across three expertise levels (novice, intermediate, and expert).</p><p><strong>Methods: </strong>Thirty participants were divided into three groups: 10 medical students (novice), 10 ear, nose and throat (ENT) registrars (intermediate), and 10 senior ear surgeons (expert). They performed mastoidectomy on eight anatomically different temporal bones on the University of Melbourne Temporal Bone Surgery Simulator. A blinded senior ENT surgeon assessed the final products of the dissections using the Melbourne Mastoidectomy Scale (MMS). Learning curves of MMS scores, number of strokes, average force, drilling time, and total time were compared between groups using Friedman tests. Within-group analyses were conducted with Wilcoxon signed-rank tests.</p><p><strong>Results: </strong>All performance metrics showed significant differences across all groups. Only comparison between intermediate and expert groups for average force was not significant. Within-group analyses showed significant differences in expert group for total and drilling time, intermediate group for average force, and novice group for total time. Individual learning curves of intermediate group demonstrated varied learning behavior.</p><p><strong>Conclusions: </strong>Trainee performance was not seen to reach the level of experts after eight repetitions on anatomically different specimens. Enhancing training with individualized feedback and increased repetitions may optimize skills acquisition.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"607-615"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Dual-Tasking on the Vestibulo-Ocular Reflex. 双重任务处理对前庭眼反射的影响。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1097/MAO.0000000000004470
Noa Rozendorn, Itay Avivi, Amit Wolfovitz, Yoav Gimmon
{"title":"The Impact of Dual-Tasking on the Vestibulo-Ocular Reflex.","authors":"Noa Rozendorn, Itay Avivi, Amit Wolfovitz, Yoav Gimmon","doi":"10.1097/MAO.0000000000004470","DOIUrl":"10.1097/MAO.0000000000004470","url":null,"abstract":"<p><strong>Objective: </strong>Daily activities often involve performing multiple tasks simultaneously and require stable gait and posture. The vestibular system provides balance control through its reflexes mediated via the vestibulospinal tract and gaze stability mediated via the vestibulo-ocular reflex (VOR), which maintains stable vision during head motion while continuously adapting to environmental changes. Cognitive and motor activities reportedly can adversely affect balance function and vice versa. We hereby investigate how dual cognitive and motor tasks influence the VOR and its adaptability to varying target distances by means of the video head impulse test (vHIT).</p><p><strong>Study design: </strong>Prospective interventional study.</p><p><strong>Setting: </strong>Tertiary academic medical center.</p><p><strong>Patients: </strong>Adults aged 18 to 40 without a history of instability disorders, otologic surgeries, or prior strokes.</p><p><strong>Intervention: </strong>vHIT testing.</p><p><strong>Main outcome measure: </strong>Sixteen participants underwent 14 vHITs under single-task and dual-task (cognitive or motor) conditions with far (1.5 m) and near (15 cm) target distances. Two types of activities were chosen for both the cognitive and motor tasks. The VOR gain and its adaptation, measured as the ratio of near-to-far gain, were assessed. A paired t-test was used to evaluate differences in reflex gain and adaptation between single- and dual-task conditions.</p><p><strong>Results: </strong>There were no significant differences in VOR gain or adaptation between single-task and either cognitive or motor dual-task conditions. Similar reflex gains were observed between dual-task conditions for both far and near targets.</p><p><strong>Conclusions: </strong>Gaze stability mediated by the VOR is a robust function with low sensitivity to external loads, unlike gait and posture balance control.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"567-572"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and Effectiveness of the Titanium mAXIS Stapes Prosthesis: Multicentric Short-Term Outcome. 钛mAXIS镫骨假体的安全性和有效性:多中心短期疗效。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.1097/MAO.0000000000004462
Dirk Beutner, Nicholas Bevis, Benjamin Loader, Franz Windisch, Susan Arndt, Christian Offergeld, Wendelin Wolfram, Lisa Niederwanger, Paul Martin Zwittag, Nina Rubicz, Esther Schimanski, Christoph Arnoldner, Dominik Riss, Piotr H Skarżyński, Łukasz Plichta, Joachim Hornung, Lava Taha, Thomas Lenarz, Susan Busch, Astrid Magele, Georg Sprinzl
{"title":"Safety and Effectiveness of the Titanium mAXIS Stapes Prosthesis: Multicentric Short-Term Outcome.","authors":"Dirk Beutner, Nicholas Bevis, Benjamin Loader, Franz Windisch, Susan Arndt, Christian Offergeld, Wendelin Wolfram, Lisa Niederwanger, Paul Martin Zwittag, Nina Rubicz, Esther Schimanski, Christoph Arnoldner, Dominik Riss, Piotr H Skarżyński, Łukasz Plichta, Joachim Hornung, Lava Taha, Thomas Lenarz, Susan Busch, Astrid Magele, Georg Sprinzl","doi":"10.1097/MAO.0000000000004462","DOIUrl":"10.1097/MAO.0000000000004462","url":null,"abstract":"<p><strong>Objective: </strong>Otosclerosis leads to ossification of the stapes footplate and is responsible for a significant number of patients having hearing loss. Stapes surgery is a treatment for otosclerosis with excellent postoperative hearing outcomes. The aim of this retrospective study was to analyze the safety and effectiveness of the titanium mAXIS prosthesis in a multicentric setting.</p><p><strong>Methods: </strong>Ninety-four surgeries with implantation of the mAXIS stapes prosthesis took place in a multicenter study group. During follow-up at 59 (±48.1) days, pure-tone audiometry was performed. The pure-tone averages of 0.5, 1, 2, and 3 kHz (PTA-4) were determined.</p><p><strong>Results: </strong>No device-related adverse events were reported. There were 88 patients who reported for follow-up, at which pure-tone audiometry was performed. The PTA-4 air-bone gap (ABG) at follow-up was 8.8 (±6.0) dB. In 64.8% of the patients, the postoperative PTA-4 ABG was within 10 dB and in 94.3% it was within 20 dB. The postoperative PTA-4 thresholds for bone conduction were stable in 95.5% of cases.</p><p><strong>Conclusion: </strong>The results of this multicentric study demonstrate the safety of the mAXIS titanium stapes prosthesis. The prosthesis shows promising audiological outcomes. Future studies are needed to assess long-term efficacy.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"561-566"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LETTER TO THE EDITOR CONCERNING: "HEARING DEVICE COIL PLACEMENT LATERAL TO THE TEMPORALIS: AN ALTERNATIVE TO FLAP THINNING FOR COCHLEAR AND TRANSCUTANEOUS BONE-ANCHORED IMPLANTS". 致编辑的信涉及:“颞肌外侧放置助听器线圈:耳蜗和经皮骨锚定植入物皮瓣变薄的另一种选择”。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-02-19 DOI: 10.1097/MAO.0000000000004477
Orhan Ozturan, Alper Yenigun, Ramazan Bahadir Kucuk, Erol Senturk, Sabri Baki Eren, Fadlullah Aksoy
{"title":"LETTER TO THE EDITOR CONCERNING: \"HEARING DEVICE COIL PLACEMENT LATERAL TO THE TEMPORALIS: AN ALTERNATIVE TO FLAP THINNING FOR COCHLEAR AND TRANSCUTANEOUS BONE-ANCHORED IMPLANTS\".","authors":"Orhan Ozturan, Alper Yenigun, Ramazan Bahadir Kucuk, Erol Senturk, Sabri Baki Eren, Fadlullah Aksoy","doi":"10.1097/MAO.0000000000004477","DOIUrl":"10.1097/MAO.0000000000004477","url":null,"abstract":"","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"605"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noninvasive Targeted Temperature Management of the Inner Ear: Numerical Simulations and Experimental Measurements in a Human Cadaver Model. 内耳无创目标温度管理:人体尸体模型的数值模拟和实验测量。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-02-24 DOI: 10.1097/MAO.0000000000004476
Maria Fernanda Yepes, Michael E Hoffer, Juan Armando Chiossone, Nathaniel Soejima, Curtis S King, Suhrud M Rajguru
{"title":"Noninvasive Targeted Temperature Management of the Inner Ear: Numerical Simulations and Experimental Measurements in a Human Cadaver Model.","authors":"Maria Fernanda Yepes, Michael E Hoffer, Juan Armando Chiossone, Nathaniel Soejima, Curtis S King, Suhrud M Rajguru","doi":"10.1097/MAO.0000000000004476","DOIUrl":"10.1097/MAO.0000000000004476","url":null,"abstract":"<p><strong>Hypothesis: </strong>Mild therapeutic hypothermia (MTH) could be delivered to the human inner ear using a localized, noninvasive approach to achieve protective temperature reductions without systemic side effects.</p><p><strong>Background: </strong>MTH has demonstrated protective effects in the cochlea following injuries such as device implantation, ototoxicity, and noise overexposure. It targets key cellular mechanisms, including proinflammatory pathways, oxidative stress, pyroptosis, and apoptosis. However, systemic and invasive methods for MTH carry risks and are less practical for broader clinical applications. Developing a localized, noninvasive approach could offer a safer, more accessible solution for hearing preservation after cochlear injury.</p><p><strong>Methods: </strong>Cadaveric middle and inner ear structures, maintained near physiological conditions, were used to test a custom-designed cooling gel pack (ReBound) placed externally on the temporal bone. Temperature changes were recorded over 60 or 30 minutes. To complement experimental findings, three-dimensional geometrical models were created from imaging data, and finite element heat transfer analysis simulated temperature changes across inner ear structures.</p><p><strong>Results: </strong>With external gel pack application, inner ear temperatures dropped by 2.9°C within 30 minutes and 4.6°C within 60 minutes. Cooling persisted for 10 minutes post-device removal. Numerical modeling corroborated these findings, indicating average temperature reductions of 2°C to 4°C. Biological sex differences were observed in cooling efficiency and overall temperature drop.</p><p><strong>Conclusion: </strong>This study demonstrates that localized, noninvasive MTH can effectively reduce inner ear temperatures to therapeutically relevant levels. These findings support a promising, clinically translatable approach for protecting cochlear structure and function after injury, with minimal systemic risks.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"598-604"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Coherence Tomography as a Tool for Quantitative Imaging of the Tympanic Membrane and Middle Ear. 光学相干层析成像作为鼓膜和中耳定量成像的工具。
IF 1.9 3区 医学
Otology & Neurotology Pub Date : 2025-06-01 Epub Date: 2025-02-25 DOI: 10.1097/MAO.0000000000004441
Ryan Long, Wihan Kim, Marcela Morán, Frank D Macías-Escrivá, Patricia M Quiñones, John S Oghalai, Brian E Applegate
{"title":"Optical Coherence Tomography as a Tool for Quantitative Imaging of the Tympanic Membrane and Middle Ear.","authors":"Ryan Long, Wihan Kim, Marcela Morán, Frank D Macías-Escrivá, Patricia M Quiñones, John S Oghalai, Brian E Applegate","doi":"10.1097/MAO.0000000000004441","DOIUrl":"10.1097/MAO.0000000000004441","url":null,"abstract":"<p><strong>Objective: </strong>Advances in optical coherence tomography have improved diagnostic imaging for otologic pathologies. We investigated handheld OCT (HHOCT) otoscopic device's ability to quantitatively analyze the middle ear and provide valuable information for the management of middle ear pathologies.</p><p><strong>Study design: </strong>Cross-sectional cohort.</p><p><strong>Methods: </strong>Eleven healthy patients, 5 patients with unilateral pathology, 6 patients with retraction pockets, and 1 patient undergoing ossiculoplasty were imaged using HHOCT in the clinic. Middle ear distances and retraction pocket depth were calculated using OCT volumes and compared to those on CT and in literature. Partial ossicular replacement prosthesis length was calculated before surgery and compared to the length chosen by an expert otologist. Data were characterized using descriptive statistics and paired t -tests. Volumes were analyzed and postprocessed using Amira (Thermofisher Scientific, Waltham, MA) and Fiji (NIH).</p><p><strong>Results: </strong>HHOCT could image and obtain quantitative measurements of the middle ear at the point of care with greater resolution and precision than traditional imaging modalities. Mean incus diameter on OCT was 0.728 ± 0.089 mm, in agreement with cadaver studies. Measured middle ear distances and retraction pocket depths were not statistically significantly different from those measured on CT. The predicted prosthesis size for the ossiculoplasty patient was 2.46 mm, closely matching the 2-mm length chosen by an expert otologist.</p><p><strong>Conclusion: </strong>OCT can provide reliable measurements of the tympanic membrane and middle ear structures not readily available through traditional imaging modalities. Pre- or intrasurgical measurements with OCT may be beneficial for guidance on size and placement of ossicular prosthetics and may improve hearing outcomes.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":"525-531"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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